Mus musculus

345 known processes

Apc

adenomatosis polyposis coli

(Aliases: mAPC,Min,AU020952,CC1,AW124434,AI047805)

Apc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regionalization GO:0003002 337 1.000
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 1.000
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 1.000
negative regulation of cell proliferation GO:0008285 296 1.000
negative regulation of phosphorylation GO:0042326 166 1.000
regulation of kinase activity GO:0043549 249 1.000
Human
stem cell maintenance GO:0019827 130 1.000
negative regulation of kinase activity GO:0033673 81 0.999
Human
regulation of wnt signaling pathway GO:0030111 123 0.999
regulation of transferase activity GO:0051338 263 0.999
Human
cell proliferation involved in heart valve morphogenesis GO:0003249 1 0.999
negative regulation of map kinase activity GO:0043407 34 0.999
pole plasm assembly GO:0007315 2 0.999
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.999
negative regulation of protein phosphorylation GO:0001933 126 0.999
Human
negative regulation of epithelial cell proliferation GO:0050680 64 0.999
organ growth GO:0035265 117 0.999
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.999
axon guidance GO:0007411 141 0.999
Fly
formation of radial glial scaffolds GO:0021943 4 0.999
oocyte axis specification GO:0007309 2 0.999
schwann cell proliferation GO:0014010 2 0.999
axonogenesis GO:0007409 274 0.998
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.998
negative regulation of protein modification process GO:0031400 163 0.998
Human
regulation of mapk cascade GO:0043408 248 0.998
positive regulation of protein modification process GO:0031401 299 0.998
embryonic skeletal system development GO:0048706 120 0.998
negative regulation of jun kinase activity GO:0043508 9 0.998
response to sterol GO:0036314 4 0.998
regulation of protein kinase activity GO:0045859 232 0.997
Human
metanephric mesenchyme morphogenesis GO:0072133 4 0.997
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.997
negative regulation of organ growth GO:0046621 17 0.997
germ line stem cell division GO:0042078 2 0.996
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.996
regulation of canonical wnt signaling pathway GO:0060828 82 0.996
negative regulation of glial cell proliferation GO:0060253 4 0.996
dna metabolic process GO:0006259 303 0.996
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.996
Human
regulation of smad protein import into nucleus GO:0060390 3 0.995
segmentation GO:0035282 93 0.995
cell cycle arrest GO:0007050 37 0.995
Human
mitotic cell cycle GO:0000278 195 0.995
female gamete generation GO:0007292 74 0.995
Fly
antral ovarian follicle growth GO:0001547 5 0.995
morphogenesis of a branching epithelium GO:0061138 193 0.995
regulation of neuron projection development GO:0010975 169 0.995
dna replication GO:0006260 52 0.994
genetic imprinting GO:0071514 27 0.994
response to organic cyclic compound GO:0014070 198 0.994
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.994
Human
regulation of cellular amino acid metabolic process GO:0006521 5 0.994
negative regulation of intracellular signal transduction GO:1902532 167 0.994
positive regulation of protein phosphorylation GO:0001934 242 0.993
regulation of cell cycle GO:0051726 281 0.993
regulation of protein stability GO:0031647 52 0.993
smad protein complex assembly GO:0007183 1 0.993
epithelial tube morphogenesis GO:0060562 303 0.993
germ cell development GO:0007281 185 0.993
Fly
gastrulation GO:0007369 116 0.993
Worm
positive regulation of mapk cascade GO:0043410 170 0.992
signal transduction by p53 class mediator GO:0072331 51 0.992
negative regulation of cell cycle GO:0045786 123 0.992
Human
mapk cascade GO:0000165 281 0.992
stem cell development GO:0048864 219 0.991
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.991
positive regulation of apoptotic signaling pathway GO:2001235 95 0.991
