Mus musculus

0 known processes

Appl2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

(Aliases: Dip3b)

Appl2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 103 0.091
cellular ketone metabolic process GO:0042180 84 0.070
regulation of cellular amino acid metabolic process GO:0006521 5 0.067
cellular amine metabolic process GO:0044106 44 0.066
negative regulation of cellular protein metabolic process GO:0032269 247 0.064
histone lysine methylation GO:0034968 50 0.054
peptidyl amino acid modification GO:0018193 336 0.051
nucleobase containing small molecule metabolic process GO:0055086 352 0.051
response to peptide hormone GO:0043434 127 0.050
actin cytoskeleton organization GO:0030036 220 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.047
amine metabolic process GO:0009308 45 0.045
organelle localization GO:0051640 179 0.043
regionalization GO:0003002 337 0.042
negative regulation of cellular component organization GO:0051129 194 0.042
response to organonitrogen compound GO:0010243 246 0.041
regulation of apoptotic signaling pathway GO:2001233 197 0.040
cellular nitrogen compound catabolic process GO:0044270 280 0.038
carbohydrate metabolic process GO:0005975 230 0.038
reactive oxygen species metabolic process GO:0072593 84 0.038
dna metabolic process GO:0006259 303 0.038
urogenital system development GO:0001655 261 0.038
dephosphorylation GO:0016311 129 0.038
cation transport GO:0006812 399 0.037
primary neural tube formation GO:0014020 95 0.037
posttranscriptional regulation of gene expression GO:0010608 155 0.037
embryonic epithelial tube formation GO:0001838 130 0.037
regulation of reactive oxygen species metabolic process GO:2000377 40 0.036
cell type specific apoptotic process GO:0097285 268 0.036
stem cell development GO:0048864 219 0.035
negative regulation of protein metabolic process GO:0051248 282 0.035
cellular response to cytokine stimulus GO:0071345 189 0.034
cellular response to hormone stimulus GO:0032870 150 0.032
small gtpase mediated signal transduction GO:0007264 97 0.032
cellular carbohydrate metabolic process GO:0044262 119 0.032
cellular lipid metabolic process GO:0044255 323 0.032
nucleotide metabolic process GO:0009117 332 0.032
locomotory behavior GO:0007626 195 0.032
synaptic transmission GO:0007268 329 0.032
cellular macromolecule catabolic process GO:0044265 206 0.031
g protein coupled receptor signaling pathway GO:0007186 243 0.031
cellular response to organonitrogen compound GO:0071417 145 0.031
establishment of organelle localization GO:0051656 122 0.030
regulation of organelle organization GO:0033043 289 0.030
cellular protein complex assembly GO:0043623 116 0.030
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.030
regulation of cellular amine metabolic process GO:0033238 20 0.030
purine nucleoside metabolic process GO:0042278 241 0.030
positive regulation of protein modification process GO:0031401 299 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.029
positive regulation of apoptotic process GO:0043065 217 0.029
positive regulation of cellular amine metabolic process GO:0033240 5 0.029
regulation of hydrolase activity GO:0051336 246 0.028
organophosphate catabolic process GO:0046434 232 0.028
cellular response to dna damage stimulus GO:0006974 207 0.028
guanosine containing compound catabolic process GO:1901069 144 0.027
negative regulation of nervous system development GO:0051961 156 0.027
chromatin organization GO:0006325 206 0.027
vesicle localization GO:0051648 86 0.027
homeostasis of number of cells GO:0048872 210 0.027
cytokine production GO:0001816 319 0.026
organonitrogen compound catabolic process GO:1901565 264 0.026
regulation of intracellular transport GO:0032386 159 0.026
male gamete generation GO:0048232 285 0.026
glucose homeostasis GO:0042593 128 0.026
regulation of cell activation GO:0050865 289 0.025
maintenance of location GO:0051235 89 0.025
chromatin modification GO:0016568 187 0.025
ribonucleoside metabolic process GO:0009119 245 0.025
phospholipid biosynthetic process GO:0008654 36 0.025
hexose metabolic process GO:0019318 98 0.025
regulation of protein localization GO:0032880 231 0.025
compound eye development GO:0048749 1 0.024
ribonucleoside catabolic process GO:0042454 206 0.024
epithelial tube morphogenesis GO:0060562 303 0.024
regulation of transferase activity GO:0051338 263 0.024
heterocycle catabolic process GO:0046700 280 0.024
response to light stimulus GO:0009416 135 0.023
positive regulation of gtp catabolic process GO:0033126 85 0.023
renal system development GO:0072001 225 0.023
negative regulation of protein modification process GO:0031400 163 0.023
