Mus musculus

81 known processes

Sh2b1

SH2B adaptor protein 1

(Aliases: Sh2bpsm1,Irip,mKIAA1299,SH2-B,C530001K22Rik,AI425885,SH2-Bb)

Sh2b1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular ketone metabolic process GO:0010565 66 0.347
cellular ketone metabolic process GO:0042180 84 0.332
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.317
Mouse Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.297
regulation of cellular amine metabolic process GO:0033238 20 0.276
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.253
compound eye development GO:0048749 1 0.222
cellular amine metabolic process GO:0044106 44 0.198
regulation of cellular amino acid metabolic process GO:0006521 5 0.174
positive regulation of growth hormone receptor signaling pathway GO:0060399 3 0.158
protein autophosphorylation GO:0046777 61 0.155
peptidyl amino acid modification GO:0018193 336 0.151
cellular amino acid metabolic process GO:0006520 103 0.149
amine metabolic process GO:0009308 45 0.147
negative regulation of glycoprotein metabolic process GO:1903019 3 0.141
regionalization GO:0003002 337 0.140
apical constriction GO:0003383 4 0.137
rhythmic process GO:0048511 174 0.137
stem cell differentiation GO:0048863 268 0.124
carbohydrate derivative biosynthetic process GO:1901137 183 0.123
regulation of protein kinase activity GO:0045859 232 0.120
peptidyl tyrosine phosphorylation GO:0018108 143 0.118
regulation of hydrolase activity GO:0051336 246 0.117
activation of janus kinase activity GO:0042976 2 0.116
positive regulation of protein phosphorylation GO:0001934 242 0.115
stem cell development GO:0048864 219 0.105
striated muscle tissue development GO:0014706 293 0.105
response to organonitrogen compound GO:0010243 246 0.104
Mouse Fly
digestive system development GO:0055123 200 0.100
phosphatidylinositol mediated signaling GO:0048015 41 0.094
positive regulation of hydrolase activity GO:0051345 148 0.092
positive regulation of cell death GO:0010942 224 0.092
ras protein signal transduction GO:0007265 77 0.091
dendritic cell cytokine production GO:0002371 3 0.090
positive regulation of apoptotic signaling pathway GO:2001235 95 0.089
leukocyte differentiation GO:0002521 342 0.088
myeloid cell homeostasis GO:0002262 114 0.087
stem cell maintenance GO:0019827 130 0.084
cytokine production GO:0001816 319 0.084
cellular lipid metabolic process GO:0044255 323 0.083
myeloid cell differentiation GO:0030099 233 0.082
urogenital system development GO:0001655 261 0.082
cell fate commitment GO:0045165 210 0.081
cognition GO:0050890 149 0.081
purine ribonucleotide metabolic process GO:0009150 290 0.078
regulation of kinase activity GO:0043549 249 0.077
ameboidal type cell migration GO:0001667 128 0.076
g protein coupled receptor signaling pathway GO:0007186 243 0.076
homeostasis of number of cells GO:0048872 210 0.075
Mouse
positive regulation of programmed cell death GO:0043068 218 0.074
circadian rhythm GO:0007623 114 0.073
negative regulation of cellular component organization GO:0051129 194 0.071
digestive tract development GO:0048565 190 0.071
cellular response to lipid GO:0071396 145 0.071
protein targeting GO:0006605 143 0.070
histone modification GO:0016570 159 0.068
nucleobase containing small molecule metabolic process GO:0055086 352 0.068
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.067
positive regulation of protein modification process GO:0031401 299 0.066
cellular response to organonitrogen compound GO:0071417 145 0.065
Mouse Fly
ribonucleotide metabolic process GO:0009259 291 0.064
positive regulation of kinase activity GO:0033674 155 0.064
regulation of mapk cascade GO:0043408 248 0.064
cellular response to peptide hormone stimulus GO:0071375 92 0.064
Mouse Fly
organic cyclic compound catabolic process GO:1901361 295 0.063
peptidyl tyrosine modification GO:0018212 145 0.063
glycoprotein metabolic process GO:0009100 116 0.062
