Mus musculus

82 known processes

Aifm1

apoptosis-inducing factor, mitochondrion-associated 1

(Aliases: Hq,mAIF,Pdcd8,MGC5706,AIF,AIFsh2)

Aifm1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular hyperosmotic salinity response GO:0071475 0 1.000
oxidation reduction process GO:0055114 342 0.798
cellular response to salt stress GO:0071472 1 0.777
mitochondrion organization GO:0007005 134 0.712
coenzyme metabolic process GO:0006732 52 0.506
mitochondrial respiratory chain complex assembly GO:0033108 2 0.418
mitochondrial translation GO:0032543 4 0.350
generation of precursor metabolites and energy GO:0006091 103 0.346
Fly
energy derivation by oxidation of organic compounds GO:0015980 77 0.326
Fly
cellular respiration GO:0045333 38 0.235
Fly
acetyl coa biosynthetic process GO:0006085 5 0.220
hyperosmotic salinity response GO:0042538 1 0.205
cellular hyperosmotic response GO:0071474 0 0.199
mitochondrial transport GO:0006839 36 0.148
glycosyl compound metabolic process GO:1901657 246 0.139
Fly
cofactor biosynthetic process GO:0051188 41 0.136
macromolecule catabolic process GO:0009057 281 0.133
acetyl coa biosynthetic process from pyruvate GO:0006086 3 0.132
regulation of membrane potential GO:0042391 192 0.129
regulation of peptidase activity GO:0052547 96 0.128
negative regulation of cellular response to oxidative stress GO:1900408 10 0.127
transmembrane transport GO:0055085 412 0.112
cellular amino acid metabolic process GO:0006520 103 0.110
purine nucleoside metabolic process GO:0042278 241 0.107
Fly
cellular ketone metabolic process GO:0042180 84 0.105
coenzyme biosynthetic process GO:0009108 23 0.103
translation GO:0006412 93 0.102
organic acid catabolic process GO:0016054 51 0.099
citrate metabolic process GO:0006101 3 0.098
monocarboxylic acid metabolic process GO:0032787 191 0.097
purine ribonucleotide metabolic process GO:0009150 290 0.095
Fly
small molecule catabolic process GO:0044282 71 0.094
cofactor metabolic process GO:0051186 80 0.093
response to oxygen radical GO:0000305 16 0.090
regulation of cellular ketone metabolic process GO:0010565 66 0.089
protein processing GO:0016485 163 0.087
cellular lipid metabolic process GO:0044255 323 0.085
thioester metabolic process GO:0035383 19 0.084
gland development GO:0048732 330 0.082
cellular nitrogen compound catabolic process GO:0044270 280 0.081
response to organic cyclic compound GO:0014070 198 0.078
multicellular organism growth GO:0035264 161 0.078
protein maturation GO:0051604 176 0.078
nucleoside phosphate metabolic process GO:0006753 338 0.075
Fly
nitrogen compound transport GO:0071705 271 0.075
apoptotic signaling pathway GO:0097190 306 0.074
negative regulation of apoptotic signaling pathway GO:2001234 104 0.071
neuron apoptotic process GO:0051402 142 0.071
negative regulation of immune system process GO:0002683 209 0.070
acyl coa biosynthetic process GO:0071616 7 0.069
endomembrane system organization GO:0010256 147 0.069
kidney development GO:0001822 213 0.067
multicellular organismal homeostasis GO:0048871 164 0.065
response to inorganic substance GO:0010035 96 0.064
regulation of cellular catabolic process GO:0031329 242 0.063
cristae formation GO:0042407 3 0.063
amine metabolic process GO:0009308 45 0.062
protein localization to organelle GO:0033365 185 0.059
myeloid cell differentiation GO:0030099 233 0.058
response to ionizing radiation GO:0010212 42 0.058
cellular response to oxidative stress GO:0034599 76 0.058
hyperosmotic response GO:0006972 4 0.056
response to oxidative stress GO:0006979 123 0.056
purine ribonucleoside metabolic process GO:0046128 241 0.056
Fly
response to steroid hormone GO:0048545 56 0.056
protein oxidation GO:0018158 2 0.056