regulation of membrane potential GO:0042391 192 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
regulation of lymphocyte activation GO:0051249 240 0.022
cellular response to organic cyclic compound GO:0071407 87 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
positive regulation of cell death GO:0010942 224 0.022
ras protein signal transduction GO:0007265 77 0.022
purine nucleoside triphosphate metabolic process GO:0009144 226 0.021
neural tube formation GO:0001841 108 0.021
purine nucleotide metabolic process GO:0006163 302 0.021
peptidyl tyrosine modification GO:0018212 145 0.021
macromolecule catabolic process GO:0009057 281 0.021
transmembrane transport GO:0055085 412 0.021
regulation of cellular component biogenesis GO:0044087 181 0.020
ribonucleotide metabolic process GO:0009259 291 0.020
negative regulation of cell proliferation GO:0008285 296 0.020
regulation of homeostatic process GO:0032844 182 0.020
organic cyclic compound catabolic process GO:1901361 295 0.020
aromatic compound catabolic process GO:0019439 286 0.020
muscle cell differentiation GO:0042692 261 0.020
microtubule based process GO:0007017 236 0.020
rna processing GO:0006396 105 0.020
rhythmic process GO:0048511 174 0.020
lipid biosynthetic process GO:0008610 179 0.020
positive regulation of organelle organization GO:0010638 128 0.019
purine containing compound metabolic process GO:0072521 311 0.019
protein modification by small protein conjugation or removal GO:0070647 207 0.019
cytokine mediated signaling pathway GO:0019221 115 0.019
carbohydrate derivative biosynthetic process GO:1901137 183 0.019
embryonic organ morphogenesis GO:0048562 276 0.019
inorganic ion transmembrane transport GO:0098660 234 0.019
purine nucleoside catabolic process GO:0006152 205 0.019
divalent inorganic cation transport GO:0072511 178 0.019
protein catabolic process GO:0030163 221 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
positive regulation of programmed cell death GO:0043068 218 0.019
positive regulation of nervous system development GO:0051962 221 0.019
nucleoside phosphate metabolic process GO:0006753 338 0.019
membrane organization GO:0061024 245 0.018
gland development GO:0048732 330 0.018
generation of precursor metabolites and energy GO:0006091 103 0.018
apoptotic signaling pathway GO:0097190 306 0.018
cellular response to lipid GO:0071396 145 0.018
mitotic cell cycle GO:0000278 195 0.018
digestive system development GO:0055123 200 0.018
regulation of cytokine production GO:0001817 266 0.018
methylation GO:0032259 134 0.018
peptidyl tyrosine phosphorylation GO:0018108 143 0.018
negative regulation of cell development GO:0010721 169 0.018
dna repair GO:0006281 107 0.018
glycosyl compound catabolic process GO:1901658 206 0.018
leukocyte differentiation GO:0002521 342 0.018
regulation of cellular catabolic process GO:0031329 242 0.018
nucleotide catabolic process GO:0009166 217 0.018
myeloid cell differentiation GO:0030099 233 0.018
positive regulation of protein catabolic process GO:0045732 60 0.017
cytoplasmic transport GO:0016482 234 0.017
response to inorganic substance GO:0010035 96 0.017
response to oxygen levels GO:0070482 62 0.017
negative regulation of organelle organization GO:0010639 90 0.017
response to organic cyclic compound GO:0014070 198 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.017
tube formation GO:0035148 140 0.017
glycerophospholipid metabolic process GO:0006650 71 0.017
regulation of cell cycle GO:0051726 281 0.017
regulation of anatomical structure size GO:0090066 178 0.017
spermatid differentiation GO:0048515 115 0.017
nucleoside phosphate catabolic process GO:1901292 222 0.017
organophosphate biosynthetic process GO:0090407 122 0.017
establishment of vesicle localization GO:0051650 81 0.017
regulation of protein complex assembly GO:0043254 83 0.017
stem cell differentiation GO:0048863 268 0.017
ribose phosphate metabolic process GO:0019693 291 0.017
inorganic cation transmembrane transport GO:0098662 207 0.017
exocytosis GO:0006887 121 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
regulation of protein serine threonine kinase activity GO:0071900 157 0.017
ribonucleotide catabolic process GO:0009261 208 0.017
protein targeting GO:0006605 143 0.016
cation transmembrane transport GO:0098655 266 0.016
circulatory system process GO:0003013 197 0.016
actin filament organization GO:0007015 113 0.016
ion transmembrane transport GO:0034220 361 0.016
purine ribonucleotide metabolic process GO:0009150 290 0.016
carbohydrate homeostasis GO:0033500 128 0.016
glycoprotein metabolic process GO:0009100 116 0.016
