Mus musculus

11 known processes

Apex1

apurinic/apyrimidinic endonuclease 1

(Aliases: Apex,Ref-1,HAP1,APE)

Apex1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic cyclic compound catabolic process GO:1901361 295 0.313
Human Worm
amine metabolic process GO:0009308 45 0.178
negative regulation of cell proliferation GO:0008285 296 0.139
chromatin organization GO:0006325 206 0.138
nucleoside phosphate metabolic process GO:0006753 338 0.136
nucleoside triphosphate metabolic process GO:0009141 230 0.133
cellular macromolecule catabolic process GO:0044265 206 0.130
Human Worm
epithelial cell proliferation GO:0050673 174 0.127
regulation of cellular amino acid metabolic process GO:0006521 5 0.126
dna metabolic process GO:0006259 303 0.125
Human Worm
rna processing GO:0006396 105 0.117
mrna metabolic process GO:0016071 84 0.115
organophosphate biosynthetic process GO:0090407 122 0.109
gland development GO:0048732 330 0.086
regulation of cellular amine metabolic process GO:0033238 20 0.083
regulation of cellular ketone metabolic process GO:0010565 66 0.077
cytoplasmic transport GO:0016482 234 0.076
nucleoside metabolic process GO:0009116 246 0.075
nucleotide metabolic process GO:0009117 332 0.074
cellular amino acid metabolic process GO:0006520 103 0.069
posttranscriptional regulation of gene expression GO:0010608 155 0.067
Human
regulation of epithelial cell proliferation GO:0050678 141 0.067
ribose phosphate metabolic process GO:0019693 291 0.066
cellular response to dna damage stimulus GO:0006974 207 0.062
Human Worm
cellular ketone metabolic process GO:0042180 84 0.062
cellular amine metabolic process GO:0044106 44 0.062
embryonic organ morphogenesis GO:0048562 276 0.060
Zebrafish
atp metabolic process GO:0046034 75 0.059
cellular nitrogen compound catabolic process GO:0044270 280 0.059
Human Worm
camera type eye development GO:0043010 266 0.059
purine containing compound metabolic process GO:0072521 311 0.059
macromolecule catabolic process GO:0009057 281 0.055
Human Worm
purine nucleotide metabolic process GO:0006163 302 0.055
peptidyl amino acid modification GO:0018193 336 0.054
t cell activation GO:0042110 289 0.054
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.054
positive regulation of protein modification process GO:0031401 299 0.054
rhythmic process GO:0048511 174 0.053
development of primary sexual characteristics GO:0045137 143 0.053
rna splicing GO:0008380 54 0.051
regulation of organelle organization GO:0033043 289 0.051
leukocyte proliferation GO:0070661 172 0.049
chromatin modification GO:0016568 187 0.049
chemotaxis GO:0006935 247 0.048
regulation of organ morphogenesis GO:2000027 144 0.048
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.047
hematopoietic progenitor cell differentiation GO:0002244 143 0.046
cytokine production GO:0001816 319 0.046
lymphocyte proliferation GO:0046651 164 0.045
transmembrane transport GO:0055085 412 0.045
organonitrogen compound biosynthetic process GO:1901566 192 0.045
myeloid cell differentiation GO:0030099 233 0.043
nucleobase containing small molecule metabolic process GO:0055086 352 0.043
regulation of ion transport GO:0043269 215 0.043
gonad development GO:0008406 141 0.043
female gamete generation GO:0007292 74 0.043
intrinsic apoptotic signaling pathway GO:0097193 132 0.043
positive regulation of cellular amine metabolic process GO:0033240 5 0.043
apoptotic signaling pathway GO:0097190 306 0.041
regulation of cell migration GO:0030334 219 0.041
covalent chromatin modification GO:0016569 163 0.040
actin cytoskeleton organization GO:0030036 220 0.040
regulation of protein localization GO:0032880 231 0.040
nucleoside phosphate biosynthetic process GO:1901293 79 0.040
cellular response to organonitrogen compound GO:0071417 145 0.039
small gtpase mediated signal transduction GO:0007264 97 0.039
sensory organ morphogenesis GO:0090596 242 0.039
negative regulation of epithelial cell proliferation GO:0050680 64 0.039
negative regulation of phosphate metabolic process GO:0045936 184 0.039
glycosyl compound metabolic process GO:1901657 246 0.039
generation of precursor metabolites and energy GO:0006091 103 0.038
mapk cascade GO:0000165 281 0.037
organelle fission GO:0048285 170 0.037
rna splicing via transesterification reactions GO:0000375 43 0.036
nucleotide biosynthetic process GO:0009165 78 0.036
ras protein signal transduction GO:0007265 77 0.036
macromolecule methylation GO:0043414 120 0.036
ion transmembrane transport GO:0034220 361 0.035
glial cell differentiation GO:0010001 131 0.035
cell division GO:0051301 120 0.035
