Mus musculus

167 known processes

Irf8

interferon regulatory factor 8

(Aliases: Icsbp1,IRF-8,ICSBP,AI893568,Myls)

Irf8 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
adaptive immune response GO:0002250 155 0.938
Mouse
immune response activating signal transduction GO:0002757 116 0.926
Mouse
lymphocyte differentiation GO:0030098 242 0.926
Mouse
regulation of myd88 independent toll like receptor signaling pathway GO:0034127 1 0.789
Mouse
lymphocyte mediated immunity GO:0002449 139 0.781
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.737
Mouse
t cell activation GO:0042110 289 0.736
Mouse
leukocyte proliferation GO:0070661 172 0.729
Mouse
b cell activation GO:0042113 161 0.710
lymphocyte proliferation GO:0046651 164 0.642
Mouse
negative regulation of phosphorus metabolic process GO:0010563 184 0.621
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.621
Mouse
cd8 positive alpha beta t cell proliferation GO:0035740 1 0.617
Mouse
t cell differentiation GO:0030217 174 0.603
Mouse
activation of immune response GO:0002253 138 0.588
Mouse
regulation of leukocyte proliferation GO:0070663 121 0.564
Mouse
alpha beta t cell differentiation GO:0046632 69 0.562
Mouse
leukocyte mediated immunity GO:0002443 174 0.560
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.557
regulation of t cell differentiation GO:0045580 83 0.555
Mouse
response to interferon gamma GO:0034341 34 0.548
Mouse
leukocyte differentiation GO:0002521 342 0.524
Mouse
negative regulation of leukocyte differentiation GO:1902106 51 0.519
Mouse
negative regulation of immune system process GO:0002683 209 0.513
Mouse
t cell proliferation GO:0042098 120 0.510
Mouse
positive regulation of lymphocyte activation GO:0051251 140 0.503
regulation of b cell activation GO:0050864 81 0.502
amine metabolic process GO:0009308 45 0.499
cellular response to interferon gamma GO:0071346 25 0.487
Mouse
actin cytoskeleton organization GO:0030036 220 0.484
regulation of cell activation GO:0050865 289 0.456
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.455
negative regulation of protein modification process GO:0031400 163 0.446
alpha beta t cell activation GO:0046631 91 0.440
Mouse
regulation of b cell differentiation GO:0045577 23 0.404
immune response regulating signaling pathway GO:0002764 125 0.396
Mouse
gland development GO:0048732 330 0.393
Mouse
metal ion homeostasis GO:0055065 189 0.385
positive regulation of lymphocyte differentiation GO:0045621 61 0.381
antigen receptor mediated signaling pathway GO:0050851 64 0.378
b cell differentiation GO:0030183 78 0.377
cation transport GO:0006812 399 0.373
homeostasis of number of cells GO:0048872 210 0.365
cellular ketone metabolic process GO:0042180 84 0.357
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.353
positive regulation of leukocyte proliferation GO:0070665 73 0.337
leukocyte activation involved in immune response GO:0002366 126 0.334
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.323
regulation of lymphocyte proliferation GO:0050670 117 0.320
Mouse
covalent chromatin modification GO:0016569 163 0.316
Mouse
immune effector process GO:0002252 321 0.311
Mouse
positive regulation of adaptive immune response GO:0002821 61 0.310
regulation of lymphocyte activation GO:0051249 240 0.307
Mouse
cellular metal ion homeostasis GO:0006875 151 0.302
t cell selection GO:0045058 34 0.302
Mouse
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.298
response to lipopolysaccharide GO:0032496 128 0.292
organonitrogen compound catabolic process GO:1901565 264 0.280
regulation of protein kinase activity GO:0045859 232 0.275
skin development GO:0043588 220 0.274
Mouse
negative regulation of phosphorylation GO:0042326 166 0.273
cellular ion homeostasis GO:0006873 165 0.267
regulation of leukocyte differentiation GO:1902105 159 0.258
Mouse
regulation of cell cycle GO:0051726 281 0.257
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.252
negative regulation of protein phosphorylation GO:0001933 126 0.252
hematopoietic progenitor cell differentiation GO:0002244 143 0.249
