Mus musculus

34 known processes

Adam15

a disintegrin and metallopeptidase domain 15 (metargidin)

(Aliases: metargidin,MDC15)

Adam15 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.891
Mouse
prevention of polyspermy GO:0060468 4 0.880
Mouse
fibronectin dependent thymocyte migration GO:0072681 1 0.845
Mouse
extracellular matrix dependent thymocyte migration GO:0072680 1 0.771
Mouse
thymocyte migration GO:0072679 2 0.675
Mouse
regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000307 1 0.670
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.667
regulation of fibronectin dependent thymocyte migration GO:2000413 1 0.615
Mouse
regulation of thymocyte migration GO:2000410 2 0.609
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.492
Mouse
positive regulation of eosinophil migration GO:2000418 2 0.484
Mouse
regulation of membrane protein ectodomain proteolysis GO:0051043 3 0.469
Mouse
regulation of cell motility GO:2000145 236 0.427
Human Mouse
regulation of t cell activation GO:0050863 170 0.415
Mouse
positive regulation of mapk cascade GO:0043410 170 0.410
Mouse
myeloid cell homeostasis GO:0002262 114 0.353
Mouse
response to organic cyclic compound GO:0014070 198 0.342
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.318
Mouse
locomotory behavior GO:0007626 195 0.308
Mouse
lymphocyte differentiation GO:0030098 242 0.303
Mouse
mapk cascade GO:0000165 281 0.290
Mouse
cation transport GO:0006812 399 0.286
learning or memory GO:0007611 148 0.284
Mouse
t cell activation GO:0042110 289 0.271
Mouse
germinal center formation GO:0002467 16 0.263
Mouse
regulation of t cell differentiation GO:0045580 83 0.260
Mouse
regulation of eosinophil migration GO:2000416 2 0.259
Mouse
striated muscle tissue development GO:0014706 293 0.254
eosinophil migration GO:0072677 3 0.250
Mouse
t cell differentiation GO:0030217 174 0.248
Mouse
positive regulation of kinase activity GO:0033674 155 0.247
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.247
muscle tissue development GO:0060537 308 0.243
angiogenesis GO:0001525 201 0.234
Mouse
cellular amino acid metabolic process GO:0006520 103 0.233
membrane protein proteolysis GO:0033619 10 0.223
Mouse
regulation of lymphocyte differentiation GO:0045619 107 0.223
Mouse
transmembrane transport GO:0055085 412 0.222
transmission of nerve impulse GO:0019226 76 0.219
Mouse
glycoprotein biosynthetic process GO:0009101 89 0.207
ion transmembrane transport GO:0034220 361 0.207
b cell activation GO:0042113 161 0.204
Mouse
cellular response to growth factor stimulus GO:0071363 197 0.203
Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.198
Mouse
positive regulation of homeostatic process GO:0032846 64 0.189
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.189
Mouse
cognition GO:0050890 149 0.186
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.185
Mouse
leukocyte migration GO:0050900 124 0.182
Mouse
response to light stimulus GO:0009416 135 0.180
Mouse
regulation of cell migration GO:0030334 219 0.179
Human Mouse
myelination in peripheral nervous system GO:0022011 19 0.178
Mouse
ribose phosphate metabolic process GO:0019693 291 0.178
schwann cell development GO:0014044 22 0.178
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.175
Mouse
positive regulation of protein modification process GO:0031401 299 0.172
Mouse
protein localization to membrane GO:0072657 108 0.172
pma inducible membrane protein ectodomain proteolysis GO:0051088 1 0.170
Mouse
stem cell differentiation GO:0048863 268 0.167
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.163
Mouse
regulation of protein catabolic process GO:0042176 108 0.162
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.162
Mouse
cation transmembrane transport GO:0098655 266 0.161
macromolecule glycosylation GO:0043413 55 0.157
leukocyte differentiation GO:0002521 342 0.154
Mouse
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.151
Mouse
inflammatory response GO:0006954 244 0.151
Mouse