nucleoside phosphate catabolic process GO:1901292 222 0.035
cellular response to cytokine stimulus GO:0071345 189 0.035
negative regulation of molecular function GO:0044092 258 0.035
positive regulation of apoptotic process GO:0043065 217 0.035
maturation of ssu rrna GO:0030490 1 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.034
purine nucleoside metabolic process GO:0042278 241 0.034
purine nucleotide biosynthetic process GO:0006164 65 0.032
regulation of inflammatory response GO:0050727 147 0.032
histone modification GO:0016570 159 0.032
regulation of cell cycle GO:0051726 281 0.032
negative regulation of protein metabolic process GO:0051248 282 0.032
regionalization GO:0003002 337 0.032
transcription coupled nucleotide excision repair GO:0006283 2 0.031
dna repair GO:0006281 107 0.031
Human Worm
positive regulation of cell development GO:0010720 237 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.031
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.030
mitochondrion organization GO:0007005 134 0.030
neuron projection guidance GO:0097485 141 0.030
regulation of proteolysis GO:0030162 164 0.030
cation transport GO:0006812 399 0.030
positive regulation of protein phosphorylation GO:0001934 242 0.029
stem cell differentiation GO:0048863 268 0.029
regulation of transmembrane transport GO:0034762 128 0.029
regulation of hydrolase activity GO:0051336 246 0.029
ribonucleotide metabolic process GO:0009259 291 0.028
respiratory system development GO:0060541 190 0.028
ribonucleoside triphosphate metabolic process GO:0009199 220 0.028
mitotic cell cycle GO:0000278 195 0.028
regulation of membrane potential GO:0042391 192 0.028
protein modification by small protein conjugation or removal GO:0070647 207 0.028
nuclear division GO:0000280 158 0.027
cellular homeostasis GO:0019725 240 0.027
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.027
regulation of hormone levels GO:0010817 211 0.027
ribonucleoside metabolic process GO:0009119 245 0.026
regulation of feeding behavior GO:0060259 3 0.026
positive regulation of programmed cell death GO:0043068 218 0.026
purine containing compound biosynthetic process GO:0072522 70 0.026
dna dealkylation GO:0035510 11 0.026
Human
nitrogen compound transport GO:0071705 271 0.026
branching morphogenesis of an epithelial tube GO:0048754 159 0.026
methylation GO:0032259 134 0.026
trna wobble uridine modification GO:0002098 2 0.025
protein processing GO:0016485 163 0.025
histone methylation GO:0016571 71 0.025
leukocyte migration GO:0050900 124 0.025
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.025
ossification GO:0001503 216 0.025
positive regulation of cell death GO:0010942 224 0.025
regulation of defense response GO:0031347 233 0.024
negative regulation of protein phosphorylation GO:0001933 126 0.024
modification dependent macromolecule catabolic process GO:0043632 133 0.024
response to acid chemical GO:0001101 111 0.024
purine ribonucleotide metabolic process GO:0009150 290 0.024
purine containing compound catabolic process GO:0072523 213 0.024
male gamete generation GO:0048232 285 0.024
regulation of mapk cascade GO:0043408 248 0.024
negative regulation of apoptotic signaling pathway GO:2001234 104 0.024
trna wobble base modification GO:0002097 2 0.024
cation homeostasis GO:0055080 212 0.024
negative regulation of intracellular signal transduction GO:1902532 167 0.023
ribonucleoside monophosphate metabolic process GO:0009161 80 0.023
leukocyte differentiation GO:0002521 342 0.023
protein maturation GO:0051604 176 0.023
sensory perception GO:0007600 245 0.023
regulation of neuron differentiation GO:0045664 281 0.023
mrna processing GO:0006397 63 0.023
carbohydrate derivative biosynthetic process GO:1901137 183 0.022
segmentation GO:0035282 93 0.022
wound healing GO:0042060 157 0.022
developmental growth involved in morphogenesis GO:0060560 138 0.022
regulation of leukocyte differentiation GO:1902105 159 0.022
molting cycle GO:0042303 90 0.022
regulation of cell growth GO:0001558 91 0.022
axonogenesis GO:0007409 274 0.021
regulation of ion transmembrane transport GO:0034765 119 0.021
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.021
multicellular organismal homeostasis GO:0048871 164 0.021
carboxylic acid biosynthetic process GO:0046394 86 0.020
negative regulation of phosphorylation GO:0042326 166 0.020
cellular lipid metabolic process GO:0044255 323 0.020
cellular response to acid chemical GO:0071229 68 0.020
inorganic cation transmembrane transport GO:0098662 207 0.020
nuclear transport GO:0051169 139 0.020
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.020
