Mus musculus

99 known processes

Calr

calreticulin

(Aliases: Calregulin,CRT)

Calr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to endoplasmic reticulum stress GO:0034976 53 0.292
Worm
response to topologically incorrect protein GO:0035966 25 0.247
Worm
apoptotic signaling pathway GO:0097190 306 0.228
er nucleus signaling pathway GO:0006984 27 0.226
Worm
glycoprotein biosynthetic process GO:0009101 89 0.222
cellular response to topologically incorrect protein GO:0035967 25 0.217
Worm
spermatogenesis GO:0007283 284 0.194
Rat
protein glycosylation GO:0006486 55 0.163
proteasomal protein catabolic process GO:0010498 98 0.151
protein hydroxylation GO:0018126 4 0.148
peptidyl amino acid modification GO:0018193 336 0.146
endoplasmic reticulum unfolded protein response GO:0030968 19 0.144
Worm
cellular amino acid metabolic process GO:0006520 103 0.139
regulation of apoptotic signaling pathway GO:2001233 197 0.127
macromolecule glycosylation GO:0043413 55 0.122
endocytosis GO:0006897 168 0.119
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.115
glycoprotein metabolic process GO:0009100 116 0.110
protein n linked glycosylation GO:0006487 12 0.106
transmembrane transport GO:0055085 412 0.105
peptidyl proline hydroxylation to 4 hydroxy l proline GO:0018401 2 0.095
lateral inhibition GO:0046331 1 0.091
male gamete generation GO:0048232 285 0.087
Rat
modification dependent protein catabolic process GO:0019941 133 0.075
cellular protein catabolic process GO:0044257 155 0.074
extrinsic apoptotic signaling pathway GO:0097191 126 0.073
glycosylation GO:0070085 62 0.073
spermatid differentiation GO:0048515 115 0.072
positive regulation of cell death GO:0010942 224 0.071
carbohydrate derivative biosynthetic process GO:1901137 183 0.071
positive regulation of programmed cell death GO:0043068 218 0.068
alpha amino acid metabolic process GO:1901605 59 0.066
spermatid development GO:0007286 108 0.064
4 hydroxyproline metabolic process GO:0019471 5 0.064
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.063
regulation of cellular amino acid metabolic process GO:0006521 5 0.060
amine metabolic process GO:0009308 45 0.059
cellular macromolecule catabolic process GO:0044265 206 0.059
response to unfolded protein GO:0006986 21 0.058
Worm
posttranscriptional regulation of gene expression GO:0010608 155 0.058
cation homeostasis GO:0055080 212 0.058
regulation of cellular response to stress GO:0080135 159 0.057
regulation of transferase activity GO:0051338 263 0.056
body morphogenesis GO:0010171 45 0.055
germ cell development GO:0007281 185 0.052
protein catabolic process GO:0030163 221 0.052
cellular amine metabolic process GO:0044106 44 0.052
modification dependent macromolecule catabolic process GO:0043632 133 0.052
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.051
digestive tract development GO:0048565 190 0.050
regulation of cell migration GO:0030334 219 0.048
Human
carbohydrate metabolic process GO:0005975 230 0.047
circulatory system process GO:0003013 197 0.047
vascular process in circulatory system GO:0003018 62 0.046
regulation of cellular ketone metabolic process GO:0010565 66 0.042
regulation of resting membrane potential GO:0060075 3 0.041
intrinsic apoptotic signaling pathway GO:0097193 132 0.041
positive regulation of necrotic cell death GO:0010940 1 0.040
response to oxygen levels GO:0070482 62 0.040
monocarboxylic acid metabolic process GO:0032787 191 0.039
regulation of kinase activity GO:0043549 249 0.039
cation transport GO:0006812 399 0.039
cellular homeostasis GO:0019725 240 0.039
peptidyl asparagine modification GO:0018196 1 0.038
response to organonitrogen compound GO:0010243 246 0.037
leukocyte proliferation GO:0070661 172 0.036
epithelial cell proliferation GO:0050673 174 0.035
metal ion homeostasis GO:0055065 189 0.035
oxidation reduction process GO:0055114 342 0.035
protein localization to organelle GO:0033365 185 0.034