negative regulation of phosphate metabolic process GO:0045936 184 0.247
regulation of t cell activation GO:0050863 170 0.244
Mouse
cell adhesion GO:0007155 329 0.243
cytokine mediated signaling pathway GO:0019221 115 0.242
Mouse
negative regulation of lymphocyte activation GO:0051250 91 0.242
Mouse
positive regulation of cell development GO:0010720 237 0.241
regulation of lymphocyte differentiation GO:0045619 107 0.239
Mouse
positive regulation of protein modification process GO:0031401 299 0.238
myeloid cell homeostasis GO:0002262 114 0.238
positive regulation of t cell differentiation GO:0045582 52 0.237
regulation of cell adhesion GO:0030155 154 0.235
defense response to protozoan GO:0042832 25 0.230
cellular chemical homeostasis GO:0055082 215 0.230
negative regulation of cell proliferation GO:0008285 296 0.229
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.227
cellular amine metabolic process GO:0044106 44 0.218
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.216
actin filament organization GO:0007015 113 0.215
positive regulation of programmed cell death GO:0043068 218 0.213
regulation of cellular amino acid metabolic process GO:0006521 5 0.213
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.213
calcium ion transport GO:0006816 159 0.212
positive regulation of kinase activity GO:0033674 155 0.211
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.210
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.209
Mouse
positive regulation of cell death GO:0010942 224 0.208
negative regulation of defense response to virus by host GO:0050689 1 0.207
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.200
epidermis development GO:0008544 187 0.199
Mouse
cellular amino acid metabolic process GO:0006520 103 0.197
b cell homeostasis GO:0001782 34 0.196
extrinsic apoptotic signaling pathway GO:0097191 126 0.192
organelle assembly GO:0070925 177 0.191
negative regulation of cellular protein metabolic process GO:0032269 247 0.188
innate immune response GO:0045087 157 0.185
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.180
cellular homeostasis GO:0019725 240 0.177
antigen processing and presentation of exogenous peptide antigen GO:0002478 21 0.176
negative regulation of t cell differentiation GO:0045581 23 0.173
Mouse
antigen processing and presentation GO:0019882 47 0.168
t cell differentiation in thymus GO:0033077 77 0.167
cellular response to molecule of bacterial origin GO:0071219 83 0.167
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.166
lymphocyte homeostasis GO:0002260 64 0.162
positive regulation of organelle organization GO:0010638 128 0.160
positive regulation of interferon alpha production GO:0032727 4 0.160
Mouse
regulation of organelle organization GO:0033043 289 0.159
positive regulation of t cell activation GO:0050870 101 0.155
positive regulation of cellular amine metabolic process GO:0033240 5 0.154
peptidyl amino acid modification GO:0018193 336 0.154
Mouse
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.153
glycosyl compound catabolic process GO:1901658 206 0.152
b cell receptor signaling pathway GO:0050853 20 0.152
regulation of response to biotic stimulus GO:0002831 38 0.152
Mouse
cell chemotaxis GO:0060326 81 0.151
nucleoside triphosphate catabolic process GO:0009143 205 0.150
response to organic cyclic compound GO:0014070 198 0.149
Mouse
regulation of myd88 dependent toll like receptor signaling pathway GO:0034124 2 0.149
Mouse
purine nucleoside metabolic process GO:0042278 241 0.145
cell substrate adhesion GO:0031589 130 0.144
leukocyte mediated cytotoxicity GO:0001909 62 0.143
chromatin organization GO:0006325 206 0.142
Mouse
multicellular organism growth GO:0035264 161 0.142
release of sequestered calcium ion into cytosol GO:0051209 42 0.142
positive regulation of type i interferon mediated signaling pathway GO:0060340 4 0.141
Mouse
negative regulation of kinase activity GO:0033673 81 0.140
b cell proliferation GO:0042100 53 0.140
stem cell differentiation GO:0048863 268 0.140
organic cyclic compound catabolic process GO:1901361 295 0.140
