Mus musculus

68 known processes

Sim1

single-minded homolog 1 (Drosophila)

(Aliases: mSIM1,bHLHe14)

Sim1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
forebrain development GO:0030900 302 0.979
Zebrafish Mouse
endocrine system development GO:0035270 98 0.896
hypothalamus cell differentiation GO:0021979 8 0.883
Zebrafish
forebrain neuron differentiation GO:0021879 52 0.825
columnar cuboidal epithelial cell development GO:0002066 29 0.812
Mouse
response to peptide hormone GO:0043434 127 0.795
peptide transport GO:0015833 133 0.769
Mouse
forebrain generation of neurons GO:0021872 63 0.759
telencephalon development GO:0021537 186 0.743
Mouse
chemotaxis GO:0006935 247 0.707
Zebrafish Fly
cellular response to peptide GO:1901653 92 0.704
gliogenesis GO:0042063 141 0.700
multicellular organism growth GO:0035264 161 0.679
hindbrain development GO:0030902 128 0.676
cellular response to peptide hormone stimulus GO:0071375 92 0.636
central nervous system neuron differentiation GO:0021953 162 0.634
diencephalon development GO:0021536 63 0.616
Zebrafish
limbic system development GO:0021761 72 0.613
Zebrafish
muscle cell differentiation GO:0042692 261 0.592
Mouse
axonogenesis GO:0007409 274 0.586
Zebrafish Fly
neuroblast proliferation GO:0007405 49 0.577
Mouse
stem cell differentiation GO:0048863 268 0.565
Mouse
epithelial cell development GO:0002064 159 0.551
Mouse
columnar cuboidal epithelial cell maturation GO:0002069 4 0.539
Mouse
neuron projection guidance GO:0097485 141 0.535
Zebrafish Fly
pallium development GO:0021543 120 0.527
Mouse
embryonic organ morphogenesis GO:0048562 276 0.522
Mouse
positive regulation of nervous system development GO:0051962 221 0.518
Mouse
neuron fate specification GO:0048665 30 0.513
insulin secretion GO:0030073 89 0.509
Mouse
skin development GO:0043588 220 0.497
angiogenesis GO:0001525 201 0.492
Mouse
developmental maturation GO:0021700 193 0.492
Mouse
cerebral cortex development GO:0021987 86 0.491
Mouse
hypothalamus development GO:0021854 16 0.491
Zebrafish
gland development GO:0048732 330 0.489
Mouse
sensory organ morphogenesis GO:0090596 242 0.487
cell fate specification GO:0001708 72 0.480
metal ion homeostasis GO:0055065 189 0.478
Mouse
embryonic placenta development GO:0001892 98 0.472
Mouse
neural precursor cell proliferation GO:0061351 121 0.462
Mouse
positive regulation of cell development GO:0010720 237 0.459
Mouse
stem cell development GO:0048864 219 0.458
Mouse
regulation of wnt signaling pathway GO:0030111 123 0.454
negative regulation of neuron death GO:1901215 98 0.452
Mouse
inorganic anion transport GO:0015698 43 0.443
cellular response to hormone stimulus GO:0032870 150 0.440
glandular epithelial cell differentiation GO:0002067 38 0.437
axon guidance GO:0007411 141 0.437
Zebrafish Fly
pancreas development GO:0031016 57 0.437
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.430
cell fate commitment GO:0045165 210 0.421
Mouse Fly
nephron tubule development GO:0072080 84 0.419
cell adhesion GO:0007155 329 0.417
response to insulin GO:0032868 100 0.412
response to organonitrogen compound GO:0010243 246 0.411
retina development in camera type eye GO:0060041 119 0.406
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.390
Mouse
response to growth factor GO:0070848 198 0.388
Mouse
glycolytic process GO:0006096 20 0.387
Mouse
response to peptide GO:1901652 136 0.385
cerebral cortex radially oriented cell migration GO:0021799 31 0.380
spinal cord development GO:0021510 81 0.372
carbohydrate homeostasis GO:0033500 128 0.372
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.371
nuclear transport GO:0051169 139 0.363
mesonephric tubule development GO:0072164 94 0.355
tube formation GO:0035148 140 0.354
Mouse
regulation of hormone levels GO:0010817 211 0.353
Mouse
outflow tract morphogenesis GO:0003151 53 0.353
Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.353
