Mus musculus

323 known processes

App

amyloid beta (A4) precursor protein

(Aliases: Cvap,E030013M08Rik,Ag,Adap,Abpp,Abeta,betaApp)

App biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
copper ion homeostasis GO:0055070 9 0.998
neuroblast division in subventricular zone GO:0021849 2 0.997
regulation of cellular amino acid metabolic process GO:0006521 5 0.991
negative regulation of neuron differentiation GO:0045665 101 0.990
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.989
cell adhesion GO:0007155 329 0.984
visual learning GO:0008542 44 0.982
morphogenesis of a polarized epithelium GO:0001738 37 0.981
microtubule based transport GO:0010970 50 0.981
mrna polyadenylation GO:0006378 5 0.973
cognition GO:0050890 149 0.971
regulation of protein tyrosine kinase activity GO:0061097 17 0.971
regulation of neuron differentiation GO:0045664 281 0.970
axonogenesis GO:0007409 274 0.967
cellular copper ion homeostasis GO:0006878 8 0.964
peptidyl tyrosine modification GO:0018212 145 0.963
ionotropic glutamate receptor signaling pathway GO:0035235 29 0.962
sterol metabolic process GO:0016125 58 0.961
associative learning GO:0008306 61 0.950
learning GO:0007612 98 0.948
negative regulation of protein metabolic process GO:0051248 282 0.945
Human
forebrain development GO:0030900 302 0.945
synaptic transmission GO:0007268 329 0.939
regulation of binding GO:0051098 111 0.939
synapse organization GO:0050808 125 0.934
negative regulation of nervous system development GO:0051961 156 0.933
rna 3 end processing GO:0031123 20 0.932
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.932
dendrite development GO:0016358 115 0.930
inositol phosphate mediated signaling GO:0048016 13 0.928
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.926
learning or memory GO:0007611 148 0.921
plasma membrane organization GO:0007009 90 0.919
locomotory behavior GO:0007626 195 0.913
peptidyl tyrosine phosphorylation GO:0018108 143 0.906
response to radiation GO:0009314 165 0.902
axon cargo transport GO:0008088 33 0.901
ubiquitin dependent protein catabolic process GO:0006511 129 0.897
synaptic growth at neuromuscular junction GO:0051124 6 0.892
protein localization to membrane GO:0072657 108 0.890
regulation of protein kinase activity GO:0045859 232 0.889
regulation of endocytosis GO:0030100 69 0.884
membrane protein ectodomain proteolysis GO:0006509 7 0.880
midbrain development GO:0030901 35 0.874
Mouse
response to light stimulus GO:0009416 135 0.871
glutamate receptor signaling pathway GO:0007215 35 0.871
molting cycle GO:0042303 90 0.869
Worm
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.844
negative regulation of cell development GO:0010721 169 0.839
memory GO:0007613 58 0.838
Fly
forebrain cell migration GO:0021885 58 0.836
cell cell junction organization GO:0045216 72 0.836
telencephalon development GO:0021537 186 0.835
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.834
synaptic vesicle localization GO:0097479 59 0.817
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.812
cellular amine metabolic process GO:0044106 44 0.806
telencephalon cell migration GO:0022029 55 0.806
adult behavior GO:0030534 135 0.805
modification dependent macromolecule catabolic process GO:0043632 133 0.801
regulation of neuron projection development GO:0010975 169 0.796
positive regulation of apoptotic process GO:0043065 217 0.796
regulation of kinase activity GO:0043549 249 0.793
epidermal growth factor receptor signaling pathway GO:0007173 28 0.787
cell junction organization GO:0034330 77 0.771
synapse assembly GO:0007416 56 0.770
chemotaxis GO:0006935 247 0.760
positive regulation of neuron projection development GO:0010976 79 0.757
mating behavior GO:0007617 20 0.756
cytoskeleton dependent intracellular transport GO:0030705 50 0.755
regulation of erbb signaling pathway GO:1901184 16 0.746