vacuole organization GO:0007033 38 0.034
digestive system development GO:0055123 200 0.034
response to hypoxia GO:0001666 58 0.034
protein modification by small protein conjugation GO:0032446 187 0.034
ubiquitin dependent protein catabolic process GO:0006511 129 0.034
maintenance of location GO:0051235 89 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.033
leukocyte differentiation GO:0002521 342 0.032
response to decreased oxygen levels GO:0036293 59 0.031
positive regulation of apoptotic process GO:0043065 217 0.031
positive regulation of protein phosphorylation GO:0001934 242 0.031
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.030
negative regulation of cellular protein metabolic process GO:0032269 247 0.030
Rat
peptidyl proline modification GO:0018208 6 0.030
peptide metabolic process GO:0006518 46 0.030
midgut development GO:0007494 4 0.030
cellular ketone metabolic process GO:0042180 84 0.029
ion transmembrane transport GO:0034220 361 0.029
inorganic ion transmembrane transport GO:0098660 234 0.029
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.029
protein modification by small protein conjugation or removal GO:0070647 207 0.028
cation transmembrane transport GO:0098655 266 0.028
kidney development GO:0001822 213 0.028
cell growth GO:0016049 130 0.027
positive regulation of protein modification process GO:0031401 299 0.027
mrna metabolic process GO:0016071 84 0.026
gland development GO:0048732 330 0.026
organonitrogen compound biosynthetic process GO:1901566 192 0.026
cellular chemical homeostasis GO:0055082 215 0.026
nitrogen compound transport GO:0071705 271 0.026
renal system development GO:0072001 225 0.026
cellular ion homeostasis GO:0006873 165 0.026
epithelial cell development GO:0002064 159 0.025
regulation of multi organism process GO:0043900 111 0.025
muscle cell differentiation GO:0042692 261 0.025
Rat
fertilization GO:0009566 127 0.025
choline transport GO:0015871 3 0.025
skeletal system development GO:0001501 356 0.025
protein ubiquitination GO:0016567 171 0.025
copper ion transport GO:0006825 10 0.025
urogenital system development GO:0001655 261 0.025
forebrain development GO:0030900 302 0.025
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.025
positive regulation of kinase activity GO:0033674 155 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.025
cellular modified amino acid metabolic process GO:0006575 63 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
regulation of vesicle mediated transport GO:0060627 139 0.024
positive regulation of transferase activity GO:0051347 167 0.024
receptor mediated endocytosis GO:0006898 51 0.024
cellular divalent inorganic cation homeostasis GO:0072503 127 0.023
skin development GO:0043588 220 0.023
cell adhesion GO:0007155 329 0.023
Human
regulation of protein kinase activity GO:0045859 232 0.022
divalent metal ion transport GO:0070838 172 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
cell type specific apoptotic process GO:0097285 268 0.021
macromolecule catabolic process GO:0009057 281 0.021
divalent inorganic cation transport GO:0072511 178 0.021
muscle system process GO:0003012 141 0.021
protein maturation GO:0051604 176 0.021
single organismal cell cell adhesion GO:0016337 131 0.020
regulation of neuron differentiation GO:0045664 281 0.020
Human
cellular response to antibiotic GO:0071236 4 0.020
regulation of secretion GO:0051046 274 0.020
mapk cascade GO:0000165 281 0.020
ear development GO:0043583 200 0.019
cellular response to oxidative stress GO:0034599 76 0.019
protein folding GO:0006457 28 0.019
Mouse Rat
negative regulation of protein tyrosine kinase activity GO:0061099 3 0.019
positive regulation of cellular amine metabolic process GO:0033240 5 0.019
blood circulation GO:0008015 195 0.019
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.019
cellular calcium ion homeostasis GO:0006874 119 0.019
