Mus musculus

63 known processes

Actn2

actinin alpha 2

(Aliases: MGC107582,1110008F24Rik)

Actn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin cytoskeleton organization GO:0030036 220 0.995
Zebrafish Mouse Fly
striated muscle contraction GO:0006941 45 0.992
cellular component assembly involved in morphogenesis GO:0010927 139 0.990
Zebrafish Fly
muscle cell development GO:0055001 133 0.987
Zebrafish Fly
muscle contraction GO:0006936 101 0.986
sarcomere organization GO:0045214 24 0.985
Zebrafish Fly
regulation of muscle system process GO:0090257 80 0.981
muscle system process GO:0003012 141 0.980
organelle assembly GO:0070925 177 0.978
Zebrafish Fly
muscle tissue development GO:0060537 308 0.976
Zebrafish
heart contraction GO:0060047 93 0.967
regulation of the force of heart contraction GO:0002026 17 0.967
skeletal muscle thin filament assembly GO:0030240 2 0.940
regulation of heart contraction GO:0008016 77 0.940
blood circulation GO:0008015 195 0.932
myofibril assembly GO:0030239 34 0.922
Zebrafish Fly
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 10 0.913
skeletal myofibril assembly GO:0014866 4 0.892
actomyosin structure organization GO:0031032 56 0.872
Zebrafish Fly
peptidyl serine autophosphorylation GO:0036289 1 0.852
skeletal muscle adaptation GO:0043501 16 0.845
regulation of system process GO:0044057 200 0.844
muscle cell differentiation GO:0042692 261 0.834
Zebrafish Fly
cardiac muscle tissue development GO:0048738 130 0.834
regulation of skeletal muscle contraction GO:0014819 3 0.830
muscle filament sliding GO:0030049 1 0.827
regulation of relaxation of muscle GO:1901077 8 0.816
regulation of muscle contraction GO:0006937 49 0.812
myosin filament organization GO:0031033 3 0.808
cardiac myofibril assembly GO:0055003 12 0.794
striated muscle myosin thick filament assembly GO:0071688 1 0.782
circulatory system process GO:0003013 197 0.781
striated muscle cell development GO:0055002 125 0.769
Zebrafish Fly
heart process GO:0003015 94 0.766
response to isoquinoline alkaloid GO:0014072 9 0.754
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 7 0.737
cardiac muscle cell development GO:0055013 39 0.719
regulation of atp catabolic process GO:1903289 9 0.710
cardiac muscle contraction GO:0060048 32 0.682
actin myosin filament sliding GO:0033275 1 0.679
transition between fast and slow fiber GO:0014883 9 0.677
purine nucleoside metabolic process GO:0042278 241 0.672
cellular metal ion homeostasis GO:0006875 151 0.670
regulation of ion transport GO:0043269 215 0.666
Human
nucleoside phosphate catabolic process GO:1901292 222 0.654
regulation of muscle adaptation GO:0043502 31 0.630
cardiac muscle cell differentiation GO:0055007 69 0.627
striated muscle tissue development GO:0014706 293 0.589
Zebrafish
apoptotic signaling pathway GO:0097190 306 0.587
myotube differentiation GO:0014902 105 0.572
Zebrafish
actin filament organization GO:0007015 113 0.571
Mouse
response to morphine GO:0043278 9 0.568
response to muscle stretch GO:0035994 1 0.564
ribonucleoside triphosphate catabolic process GO:0009203 199 0.562
cation transport GO:0006812 399 0.561
Human
regulation of cellular catabolic process GO:0031329 242 0.555
muscle adaptation GO:0043500 39 0.553
regulation of ion transmembrane transport GO:0034765 119 0.549
Human
actin filament based movement GO:0030048 23 0.528
regulation of skeletal muscle adaptation GO:0014733 12 0.525
negative regulation of potassium ion transmembrane transporter activity GO:1901017 3 0.514
Human
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.512
regulation of blood circulation GO:1903522 93 0.511
mitochondrion organization GO:0007005 134 0.510
peptidyl serine modification GO:0018209 83 0.504
sequestering of calcium ion GO:0051208 18 0.500
regulation of organelle organization GO:0033043 289 0.493
cardiocyte differentiation GO:0035051 87 0.492
cardiac muscle tissue morphogenesis GO:0055008 44 0.491
nucleoside triphosphate metabolic process GO:0009141 230 0.484