anion transport GO:0006820 177 0.353
skeletal system morphogenesis GO:0048705 203 0.352
neurohypophysis development GO:0021985 2 0.350
second messenger mediated signaling GO:0019932 73 0.346
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.342
Mouse
intestinal epithelial cell maturation GO:0060574 2 0.340
Mouse
regulation of carbohydrate metabolic process GO:0006109 75 0.339
Mouse
regulation of cell migration GO:0030334 219 0.332
Mouse
epithelial tube morphogenesis GO:0060562 303 0.324
Mouse
hormone secretion GO:0046879 128 0.324
Mouse
skeletal muscle cell differentiation GO:0035914 66 0.324
leukocyte differentiation GO:0002521 342 0.322
cellular response to organonitrogen compound GO:0071417 145 0.320
cellular amino acid metabolic process GO:0006520 103 0.315
spermatogenesis GO:0007283 284 0.311
cell proliferation in hindbrain GO:0021534 10 0.310
negative regulation of intracellular signal transduction GO:1902532 167 0.309
Mouse
eye photoreceptor cell differentiation GO:0001754 41 0.305
forebrain cell migration GO:0021885 58 0.305
purine nucleotide biosynthetic process GO:0006164 65 0.303
kidney development GO:0001822 213 0.302
regulation of canonical wnt signaling pathway GO:0060828 82 0.302
cell differentiation in spinal cord GO:0021515 53 0.302
central nervous system neuron development GO:0021954 67 0.302
modification dependent protein catabolic process GO:0019941 133 0.297
male gamete generation GO:0048232 285 0.295
cardiac ventricle morphogenesis GO:0003208 50 0.295
Mouse
endocrine pancreas development GO:0031018 29 0.278
regulation of tor signaling GO:0032006 17 0.278
Mouse
heart morphogenesis GO:0003007 178 0.277
Mouse
determination of left right symmetry GO:0007368 80 0.276
Mouse
forebrain neuron fate commitment GO:0021877 13 0.276
regulation of cell motility GO:2000145 236 0.269
Mouse
urogenital system development GO:0001655 261 0.268
canonical wnt signaling pathway GO:0060070 130 0.266
blood vessel morphogenesis GO:0048514 285 0.266
Mouse
regulation of organ morphogenesis GO:2000027 144 0.264
trachea cartilage morphogenesis GO:0060535 4 0.262
epidermis development GO:0008544 187 0.262
cellular amine metabolic process GO:0044106 44 0.262
spinal cord association neuron differentiation GO:0021527 14 0.262
cellular ion homeostasis GO:0006873 165 0.260
Mouse
granulocyte colony stimulating factor production GO:0071611 1 0.258
embryonic epithelial tube formation GO:0001838 130 0.256
Mouse
regulation of neuron differentiation GO:0045664 281 0.252
protein modification by small protein conjugation GO:0032446 187 0.252
cellular response to oxidative stress GO:0034599 76 0.251
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.251
cellular carbohydrate metabolic process GO:0044262 119 0.246
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.239
response to oxygen levels GO:0070482 62 0.238
Mouse
renal tubule development GO:0061326 87 0.236
regulation of carbohydrate biosynthetic process GO:0043255 40 0.235
glial cell differentiation GO:0010001 131 0.234
protein localization to nucleus GO:0034504 121 0.234
development of primary male sexual characteristics GO:0046546 88 0.230
response to acid chemical GO:0001101 111 0.229
lung cell differentiation GO:0060479 30 0.228
regulation of peptide hormone secretion GO:0090276 75 0.226
Mouse
spinal cord motor neuron differentiation GO:0021522 35 0.225
dorsal spinal cord development GO:0021516 20 0.224
neural crest cell development GO:0014032 48 0.222
Mouse
neuron death GO:0070997 154 0.221
Mouse
developmental cell growth GO:0048588 84 0.220
neuron apoptotic process GO:0051402 142 0.220
Mouse
forebrain neuron development GO:0021884 30 0.216
morphogenesis of a branching epithelium GO:0061138 193 0.215
neural fold elevation formation GO:0021502 1 0.214
Mouse
stem cell division GO:0017145 30 0.213
nucleotide metabolic process GO:0009117 332 0.212