regulation of embryonic development GO:0045995 71 0.062
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.061
locomotory behavior GO:0007626 195 0.061
blood circulation GO:0008015 195 0.061
regulation of cellular catabolic process GO:0031329 242 0.060
negative regulation of molecular function GO:0044092 258 0.060
t cell activation GO:0042110 289 0.059
gland development GO:0048732 330 0.059
negative regulation of immune system process GO:0002683 209 0.058
regulation of cell motility GO:2000145 236 0.058
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.058
lymphocyte differentiation GO:0030098 242 0.057
actin filament based movement GO:0030048 23 0.057
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.056
calcium ion transport GO:0006816 159 0.056
nucleotide catabolic process GO:0009166 217 0.056
establishment of protein localization to organelle GO:0072594 118 0.056
organonitrogen compound biosynthetic process GO:1901566 192 0.055
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.055
divalent inorganic cation transport GO:0072511 178 0.055
gastrulation GO:0007369 116 0.054
regulation of leukocyte differentiation GO:1902105 159 0.054
regulation of dendritic cell cytokine production GO:0002730 2 0.054
negative regulation of nervous system development GO:0051961 156 0.053
negative regulation of cell development GO:0010721 169 0.053
cellular response to cytokine stimulus GO:0071345 189 0.053
Mouse
regulation of transferase activity GO:0051338 263 0.053
response to interleukin 12 GO:0070671 2 0.053
purine nucleotide metabolic process GO:0006163 302 0.052
cellular homeostasis GO:0019725 240 0.052
regulation of neuron differentiation GO:0045664 281 0.052
positive regulation of cellular catabolic process GO:0031331 148 0.052
protein import GO:0017038 101 0.051
regulation of cell cycle process GO:0010564 160 0.051
response to peptide hormone GO:0043434 127 0.051
Mouse Fly
signal transduction in absence of ligand GO:0038034 55 0.051
nucleotide metabolic process GO:0009117 332 0.050
extrinsic apoptotic signaling pathway GO:0097191 126 0.050
negative regulation of cell proliferation GO:0008285 296 0.050
cytoplasmic transport GO:0016482 234 0.050
inositol lipid mediated signaling GO:0048017 41 0.050
purine containing compound metabolic process GO:0072521 311 0.049
regulation of nucleotide metabolic process GO:0006140 169 0.049
mapk cascade GO:0000165 281 0.049
dna metabolic process GO:0006259 303 0.049
negative regulation of leukocyte differentiation GO:1902106 51 0.049
small gtpase mediated signal transduction GO:0007264 97 0.049
chromatin organization GO:0006325 206 0.048
chromatin modification GO:0016568 187 0.048
cellular response to biotic stimulus GO:0071216 92 0.048
nucleoside phosphate catabolic process GO:1901292 222 0.048
glycoprotein biosynthetic process GO:0009101 89 0.048
response to peptide GO:1901652 136 0.047
Mouse Fly
male gamete generation GO:0048232 285 0.047
negative regulation of intracellular signal transduction GO:1902532 167 0.047
dephosphorylation GO:0016311 129 0.047
regulation of secretion GO:0051046 274 0.046
modification dependent protein catabolic process GO:0019941 133 0.046
purine containing compound catabolic process GO:0072523 213 0.046
regulation of purine nucleotide metabolic process GO:1900542 169 0.046
cellular ion homeostasis GO:0006873 165 0.046
regulation of cell projection organization GO:0031344 206 0.046
regulation of lymphocyte activation GO:0051249 240 0.045
heart morphogenesis GO:0003007 178 0.045
peptide transport GO:0015833 133 0.045
aromatic compound catabolic process GO:0019439 286 0.045
cell type specific apoptotic process GO:0097285 268 0.045
memory GO:0007613 58 0.045
cellular response to peptide GO:1901653 92 0.045
Mouse Fly
cation transport GO:0006812 399 0.045
nitrogen compound transport GO:0071705 271 0.045
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.044