digestive tract morphogenesis GO:0048546 147 0.991
Worm
protein catabolic process GO:0030163 221 0.991
trachea formation GO:0060440 3 0.991
regulation of protein serine threonine kinase activity GO:0071900 157 0.991
Human
mammary gland morphogenesis GO:0060443 54 0.991
regulation of cellular ketone metabolic process GO:0010565 66 0.990
wnt signaling pathway GO:0016055 188 0.990
mammary gland epithelium development GO:0061180 65 0.990
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.990
blastoderm segmentation GO:0007350 13 0.990
negative regulation of protein metabolic process GO:0051248 282 0.990
Human
stem cell differentiation GO:0048863 268 0.990
cell fate commitment GO:0045165 210 0.989
Worm
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.989
protein localization to nucleus GO:0034504 121 0.989
regulation of peptidyl serine phosphorylation GO:0033135 39 0.989
digestive tract development GO:0048565 190 0.989
Worm
peptidyl amino acid modification GO:0018193 336 0.988
regulation of organ growth GO:0046620 61 0.988
regulation of epithelial cell proliferation GO:0050678 141 0.988
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 7 0.987
cell growth involved in cardiac muscle cell development GO:0061049 3 0.987
neuron projection extension GO:1990138 64 0.987
negative regulation of nervous system development GO:0051961 156 0.987
lateral mesodermal cell differentiation GO:0048371 3 0.987
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.986
Human
t cell activation GO:0042110 289 0.986
regulation of cell adhesion GO:0030155 154 0.986
kidney mesenchyme morphogenesis GO:0072131 4 0.986
mesoderm development GO:0007498 100 0.985
response to alcohol GO:0097305 48 0.985
mesendoderm development GO:0048382 3 0.985
regulation of protein import into nucleus GO:0042306 52 0.984
osteoblast fate commitment GO:0002051 4 0.984
regulation of t cell differentiation GO:0045580 83 0.984
oocyte differentiation GO:0009994 35 0.984
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.984
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.983
cellular response to dna damage stimulus GO:0006974 207 0.983
Human
regulation of protein targeting GO:1903533 61 0.983
cardiac muscle cell differentiation GO:0055007 69 0.982
nuclear transport GO:0051169 139 0.982
Worm
endothelial cell activation GO:0042118 1 0.982
trachea development GO:0060438 18 0.981
negative regulation of cell growth GO:0030308 44 0.981
positive regulation of smad protein import into nucleus GO:0060391 2 0.981
embryonic skeletal system morphogenesis GO:0048704 91 0.981
oocyte construction GO:0007308 2 0.979
positive regulation of apoptotic process GO:0043065 217 0.979
spermatogenesis GO:0007283 284 0.978
germline cell cycle switching mitotic to meiotic cell cycle GO:0051729 1 0.978
cellular response to organic cyclic compound GO:0071407 87 0.978
cardiac endothelial cell differentiation GO:0003348 4 0.978
protein localization to organelle GO:0033365 185 0.977
positive regulation of cell death GO:0010942 224 0.977
regulation of cell proliferation involved in heart valve morphogenesis GO:0003250 1 0.977
lateral mesoderm morphogenesis GO:0048369 3 0.976
peptidyl threonine phosphorylation GO:0018107 31 0.975
cell growth GO:0016049 130 0.975
cardiocyte differentiation GO:0035051 87 0.975
negative regulation of molecular function GO:0044092 258 0.975
Human
regulation of nucleocytoplasmic transport GO:0046822 73 0.974
male gamete generation GO:0048232 285 0.974
response to cholesterol GO:0070723 4 0.974
cellular response to cytokine stimulus GO:0071345 189 0.974
neural tube closure GO:0001843 90 0.974
cytoplasmic transport GO:0016482 234 0.973
Worm
negative regulation of phosphate metabolic process GO:0045936 184 0.972
fused antrum stage GO:0048165 1 0.972
endodermal cell fate specification GO:0001714 4 0.972
Worm
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.971