regulation of cell migration GO:0030334 219 0.744
regulation of clathrin mediated endocytosis GO:2000369 4 0.742
extracellular structure organization GO:0043062 148 0.740
erbb signaling pathway GO:0038127 32 0.728
regulation of cellular ketone metabolic process GO:0010565 66 0.725
endocytosis GO:0006897 168 0.723
cellular protein catabolic process GO:0044257 155 0.714
translation GO:0006412 93 0.704
negative regulation of cellular component organization GO:0051129 194 0.701
neuron projection guidance GO:0097485 141 0.700
modification dependent protein catabolic process GO:0019941 133 0.696
ion transmembrane transport GO:0034220 361 0.687
regulation of cellular catabolic process GO:0031329 242 0.687
regulation of vesicle mediated transport GO:0060627 139 0.681
regulation of cellular amine metabolic process GO:0033238 20 0.674
cerebral cortex radially oriented cell migration GO:0021799 31 0.674
positive regulation of nervous system development GO:0051962 221 0.673
regulation of translation GO:0006417 71 0.666
organic hydroxy compound transport GO:0015850 93 0.665
protein processing GO:0016485 163 0.654
Human
calcineurin nfat signaling cascade GO:0033173 8 0.654
amyloid precursor protein metabolic process GO:0042982 13 0.654
cerebral cortex cell migration GO:0021795 44 0.639
cell growth GO:0016049 130 0.637
endomembrane system organization GO:0010256 147 0.637
regulation of cell motility GO:2000145 236 0.636
neuron maturation GO:0042551 29 0.632
regulation of receptor activity GO:0010469 41 0.630
axon guidance GO:0007411 141 0.626
apoptotic signaling pathway GO:0097190 306 0.626
cellular metal ion homeostasis GO:0006875 151 0.622
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 40 0.620
lipid transport GO:0006869 98 0.612
ensheathment of neurons GO:0007272 76 0.611
positive regulation of endocytosis GO:0045807 42 0.591
cell junction assembly GO:0034329 52 0.589
developmental cell growth GO:0048588 84 0.584
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.581
membrane protein proteolysis GO:0033619 10 0.570
mating GO:0007618 27 0.568
macromolecule glycosylation GO:0043413 55 0.568
establishment of synaptic vesicle localization GO:0097480 57 0.567
multi organism reproductive behavior GO:0044705 29 0.562
neuromuscular process controlling balance GO:0050885 59 0.560
protein localization to plasma membrane GO:0072659 57 0.560
hindbrain development GO:0030902 128 0.554
negative regulation of cell proliferation GO:0008285 296 0.553
neuron migration GO:0001764 122 0.552
cerebellum development GO:0021549 77 0.552
cellular amino acid metabolic process GO:0006520 103 0.550
regulation of apoptotic signaling pathway GO:2001233 197 0.549
cellular ion homeostasis GO:0006873 165 0.549
organic hydroxy compound metabolic process GO:1901615 203 0.547
glial cell differentiation GO:0010001 131 0.546
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.540
regulation of phospholipase a2 activity GO:0032429 3 0.539
developmental maturation GO:0021700 193 0.530
positive regulation of cell cycle phase transition GO:1901989 17 0.523
cell cell adhesion GO:0098609 41 0.522
multi organism behavior GO:0051705 62 0.519
cerebral cortex development GO:0021987 86 0.515
positive regulation of g2 m transition of mitotic cell cycle GO:0010971 5 0.515
feeding behavior GO:0007631 62 0.509
anion transport GO:0006820 177 0.509
positive regulation of cellular catabolic process GO:0031331 148 0.508
protein targeting to membrane GO:0006612 20 0.493
cellular ketone metabolic process GO:0042180 84 0.491
non canonical wnt signaling pathway GO:0035567 33 0.484
positive regulation of apoptotic signaling pathway GO:2001235 95 0.477
positive regulation of programmed cell death GO:0043068 218 0.469
mrna 3 end processing GO:0031124 16 0.467
adherens junction organization GO:0034332 28 0.464