muscle tissue development GO:0060537 308 0.207
metanephric loop of henle development GO:0072236 4 0.206
regulation of blood circulation GO:1903522 93 0.206
Mouse
response to oxidative stress GO:0006979 123 0.203
Mouse
neural tube formation GO:0001841 108 0.203
Mouse
rhythmic process GO:0048511 174 0.202
nitrogen compound transport GO:0071705 271 0.202
Mouse
establishment of protein localization to organelle GO:0072594 118 0.200
regulation of myeloid cell differentiation GO:0045637 96 0.199
Mouse
digestive tract development GO:0048565 190 0.199
Mouse
regulation of ion transport GO:0043269 215 0.199
lung development GO:0030324 164 0.199
Mouse
protein import GO:0017038 101 0.198
mesenchymal cell development GO:0014031 93 0.198
Mouse
respiratory system development GO:0060541 190 0.197
Mouse
negative regulation of neuron apoptotic process GO:0043524 92 0.197
Mouse
divalent inorganic cation homeostasis GO:0072507 138 0.197
renal system development GO:0072001 225 0.197
motor neuron migration GO:0097475 4 0.196
morphogenesis of embryonic epithelium GO:0016331 159 0.196
Mouse
regionalization GO:0003002 337 0.196
organic hydroxy compound transport GO:0015850 93 0.194
ectoderm formation GO:0001705 3 0.194
hair cell differentiation GO:0035315 40 0.192
lateral motor column neuron migration GO:0097477 3 0.191
organophosphate biosynthetic process GO:0090407 122 0.190
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.189
response to monosaccharide GO:0034284 67 0.189
Mouse
ureteric bud development GO:0001657 94 0.189
intraspecies interaction between organisms GO:0051703 21 0.189
glucose homeostasis GO:0042593 128 0.188
Mouse
inner ear morphogenesis GO:0042472 101 0.185
mammary gland lobule development GO:0061377 22 0.182
Mouse
subpallium neuron fate commitment GO:0060163 2 0.182
neural tube development GO:0021915 160 0.176
Mouse
cerebral cortex cell migration GO:0021795 44 0.175
b cell activation GO:0042113 161 0.175
regulation of secretion by cell GO:1903530 249 0.175
Mouse
dendrite development GO:0016358 115 0.175
amine metabolic process GO:0009308 45 0.174
telencephalon cell migration GO:0022029 55 0.173
peripheral nervous system neuron axonogenesis GO:0048936 3 0.173
potassium ion transport GO:0006813 52 0.172
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.171
cell maturation GO:0048469 127 0.171
Mouse
kidney epithelium development GO:0072073 121 0.170
modification dependent macromolecule catabolic process GO:0043632 133 0.169
striated muscle tissue development GO:0014706 293 0.169
olfactory bulb development GO:0021772 30 0.168
mechanoreceptor differentiation GO:0042490 67 0.167
positive regulation of mesonephros development GO:0061213 20 0.167
type b pancreatic cell differentiation GO:0003309 13 0.166
cation homeostasis GO:0055080 212 0.166
Mouse
cellular ketone metabolic process GO:0042180 84 0.166
placenta development GO:0001890 140 0.165
Mouse
response to nutrient levels GO:0031667 109 0.165
positive regulation of growth GO:0045927 104 0.164
cranial nerve development GO:0021545 41 0.163
digestive system development GO:0055123 200 0.161
Mouse
ubiquitin dependent protein catabolic process GO:0006511 129 0.161
regulation of cellular response to stress GO:0080135 159 0.159
carbohydrate transport GO:0008643 62 0.157
wnt signaling pathway GO:0016055 188 0.156
negative regulation of fat cell differentiation GO:0045599 36 0.156
nephron development GO:0072006 109 0.156
somatotropin secreting cell differentiation GO:0060126 4 0.155
positive regulation of skeletal muscle cell differentiation GO:2001016 4 0.154
ear morphogenesis GO:0042471 118 0.154
negative regulation of wnt signaling pathway GO:0030178 73 0.154
mesoderm development GO:0007498 100 0.154
fat cell differentiation GO:0045444 160 0.151
positive regulation of protein modification process GO:0031401 299 0.151