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.044
cellular chemical homeostasis GO:0055082 215 0.044
erythrocyte differentiation GO:0030218 88 0.044
cation homeostasis GO:0055080 212 0.044
calcium ion homeostasis GO:0055074 127 0.043
negative regulation of lymphocyte activation GO:0051250 91 0.043
positive regulation of transferase activity GO:0051347 167 0.043
positive regulation of protein kinase activity GO:0045860 144 0.043
divalent metal ion transport GO:0070838 172 0.042
response to molecule of bacterial origin GO:0002237 143 0.042
negative regulation of cell activation GO:0050866 111 0.042
apoptotic signaling pathway GO:0097190 306 0.041
cellular nitrogen compound catabolic process GO:0044270 280 0.041
protein localization to organelle GO:0033365 185 0.041
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.041
digestive tract morphogenesis GO:0048546 147 0.041
ribose phosphate metabolic process GO:0019693 291 0.041
cellular response to growth factor stimulus GO:0071363 197 0.041
positive regulation of proteolysis GO:0045862 85 0.040
cellular response to lipopolysaccharide GO:0071222 77 0.040
regulation of apoptotic signaling pathway GO:2001233 197 0.040
leukocyte proliferation GO:0070661 172 0.040
nucleoside triphosphate catabolic process GO:0009143 205 0.039
regulation of reactive oxygen species metabolic process GO:2000377 40 0.039
nuclear division GO:0000280 158 0.039
skeletal system development GO:0001501 356 0.038
reactive oxygen species biosynthetic process GO:1903409 8 0.038
t cell differentiation GO:0030217 174 0.038
organophosphate catabolic process GO:0046434 232 0.038
response to lipopolysaccharide GO:0032496 128 0.037
blood vessel morphogenesis GO:0048514 285 0.037
carbohydrate metabolic process GO:0005975 230 0.037
organophosphate biosynthetic process GO:0090407 122 0.037
protein catabolic process GO:0030163 221 0.037
endomembrane system organization GO:0010256 147 0.037
purine nucleoside triphosphate metabolic process GO:0009144 226 0.037
regulation of proteolysis GO:0030162 164 0.037
divalent inorganic cation homeostasis GO:0072507 138 0.036
nucleoside metabolic process GO:0009116 246 0.036
cytosolic calcium ion homeostasis GO:0051480 70 0.036
purine nucleoside catabolic process GO:0006152 205 0.036
jak stat cascade GO:0007259 42 0.035
nucleoside phosphate metabolic process GO:0006753 338 0.035
protein import into nucleus GO:0006606 95 0.035
nuclear transport GO:0051169 139 0.035
organonitrogen compound catabolic process GO:1901565 264 0.035
nucleoside triphosphate metabolic process GO:0009141 230 0.035
spermatogenesis GO:0007283 284 0.035
lateral inhibition GO:0046331 1 0.034
ubiquitin dependent protein catabolic process GO:0006511 129 0.034
regulation of hormone levels GO:0010817 211 0.034
purine nucleoside metabolic process GO:0042278 241 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.034
cellular metal ion homeostasis GO:0006875 151 0.033
morphogenesis of a branching epithelium GO:0061138 193 0.033
ion transmembrane transport GO:0034220 361 0.033
positive regulation of apoptotic process GO:0043065 217 0.033
intracellular protein transport GO:0006886 204 0.033
reactive oxygen species metabolic process GO:0072593 84 0.033
negative regulation of cell projection organization GO:0031345 56 0.032
production of molecular mediator of immune response GO:0002440 103 0.032
response to organic cyclic compound GO:0014070 198 0.032
organelle fission GO:0048285 170 0.032
protein maturation GO:0051604 176 0.031
circulatory system process GO:0003013 197 0.031
regulation of binding GO:0051098 111 0.031
forebrain development GO:0030900 302 0.031
response to oxidative stress GO:0006979 123 0.031
muscle cell differentiation GO:0042692 261 0.031
negative regulation of lymphocyte differentiation GO:0045620 32 0.031
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.031