regulation of cytoskeleton organization GO:0051493 122 0.481
muscle fiber development GO:0048747 76 0.474
Zebrafish
actin polymerization or depolymerization GO:0008154 54 0.473
regulation of apoptotic signaling pathway GO:2001233 197 0.472
positive regulation of lipid catabolic process GO:0050996 6 0.461
positive regulation of cardiac muscle cell apoptotic process GO:0010666 3 0.449
positive regulation of leukocyte differentiation GO:1902107 86 0.436
aromatic compound catabolic process GO:0019439 286 0.434
regulation of actin cytoskeleton organization GO:0032956 84 0.412
calcium ion transport from endoplasmic reticulum to cytosol GO:1903514 12 0.406
myosin filament assembly GO:0031034 2 0.405
calcium ion transmembrane transport GO:0070588 85 0.400
regulation of striated muscle contraction GO:0006942 25 0.396
cell type specific apoptotic process GO:0097285 268 0.394
ribonucleoside metabolic process GO:0009119 245 0.390
ribonucleoside catabolic process GO:0042454 206 0.387
activation of meiosis GO:0090427 4 0.384
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.382
response to inorganic substance GO:0010035 96 0.373
actin filament polymerization GO:0030041 44 0.369
regulation of leukocyte differentiation GO:1902105 159 0.366
activation of meiosis involved in egg activation GO:0060466 2 0.365
synaptic transmission gabaergic GO:0051932 19 0.361
ribonucleotide metabolic process GO:0009259 291 0.358
nuclear division GO:0000280 158 0.353
Worm
macromolecule catabolic process GO:0009057 281 0.350
Worm
calcium ion homeostasis GO:0055074 127 0.341
cardiac cell development GO:0055006 41 0.339
calcium ion transport into cytosol GO:0060402 48 0.336
response to alkaloid GO:0043279 34 0.335
glycosyl compound catabolic process GO:1901658 206 0.332
positive regulation of calcium ion transport GO:0051928 27 0.332
cellular response to ethanol GO:0071361 3 0.327
cellular response to growth factor stimulus GO:0071363 197 0.326
response to ammonium ion GO:0060359 21 0.323
regulation of insulin receptor signaling pathway GO:0046626 21 0.322
regulation of actin filament based process GO:0032970 99 0.321
synaptic transmission GO:0007268 329 0.317
nucleobase containing small molecule metabolic process GO:0055086 352 0.313
monosaccharide metabolic process GO:0005996 106 0.310
response to ethanol GO:0045471 18 0.309
peptidyl threonine phosphorylation GO:0018107 31 0.302
glycosyl compound metabolic process GO:1901657 246 0.302
heart morphogenesis GO:0003007 178 0.299
regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 9 0.296
regulation of cell cycle process GO:0010564 160 0.293
epidermis development GO:0008544 187 0.291
purine nucleoside catabolic process GO:0006152 205 0.289
purine nucleoside triphosphate metabolic process GO:0009144 226 0.288
cation homeostasis GO:0055080 212 0.286
organic cyclic compound catabolic process GO:1901361 295 0.278
cellular ion homeostasis GO:0006873 165 0.278
negative regulation of homeostatic process GO:0032845 71 0.276
cell division GO:0051301 120 0.276
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.274
cellular macromolecule catabolic process GO:0044265 206 0.271
negative regulation of intracellular signal transduction GO:1902532 167 0.271
regulation of ion transmembrane transporter activity GO:0032412 54 0.270
Human
purine nucleotide metabolic process GO:0006163 302 0.268
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.267
positive regulation of organelle organization GO:0010638 128 0.267
purine ribonucleotide catabolic process GO:0009154 208 0.264
regulation of calcium ion transport GO:0051924 69 0.263
protein catabolic process GO:0030163 221 0.258
Worm
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.252
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.252
organophosphate catabolic process GO:0046434 232 0.250
ribonucleotide catabolic process GO:0009261 208 0.249
calcium ion transport GO:0006816 159 0.245