regulation of carbohydrate catabolic process GO:0043470 12 0.150
Mouse
tube closure GO:0060606 91 0.150
embryonic skeletal system development GO:0048706 120 0.150
regulation of organ formation GO:0003156 34 0.150
regulation of peptide secretion GO:0002791 77 0.149
Mouse
mesenchyme development GO:0060485 152 0.148
Mouse
formation of primary germ layer GO:0001704 77 0.147
inner ear receptor cell differentiation GO:0060113 61 0.145
metanephric dct cell differentiation GO:0072240 3 0.144
phenol containing compound metabolic process GO:0018958 60 0.143
Mouse
camera type eye development GO:0043010 266 0.143
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.142
protein import into nucleus translocation GO:0000060 12 0.142
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.142
lung epithelial cell differentiation GO:0060487 29 0.141
enteroendocrine cell differentiation GO:0035883 16 0.140
cell growth GO:0016049 130 0.139
neural crest cell migration GO:0001755 32 0.139
Mouse
epithelial tube formation GO:0072175 130 0.138
Mouse
aortic valve morphogenesis GO:0003180 4 0.138
cell proliferation in forebrain GO:0021846 30 0.138
negative regulation of nervous system development GO:0051961 156 0.136
nucleoside phosphate metabolic process GO:0006753 338 0.136
response to extracellular stimulus GO:0009991 127 0.135
cellular response to insulin stimulus GO:0032869 78 0.134
trophectodermal cell differentiation GO:0001829 21 0.133
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.133
nephron epithelium development GO:0072009 92 0.133
inorganic ion transmembrane transport GO:0098660 234 0.132
neuron migration GO:0001764 122 0.132
purine ribonucleotide biosynthetic process GO:0009152 59 0.132
stem cell maintenance GO:0019827 130 0.132
visceral motor neuron differentiation GO:0021524 3 0.130
peptidyl amino acid modification GO:0018193 336 0.130
lymphocyte differentiation GO:0030098 242 0.129
negative regulation of molecular function GO:0044092 258 0.128
morphogenesis of a branching structure GO:0001763 203 0.127
cell type specific apoptotic process GO:0097285 268 0.127
Mouse
cellular macromolecule catabolic process GO:0044265 206 0.126
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.126
b cell differentiation GO:0030183 78 0.126
negative regulation of tor signaling GO:0032007 13 0.125
Mouse
spleen development GO:0048536 39 0.124
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.123
dopaminergic neuron differentiation GO:0071542 14 0.123
Zebrafish Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.122
glucose import GO:0046323 32 0.122
transdifferentiation GO:0060290 1 0.122
cellular glucose homeostasis GO:0001678 52 0.121
Mouse
cell division GO:0051301 120 0.121
mesoderm formation GO:0001707 62 0.121
development of primary sexual characteristics GO:0045137 143 0.121
astrocyte fate commitment GO:0060018 4 0.120
olfactory lobe development GO:0021988 32 0.118
cellular chemical homeostasis GO:0055082 215 0.118
Mouse
kidney morphogenesis GO:0060993 83 0.118
regulation of glucose metabolic process GO:0010906 60 0.118
ear development GO:0043583 200 0.118
monosaccharide metabolic process GO:0005996 106 0.117
hormone metabolic process GO:0042445 86 0.117
regulation of neuron death GO:1901214 134 0.116
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.116
blastocyst development GO:0001824 80 0.116
cerebellar granule cell precursor proliferation GO:0021930 10 0.116
regulation of retina development in camera type eye GO:1902866 3 0.115
astrocyte differentiation GO:0048708 43 0.115
sensory system development GO:0048880 3 0.115
locomotory behavior GO:0007626 195 0.115
Mouse Fly
bmp signaling pathway GO:0030509 93 0.114
mesenchymal cell differentiation GO:0048762 107 0.114
Mouse
cardiac chamber development GO:0003205 108 0.113
Mouse
myeloid cell homeostasis GO:0002262 114 0.113
Mouse
nucleocytoplasmic transport GO:0006913 139 0.112
