Mus musculus

87 known processes

Keap1

kelch-like ECH-associated protein 1

(Aliases: mKIAA0132,INRF2)

Keap1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 207 0.164
macromolecule catabolic process GO:0009057 281 0.141
regulation of cellular amine metabolic process GO:0033238 20 0.127
protein modification by small protein conjugation GO:0032446 187 0.118
protein catabolic process GO:0030163 221 0.112
regulation of cellular amino acid metabolic process GO:0006521 5 0.089
positive regulation of macroautophagy GO:0016239 3 0.088
cellular amino acid metabolic process GO:0006520 103 0.080
cellular ketone metabolic process GO:0042180 84 0.075
macroautophagy GO:0016236 21 0.074
modification dependent macromolecule catabolic process GO:0043632 133 0.074
membrane organization GO:0061024 245 0.072
peptidyl amino acid modification GO:0018193 336 0.067
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.066
protein processing GO:0016485 163 0.066
male gamete generation GO:0048232 285 0.066
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.065
modification dependent protein catabolic process GO:0019941 133 0.060
protein ubiquitination GO:0016567 171 0.060
cellular amine metabolic process GO:0044106 44 0.056
positive regulation of cellular amine metabolic process GO:0033240 5 0.055
chromatin modification GO:0016568 187 0.054
cellular homeostasis GO:0019725 240 0.051
i kappab kinase nf kappab signaling GO:0007249 85 0.050
chromatin organization GO:0006325 206 0.050
protein maturation GO:0051604 176 0.050
amine metabolic process GO:0009308 45 0.049
spermatogenesis GO:0007283 284 0.047
Mouse
response to nutrient levels GO:0031667 109 0.046
regulation of organelle organization GO:0033043 289 0.046
cytokine production GO:0001816 319 0.045
actin cytoskeleton organization GO:0030036 220 0.044
regulation of cellular response to stress GO:0080135 159 0.044
regulation of macroautophagy GO:0016241 12 0.043
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.042
negative regulation of cellular amine metabolic process GO:0033239 1 0.042
negative regulation of cellular protein metabolic process GO:0032269 247 0.041
cellular response to starvation GO:0009267 57 0.041
positive regulation of autophagy GO:0010508 9 0.041
negative regulation of protein modification process GO:0031400 163 0.041
metencephalon development GO:0022037 89 0.039
Mouse
cellular response to nutrient levels GO:0031669 64 0.038
regulation of cellular ketone metabolic process GO:0010565 66 0.038
positive regulation of protein modification process GO:0031401 299 0.038
establishment of protein localization to organelle GO:0072594 118 0.037
negative regulation of cellular component organization GO:0051129 194 0.037
cellular macromolecule catabolic process GO:0044265 206 0.036
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.036
immune effector process GO:0002252 321 0.036
intracellular protein transport GO:0006886 204 0.034
gland development GO:0048732 330 0.034
cellular protein catabolic process GO:0044257 155 0.034
cellular response to lipid GO:0071396 145 0.034
response to extracellular stimulus GO:0009991 127 0.033
microtubule based process GO:0007017 236 0.033
protein oligomerization GO:0051259 67 0.032
cellular response to cytokine stimulus GO:0071345 189 0.032
protein heterooligomerization GO:0051291 14 0.031
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.031
cellular lipid metabolic process GO:0044255 323 0.030
positive regulation of cellular catabolic process GO:0031331 148 0.030
cytoplasmic transport GO:0016482 234 0.030
protein acylation GO:0043543 64 0.030
histone modification GO:0016570 159 0.029
spermatid development GO:0007286 108 0.029
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.029
mitotic cell cycle GO:0000278 195 0.029
cellular response to extracellular stimulus GO:0031668 81 0.029
skeletal system development GO:0001501 356 0.029
purine ribonucleotide metabolic process GO:0009150 290 0.029
regulation of cell cycle GO:0051726 281 0.028
oocyte axis specification GO:0007309 2 0.028
locomotory behavior GO:0007626 195 0.028
Mouse
regulation of kinase activity GO:0043549 249 0.026
cellular response to external stimulus GO:0071496 88 0.026
apoptotic signaling pathway GO:0097190 306 0.026
Mouse
response to starvation GO:0042594 65 0.025
organic cyclic compound catabolic process GO:1901361 295 0.025
spermatid differentiation GO:0048515 115 0.025
Mouse
cell type specific apoptotic process GO:0097285 268 0.025
digestive system development GO:0055123 200 0.024
proteasomal protein catabolic process GO:0010498 98 0.024
immune response regulating signaling pathway GO:0002764 125 0.024
