Mus musculus

35 known processes

Top1

topoisomerase (DNA) I

(Aliases: D130064I21Rik,Top-1,AI467334)

Top1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular protein metabolic process GO:0032269 247 0.131
rna processing GO:0006396 105 0.120
gonad development GO:0008406 141 0.100
Worm
translation GO:0006412 93 0.084
rna splicing GO:0008380 54 0.083
germ cell development GO:0007281 185 0.074
Worm Fly
regulation of rna splicing GO:0043484 37 0.067
cellular amino acid metabolic process GO:0006520 103 0.066
protein ubiquitination GO:0016567 171 0.058
organelle fission GO:0048285 170 0.054
Yeast Worm
chromosome organization involved in meiosis GO:0070192 39 0.045
posttranscriptional regulation of gene expression GO:0010608 155 0.045
epithelial cell development GO:0002064 159 0.044
spermatogenesis GO:0007283 284 0.043
ribonucleoprotein complex localization GO:0071166 1 0.043
meiotic nuclear division GO:0007126 115 0.043
Worm
mrna metabolic process GO:0016071 84 0.041
regulation of mrna splicing via spliceosome GO:0048024 32 0.040
chromatin modification GO:0016568 187 0.039
Human
leukocyte differentiation GO:0002521 342 0.037
regulation of kinase activity GO:0043549 249 0.037
oocyte construction GO:0007308 2 0.036
oocyte axis specification GO:0007309 2 0.036
cation transport GO:0006812 399 0.035
development of primary sexual characteristics GO:0045137 143 0.035
Worm
dna metabolic process GO:0006259 303 0.035
appendage development GO:0048736 166 0.035
cellular ketone metabolic process GO:0042180 84 0.034
regulation of response to wounding GO:1903034 189 0.034
protein modification by small protein conjugation GO:0032446 187 0.033
mrna transport GO:0051028 13 0.033
regulation of proteolysis GO:0030162 164 0.033
regulation of circadian rhythm GO:0042752 58 0.033
cellular macromolecule catabolic process GO:0044265 206 0.032
oxidation reduction process GO:0055114 342 0.032
carbohydrate derivative biosynthetic process GO:1901137 183 0.032
regulation of cellular ketone metabolic process GO:0010565 66 0.031
negative regulation of phosphorylation GO:0042326 166 0.031
nuclear division GO:0000280 158 0.030
Yeast Worm
oogenesis GO:0048477 56 0.030
Worm Fly
positive regulation of macroautophagy GO:0016239 3 0.030
limb development GO:0060173 166 0.030
modification dependent macromolecule catabolic process GO:0043632 133 0.030
amine metabolic process GO:0009308 45 0.030
chromatin organization GO:0006325 206 0.029
Human Yeast
negative regulation of molecular function GO:0044092 258 0.029
rna interference GO:0016246 2 0.028
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.028
male gamete generation GO:0048232 285 0.028
rhythmic process GO:0048511 174 0.028
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.028
cellular amine metabolic process GO:0044106 44 0.028
mrna processing GO:0006397 63 0.027
cellular response to oxidative stress GO:0034599 76 0.027
t cell activation GO:0042110 289 0.027
regulation of organelle organization GO:0033043 289 0.027
cardiac muscle cell contraction GO:0086003 7 0.026
cajal body organization GO:0030576 1 0.026
chromosome segregation GO:0007059 48 0.026
Yeast Worm Fly
regulation of cell cycle GO:0051726 281 0.024
regulation of translation GO:0006417 71 0.024
organelle localization GO:0051640 179 0.024
Yeast
glucose homeostasis GO:0042593 128 0.024
transdifferentiation GO:0060290 1 0.023
covalent chromatin modification GO:0016569 163 0.023
ear development GO:0043583 200 0.023
organonitrogen compound biosynthetic process GO:1901566 192 0.023
sensory perception GO:0007600 245 0.023
cellular homeostasis GO:0019725 240 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.023
skeletal system development GO:0001501 356 0.023
regulation of mrna processing GO:0050684 41 0.023
multicellular organism growth GO:0035264 161 0.023
macromolecule catabolic process GO:0009057 281 0.023
response to oxidative stress GO:0006979 123 0.022
compound eye development GO:0048749 1 0.022
