Mus musculus

11 known processes

Klk1b22

kallikrein 1-related peptidase b22

(Aliases: MGC118112,Egfbp-1,Klk22,mGk-22,Egfbp1)

Klk1b22 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
inflammatory response GO:0006954 244 0.088
Mouse
positive regulation of vasoconstriction GO:0045907 4 0.086
Rat
regulation of transferase activity GO:0051338 263 0.079
Mouse
striated muscle tissue development GO:0014706 293 0.075
Mouse
cellular amino acid metabolic process GO:0006520 103 0.075
oxidation reduction process GO:0055114 342 0.074
regulation of kinase activity GO:0043549 249 0.064
Mouse
cellular lipid metabolic process GO:0044255 323 0.062
Mouse
amine metabolic process GO:0009308 45 0.059
protein maturation GO:0051604 176 0.059
positive regulation of kinase activity GO:0033674 155 0.056
Mouse
fertilization GO:0009566 127 0.055
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.053
action potential GO:0001508 78 0.053
small gtpase mediated signal transduction GO:0007264 97 0.052
Mouse
muscle system process GO:0003012 141 0.051
Mouse
regulation of response to wounding GO:1903034 189 0.050
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.050
protein activation cascade GO:0072376 19 0.049
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.049
response to organic cyclic compound GO:0014070 198 0.048
protein processing GO:0016485 163 0.048
regulation of cellular ketone metabolic process GO:0010565 66 0.048
cellular amine metabolic process GO:0044106 44 0.048
epithelial cell proliferation GO:0050673 174 0.047
Mouse
male gamete generation GO:0048232 285 0.044
regulation of cytokine production GO:0001817 266 0.044
macromolecule catabolic process GO:0009057 281 0.043
Mouse
protein catabolic process GO:0030163 221 0.043
Mouse
cellular ketone metabolic process GO:0042180 84 0.042
heart contraction GO:0060047 93 0.042
Mouse
cytokine production GO:0001816 319 0.042
regulation of neuron projection development GO:0010975 169 0.042
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.041
regulation of cell projection organization GO:0031344 206 0.041
Mouse
negative regulation of neuron projection regeneration GO:0070571 3 0.040
Mouse
positive regulation of transferase activity GO:0051347 167 0.039
Mouse
extracellular structure organization GO:0043062 148 0.037
Mouse
regulation of lipid metabolic process GO:0019216 118 0.037
Mouse
negative regulation of cell development GO:0010721 169 0.036
Mouse
blood vessel morphogenesis GO:0048514 285 0.033
cell adhesion GO:0007155 329 0.033
cognition GO:0050890 149 0.033
Mouse
spermatogenesis GO:0007283 284 0.033
synapse organization GO:0050808 125 0.032
Mouse
response to organonitrogen compound GO:0010243 246 0.032
learning or memory GO:0007611 148 0.032
Mouse
binding of sperm to zona pellucida GO:0007339 34 0.031
Mouse
cation transport GO:0006812 399 0.031
striated muscle contraction GO:0006941 45 0.031
Mouse
lipid biosynthetic process GO:0008610 179 0.031
cellular chemical homeostasis GO:0055082 215 0.031
maintenance of location GO:0051235 89 0.030
regulation of anatomical structure size GO:0090066 178 0.030
Mouse Rat
cardiac muscle contraction GO:0060048 32 0.030
Mouse
neuronal action potential GO:0019228 54 0.030
regulation of cellular amino acid metabolic process GO:0006521 5 0.030
regulation of neuron differentiation GO:0045664 281 0.030
Mouse
muscle tissue development GO:0060537 308 0.029
Mouse
ion transmembrane transport GO:0034220 361 0.029
multicellular organismal signaling GO:0035637 91 0.029
cell type specific apoptotic process GO:0097285 268 0.028
purine ribonucleotide metabolic process GO:0009150 290 0.028
transmembrane transport GO:0055085 412 0.028
organonitrogen compound biosynthetic process GO:1901566 192 0.028
Mouse
regulation of blood pressure GO:0008217 93 0.028
Mouse
cellular homeostasis GO:0019725 240 0.027
regulation of system process GO:0044057 200 0.026
Mouse Rat
positive regulation of lipid metabolic process GO:0045834 40 0.026
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.026
regulation of systemic arterial blood pressure GO:0003073 61 0.026
Mouse
regulation of cellular response to stress GO:0080135 159 0.026
Mouse
regulation of membrane potential GO:0042391 192 0.026
peptidyl amino acid modification GO:0018193 336 0.026
cell cell recognition GO:0009988 44 0.025
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.025