negative regulation of lymphocyte differentiation GO:0045620 32 0.139
Mouse
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.139
Mouse
ribonucleoside catabolic process GO:0042454 206 0.137
regulation of transferase activity GO:0051338 263 0.137
epithelial tube morphogenesis GO:0060562 303 0.137
regulation of adaptive immune response GO:0002819 90 0.136
myeloid leukocyte activation GO:0002274 83 0.134
Mouse
positive regulation of cell activation GO:0050867 158 0.133
positive t cell selection GO:0043368 23 0.132
Mouse
b cell mediated immunity GO:0019724 71 0.132
Mouse
regulation of neutrophil differentiation GO:0045658 2 0.132
protein localization to organelle GO:0033365 185 0.130
negative regulation of cell activation GO:0050866 111 0.129
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.128
programmed necrotic cell death GO:0097300 28 0.128
Mouse
morphogenesis of a branching structure GO:0001763 203 0.128
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.127
Mouse
central nervous system neuron differentiation GO:0021953 162 0.126
glycosyl compound metabolic process GO:1901657 246 0.126
antigen processing and presentation of peptide antigen GO:0048002 29 0.126
purine ribonucleotide metabolic process GO:0009150 290 0.125
ribonucleoside triphosphate metabolic process GO:0009199 220 0.125
response to organonitrogen compound GO:0010243 246 0.124
cellular calcium ion homeostasis GO:0006874 119 0.123
purine nucleoside triphosphate metabolic process GO:0009144 226 0.122
regulation of kinase activity GO:0043549 249 0.121
positive regulation of hydrolase activity GO:0051345 148 0.120
aromatic compound catabolic process GO:0019439 286 0.119
dephosphorylation GO:0016311 129 0.118
muscle cell differentiation GO:0042692 261 0.118
apoptotic signaling pathway GO:0097190 306 0.116
purine nucleoside triphosphate catabolic process GO:0009146 203 0.115
carbohydrate derivative catabolic process GO:1901136 231 0.115
regulation of cellular component size GO:0032535 121 0.114
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.113
posttranscriptional regulation of gene expression GO:0010608 155 0.112
cellular response to growth factor stimulus GO:0071363 197 0.112
defense response to bacterium GO:0042742 119 0.111
cd4 positive alpha beta t cell activation GO:0035710 45 0.110
Mouse
ribose phosphate metabolic process GO:0019693 291 0.109
t helper cell differentiation GO:0042093 28 0.109
Mouse
divalent inorganic cation homeostasis GO:0072507 138 0.109
developmental maturation GO:0021700 193 0.108
regulation of metal ion transport GO:0010959 106 0.107
interspecies interaction between organisms GO:0044419 83 0.106
axonogenesis GO:0007409 274 0.106
macromolecule methylation GO:0043414 120 0.106
Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.105
regulation of t cell proliferation GO:0042129 92 0.104
Mouse
cytoplasmic transport GO:0016482 234 0.104
divalent metal ion transport GO:0070838 172 0.104
nucleoside catabolic process GO:0009164 206 0.103
glycoprotein metabolic process GO:0009100 116 0.102
reactive oxygen species metabolic process GO:0072593 84 0.102
maintenance of location GO:0051235 89 0.101
erythrocyte differentiation GO:0030218 88 0.101
regulation of actin filament based process GO:0032970 99 0.100
purine ribonucleotide catabolic process GO:0009154 208 0.100
molting cycle GO:0042303 90 0.100
positive regulation of apoptotic process GO:0043065 217 0.098
regulation of neuron apoptotic process GO:0043523 122 0.098
t cell receptor signaling pathway GO:0050852 46 0.098
regulation of apoptotic signaling pathway GO:2001233 197 0.098
sequestering of metal ion GO:0051238 19 0.095
cytokine biosynthetic process GO:0042089 68 0.095
Mouse
regulation of protein complex assembly GO:0043254 83 0.094
purine containing compound metabolic process GO:0072521 311 0.094
single organism cell adhesion GO:0098602 156 0.094
lymphocyte apoptotic process GO:0070227 54 0.093
ribonucleoside metabolic process GO:0009119 245 0.093
cytosolic calcium ion transport GO:0060401 48 0.092
defense response to virus GO:0051607 68 0.091