granulocyte migration GO:0097530 43 0.148
Mouse
regulation of cellular amine metabolic process GO:0033238 20 0.147
positive regulation of bone resorption GO:0045780 13 0.145
Mouse
purine containing compound metabolic process GO:0072521 311 0.144
regulation of transferase activity GO:0051338 263 0.142
Mouse
inorganic cation transmembrane transport GO:0098662 207 0.142
cardiac muscle tissue development GO:0048738 130 0.141
positive regulation of bone remodeling GO:0046852 13 0.141
Mouse
anion transport GO:0006820 177 0.140
response to growth factor GO:0070848 198 0.137
Mouse
glycoprotein metabolic process GO:0009100 116 0.137
positive regulation of t cell differentiation GO:0045582 52 0.132
Mouse
protein kinase b signaling GO:0043491 74 0.130
Mouse
regulation of cell activation GO:0050865 289 0.129
Mouse
positive regulation of fibronectin dependent thymocyte migration GO:2000415 1 0.129
Mouse
regulation of lymphocyte activation GO:0051249 240 0.128
Mouse
multicellular organismal signaling GO:0035637 91 0.125
Mouse
establishment of vesicle localization GO:0051650 81 0.124
anatomical structure homeostasis GO:0060249 145 0.124
Mouse
spleen development GO:0048536 39 0.121
Mouse
visual behavior GO:0007632 45 0.121
Mouse
response to radiation GO:0009314 165 0.120
Mouse
regulation of protein kinase activity GO:0045859 232 0.120
Mouse
positive regulation of nf kappab transcription factor activity GO:0051092 30 0.119
Mouse
divalent inorganic cation transport GO:0072511 178 0.119
positive regulation of lymphocyte activation GO:0051251 140 0.118
Mouse
calcium ion transport GO:0006816 159 0.117
response to peptide GO:1901652 136 0.117
t cell differentiation in thymus GO:0033077 77 0.116
Mouse
positive regulation of t cell activation GO:0050870 101 0.115
Mouse
regulation of kinase activity GO:0043549 249 0.112
Mouse
divalent metal ion transport GO:0070838 172 0.109
neuronal action potential GO:0019228 54 0.108
Mouse
positive regulation of cell migration GO:0030335 109 0.108
Mouse
regulation of multi organism process GO:0043900 111 0.107
Mouse
nucleobase containing small molecule metabolic process GO:0055086 352 0.107
membrane organization GO:0061024 245 0.105
cellular amine metabolic process GO:0044106 44 0.102
regulation of ion transport GO:0043269 215 0.101
chemotaxis GO:0006935 247 0.101
Mouse
skeletal system morphogenesis GO:0048705 203 0.100
neuron apoptotic process GO:0051402 142 0.100
Mouse
positive regulation of inflammatory response GO:0050729 47 0.099
Mouse
activation of mapk activity GO:0000187 59 0.099
Mouse
positive regulation of cell motility GO:2000147 116 0.098
Mouse
multicellular organismal homeostasis GO:0048871 164 0.097
Mouse
myeloid cell apoptotic process GO:0033028 22 0.096
Mouse
positive regulation of tissue remodeling GO:0034105 19 0.095
Mouse
regulation of intracellular transport GO:0032386 159 0.093
activation of innate immune response GO:0002218 56 0.093
Mouse
positive regulation of cell death GO:0010942 224 0.093
Mouse
regulation of myotube differentiation GO:0010830 62 0.092
cellular chemical homeostasis GO:0055082 215 0.092
establishment of protein localization to membrane GO:0090150 54 0.091
small gtpase mediated signal transduction GO:0007264 97 0.090
regulation of membrane potential GO:0042391 192 0.090
Mouse
myelination GO:0042552 74 0.089
Mouse
positive regulation of apoptotic process GO:0043065 217 0.087
Mouse
cell adhesion GO:0007155 329 0.086
Human Mouse
nucleotide metabolic process GO:0009117 332 0.086
binding of sperm to zona pellucida GO:0007339 34 0.086
Mouse
inorganic ion transmembrane transport GO:0098660 234 0.086
regulation of neuron apoptotic process GO:0043523 122 0.084
Mouse
synaptic vesicle transport GO:0048489 57 0.083
glial cell development GO:0021782 54 0.083
Mouse
positive regulation of tumor necrosis factor ligand superfamily member 11 production GO:2000309 1 0.083
Mouse
visual learning GO:0008542 44 0.083
Mouse
cellular carbohydrate metabolic process GO:0044262 119 0.083