cellular macromolecule catabolic process GO:0044265 206 0.055
organic cyclic compound catabolic process GO:1901361 295 0.054
regulation of cellular amino acid metabolic process GO:0006521 5 0.054
thioester biosynthetic process GO:0035384 7 0.053
male gamete generation GO:0048232 285 0.052
fatty acid oxidation GO:0019395 28 0.051
cellular protein complex assembly GO:0043623 116 0.050
reactive oxygen species metabolic process GO:0072593 84 0.049
organic hydroxy compound metabolic process GO:1901615 203 0.049
nucleobase containing small molecule metabolic process GO:0055086 352 0.048
Fly
spermatid development GO:0007286 108 0.048
response to reactive oxygen species GO:0000302 56 0.048
homeostasis of number of cells GO:0048872 210 0.047
cellular response to osmotic stress GO:0071470 7 0.046
cellular metal ion homeostasis GO:0006875 151 0.046
regulation of apoptotic signaling pathway GO:2001233 197 0.045
positive regulation of growth GO:0045927 104 0.044
vasodilation GO:0042311 28 0.043
membrane organization GO:0061024 245 0.043
negative regulation of molecular function GO:0044092 258 0.042
aromatic compound catabolic process GO:0019439 286 0.042
ion transmembrane transport GO:0034220 361 0.042
leukocyte differentiation GO:0002521 342 0.042
protein transmembrane transport GO:0071806 8 0.042
nucleoside monophosphate metabolic process GO:0009123 85 0.042
Fly
ribonucleotide metabolic process GO:0009259 291 0.041
Fly
inflammatory response GO:0006954 244 0.041
inner mitochondrial membrane organization GO:0007007 5 0.041
lipid biosynthetic process GO:0008610 179 0.040
liver development GO:0001889 66 0.040
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.039
Fly
cellular homeostasis GO:0019725 240 0.039
lipid oxidation GO:0034440 29 0.036
intrinsic apoptotic signaling pathway GO:0097193 132 0.036
cellular response to lipid GO:0071396 145 0.035
blood circulation GO:0008015 195 0.035
organonitrogen compound biosynthetic process GO:1901566 192 0.035
negative regulation of response to oxidative stress GO:1902883 10 0.035
ribose phosphate metabolic process GO:0019693 291 0.034
Fly
regulation of secretion by cell GO:1903530 249 0.034
spermatogenesis GO:0007283 284 0.034
heart process GO:0003015 94 0.034
response to organonitrogen compound GO:0010243 246 0.034
mitochondrial protein processing GO:0034982 5 0.034
protein targeting to mitochondrion GO:0006626 6 0.034
peptidyl amino acid modification GO:0018193 336 0.034
dna metabolic process GO:0006259 303 0.034
regulation of hydrolase activity GO:0051336 246 0.034
multicellular organismal aging GO:0010259 24 0.033
renal system development GO:0072001 225 0.033
epithelial tube morphogenesis GO:0060562 303 0.033
mitochondrion degradation GO:0000422 3 0.033
circulatory system process GO:0003013 197 0.033
small molecule biosynthetic process GO:0044283 132 0.033
cellular amine metabolic process GO:0044106 44 0.032
cation homeostasis GO:0055080 212 0.032
defecation GO:0030421 1 0.032
cellular aldehyde metabolic process GO:0006081 12 0.032
carnitine metabolic process GO:0009437 7 0.032
iron ion homeostasis GO:0055072 36 0.032
regulation of anatomical structure size GO:0090066 178 0.031
epithelial cell development GO:0002064 159 0.031
transition metal ion homeostasis GO:0055076 54 0.031
myeloid leukocyte differentiation GO:0002573 119 0.031
heart morphogenesis GO:0003007 178 0.031
nucleotide metabolic process GO:0009117 332 0.030
Fly
muscle system process GO:0003012 141 0.030
hepaticobiliary system development GO:0061008 67 0.030
atp metabolic process GO:0046034 75 0.030
Fly
protein oligomerization GO:0051259 67 0.030
engulfment of apoptotic cell GO:0043652 3 0.029
anatomical structure homeostasis GO:0060249 145 0.029
trna aminoacylation GO:0043039 1 0.029
