|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
0.948
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.937
|
Fly |
|
|
immature b cell differentiation
|
GO:0002327 |
10 |
0.929
|
|
|
|
substrate dependent cell migration cell extension
|
GO:0006930 |
4 |
0.927
|
Mouse |
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
0.904
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.851
|
|
|
|
metencephalon development
|
GO:0022037 |
89 |
0.834
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
261 |
0.815
|
|
|
|
extracellular matrix organization
|
GO:0030198 |
147 |
0.803
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.781
|
Mouse |
|
|
chemotaxis
|
GO:0006935 |
247 |
0.779
|
Fly |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
194 |
0.709
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.704
|
|
|
|
regulation of engulfment of apoptotic cell
|
GO:1901074 |
2 |
0.686
|
Worm |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.681
|
|
|
|
alpha beta t cell differentiation
|
GO:0046632 |
69 |
0.658
|
|
|
|
b cell differentiation
|
GO:0030183 |
78 |
0.651
|
|
|
|
b cell activation involved in immune response
|
GO:0002312 |
50 |
0.645
|
|
|
|
visual behavior
|
GO:0007632 |
45 |
0.637
|
Mouse |
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.629
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
18 |
0.621
|
Mouse |
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.602
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.592
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.579
|
Mouse |
|
|
negative regulation of cellular component organization
|
GO:0051129 |
194 |
0.575
|
Worm Fly |
|
|
associative learning
|
GO:0008306 |
61 |
0.570
|
Mouse |
|
|
negative regulation of rho protein signal transduction
|
GO:0035024 |
7 |
0.540
|
Mouse |
|
|
axonogenesis
|
GO:0007409 |
274 |
0.534
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.515
|
Human |
|
|
digestive system development
|
GO:0055123 |
200 |
0.513
|
Fly |
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.512
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.511
|
Human |
|
|
b cell homeostasis
|
GO:0001782 |
34 |
0.492
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
147 |
0.489
|
Fly |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
0.487
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.487
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.476
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
9 |
0.452
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.446
|
|
|
|
synapse organization
|
GO:0050808 |
125 |
0.435
|
Fly |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.431
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.429
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.423
|
Mouse |
|
|
regulation of feeding behavior
|
GO:0060259 |
3 |
0.418
|
|
|
|
morphogenesis of a polarized epithelium
|
GO:0001738 |
37 |
0.416
|
Fly |
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.411
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
119 |
0.407
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.404
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.396
|
Fly |
|
|
camera type eye development
|
GO:0043010 |
266 |
0.396
|
|
|
|
hindbrain development
|
GO:0030902 |
128 |
0.396
|
|
|
|
response to light stimulus
|
GO:0009416 |
135 |
0.394
|
Mouse |
|
|
optic placode formation
|
GO:0001743 |
2 |
0.391
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.389
|
|
|
|
regulation of interleukin 2 secretion
|
GO:1900040 |
6 |
0.382
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.379
|
|
|
|
regulation of phospholipase c activity
|
GO:1900274 |
3 |
0.373
|
Human |
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.367
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
224 |
0.357
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.334
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.330
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.329
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.326
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.323
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.323
|
Human |
|
|
response to growth factor
|
GO:0070848 |
198 |
0.316
|
|
|
|
regulation of protein transport
|
GO:0051223 |
163 |
0.313
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.311
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.309
|
Human |
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
51 |
0.309
|
Worm |
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
193 |
0.299
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.298
|
|
|
|
regulation of interleukin 2 production
|
GO:0032663 |
28 |
0.296
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.288
|
Mouse |
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.285
|
Human |
|
|
negative regulation of cellular senescence
|
GO:2000773 |
3 |
0.280
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
42 |
0.277
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.276
|
|
|
|
dna metabolic process
|
GO:0006259 |
303 |
0.274
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
148 |
0.272
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
130 |
0.269
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.269