synaptic transmission GO:0007268 329 0.025
Mouse
blood circulation GO:0008015 195 0.025
Mouse Rat
negative regulation of molecular function GO:0044092 258 0.025
gland development GO:0048732 330 0.025
regulation of cell activation GO:0050865 289 0.025
mapk cascade GO:0000165 281 0.024
transmission of nerve impulse GO:0019226 76 0.024
vasodilation GO:0042311 28 0.024
Mouse
regulation of homeostatic process GO:0032844 182 0.024
negative regulation of response to wounding GO:1903035 77 0.024
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.024
germ cell development GO:0007281 185 0.024
nucleobase containing small molecule metabolic process GO:0055086 352 0.024
negative regulation of cellular component organization GO:0051129 194 0.024
Mouse
muscle contraction GO:0006936 101 0.023
Mouse
positive regulation of lipid kinase activity GO:0090218 11 0.023
Mouse
purine containing compound metabolic process GO:0072521 311 0.023
positive regulation of cytokine production GO:0001819 174 0.023
cation homeostasis GO:0055080 212 0.022
organic cyclic compound catabolic process GO:1901361 295 0.022
positive regulation of cell death GO:0010942 224 0.022
monocarboxylic acid metabolic process GO:0032787 191 0.022
t cell activation GO:0042110 289 0.022
regulation of protein localization GO:0032880 231 0.022
cellular response to lipid GO:0071396 145 0.022
calcium ion homeostasis GO:0055074 127 0.021
nucleoside phosphate metabolic process GO:0006753 338 0.021
immune effector process GO:0002252 321 0.021
positive regulation of protein modification process GO:0031401 299 0.021
zymogen activation GO:0031638 41 0.021
heart morphogenesis GO:0003007 178 0.021
Mouse
regulation of defense response GO:0031347 233 0.021
circulatory system process GO:0003013 197 0.020
Mouse Rat
regulation of organelle organization GO:0033043 289 0.020
peptide metabolic process GO:0006518 46 0.020
Mouse
response to peptide GO:1901652 136 0.020
positive regulation of secretion GO:0051047 130 0.020
spermatid development GO:0007286 108 0.020
aromatic compound catabolic process GO:0019439 286 0.020
single fertilization GO:0007338 82 0.020
Mouse
positive regulation of programmed cell death GO:0043068 218 0.020
cellular amide metabolic process GO:0043603 58 0.020
Mouse
fatty acid metabolic process GO:0006631 121 0.020
reactive nitrogen species metabolic process GO:2001057 0 0.020
glycoprotein metabolic process GO:0009100 116 0.020
sulfur compound metabolic process GO:0006790 100 0.020
cardiac muscle tissue development GO:0048738 130 0.020
Mouse
innate immune response GO:0045087 157 0.020
memory GO:0007613 58 0.020
Mouse
positive regulation of apoptotic process GO:0043065 217 0.020
regulation of blood vessel size GO:0050880 56 0.020
Mouse Rat
response to molecule of bacterial origin GO:0002237 143 0.019
response to inorganic substance GO:0010035 96 0.019
cellular ion homeostasis GO:0006873 165 0.019
metal ion homeostasis GO:0055065 189 0.019
kinin cascade GO:0002254 2 0.019
Mouse
reactive oxygen species metabolic process GO:0072593 84 0.019
fat cell differentiation GO:0045444 160 0.019
microtubule based process GO:0007017 236 0.019
homeostasis of number of cells GO:0048872 210 0.019
skeletal muscle organ development GO:0060538 163 0.018
positive regulation of protein kinase activity GO:0045860 144 0.018
regulation of secretion GO:0051046 274 0.018
hematopoietic progenitor cell differentiation GO:0002244 143 0.018
negative regulation of cellular protein metabolic process GO:0032269 247 0.018
negative regulation of immune system process GO:0002683 209 0.018
regulation of mapk cascade GO:0043408 248 0.018
negative regulation of cellular amine metabolic process GO:0033239 1 0.018
regulation of lymphocyte activation GO:0051249 240 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
reactive oxygen species biosynthetic process GO:1903409 8 0.018
carbohydrate derivative biosynthetic process GO:1901137 183 0.018
cellular metal ion homeostasis GO:0006875 151 0.018
myeloid cell differentiation GO:0030099 233 0.018
sequestering of metal ion GO:0051238 19 0.018
cellular response to biotic stimulus GO:0071216 92 0.018
negative regulation of phosphorus metabolic process GO:0010563 184 0.018
regulation of feeding behavior GO:0060259 3 0.018
heart process GO:0003015 94 0.018
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.017
chromatin disassembly GO:0031498 1 0.017
