Mus musculus

74 known processes

Siah1a

seven in absentia 1A

(Aliases: Sinh1a,AA982064,AI853500)

Siah1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
male gamete generation GO:0048232 285 0.476
spermatogenesis GO:0007283 284 0.320
spermatid differentiation GO:0048515 115 0.292
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.236
negative regulation of protein metabolic process GO:0051248 282 0.232
spermatid development GO:0007286 108 0.220
modification dependent protein catabolic process GO:0019941 133 0.178
protein catabolic process GO:0030163 221 0.171
oocyte axis specification GO:0007309 2 0.171
negative regulation of cellular protein metabolic process GO:0032269 247 0.171
protein ubiquitination GO:0016567 171 0.149
regionalization GO:0003002 337 0.145
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.138
protein modification by small protein conjugation GO:0032446 187 0.128
oocyte construction GO:0007308 2 0.126
protein modification by small protein conjugation or removal GO:0070647 207 0.124
cellular protein catabolic process GO:0044257 155 0.120
germ cell development GO:0007281 185 0.116
pole plasm assembly GO:0007315 2 0.112
modification dependent macromolecule catabolic process GO:0043632 133 0.108
rna processing GO:0006396 105 0.101
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.097
macromolecule catabolic process GO:0009057 281 0.096
oocyte anterior posterior axis specification GO:0007314 2 0.094
covalent chromatin modification GO:0016569 163 0.087
cellular amine metabolic process GO:0044106 44 0.080
cellular response to dna damage stimulus GO:0006974 207 0.075
rna splicing GO:0008380 54 0.070
posttranscriptional regulation of gene expression GO:0010608 155 0.069
regulation of cellular amino acid metabolic process GO:0006521 5 0.068
cellular macromolecule catabolic process GO:0044265 206 0.066
histone modification GO:0016570 159 0.066
amine metabolic process GO:0009308 45 0.062
regulation of organelle organization GO:0033043 289 0.060
ubiquitin dependent protein catabolic process GO:0006511 129 0.059
cellularization GO:0007349 1 0.057
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.053
segmentation GO:0035282 93 0.051
regulation of transferase activity GO:0051338 263 0.051
cell maturation GO:0048469 127 0.050
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.046
regulation of cellular amine metabolic process GO:0033238 20 0.045
respiratory system development GO:0060541 190 0.044
regulation of apoptotic signaling pathway GO:2001233 197 0.043
Human
protein localization to organelle GO:0033365 185 0.043
histone h3 k9 dimethylation GO:0036123 4 0.042
peptidyl amino acid modification GO:0018193 336 0.042
cytoplasmic transport GO:0016482 234 0.040
respiratory tube development GO:0030323 167 0.040
regulation of lipid transport GO:0032368 36 0.039
intracellular mrna localization GO:0008298 4 0.039
dna metabolic process GO:0006259 303 0.038
positive regulation of programmed cell death GO:0043068 218 0.038
Human
regulation of protein stability GO:0031647 52 0.038
cellular amino acid metabolic process GO:0006520 103 0.036
negative regulation of molecular function GO:0044092 258 0.036
regulation of protein kinase activity GO:0045859 232 0.036
multicellular organism growth GO:0035264 161 0.036
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.035
asymmetric stem cell division GO:0098722 3 0.035
regulation of clathrin mediated endocytosis GO:2000369 4 0.035
negative regulation of protein modification process GO:0031400 163 0.035
dendrite development GO:0016358 115 0.034
muscle cell differentiation GO:0042692 261 0.034
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.034
endocytosis GO:0006897 168 0.033
regulation of cellular ketone metabolic process GO:0010565 66 0.033
lipid transport GO:0006869 98 0.033
canonical wnt signaling pathway GO:0060070 130 0.032
skeletal system morphogenesis GO:0048705 203 0.032
regulation of cell size GO:0008361 72 0.032
camera type eye development GO:0043010 266 0.032
regulation of cellular response to stress GO:0080135 159 0.032
regulation of histone modification GO:0031056 56 0.031
homeostasis of number of cells GO:0048872 210 0.031
protein acylation GO:0043543 64 0.030
proteasomal protein catabolic process GO:0010498 98 0.030
positive regulation of cellular amine metabolic process GO:0033240 5 0.030