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.089
regulation of innate immune response GO:0045088 91 0.089
Mouse
cellular lipid metabolic process GO:0044255 323 0.089
angiogenesis GO:0001525 201 0.089
necrotic cell death GO:0070265 30 0.088
Mouse
phagocytosis GO:0006909 66 0.088
b cell apoptotic process GO:0001783 19 0.088
leukocyte homeostasis GO:0001776 79 0.087
regulation of homeostatic process GO:0032844 182 0.087
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.086
cellular response to organonitrogen compound GO:0071417 145 0.086
forebrain development GO:0030900 302 0.085
purine ribonucleoside metabolic process GO:0046128 241 0.085
keratinocyte differentiation GO:0030216 48 0.084
Mouse
ras protein signal transduction GO:0007265 77 0.084
ribonucleoside triphosphate catabolic process GO:0009203 199 0.084
cellular response to hormone stimulus GO:0032870 150 0.084
female sex differentiation GO:0046660 84 0.084
nucleotide catabolic process GO:0009166 217 0.083
calcium ion homeostasis GO:0055074 127 0.083
negative regulation of cellular component organization GO:0051129 194 0.083
regulation of purine nucleotide metabolic process GO:1900542 169 0.082
cellular macromolecule catabolic process GO:0044265 206 0.082
regulation of membrane potential GO:0042391 192 0.082
positive regulation of gtp catabolic process GO:0033126 85 0.082
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.082
immunoglobulin mediated immune response GO:0016064 69 0.081
Mouse
morphogenesis of a branching epithelium GO:0061138 193 0.081
response to hypoxia GO:0001666 58 0.081
positive regulation of cellular component biogenesis GO:0044089 94 0.080
pyrimidine containing compound catabolic process GO:0072529 3 0.080
response to ionizing radiation GO:0010212 42 0.080
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.080
Mouse
regulation of interleukin 4 biosynthetic process GO:0045402 3 0.080
negative regulation of b cell activation GO:0050869 27 0.079
cell activation involved in immune response GO:0002263 126 0.079
Mouse
rho protein signal transduction GO:0007266 32 0.079
regulation of leukocyte apoptotic process GO:2000106 56 0.079
purine nucleotide catabolic process GO:0006195 211 0.078
myeloid dendritic cell differentiation GO:0043011 16 0.077
Mouse
cytosolic calcium ion homeostasis GO:0051480 70 0.077
sensory organ morphogenesis GO:0090596 242 0.076
protein methylation GO:0006479 81 0.076
Mouse
cellular response to biotic stimulus GO:0071216 92 0.076
nucleoside triphosphate metabolic process GO:0009141 230 0.076
negative regulation of cytokine production GO:0001818 84 0.074
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.074
regulation of b cell apoptotic process GO:0002902 13 0.074
guanosine containing compound metabolic process GO:1901068 144 0.074
cell fate commitment GO:0045165 210 0.073
Mouse
germ cell development GO:0007281 185 0.073
camera type eye development GO:0043010 266 0.073
organic hydroxy compound metabolic process GO:1901615 203 0.073
renal system development GO:0072001 225 0.072
erk1 and erk2 cascade GO:0070371 77 0.072
cellular response to extracellular stimulus GO:0031668 81 0.072
negative regulation of homeostatic process GO:0032845 71 0.072
positive regulation of cell motility GO:2000147 116 0.071
tissue homeostasis GO:0001894 115 0.071
regulation of defense response GO:0031347 233 0.071
Mouse
small gtpase mediated signal transduction GO:0007264 97 0.071
dna metabolic process GO:0006259 303 0.071
regulation of lymphocyte apoptotic process GO:0070228 41 0.070
response to oxygen levels GO:0070482 62 0.070
negative regulation of myeloid cell differentiation GO:0045638 38 0.070
regulation of striated muscle cell differentiation GO:0051153 81 0.070
negative regulation of lymphocyte proliferation GO:0050672 45 0.070
cation homeostasis GO:0055080 212 0.069
calcium ion transport into cytosol GO:0060402 48 0.069
organophosphate catabolic process GO:0046434 232 0.069
regulation of ion transport GO:0043269 215 0.068
regulation of cell growth GO:0001558 91 0.068