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.265
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.263
|
|
|
|
positive regulation of binding
|
GO:0051099 |
49 |
0.263
|
Mouse |
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.263
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
281 |
0.263
|
Mouse |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.262
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.259
|
|
|
|
epithelial cell development
|
GO:0002064 |
159 |
0.258
|
Fly |
|
|
regionalization
|
GO:0003002 |
337 |
0.256
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.255
|
Human |
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.253
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.249
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.248
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
32 |
0.248
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.248
|
|
|
|
learning
|
GO:0007612 |
98 |
0.244
|
Mouse |
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.244
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.240
|
Human |
|
|
nuclear transport
|
GO:0051169 |
139 |
0.230
|
Fly |
|
|
alpha beta t cell activation
|
GO:0046631 |
91 |
0.228
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.225
|
Mouse |
|
|
bmp signaling pathway
|
GO:0030509 |
93 |
0.225
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.225
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.224
|
Fly |
|
|
interleukin 2 secretion
|
GO:0070970 |
7 |
0.215
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.215
|
|
|
|
myotube differentiation
|
GO:0014902 |
105 |
0.215
|
|
|
|
positive regulation of interferon gamma secretion
|
GO:1902715 |
3 |
0.213
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.213
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.213
|
|
|
|
chromatin organization
|
GO:0006325 |
206 |
0.210
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.208
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.207
|
Human |
|
|
gland development
|
GO:0048732 |
330 |
0.207
|
|
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.207
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.205
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.204
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.203
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.203
|
|
|
|
cardiac right ventricle formation
|
GO:0003219 |
3 |
0.200
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.200
|
|
|
|
cellular response to lipid
|
GO:0071396 |
145 |
0.194
|
|
|
|
substrate dependent cell migration
|
GO:0006929 |
18 |
0.193
|
Mouse |
|
|
visual learning
|
GO:0008542 |
44 |
0.189
|
Mouse |
|
|
regulation of protein complex assembly
|
GO:0043254 |
83 |
0.188
|
|
|
|
negative regulation of anoikis
|
GO:2000811 |
2 |
0.187
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.185
|
|
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.182
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
54 |
0.180
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
26 |
0.179
|
Fly |
|
|
anatomical structure homeostasis
|
GO:0060249 |
145 |
0.178
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
172 |
0.177
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
237 |
0.176
|
Mouse |
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
54 |
0.176
|
|
|
|
membrane invagination
|
GO:0010324 |
17 |
0.176
|
Worm |
|
|
regulation of organelle organization
|
GO:0033043 |
289 |
0.175
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.173
|
Fly |
|
|
gliogenesis
|
GO:0042063 |
141 |
0.173
|
|
|
|
skeletal system development
|
GO:0001501 |
356 |
0.171
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.171
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
92 |
0.170
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.168
|
|
|
|
retina morphogenesis in camera type eye
|
GO:0060042 |
45 |
0.167
|
|
|
|
cerebellum morphogenesis
|
GO:0021587 |
42 |
0.167
|
|
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
55 |
0.166
|
|
|
|
skeletal muscle organ development
|
GO:0060538 |
163 |
0.166
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
28 |
0.166
|
|
|
|
response to radiation
|
GO:0009314 |
165 |
0.164
|
Mouse Worm |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.163
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.163
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.162
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.162
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.160
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
122 |
0.159
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
52 |
0.159
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
121 |
0.159
|
|
|
|
muscle cell development
|
GO:0055001 |
133 |
0.159
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.158
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
45 |
0.157
|
|
|
|
vesicle localization
|
GO:0051648 |
86 |
0.157
|
|
|
|
fibroblast growth factor receptor signaling pathway
|
GO:0008543 |
46 |
0.156
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
123 |
0.155
|
|
|
|
optic placode formation involved in camera type eye formation
|
GO:0046619 |
2 |
0.155
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
45 |
0.154
|
|
|
|
positive regulation of protein export from nucleus