regulation of protein kinase activity GO:0045859 232 0.022
rna splicing via transesterification reactions GO:0000375 43 0.022
regulation of protein localization GO:0032880 231 0.021
cognition GO:0050890 149 0.021
negative regulation of protein metabolic process GO:0051248 282 0.021
heterocycle catabolic process GO:0046700 280 0.021
alternative mrna splicing via spliceosome GO:0000380 12 0.021
pole plasm assembly GO:0007315 2 0.021
appendage morphogenesis GO:0035107 149 0.021
muscle cell differentiation GO:0042692 261 0.021
regulation of transferase activity GO:0051338 263 0.020
negative regulation of phosphate metabolic process GO:0045936 184 0.020
embryonic skeletal system development GO:0048706 120 0.020
response to radiation GO:0009314 165 0.020
meiosis i GO:0007127 60 0.020
segmentation GO:0035282 93 0.020
neuron apoptotic process GO:0051402 142 0.019
nitrogen compound transport GO:0071705 271 0.019
regulation of chromatin silencing GO:0031935 2 0.019
transmembrane transport GO:0055085 412 0.019
circadian rhythm GO:0007623 114 0.019
Human
regulation of protein processing GO:0070613 96 0.019
mrna splicing via spliceosome GO:0000398 43 0.019
locomotory behavior GO:0007626 195 0.019
negative regulation of immune system process GO:0002683 209 0.018
heart morphogenesis GO:0003007 178 0.018
regulation of cell motility GO:2000145 236 0.018
regulation of neuron differentiation GO:0045664 281 0.018
nuclear export GO:0051168 34 0.018
spermatid differentiation GO:0048515 115 0.018
glycoprotein biosynthetic process GO:0009101 89 0.018
glycoprotein metabolic process GO:0009100 116 0.018
nuclear transport GO:0051169 139 0.018
immune effector process GO:0002252 321 0.018
regulation of system process GO:0044057 200 0.018
carbohydrate homeostasis GO:0033500 128 0.018
cellular chemical homeostasis GO:0055082 215 0.018
cell type specific apoptotic process GO:0097285 268 0.018
microtubule based process GO:0007017 236 0.018
regulation of cellular amine metabolic process GO:0033238 20 0.018
regulation of transcription by chromatin organization GO:0034401 0 0.018
regulation of cell projection organization GO:0031344 206 0.017
negative regulation of lymphocyte activation GO:0051250 91 0.017
meiotic cell cycle GO:0051321 122 0.017
Worm
regulation of nuclear division GO:0051783 56 0.017
carboxylic acid biosynthetic process GO:0046394 86 0.017
regulation of protein catabolic process GO:0042176 108 0.017
muscle tissue development GO:0060537 308 0.017
protein modification by small protein conjugation or removal GO:0070647 207 0.017
negative regulation of cellular component organization GO:0051129 194 0.017
protein maturation GO:0051604 176 0.017
aromatic compound catabolic process GO:0019439 286 0.017
spermatid development GO:0007286 108 0.017
regulation of t cell activation GO:0050863 170 0.017
neural precursor cell proliferation GO:0061351 121 0.017
dendrite development GO:0016358 115 0.017
regulation of protein maturation GO:1903317 96 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
negative regulation of kinase activity GO:0033673 81 0.016
protein dna complex subunit organization GO:0071824 28 0.016
regulation of cell division GO:0051302 76 0.016
nucleoside metabolic process GO:0009116 246 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.016
fat cell differentiation GO:0045444 160 0.016
cation transmembrane transport GO:0098655 266 0.016
mitotic cell cycle GO:0000278 195 0.016
Yeast
actin mediated cell contraction GO:0070252 15 0.016
establishment of rna localization GO:0051236 18 0.016
positive regulation of mapk cascade GO:0043410 170 0.016
regulation of binding GO:0051098 111 0.016
cell fate commitment GO:0045165 210 0.016
positive regulation of organelle organization GO:0010638 128 0.016
actin cytoskeleton organization GO:0030036 220 0.015
cell division GO:0051301 120 0.015
intracellular mrna localization GO:0008298 4 0.015
carbohydrate metabolic process GO:0005975 230 0.015