innate immune response GO:0045087 157 0.024
defense response to virus GO:0051607 68 0.024
regulation of cellular catabolic process GO:0031329 242 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.024
positive regulation of cell development GO:0010720 237 0.024
regulation of body fluid levels GO:0050878 162 0.023
homeostasis of number of cells GO:0048872 210 0.023
Mouse
endomembrane system organization GO:0010256 147 0.023
nucleobase containing small molecule metabolic process GO:0055086 352 0.023
negative regulation of phosphorus metabolic process GO:0010563 184 0.023
positive regulation of proteolysis GO:0045862 85 0.023
oxidation reduction process GO:0055114 342 0.023
heterocycle catabolic process GO:0046700 280 0.023
ubiquitin dependent protein catabolic process GO:0006511 129 0.023
organophosphate catabolic process GO:0046434 232 0.022
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
mapk cascade GO:0000165 281 0.022
myeloid cell homeostasis GO:0002262 114 0.022
sensory perception GO:0007600 245 0.022
protein localization to organelle GO:0033365 185 0.022
cellular response to organonitrogen compound GO:0071417 145 0.022
adult behavior GO:0030534 135 0.022
Mouse
positive regulation of organelle organization GO:0010638 128 0.022
cation transport GO:0006812 399 0.022
regulation of chromosome organization GO:0033044 83 0.021
carbohydrate derivative catabolic process GO:1901136 231 0.021
cellular nitrogen compound catabolic process GO:0044270 280 0.021
microtubule cytoskeleton organization GO:0000226 157 0.021
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.021
protein glycosylation GO:0006486 55 0.021
synaptic transmission GO:0007268 329 0.021
immune response activating signal transduction GO:0002757 116 0.021
carbohydrate metabolic process GO:0005975 230 0.021
activation of immune response GO:0002253 138 0.020
interspecies interaction between organisms GO:0044419 83 0.020
regulation of protein catabolic process GO:0042176 108 0.020
nucleotide catabolic process GO:0009166 217 0.020
negative regulation of molecular function GO:0044092 258 0.020
nucleoside phosphate catabolic process GO:1901292 222 0.020
metal ion homeostasis GO:0055065 189 0.020
transmembrane transport GO:0055085 412 0.020
viral process GO:0016032 41 0.020
negative regulation of protein phosphorylation GO:0001933 126 0.019
regulation of multi organism process GO:0043900 111 0.019
muscle tissue development GO:0060537 308 0.019
small gtpase mediated signal transduction GO:0007264 97 0.019
response to endoplasmic reticulum stress GO:0034976 53 0.019
t cell activation GO:0042110 289 0.019
response to lipopolysaccharide GO:0032496 128 0.019
regulation of proteolysis GO:0030162 164 0.019
ribose phosphate metabolic process GO:0019693 291 0.019
regulation of ossification GO:0030278 112 0.019
nitrogen compound transport GO:0071705 271 0.019
positive regulation of nervous system development GO:0051962 221 0.019
regulation of transferase activity GO:0051338 263 0.019
response to inorganic substance GO:0010035 96 0.019
response to organic cyclic compound GO:0014070 198 0.019
wound healing GO:0042060 157 0.019
protein targeting GO:0006605 143 0.018
aromatic compound catabolic process GO:0019439 286 0.018
muscle cell differentiation GO:0042692 261 0.018
protein import GO:0017038 101 0.018
regulation of defense response GO:0031347 233 0.018
purine nucleotide metabolic process GO:0006163 302 0.018
purine ribonucleoside metabolic process GO:0046128 241 0.018
regionalization GO:0003002 337 0.018
ras protein signal transduction GO:0007265 77 0.018
posttranscriptional regulation of gene expression GO:0010608 155 0.018
mitochondrion organization GO:0007005 134 0.018
negative regulation of protein maturation GO:1903318 79 0.017
purine nucleoside triphosphate catabolic process GO:0009146 203 0.017
striated muscle tissue development GO:0014706 293 0.017
cellular chemical homeostasis GO:0055082 215 0.017
ossification GO:0001503 216 0.017
covalent chromatin modification GO:0016569 163 0.017
peptidyl lysine modification GO:0018205 77 0.017
development of primary sexual characteristics GO:0045137 143 0.017
Mouse
divalent inorganic cation transport GO:0072511 178 0.016
placenta development GO:0001890 140 0.016
epithelial cell proliferation GO:0050673 174 0.016
dephosphorylation GO:0016311 129 0.016
positive regulation of protein catabolic process GO:0045732 60 0.016
maintenance of location GO:0051235 89 0.016
cellular response to molecule of bacterial origin GO:0071219 83 0.016
ribonucleoside metabolic process GO:0009119 245 0.016