|
GO:0046827 |
4 |
0.153
|
Fly |
|
|
digestive tract development
|
GO:0048565 |
190 |
0.153
|
Fly |
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.153
|
|
|
|
t cell anergy
|
GO:0002870 |
4 |
0.152
|
|
|
|
interleukin 2 production
|
GO:0032623 |
33 |
0.151
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.150
|
|
|
|
defense response to other organism
|
GO:0098542 |
197 |
0.148
|
Worm |
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
61 |
0.147
|
|
|
|
negative regulation of synapse assembly
|
GO:0051964 |
3 |
0.146
|
Fly |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.146
|
|
|
|
lymphocyte activation involved in immune response
|
GO:0002285 |
93 |
0.146
|
|
|
|
actin filament polymerization
|
GO:0030041 |
44 |
0.145
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.144
|
|
|
|
negative regulation of bmp signaling pathway
|
GO:0030514 |
35 |
0.143
|
|
|
|
striated muscle tissue development
|
GO:0014706 |
293 |
0.142
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
0.141
|
|
|
|
organ growth
|
GO:0035265 |
117 |
0.141
|
|
|
|
positive regulation of t cell anergy
|
GO:0002669 |
4 |
0.140
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.140
|
|
|
|
protein secretion
|
GO:0009306 |
111 |
0.139
|
|
|
|
neuron projection guidance
|
GO:0097485 |
141 |
0.138
|
Fly |
|
|
adenylate cyclase inhibiting g protein coupled receptor signaling pathway
|
GO:0007193 |
20 |
0.137
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.137
|
|
|
|
regulation of lymphocyte anergy
|
GO:0002911 |
4 |
0.136
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
276 |
0.136
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.136
|
Human |
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.135
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.132
|
|
|
|
thymus development
|
GO:0048538 |
41 |
0.131
|
|
|
|
positive regulation of non canonical wnt signaling pathway
|
GO:2000052 |
6 |
0.130
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.130
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
128 |
0.129
|
|
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.129
|
|
|
|
chromatin modification
|
GO:0016568 |
187 |
0.128
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.127
|
|
|
|
regulation of t cell anergy
|
GO:0002667 |
4 |
0.126
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.126
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.125
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.125
|
|
|
|
developmental growth involved in morphogenesis
|
GO:0060560 |
138 |
0.120
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
122 |
0.120
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
73 |
0.119
|
Fly |
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.118
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.116
|
|
|
|
calcium ion transport
|
GO:0006816 |
159 |
0.115
|
|
|
|
ribonucleoside metabolic process
|
GO:0009119 |
245 |
0.115
|
|
|
|
regulation of protein binding
|
GO:0043393 |
60 |
0.115
|
Mouse |
|
|
regulation of chromatin modification
|
GO:1903308 |
57 |
0.115
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
32 |
0.113
|
|
|
|
positive regulation of phospholipase c activity
|
GO:0010863 |
2 |
0.113
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
164 |
0.112
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
82 |
0.110
|
Fly |
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.110
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
213 |
0.110
|
|
|
|
protein kinase c signaling
|
GO:0070528 |
7 |
0.109
|
|
|
|
segmentation
|
GO:0035282 |
93 |
0.109
|
|
|
|
negative regulation of growth
|
GO:0045926 |
99 |
0.109
|
Fly |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.109
|
|
|
|
cognition
|
GO:0050890 |
149 |
0.109
|
Mouse |
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.109
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
61 |
0.106
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
141 |
0.106
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.106
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
218 |
0.105
|
|
|
|
cardiac ventricle development
|
GO:0003231 |
83 |
0.105
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.104
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.104
|
Human |
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
141 |
0.103
|
Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.103
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
69 |
0.103
|
Worm |
|
|
spleen development
|
GO:0048536 |
39 |
0.102
|
|
|
|
muscle tissue development
|
GO:0060537 |
308 |
0.102
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.101
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.101
|
|
|
|
learning or memory
|
GO:0007611 |
148 |
0.101
|
Mouse |
|
|
cytoplasmic transport
|
GO:0016482 |
234 |
0.101
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.101
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.101
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.100
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
192 |
0.100
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.099
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
93 |
0.098
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
3 |
0.097
|
Worm |
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.097