inflammatory response GO:0006954 244 0.030
cellular ketone metabolic process GO:0042180 84 0.030
wnt signaling pathway GO:0016055 188 0.029
negative regulation of cellular component organization GO:0051129 194 0.029
cognition GO:0050890 149 0.029
maternal determination of anterior posterior axis embryo GO:0008358 2 0.029
regulation of lymphocyte activation GO:0051249 240 0.029
negative regulation of phosphorylation GO:0042326 166 0.028
lung development GO:0030324 164 0.028
microtubule cytoskeleton organization GO:0000226 157 0.027
regulation of mapk cascade GO:0043408 248 0.027
neural precursor cell proliferation GO:0061351 121 0.027
ossification GO:0001503 216 0.027
developmental maturation GO:0021700 193 0.027
cellular response to hormone stimulus GO:0032870 150 0.027
chromatin modification GO:0016568 187 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.027
t cell activation GO:0042110 289 0.027
regulation of cellular catabolic process GO:0031329 242 0.027
regulation of kinase activity GO:0043549 249 0.026
microtubule based process GO:0007017 236 0.026
mrna processing GO:0006397 63 0.026
regulation of t cell activation GO:0050863 170 0.026
establishment of protein localization to organelle GO:0072594 118 0.026
negative regulation of phosphate metabolic process GO:0045936 184 0.025
transcription from rna polymerase iii promoter GO:0006383 3 0.025
positive regulation of macroautophagy GO:0016239 3 0.025
lipid localization GO:0010876 126 0.025
erythrocyte differentiation GO:0030218 88 0.025
chemotaxis GO:0006935 247 0.024
renal system development GO:0072001 225 0.024
immune effector process GO:0002252 321 0.024
compound eye development GO:0048749 1 0.024
Fly
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.023
cardiac muscle tissue development GO:0048738 130 0.023
tube formation GO:0035148 140 0.023
negative regulation of cell cycle GO:0045786 123 0.023
regulation of chromosome organization GO:0033044 83 0.023
regulation of protein transport GO:0051223 163 0.023
protein targeting GO:0006605 143 0.023
negative regulation of cellular amine metabolic process GO:0033239 1 0.023
learning or memory GO:0007611 148 0.023
appendage development GO:0048736 166 0.023
regulation of myeloid cell differentiation GO:0045637 96 0.022
positive regulation of protein modification process GO:0031401 299 0.022
mesenchymal cell development GO:0014031 93 0.022
hormone secretion GO:0046879 128 0.022
regulation of cell activation GO:0050865 289 0.022
regulation of protein processing GO:0070613 96 0.022
myeloid cell homeostasis GO:0002262 114 0.022
urogenital system development GO:0001655 261 0.022
endocrine system development GO:0035270 98 0.022
response to radiation GO:0009314 165 0.022
regulation of chromatin modification GO:1903308 57 0.022
forebrain development GO:0030900 302 0.022
rna splicing via transesterification reactions GO:0000375 43 0.021
regulation of cellular component size GO:0032535 121 0.021
regulation of binding GO:0051098 111 0.021
regulation of neural precursor cell proliferation GO:2000177 70 0.021
response to light stimulus GO:0009416 135 0.020
multicellular organismal signaling GO:0035637 91 0.020
organelle localization GO:0051640 179 0.020
positive regulation of cell death GO:0010942 224 0.020
Human
mesenchyme development GO:0060485 152 0.020
leukocyte differentiation GO:0002521 342 0.020
regulation of translation GO:0006417 71 0.020
translation GO:0006412 93 0.020
regulation of leukocyte differentiation GO:1902105 159 0.019
peptidyl lysine modification GO:0018205 77 0.019
response to acid chemical GO:0001101 111 0.019
epithelial tube formation GO:0072175 130 0.019
stem cell development GO:0048864 219 0.019
regulation of secretion GO:0051046 274 0.019
positive regulation of apoptotic process GO:0043065 217 0.019
Human
lymphocyte differentiation GO:0030098 242 0.019
negative regulation of proteolysis GO:0045861 74 0.019
multi multicellular organism process GO:0044706 109 0.019
fat cell differentiation GO:0045444 160 0.019
negative regulation of apoptotic signaling pathway GO:2001234 104 0.019
nucleotide metabolic process GO:0009117 332 0.019
embryonic placenta development GO:0001892 98 0.019
carbohydrate homeostasis GO:0033500 128 0.019
notch signaling pathway GO:0007219 71 0.019
transmission of nerve impulse GO:0019226 76 0.018
sperm individualization GO:0007291 1 0.018