action potential GO:0001508 78 0.016
kidney development GO:0001822 213 0.016
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
response to peptide GO:1901652 136 0.016
spermatogenesis GO:0007283 284 0.016
regulation of cytoskeleton organization GO:0051493 122 0.016
muscle tissue development GO:0060537 308 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
cell adhesion GO:0007155 329 0.016
oxidation reduction process GO:0055114 342 0.015
positive regulation of cellular catabolic process GO:0031331 148 0.015
regulation of secretion GO:0051046 274 0.015
regulation of metal ion transport GO:0010959 106 0.015
cellular response to lipopolysaccharide GO:0071222 77 0.015
cellular response to molecule of bacterial origin GO:0071219 83 0.015
purine ribonucleoside metabolic process GO:0046128 241 0.015
intracellular protein transport GO:0006886 204 0.015
sensory perception GO:0007600 245 0.015
tissue homeostasis GO:0001894 115 0.015
protein ubiquitination GO:0016567 171 0.015
t cell activation GO:0042110 289 0.015
chemotaxis GO:0006935 247 0.015
nitrogen compound transport GO:0071705 271 0.015
regulation of neuron differentiation GO:0045664 281 0.015
negative regulation of mitotic cell cycle GO:0045930 58 0.015
hormone mediated signaling pathway GO:0009755 23 0.015
viral gene expression GO:0019080 3 0.015
neuronal action potential GO:0019228 54 0.015
regulation of vesicle mediated transport GO:0060627 139 0.015
histone h2a ubiquitination GO:0033522 3 0.015
positive regulation of cell adhesion GO:0045785 80 0.014
axonogenesis GO:0007409 274 0.014
neuron death GO:0070997 154 0.014
regulation of t cell activation GO:0050863 170 0.014
mapk cascade GO:0000165 281 0.014
germ cell development GO:0007281 185 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
regulation of neuron death GO:1901214 134 0.014
positive regulation of leukocyte differentiation GO:1902107 86 0.014
regulation of nucleoside metabolic process GO:0009118 130 0.014
positive regulation of nucleoside metabolic process GO:0045979 91 0.014
cellular chemical homeostasis GO:0055082 215 0.014
carbohydrate derivative catabolic process GO:1901136 231 0.014
regulation of gtp catabolic process GO:0033124 113 0.014
negative regulation of cell cycle GO:0045786 123 0.014
regulation of ion transport GO:0043269 215 0.014
negative regulation of cellular amine metabolic process GO:0033239 1 0.014
protein localization to membrane GO:0072657 108 0.014
regulation of mapk cascade GO:0043408 248 0.014
negative regulation of phosphate metabolic process GO:0045936 184 0.014
leukocyte mediated immunity GO:0002443 174 0.014
neural tube closure GO:0001843 90 0.013
cellular homeostasis GO:0019725 240 0.013
organic hydroxy compound metabolic process GO:1901615 203 0.013
multicellular organism growth GO:0035264 161 0.013
response to nutrient levels GO:0031667 109 0.013
cellular response to biotic stimulus GO:0071216 92 0.013
regulation of cell cycle process GO:0010564 160 0.013
regulation of secretion by cell GO:1903530 249 0.013
nucleoside metabolic process GO:0009116 246 0.013
cytoskeleton dependent intracellular transport GO:0030705 50 0.013
regulation of proteolysis GO:0030162 164 0.013
actin filament polymerization GO:0030041 44 0.013
wnt signaling pathway GO:0016055 188 0.013
rna catabolic process GO:0006401 29 0.013
cation homeostasis GO:0055080 212 0.013
protein maturation GO:0051604 176 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
regulation of cell adhesion GO:0030155 154 0.013
regulation of kinase activity GO:0043549 249 0.013
regulation of protein transport GO:0051223 163 0.013
regulation of protein catabolic process GO:0042176 108 0.013
immune effector process GO:0002252 321 0.013
notch signaling pathway GO:0007219 71 0.013
plasma membrane organization GO:0007009 90 0.013
multicellular organismal homeostasis GO:0048871 164 0.012
dorsal ventral axon guidance GO:0033563 3 0.012
rho protein signal transduction GO:0007266 32 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
positive regulation of cell motility GO:2000147 116 0.012
nucleoside catabolic process GO:0009164 206 0.012
positive regulation of neuron differentiation GO:0045666 141 0.012
response to radiation GO:0009314 165 0.012
dendrite development GO:0016358 115 0.012
regulation of excitatory postsynaptic membrane potential GO:0060079 41 0.012
lipid localization GO:0010876 126 0.012
protein processing GO:0016485 163 0.012
covalent chromatin modification GO:0016569 163 0.012
epithelial tube formation GO:0072175 130 0.012
negative regulation of molecular function GO:0044092 258 0.012
spermatid development GO:0007286 108 0.012