notch signaling pathway GO:0007219 71 0.456
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.451
receptor recycling GO:0001881 11 0.441
posttranscriptional regulation of gene expression GO:0010608 155 0.438
mitotic cell cycle GO:0000278 195 0.437
visual behavior GO:0007632 45 0.437
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.435
cell maturation GO:0048469 127 0.435
neuron neuron synaptic transmission GO:0007270 69 0.425
neuronal action potential GO:0019228 54 0.425
regulation of mitotic cell cycle phase transition GO:1901990 73 0.423
cation transport GO:0006812 399 0.421
copper ion transport GO:0006825 10 0.420
positive regulation of cell development GO:0010720 237 0.415
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.414
regulation of transferase activity GO:0051338 263 0.412
metal ion homeostasis GO:0055065 189 0.407
cation homeostasis GO:0055080 212 0.407
establishment of protein localization to membrane GO:0090150 54 0.407
phospholipid transport GO:0015914 21 0.406
adult locomotory behavior GO:0008344 91 0.406
regulation of receptor recycling GO:0001919 8 0.405
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.403
protein catabolic process GO:0030163 221 0.403
developmental growth involved in morphogenesis GO:0060560 138 0.399
macromolecule catabolic process GO:0009057 281 0.385
negative regulation of phosphorylation GO:0042326 166 0.382
central nervous system neuron differentiation GO:0021953 162 0.376
protein modification by small protein conjugation GO:0032446 187 0.374
synaptic transmission glutamatergic GO:0035249 36 0.372
regulation of cell projection organization GO:0031344 206 0.370
plasma lipoprotein particle clearance GO:0034381 13 0.368
pallium development GO:0021543 120 0.365
cellular calcium ion homeostasis GO:0006874 119 0.365
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.360
negative regulation of cellular protein metabolic process GO:0032269 247 0.357
Human
single organismal cell cell adhesion GO:0016337 131 0.355
amine metabolic process GO:0009308 45 0.350
formation of radial glial scaffolds GO:0021943 4 0.349
lipid localization GO:0010876 126 0.348
segmentation GO:0035282 93 0.348
peptide metabolic process GO:0006518 46 0.348
negative regulation of phosphate metabolic process GO:0045936 184 0.346
skeletal system development GO:0001501 356 0.346
regulation of cell substrate adhesion GO:0010810 73 0.345
neuromuscular process GO:0050905 99 0.340
regulation of mitotic cell cycle GO:0007346 126 0.339
cholesterol transport GO:0030301 38 0.338
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.335
cell fate commitment GO:0045165 210 0.334
tube formation GO:0035148 140 0.333
coagulation GO:0050817 78 0.332
myeloid cell homeostasis GO:0002262 114 0.331
epithelial tube morphogenesis GO:0060562 303 0.330
establishment of vesicle localization GO:0051650 81 0.330
receptor mediated endocytosis GO:0006898 51 0.327
transmembrane transport GO:0055085 412 0.327
positive regulation of growth GO:0045927 104 0.321
Worm
dendritic spine development GO:0060996 30 0.320
regulation of protein stability GO:0031647 52 0.318
peptidyl amino acid modification GO:0018193 336 0.318
glycoprotein metabolic process GO:0009100 116 0.316
social behavior GO:0035176 21 0.312
positive regulation of neuron differentiation GO:0045666 141 0.310
response to organic cyclic compound GO:0014070 198 0.296
sterol homeostasis GO:0055092 45 0.295
blood vessel morphogenesis GO:0048514 285 0.294
cellular transition metal ion homeostasis GO:0046916 32 0.293
positive regulation of protein kinase activity GO:0045860 144 0.290
nitrogen compound transport GO:0071705 271 0.284
embryonic limb morphogenesis GO:0030326 126 0.281
regulation of protein processing GO:0070613 96 0.281
Human
vesicle localization GO:0051648 86 0.280
regulation of cellular protein catabolic process GO:1903362 61 0.278