organelle fission GO:0048285 170 0.242
Worm
neuron neuron synaptic transmission GO:0007270 69 0.240
nucleoside phosphate metabolic process GO:0006753 338 0.236
nucleotide catabolic process GO:0009166 217 0.235
ribonucleoside monophosphate catabolic process GO:0009158 57 0.234
purine ribonucleotide metabolic process GO:0009150 290 0.232
cytosolic calcium ion transport GO:0060401 48 0.232
regulation of cell projection organization GO:0031344 206 0.231
response to heat GO:0009408 27 0.231
endoplasmic reticulum to cytosol transport GO:1903513 12 0.231
regulation of calcium ion transport into cytosol GO:0010522 31 0.230
ribose phosphate metabolic process GO:0019693 291 0.229
striated muscle adaptation GO:0014888 26 0.228
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.223
atp catabolic process GO:0006200 55 0.220
skeletal muscle fiber development GO:0048741 58 0.220
Zebrafish
regulation of actin filament length GO:0030832 45 0.220
regulation of nucleoside metabolic process GO:0009118 130 0.219
cellular chemical homeostasis GO:0055082 215 0.219
ras protein signal transduction GO:0007265 77 0.218
ovulation GO:0030728 15 0.216
ventricular cardiac muscle cell action potential GO:0086005 4 0.214
heterocycle catabolic process GO:0046700 280 0.213
regulation of sarcomere organization GO:0060297 4 0.211
mitotic cell cycle GO:0000278 195 0.208
Worm
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.207
positive regulation of programmed cell death GO:0043068 218 0.202
purine containing compound catabolic process GO:0072523 213 0.202
regulation of positive chemotaxis GO:0050926 7 0.201
skeletal muscle organ development GO:0060538 163 0.199
Zebrafish
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.196
protein localization to membrane GO:0072657 108 0.195
response to oxygen levels GO:0070482 62 0.194
positive regulation of ion transport GO:0043270 65 0.194
Human
negative regulation of organelle organization GO:0010639 90 0.193
positive regulation of vesicle fusion GO:0031340 2 0.192
meiotic cell cycle GO:0051321 122 0.190
muscle tissue morphogenesis GO:0060415 53 0.188
regulation of cellular component biogenesis GO:0044087 181 0.187
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.186
second messenger mediated signaling GO:0019932 73 0.182
regulation of nucleotide catabolic process GO:0030811 122 0.179
relaxation of cardiac muscle GO:0055119 9 0.179
regulation of t cell activation GO:0050863 170 0.179
regulation of neuronal synaptic plasticity GO:0048168 30 0.178
purine nucleoside monophosphate catabolic process GO:0009128 58 0.178
sequestering of metal ion GO:0051238 19 0.176
regulation of relaxation of cardiac muscle GO:1901897 6 0.176
cellular calcium ion homeostasis GO:0006874 119 0.176
cytoplasmic transport GO:0016482 234 0.176
response to ischemia GO:0002931 14 0.176
positive regulation of apoptotic signaling pathway GO:2001235 95 0.175
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.174
regulation of calcium ion transmembrane transporter activity GO:1901019 20 0.174
mapk cascade GO:0000165 281 0.174
positive regulation of meiosis GO:0045836 14 0.173
meiotic nuclear division GO:0007126 115 0.172
dense core granule biogenesis GO:0061110 1 0.171
regulation of cellular response to growth factor stimulus GO:0090287 82 0.171
regulation of receptor activity GO:0010469 41 0.170
wound healing GO:0042060 157 0.169
i kappab kinase nf kappab signaling GO:0007249 85 0.168
cellular response to molecule of bacterial origin GO:0071219 83 0.168
positive regulation of protein phosphorylation GO:0001934 242 0.167
regulation of cellular ketone metabolic process GO:0010565 66 0.166
microtubule based process GO:0007017 236 0.165
t cell proliferation GO:0042098 120 0.164
protein autophosphorylation GO:0046777 61 0.163
divalent inorganic cation transport GO:0072511 178 0.163
camera type eye development GO:0043010 266 0.161
leukocyte differentiation GO:0002521 342 0.160
ventricular cardiac myofibril assembly GO:0055005 3 0.160