regulation of cell motility GO:2000145 236 0.019
cellular protein catabolic process GO:0044257 155 0.019
response to organonitrogen compound GO:0010243 246 0.019
nucleoside triphosphate catabolic process GO:0009143 205 0.019
activation of immune response GO:0002253 138 0.019
regulation of purine nucleotide metabolic process GO:1900542 169 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
innate immune response GO:0045087 157 0.019
gliogenesis GO:0042063 141 0.019
regulation of cytokine production GO:0001817 266 0.019
anion transport GO:0006820 177 0.019
purine nucleotide catabolic process GO:0006195 211 0.018
negative regulation of cell development GO:0010721 169 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
anatomical structure homeostasis GO:0060249 145 0.018
double strand break repair via nonhomologous end joining GO:0006303 10 0.018
striated muscle tissue development GO:0014706 293 0.018
purine nucleoside monophosphate metabolic process GO:0009126 81 0.017
cell adhesion GO:0007155 329 0.017
morphogenesis of a branching epithelium GO:0061138 193 0.017
negative regulation of multi organism process GO:0043901 68 0.017
protein ubiquitination GO:0016567 171 0.017
protein acylation GO:0043543 64 0.017
divalent inorganic cation homeostasis GO:0072507 138 0.017
alpha amino acid metabolic process GO:1901605 59 0.017
engulfment of apoptotic cell GO:0043652 3 0.017
response to organic cyclic compound GO:0014070 198 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
metal ion homeostasis GO:0055065 189 0.017
forebrain development GO:0030900 302 0.017
t cell differentiation GO:0030217 174 0.017
carbohydrate derivative catabolic process GO:1901136 231 0.016
inflammatory response GO:0006954 244 0.016
locomotory behavior GO:0007626 195 0.016
negative regulation of cell cycle GO:0045786 123 0.016
intracellular receptor signaling pathway GO:0030522 74 0.016
mrna 3 end processing GO:0031124 16 0.016
negative regulation of protein modification process GO:0031400 163 0.016
ribose phosphate biosynthetic process GO:0046390 59 0.016
germ cell development GO:0007281 185 0.016
retina development in camera type eye GO:0060041 119 0.016
purine ribonucleoside metabolic process GO:0046128 241 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
cell growth GO:0016049 130 0.016
oxidation reduction process GO:0055114 342 0.016
Human
spermatogenesis GO:0007283 284 0.015
ncrna processing GO:0034470 26 0.015
mesenchymal cell differentiation GO:0048762 107 0.015
signal transduction by p53 class mediator GO:0072331 51 0.015
sodium ion transport GO:0006814 73 0.015
cellular response to hormone stimulus GO:0032870 150 0.015
negative regulation of cellular amine metabolic process GO:0033239 1 0.015
cellular response to oxidative stress GO:0034599 76 0.015
regulation of sarcomere organization GO:0060297 4 0.015
cellular chemical homeostasis GO:0055082 215 0.015
canonical wnt signaling pathway GO:0060070 130 0.015
epidermis development GO:0008544 187 0.015
reactive oxygen species metabolic process GO:0072593 84 0.015
negative regulation of phosphorus metabolic process GO:0010563 184 0.015
regulation of jak stat cascade GO:0046425 34 0.015
regulation of protein kinase activity GO:0045859 232 0.015
calcium ion transport GO:0006816 159 0.015
regulation of establishment of protein localization GO:0070201 181 0.015
positive regulation of cellular respiration GO:1901857 3 0.015
regulation of endopeptidase activity GO:0052548 89 0.014
positive regulation of peptidase activity GO:0010952 49 0.014
hematopoietic stem cell differentiation GO:0060218 8 0.014
cellular response to external stimulus GO:0071496 88 0.014
mrna splicing via spliceosome GO:0000398 43 0.014
oocyte anterior posterior axis specification GO:0007314 2 0.014
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.014
cell type specific apoptotic process GO:0097285 268 0.014
cation transmembrane transport GO:0098655 266 0.014
negative regulation of immune system process GO:0002683 209 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.014
purine nucleoside triphosphate catabolic process GO:0009146 203 0.014
regulation of kinase activity GO:0043549 249 0.013
protein modification by small protein conjugation GO:0032446 187 0.013
purine nucleoside catabolic process GO:0006152 205 0.013
wnt signaling pathway GO:0016055 188 0.013
notch signaling pathway GO:0007219 71 0.013
regulation of ras protein signal transduction GO:0046578 114 0.013
purine nucleoside triphosphate metabolic process GO:0009144 226 0.013
positive regulation of mapk cascade GO:0043410 170 0.013
blastocyst development GO:0001824 80 0.013