intrinsic apoptotic signaling pathway GO:0097193 132 0.971
regulation of actin cytoskeleton organization GO:0032956 84 0.971
regulation of cytoskeleton organization GO:0051493 122 0.970
mesenchyme development GO:0060485 152 0.970
t cell differentiation GO:0030217 174 0.969
erythrocyte differentiation GO:0030218 88 0.968
mesonephric tubule development GO:0072164 94 0.968
dendrite development GO:0016358 115 0.967
regulation of protein localization GO:0032880 231 0.967
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.967
microtubule based process GO:0007017 236 0.965
intracellular protein transport GO:0006886 204 0.965
Worm Fly
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.965
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.963
camera type eye development GO:0043010 266 0.962
positive regulation of axon extension GO:0045773 20 0.962
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.961
positive regulation of actin filament bundle assembly GO:0032233 11 0.960
cardiac muscle cell development GO:0055013 39 0.960
positive regulation of proteolysis GO:0045862 85 0.960
gland development GO:0048732 330 0.959
lateral mesoderm formation GO:0048370 3 0.959
regulation of neuron differentiation GO:0045664 281 0.959
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.959
branching morphogenesis of an epithelial tube GO:0048754 159 0.959
response to ionizing radiation GO:0010212 42 0.959
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.958
cellular response to growth factor stimulus GO:0071363 197 0.958
positive regulation of bmp signaling pathway GO:0030513 23 0.958
regulation of organelle organization GO:0033043 289 0.958
male sex differentiation GO:0046661 109 0.958
regulation of rho gtpase activity GO:0032319 58 0.957
protein modification by small protein conjugation or removal GO:0070647 207 0.957
regulation of intracellular protein transport GO:0033157 82 0.956
negative regulation of mitotic cell cycle GO:0045930 58 0.954
Human
osteoblast development GO:0002076 17 0.954
embryonic epithelial tube formation GO:0001838 130 0.953
renal system development GO:0072001 225 0.953
positive regulation of neuron differentiation GO:0045666 141 0.953
formation of primary germ layer GO:0001704 77 0.952
Worm
negative regulation of osteoblast proliferation GO:0033689 4 0.952
cellular ketone metabolic process GO:0042180 84 0.951
regulation of insulin receptor signaling pathway GO:0046626 21 0.951
morphogenesis of a branching structure GO:0001763 203 0.951
regulation of intracellular transport GO:0032386 159 0.950
positive regulation of transcription by galactose GO:0000411 1 0.950
neural tube formation GO:0001841 108 0.949
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.949
negative regulation of tor signaling GO:0032007 13 0.948
regulation of cellular component biogenesis GO:0044087 181 0.948
digestive system development GO:0055123 200 0.948
Worm
myelination GO:0042552 74 0.947
heart formation GO:0060914 16 0.947
regulation of axon extension GO:0030516 43 0.946
trophectodermal cellular morphogenesis GO:0001831 3 0.945
canonical wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation GO:0061324 2 0.945
regulation of hormone secretion GO:0046883 88 0.944
carbon catabolite activation of transcription GO:0045991 4 0.944
negative regulation of cardiac muscle tissue development GO:0055026 8 0.943
negative regulation of growth GO:0045926 99 0.943
positive regulation of glial cell proliferation GO:0060252 4 0.942
spermatid differentiation GO:0048515 115 0.941
regulation of mitotic cell cycle GO:0007346 126 0.941
gonad development GO:0008406 141 0.941
response to growth factor GO:0070848 198 0.940
regulation of peptidyl threonine phosphorylation GO:0010799 12 0.939
neural tube development GO:0021915 160 0.939
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.938
positive regulation of stem cell proliferation GO:2000648 59 0.938
angiogenesis GO:0001525 201 0.937