regulation of sodium ion transport GO:0002028 29 0.160
positive regulation of protein modification process GO:0031401 299 0.160
adaptive immune response GO:0002250 155 0.159
carbohydrate metabolic process GO:0005975 230 0.157
long term memory GO:0007616 15 0.155
protein polymerization GO:0051258 57 0.154
regulation of blood coagulation GO:0030193 28 0.153
negative regulation of molecular function GO:0044092 258 0.152
Human
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.152
regulation of transporter activity GO:0032409 57 0.151
Human
regulation of actin polymerization or depolymerization GO:0008064 45 0.151
membrane organization GO:0061024 245 0.150
positive regulation of meiotic cell cycle GO:0051446 15 0.150
regulation of cell division GO:0051302 76 0.150
mitochondrial calcium ion homeostasis GO:0051560 7 0.149
myotube cell development GO:0014904 60 0.148
Zebrafish
cellular protein complex assembly GO:0043623 116 0.148
carbohydrate derivative catabolic process GO:1901136 231 0.145
leukocyte activation involved in immune response GO:0002366 126 0.144
regulation of synaptic plasticity GO:0048167 87 0.144
relaxation of muscle GO:0090075 18 0.144
regulation of actin filament polymerization GO:0030833 38 0.144
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.143
nucleoside catabolic process GO:0009164 206 0.143
positive regulation of schwann cell proliferation GO:0010625 1 0.143
positive regulation of interleukin 13 secretion GO:2000667 1 0.142
induction of positive chemotaxis GO:0050930 7 0.142
positive regulation of synaptic transmission gabaergic GO:0032230 8 0.142
release of sequestered calcium ion into cytosol GO:0051209 42 0.141
regulation of atp metabolic process GO:1903578 17 0.140
microtubule cytoskeleton organization GO:0000226 157 0.140
multi organism behavior GO:0051705 62 0.139
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.138
skin development GO:0043588 220 0.136
t helper 2 cell activation GO:0035712 2 0.135
response to metal ion GO:0010038 47 0.133
response to lipopolysaccharide GO:0032496 128 0.132
cellular divalent inorganic cation homeostasis GO:0072503 127 0.132
protein localization to organelle GO:0033365 185 0.132
regulation of intracellular transport GO:0032386 159 0.131
cellular homeostasis GO:0019725 240 0.129
regulation of purine nucleotide catabolic process GO:0033121 122 0.129
positive regulation of apoptotic process GO:0043065 217 0.128
cellular nitrogen compound catabolic process GO:0044270 280 0.127
regionalization GO:0003002 337 0.127
regulation of cellular component size GO:0032535 121 0.127
cellular protein catabolic process GO:0044257 155 0.127
response to insulin GO:0032868 100 0.126
maintenance of location GO:0051235 89 0.126
regulation of cell activation GO:0050865 289 0.125
regulation of membrane potential GO:0042391 192 0.124
Human
multi multicellular organism process GO:0044706 109 0.123
regulation of homotypic cell cell adhesion GO:0034110 13 0.123
positive regulation of protein targeting to membrane GO:0090314 7 0.123
transmembrane transport GO:0055085 412 0.122
Human
ribonucleoside monophosphate metabolic process GO:0009161 80 0.122
carbohydrate transport GO:0008643 62 0.121
response to alcohol GO:0097305 48 0.121
peptidyl tyrosine modification GO:0018212 145 0.121
regulation of cell cycle GO:0051726 281 0.120
regulation of secretion by cell GO:1903530 249 0.120
purine nucleoside triphosphate catabolic process GO:0009146 203 0.119
axonal fasciculation GO:0007413 15 0.118
neutrophil chemotaxis GO:0030593 36 0.117
cardiac ventricle morphogenesis GO:0003208 50 0.117
sodium ion transport GO:0006814 73 0.117
amine metabolic process GO:0009308 45 0.115
negative regulation of apoptotic signaling pathway GO:2001234 104 0.114
gtp catabolic process GO:0006184 143 0.114
regulation of leukocyte proliferation GO:0070663 121 0.113
positive regulation of lymphocyte activation GO:0051251 140 0.113