sperm egg recognition GO:0035036 37 0.017
Mouse
apoptotic signaling pathway GO:0097190 306 0.017
lymphocyte proliferation GO:0046651 164 0.017
response to insulin GO:0032868 100 0.017
regulation of secretion by cell GO:1903530 249 0.017
glycosyl compound metabolic process GO:1901657 246 0.017
cofactor metabolic process GO:0051186 80 0.017
rhythmic process GO:0048511 174 0.017
spermatid differentiation GO:0048515 115 0.017
carbohydrate biosynthetic process GO:0016051 74 0.017
cardiac chamber development GO:0003205 108 0.017
Mouse
ribose phosphate metabolic process GO:0019693 291 0.017
muscle cell differentiation GO:0042692 261 0.017
leukocyte differentiation GO:0002521 342 0.017
activation of immune response GO:0002253 138 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.017
cellular response to organic cyclic compound GO:0071407 87 0.017
response to acid chemical GO:0001101 111 0.017
protein secretion GO:0009306 111 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.017
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
myosin filament organization GO:0031033 3 0.016
chromatin organization GO:0006325 206 0.016
extracellular matrix organization GO:0030198 147 0.016
Mouse
regulation of cell cycle process GO:0010564 160 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
negative regulation of nervous system development GO:0051961 156 0.016
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 40 0.016
nucleotide metabolic process GO:0009117 332 0.016
regulation of hormone levels GO:0010817 211 0.016
dephosphorylation GO:0016311 129 0.016
defense response to other organism GO:0098542 197 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
locomotory behavior GO:0007626 195 0.016
small molecule biosynthetic process GO:0044283 132 0.016
sensory perception GO:0007600 245 0.016
cardiac chamber morphogenesis GO:0003206 93 0.016
Mouse
regulation of protein processing GO:0070613 96 0.016
regulation of cell cycle GO:0051726 281 0.016
regeneration GO:0031099 38 0.016
Mouse
single organism cell adhesion GO:0098602 156 0.015
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.015
Mouse
regulation of tube size GO:0035150 57 0.015
Mouse Rat
cellular response to lipopolysaccharide GO:0071222 77 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
response to extracellular stimulus GO:0009991 127 0.015
negative regulation of protein modification process GO:0031400 163 0.015
cellular nitrogen compound catabolic process GO:0044270 280 0.015
vascular process in circulatory system GO:0003018 62 0.015
Mouse Rat
protein glycosylation GO:0006486 55 0.015
regulation of protein maturation GO:1903317 96 0.015
response to radiation GO:0009314 165 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
ras protein signal transduction GO:0007265 77 0.015
glycoprotein biosynthetic process GO:0009101 89 0.015
sequestering of calcium ion GO:0051208 18 0.015
regulation of phosphatidylinositol 3 kinase activity GO:0043551 14 0.015
Mouse
cellular response to molecule of bacterial origin GO:0071219 83 0.015
forebrain development GO:0030900 302 0.015
nucleoside metabolic process GO:0009116 246 0.015
g protein coupled receptor signaling pathway GO:0007186 243 0.015
cellular response to dna damage stimulus GO:0006974 207 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
purine ribonucleoside metabolic process GO:0046128 241 0.015
wnt signaling pathway GO:0016055 188 0.015
phospholipid metabolic process GO:0006644 87 0.015
Mouse
regulation of establishment of protein localization GO:0070201 181 0.015
response to lipopolysaccharide GO:0032496 128 0.015
dna metabolic process GO:0006259 303 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
response to testosterone GO:0033574 3 0.014
regulation of leukocyte differentiation GO:1902105 159 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
ossification GO:0001503 216 0.014
heterocycle catabolic process GO:0046700 280 0.014
organonitrogen compound catabolic process GO:1901565 264 0.014
positive regulation of cell projection organization GO:0031346 95 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
regulation of proteolysis GO:0030162 164 0.014
epithelial tube morphogenesis GO:0060562 303 0.014
multicellular organism growth GO:0035264 161 0.014
peptidyl tyrosine phosphorylation GO:0018108 143 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
regulation of cell adhesion GO:0030155 154 0.014