positive regulation of smooth muscle cell migration GO:0014911 4 0.068
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.068
cytokine secretion GO:0050663 72 0.068
peptidyl lysine modification GO:0018205 77 0.068
Mouse
tissue remodeling GO:0048771 102 0.067
regulation of cell shape GO:0008360 39 0.067
t cell mediated immunity GO:0002456 50 0.067
cell type specific apoptotic process GO:0097285 268 0.067
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.066
Mouse
rhythmic process GO:0048511 174 0.066
negative regulation of regulatory t cell differentiation GO:0045590 2 0.066
Mouse
muscle cell migration GO:0014812 19 0.065
regulation of ras protein signal transduction GO:0046578 114 0.065
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.065
regulation of myeloid cell differentiation GO:0045637 96 0.065
regulation of binding GO:0051098 111 0.065
Mouse
b cell activation involved in immune response GO:0002312 50 0.065
male gamete generation GO:0048232 285 0.064
regulation of erythrocyte differentiation GO:0045646 23 0.064
positive regulation of defense response GO:0031349 124 0.064
Mouse
ear development GO:0043583 200 0.064
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.064
heterocycle catabolic process GO:0046700 280 0.063
germinal center formation GO:0002467 16 0.063
t cell activation involved in immune response GO:0002286 43 0.063
Mouse
axon guidance GO:0007411 141 0.063
internal protein amino acid acetylation GO:0006475 42 0.063
Mouse
regulation of hormone levels GO:0010817 211 0.063
nucleotide metabolic process GO:0009117 332 0.062
response to molecule of bacterial origin GO:0002237 143 0.062
response to amino acid GO:0043200 37 0.062
regulation of b cell proliferation GO:0030888 39 0.062
nk t cell differentiation GO:0001865 8 0.062
anatomical structure homeostasis GO:0060249 145 0.061
lymphocyte activation involved in immune response GO:0002285 93 0.061
Mouse
positive regulation of cytokine production GO:0001819 174 0.061
cellular response to cytokine stimulus GO:0071345 189 0.061
Mouse
myeloid cell differentiation GO:0030099 233 0.061
sequestering of calcium ion GO:0051208 18 0.061
glomerulus development GO:0032835 40 0.060
positive regulation of b cell proliferation GO:0030890 24 0.060
regulation of epithelial cell proliferation GO:0050678 141 0.060
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.059
gtp metabolic process GO:0046039 144 0.059
alpha beta t cell lineage commitment GO:0002363 7 0.059
Mouse
regulation of actin cytoskeleton organization GO:0032956 84 0.059
regulation of anatomical structure size GO:0090066 178 0.059
cell maturation GO:0048469 127 0.059
positive regulation of protein phosphorylation GO:0001934 242 0.059
regulation of alpha beta t cell differentiation GO:0046637 35 0.058
positive regulation of innate immune response GO:0045089 80 0.058
Mouse
regulation of gtp catabolic process GO:0033124 113 0.058
regulation of alpha beta t cell proliferation GO:0046640 18 0.057
Mouse
negative regulation of organelle organization GO:0010639 90 0.057
neuron apoptotic process GO:0051402 142 0.057
response to transforming growth factor beta GO:0071559 88 0.057
leukocyte migration GO:0050900 124 0.057
response to peptide GO:1901652 136 0.057
ribonucleotide metabolic process GO:0009259 291 0.057
thymus development GO:0048538 41 0.057
cellular response to lipopolysaccharide GO:0071222 77 0.056
purine nucleoside catabolic process GO:0006152 205 0.056
positive regulation of leukocyte apoptotic process GO:2000108 21 0.056
branching morphogenesis of an epithelial tube GO:0048754 159 0.056
negative regulation of intracellular signal transduction GO:1902532 167 0.056
production of molecular mediator of immune response GO:0002440 103 0.056
purine nucleotide metabolic process GO:0006163 302 0.056
negative regulation of molecular function GO:0044092 258 0.056
positive regulation of mapk cascade GO:0043410 170 0.055
regulation of reactive oxygen species metabolic process GO:2000377 40 0.055
ovulation cycle GO:0042698 59 0.055
regulation of protein serine threonine kinase activity GO:0071900 157 0.055