negative regulation of nervous system development GO:0051961 156 0.018
regulation of canonical wnt signaling pathway GO:0060828 82 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.018
nucleocytoplasmic transport GO:0006913 139 0.018
protein import into nucleus GO:0006606 95 0.018
i kappab kinase nf kappab signaling GO:0007249 85 0.018
protein import GO:0017038 101 0.018
histone acetylation GO:0016573 41 0.018
embryonic organ morphogenesis GO:0048562 276 0.018
response to transforming growth factor beta GO:0071559 88 0.018
peptide hormone secretion GO:0030072 109 0.018
blood vessel morphogenesis GO:0048514 285 0.018
cellular response to external stimulus GO:0071496 88 0.018
regulation of wnt signaling pathway GO:0030111 123 0.018
connective tissue development GO:0061448 179 0.017
oocyte development GO:0048599 33 0.017
regulation of membrane potential GO:0042391 192 0.017
neural tube development GO:0021915 160 0.017
glucose homeostasis GO:0042593 128 0.017
neuronal action potential GO:0019228 54 0.017
neuron projection guidance GO:0097485 141 0.017
male sex differentiation GO:0046661 109 0.017
cell fate commitment GO:0045165 210 0.017
apoptotic signaling pathway GO:0097190 306 0.017
Human
intracellular protein transport GO:0006886 204 0.017
lateral inhibition GO:0046331 1 0.017
regulation of protein localization GO:0032880 231 0.017
positive regulation of transferase activity GO:0051347 167 0.017
response to growth factor GO:0070848 198 0.017
regulation of ossification GO:0030278 112 0.017
mapk cascade GO:0000165 281 0.017
axon guidance GO:0007411 141 0.017
muscle tissue development GO:0060537 308 0.017
extrinsic apoptotic signaling pathway GO:0097191 126 0.017
regulation of hormone levels GO:0010817 211 0.017
regulation of cell cycle GO:0051726 281 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
cellular homeostasis GO:0019725 240 0.016
response to organonitrogen compound GO:0010243 246 0.016
positive regulation of wnt signaling pathway GO:0030177 45 0.016
regulation of chromatin silencing GO:0031935 2 0.016
p38mapk cascade GO:0038066 4 0.016
regulation of cell migration GO:0030334 219 0.016
response to insulin GO:0032868 100 0.016
regulation of cellular component biogenesis GO:0044087 181 0.016
mesenchymal cell differentiation GO:0048762 107 0.016
negative regulation of cell proliferation GO:0008285 296 0.016
negative regulation of kinase activity GO:0033673 81 0.016
dna recombination GO:0006310 92 0.016
axonogenesis GO:0007409 274 0.016
chromatin organization GO:0006325 206 0.016
protein methylation GO:0006479 81 0.015
spinal cord development GO:0021510 81 0.015
regulation of hormone secretion GO:0046883 88 0.015
cellular response to cytokine stimulus GO:0071345 189 0.015
regulation of adaptive immune response GO:0002819 90 0.015
positive regulation of cell development GO:0010720 237 0.015
amide transport GO:0042886 138 0.015
cellular response to nutrient levels GO:0031669 64 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
negative regulation of protein maturation GO:1903318 79 0.015
regulation of proteolysis GO:0030162 164 0.015
digestive system development GO:0055123 200 0.015
positive regulation of protein phosphorylation GO:0001934 242 0.015
blastoderm segmentation GO:0007350 13 0.015
regulation of rna splicing GO:0043484 37 0.015
negative regulation of immune system process GO:0002683 209 0.015
development of primary male sexual characteristics GO:0046546 88 0.015
b cell differentiation GO:0030183 78 0.015
kidney development GO:0001822 213 0.015
regulation of leukocyte mediated immunity GO:0002703 104 0.015
cerebral cortex development GO:0021987 86 0.015
myeloid cell differentiation GO:0030099 233 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.015
positive regulation of nervous system development GO:0051962 221 0.015
establishment or maintenance of cell polarity GO:0007163 86 0.014
positive regulation of homeostatic process GO:0032846 64 0.014
positive regulation of kinase activity GO:0033674 155 0.014
single organism cell adhesion GO:0098602 156 0.014
lymphocyte mediated immunity GO:0002449 139 0.014
nuclear import GO:0051170 95 0.014
negative regulation of mesenchymal cell proliferation GO:0072201 3 0.014
regulation of mitotic cell cycle GO:0007346 126 0.014
nuclear transport GO:0051169 139 0.014
regulation of protein catabolic process GO:0042176 108 0.014