|
Fly |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
114 |
0.097
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
182 |
0.096
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.096
|
Human |
|
|
regulation of striated muscle cell differentiation
|
GO:0051153 |
81 |
0.096
|
|
|
|
positive regulation of muscle cell differentiation
|
GO:0051149 |
39 |
0.096
|
|
|
|
establishment or maintenance of cell polarity
|
GO:0007163 |
86 |
0.096
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.095
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.095
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.095
|
|
|
|
positive regulation of histone modification
|
GO:0031058 |
28 |
0.094
|
|
|
|
regulation of organ growth
|
GO:0046620 |
61 |
0.094
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
52 |
0.093
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.093
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.092
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
71 |
0.092
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.092
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
80 |
0.091
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
243 |
0.091
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.091
|
Human |
|
|
regulation of protein stability
|
GO:0031647 |
52 |
0.091
|
Fly |
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.090
|
|
|
|
endothelial cell apoptotic process
|
GO:0072577 |
9 |
0.090
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.090
|
|
|
|
synaptic growth at neuromuscular junction
|
GO:0051124 |
6 |
0.089
|
Fly |
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.089
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
203 |
0.089
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.088
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.086
|
|
|
|
regulation of cell aging
|
GO:0090342 |
9 |
0.086
|
|
|
|
regulation of cell motility
|
GO:2000145 |
236 |
0.086
|
Worm |
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.086
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
58 |
0.086
|
|
|
|
regulation of muscle tissue development
|
GO:1901861 |
97 |
0.086
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.086
|
Fly |
|
|
negative regulation of organ growth
|
GO:0046621 |
17 |
0.085
|
|
|
|
somatic diversification of immune receptors via germline recombination within a single locus
|
GO:0002562 |
51 |
0.085
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.084
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.084
|
|
|
|
formation of radial glial scaffolds
|
GO:0021943 |
4 |
0.084
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.084
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
116 |
0.084
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
40 |
0.083
|
Mouse |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.083
|
|
|
|
neuron migration
|
GO:0001764 |
122 |
0.082
|
Fly |
|
|
regulation of synapse assembly
|
GO:0051963 |
29 |
0.081
|
Fly |
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.081
|
|
|
|
ribose phosphate metabolic process
|
GO:0019693 |
291 |
0.081
|
|
|
|
neuroblast fate determination
|
GO:0007400 |
1 |
0.081
|
|
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
46 |
0.080
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
47 |
0.080
|
Worm |
|
|
positive regulation of lymphocyte anergy
|
GO:0002913 |
4 |
0.080
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.080
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.079
|
Human |
|
|
response to insulin
|
GO:0032868 |
100 |
0.079
|
|
|
|
positive regulation of neuron death
|
GO:1901216 |
28 |
0.079
|
|
|
|
response to acid chemical
|
GO:0001101 |
111 |
0.079
|
|
|
|
dendrite development
|
GO:0016358 |
115 |
0.078
|
Mouse |
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.078
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.077
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.076
|
|
|
|
fat cell differentiation
|
GO:0045444 |
160 |
0.076
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.075
|
Mouse |
|
|
lung alveolus development
|
GO:0048286 |
45 |
0.075
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.075
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.075
|
Worm |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.074
|
|
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.074
|
|
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.074
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
30 |
0.074
|
Fly |
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
4 |
0.073
|
|
|
|
lymphocyte anergy
|
GO:0002249 |
4 |
0.072
|
|
|
|
negative regulation of cell aging
|
GO:0090344 |
5 |
0.072
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
62 |
0.072
|
|
|
|
negative regulation of apoptotic cell clearance
|
GO:2000426 |
1 |
0.072
|
Worm |
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.072
|
Human |
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
34 |
0.072
|
Human Worm |
|
|
positive regulation of immature t cell proliferation
|
GO:0033091 |
4 |
0.072
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.071
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.071
|
|
|
|
glial cell differentiation
|
GO:0010001 |
131 |
0.071