regulation of protein serine threonine kinase activity GO:0071900 157 0.015
positive regulation of cellular amine metabolic process GO:0033240 5 0.015
modification dependent protein catabolic process GO:0019941 133 0.015
cellular nitrogen compound catabolic process GO:0044270 280 0.015
microtubule cytoskeleton organization GO:0000226 157 0.015
neural tube development GO:0021915 160 0.015
muscle contraction GO:0006936 101 0.015
stem cell fate specification GO:0048866 3 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
ribonucleoprotein complex subunit organization GO:0071826 28 0.015
morphogenesis of embryonic epithelium GO:0016331 159 0.015
neural tube closure GO:0001843 90 0.014
inter male aggressive behavior GO:0002121 3 0.014
cellular lipid metabolic process GO:0044255 323 0.014
lipid biosynthetic process GO:0008610 179 0.014
rna transport GO:0050658 18 0.014
organelle assembly GO:0070925 177 0.014
dna integrity checkpoint GO:0031570 28 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.014
female sex determination GO:0030237 1 0.014
sulfur compound metabolic process GO:0006790 100 0.014
positive regulation of proteolysis GO:0045862 85 0.014
small molecule biosynthetic process GO:0044283 132 0.014
endothelial cell morphogenesis GO:0001886 9 0.014
cellular response to insulin stimulus GO:0032869 78 0.014
regulation of cellular response to stress GO:0080135 159 0.014
ossification GO:0001503 216 0.014
digestive tract morphogenesis GO:0048546 147 0.014
maintenance of location GO:0051235 89 0.014
heart process GO:0003015 94 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
regulation of cell migration GO:0030334 219 0.014
sensory perception of light stimulus GO:0050953 54 0.014
negative regulation of transferase activity GO:0051348 85 0.014
endothelium development GO:0003158 45 0.014
nucleobase containing small molecule metabolic process GO:0055086 352 0.013
embryonic appendage morphogenesis GO:0035113 126 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
actin filament based movement GO:0030048 23 0.013
organic acid biosynthetic process GO:0016053 86 0.013
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.013
epithelial cell morphogenesis GO:0003382 41 0.013
protein processing GO:0016485 163 0.013
regulation of ion transport GO:0043269 215 0.013
neuron death GO:0070997 154 0.013
tube closure GO:0060606 91 0.013
angiogenesis GO:0001525 201 0.013
epidermis development GO:0008544 187 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.013
myosin filament organization GO:0031033 3 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
central nervous system neuron differentiation GO:0021953 162 0.013
learning or memory GO:0007611 148 0.013
regulation of angiogenesis GO:0045765 81 0.012
striated muscle myosin thick filament assembly GO:0071688 1 0.012
activation of immune response GO:0002253 138 0.012
establishment of organelle localization GO:0051656 122 0.012
Yeast
jnk cascade GO:0007254 72 0.012
genitalia development GO:0048806 37 0.012
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.012
extracellular structure organization GO:0043062 148 0.012
carbohydrate biosynthetic process GO:0016051 74 0.012
jak stat cascade GO:0007259 42 0.012
endothelial cell development GO:0001885 20 0.012
blood circulation GO:0008015 195 0.012
striated muscle tissue development GO:0014706 293 0.012
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.012
digestive tract development GO:0048565 190 0.012
ribose phosphate metabolic process GO:0019693 291 0.012
learning GO:0007612 98 0.012
chromatin silencing at rdna GO:0000183 3 0.012
Yeast
negative regulation of protein maturation GO:1903318 79 0.012
digestive system development GO:0055123 200 0.012
response to peptide GO:1901652 136 0.012
organelle disassembly GO:1903008 2 0.012
t cell differentiation GO:0030217 174 0.012
negative regulation of cell activation GO:0050866 111 0.012