amide transport GO:0042886 138 0.031
single organism nuclear import GO:1902593 95 0.030
transmembrane transport GO:0055085 412 0.030
immune effector process GO:0002252 321 0.030
cytokine production involved in immune response GO:0002367 34 0.030
regulation of ion transport GO:0043269 215 0.030
positive regulation of nervous system development GO:0051962 221 0.030
heterocycle catabolic process GO:0046700 280 0.030
regulation of jak stat cascade GO:0046425 34 0.030
carbohydrate derivative catabolic process GO:1901136 231 0.030
regulation of t cell activation GO:0050863 170 0.029
covalent chromatin modification GO:0016569 163 0.029
telencephalon development GO:0021537 186 0.029
nucleoside catabolic process GO:0009164 206 0.029
negative regulation of t cell activation GO:0050868 65 0.029
positive regulation of phosphatase activity GO:0010922 4 0.029
negative regulation of cd4 positive alpha beta t cell activation GO:2000515 10 0.029
regulation of dendritic cell apoptotic process GO:2000668 3 0.029
nucleocytoplasmic transport GO:0006913 139 0.028
respiratory system development GO:0060541 190 0.028
b cell differentiation GO:0030183 78 0.028
peptide hormone secretion GO:0030072 109 0.028
cellular response to molecule of bacterial origin GO:0071219 83 0.028
response to growth factor GO:0070848 198 0.028
regulation of t helper 1 cell differentiation GO:0045625 7 0.028
sensory perception GO:0007600 245 0.027
regulation of membrane potential GO:0042391 192 0.027
reactive nitrogen species metabolic process GO:2001057 0 0.027
regulation of neuron projection development GO:0010975 169 0.027
negative regulation of glycoprotein biosynthetic process GO:0010561 3 0.027
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.027
cellular divalent inorganic cation homeostasis GO:0072503 127 0.027
positive regulation of cell migration GO:0030335 109 0.027
regulation of cell activation GO:0050865 289 0.027
myeloid leukocyte differentiation GO:0002573 119 0.027
metal ion homeostasis GO:0055065 189 0.027
muscle tissue development GO:0060537 308 0.027
regulation of system process GO:0044057 200 0.027
defense response to virus GO:0051607 68 0.027
regulation of lymphocyte differentiation GO:0045619 107 0.027
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.027
ribonucleoside metabolic process GO:0009119 245 0.027
asymmetric neuroblast division GO:0055059 1 0.026
cellular macromolecule catabolic process GO:0044265 206 0.026
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.026
cytokine mediated signaling pathway GO:0019221 115 0.026
Mouse
cellular response to acid chemical GO:0071229 68 0.026
protein localization to nucleus GO:0034504 121 0.025
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.025
ossification GO:0001503 216 0.025
positive regulation of phosphoprotein phosphatase activity GO:0032516 1 0.025
neural precursor cell proliferation GO:0061351 121 0.024
negative regulation of cytokine production GO:0001818 84 0.024
spermatid differentiation GO:0048515 115 0.024
cd4 positive alpha beta t cell activation GO:0035710 45 0.024
respiratory tube development GO:0030323 167 0.024
exocytosis GO:0006887 121 0.024
learning or memory GO:0007611 148 0.024
cerebral cortex development GO:0021987 86 0.024
heart contraction GO:0060047 93 0.024
cellular calcium ion homeostasis GO:0006874 119 0.024
regulation of cell migration GO:0030334 219 0.024
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.024
macromolecule catabolic process GO:0009057 281 0.023
lung development GO:0030324 164 0.023
peptide secretion GO:0002790 114 0.023
regulation of intracellular protein transport GO:0033157 82 0.023
lymphocyte homeostasis GO:0002260 64 0.023
Mouse
phosphatidylinositol metabolic process GO:0046488 45 0.023
wnt signaling pathway GO:0016055 188 0.023
regulation of protein transport GO:0051223 163 0.023
alpha beta t cell activation GO:0046631 91 0.023
segmentation GO:0035282 93 0.023