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
27 |
0.071
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.071
|
|
|
|
wnt signaling pathway planar cell polarity pathway
|
GO:0060071 |
27 |
0.070
|
|
|
|
inositol phosphate catabolic process
|
GO:0071545 |
4 |
0.070
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
126 |
0.069
|
|
|
|
integrin mediated signaling pathway
|
GO:0007229 |
27 |
0.069
|
|
|
|
astrocyte differentiation
|
GO:0048708 |
43 |
0.069
|
|
|
|
wound healing
|
GO:0042060 |
157 |
0.068
|
|
|
|
regulation of anoikis
|
GO:2000209 |
2 |
0.067
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
88 |
0.067
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
26 |
0.067
|
Worm |
|
|
maintenance of location
|
GO:0051235 |
89 |
0.067
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
70 |
0.067
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.066
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
49 |
0.066
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.066
|
Mouse |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.065
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.065
|
|
|
|
negative regulation of chromosome organization
|
GO:2001251 |
30 |
0.065
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.065
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
106 |
0.065
|
|
|
|
feeding behavior
|
GO:0007631 |
62 |
0.064
|
|
|
|
negative regulation of fat cell differentiation
|
GO:0045599 |
36 |
0.064
|
|
|
|
cardiac chamber development
|
GO:0003205 |
108 |
0.064
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.064
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
19 |
0.063
|
Worm |
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.063
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
83 |
0.062
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.062
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
109 |
0.062
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
174 |
0.062
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.061
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
46 |
0.061
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
0 |
0.061
|
|
|
|
positive regulation of synaptic growth at neuromuscular junction
|
GO:0045887 |
1 |
0.061
|
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.061
|
Worm |
|
|
stem cell proliferation
|
GO:0072089 |
117 |
0.061
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
61 |
0.060
|
Worm |
|
|
nucleotide biosynthetic process
|
GO:0009165 |
78 |
0.060
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
210 |
0.060
|
|
|
|
retina development in camera type eye
|
GO:0060041 |
119 |
0.060
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
85 |
0.060
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
68 |
0.059
|
|
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
47 |
0.059
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
174 |
0.059
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
34 |
0.059
|
|
|
|
substrate adhesion dependent cell spreading
|
GO:0034446 |
30 |
0.059
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.058
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
79 |
0.058
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.058
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
92 |
0.058
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.058
|
|
|
|
neural precursor cell proliferation
|
GO:0061351 |
121 |
0.058
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
90 |
0.058
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.058
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
361 |
0.057
|
|
|
|
cell fate determination involved in pattern specification
|
GO:0060582 |
1 |
0.057
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.057
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.057
|
|
|
|
regulation of autophagy
|
GO:0010506 |
30 |
0.056
|
|
|
|
embryonic placenta development
|
GO:0001892 |
98 |
0.055
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.055
|
|
|
|
positive regulation of phospholipase activity
|
GO:0010518 |
3 |
0.055
|
|
|
|
cell growth
|
GO:0016049 |
130 |
0.055
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.055
|
|
|
|
multicellular organism growth
|
GO:0035264 |
161 |
0.055
|
|
|
|
prostate gland development
|
GO:0030850 |
48 |
0.055
|
|
|
|
positive regulation of wnt signaling pathway planar cell polarity pathway
|
GO:2000096 |
5 |
0.054
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.054
|
|
|
|
skeletal muscle cell differentiation
|
GO:0035914 |
66 |
0.054
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
65 |
0.054
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
118 |
0.054
|
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.053
|
Worm |
|
|
second messenger mediated signaling
|
GO:0019932 |
73 |
0.053
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.052
|
|
|
|
ossification
|
GO:0001503 |
216 |
0.051
|
|
|
|
positive regulation of fibroblast growth factor receptor signaling pathway
|
GO:0045743 |
3 |
0.051
|
|
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.051
|
|
|
|
positive regulation of chromatin modification
|
GO:1903310 |
28 |
0.051
|
|
|
|
myofibril assembly
|
GO:0030239 |
34 |
0.051
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.050