regulation of hydrolase activity GO:0051336 246 0.014
placenta development GO:0001890 140 0.014
negative regulation of protein phosphorylation GO:0001933 126 0.014
ribonucleoside triphosphate metabolic process GO:0009199 220 0.014
cytokine mediated signaling pathway GO:0019221 115 0.014
carbohydrate metabolic process GO:0005975 230 0.014
regulation of lymphocyte mediated immunity GO:0002706 84 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
regulation of inflammatory response GO:0050727 147 0.014
nucleoside phosphate catabolic process GO:1901292 222 0.014
cellular carbohydrate metabolic process GO:0044262 119 0.014
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.014
single organismal cell cell adhesion GO:0016337 131 0.014
divalent inorganic cation homeostasis GO:0072507 138 0.013
response to oxidative stress GO:0006979 123 0.013
cytoplasmic transport GO:0016482 234 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
camera type eye development GO:0043010 266 0.013
cellular calcium ion homeostasis GO:0006874 119 0.013
response to growth factor GO:0070848 198 0.013
acute inflammatory response GO:0002526 41 0.013
Mouse
regulation of ion transmembrane transport GO:0034765 119 0.013
mitochondrion organization GO:0007005 134 0.013
glycosylation GO:0070085 62 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
respiratory system development GO:0060541 190 0.013
regulation of protein transport GO:0051223 163 0.013
regulation of t cell activation GO:0050863 170 0.013
response to peptide hormone GO:0043434 127 0.013
sensory organ morphogenesis GO:0090596 242 0.013
compound eye development GO:0048749 1 0.013
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.013
immune response regulating signaling pathway GO:0002764 125 0.013
steroid biosynthetic process GO:0006694 47 0.013
cellular response to peptide GO:1901653 92 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
regulation of ion transport GO:0043269 215 0.013
cellular response to peptide hormone stimulus GO:0071375 92 0.013
purine nucleoside triphosphate catabolic process GO:0009146 203 0.013
macromolecule glycosylation GO:0043413 55 0.013
nucleoside catabolic process GO:0009164 206 0.013
organelle localization GO:0051640 179 0.013
regulation of systemic arterial blood pressure by hormone GO:0001990 25 0.013
Mouse
response to light stimulus GO:0009416 135 0.013
regulation of fat cell differentiation GO:0045598 81 0.013
nucleotide catabolic process GO:0009166 217 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.012
left ventricular cardiac muscle tissue morphogenesis GO:0003220 2 0.012
Mouse
lipid localization GO:0010876 126 0.012
secondary alcohol metabolic process GO:1902652 3 0.012
digestive tract development GO:0048565 190 0.012
ensheathment of neurons GO:0007272 76 0.012
Mouse
t cell proliferation GO:0042098 120 0.012
vasoconstriction GO:0042310 27 0.012
Rat
endocytosis GO:0006897 168 0.012
nucleoside triphosphate catabolic process GO:0009143 205 0.012
cation transmembrane transport GO:0098655 266 0.012
nitrogen compound transport GO:0071705 271 0.012
anion transport GO:0006820 177 0.012
negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 4 0.012
morphogenesis of a branching structure GO:0001763 203 0.012
cellular alcohol metabolic process GO:0044107 3 0.012
defense response to bacterium GO:0042742 119 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
sperm motility GO:0030317 47 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
embryonic organ morphogenesis GO:0048562 276 0.012
male sex differentiation GO:0046661 109 0.012
cellular response to cadmium ion GO:0071276 3 0.012
negative regulation of neuron projection development GO:0010977 50 0.012
Mouse
protein localization to organelle GO:0033365 185 0.012
response to nutrient levels GO:0031667 109 0.012
organic anion transport GO:0015711 137 0.012
membrane organization GO:0061024 245 0.012
neurological system process involved in regulation of systemic arterial blood pressure GO:0001976 18 0.012
Mouse
chromatin modification GO:0016568 187 0.012
peptidyl tyrosine modification GO:0018212 145 0.012
regulation of neurological system process GO:0031644 22 0.012
Mouse
negative regulation of protein maturation GO:1903318 79 0.012
membrane lipid metabolic process GO:0006643 53 0.012
regulation of systemic arterial blood pressure by renin angiotensin GO:0003081 20 0.012