cellular response to hormone stimulus GO:0032870 150 0.023
Mouse Fly
regulation of cellular component biogenesis GO:0044087 181 0.023
nucleotide biosynthetic process GO:0009165 78 0.023
cellular response to organic cyclic compound GO:0071407 87 0.023
microtubule based process GO:0007017 236 0.023
tyrosine phosphorylation of stat protein GO:0007260 23 0.023
mitotic cell cycle GO:0000278 195 0.023
regulation of t helper cell differentiation GO:0045622 14 0.023
positive regulation of mapk cascade GO:0043410 170 0.022
anion transport GO:0006820 177 0.022
positive regulation of dendritic cell apoptotic process GO:2000670 3 0.022
b cell activation GO:0042113 161 0.022
positive regulation of cellular protein catabolic process GO:1903364 34 0.022
alpha beta t cell differentiation GO:0046632 69 0.022
camera type eye development GO:0043010 266 0.022
regulation of secretion by cell GO:1903530 249 0.022
regulation of metal ion transport GO:0010959 106 0.022
neuron migration GO:0001764 122 0.022
purine ribonucleoside metabolic process GO:0046128 241 0.022
positive regulation of neuron differentiation GO:0045666 141 0.022
regulation of homeostatic process GO:0032844 182 0.022
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.022
glycosyl compound catabolic process GO:1901658 206 0.021
regulation of phosphoprotein phosphatase activity GO:0043666 3 0.021
cell activation involved in immune response GO:0002263 126 0.021
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.021
ribonucleoside triphosphate metabolic process GO:0009199 220 0.021
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.021
purine nucleotide catabolic process GO:0006195 211 0.021
axonogenesis GO:0007409 274 0.021
regulation of anatomical structure size GO:0090066 178 0.021
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001269 3 0.021
cellular protein catabolic process GO:0044257 155 0.021
transmission of nerve impulse GO:0019226 76 0.020
lymphocyte activation involved in immune response GO:0002285 93 0.020
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.020
regulation of insulin receptor signaling pathway GO:0046626 21 0.020
Fly
maintenance of location GO:0051235 89 0.020
retina development in camera type eye GO:0060041 119 0.020
epithelial cell development GO:0002064 159 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
cell substrate adhesion GO:0031589 130 0.020
negative regulation of phosphorus metabolic process GO:0010563 184 0.020
hormone secretion GO:0046879 128 0.020
developmental maturation GO:0021700 193 0.020
fatty acid metabolic process GO:0006631 121 0.020
intracellular receptor signaling pathway GO:0030522 74 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
angiogenesis GO:0001525 201 0.020
sensory perception of mechanical stimulus GO:0050954 107 0.020
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.020
positive regulation of protein transport GO:0051222 93 0.020
rho protein signal transduction GO:0007266 32 0.020
asymmetric stem cell division GO:0098722 3 0.020
positive regulation of cell development GO:0010720 237 0.019
negative regulation of immune effector process GO:0002698 55 0.019
negative regulation of neuron differentiation GO:0045665 101 0.019
glycosyl compound metabolic process GO:1901657 246 0.019
regulation of peptide transport GO:0090087 91 0.019
lymphocyte proliferation GO:0046651 164 0.019
response to oxygen levels GO:0070482 62 0.019
negative regulation of cellular amine metabolic process GO:0033239 1 0.019
single organism cell adhesion GO:0098602 156 0.019
regulation of lipid metabolic process GO:0019216 118 0.019
gtp catabolic process GO:0006184 143 0.019
cardiac chamber morphogenesis GO:0003206 93 0.019
regulation of myeloid cell differentiation GO:0045637 96 0.019
mitotic cell cycle process GO:1903047 159 0.019
lipid homeostasis GO:0055088 63 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.019