immune effector process GO:0002252 321 0.019
inorganic cation transmembrane transport GO:0098662 207 0.018
compound eye development GO:0048749 1 0.018
epidermis development GO:0008544 187 0.018
nucleotide metabolic process GO:0009117 332 0.018
chromatin organization GO:0006325 206 0.018
pharynx development GO:0060465 1 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.018
extracellular structure organization GO:0043062 148 0.018
lymphocyte activation involved in immune response GO:0002285 93 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
negative regulation of protein modification process GO:0031400 163 0.018
notch receptor processing GO:0007220 4 0.018
positive regulation of hydrolase activity GO:0051345 148 0.017
nucleobase containing small molecule metabolic process GO:0055086 352 0.017
purine containing compound metabolic process GO:0072521 311 0.017
ras protein signal transduction GO:0007265 77 0.017
regulation of ion transport GO:0043269 215 0.017
developmental maturation GO:0021700 193 0.017
small gtpase mediated signal transduction GO:0007264 97 0.017
synaptic transmission GO:0007268 329 0.017
digestive tract morphogenesis GO:0048546 147 0.017
lipid localization GO:0010876 126 0.017
cellular response to interleukin 4 GO:0071353 21 0.016
cellular response to organonitrogen compound GO:0071417 145 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
substantia nigra development GO:0021762 2 0.016
divalent inorganic cation homeostasis GO:0072507 138 0.016
response to oxidative stress GO:0006979 123 0.016
regulation of transmembrane transport GO:0034762 128 0.016
peptidyl tyrosine modification GO:0018212 145 0.016
actin cytoskeleton organization GO:0030036 220 0.016
second messenger mediated signaling GO:0019932 73 0.016
nucleoside phosphate metabolic process GO:0006753 338 0.016
cellular lipid metabolic process GO:0044255 323 0.016
cellular response to lipid GO:0071396 145 0.016
mrna processing GO:0006397 63 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.016
regulation of tube size GO:0035150 57 0.016
regulation of cell motility GO:2000145 236 0.015
Human
positive regulation of protein kinase activity GO:0045860 144 0.015
response to organic cyclic compound GO:0014070 198 0.015
Rat
cell fate commitment GO:0045165 210 0.015
cellular amide metabolic process GO:0043603 58 0.015
positive regulation of growth GO:0045927 104 0.015
regulation of mapk cascade GO:0043408 248 0.015
cellular component assembly involved in morphogenesis GO:0010927 139 0.015
embryonic organ morphogenesis GO:0048562 276 0.015
cell activation involved in immune response GO:0002263 126 0.015
negative regulation of molecular function GO:0044092 258 0.015
regulation of blood pressure GO:0008217 93 0.015
regulation of anatomical structure size GO:0090066 178 0.015
regulation of phosphoprotein phosphatase activity GO:0043666 3 0.015
translation GO:0006412 93 0.015
Rat
positive regulation of apoptotic signaling pathway GO:2001235 95 0.014
calcium ion homeostasis GO:0055074 127 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
placenta development GO:0001890 140 0.014
negative regulation of nervous system development GO:0051961 156 0.014
Human
positive regulation of cell migration GO:0030335 109 0.014
Human
photoreceptor cell morphogenesis GO:0008594 3 0.014
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.014
calcium ion transport GO:0006816 159 0.014
muscle tissue development GO:0060537 308 0.014
Rat
cytokinetic process GO:0032506 2 0.014
exocytosis GO:0006887 121 0.014
response to lipopolysaccharide GO:0032496 128 0.014
regulation of hydrolase activity GO:0051336 246 0.014
stem cell differentiation GO:0048863 268 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
regulation of receptor activity GO:0010469 41 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
oocyte axis specification GO:0007309 2 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