negative regulation of lymphocyte activation GO:0051250 91 0.014
pancreas development GO:0031016 57 0.014
regulation of secretion by cell GO:1903530 249 0.014
peptide transport GO:0015833 133 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.014
segment specification GO:0007379 15 0.014
positive regulation of organelle organization GO:0010638 128 0.014
anatomical structure homeostasis GO:0060249 145 0.014
hematopoietic progenitor cell differentiation GO:0002244 143 0.014
regulation of homeostatic process GO:0032844 182 0.014
negative regulation of cell activation GO:0050866 111 0.014
oogenesis GO:0048477 56 0.014
carbohydrate derivative biosynthetic process GO:1901137 183 0.014
protein maturation GO:0051604 176 0.014
cellular response to extracellular stimulus GO:0031668 81 0.014
asymmetric neuroblast division GO:0055059 1 0.014
negative regulation of translation GO:0017148 22 0.014
stem cell differentiation GO:0048863 268 0.014
cell cycle checkpoint GO:0000075 47 0.014
regulation of protein maturation GO:1903317 96 0.014
skeletal muscle cell differentiation GO:0035914 66 0.014
striated muscle tissue development GO:0014706 293 0.014
regulation of erythrocyte differentiation GO:0045646 23 0.013
regulation of response to wounding GO:1903034 189 0.013
male gonad development GO:0008584 88 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
dorsal ventral axon guidance GO:0033563 3 0.013
positive regulation of intracellular transport GO:0032388 70 0.013
regulation of anatomical structure size GO:0090066 178 0.013
negative regulation of organelle organization GO:0010639 90 0.013
oocyte differentiation GO:0009994 35 0.013
mitotic cell cycle GO:0000278 195 0.013
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.013
positive regulation of protein transport GO:0051222 93 0.013
regulation of voltage gated calcium channel activity GO:1901385 4 0.013
chondrocyte hypertrophy GO:0003415 4 0.013
innate immune response GO:0045087 157 0.013
regulation of neuron differentiation GO:0045664 281 0.013
Fly
positive regulation of apoptotic signaling pathway GO:2001235 95 0.013
Human
negative regulation of protein phosphorylation GO:0001933 126 0.013
embryonic skeletal system development GO:0048706 120 0.013
histone methylation GO:0016571 71 0.013
regulation of chromatin organization GO:1902275 57 0.013
cellular response to growth factor stimulus GO:0071363 197 0.013
b cell activation GO:0042113 161 0.013
action potential GO:0001508 78 0.013
lung epithelium development GO:0060428 37 0.013
leukocyte mediated immunity GO:0002443 174 0.013
maintenance of location GO:0051235 89 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.013
inorganic cation transmembrane transport GO:0098662 207 0.013
embryonic epithelial tube formation GO:0001838 130 0.012
regulation of muscle tissue development GO:1901861 97 0.012
developmental growth involved in morphogenesis GO:0060560 138 0.012
telencephalon development GO:0021537 186 0.012
locomotory behavior GO:0007626 195 0.012
regulation of cytoskeleton organization GO:0051493 122 0.012
insulin secretion GO:0030073 89 0.012
negative regulation of protein processing GO:0010955 79 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.012
mrna metabolic process GO:0016071 84 0.012
nuclear division GO:0000280 158 0.012
cellular response to lipid GO:0071396 145 0.012
heart morphogenesis GO:0003007 178 0.012
regulation of system process GO:0044057 200 0.012
nucleobase containing small molecule metabolic process GO:0055086 352 0.012
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.012
nitrogen compound transport GO:0071705 271 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.012
stem cell proliferation GO:0072089 117 0.012
adaptive immune response GO:0002250 155 0.012
response to oxidative stress GO:0006979 123 0.012
hindbrain development GO:0030902 128 0.012
peptidyl lysine acetylation GO:0018394 45 0.012
mrna splicing via spliceosome GO:0000398 43 0.012
regulation of cytokine production GO:0001817 266 0.012
positive regulation of cell cycle GO:0045787 92 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
protein dna complex subunit organization GO:0071824 28 0.012
histone demethylation GO:0016577 13 0.012
regulation of inflammatory response GO:0050727 147 0.012
regulation of lymphocyte differentiation GO:0045619 107 0.012