positive regulation of cell death GO:0010942 224 0.274
regulation of postsynaptic membrane potential GO:0060078 48 0.269
glycoprotein biosynthetic process GO:0009101 89 0.266
pole plasm assembly GO:0007315 2 0.265
peripheral nervous system development GO:0007422 53 0.260
Fly
positive regulation of transferase activity GO:0051347 167 0.257
gliogenesis GO:0042063 141 0.254
leukocyte migration GO:0050900 124 0.252
choline transport GO:0015871 3 0.252
cellular amide metabolic process GO:0043603 58 0.249
regulation of synaptic transmission glutamatergic GO:0051966 19 0.247
regulation of cell cycle GO:0051726 281 0.245
lateral inhibition GO:0046331 1 0.245
purine containing compound metabolic process GO:0072521 311 0.244
striated muscle tissue development GO:0014706 293 0.243
positive regulation of cell cycle GO:0045787 92 0.242
morphogenesis of embryonic epithelium GO:0016331 159 0.242
organelle localization GO:0051640 179 0.241
metencephalon development GO:0022037 89 0.238
appendage development GO:0048736 166 0.238
adherens junction assembly GO:0034333 22 0.236
cellular response to growth factor stimulus GO:0071363 197 0.233
forebrain generation of neurons GO:0021872 63 0.230
axon ensheathment GO:0008366 76 0.230
heart morphogenesis GO:0003007 178 0.226
ribose phosphate metabolic process GO:0019693 291 0.226
regulation of synaptic plasticity GO:0048167 87 0.226
proteasomal protein catabolic process GO:0010498 98 0.224
cell cycle arrest GO:0007050 37 0.222
meiotic nuclear division GO:0007126 115 0.221
embryonic appendage morphogenesis GO:0035113 126 0.219
limb morphogenesis GO:0035108 149 0.218
regulation of ion transport GO:0043269 215 0.217
layer formation in cerebral cortex GO:0021819 13 0.214
mesoderm development GO:0007498 100 0.212
asymmetric neuroblast division GO:0055059 1 0.212
monoamine transport GO:0015844 33 0.211
regionalization GO:0003002 337 0.210
single organism cell adhesion GO:0098602 156 0.207
somatic stem cell division GO:0048103 19 0.206
hindbrain radial glia guided cell migration GO:0021932 12 0.203
positive regulation of kinase activity GO:0033674 155 0.201
embryonic epithelial tube formation GO:0001838 130 0.200
negative regulation of activated t cell proliferation GO:0046007 7 0.200
regulation of protein binding GO:0043393 60 0.199
negative regulation of interleukin 2 production GO:0032703 8 0.199
cardiac muscle tissue development GO:0048738 130 0.197
adherens junction maintenance GO:0034334 1 0.196
mrna processing GO:0006397 63 0.193
negative regulation of neuron death GO:1901215 98 0.192
Fly
extrinsic apoptotic signaling pathway GO:0097191 126 0.190
protein localization to juxtaparanode region of axon GO:0071205 4 0.189
axon transport of mitochondrion GO:0019896 2 0.187
positive regulation of substrate adhesion dependent cell spreading GO:1900026 8 0.187
asymmetric stem cell division GO:0098722 3 0.186
notch receptor processing GO:0007220 4 0.186
stem cell differentiation GO:0048863 268 0.185
reproductive behavior GO:0019098 32 0.185
activation of mapkk activity GO:0000186 15 0.184
negative regulation of protein catabolic process GO:0042177 36 0.184
response to oxidative stress GO:0006979 123 0.183
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.182
embryonic heart tube development GO:0035050 65 0.181
negative regulation of molecular function GO:0044092 258 0.177
Human
positive regulation of cell migration GO:0030335 109 0.177
purine ribonucleoside metabolic process GO:0046128 241 0.174
alcohol metabolic process GO:0006066 116 0.174
beta amyloid metabolic process GO:0050435 14 0.172
mesenchyme development GO:0060485 152 0.172
neuron recognition GO:0008038 25 0.169
glycosylation GO:0070085 62 0.168
cell recognition GO:0008037 83 0.168
intrinsic apoptotic signaling pathway GO:0097193 132 0.167