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.055
membrane organization GO:0061024 245 0.055
regulation of myotube differentiation GO:0010830 62 0.054
myotube differentiation GO:0014902 105 0.054
protein autophosphorylation GO:0046777 61 0.054
kidney development GO:0001822 213 0.054
thymic t cell selection GO:0045061 22 0.053
pyrimidine nucleoside catabolic process GO:0046135 1 0.053
response to ethanol GO:0045471 18 0.053
hormone metabolic process GO:0042445 86 0.052
divalent inorganic cation transport GO:0072511 178 0.051
muscle tissue development GO:0060537 308 0.051
dendritic cell differentiation GO:0097028 26 0.050
Mouse
regulation of cd8 positive alpha beta t cell proliferation GO:2000564 1 0.050
Mouse
positive regulation of nervous system development GO:0051962 221 0.050
regulation of intracellular transport GO:0032386 159 0.050
viral life cycle GO:0019058 36 0.050
developmental programmed cell death GO:0010623 41 0.050
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.049
Mouse
chromatin modification GO:0016568 187 0.049
Mouse
regulation of nucleotide catabolic process GO:0030811 122 0.049
histone acetylation GO:0016573 41 0.049
Mouse
negative regulation of synapse assembly GO:0051964 3 0.049
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.049
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 5 0.049
guanosine containing compound catabolic process GO:1901069 144 0.049
response to acid chemical GO:0001101 111 0.049
regulation of cellular catabolic process GO:0031329 242 0.048
regulation of mitotic cell cycle phase transition GO:1901990 73 0.048
regulation of interferon alpha production GO:0032647 5 0.048
Mouse
positive thymic t cell selection GO:0045059 13 0.048
response to platelet derived growth factor GO:0036119 6 0.047
response to alcohol GO:0097305 48 0.047
homotypic cell cell adhesion GO:0034109 28 0.047
protein alkylation GO:0008213 81 0.047
Mouse
regulation of neuron differentiation GO:0045664 281 0.047
blood vessel morphogenesis GO:0048514 285 0.047
positive regulation of map kinase activity GO:0043406 84 0.047
viral process GO:0016032 41 0.046
response to extracellular stimulus GO:0009991 127 0.046
protein localization to nucleus GO:0034504 121 0.046
regulation of purine nucleotide catabolic process GO:0033121 122 0.045
cellular protein catabolic process GO:0044257 155 0.045
t cell apoptotic process GO:0070231 39 0.045
endocytosis GO:0006897 168 0.045
positive regulation of protein complex assembly GO:0031334 45 0.045
cellular divalent inorganic cation homeostasis GO:0072503 127 0.045
dna modification GO:0006304 50 0.045
response to peptide hormone GO:0043434 127 0.045
myeloid leukocyte differentiation GO:0002573 119 0.044
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.044
regulation of germinal center formation GO:0002634 10 0.044
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.044
nucleoside phosphate metabolic process GO:0006753 338 0.044
multicellular organismal homeostasis GO:0048871 164 0.043
positive regulation of phospholipase activity GO:0010518 3 0.043
glucose homeostasis GO:0042593 128 0.043
cellular protein complex assembly GO:0043623 116 0.042
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.042
neuron projection guidance GO:0097485 141 0.042
response to drug GO:0042493 75 0.042
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.042
response to oxidative stress GO:0006979 123 0.042
digestive system development GO:0055123 200 0.042
positive regulation of cell migration GO:0030335 109 0.042
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.042
metanephros development GO:0001656 79 0.042
antigen processing and presentation of exogenous antigen GO:0019884 26 0.042
ribonucleotide catabolic process GO:0009261 208 0.042
carbohydrate metabolic process GO:0005975 230 0.042
cd8 positive alpha beta t cell differentiation GO:0043374 9 0.041
Mouse
nucleoside phosphate catabolic process GO:1901292 222 0.041
positive regulation of b cell activation GO:0050871 49 0.041
regulation of chromatin modification GO:1903308 57 0.041