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.937
regulation of b cell tolerance induction GO:0002661 2 0.936
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.936
lateral mesodermal cell fate commitment GO:0048372 2 0.935
leukocyte differentiation GO:0002521 342 0.935
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.934
cell division GO:0051301 120 0.933
hindbrain radial glia guided cell migration GO:0021932 12 0.933
protein targeting GO:0006605 143 0.933
blastocyst development GO:0001824 80 0.931
insulin receptor signaling pathway GO:0008286 49 0.931
positive regulation of protein kinase activity GO:0045860 144 0.931
peptidyl threonine modification GO:0018210 31 0.931
olfactory learning GO:0008355 2 0.930
regulation of cell cycle process GO:0010564 160 0.929
regulation of glial cell proliferation GO:0060251 8 0.929
small gtpase mediated signal transduction GO:0007264 97 0.928
cell aging GO:0007569 35 0.928
negative regulation of cell growth involved in cardiac muscle cell development GO:0061052 2 0.927
positive regulation of cell development GO:0010720 237 0.926
negative regulation of cellular amine metabolic process GO:0033239 1 0.926
negative regulation of cell development GO:0010721 169 0.925
Fly
regulation of transcription factor import into nucleus GO:0042990 24 0.922
protein import into nucleus GO:0006606 95 0.921
pallium development GO:0021543 120 0.920
heart field specification GO:0003128 6 0.920
oocyte anterior posterior axis specification GO:0007314 2 0.919
alpha beta t cell differentiation GO:0046632 69 0.919
regulation of cell migration GO:0030334 219 0.918
regulation of cell projection organization GO:0031344 206 0.917
Human
oogenesis GO:0048477 56 0.917
Fly
skeletal system development GO:0001501 356 0.916
developmental maturation GO:0021700 193 0.916
positive regulation of transferase activity GO:0051347 167 0.916
lymphocyte differentiation GO:0030098 242 0.915
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.915
positive regulation of cell cycle GO:0045787 92 0.914
heart growth GO:0060419 45 0.914
response to radiation GO:0009314 165 0.914
chondrocyte development GO:0002063 24 0.913
regulation of anatomical structure size GO:0090066 178 0.912
chondrocyte differentiation GO:0002062 72 0.910
regulation of cell motility GO:2000145 236 0.909
pathway restricted smad protein phosphorylation GO:0060389 10 0.909
embryonic hemopoiesis GO:0035162 23 0.908
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.908
regulation of cell division GO:0051302 76 0.907
positive regulation of cellular component biogenesis GO:0044089 94 0.907
ubiquitin dependent protein catabolic process GO:0006511 129 0.906
regulation of ras gtpase activity GO:0032318 88 0.906
negative regulation of bmp signaling pathway GO:0030514 35 0.904
regulation of cell size GO:0008361 72 0.903
neuron projection guidance GO:0097485 141 0.903
Fly
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.901
single organism nuclear import GO:1902593 95 0.900
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.899
mitotic cell cycle process GO:1903047 159 0.899
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.899
cell adhesion GO:0007155 329 0.898
actin cytoskeleton organization GO:0030036 220 0.898
Fly
positive regulation of intracellular protein transport GO:0090316 42 0.897
bmp signaling pathway GO:0030509 93 0.897
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.896
stem cell proliferation GO:0072089 117 0.895
Fly
cellular senescence GO:0090398 11 0.895
actin filament organization GO:0007015 113 0.895
positive regulation of gene silencing by mirna GO:2000637 1 0.895
tor signaling GO:0031929 21 0.894
synapse organization GO:0050808 125 0.894
development of primary sexual characteristics GO:0045137 143 0.893
skeletal system morphogenesis GO:0048705 203 0.892
cell type specific apoptotic process GO:0097285 268 0.892
chemotaxis GO:0006935 247 0.890