single organism nuclear import GO:1902593 95 0.016
regulation of cellular component biogenesis GO:0044087 181 0.016
regulation of endopeptidase activity GO:0052548 89 0.016
cellular response to cadmium ion GO:0071276 3 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.016
cellular ion homeostasis GO:0006873 165 0.016
regulation of protein maturation GO:1903317 96 0.016
autophagy GO:0006914 45 0.016
alcohol metabolic process GO:0006066 116 0.016
regulation of cytokine production GO:0001817 266 0.016
regulation of anatomical structure size GO:0090066 178 0.016
peptidyl tyrosine modification GO:0018212 145 0.016
regulation of cell activation GO:0050865 289 0.016
intrinsic apoptotic signaling pathway GO:0097193 132 0.016
Mouse
regulation of ion transport GO:0043269 215 0.016
positive regulation of cell death GO:0010942 224 0.016
positive regulation of kinase activity GO:0033674 155 0.016
negative regulation of ossification GO:0030279 49 0.016
cellular protein complex assembly GO:0043623 116 0.016
internal protein amino acid acetylation GO:0006475 42 0.015
telencephalon development GO:0021537 186 0.015
organelle fission GO:0048285 170 0.015
small molecule catabolic process GO:0044282 71 0.015
negative regulation of organelle organization GO:0010639 90 0.015
regulation of hormone levels GO:0010817 211 0.015
striated muscle cell development GO:0055002 125 0.015
glycosyl compound metabolic process GO:1901657 246 0.015
positive regulation of response to wounding GO:1903036 66 0.015
cerebellum development GO:0021549 77 0.015
Mouse
cell maturation GO:0048469 127 0.015
viral life cycle GO:0019058 36 0.015
translation GO:0006412 93 0.015
glycoprotein metabolic process GO:0009100 116 0.015
central nervous system neuron differentiation GO:0021953 162 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.015
digestive tract development GO:0048565 190 0.015
nucleoside catabolic process GO:0009164 206 0.015
germ cell development GO:0007281 185 0.015
Mouse
response to acid chemical GO:0001101 111 0.015
regulation of membrane potential GO:0042391 192 0.015
pole plasm assembly GO:0007315 2 0.015
defense response to other organism GO:0098542 197 0.015
response to granulocyte macrophage colony stimulating factor GO:0097012 3 0.015
negative regulation of protein processing GO:0010955 79 0.014
cellularization GO:0007349 1 0.014
forebrain development GO:0030900 302 0.014
protein localization to nucleus GO:0034504 121 0.014
nucleoside phosphate metabolic process GO:0006753 338 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
Mouse
purine nucleoside metabolic process GO:0042278 241 0.014
wnt signaling pathway GO:0016055 188 0.014
ribonucleotide metabolic process GO:0009259 291 0.014
hindbrain development GO:0030902 128 0.014
Mouse
axonogenesis GO:0007409 274 0.014
regulation of cell cycle process GO:0010564 160 0.014
response to peptide hormone GO:0043434 127 0.014
nucleotide metabolic process GO:0009117 332 0.014
regulation of chromatin organization GO:1902275 57 0.014
purine containing compound metabolic process GO:0072521 311 0.014
regulation of mapk cascade GO:0043408 248 0.014
negative regulation of proteolysis GO:0045861 74 0.013
divalent metal ion transport GO:0070838 172 0.013
cerebellar purkinje cell layer development GO:0021680 26 0.013
Mouse
sensory organ morphogenesis GO:0090596 242 0.013
organonitrogen compound catabolic process GO:1901565 264 0.013
compound eye development GO:0048749 1 0.013
cellular response to dna damage stimulus GO:0006974 207 0.013
regulation of secretion GO:0051046 274 0.013
regulation of cytoplasmic transport GO:1903649 112 0.013
regulation of stress activated mapk cascade GO:0032872 69 0.013
regulation of actin filament based process GO:0032970 99 0.013
stress activated mapk cascade GO:0051403 80 0.013
cytokine biosynthetic process GO:0042089 68 0.013
leukocyte differentiation GO:0002521 342 0.013
negative regulation of neuron death GO:1901215 98 0.013
cellular carbohydrate metabolic process GO:0044262 119 0.013
positive regulation of intracellular transport GO:0032388 70 0.013
cell adhesion GO:0007155 329 0.013
negative regulation of phosphorylation GO:0042326 166 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
intracellular mrna localization GO:0008298 4 0.013
regulation of autophagy GO:0010506 30 0.013
cellular response to organic cyclic compound GO:0071407 87 0.013
regulation of reactive oxygen species metabolic process GO:2000377 40 0.013
cerebellar cortex development GO:0021695 48 0.013
Mouse
response to oxygen levels GO:0070482 62 0.013
ion transmembrane transport GO:0034220 361 0.013
negative regulation of immune system process GO:0002683 209 0.013