defense response to other organism GO:0098542 197 0.041
regulation of cytoskeleton organization GO:0051493 122 0.041
positive regulation of mammary gland involution GO:1903521 4 0.041
actin filament bundle assembly GO:0051017 40 0.041
positive regulation of myeloid cell differentiation GO:0045639 43 0.041
g protein coupled receptor signaling pathway GO:0007186 243 0.041
gtp catabolic process GO:0006184 143 0.041
nucleoside metabolic process GO:0009116 246 0.041
protein modification by small protein conjugation or removal GO:0070647 207 0.041
positive regulation of binding GO:0051099 49 0.040
Mouse
protein modification by small protein conjugation GO:0032446 187 0.039
macromolecule catabolic process GO:0009057 281 0.039
regulation of cellular component biogenesis GO:0044087 181 0.039
development of primary male sexual characteristics GO:0046546 88 0.039
response to inorganic substance GO:0010035 96 0.039
mammary gland epithelium development GO:0061180 65 0.039
Mouse
cellular response to external stimulus GO:0071496 88 0.038
negative regulation of transferase activity GO:0051348 85 0.038
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.038
Mouse
intracellular protein transport GO:0006886 204 0.038
adherens junction organization GO:0034332 28 0.038
mammary gland duct morphogenesis GO:0060603 38 0.038
microtubule cytoskeleton organization GO:0000226 157 0.038
carbohydrate derivative biosynthetic process GO:1901137 183 0.038
cellular response to dna damage stimulus GO:0006974 207 0.038
histone h3 acetylation GO:0043966 14 0.038
Mouse
t helper cell lineage commitment GO:0002295 6 0.038
Mouse
regulation of mitotic cell cycle GO:0007346 126 0.038
mapk cascade GO:0000165 281 0.037
dendrite development GO:0016358 115 0.037
response to type i interferon GO:0034340 12 0.037
Mouse
development of primary sexual characteristics GO:0045137 143 0.037
cerebral cortex development GO:0021987 86 0.037
neutrophil differentiation GO:0030223 3 0.037
mitotic cell cycle GO:0000278 195 0.037
regulation of mapk cascade GO:0043408 248 0.037
g1 s transition of mitotic cell cycle GO:0000082 57 0.036
regulation of homotypic cell cell adhesion GO:0034110 13 0.036
cellular component assembly involved in morphogenesis GO:0010927 139 0.036
antigen processing and presentation of exogenous peptide antigen via mhc class ii GO:0019886 14 0.036
transmembrane transport GO:0055085 412 0.036
regulation of alpha beta t cell activation GO:0046634 53 0.036
Mouse
regulation of cell projection organization GO:0031344 206 0.036
positive regulation of response to cytokine stimulus GO:0060760 11 0.036
Mouse
granulocyte chemotaxis GO:0071621 39 0.036
purine ribonucleoside catabolic process GO:0046130 205 0.036
spermatogenesis GO:0007283 284 0.035
cd4 positive alpha beta t cell lineage commitment GO:0043373 6 0.035
Mouse
regulation of neuron projection development GO:0010975 169 0.035
positive regulation of gtpase activity GO:0043547 85 0.035
carbohydrate homeostasis GO:0033500 128 0.035
extracellular matrix organization GO:0030198 147 0.035
ovarian follicle development GO:0001541 40 0.035
regulation of actin polymerization or depolymerization GO:0008064 45 0.035
positive regulation of cytokine biosynthetic process GO:0042108 40 0.035
Mouse
positive regulation of alpha beta t cell activation GO:0046635 39 0.035
morphogenesis of embryonic epithelium GO:0016331 159 0.035
histone modification GO:0016570 159 0.034
Mouse
protein catabolic process GO:0030163 221 0.034
nephron development GO:0072006 109 0.034
regulation of organ morphogenesis GO:2000027 144 0.034
regulation of leukocyte mediated immunity GO:0002703 104 0.034
positive regulation of behavior GO:0048520 40 0.034
regulation of myeloid leukocyte differentiation GO:0002761 58 0.034
dendritic cell apoptotic process GO:0097048 3 0.034

Irf8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.396
disease of anatomical entity DOID:7 0 0.396
primary immunodeficiency disease DOID:612 0 0.157
b cell deficiency DOID:2115 0 0.040
hematopoietic system disease DOID:74 0 0.037