carbohydrate metabolic process GO:0005975 230 0.029
regulation of response to oxidative stress GO:1902882 19 0.029
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.028
response to superoxide GO:0000303 16 0.028
mitochondrial membrane organization GO:0007006 26 0.028
endocytosis GO:0006897 168 0.028
spermatid differentiation GO:0048515 115 0.027
morphogenesis of embryonic epithelium GO:0016331 159 0.026
acylglycerol metabolic process GO:0006639 55 0.026
purine containing compound metabolic process GO:0072521 311 0.026
Fly
urogenital system development GO:0001655 261 0.026
alcohol metabolic process GO:0006066 116 0.026
metal ion homeostasis GO:0055065 189 0.025
protein homooligomerization GO:0051260 43 0.025
digestive tract morphogenesis GO:0048546 147 0.024
cellular response to oxygen radical GO:0071450 14 0.024
purine nucleotide metabolic process GO:0006163 302 0.024
Fly
regulation of cellular amine metabolic process GO:0033238 20 0.024
regulation of reactive oxygen species metabolic process GO:2000377 40 0.023
divalent metal ion transport GO:0070838 172 0.023
cell type specific apoptotic process GO:0097285 268 0.023
tricarboxylic acid metabolic process GO:0072350 5 0.022
phagocytosis GO:0006909 66 0.022
striated muscle tissue development GO:0014706 293 0.022
regulation of organelle organization GO:0033043 289 0.022
germ cell development GO:0007281 185 0.022
protein targeting GO:0006605 143 0.022
histone modification GO:0016570 159 0.022
positive regulation of hydrolase activity GO:0051345 148 0.022
amino acid betaine metabolic process GO:0006577 7 0.022
cation transport GO:0006812 399 0.022
development of primary male sexual characteristics GO:0046546 88 0.022
glycerolipid metabolic process GO:0046486 122 0.022
sulfur compound metabolic process GO:0006790 100 0.021
purine nucleoside triphosphate catabolic process GO:0009146 203 0.021
cellular response to dna damage stimulus GO:0006974 207 0.021
cellular response to cytokine stimulus GO:0071345 189 0.021
action potential GO:0001508 78 0.020
regulation of mitochondrial membrane potential GO:0051881 17 0.019
intracellular protein transport GO:0006886 204 0.019
cellular response to steroid hormone stimulus GO:0071383 33 0.019
epithelial cell proliferation GO:0050673 174 0.019
regulation of ion transport GO:0043269 215 0.019
acyl coa metabolic process GO:0006637 19 0.019
regulation of cell activation GO:0050865 289 0.019
microtubule based process GO:0007017 236 0.019
sulfur compound biosynthetic process GO:0044272 37 0.018
anion transport GO:0006820 177 0.018
sensory perception GO:0007600 245 0.018
fatty acid beta oxidation GO:0006635 16 0.018
regulation of inflammatory response GO:0050727 147 0.018
chemotaxis GO:0006935 247 0.018
regulation of blood pressure GO:0008217 93 0.018
negative regulation of oxidative stress induced cell death GO:1903202 9 0.018
maintenance of location GO:0051235 89 0.018
divalent inorganic cation transport GO:0072511 178 0.018
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
Fly
inorganic cation transmembrane transport GO:0098662 207 0.018
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.018
nuclear transport GO:0051169 139 0.018
purine nucleoside monophosphate metabolic process GO:0009126 81 0.017
Fly
adult behavior GO:0030534 135 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.017
organophosphate catabolic process GO:0046434 232 0.017
regulation of kinase activity GO:0043549 249 0.017
cellular response to superoxide GO:0071451 14 0.017
cellular response to hormone stimulus GO:0032870 150 0.017
glycerophospholipid metabolic process GO:0006650 71 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
pyridine containing compound metabolic process GO:0072524 14 0.017