dna metabolic process GO:0006259 303 0.012
positive regulation of transferase activity GO:0051347 167 0.012
response to organonitrogen compound GO:0010243 246 0.012
positive regulation of protein kinase activity GO:0045860 144 0.012
calcium ion transport GO:0006816 159 0.012
glycoprotein biosynthetic process GO:0009101 89 0.012
regulation of cell migration GO:0030334 219 0.012
cell junction maintenance GO:0034331 4 0.012
response to epidermal growth factor GO:0070849 4 0.012
cytokine mediated signaling pathway GO:0019221 115 0.012
organelle localization GO:0051640 179 0.012
regulation of cell growth GO:0001558 91 0.012
embryonic organ morphogenesis GO:0048562 276 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
regulation of translation GO:0006417 71 0.012
regulation of t cell activation GO:0050863 170 0.012
developmental maturation GO:0021700 193 0.012
regulation of cellular protein catabolic process GO:1903362 61 0.012
regulation of neuron differentiation GO:0045664 281 0.012
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.012
body fluid secretion GO:0007589 53 0.012
anion transport GO:0006820 177 0.012
ribonucleoside catabolic process GO:0042454 206 0.012
regulation of lymphocyte activation GO:0051249 240 0.012
oocyte anterior posterior axis specification GO:0007314 2 0.012
amide transport GO:0042886 138 0.012
gastrulation GO:0007369 116 0.012
cartilage development GO:0051216 140 0.012
positive regulation of cell cycle GO:0045787 92 0.012
regulation of system process GO:0044057 200 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
b cell activation GO:0042113 161 0.012
meiosis i GO:0007127 60 0.011
meiotic nuclear division GO:0007126 115 0.011
epidermis development GO:0008544 187 0.011
regulation of homeostatic process GO:0032844 182 0.011
nucleoside metabolic process GO:0009116 246 0.011
glial cell differentiation GO:0010001 131 0.011
response to peptide GO:1901652 136 0.011
regulation of chromatin modification GO:1903308 57 0.011
connective tissue development GO:0061448 179 0.011
localization within membrane GO:0051668 4 0.011
regulation of neuron death GO:1901214 134 0.011
fatty acid metabolic process GO:0006631 121 0.011
asymmetric stem cell division GO:0098722 3 0.011
multicellular organismal signaling GO:0035637 91 0.011
positive regulation of cell activation GO:0050867 158 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
muscle system process GO:0003012 141 0.011
lymphocyte differentiation GO:0030098 242 0.011
stem cell differentiation GO:0048863 268 0.011
regulation of response to biotic stimulus GO:0002831 38 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
nuclear transport GO:0051169 139 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
cellular response to granulocyte macrophage colony stimulating factor stimulus GO:0097011 3 0.011
regulation of hydrolase activity GO:0051336 246 0.011
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.011
response to amino acid GO:0043200 37 0.011
ribonucleoside triphosphate catabolic process GO:0009203 199 0.010
regulation of cell motility GO:2000145 236 0.010
protein polymerization GO:0051258 57 0.010
leukocyte proliferation GO:0070661 172 0.010
adult locomotory behavior GO:0008344 91 0.010
Mouse
nuclear division GO:0000280 158 0.010
activation of cysteine type endopeptidase activity GO:0097202 27 0.010
circulatory system process GO:0003013 197 0.010
retrograde transport endosome to golgi GO:0042147 2 0.010
neuron death GO:0070997 154 0.010
cell division GO:0051301 120 0.010
pharynx development GO:0060465 1 0.010
carbohydrate homeostasis GO:0033500 128 0.010
lymphocyte proliferation GO:0046651 164 0.010
negative regulation of transferase activity GO:0051348 85 0.010
regulation of blood pressure GO:0008217 93 0.010
gonad development GO:0008406 141 0.010
Mouse
ribonucleotide catabolic process GO:0009261 208 0.010
peptidyl lysine acetylation GO:0018394 45 0.010
monocarboxylic acid metabolic process GO:0032787 191 0.010

Keap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.322
musculoskeletal system disease DOID:17 0 0.322
connective tissue disease DOID:65 0 0.322
bone disease DOID:0080001 0 0.074
bone remodeling disease DOID:0080005 0 0.073
nervous system disease DOID:863 0 0.031
muscular disease DOID:0080000 0 0.027
muscle tissue disease DOID:66 0 0.022
central nervous system disease DOID:331 0 0.021
disease of metabolism DOID:0014667 0 0.017
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.012
sensory system disease DOID:0050155 0 0.012
neurodegenerative disease DOID:1289 0 0.010
organ system cancer DOID:0050686 0 0.010