multicellular organismal response to stress GO:0033555 62 0.165
meiotic cell cycle GO:0051321 122 0.165
cellular protein complex assembly GO:0043623 116 0.164
establishment of glial blood brain barrier GO:0060857 2 0.164
ribonucleotide catabolic process GO:0009261 208 0.163
purine nucleotide metabolic process GO:0006163 302 0.163
protein modification by small protein conjugation or removal GO:0070647 207 0.163
negative regulation of neuron projection development GO:0010977 50 0.162
wnt signaling pathway GO:0016055 188 0.162
positive regulation of cell projection organization GO:0031346 95 0.161
multicellular organism growth GO:0035264 161 0.160
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.160
cellular divalent inorganic cation homeostasis GO:0072503 127 0.159
long term memory GO:0007616 15 0.159
Fly
substrate adhesion dependent cell spreading GO:0034446 30 0.155
regulation of chemotaxis GO:0050920 53 0.154
positive regulation of cell adhesion GO:0045785 80 0.154
negative regulation of cell motility GO:2000146 61 0.154
neural tube development GO:0021915 160 0.152
positive regulation of mitotic cell cycle GO:0045931 41 0.151
ossification GO:0001503 216 0.150
negative regulation of cell migration GO:0030336 59 0.150
regulation of membrane potential GO:0042391 192 0.150
autophagic vacuole assembly GO:0000045 13 0.149
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.148
regulation of cellular response to stress GO:0080135 159 0.147
organophosphate ester transport GO:0015748 28 0.146
embryonic hindlimb morphogenesis GO:0035116 32 0.144
intracellular cholesterol transport GO:0032367 3 0.144
cellularization GO:0007349 1 0.143
terminal button organization GO:0072553 3 0.142
epithelial cell development GO:0002064 159 0.139
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.138
regulation of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor activity GO:2000311 11 0.138
establishment of blood brain barrier GO:0060856 8 0.138
central nervous system neuron development GO:0021954 67 0.138
establishment of organelle localization GO:0051656 122 0.137
positive regulation of cell motility GO:2000147 116 0.135
negative regulation of immune system process GO:0002683 209 0.135
regulation of glutamate receptor signaling pathway GO:1900449 16 0.133
camera type eye development GO:0043010 266 0.132
muscle cell fate specification GO:0042694 1 0.131
synaptic transmission gabaergic GO:0051932 19 0.131
positive regulation of lipid transport GO:0032370 22 0.131
cell chemotaxis GO:0060326 81 0.130
regulation of cell growth GO:0001558 91 0.130
positive regulation of cellular protein catabolic process GO:1903364 34 0.128
bone development GO:0060348 120 0.128
protein maturation GO:0051604 176 0.128
Human
cell substrate adhesion GO:0031589 130 0.127
microtubule based movement GO:0007018 84 0.126
positive regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000060 8 0.126
somitogenesis GO:0001756 69 0.126
cellular chemical homeostasis GO:0055082 215 0.122
muscle tissue development GO:0060537 308 0.122
negative regulation of cell projection organization GO:0031345 56 0.122
regulation of protein localization GO:0032880 231 0.121
membrane organization GO:0061024 245 0.121
t cell proliferation GO:0042098 120 0.119
cerebral cortex radial glia guided migration GO:0021801 17 0.119
response to growth factor GO:0070848 198 0.119
neuron remodeling GO:0016322 7 0.119
positive regulation of secretion by cell GO:1903532 114 0.119
neuron death GO:0070997 154 0.119
digestive tract morphogenesis GO:0048546 147 0.119
negative regulation of planar cell polarity pathway involved in pericardium morphogenesis GO:2000166 1 0.118
negative regulation of proteolysis GO:0045861 74 0.118
Human
regulation of protein serine threonine kinase activity GO:0071900 157 0.116
epithelial tube formation GO:0072175 130 0.115
negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000164 1 0.114
glial cell migration GO:0008347 7 0.114
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 10 0.113
leukocyte chemotaxis GO:0030595 69 0.112
negative regulation of cell cycle GO:0045786 123 0.112
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.112
embryonic digit morphogenesis GO:0042733 56 0.110
anatomical structure homeostasis GO:0060249 145 0.110
mapk cascade GO:0000165 281 0.110
rho protein signal transduction GO:0007266 32 0.108
intracellular protein transport GO:0006886 204 0.108
sterol transport GO:0015918 38 0.108
cellular biogenic amine metabolic process GO:0006576 28 0.107
cholesterol homeostasis GO:0042632 44 0.107
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.107
response to transforming growth factor beta GO:0071559 88 0.107
negative regulation of ubiquitin protein transferase activity GO:0051444 3 0.107
regulation of organ morphogenesis GO:2000027 144 0.106
appendage morphogenesis GO:0035107 149 0.104
leukocyte proliferation GO:0070661 172 0.104
cell migration involved in gastrulation GO:0042074 13 0.104
positive regulation of receptor mediated endocytosis GO:0048260 9 0.104
myeloid leukocyte migration GO:0097529 57 0.103
synaptic vesicle transport GO:0048489 57 0.103
dna metabolic process GO:0006259 303 0.103
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.103
amyloid precursor protein biosynthetic process GO:0042983 3 0.102
positive regulation of dendrite development GO:1900006 21 0.102
purine ribonucleotide metabolic process GO:0009150 290 0.102
cellular response to external stimulus GO:0071496 88 0.101
negative regulation of protein phosphorylation GO:0001933 126 0.100
regulation of mapk cascade GO:0043408 248 0.100
negative regulation of glycoprotein biosynthetic process GO:0010561 3 0.100
negative regulation of calcium mediated signaling GO:0050849 2 0.099
embryonic heart tube morphogenesis GO:0003143 51 0.099
embryonic organ morphogenesis GO:0048562 276 0.099
intraspecies interaction between organisms GO:0051703 21 0.099
positive regulation of protein phosphorylation GO:0001934 242 0.099
response to amino acid GO:0043200 37 0.099
digestive system development GO:0055123 200 0.098
divalent inorganic cation homeostasis GO:0072507 138 0.098
regulation of hydrolase activity GO:0051336 246 0.098
Human Rat
regulation of non canonical wnt signaling pathway GO:2000050 12 0.098
negative regulation of apoptotic signaling pathway GO:2001234 104 0.097
cell fate specification GO:0001708 72 0.097
regulation of calcineurin nfat signaling cascade GO:0070884 5 0.097
regulation of establishment of planar polarity GO:0090175 28 0.097
ventricular system development GO:0021591 27 0.096
neuroblast division GO:0055057 10 0.096
olfactory learning GO:0008355 2 0.096
cartilage development GO:0051216 140 0.096
protein targeting GO:0006605 143 0.096
regulation of map kinase activity GO:0043405 120 0.095
gland development GO:0048732 330 0.094
response to metal ion GO:0010038 47 0.094
activation of transmembrane receptor protein tyrosine kinase activity GO:0007171 3 0.093
apical junction assembly GO:0043297 15 0.092
clathrin mediated endocytosis GO:0072583 7 0.091
negative regulation of protein maturation GO:1903318 79 0.091
Human
response to drug GO:0042493 75 0.090
angiogenesis GO:0001525 201 0.090
amino acid transport GO:0006865 61 0.090
carbohydrate derivative catabolic process GO:1901136 231 0.090
positive regulation of secretion GO:0051047 130 0.089
negative regulation of phosphorus metabolic process GO:0010563 184 0.089
cell substrate junction assembly GO:0007044 24 0.088
calcium ion transmembrane transport GO:0070588 85 0.088
l amino acid transport GO:0015807 32 0.087
negative regulation of platelet derived growth factor receptor beta signaling pathway GO:2000587 2 0.086