regulation of glycogen metabolic process GO:0070873 13 0.112
branching morphogenesis of an epithelial tube GO:0048754 159 0.111
ventricular system development GO:0021591 27 0.111
cardiac cell fate determination GO:0060913 2 0.109
stem cell proliferation GO:0072089 117 0.109
Mouse
negative regulation of canonical wnt signaling pathway GO:0090090 51 0.109
response to light stimulus GO:0009416 135 0.109
Mouse
regulation of secretion GO:0051046 274 0.109
Mouse
ribose phosphate biosynthetic process GO:0046390 59 0.108
motor neuron axon guidance GO:0008045 26 0.108
ribonucleotide metabolic process GO:0009259 291 0.107
semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:0071527 1 0.107
regulation of protein localization GO:0032880 231 0.107
ventral spinal cord interneuron fate commitment GO:0060579 14 0.107
regulation of cellular catabolic process GO:0031329 242 0.105
Mouse
regulation of stem cell proliferation GO:0072091 78 0.105
Mouse
oxidation reduction process GO:0055114 342 0.104
lymphocyte activation involved in immune response GO:0002285 93 0.104
blastocyst formation GO:0001825 33 0.104
positive regulation of secondary heart field cardioblast proliferation GO:0072513 4 0.104
carbohydrate biosynthetic process GO:0016051 74 0.103
brain segmentation GO:0035284 3 0.103
auditory receptor cell fate specification GO:0042667 1 0.103
regulation of transcription from rna polymerase ii promoter involved in ventral spinal cord interneuron specification GO:0021913 4 0.103
appendage morphogenesis GO:0035107 149 0.101
regulation of epithelial cell proliferation GO:0050678 141 0.101
pituitary gland development GO:0021983 38 0.101
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.100
regulation of cell cycle GO:0051726 281 0.100
pancreatic a cell fate commitment GO:0003326 2 0.100
respiratory tube development GO:0030323 167 0.099
Mouse
neuron maturation GO:0042551 29 0.099
neural crest cell differentiation GO:0014033 54 0.099
Mouse
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.098
spinal cord motor neuron cell fate specification GO:0021520 13 0.098
response to testosterone GO:0033574 3 0.098
positive regulation of peptide secretion GO:0002793 33 0.098
Mouse
ion transmembrane transport GO:0034220 361 0.097
protein import into nucleus GO:0006606 95 0.097
cognition GO:0050890 149 0.096
Mouse
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.096
limb development GO:0060173 166 0.096
asymmetric stem cell division GO:0098722 3 0.095
peripheral nervous system neuron development GO:0048935 9 0.095
somatotropin secreting cell development GO:0060133 2 0.095
cyclic purine nucleotide metabolic process GO:0052652 43 0.095
photoreceptor cell differentiation GO:0046530 52 0.093
cell cell signaling involved in cell fate commitment GO:0045168 35 0.093
autonomic nervous system development GO:0048483 43 0.093
positive regulation of stem cell proliferation GO:2000648 59 0.093
Mouse
regulation of neural retina development GO:0061074 3 0.093
mesenchymal cell apoptotic process GO:0097152 14 0.092
Mouse
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.092
body morphogenesis GO:0010171 45 0.091
regulation of protein transport GO:0051223 163 0.091
regulation of glycolytic process GO:0006110 10 0.090
Mouse
photoreceptor cell development GO:0042461 40 0.090
somitogenesis GO:0001756 69 0.090
protein localization to organelle GO:0033365 185 0.090
male sex determination GO:0030238 14 0.090
alpha beta t cell differentiation GO:0046632 69 0.090
ventral spinal cord development GO:0021517 48 0.090
cytoplasmic transport GO:0016482 234 0.089
regulation of nucleotide metabolic process GO:0006140 169 0.089
hindlimb morphogenesis GO:0035137 42 0.088
cell proliferation in external granule layer GO:0021924 10 0.087
nucleobase containing small molecule metabolic process GO:0055086 352 0.087