Fly
positive regulation of kinase activity GO:0033674 155 0.890
modification dependent macromolecule catabolic process GO:0043632 133 0.886
endothelial cell differentiation GO:0045446 41 0.884
centromeric sister chromatid cohesion GO:0070601 3 0.884
regulation of microtubule based process GO:0032886 52 0.884
meiotic cell cycle GO:0051321 122 0.881
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.881
regulation of protein localization to nucleus GO:1900180 60 0.875
meiotic chromosome segregation GO:0045132 19 0.874
regulation of lymphocyte differentiation GO:0045619 107 0.874
regulation of cardiac muscle cell proliferation GO:0060043 23 0.873
hair cycle GO:0042633 90 0.872
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.871
response to organonitrogen compound GO:0010243 246 0.870
regulation of transcription by galactose GO:0000409 1 0.870
regulation of hydrolase activity GO:0051336 246 0.869
regulation of cellular catabolic process GO:0031329 242 0.868
Human
mitotic cell cycle arrest GO:0071850 4 0.867
cellular macromolecule catabolic process GO:0044265 206 0.867
regulation of stem cell differentiation GO:2000736 50 0.867
embryonic organ morphogenesis GO:0048562 276 0.867
positive regulation of mitotic cell cycle GO:0045931 41 0.866
negative regulation of mapk cascade GO:0043409 65 0.865
cellular amine metabolic process GO:0044106 44 0.864
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.860
regulation of establishment of protein localization GO:0070201 181 0.859
positive regulation of stress fiber assembly GO:0051496 9 0.859
regulation of leukocyte differentiation GO:1902105 159 0.857
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.855
negative regulation of fibroblast migration GO:0010764 2 0.855
somitogenesis GO:0001756 69 0.853
mitotic g1 dna damage checkpoint GO:0031571 4 0.853
protein sumoylation GO:0016925 14 0.851
embryonic skeletal joint development GO:0072498 13 0.851
modification dependent protein catabolic process GO:0019941 133 0.850
forebrain development GO:0030900 302 0.850
extrinsic apoptotic signaling pathway GO:0097191 126 0.849
positive regulation of stem cell differentiation GO:2000738 23 0.848
regulation of jak stat cascade GO:0046425 34 0.848
endodermal cell fate commitment GO:0001711 12 0.847
Worm
cellular response to drug GO:0035690 15 0.846
prostate gland morphogenetic growth GO:0060737 4 0.845
regulation of vasculature development GO:1901342 88 0.845
cellular response to gamma radiation GO:0071480 4 0.844
positive regulation of brown fat cell differentiation GO:0090336 4 0.843
negative regulation of cellular protein metabolic process GO:0032269 247 0.842
Human
regulation of cardiac muscle tissue growth GO:0055021 26 0.838
positive regulation of nervous system development GO:0051962 221 0.838
regulation of mesoderm development GO:2000380 12 0.835
regulation of apoptotic signaling pathway GO:2001233 197 0.835
cell matrix adhesion GO:0007160 68 0.834
positive regulation of endothelial cell differentiation GO:0045603 7 0.834
odontogenesis GO:0042476 78 0.832
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.831
liver development GO:0001889 66 0.831
appendage morphogenesis GO:0035107 149 0.830
somatic stem cell maintenance GO:0035019 47 0.830
cellular response to peptide GO:1901653 92 0.829
peptidyl serine modification GO:0018209 83 0.828
positive regulation of cell migration GO:0030335 109 0.827
mitochondrial dna repair GO:0043504 3 0.827
regulation of actin filament based process GO:0032970 99 0.826
metanephric glomerular mesangium development GO:0072223 3 0.826
meiotic cell cycle process GO:1903046 77 0.825
canonical wnt signaling pathway GO:0060070 130 0.823
epithelial cell proliferation GO:0050673 174 0.822
regulation of protein transport GO:0051223 163 0.822
peptidyl tyrosine phosphorylation GO:0018108 143 0.821
central nervous system neuron differentiation GO:0021953 162 0.818