apoptotic mitochondrial changes GO:0008637 48 0.113
mitotic cell cycle process GO:1903047 159 0.113
Worm
metal ion homeostasis GO:0055065 189 0.112
neurotransmitter transport GO:0006836 76 0.112
regulation of atpase activity GO:0043462 9 0.111
peptidyl serine phosphorylation GO:0018105 74 0.111
skeletal muscle myosin thick filament assembly GO:0030241 1 0.111
cellular ketone metabolic process GO:0042180 84 0.111
cellular response to cytokine stimulus GO:0071345 189 0.111
cytosolic calcium ion homeostasis GO:0051480 70 0.110
response to organic cyclic compound GO:0014070 198 0.110
calcium mediated signaling GO:0019722 46 0.110
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.109
cellular response to lipid GO:0071396 145 0.109
cellular response to carbohydrate stimulus GO:0071322 50 0.108
cellular response to insulin stimulus GO:0032869 78 0.108
atp metabolic process GO:0046034 75 0.108
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 12 0.108
purine containing compound metabolic process GO:0072521 311 0.108
anatomical structure homeostasis GO:0060249 145 0.106
peptidyl amino acid modification GO:0018193 336 0.106
inorganic ion transmembrane transport GO:0098660 234 0.103
Human
regulation of transmembrane transport GO:0034762 128 0.103
Human
positive regulation of keratinocyte differentiation GO:0045618 3 0.103
glucose transport GO:0015758 56 0.103
nucleoside metabolic process GO:0009116 246 0.101
regulation of ral gtpase activity GO:0032315 4 0.100
maternal determination of anterior posterior axis embryo GO:0008358 2 0.100
muscle cell apoptotic process GO:0010657 18 0.098
multicellular organismal reproductive behavior GO:0033057 23 0.098
divalent metal ion transport GO:0070838 172 0.097
protein processing GO:0016485 163 0.096
regulation of synaptic transmission gabaergic GO:0032228 17 0.096
innate immune response GO:0045087 157 0.094
regulation of skeletal muscle fiber development GO:0048742 36 0.094
negative regulation of map kinase activity GO:0043407 34 0.094
multicellular organismal response to stress GO:0033555 62 0.093
positive regulation of heart contraction GO:0045823 14 0.093
regulation of cardiac muscle contraction GO:0055117 21 0.093
regulation of cellular amine metabolic process GO:0033238 20 0.093
t cell activation GO:0042110 289 0.092
regulation of epidermal cell differentiation GO:0045604 21 0.092
positive regulation of ion transmembrane transporter activity GO:0032414 15 0.092
Human
positive regulation of chemotaxis GO:0050921 38 0.091
positive regulation of cell cycle GO:0045787 92 0.091
purine nucleoside monophosphate metabolic process GO:0009126 81 0.091
cellular response to organonitrogen compound GO:0071417 145 0.091
regulation of lymphocyte proliferation GO:0050670 117 0.091
male gamete generation GO:0048232 285 0.090
positive regulation of cell motility GO:2000147 116 0.090
positive regulation of interleukin 10 secretion GO:2001181 1 0.089
activation of ral gtpase activity GO:0032859 3 0.088
positive regulation of cellular amine metabolic process GO:0033240 5 0.087
regulation of protein serine threonine kinase activity GO:0071900 157 0.086
positive regulation of interleukin 5 secretion GO:2000664 1 0.086
small gtpase mediated signal transduction GO:0007264 97 0.086
positive regulation of glial cell proliferation GO:0060252 4 0.086
blood vessel morphogenesis GO:0048514 285 0.086
cardiac muscle fiber development GO:0048739 4 0.086
regulation of feeding behavior GO:0060259 3 0.085
regulation of protein targeting GO:1903533 61 0.084
purine ribonucleoside metabolic process GO:0046128 241 0.084
regulation of transferase activity GO:0051338 263 0.083
positive regulation of behavior GO:0048520 40 0.083
positive regulation of protein kinase activity GO:0045860 144 0.083
positive regulation of angiogenesis GO:0045766 46 0.083
axon ensheathment GO:0008366 76 0.083
regulation of wound healing GO:0061041 40 0.083
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.083