inorganic ion transmembrane transport GO:0098660 234 0.013
regulation of secretion by cell GO:1903530 249 0.013
oogenesis GO:0048477 56 0.013
myeloid leukocyte differentiation GO:0002573 119 0.013
nucleotide catabolic process GO:0009166 217 0.013
nucleocytoplasmic transport GO:0006913 139 0.013
pharynx development GO:0060465 1 0.013
regulation of mitotic cell cycle phase transition GO:1901990 73 0.013
response to drug GO:0042493 75 0.013
aromatic compound catabolic process GO:0019439 286 0.013
Human Worm
regulation of cellular response to stress GO:0080135 159 0.013
Human
muscle tissue development GO:0060537 308 0.013
regulation of transporter activity GO:0032409 57 0.012
morphogenesis of a branching structure GO:0001763 203 0.012
response to oxidative stress GO:0006979 123 0.012
multicellular organismal signaling GO:0035637 91 0.012
mesenchyme development GO:0060485 152 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
peptidyl lysine modification GO:0018205 77 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
urogenital system development GO:0001655 261 0.012
maturation of lsu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000463 1 0.012
cellular response to lipid GO:0071396 145 0.012
peptidyl lysine acetylation GO:0018394 45 0.012
endocytosis GO:0006897 168 0.012
small molecule biosynthetic process GO:0044283 132 0.012
synaptic transmission GO:0007268 329 0.012
response to extracellular stimulus GO:0009991 127 0.012
dna dependent dna replication GO:0006261 24 0.012
axon guidance GO:0007411 141 0.012
nucleoside monophosphate metabolic process GO:0009123 85 0.012
response to inorganic substance GO:0010035 96 0.012
multicellular organism growth GO:0035264 161 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.012
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.012
response to peptide GO:1901652 136 0.012
amide transport GO:0042886 138 0.011
divalent metal ion transport GO:0070838 172 0.011
organophosphate catabolic process GO:0046434 232 0.011
regulation of glial cell differentiation GO:0045685 41 0.011
regulation of intracellular protein transport GO:0033157 82 0.011
protein localization to organelle GO:0033365 185 0.011
negative regulation of hydrolase activity GO:0051346 71 0.011
cellular protein complex assembly GO:0043623 116 0.011
mitotic cell cycle process GO:1903047 159 0.011
peptide secretion GO:0002790 114 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
polyamine biosynthetic process GO:0006596 2 0.011
blood circulation GO:0008015 195 0.011
Zebrafish
interspecies interaction between organisms GO:0044419 83 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
organic acid biosynthetic process GO:0016053 86 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
placenta development GO:0001890 140 0.011
regulation of neuron projection development GO:0010975 169 0.011
body morphogenesis GO:0010171 45 0.011
regulation of protein catabolic process GO:0042176 108 0.011
circulatory system process GO:0003013 197 0.011
Zebrafish
nuclear export GO:0051168 34 0.011
skin development GO:0043588 220 0.011
positive regulation of cytokine production GO:0001819 174 0.011
peptide transport GO:0015833 133 0.011
mesenchymal cell development GO:0014031 93 0.011
regulation of rna splicing GO:0043484 37 0.011
skeletal system morphogenesis GO:0048705 203 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.011
negative regulation of growth GO:0045926 99 0.011
developmental programmed cell death GO:0010623 41 0.010
regulation of myeloid cell differentiation GO:0045637 96 0.010
cellular response to peptide GO:1901653 92 0.010
organelle localization GO:0051640 179 0.010
protein oligomerization GO:0051259 67 0.010
protein kinase b signaling GO:0043491 74 0.010
oocyte construction GO:0007308 2 0.010
dna demethylation GO:0080111 10 0.010
Human
divalent inorganic cation transport GO:0072511 178 0.010
cellularization GO:0007349 1 0.010
positive regulation of proteolysis GO:0045862 85 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.010
regulation of protein processing GO:0070613 96 0.010
peptidyl tyrosine modification GO:0018212 145 0.010
ribonucleotide biosynthetic process GO:0009260 59 0.010
digestive system development GO:0055123 200 0.010
protein catabolic process GO:0030163 221 0.010
regulation of protein kinase b signaling GO:0051896 56 0.010

Apex1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
nervous system disease DOID:863 0 0.028
central nervous system disease DOID:331 0 0.022
neurodegenerative disease DOID:1289 0 0.022
disease of cellular proliferation DOID:14566 0 0.012