actin filament bundle assembly GO:0051017 40 0.817
regulation of osteoblast proliferation GO:0033688 15 0.817
physiological cardiac muscle hypertrophy GO:0003301 3 0.817
regulation of cellular response to growth factor stimulus GO:0090287 82 0.815
retinal ganglion cell axon guidance GO:0031290 18 0.813
male gonad development GO:0008584 88 0.813
regulation of lateral mesodermal cell fate specification GO:0048378 2 0.813
neuronal action potential GO:0019228 54 0.811
protein modification by small protein conjugation GO:0032446 187 0.810
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.809
epithelial tube formation GO:0072175 130 0.809
leukocyte proliferation GO:0070661 172 0.808
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.807
rho protein signal transduction GO:0007266 32 0.806
tube closure GO:0060606 91 0.805
negative regulation of endothelial cell proliferation GO:0001937 8 0.804
positive regulation of programmed cell death GO:0043068 218 0.802
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 0.801
response to nutrient levels GO:0031667 109 0.801
body morphogenesis GO:0010171 45 0.800
Worm
endocardial cushion formation GO:0003272 13 0.800
mesoderm morphogenesis GO:0048332 64 0.797
cellular response to peptide hormone stimulus GO:0071375 92 0.796
wnt signaling pathway involved in somitogenesis GO:0090244 4 0.796
negative regulation of peptidyl serine phosphorylation GO:0033137 10 0.795
positive regulation of leukocyte differentiation GO:1902107 86 0.794
bone development GO:0060348 120 0.793
anti mullerian hormone signaling pathway GO:1990262 1 0.793
regulation of pathway restricted smad protein phosphorylation GO:0060393 6 0.793
negative regulation of endothelial cell differentiation GO:0045602 2 0.792
mammary gland duct morphogenesis GO:0060603 38 0.791
negative regulation of cell cycle phase transition GO:1901988 48 0.790
Human
cardiac muscle tissue growth GO:0055017 37 0.788
nucleoside phosphate catabolic process GO:1901292 222 0.787
cardiac muscle tissue development GO:0048738 130 0.787
regulation of binding GO:0051098 111 0.786
endochondral bone morphogenesis GO:0060350 50 0.785
ras protein signal transduction GO:0007265 77 0.785
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.783
establishment of protein localization to organelle GO:0072594 118 0.783
urogenital system development GO:0001655 261 0.782
regulation of endothelial cell differentiation GO:0045601 10 0.780
lung induction GO:0060492 3 0.777
bronchus morphogenesis GO:0060434 2 0.776
regulation of stress fiber assembly GO:0051492 15 0.776
regulation of cellular component size GO:0032535 121 0.776
mesenchyme morphogenesis GO:0072132 32 0.775
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.773
t cell receptor v d j recombination GO:0033153 5 0.772
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.772
endocardial cushion morphogenesis GO:0003203 18 0.772
regulation of stress activated mapk cascade GO:0032872 69 0.769
inflammatory response GO:0006954 244 0.768
endoderm formation GO:0001706 20 0.764
Worm
regulation of fibroblast proliferation GO:0048145 34 0.763
regulation of inositol 1 4 5 trisphosphate sensitive calcium release channel activity GO:0031585 2 0.761
protein kinase b signaling GO:0043491 74 0.759
foregut morphogenesis GO:0007440 12 0.757
growth plate cartilage chondrocyte development GO:0003431 3 0.756
heart valve development GO:0003170 23 0.756
physiological muscle hypertrophy GO:0003298 3 0.754
peptide transport GO:0015833 133 0.754
regulation of cytoplasmic transport GO:1903649 112 0.754
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.752
protein autophosphorylation GO:0046777 61 0.752
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.751
positive regulation of growth GO:0045927 104 0.751
embryonic heart tube morphogenesis GO:0003143 51 0.749
regulation of cell growth GO:0001558 91 0.748
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.747