gtp metabolic process GO:0046039 144 0.012
morphogenesis of embryonic epithelium GO:0016331 159 0.012
glucose metabolic process GO:0006006 92 0.012
myeloid cell homeostasis GO:0002262 114 0.012
positive regulation of apoptotic signaling pathway GO:2001235 95 0.012
regulation of lymphocyte differentiation GO:0045619 107 0.012
mitotic cell cycle process GO:1903047 159 0.012
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.012
carbon catabolite activation of transcription GO:0045991 4 0.012
extracellular structure organization GO:0043062 148 0.012
regulation of cellular component size GO:0032535 121 0.012
cellular ion homeostasis GO:0006873 165 0.012
regulation of carbohydrate metabolic process GO:0006109 75 0.012
cell recognition GO:0008037 83 0.012
negative regulation of immune system process GO:0002683 209 0.012
carbon catabolite regulation of transcription GO:0045990 4 0.012
regulation of protein kinase activity GO:0045859 232 0.012
smoothened signaling pathway GO:0007224 105 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
epithelial cell proliferation GO:0050673 174 0.012
divalent metal ion transport GO:0070838 172 0.012
cell cell recognition GO:0009988 44 0.012
cellular response to nutrient levels GO:0031669 64 0.012
positive regulation of cell development GO:0010720 237 0.012
digestive tract development GO:0048565 190 0.012
purine ribonucleoside catabolic process GO:0046130 205 0.012
response to growth factor GO:0070848 198 0.012
learning or memory GO:0007611 148 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.011
microtubule based transport GO:0010970 50 0.011
purine ribonucleotide catabolic process GO:0009154 208 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
protein localization to plasma membrane GO:0072659 57 0.011
negative regulation of neuron differentiation GO:0045665 101 0.011
adult behavior GO:0030534 135 0.011
anatomical structure homeostasis GO:0060249 145 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
mitochondrion organization GO:0007005 134 0.011
transmission of nerve impulse GO:0019226 76 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
response to uv GO:0009411 44 0.011
endocytosis GO:0006897 168 0.011
positive regulation of hydrolase activity GO:0051345 148 0.011
lateral inhibition GO:0046331 1 0.011
sequestering of metal ion GO:0051238 19 0.011
positive regulation of nucleotide catabolic process GO:0030813 88 0.011
energy derivation by oxidation of organic compounds GO:0015980 77 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
regulation of actin filament based process GO:0032970 99 0.011
regulation of ras gtpase activity GO:0032318 88 0.011
myeloid leukocyte differentiation GO:0002573 119 0.011
blood circulation GO:0008015 195 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.011
carbohydrate biosynthetic process GO:0016051 74 0.011
histone modification GO:0016570 159 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
neuromuscular process controlling balance GO:0050885 59 0.011
regulation of transcription from rna polymerase iii promoter GO:0006359 2 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.010
cellular metal ion homeostasis GO:0006875 151 0.010
protein methylation GO:0006479 81 0.010
neuron apoptotic process GO:0051402 142 0.010
anion transport GO:0006820 177 0.010
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.010
guanosine containing compound metabolic process GO:1901068 144 0.010
small molecule catabolic process GO:0044282 71 0.010
carboxylic acid transport GO:0046942 100 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
translation GO:0006412 93 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
multicellular organismal signaling GO:0035637 91 0.010
regulation of feeding behavior GO:0060259 3 0.010
bmp signaling pathway GO:0030509 93 0.010
muscle system process GO:0003012 141 0.010
adaptive immune response GO:0002250 155 0.010
negative regulation of cytokine production GO:0001818 84 0.010
multi multicellular organism process GO:0044706 109 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
regulation of lipid metabolic process GO:0019216 118 0.010
single fertilization GO:0007338 82 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
polysaccharide metabolic process GO:0005976 39 0.010

Appl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.037
inherited metabolic disorder DOID:655 0 0.022
disease of anatomical entity DOID:7 0 0.017
nervous system disease DOID:863 0 0.017
organ system cancer DOID:0050686 0 0.015
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
central nervous system disease DOID:331 0 0.013