regulation of cytokine production GO:0001817 266 0.019
inflammatory response GO:0006954 244 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
gliogenesis GO:0042063 141 0.019
regulation of intracellular transport GO:0032386 159 0.019
negative regulation of endothelial cell migration GO:0010596 4 0.019
regulation of cytoskeleton organization GO:0051493 122 0.019
spermatid development GO:0007286 108 0.019
ribonucleoside catabolic process GO:0042454 206 0.018
cyclic nucleotide metabolic process GO:0009187 59 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.018
negative regulation of protein phosphorylation GO:0001933 126 0.018
positive regulation of cell motility GO:2000147 116 0.018
regulation of peptide secretion GO:0002791 77 0.018
ribonucleotide biosynthetic process GO:0009260 59 0.018
actin mediated cell contraction GO:0070252 15 0.018
intrinsic apoptotic signaling pathway GO:0097193 132 0.018
ribonucleotide catabolic process GO:0009261 208 0.018
actin cytoskeleton organization GO:0030036 220 0.018
Mouse
anatomical structure homeostasis GO:0060249 145 0.018
regulation of calcium ion transport GO:0051924 69 0.018
antimicrobial peptide production GO:0002775 2 0.018
embryonic skeletal system development GO:0048706 120 0.018
nuclear import GO:0051170 95 0.018
placenta development GO:0001890 140 0.018
heart process GO:0003015 94 0.018
regulation of protein localization GO:0032880 231 0.018
positive regulation of nucleotide metabolic process GO:0045981 114 0.017
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.017
regulation of production of molecular mediator of immune response GO:0002700 65 0.017
sprouting angiogenesis GO:0002040 26 0.017
positive regulation of protein catabolic process GO:0045732 60 0.017
negative regulation of myeloid cell differentiation GO:0045638 38 0.017
negative regulation of lymphocyte apoptotic process GO:0070229 24 0.017
embryonic appendage morphogenesis GO:0035113 126 0.017
response to light stimulus GO:0009416 135 0.017
positive regulation of organelle organization GO:0010638 128 0.017
positive regulation of ion transport GO:0043270 65 0.017
regulation of antimicrobial humoral response GO:0002759 3 0.017
germ cell development GO:0007281 185 0.017
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.017
cardiac chamber development GO:0003205 108 0.017
regulation of mitotic cell cycle GO:0007346 126 0.017
lipid transport GO:0006869 98 0.017
purine nucleoside triphosphate catabolic process GO:0009146 203 0.017
organic acid transport GO:0015849 101 0.017
tor signaling GO:0031929 21 0.017
Fly
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 10 0.017
protein ubiquitination GO:0016567 171 0.017
regulation of map kinase activity GO:0043405 120 0.017
glial cell differentiation GO:0010001 131 0.017
skin development GO:0043588 220 0.017
regulation of growth hormone receptor signaling pathway GO:0060398 3 0.017
protein processing GO:0016485 163 0.017
negative regulation of neuron projection development GO:0010977 50 0.017
endocytosis GO:0006897 168 0.017
leukocyte mediated immunity GO:0002443 174 0.017
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:2001267 4 0.017
regulation of phospholipase c activity GO:1900274 3 0.016
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 6 0.016
cell division GO:0051301 120 0.016
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.016
regulation of nucleoside metabolic process GO:0009118 130 0.016
developmental growth involved in morphogenesis GO:0060560 138 0.016
posttranscriptional regulation of gene expression GO:0010608 155 0.016
jak stat cascade involved in growth hormone signaling pathway GO:0060397 4 0.016
interleukin 12 production GO:0032615 32 0.016
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.016
negative regulation of cell adhesion GO:0007162 45 0.016
positive regulation of calcium ion transport GO:0051928 27 0.016