muscle contraction GO:0006936 101 0.014
regulation of translation GO:0006417 71 0.014
Rat
t cell activation GO:0042110 289 0.014
actin filament organization GO:0007015 113 0.013
inflammatory response GO:0006954 244 0.013
dephosphorylation GO:0016311 129 0.013
regulation of ion transmembrane transport GO:0034765 119 0.013
fatty acid metabolic process GO:0006631 121 0.013
steroid metabolic process GO:0008202 119 0.013
meiotic nuclear division GO:0007126 115 0.013
response to extracellular stimulus GO:0009991 127 0.013
protein targeting GO:0006605 143 0.013
organic acid transport GO:0015849 101 0.013
carbohydrate homeostasis GO:0033500 128 0.013
negative regulation of protein metabolic process GO:0051248 282 0.013
Rat
microtubule based process GO:0007017 236 0.013
cellular response to decreased oxygen levels GO:0036294 18 0.013
immune response regulating signaling pathway GO:0002764 125 0.013
blastocyst development GO:0001824 80 0.013
regulation of phagocytosis GO:0050764 33 0.013
protein localization to membrane GO:0072657 108 0.013
neuron death GO:0070997 154 0.013
sensory organ morphogenesis GO:0090596 242 0.013
regulation of response to oxidative stress GO:1902882 19 0.013
cytokine production GO:0001816 319 0.013
positive regulation of protein transport GO:0051222 93 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
regulation of body fluid levels GO:0050878 162 0.013
regulation of cell projection organization GO:0031344 206 0.013
axonogenesis GO:0007409 274 0.013
extracellular matrix organization GO:0030198 147 0.012
defense response to other organism GO:0098542 197 0.012
cytoskeleton dependent intracellular transport GO:0030705 50 0.012
organic hydroxy compound transport GO:0015850 93 0.012
oocyte construction GO:0007308 2 0.012
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.012
protein targeting to er GO:0045047 2 0.012
negative regulation of phosphorus metabolic process GO:0010563 184 0.012
small molecule biosynthetic process GO:0044283 132 0.012
establishment of vesicle localization GO:0051650 81 0.012
microtubule based movement GO:0007018 84 0.012
regulation of neurotransmitter levels GO:0001505 87 0.012
lipoprotein metabolic process GO:0042157 43 0.012
organonitrogen compound catabolic process GO:1901565 264 0.012
purine containing compound catabolic process GO:0072523 213 0.012
immunoglobulin production GO:0002377 73 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
purine ribonucleotide metabolic process GO:0009150 290 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.012
purine nucleotide metabolic process GO:0006163 302 0.012
retrograde transport endosome to golgi GO:0042147 2 0.012
regulation of system process GO:0044057 200 0.012
cellularization GO:0007349 1 0.012
cellular metal ion homeostasis GO:0006875 151 0.012
protein n linked glycosylation via asparagine GO:0018279 1 0.012
defense response to gram positive bacterium GO:0050830 50 0.012
regulation of hormone levels GO:0010817 211 0.012
b cell activation GO:0042113 161 0.012
ameboidal type cell migration GO:0001667 128 0.012
leukocyte activation involved in immune response GO:0002366 126 0.012
response to acid chemical GO:0001101 111 0.012
autophagy GO:0006914 45 0.012
learning or memory GO:0007611 148 0.012
mesoderm development GO:0007498 100 0.011
positive regulation of cell activation GO:0050867 158 0.011
response to growth factor GO:0070848 198 0.011
heart morphogenesis GO:0003007 178 0.011
nucleotide sugar metabolic process GO:0009225 4 0.011
tube formation GO:0035148 140 0.011
regulation of protein serine threonine kinase activity GO:0071900 157 0.011
neural tube development GO:0021915 160 0.011
cellular response to external stimulus GO:0071496 88 0.011
neuron apoptotic process GO:0051402 142 0.011
embryonic limb morphogenesis GO:0030326 126 0.011
cellular response to extracellular stimulus GO:0031668 81 0.011