Mouse
angiogenesis GO:0001525 201 0.012
leukocyte proliferation GO:0070661 172 0.012
regulation of protein kinase activity GO:0045859 232 0.011
organic hydroxy compound metabolic process GO:1901615 203 0.011
generation of precursor metabolites and energy GO:0006091 103 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
ear development GO:0043583 200 0.011
carbohydrate homeostasis GO:0033500 128 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.011
regulation of leukocyte proliferation GO:0070663 121 0.011
positive regulation of mapk cascade GO:0043410 170 0.011
icosanoid metabolic process GO:0006690 33 0.011
steroid metabolic process GO:0008202 119 0.011
cytosolic calcium ion homeostasis GO:0051480 70 0.011
regulation of map kinase activity GO:0043405 120 0.011
purine nucleotide catabolic process GO:0006195 211 0.011
regulation of myelination GO:0031641 20 0.011
Mouse
leukocyte mediated immunity GO:0002443 174 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
methylation GO:0032259 134 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.011
response to amino acid GO:0043200 37 0.011
ameboidal type cell migration GO:0001667 128 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
regulation of blood circulation GO:1903522 93 0.011
Rat
positive regulation of hydrolase activity GO:0051345 148 0.011
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.011
alpha amino acid metabolic process GO:1901605 59 0.011
cellular response to acid chemical GO:0071229 68 0.011
energy derivation by oxidation of organic compounds GO:0015980 77 0.011
olfactory learning GO:0008355 2 0.011
organelle fission GO:0048285 170 0.011
positive regulation of leukocyte differentiation GO:1902107 86 0.011
developmental maturation GO:0021700 193 0.011
hexose metabolic process GO:0019318 98 0.011
digestive system development GO:0055123 200 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
mitotic cell cycle process GO:1903047 159 0.011
positive regulation of defense response GO:0031349 124 0.011
regulation of action potential GO:0098900 4 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
positive regulation of blood circulation GO:1903524 22 0.011
Rat
cellular response to insulin stimulus GO:0032869 78 0.011
positive regulation of protein transport GO:0051222 93 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
regulation of lymphocyte proliferation GO:0050670 117 0.011
glucose homeostasis GO:0042593 128 0.011
negative regulation of neuron differentiation GO:0045665 101 0.011
Mouse
cellular response to amino acid stimulus GO:0071230 29 0.011
dna repair GO:0006281 107 0.011
negative regulation of proteolysis GO:0045861 74 0.010
covalent chromatin modification GO:0016569 163 0.010
nucleoside monophosphate metabolic process GO:0009123 85 0.010
rho protein signal transduction GO:0007266 32 0.010
regulation of angiogenesis GO:0045765 81 0.010
protein ubiquitination GO:0016567 171 0.010
ribonucleoside monophosphate metabolic process GO:0009161 80 0.010
purine containing compound catabolic process GO:0072523 213 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
glycosyl compound catabolic process GO:1901658 206 0.010
hormone metabolic process GO:0042445 86 0.010
branching morphogenesis of an epithelial tube GO:0048754 159 0.010
cytokinetic process GO:0032506 2 0.010
axonogenesis GO:0007409 274 0.010
inorganic ion transmembrane transport GO:0098660 234 0.010
striated muscle myosin thick filament assembly GO:0071688 1 0.010
positive regulation of neuron differentiation GO:0045666 141 0.010
organelle assembly GO:0070925 177 0.010
myosin filament assembly GO:0031034 2 0.010
neuron death GO:0070997 154 0.010
skin development GO:0043588 220 0.010
purine nucleotide metabolic process GO:0006163 302 0.010
adaptive immune response GO:0002250 155 0.010
organic acid biosynthetic process GO:0016053 86 0.010
response to drug GO:0042493 75 0.010
regulation of lipid biosynthetic process GO:0046890 54 0.010

Klk1b22 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.022
disease of anatomical entity DOID:7 0 0.021
nervous system disease DOID:863 0 0.021
inherited metabolic disorder DOID:655 0 0.015
central nervous system disease DOID:331 0 0.014
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
musculoskeletal system disease DOID:17 0 0.012
neurodegenerative disease DOID:1289 0 0.011
organ system cancer DOID:0050686 0 0.011