reactive oxygen species biosynthetic process GO:1903409 8 0.017
determination of adult lifespan GO:0008340 11 0.017
cytoplasmic transport GO:0016482 234 0.016
tissue homeostasis GO:0001894 115 0.016
positive regulation of protein modification process GO:0031401 299 0.016
ribonucleoside monophosphate metabolic process GO:0009161 80 0.016
Fly
calcium ion transport GO:0006816 159 0.016
protein catabolic process GO:0030163 221 0.016
dicarboxylic acid metabolic process GO:0043648 18 0.016
ribonucleoside triphosphate metabolic process GO:0009199 220 0.016
Fly
regulation of transmembrane transport GO:0034762 128 0.016
wound healing GO:0042060 157 0.015
cellular carbohydrate metabolic process GO:0044262 119 0.015
fatty acid metabolic process GO:0006631 121 0.015
male sex differentiation GO:0046661 109 0.015
response to radiation GO:0009314 165 0.015
hydrogen peroxide metabolic process GO:0042743 16 0.015
hormone metabolic process GO:0042445 86 0.015
innate immune response GO:0045087 157 0.015
regulation of leukocyte differentiation GO:1902105 159 0.015
muscle tissue development GO:0060537 308 0.015
response to molecule of bacterial origin GO:0002237 143 0.015
peptide metabolic process GO:0006518 46 0.015
gonad development GO:0008406 141 0.015
nicotinamide nucleotide metabolic process GO:0046496 12 0.015
cellular response to acid chemical GO:0071229 68 0.015
age dependent response to oxidative stress GO:0001306 3 0.015
chromatin modification GO:0016568 187 0.015
organophosphate biosynthetic process GO:0090407 122 0.015
regulation of blood vessel size GO:0050880 56 0.015
regulation of lymphocyte activation GO:0051249 240 0.015
telencephalon development GO:0021537 186 0.015
negative regulation of cell proliferation GO:0008285 296 0.015
cellular amide metabolic process GO:0043603 58 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
Fly
divalent inorganic cation homeostasis GO:0072507 138 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.014
lipid localization GO:0010876 126 0.014
angiogenesis GO:0001525 201 0.014
cellular response to organic cyclic compound GO:0071407 87 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.014
developmental pigmentation GO:0048066 40 0.014
cellular chemical homeostasis GO:0055082 215 0.014
cellular transition metal ion homeostasis GO:0046916 32 0.014
regulation of multi organism process GO:0043900 111 0.014
digestive tract development GO:0048565 190 0.014
neuron migration GO:0001764 122 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
positive regulation of cellular amine metabolic process GO:0033240 5 0.014
phospholipid metabolic process GO:0006644 87 0.014
digestive system development GO:0055123 200 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
extrinsic apoptotic signaling pathway GO:0097191 126 0.014
embryonic epithelial tube formation GO:0001838 130 0.014
regulation of secretion GO:0051046 274 0.014
superoxide metabolic process GO:0006801 27 0.014
response to extracellular stimulus GO:0009991 127 0.014
response to osmotic stress GO:0006970 21 0.013
response to acid chemical GO:0001101 111 0.013
protein localization to membrane GO:0072657 108 0.013
vascular process in circulatory system GO:0003018 62 0.013
cellular response to amino acid stimulus GO:0071230 29 0.013
lymphocyte mediated immunity GO:0002449 139 0.013
regulation of hormone levels GO:0010817 211 0.013
blood vessel morphogenesis GO:0048514 285 0.013
regulation of cytokine production GO:0001817 266 0.013
nucleoside metabolic process GO:0009116 246 0.013
Fly
muscle cell differentiation GO:0042692 261 0.013
establishment of protein localization to organelle GO:0072594 118 0.013
plasma membrane organization GO:0007009 90 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