positive regulation of glycolytic process GO:0045821 4 0.086
positive regulation of programmed cell death GO:0043068 218 0.085
single organism cell adhesion GO:0098602 156 0.085
male sex differentiation GO:0046661 109 0.085
spinal cord motor neuron migration GO:0097476 4 0.085
positive regulation of cell cycle GO:0045787 92 0.085
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.084
positive regulation of neural precursor cell proliferation GO:2000179 42 0.084
Mouse
oviduct development GO:0060066 3 0.083
ventricular septum development GO:0003281 42 0.083
lung epithelium development GO:0060428 37 0.083
ribonucleotide biosynthetic process GO:0009260 59 0.083
nephron tubule morphogenesis GO:0072078 68 0.083
glial cell development GO:0021782 54 0.083
cation transport GO:0006812 399 0.082
regulation of auditory receptor cell differentiation GO:0045607 4 0.081
regulation of anatomical structure size GO:0090066 178 0.080
forelimb morphogenesis GO:0035136 40 0.080
apoptotic mitochondrial changes GO:0008637 48 0.079
calcium ion homeostasis GO:0055074 127 0.079
regulation of glucose transport GO:0010827 32 0.079
cell cell signaling involved in mammary gland development GO:0060764 2 0.079
response to organic cyclic compound GO:0014070 198 0.079
auditory receptor cell differentiation GO:0042491 37 0.079
epithelial cell proliferation GO:0050673 174 0.078
mammary gland duct morphogenesis GO:0060603 38 0.078
regulation of interleukin 1 alpha production GO:0032650 4 0.078
glucose metabolic process GO:0006006 92 0.078
response to steroid hormone GO:0048545 56 0.078
positive regulation of insulin secretion GO:0032024 26 0.078
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.078
muscle tissue morphogenesis GO:0060415 53 0.077
carbohydrate metabolic process GO:0005975 230 0.077
Mouse
thick ascending limb development GO:0072023 2 0.077
appendage development GO:0048736 166 0.077
cardiac chamber morphogenesis GO:0003206 93 0.076
Mouse
gabaergic neuron differentiation GO:0097154 11 0.076
cardiocyte differentiation GO:0035051 87 0.076
hindbrain morphogenesis GO:0021575 46 0.076
bronchiole development GO:0060435 3 0.076
specification of organ identity GO:0010092 30 0.075
tor signaling GO:0031929 21 0.075
Mouse
peptide secretion GO:0002790 114 0.075
Mouse
exocrine system development GO:0035272 45 0.075
mesoderm morphogenesis GO:0048332 64 0.075
peptide hormone secretion GO:0030072 109 0.075
Mouse
glossopharyngeal nerve morphogenesis GO:0021615 4 0.074
mitral valve development GO:0003174 4 0.074
glucose transport GO:0015758 56 0.073
regulation of fat cell differentiation GO:0045598 81 0.073
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.073
cytosolic calcium ion homeostasis GO:0051480 70 0.073
positive regulation of peptide hormone secretion GO:0090277 31 0.073
Mouse
positive regulation of epithelial cell differentiation involved in kidney development GO:2000698 2 0.072
regulation of generation of precursor metabolites and energy GO:0043467 38 0.072
Mouse
hippocampus development GO:0021766 52 0.072
negative regulation of secretion by cell GO:1903531 54 0.071
regulation of vasculature development GO:1901342 88 0.071
branching involved in ureteric bud morphogenesis GO:0001658 56 0.071
cellular response to starvation GO:0009267 57 0.070
hexose metabolic process GO:0019318 98 0.070
oligodendrocyte differentiation GO:0048709 53 0.070
auditory receptor cell fate determination GO:0042668 3 0.070
regulation of insulin receptor signaling pathway GO:0046626 21 0.070
response to decreased oxygen levels GO:0036293 59 0.070
Mouse
regulation of transporter activity GO:0032409 57 0.069
regulation of kinase activity GO:0043549 249 0.068
regulation of morphogenesis of a branching structure GO:0060688 53 0.068
tendon formation GO:0035992 4 0.067
methionine transport GO:0015821 1 0.067
cardiac ventricle development GO:0003231 83 0.067
Mouse