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
65 |
0.050
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.049
|
|
|
|
negative regulation of ossification
|
GO:0030279 |
49 |
0.049
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.049
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.049
|
|
|
|
cell recognition
|
GO:0008037 |
83 |
0.049
|
Fly |
|
|
carbohydrate metabolic process
|
GO:0005975 |
230 |
0.049
|
|
|
|
regulation of tissue remodeling
|
GO:0034103 |
38 |
0.049
|
|
|
|
somatic diversification of immune receptors
|
GO:0002200 |
53 |
0.049
|
|
|
|
bone remodeling
|
GO:0046849 |
53 |
0.049
|
|
|
|
neuroblast differentiation
|
GO:0014016 |
2 |
0.049
|
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
44 |
0.049
|
|
|
|
membrane organization
|
GO:0061024 |
245 |
0.049
|
Worm |
|
|
regulation of chromatin organization
|
GO:1902275 |
57 |
0.048
|
|
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
7 |
0.048
|
|
|
|
negative regulation of insulin receptor signaling pathway
|
GO:0046627 |
14 |
0.048
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
268 |
0.048
|
|
|
|
neuron death
|
GO:0070997 |
154 |
0.048
|
|
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
38 |
0.048
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.047
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.047
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
114 |
0.047
|
|
|
|
circulatory system process
|
GO:0003013 |
197 |
0.046
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
127 |
0.046
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
95 |
0.046
|
|
|
|
protein import
|
GO:0017038 |
101 |
0.046
|
|
|
|
adaptive immune response
|
GO:0002250 |
155 |
0.046
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.046
|
|
|
|
striated muscle cell proliferation
|
GO:0014855 |
39 |
0.046
|
|
|
|
response to fibroblast growth factor
|
GO:0071774 |
47 |
0.046
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
62 |
0.046
|
|
|
|
negative regulation of response to dna damage stimulus
|
GO:2001021 |
10 |
0.045
|
Worm |
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
68 |
0.045
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
103 |
0.045
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
59 |
0.045
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
159 |
0.044
|
|
|
|
lymphocyte mediated immunity
|
GO:0002449 |
139 |
0.044
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.044
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
122 |
0.044
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.044
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
178 |
0.044
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
70 |
0.044
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.044
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
40 |
0.044
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.043
|
|
|
|
regulation of cellular senescence
|
GO:2000772 |
6 |
0.043
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.043
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.043
|
|
|
|
regulation of inositol trisphosphate biosynthetic process
|
GO:0032960 |
3 |
0.043
|
|
|
|
regulation of neuron death
|
GO:1901214 |
134 |
0.043
|
|
|
|
endocrine system development
|
GO:0035270 |
98 |
0.043
|
|
|
|
cellular senescence
|
GO:0090398 |
11 |
0.043
|
|
|
|
phagocytosis engulfment
|
GO:0006911 |
16 |
0.043
|
Worm |
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.043
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.043
|
|
|
|
regulation of interferon gamma secretion
|
GO:1902713 |
3 |
0.042
|
|
|
|
microtubule based process
|
GO:0007017 |
236 |
0.042
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
4 |
0.042
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
76 |
0.042
|
|
|
|
blood circulation
|
GO:0008015 |
195 |
0.042
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
207 |
0.042
|
Human Worm |
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.042
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.041
|
|
|
|
organelle assembly
|
GO:0070925 |
177 |
0.041
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
266 |
0.041
|
|
|
|
negative regulation of interleukin 6 production
|
GO:0032715 |
17 |
0.041
|
|
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
3 |
0.041
|
|
|
|
negative regulation of b cell activation
|
GO:0050869 |
27 |
0.040
|
|
|
|
axon ensheathment
|
GO:0008366 |
76 |
0.040
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
95 |
0.040
|
Mouse |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.040
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
80 |
0.040
|
|
|
|
negative regulation of glial cell proliferation
|
GO:0060253 |
4 |
0.040
|
|
|
|
prostate glandular acinus development
|
GO:0060525 |
12 |
0.040
|
|
|
|
negative regulation of nervous system development
|
GO:0051961 |
156 |
0.039
|
Fly |
|
|
response to ionizing radiation
|
GO:0010212 |
42 |
0.039
|
Worm |
|
|
protein import into nucleus
|
GO:0006606 |
95 |
0.039
|
|
|
|
positive regulation of keratinocyte proliferation
|
GO:0010838 |
4 |
0.039
|
|
|
|
cardiac muscle cell proliferation
|
GO:0060038 |
31 |
0.039
|
|
|
|
sprouting angiogenesis
|
GO:0002040 |
26 |
0.039
|
|
|
|
carbohydrate biosynthetic process
|
GO:0016051 |
74 |
0.039
|
|