immune response activating signal transduction GO:0002757 116 0.082
Mouse
cell cell recognition GO:0009988 44 0.081
Mouse
actin cytoskeleton organization GO:0030036 220 0.081
organic anion transport GO:0015711 137 0.080
sodium ion transport GO:0006814 73 0.080
aromatic compound catabolic process GO:0019439 286 0.079
organophosphate biosynthetic process GO:0090407 122 0.079
activation of immune response GO:0002253 138 0.078
Mouse
macromolecule catabolic process GO:0009057 281 0.077
Mouse
carbohydrate biosynthetic process GO:0016051 74 0.077
response to peptide hormone GO:0043434 127 0.077
positive regulation of cell adhesion GO:0045785 80 0.076
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.076
guanosine containing compound metabolic process GO:1901068 144 0.076
carbohydrate metabolic process GO:0005975 230 0.076
cellular metal ion homeostasis GO:0006875 151 0.076
blood circulation GO:0008015 195 0.075
single fertilization GO:0007338 82 0.075
Mouse
cell junction organization GO:0034330 77 0.074
action potential GO:0001508 78 0.074
Mouse
regulation of response to wounding GO:1903034 189 0.074
Mouse
positive regulation of leukocyte differentiation GO:1902107 86 0.074
Mouse
positive regulation of cellular catabolic process GO:0031331 148 0.074
Mouse
positive regulation of lymphocyte differentiation GO:0045621 61 0.072
Mouse
bone development GO:0060348 120 0.072
schwann cell differentiation GO:0014037 26 0.071
Mouse
leukocyte chemotaxis GO:0030595 69 0.071
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.071
Mouse
cellular ion homeostasis GO:0006873 165 0.070
regulation of ion transmembrane transporter activity GO:0032412 54 0.070
mucopolysaccharide metabolic process GO:1903510 25 0.070
regulation of protein serine threonine kinase activity GO:0071900 157 0.070
Mouse
skeletal system development GO:0001501 356 0.069
adult locomotory behavior GO:0008344 91 0.068
Mouse
oxidation reduction process GO:0055114 342 0.067
positive regulation of intracellular transport GO:0032388 70 0.067
regulation of protein localization GO:0032880 231 0.067
associative learning GO:0008306 61 0.066
Mouse
regulation of mapk cascade GO:0043408 248 0.066
Mouse
muscle contraction GO:0006936 101 0.066
regulation of homeostatic process GO:0032844 182 0.065
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.065
endomembrane system organization GO:0010256 147 0.065
single organism cell adhesion GO:0098602 156 0.063
Mouse
developmental maturation GO:0021700 193 0.063
learning GO:0007612 98 0.063
Mouse
regulation of cellular catabolic process GO:0031329 242 0.063
Mouse
leukocyte homeostasis GO:0001776 79 0.063
Mouse
protein catabolic process GO:0030163 221 0.063
Mouse
cellular response to insulin stimulus GO:0032869 78 0.062
negative regulation of leukocyte differentiation GO:1902106 51 0.062
myeloid cell differentiation GO:0030099 233 0.061
axonogenesis GO:0007409 274 0.061
mesenchymal cell development GO:0014031 93 0.061
blood vessel morphogenesis GO:0048514 285 0.060
Mouse
plasma membrane organization GO:0007009 90 0.060
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.059
Mouse
glycosyl compound metabolic process GO:1901657 246 0.059
cell chemotaxis GO:0060326 81 0.059
Mouse
forebrain development GO:0030900 302 0.059
organic acid transport GO:0015849 101 0.059
regulation of secretion by cell GO:1903530 249 0.059
leukocyte migration involved in inflammatory response GO:0002523 7 0.058
Mouse
immune response regulating signaling pathway GO:0002764 125 0.058
Mouse
regulation of ion transmembrane transport GO:0034765 119 0.058
chondrocyte differentiation GO:0002062 72 0.058
purine ribonucleotide metabolic process GO:0009150 290 0.058
gland development GO:0048732 330 0.057
limb development GO:0060173 166 0.057
adaptive immune response GO:0002250 155 0.057
Mouse
membrane protein ectodomain proteolysis GO:0006509 7 0.056
Mouse
regulation of tissue remodeling GO:0034103 38 0.056
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.056