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.082
regulation of lipid catabolic process GO:0050994 15 0.082
glucose metabolic process GO:0006006 92 0.082
feeding behavior GO:0007631 62 0.082
response to hypoxia GO:0001666 58 0.082
regulation of purine nucleotide metabolic process GO:1900542 169 0.081
negative regulation of cellular amine metabolic process GO:0033239 1 0.081
positive regulation of striated muscle cell apoptotic process GO:0010663 3 0.080
nucleotide metabolic process GO:0009117 332 0.080
positive regulation of actin filament polymerization GO:0030838 26 0.080
purine ribonucleoside catabolic process GO:0046130 205 0.079
positive regulation of cytokine production GO:0001819 174 0.079
nucleoside monophosphate catabolic process GO:0009125 59 0.079
male courtship behavior GO:0008049 2 0.078
regulation of nuclear division GO:0051783 56 0.078
positive regulation of cell division GO:0051781 31 0.077
regulation of chemotaxis GO:0050920 53 0.077
positive regulation of nuclear division GO:0051785 27 0.076
establishment or maintenance of cell polarity GO:0007163 86 0.076
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.076
endocytosis GO:0006897 168 0.075
Mouse
cell recognition GO:0008037 83 0.075
cellular response to acid chemical GO:0071229 68 0.074
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.074
divalent inorganic cation homeostasis GO:0072507 138 0.074
protein modification by small protein conjugation or removal GO:0070647 207 0.072
cardiac chamber morphogenesis GO:0003206 93 0.072
interleukin 5 secretion GO:0072603 2 0.071
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.071
bone development GO:0060348 120 0.071
ubiquitin dependent protein catabolic process GO:0006511 129 0.071
regulation of ion homeostasis GO:2000021 64 0.070
t helper 2 cell cytokine production GO:0035745 4 0.070
response to radiation GO:0009314 165 0.070
regulation of platelet activation GO:0010543 17 0.070
peptidyl threonine modification GO:0018210 31 0.069
regulation of protein complex assembly GO:0043254 83 0.069
positive regulation of sodium ion transport GO:0010765 13 0.069
cartilage development GO:0051216 140 0.069
potassium ion transport GO:0006813 52 0.068
Human
regulation of filopodium assembly GO:0051489 13 0.068
gonad development GO:0008406 141 0.068
regulation of neuron projection development GO:0010975 169 0.067
keratinocyte differentiation GO:0030216 48 0.067
negative regulation of cellular component organization GO:0051129 194 0.066
associative learning GO:0008306 61 0.066
positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 5 0.066
modification dependent macromolecule catabolic process GO:0043632 133 0.066
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.065
mesoderm development GO:0007498 100 0.065
positive regulation of calcium ion transmembrane transporter activity GO:1901021 8 0.065
production of molecular mediator of immune response GO:0002440 103 0.065
chromatin organization GO:0006325 206 0.064
ossification GO:0001503 216 0.064
antigen receptor mediated signaling pathway GO:0050851 64 0.064
cellular modified amino acid biosynthetic process GO:0042398 12 0.064
positive regulation of striated muscle contraction GO:0045989 3 0.064
positive regulation of cardiac muscle contraction GO:0060452 2 0.063
striated muscle hypertrophy GO:0014897 24 0.063
cytokinetic process GO:0032506 2 0.063
regulation of transposition GO:0010528 2 0.062
regulation of voltage gated calcium channel activity GO:1901385 4 0.062
nucleoside monophosphate metabolic process GO:0009123 85 0.062
positive regulation of voltage gated calcium channel activity GO:1901387 2 0.061
ribonucleoside triphosphate metabolic process GO:0009199 220 0.061
cellular response to hormone stimulus GO:0032870 150 0.061
mitochondrial membrane organization GO:0007006 26 0.061
response to reactive oxygen species GO:0000302 56 0.061
positive regulation of t helper 2 cell activation GO:2000570 2 0.060