defense response to other organism GO:0098542 197 0.016
appendage development GO:0048736 166 0.016
regulation of establishment of protein localization GO:0070201 181 0.016
engulfment of apoptotic cell GO:0043652 3 0.016
response to insulin GO:0032868 100 0.016
Mouse Fly
morphogenesis of a branching structure GO:0001763 203 0.016
positive regulation of binding GO:0051099 49 0.016
multi multicellular organism process GO:0044706 109 0.016
Fly
sensory organ morphogenesis GO:0090596 242 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
embryonic placenta development GO:0001892 98 0.016
regulation of cell shape GO:0008360 39 0.016
muscle system process GO:0003012 141 0.016
multicellular organismal homeostasis GO:0048871 164 0.016
negative regulation of synapse assembly GO:0051964 3 0.016
leukocyte homeostasis GO:0001776 79 0.016
Mouse
positive regulation of secretion by cell GO:1903532 114 0.016
ribonucleoside triphosphate catabolic process GO:0009203 199 0.015
purine ribonucleoside catabolic process GO:0046130 205 0.015
response to endoplasmic reticulum stress GO:0034976 53 0.015
negative regulation of alpha beta t cell activation GO:0046636 18 0.015
sequestering of metal ion GO:0051238 19 0.015
regulation of wnt signaling pathway GO:0030111 123 0.015
long term memory GO:0007616 15 0.015
retina morphogenesis in camera type eye GO:0060042 45 0.015
regulation of adaptive immune response GO:0002819 90 0.015
negative regulation of dna binding GO:0043392 20 0.015
mesenchyme development GO:0060485 152 0.015
proteasomal protein catabolic process GO:0010498 98 0.015
pallium development GO:0021543 120 0.015
detection of stimulus GO:0051606 84 0.015
negative regulation of phosphate metabolic process GO:0045936 184 0.015
phospholipid metabolic process GO:0006644 87 0.015
positive regulation of secretion GO:0051047 130 0.015
regulation of organelle organization GO:0033043 289 0.015
cerebral cortex cell migration GO:0021795 44 0.015
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.015
regulation of cytokine production involved in immune response GO:0002718 26 0.015
regulation of heart contraction GO:0008016 77 0.015
regulation of protein serine threonine kinase activity GO:0071900 157 0.015
regulation of blood circulation GO:1903522 93 0.015
regulation of cellular component size GO:0032535 121 0.015
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.015
fasl biosynthetic process GO:0045210 2 0.015
morphogenesis of embryonic epithelium GO:0016331 159 0.015
regulation of cell cycle GO:0051726 281 0.015
leukocyte apoptotic process GO:0071887 71 0.015
organelle localization GO:0051640 179 0.015
regulation of myeloid leukocyte differentiation GO:0002761 58 0.014
telencephalon cell migration GO:0022029 55 0.014
tissue migration GO:0090130 68 0.014
dendritic cell apoptotic process GO:0097048 3 0.014
meiotic nuclear division GO:0007126 115 0.014
glucose homeostasis GO:0042593 128 0.014
embryonic organ morphogenesis GO:0048562 276 0.014
negative regulation of binding GO:0051100 39 0.014
cell migration involved in gastrulation GO:0042074 13 0.014
inorganic ion transmembrane transport GO:0098660 234 0.014
single organismal cell cell adhesion GO:0016337 131 0.014
epithelial cell proliferation GO:0050673 174 0.014
positive regulation of jak stat cascade GO:0046427 22 0.014
regulation of dna binding GO:0051101 39 0.014
neuron death GO:0070997 154 0.014
establishment of organelle localization GO:0051656 122 0.014
aminoglycan biosynthetic process GO:0006023 15 0.014
membrane organization GO:0061024 245 0.014

Sh2b1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.050
cancer DOID:162 0 0.031
immune system disease DOID:2914 0 0.025
disease of anatomical entity DOID:7 0 0.025
hematopoietic system disease DOID:74 0 0.023
nervous system disease DOID:863 0 0.022
bone marrow disease DOID:4961 0 0.016
organ system cancer DOID:0050686 0 0.015