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.055
Mouse
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.055
response to lipopolysaccharide GO:0032496 128 0.055
regulation of transmembrane transport GO:0034762 128 0.054
protein glycosylation GO:0006486 55 0.053
positive regulation of response to wounding GO:1903036 66 0.053
Mouse
cell substrate adhesion GO:0031589 130 0.052
Human
cytosolic calcium ion transport GO:0060401 48 0.052
acute inflammatory response GO:0002526 41 0.052
Mouse
embryonic organ morphogenesis GO:0048562 276 0.052
carboxylic acid transport GO:0046942 100 0.052
lung development GO:0030324 164 0.051
peptidyl amino acid modification GO:0018193 336 0.051
positive regulation of nervous system development GO:0051962 221 0.051
egg activation GO:0007343 7 0.051
Mouse
negative regulation of neuron apoptotic process GO:0043524 92 0.051
Mouse
response to drug GO:0042493 75 0.051
Mouse
neuron death GO:0070997 154 0.050
Mouse
regulation of bone remodeling GO:0046850 28 0.050
Mouse
regulation of cytokine production GO:0001817 266 0.050
Mouse
regulation of transporter activity GO:0032409 57 0.049
innate immune response GO:0045087 157 0.049
Human Mouse
axon ensheathment GO:0008366 76 0.049
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.049
positive regulation of secretion GO:0051047 130 0.048
single organismal cell cell adhesion GO:0016337 131 0.048
Mouse
homeostasis of number of cells GO:0048872 210 0.048
Mouse
innate immune response activating signal transduction GO:0002758 50 0.047
Mouse
amine metabolic process GO:0009308 45 0.047
leukocyte apoptotic process GO:0071887 71 0.047
Mouse
positive regulation of proteolysis GO:0045862 85 0.047
Mouse
positive regulation of secretion by cell GO:1903532 114 0.046
male gamete generation GO:0048232 285 0.046
synaptic transmission GO:0007268 329 0.046
gtp catabolic process GO:0006184 143 0.046
purine nucleotide metabolic process GO:0006163 302 0.045
regulation of mast cell apoptotic process GO:0033025 5 0.045
Mouse
calcium ion transmembrane transport GO:0070588 85 0.045
acylglycerol metabolic process GO:0006639 55 0.045
regulation of t cell differentiation in thymus GO:0033081 24 0.045
Mouse
response to extracellular stimulus GO:0009991 127 0.044
cardiocyte differentiation GO:0035051 87 0.044
maintenance of location GO:0051235 89 0.044
cellular extravasation GO:0045123 17 0.044
Mouse
cellular ketone metabolic process GO:0042180 84 0.044
renal system development GO:0072001 225 0.044
regulation of map kinase activity GO:0043405 120 0.043
Mouse
striated muscle contraction GO:0006941 45 0.043
b cell differentiation GO:0030183 78 0.043
Mouse
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.043
Mouse
ensheathment of neurons GO:0007272 76 0.043
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.043
cd4 positive alpha beta t cell activation GO:0035710 45 0.043
positive regulation of transferase activity GO:0051347 167 0.043
Mouse
sensory perception GO:0007600 245 0.043
glycosylation GO:0070085 62 0.042
positive regulation of protein kinase b signaling GO:0051897 32 0.042
Mouse
circulatory system process GO:0003013 197 0.042
peptide transport GO:0015833 133 0.042
regulation of protein kinase b signaling GO:0051896 56 0.042
Mouse
response to inorganic substance GO:0010035 96 0.042
regulation of cytoskeleton organization GO:0051493 122 0.041
lipid transport GO:0006869 98 0.041
peptidyl serine modification GO:0018209 83 0.041
sensory perception of chemical stimulus GO:0007606 51 0.040
inner ear receptor cell development GO:0060119 39 0.040
regulation of apoptotic signaling pathway GO:2001233 197 0.040
positive regulation of protein catabolic process GO:0045732 60 0.040
Mouse
urogenital system development GO:0001655 261 0.040
male gonad development GO:0008584 88 0.039
positive regulation of programmed cell death GO:0043068 218 0.039
Mouse
peptidyl serine phosphorylation GO:0018105 74 0.039
cellular lipid metabolic process GO:0044255 323 0.039