proteasomal protein catabolic process GO:0010498 98 0.060
cellular glucan metabolic process GO:0006073 32 0.060
ral protein signal transduction GO:0032484 2 0.060
positive regulation of cell cycle process GO:0090068 61 0.060
positive regulation of secretion GO:0051047 130 0.059
modification dependent protein catabolic process GO:0019941 133 0.059
long term synaptic potentiation GO:0060291 25 0.059
leukocyte proliferation GO:0070661 172 0.058
positive regulation of interleukin 13 production GO:0032736 4 0.058
positive regulation of kinase activity GO:0033674 155 0.058
generation of precursor metabolites and energy GO:0006091 103 0.057
cell adhesion GO:0007155 329 0.057
Human
positive regulation of nucleotide metabolic process GO:0045981 114 0.057
regulation of reproductive process GO:2000241 66 0.057
negative regulation of protein phosphorylation GO:0001933 126 0.057
positive regulation of insulin secretion GO:0032024 26 0.056
positive regulation of defense response GO:0031349 124 0.056
regulation of muscle tissue development GO:1901861 97 0.055
neuromuscular process GO:0050905 99 0.055
positive regulation of mapk cascade GO:0043410 170 0.055
regulation of cell motility GO:2000145 236 0.055
organelle fusion GO:0048284 28 0.054
placenta blood vessel development GO:0060674 31 0.054
cellular amine metabolic process GO:0044106 44 0.053
regulation of myeloid cell differentiation GO:0045637 96 0.053
regulation of cellular protein catabolic process GO:1903362 61 0.053
response to steroid hormone GO:0048545 56 0.053
learning or memory GO:0007611 148 0.052
cellular response to epidermal growth factor stimulus GO:0071364 4 0.052
macrophage derived foam cell differentiation GO:0010742 6 0.052
inhibitory g protein coupled receptor phosphorylation GO:0002030 1 0.052
platelet activation GO:0030168 40 0.052
gtp metabolic process GO:0046039 144 0.052
smooth muscle contraction GO:0006939 44 0.051
cellular response to biotic stimulus GO:0071216 92 0.051
organonitrogen compound catabolic process GO:1901565 264 0.051
detection of external stimulus GO:0009581 61 0.051
regulation of platelet aggregation GO:0090330 10 0.050
endodermal cell fate specification GO:0001714 4 0.050
olfactory learning GO:0008355 2 0.050
positive regulation of intracellular protein transport GO:0090316 42 0.050
myeloid cell differentiation GO:0030099 233 0.050
regulation of cytoplasmic transport GO:1903649 112 0.050
mrna metabolic process GO:0016071 84 0.049
regulation of ral protein signal transduction GO:0032485 4 0.049
regulation of mitochondrial membrane permeability GO:0046902 17 0.049
female gamete generation GO:0007292 74 0.049
regulation of meiotic cell cycle GO:0051445 34 0.049
regulation of cell adhesion GO:0030155 154 0.048
negative regulation of cell proliferation GO:0008285 296 0.048
positive regulation of muscle cell apoptotic process GO:0010661 6 0.048
interleukin 13 secretion GO:0072611 2 0.048
schwann cell proliferation GO:0014010 2 0.047
immune effector process GO:0002252 321 0.047
multicellular organismal signaling GO:0035637 91 0.047
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.047
lymphocyte mediated immunity GO:0002449 139 0.047
lymphocyte proliferation GO:0046651 164 0.047
regulation of protein catabolic process GO:0042176 108 0.047
positive regulation of t cell activation GO:0050870 101 0.047
regulation of homeostatic process GO:0032844 182 0.047

Actn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 1.000
disease of anatomical entity DOID:7 0 1.000
musculoskeletal system disease DOID:17 0 1.000
muscle tissue disease DOID:66 0 0.999
myopathy DOID:423 0 0.995
heart disease DOID:114 0 0.977
cardiomyopathy DOID:0050700 0 0.977
cardiovascular system disease DOID:1287 0 0.977
intrinsic cardiomyopathy DOID:0060036 0 0.973
dilated cardiomyopathy DOID:12930 0 0.871
hypertrophic cardiomyopathy DOID:11984 0 0.775
muscular dystrophy DOID:9884 0 0.432
distal arthrogryposis DOID:0050646 0 0.352
nervous system disease DOID:863 0 0.139