respiratory system development GO:0060541 190 0.012
regulation of proteasomal protein catabolic process GO:0061136 46 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
mesoderm development GO:0007498 100 0.012
regulation of meiotic cell cycle GO:0051445 34 0.012
regulation of rna export from nucleus GO:0046831 4 0.012
glycosyl compound metabolic process GO:1901657 246 0.011
cell adhesion GO:0007155 329 0.011
positive regulation of nervous system development GO:0051962 221 0.011
striated muscle contraction GO:0006941 45 0.011
cellular response to starvation GO:0009267 57 0.011
carbohydrate derivative catabolic process GO:1901136 231 0.011
positive regulation of cell death GO:0010942 224 0.011
oocyte anterior posterior axis specification GO:0007314 2 0.011
regulation of cell activation GO:0050865 289 0.011
nucleocytoplasmic transport GO:0006913 139 0.011
lipid localization GO:0010876 126 0.011
habituation GO:0046959 3 0.011
cellular response to abiotic stimulus GO:0071214 56 0.011
negative regulation of ossification GO:0030279 49 0.011
endocytosis GO:0006897 168 0.011
Worm
b cell activation GO:0042113 161 0.011
stem cell maintenance GO:0019827 130 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.011
negative regulation of proteolysis GO:0045861 74 0.011
inflammatory response GO:0006954 244 0.011
nucleoside phosphate metabolic process GO:0006753 338 0.011
regulation of nucleoside metabolic process GO:0009118 130 0.011
cell maturation GO:0048469 127 0.011
alpha amino acid metabolic process GO:1901605 59 0.011
negative regulation of protein modification process GO:0031400 163 0.011
intracellular protein transport GO:0006886 204 0.011
regulation of hormone levels GO:0010817 211 0.011
circadian regulation of gene expression GO:0032922 48 0.011
Human
coenzyme biosynthetic process GO:0009108 23 0.011
epithelial tube formation GO:0072175 130 0.011
lymphocyte differentiation GO:0030098 242 0.011
macromolecule deacylation GO:0098732 37 0.011
fatty acid metabolic process GO:0006631 121 0.011
cellular response to cytokine stimulus GO:0071345 189 0.011
negative regulation of mapk cascade GO:0043409 65 0.011
rna localization GO:0006403 23 0.011
tube formation GO:0035148 140 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.011
purine nucleoside triphosphate metabolic process GO:0009144 226 0.010
dephosphorylation GO:0016311 129 0.010
blood vessel morphogenesis GO:0048514 285 0.010
respiratory tube development GO:0030323 167 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
inorganic cation transmembrane transport GO:0098662 207 0.010
regulation of cellular catabolic process GO:0031329 242 0.010
regulation of protein complex assembly GO:0043254 83 0.010
rho protein signal transduction GO:0007266 32 0.010
mapk cascade GO:0000165 281 0.010
forebrain development GO:0030900 302 0.010
peptidyl amino acid modification GO:0018193 336 0.010
mitotic nuclear division GO:0007067 48 0.010
Yeast
ribonucleoprotein complex disassembly GO:0032988 3 0.010
apoptotic signaling pathway GO:0097190 306 0.010
cellular carbohydrate metabolic process GO:0044262 119 0.010
cellular response to organonitrogen compound GO:0071417 145 0.010
histone deubiquitination GO:0016578 2 0.010
negative regulation of cell development GO:0010721 169 0.010
placenta development GO:0001890 140 0.010
regulation of ossification GO:0030278 112 0.010
negative regulation of dna replication GO:0008156 4 0.010
posttranscriptional gene silencing by rna GO:0035194 10 0.010
protein localization to nucleus GO:0034504 121 0.010
circulatory system process GO:0003013 197 0.010
endothelial cell differentiation GO:0045446 41 0.010
nucleotide metabolic process GO:0009117 332 0.010
adult behavior GO:0030534 135 0.010
cell junction assembly GO:0034329 52 0.010

Top1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.011
bone disease DOID:0080001 0 0.011
disease of anatomical entity DOID:7 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011