monocarboxylic acid biosynthetic process GO:0072330 61 0.012
molting cycle GO:0042303 90 0.012
cellular ion homeostasis GO:0006873 165 0.012
protein secretion GO:0009306 111 0.012
regulation of lipid metabolic process GO:0019216 118 0.012
production of molecular mediator of immune response GO:0002440 103 0.012
positive regulation of antimicrobial peptide production GO:0002225 1 0.012
heterocycle catabolic process GO:0046700 280 0.012
amide transport GO:0042886 138 0.012
gastrulation GO:0007369 116 0.012
mitochondrion morphogenesis GO:0070584 13 0.012
neural precursor cell proliferation GO:0061351 121 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
retinoid metabolic process GO:0001523 24 0.012
regulation of cellular response to stress GO:0080135 159 0.012
muscle fiber development GO:0048747 76 0.012
osteoclast differentiation GO:0030316 62 0.012
response to peptide GO:1901652 136 0.012
regulation of neuron apoptotic process GO:0043523 122 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.012
regulation of defense response GO:0031347 233 0.012
negative regulation of endopeptidase activity GO:0010951 44 0.012
multi multicellular organism process GO:0044706 109 0.011
camera type eye development GO:0043010 266 0.011
regulation of lymphocyte differentiation GO:0045619 107 0.011
cytokine production GO:0001816 319 0.011
positive regulation of cell development GO:0010720 237 0.011
cellular divalent inorganic cation homeostasis GO:0072503 127 0.011
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.011
organic hydroxy compound transport GO:0015850 93 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.011
negative regulation of phosphate metabolic process GO:0045936 184 0.011
nadh metabolic process GO:0006734 1 0.011
cellular response to estrogen stimulus GO:0071391 12 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.011
regulation of protein transport GO:0051223 163 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
calcium ion homeostasis GO:0055074 127 0.010
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.010
cardiac muscle tissue development GO:0048738 130 0.010
oxygen homeostasis GO:0032364 2 0.010
regulation of ion transmembrane transport GO:0034765 119 0.010
alpha amino acid biosynthetic process GO:1901607 15 0.010
negative regulation of cellular protein metabolic process GO:0032269 247 0.010
negative regulation of blood pressure GO:0045776 22 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
regulation of antibacterial peptide production GO:0002786 1 0.010
negative regulation of inflammatory response to antigenic stimulus GO:0002862 10 0.010
immune effector process GO:0002252 321 0.010
carbohydrate homeostasis GO:0033500 128 0.010
homeostasis of number of cells within a tissue GO:0048873 25 0.010
neuron death GO:0070997 154 0.010
aldehyde catabolic process GO:0046185 4 0.010
cell activation involved in immune response GO:0002263 126 0.010
regulation of mitochondrial translation GO:0070129 3 0.010

Aifm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.388
inherited metabolic disorder DOID:655 0 0.075
amino acid metabolic disorder DOID:9252 0 0.064
central nervous system disease DOID:331 0 0.045
disease of anatomical entity DOID:7 0 0.045
nervous system disease DOID:863 0 0.045
hematopoietic system disease DOID:74 0 0.044
blood coagulation disease DOID:1247 0 0.044
immune system disease DOID:2914 0 0.044
hemorrhagic disease DOID:2213 0 0.044
neurodegenerative disease DOID:1289 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
carbohydrate metabolic disorder DOID:2978 0 0.018
musculoskeletal system disease DOID:17 0 0.012
muscular disease DOID:0080000 0 0.012
blood platelet disease DOID:2218 0 0.011