regulation of mrna metabolic process GO:1903311 43 0.012
positive regulation of cell activation GO:0050867 158 0.012
cell growth GO:0016049 130 0.012
response to peptide hormone GO:0043434 127 0.012
organophosphate biosynthetic process GO:0090407 122 0.012
regulation of purine nucleotide metabolic process GO:1900542 169 0.012
carbohydrate metabolic process GO:0005975 230 0.012
cellular response to starvation GO:0009267 57 0.012
t cell proliferation GO:0042098 120 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
cellular lipid metabolic process GO:0044255 323 0.012
regulation of multi organism process GO:0043900 111 0.012
negative regulation of leukocyte differentiation GO:1902106 51 0.012
triglyceride biosynthetic process GO:0019432 17 0.012
positive regulation of creb transcription factor activity GO:0032793 4 0.012
positive regulation of secretion GO:0051047 130 0.011
meiosis i GO:0007127 60 0.011
gonad development GO:0008406 141 0.011
small molecule biosynthetic process GO:0044283 132 0.011
digestive tract morphogenesis GO:0048546 147 0.011
protein secretion GO:0009306 111 0.011
regulation of nucleoside metabolic process GO:0009118 130 0.011
multicellular organismal homeostasis GO:0048871 164 0.011
digestive tract development GO:0048565 190 0.011
gland development GO:0048732 330 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
defense response to other organism GO:0098542 197 0.011
response to monosaccharide GO:0034284 67 0.011
regulation of cell motility GO:2000145 236 0.011
macromolecule deacylation GO:0098732 37 0.011
regulation of neuron projection development GO:0010975 169 0.011
regulation of protein complex assembly GO:0043254 83 0.011
endothelial cell differentiation GO:0045446 41 0.011
feeding behavior GO:0007631 62 0.011
response to inorganic substance GO:0010035 96 0.011
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.011
bmp signaling pathway GO:0030509 93 0.011
organonitrogen compound biosynthetic process GO:1901566 192 0.011
wound healing GO:0042060 157 0.011
regulation of protein localization to nucleus GO:1900180 60 0.011
response to organic cyclic compound GO:0014070 198 0.011
pallium development GO:0021543 120 0.011
smoothened signaling pathway GO:0007224 105 0.011
protein processing GO:0016485 163 0.011
limb morphogenesis GO:0035108 149 0.011
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.011
regulation of cell adhesion GO:0030155 154 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
skeletal system development GO:0001501 356 0.011
purine containing compound metabolic process GO:0072521 311 0.011
stress activated mapk cascade GO:0051403 80 0.011
morphogenesis of embryonic epithelium GO:0016331 159 0.010
determination of left right symmetry GO:0007368 80 0.010
negative regulation of lymphocyte proliferation GO:0050672 45 0.010
cilium assembly GO:0042384 81 0.010
regulation of t cell proliferation GO:0042129 92 0.010
lymphocyte proliferation GO:0046651 164 0.010
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.010
regulation of cell projection organization GO:0031344 206 0.010
exocytosis GO:0006887 121 0.010
sperm motility GO:0030317 47 0.010
negative regulation of endopeptidase activity GO:0010951 44 0.010
negative regulation of chromosome organization GO:2001251 30 0.010
cartilage development GO:0051216 140 0.010
regulation of histone h3 k9 methylation GO:0051570 8 0.010
axon ensheathment GO:0008366 76 0.010
positive regulation of erythrocyte differentiation GO:0045648 11 0.010
sensory system development GO:0048880 3 0.010
regulation of feeding behavior GO:0060259 3 0.010
lymphocyte apoptotic process GO:0070227 54 0.010
nucleoside phosphate metabolic process GO:0006753 338 0.010
regulation of histone methylation GO:0031060 30 0.010
stem cell maintenance GO:0019827 130 0.010
methylation GO:0032259 134 0.010
receptor mediated endocytosis GO:0006898 51 0.010
immunoglobulin mediated immune response GO:0016064 69 0.010
negative regulation of cell fate specification GO:0009996 4 0.010
cell adhesion GO:0007155 329 0.010
regulation of fat cell differentiation GO:0045598 81 0.010

Siah1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
musculoskeletal system disease DOID:17 0 0.028
central nervous system disease DOID:331 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
sensory system disease DOID:0050155 0 0.011