regulation of cellular catabolic process GO:0031329 242 0.011
regulation of cellular component biogenesis GO:0044087 181 0.011
negative regulation of cellular component organization GO:0051129 194 0.011
multi multicellular organism process GO:0044706 109 0.011
production of molecular mediator of immune response GO:0002440 103 0.011
ossification GO:0001503 216 0.011
peptidyl tyrosine phosphorylation GO:0018108 143 0.011
carboxylic acid transport GO:0046942 100 0.011
lymphocyte differentiation GO:0030098 242 0.011
nucleoside triphosphate catabolic process GO:0009143 205 0.011
endodermal digestive tract morphogenesis GO:0061031 4 0.011
cellular response to lipopolysaccharide GO:0071222 77 0.011
regulation of cytokine production GO:0001817 266 0.011
regulation of ossification GO:0030278 112 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
cellular response to biotic stimulus GO:0071216 92 0.011
lymphocyte proliferation GO:0046651 164 0.011
negative regulation of cell projection organization GO:0031345 56 0.011
membrane organization GO:0061024 245 0.011
regulation of endocytosis GO:0030100 69 0.011
organic acid biosynthetic process GO:0016053 86 0.011
establishment of synaptic vesicle localization GO:0097480 57 0.011
heterochromatin organization GO:0070828 4 0.011
negative regulation of response to endoplasmic reticulum stress GO:1903573 8 0.011
positive regulation of cell motility GO:2000147 116 0.011
Human
ribonucleotide metabolic process GO:0009259 291 0.011
regulation of neuron projection development GO:0010975 169 0.011
negative regulation of intracellular signal transduction GO:1902532 167 0.011
t cell proliferation GO:0042098 120 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
mesenchymal cell differentiation GO:0048762 107 0.011
male sex differentiation GO:0046661 109 0.011
adult behavior GO:0030534 135 0.011
mesenchyme development GO:0060485 152 0.011
protein secretion GO:0009306 111 0.011
cell maturation GO:0048469 127 0.010
gonad development GO:0008406 141 0.010
cellular protein complex assembly GO:0043623 116 0.010
regulation of cellular response to oxidative stress GO:1900407 19 0.010
negative regulation of cellular amine metabolic process GO:0033239 1 0.010
ribonucleoside metabolic process GO:0009119 245 0.010
myotube cell development GO:0014904 60 0.010
response to peptide hormone GO:0043434 127 0.010
myeloid leukocyte differentiation GO:0002573 119 0.010
fat cell differentiation GO:0045444 160 0.010
regulation of binding GO:0051098 111 0.010
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.010
skeletal system morphogenesis GO:0048705 203 0.010
negative regulation of neuron projection development GO:0010977 50 0.010
negative regulation of epidermal growth factor activated receptor activity GO:0007175 3 0.010

Calr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.051
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.040
central nervous system disease DOID:331 0 0.040
connective tissue disease DOID:65 0 0.039
musculoskeletal system disease DOID:17 0 0.039
cardiovascular system disease DOID:1287 0 0.037
muscle tissue disease DOID:66 0 0.037
cardiomyopathy DOID:0050700 0 0.037
myopathy DOID:423 0 0.037
muscular disease DOID:0080000 0 0.037
heart disease DOID:114 0 0.037
integumentary system disease DOID:16 0 0.035
neurodegenerative disease DOID:1289 0 0.031
tauopathy DOID:680 0 0.031
inherited metabolic disorder DOID:655 0 0.027
disease of mental health DOID:150 0 0.025
dementia DOID:1307 0 0.025
alzheimer s disease DOID:10652 0 0.025
cognitive disorder DOID:1561 0 0.025
bone disease DOID:0080001 0 0.023
acquired metabolic disease DOID:0060158 0 0.022
intrinsic cardiomyopathy DOID:0060036 0 0.020
neuropathy DOID:870 0 0.015
skin disease DOID:37 0 0.015
bone development disease DOID:0080006 0 0.013
dilated cardiomyopathy DOID:12930 0 0.013
sensory system disease DOID:0050155 0 0.012
immune system disease DOID:2914 0 0.010