nucleoside phosphate biosynthetic process GO:1901293 79 0.038
limb morphogenesis GO:0035108 149 0.038
bone morphogenesis GO:0060349 78 0.038
regulation of feeding behavior GO:0060259 3 0.038
tumor necrosis factor ligand superfamily member 11 production GO:0072535 1 0.038
Mouse
nephron development GO:0072006 109 0.037
organonitrogen compound biosynthetic process GO:1901566 192 0.037
regulation of actin filament based process GO:0032970 99 0.037
intracellular protein transport GO:0006886 204 0.037
regulation of cellular response to stress GO:0080135 159 0.037
cation homeostasis GO:0055080 212 0.037
cell cell junction organization GO:0045216 72 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.037
regulation of muscle system process GO:0090257 80 0.036
regulation of cell projection organization GO:0031344 206 0.036
cellular response to hormone stimulus GO:0032870 150 0.036
camp metabolic process GO:0046058 40 0.036
endocytosis GO:0006897 168 0.036
regulation of proteolysis GO:0030162 164 0.036
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.036
polysaccharide biosynthetic process GO:0000271 20 0.036
response to transforming growth factor beta GO:0071559 88 0.035
Mouse
carbohydrate derivative catabolic process GO:1901136 231 0.035
neutral lipid metabolic process GO:0006638 57 0.035
skeletal muscle organ development GO:0060538 163 0.035
regulation of system process GO:0044057 200 0.035
lipid localization GO:0010876 126 0.035
glycerolipid metabolic process GO:0046486 122 0.035
sensory perception of smell GO:0007608 26 0.035
negative regulation of intracellular signal transduction GO:1902532 167 0.034
regulation of ossification GO:0030278 112 0.034
negative regulation of molecular function GO:0044092 258 0.034
Human
regulation of leukocyte apoptotic process GO:2000106 56 0.034
Mouse
ribonucleoside metabolic process GO:0009119 245 0.033
bone resorption GO:0045453 38 0.033
Mouse
establishment of synaptic vesicle localization GO:0097480 57 0.033
negative regulation of phosphorus metabolic process GO:0010563 184 0.032
regulation of secretion GO:0051046 274 0.032
male sex differentiation GO:0046661 109 0.032
nucleoside catabolic process GO:0009164 206 0.032
cellular component assembly involved in morphogenesis GO:0010927 139 0.032
circadian temperature homeostasis GO:0060086 2 0.032
t cell apoptotic process GO:0070231 39 0.032
Mouse
positive regulation of thymocyte apoptotic process GO:0070245 5 0.032
Mouse
sperm egg recognition GO:0035036 37 0.031
Mouse
aminoglycan metabolic process GO:0006022 34 0.031
ear development GO:0043583 200 0.031
cellular response to cytokine stimulus GO:0071345 189 0.031
myotube differentiation GO:0014902 105 0.031
purine nucleotide biosynthetic process GO:0006164 65 0.031
regulation of defense response GO:0031347 233 0.031
Mouse
regulation of organelle organization GO:0033043 289 0.031
sphingolipid metabolic process GO:0006665 45 0.031
filopodium assembly GO:0046847 19 0.030
epithelial cell development GO:0002064 159 0.030
nucleoside metabolic process GO:0009116 246 0.030
neutrophil migration GO:1990266 37 0.029
nitrogen compound transport GO:0071705 271 0.029
protein localization to plasma membrane GO:0072659 57 0.029
sulfur compound biosynthetic process GO:0044272 37 0.029
ras protein signal transduction GO:0007265 77 0.029
organophosphate catabolic process GO:0046434 232 0.029
positive regulation of acute inflammatory response GO:0002675 16 0.029
Mouse
positive regulation of defense response GO:0031349 124 0.029
Mouse
stem cell maintenance GO:0019827 130 0.028
regulation of vesicle mediated transport GO:0060627 139 0.028
ribonucleotide catabolic process GO:0009261 208 0.028
purine nucleoside metabolic process GO:0042278 241 0.028
positive regulation of cell development GO:0010720 237 0.028
ribonucleoside triphosphate metabolic process GO:0009199 220 0.028
carboxylic acid catabolic process GO:0046395 51 0.028
regulation of intracellular protein transport GO:0033157 82 0.028