regulation of mapk cascade GO:0043408 248 0.067
glycogen metabolic process GO:0005977 32 0.067
positive regulation of cell migration GO:0030335 109 0.066
Mouse
syncytium formation by plasma membrane fusion GO:0000768 42 0.066
cerebral cortex neuron differentiation GO:0021895 19 0.066
response to transforming growth factor beta GO:0071559 88 0.065
glucose 6 phosphate metabolic process GO:0051156 8 0.065
cellular protein catabolic process GO:0044257 155 0.064
gonad development GO:0008406 141 0.064
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.064
positive regulation of cell motility GO:2000147 116 0.064
Mouse
negative regulation of neuron differentiation GO:0045665 101 0.064
retina morphogenesis in camera type eye GO:0060042 45 0.064
intracellular protein transport GO:0006886 204 0.064
regulation of neuron apoptotic process GO:0043523 122 0.063
Mouse
myeloid cell differentiation GO:0030099 233 0.063
Mouse
dct cell differentiation GO:0072069 3 0.063
organic anion transport GO:0015711 137 0.063
t cell differentiation GO:0030217 174 0.063
connective tissue development GO:0061448 179 0.063
Mouse
protein targeting GO:0006605 143 0.062
adult behavior GO:0030534 135 0.062
Fly
sclerotome development GO:0061056 4 0.062
multi organism behavior GO:0051705 62 0.062
Mouse
regulation of system process GO:0044057 200 0.062
Mouse
circadian regulation of gene expression GO:0032922 48 0.062
regulation of circadian rhythm GO:0042752 58 0.061
regulation of glucan biosynthetic process GO:0010962 7 0.061
positive regulation of muscle tissue development GO:1901863 32 0.061
neuron projection extension GO:1990138 64 0.061
peptidyl tyrosine modification GO:0018212 145 0.060
ventral spinal cord interneuron differentiation GO:0021514 16 0.060
paraxial mesodermal cell fate commitment GO:0048343 2 0.060
germ cell development GO:0007281 185 0.059
chondrocyte differentiation GO:0002062 72 0.059
proteasomal protein catabolic process GO:0010498 98 0.059
negative regulation of cell development GO:0010721 169 0.059
positive regulation of glial cell proliferation GO:0060252 4 0.058
neuroblast differentiation GO:0014016 2 0.058
positive regulation of wnt signaling pathway GO:0030177 45 0.058
renal tubule morphogenesis GO:0061333 72 0.057
associative learning GO:0008306 61 0.057
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.057
regulation of purine nucleotide metabolic process GO:1900542 169 0.056
respiratory system process GO:0003016 25 0.056
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.056
peripheral nervous system development GO:0007422 53 0.056
monosaccharide transport GO:0015749 58 0.056
regulation of erythrocyte differentiation GO:0045646 23 0.056
Mouse
digestive tract morphogenesis GO:0048546 147 0.056
Mouse
neural tube closure GO:0001843 90 0.055
regulation of embryonic development GO:0045995 71 0.055
regulation of cellular component biogenesis GO:0044087 181 0.055
hexose transport GO:0008645 56 0.055
regulation of cellular amine metabolic process GO:0033238 20 0.055
female sex differentiation GO:0046660 84 0.055
negative regulation of gluconeogenesis GO:0045721 9 0.055
leukocyte proliferation GO:0070661 172 0.055
pancreatic pp cell fate commitment GO:0003329 2 0.054
regulation of cardiac chamber morphogenesis GO:1901219 2 0.054
negative regulation of phosphorylation GO:0042326 166 0.054
lateral inhibition GO:0046331 1 0.054
ectodermal placode formation GO:0060788 16 0.054

Sim1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.473
Human
diabetes mellitus DOID:9351 0 0.275
type 2 diabetes mellitus DOID:9352 0 0.275
carbohydrate metabolism disease DOID:0050013 0 0.275
glucose metabolism disease DOID:4194 0 0.275
acquired metabolic disease DOID:0060158 0 0.275
Human
carbohydrate metabolic disorder DOID:2978 0 0.223
inherited metabolic disorder DOID:655 0 0.223
disease of cellular proliferation DOID:14566 0 0.057