regulation of stem cell proliferation GO:0072091 78 0.746
response to transforming growth factor beta GO:0071559 88 0.745
limb morphogenesis GO:0035108 149 0.744
macromolecule catabolic process GO:0009057 281 0.742
primary neural tube formation GO:0014020 95 0.742
regulation of anti mullerian hormone signaling pathway GO:1902612 1 0.742
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.741
Human
bone morphogenesis GO:0060349 78 0.740
heart valve morphogenesis GO:0003179 21 0.739
cellular response to organonitrogen compound GO:0071417 145 0.735
regulation of cellular senescence GO:2000772 6 0.735
cell maturation GO:0048469 127 0.734
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.733
sertoli cell development GO:0060009 15 0.732
regulation of mitochondrial membrane permeability GO:0046902 17 0.732
regulation of reproductive process GO:2000241 66 0.732
positive regulation of chromosome segregation GO:0051984 4 0.732
regulation of cardiac muscle tissue development GO:0055024 31 0.731
regulation of hippo signaling GO:0035330 1 0.731
activation of mapkk activity GO:0000186 15 0.730
kidney development GO:0001822 213 0.730
cellular response to insulin stimulus GO:0032869 78 0.729
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.728
ribonucleoside triphosphate metabolic process GO:0009199 220 0.728
negative regulation of gliogenesis GO:0014014 23 0.727
muscle cell differentiation GO:0042692 261 0.725
response to insulin GO:0032868 100 0.725
positive regulation of cell projection organization GO:0031346 95 0.724
Human
nuclear division GO:0000280 158 0.722
regulation of jnk cascade GO:0046328 62 0.722
female sex differentiation GO:0046660 84 0.722
lateral mesodermal cell fate specification GO:0048377 2 0.721
cellular amino acid metabolic process GO:0006520 103 0.720
skin development GO:0043588 220 0.720
morphogenesis of embryonic epithelium GO:0016331 159 0.720
positive regulation of rho gtpase activity GO:0032321 41 0.718
cellular response to radiation GO:0071478 28 0.715
developmental growth involved in morphogenesis GO:0060560 138 0.715
odontogenesis of dentin containing tooth GO:0042475 66 0.714
cell fate specification GO:0001708 72 0.713
Worm
embryonic heart tube development GO:0035050 65 0.713
synaptic growth at neuromuscular junction GO:0051124 6 0.712
layer formation in cerebral cortex GO:0021819 13 0.711
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.710
microtubule cytoskeleton organization GO:0000226 157 0.708
dephosphorylation GO:0016311 129 0.707
glial cell proliferation GO:0014009 10 0.707
regulation of mesodermal cell fate specification GO:0042661 5 0.707
regulation of membrane permeability GO:0090559 18 0.703
regulation of chondrocyte differentiation GO:0032330 33 0.702
maternal placenta development GO:0001893 20 0.701
apoptotic signaling pathway GO:0097190 306 0.701
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.698
negative regulation of wnt signaling pathway GO:0030178 73 0.698
mammary gland epithelial cell proliferation GO:0033598 24 0.697
neuron apoptotic process GO:0051402 142 0.697
nephrogenic mesenchyme development GO:0072076 3 0.696
peptidyl serine phosphorylation GO:0018105 74 0.696
protein import GO:0017038 101 0.695
mesenchymal cell differentiation GO:0048762 107 0.695
ameboidal type cell migration GO:0001667 128 0.694
maternal process involved in female pregnancy GO:0060135 32 0.692

Apc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 1.000
Human
cancer DOID:162 0 1.000
Human
organ system cancer DOID:0050686 0 1.000
Human
endocrine gland cancer DOID:170 0 0.991
pancreatic cancer DOID:1793 0 0.909
gastrointestinal system cancer DOID:3119 0 0.836
Human
liver carcinoma DOID:686 0 0.836
Human
liver cancer DOID:3571 0 0.836
Human
large intestine cancer DOID:5672 0 0.815
Human
colon cancer DOID:219 0 0.815
Human
intestinal cancer DOID:10155 0 0.815
Human
colorectal cancer DOID:9256 0 0.815
Human