glycosaminoglycan biosynthetic process GO:0006024 15 0.027
monocarboxylic acid transport GO:0015718 44 0.027
regulation of metal ion transport GO:0010959 106 0.027
lymphocyte apoptotic process GO:0070227 54 0.027
Mouse
regulation of lymphocyte apoptotic process GO:0070228 41 0.027
Mouse
nucleotide biosynthetic process GO:0009165 78 0.027
establishment of organelle localization GO:0051656 122 0.027
female sex differentiation GO:0046660 84 0.027
receptor mediated endocytosis GO:0006898 51 0.027
sulfur compound metabolic process GO:0006790 100 0.027
regulation of muscle tissue development GO:1901861 97 0.027
endochondral bone morphogenesis GO:0060350 50 0.027
regulation of neuron death GO:1901214 134 0.027
Mouse
small molecule catabolic process GO:0044282 71 0.027
sequestering of calcium ion GO:0051208 18 0.027
cytokine mediated signaling pathway GO:0019221 115 0.027
regulation of cell shape GO:0008360 39 0.026
ossification GO:0001503 216 0.026
heart process GO:0003015 94 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.026
cell fate commitment GO:0045165 210 0.026
positive regulation of calcium ion transport GO:0051928 27 0.026
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.026
Mouse
regulation of bone resorption GO:0045124 24 0.026
Mouse
cellular lipid catabolic process GO:0044242 52 0.026
cellular homeostasis GO:0019725 240 0.026
regulation of myeloid cell apoptotic process GO:0033032 19 0.026
Mouse
negative regulation of cell development GO:0010721 169 0.026
extracellular matrix organization GO:0030198 147 0.026
muscle system process GO:0003012 141 0.026
purine ribonucleotide catabolic process GO:0009154 208 0.026
response to organonitrogen compound GO:0010243 246 0.025
immune effector process GO:0002252 321 0.025
negative regulation of carbohydrate metabolic process GO:0045912 19 0.025
negative regulation of cell fate specification GO:0009996 4 0.025
chondrocyte development GO:0002063 24 0.025
positive regulation of glucose transport GO:0010828 16 0.025
basement membrane organization GO:0071711 8 0.025
respiratory tube development GO:0030323 167 0.025
development of primary male sexual characteristics GO:0046546 88 0.025
tissue homeostasis GO:0001894 115 0.025
Mouse
positive regulation of cytokine production GO:0001819 174 0.025
Mouse
organelle assembly GO:0070925 177 0.025
camp biosynthetic process GO:0006171 31 0.025
regulation of thymocyte apoptotic process GO:0070243 14 0.025
Mouse
appendage morphogenesis GO:0035107 149 0.025
mitochondrion organization GO:0007005 134 0.025
regulation of acute inflammatory response GO:0002673 27 0.025
Mouse
positive regulation of ion transport GO:0043270 65 0.025
regulation of inflammatory response GO:0050727 147 0.024
Mouse
cellular response to organonitrogen compound GO:0071417 145 0.024
fertilization GO:0009566 127 0.024
Mouse
regulation of skeletal muscle fiber development GO:0048742 36 0.024
ribonucleoside triphosphate catabolic process GO:0009203 199 0.024
establishment of protein localization to organelle GO:0072594 118 0.024
negative regulation of cellular component organization GO:0051129 194 0.024
organic acid catabolic process GO:0016054 51 0.024
regulation of calcium ion transport GO:0051924 69 0.024
negative regulation of phosphate metabolic process GO:0045936 184 0.024
purine ribonucleoside metabolic process GO:0046128 241 0.024
vesicle localization GO:0051648 86 0.023
development of primary female sexual characteristics GO:0046545 73 0.023
organelle localization GO:0051640 179 0.023
rhythmic process GO:0048511 174 0.023
protein maturation GO:0051604 176 0.023
development of primary sexual characteristics GO:0045137 143 0.023
polysaccharide metabolic process GO:0005976 39 0.023
synaptic vesicle localization GO:0097479 59 0.023
purine containing compound biosynthetic process GO:0072522 70 0.023
tissue remodeling GO:0048771 102 0.023
Mouse
regulation of calcium ion transmembrane transport GO:1903169 20 0.023
purine nucleoside catabolic process GO:0006152 205 0.023