insulin metabolic process GO:1901142 3 0.085
beta amyloid clearance GO:0097242 2 0.085
stem cell division GO:0017145 30 0.085
cation transmembrane transport GO:0098655 266 0.085
t cell activation GO:0042110 289 0.084
intracellular lipid transport GO:0032365 3 0.084
regulation of cell cycle process GO:0010564 160 0.084
regulation of planar cell polarity pathway involved in outflow tract morphogenesis GO:2000163 1 0.084
positive regulation of protein modification process GO:0031401 299 0.084
regulation of cell adhesion GO:0030155 154 0.083
gastrulation GO:0007369 116 0.082
regulation of amyloid precursor protein biosynthetic process GO:0042984 3 0.081
positive regulation of proteolysis GO:0045862 85 0.081
Rat
midgut development GO:0007494 4 0.081
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.080
limb development GO:0060173 166 0.080
positive regulation of glutamate secretion GO:0014049 2 0.080
cellular response to starvation GO:0009267 57 0.079
positive regulation of mapk cascade GO:0043410 170 0.079
wnt signaling pathway planar cell polarity pathway GO:0060071 27 0.078
regulation of establishment of protein localization GO:0070201 181 0.078
alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate selective glutamate receptor clustering GO:0097113 3 0.078
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.078
primary neural tube formation GO:0014020 95 0.077
positive regulation of protein catabolic process GO:0045732 60 0.077
negative regulation of erbb signaling pathway GO:1901185 7 0.077
divalent inorganic cation transport GO:0072511 178 0.077
nucleobase containing small molecule metabolic process GO:0055086 352 0.077
cell cycle g2 m phase transition GO:0044839 20 0.076
nucleoside metabolic process GO:0009116 246 0.076
negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis GO:2000149 1 0.076
cellular homeostasis GO:0019725 240 0.075
cellular response to dna damage stimulus GO:0006974 207 0.075
neuron apoptotic process GO:0051402 142 0.075
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.074
negative regulation of cellular catabolic process GO:0031330 47 0.074
regulation of intracellular transport GO:0032386 159 0.073
organic anion transport GO:0015711 137 0.073
extracellular matrix organization GO:0030198 147 0.072
oocyte anterior posterior axis specification GO:0007314 2 0.072
cellular macromolecule catabolic process GO:0044265 206 0.072
hindbrain morphogenesis GO:0021575 46 0.072
dicarboxylic acid transport GO:0006835 29 0.071
rna processing GO:0006396 105 0.071
maternal determination of anterior posterior axis embryo GO:0008358 2 0.071
vacuole organization GO:0007033 38 0.070
forebrain neuron development GO:0021884 30 0.070
action potential GO:0001508 78 0.070
negative regulation of glial cell differentiation GO:0045686 21 0.070
regulation of notch signaling pathway GO:0008593 35 0.070
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.070
outflow tract morphogenesis GO:0003151 53 0.070

App disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.941
Human
nervous system disease DOID:863 0 0.941
Human
disease of metabolism DOID:0014667 0 0.891
Human
acquired metabolic disease DOID:0060158 0 0.891
Human
central nervous system disease DOID:331 0 0.576
Human
brain disease DOID:936 0 0.426
disease of mental health DOID:150 0 0.311
Human
cognitive disorder DOID:1561 0 0.258
Human
dementia DOID:1307 0 0.190
Human
alzheimer s disease DOID:10652 0 0.190
Human
tauopathy DOID:680 0 0.190
Human
neurodegenerative disease DOID:1289 0 0.190
Human
amyloidosis DOID:9120 0 0.121
Human
immune system disease DOID:2914 0 0.100
lymphatic system disease DOID:75 0 0.100
epilepsy syndrome DOID:1826 0 0.099
electroclinical syndrome DOID:0050701 0 0.099
integumentary system disease DOID:16 0 0.099
inherited metabolic disorder DOID:655 0 0.090