regulation of nucleocytoplasmic transport GO:0046822 73 0.023
regulation of cell cycle GO:0051726 281 0.022
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.022
Mouse
sequestering of metal ion GO:0051238 19 0.022
skin development GO:0043588 220 0.022
neuron projection extension GO:1990138 64 0.022
energy derivation by oxidation of organic compounds GO:0015980 77 0.022
monosaccharide metabolic process GO:0005996 106 0.022
regulation of carbohydrate metabolic process GO:0006109 75 0.022
positive regulation of cell activation GO:0050867 158 0.022
Mouse
skeletal muscle fiber development GO:0048741 58 0.022
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.022
positive regulation of thymocyte migration GO:2000412 2 0.022
Mouse
cyclic nucleotide metabolic process GO:0009187 59 0.022
germ cell development GO:0007281 185 0.022
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.022
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.022
Mouse
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.021
Mouse
cartilage development GO:0051216 140 0.021
regulation of alpha beta t cell activation GO:0046634 53 0.021
response to nutrient levels GO:0031667 109 0.021
response to molecule of bacterial origin GO:0002237 143 0.021
lens development in camera type eye GO:0002088 62 0.021
cellular response to peptide GO:1901653 92 0.021
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.021
Mouse
positive regulation of growth GO:0045927 104 0.021
appendage development GO:0048736 166 0.021
epidermis development GO:0008544 187 0.021
adult behavior GO:0030534 135 0.021
Mouse
response to corticosteroid GO:0031960 20 0.021
Mouse
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.021
cellular phosphate ion homeostasis GO:0030643 2 0.021
regulation of cell substrate adhesion GO:0010810 73 0.021
Human
negative regulation of neuron projection development GO:0010977 50 0.021
epithelial cell migration GO:0010631 63 0.021
alpha beta t cell differentiation GO:0046632 69 0.020
rac protein signal transduction GO:0016601 13 0.020
regulation of myeloid cell differentiation GO:0045637 96 0.020
extracellular structure organization GO:0043062 148 0.020
amide transport GO:0042886 138 0.020
spermatid differentiation GO:0048515 115 0.020
regulation of rho gtpase activity GO:0032319 58 0.020
anion transmembrane transport GO:0098656 71 0.020
monocarboxylic acid metabolic process GO:0032787 191 0.020
negative regulation of cytokine production GO:0001818 84 0.020
positive regulation of leukocyte apoptotic process GO:2000108 21 0.020
Mouse
digestive system development GO:0055123 200 0.020
nucleoside triphosphate metabolic process GO:0009141 230 0.020
negative regulation of cell motility GO:2000146 61 0.020
Human
granulocyte chemotaxis GO:0071621 39 0.020
leukocyte activation involved in immune response GO:0002366 126 0.020
regulation of osteoclast differentiation GO:0045670 36 0.019
regulation of cell growth GO:0001558 91 0.019
Human
mast cell apoptotic process GO:0033024 5 0.019
Mouse
cell type specific apoptotic process GO:0097285 268 0.019
Mouse
negative regulation of fertilization GO:0060467 5 0.019
Mouse
mesenchymal cell differentiation GO:0048762 107 0.019
camera type eye development GO:0043010 266 0.019
fatty acid transmembrane transport GO:1902001 1 0.019
gtp metabolic process GO:0046039 144 0.019
lipid catabolic process GO:0016042 69 0.019
satellite cell activation involved in skeletal muscle regeneration GO:0014901 3 0.019

Adam15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 0 0.126
disease of anatomical entity DOID:7 0 0.126
musculoskeletal system disease DOID:17 0 0.126
nervous system disease DOID:863 0 0.086
disease of metabolism DOID:0014667 0 0.029
cardiovascular system disease DOID:1287 0 0.022
central nervous system disease DOID:331 0 0.021
retinal disease DOID:5679 0 0.019
retinal degeneration DOID:8466 0 0.019
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
eye disease DOID:5614 0 0.019