Mus musculus

186 known processes

Cdkn1b

cyclin-dependent kinase inhibitor 1B

(Aliases: AI843786,p27,Kip1,AA408329,p27Kip1)

Cdkn1b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of somitogenesis GO:0014807 6 1.000
regulation of cellular ketone metabolic process GO:0010565 66 1.000
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.999
cellular response to dna damage stimulus GO:0006974 207 0.999
Mouse
t cell activation GO:0042110 289 0.999
mitotic cell cycle GO:0000278 195 0.999
regulation of insulin receptor signaling pathway GO:0046626 21 0.997
regionalization GO:0003002 337 0.997
response to ionizing radiation GO:0010212 42 0.995
Mouse
regulation of kinase activity GO:0043549 249 0.994
negative regulation of cell proliferation GO:0008285 296 0.993
negative regulation of protein phosphorylation GO:0001933 126 0.992
regulation of fat cell differentiation GO:0045598 81 0.991
signal transduction by p53 class mediator GO:0072331 51 0.990
Mouse
cellular ketone metabolic process GO:0042180 84 0.990
negative regulation of fat cell differentiation GO:0045599 36 0.990
lymphocyte differentiation GO:0030098 242 0.989
regulation of mitotic cell cycle GO:0007346 126 0.989
Human Mouse
regulation of transferase activity GO:0051338 263 0.988
liver development GO:0001889 66 0.987
mitotic g1 dna damage checkpoint GO:0031571 4 0.986
regulation of feeding behavior GO:0060259 3 0.985
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.985
cellular response to peptide GO:1901653 92 0.985
negative regulation of kinase activity GO:0033673 81 0.985
negative regulation of cell cycle phase transition GO:1901988 48 0.984
negative regulation of growth GO:0045926 99 0.983
Human
negative regulation of transferase activity GO:0051348 85 0.983
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.982
Mouse
regulation of hydrolase activity GO:0051336 246 0.982
Human
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.981
gland development GO:0048732 330 0.980
regulation of bmp signaling pathway GO:0030510 60 0.979
response to testosterone GO:0033574 3 0.978
negative regulation of leukocyte differentiation GO:1902106 51 0.978
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.977
negative regulation of cell cycle GO:0045786 123 0.977
response to x ray GO:0010165 11 0.976
g1 s transition of mitotic cell cycle GO:0000082 57 0.976
regulation of cell cycle GO:0051726 281 0.976
cyclic purine nucleotide metabolic process GO:0052652 43 0.975
regulation of cohesin localization to chromatin GO:0071922 1 0.974
regulation of protein import into nucleus translocation GO:0033158 2 0.972
Mouse
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.970
intrinsic apoptotic signaling pathway GO:0097193 132 0.970
Mouse
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.968
cohesin localization to chromatin GO:0071921 1 0.966
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.963
positive regulation of peptide hormone secretion GO:0090277 31 0.963
negative regulation of phosphorylation GO:0042326 166 0.961
fat cell differentiation GO:0045444 160 0.961
apoptotic signaling pathway GO:0097190 306 0.958
Mouse
response to nutrient levels GO:0031667 109 0.957
dna damage checkpoint GO:0000077 26 0.953
wnt signaling pathway GO:0016055 188 0.951
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.949
monosaccharide metabolic process GO:0005996 106 0.947
regulation of cellular amino acid metabolic process GO:0006521 5 0.947
cellular amino acid metabolic process GO:0006520 103 0.944
regulation of cell cycle process GO:0010564 160 0.942
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.941
cellular response to hormone stimulus GO:0032870 150 0.938
regulation of cell cycle phase transition GO:1901987 77 0.935
cellular response to peptide hormone stimulus GO:0071375 92 0.934
erythrocyte differentiation GO:0030218 88 0.933
response to peptide GO:1901652 136 0.931
regulation of nucleocytoplasmic transport GO:0046822 73 0.930
Mouse
regulation of triglyceride metabolic process GO:0090207 17 0.930
somitogenesis GO:0001756 69 0.929
macroautophagy GO:0016236 21 0.926
mitotic cell cycle process GO:1903047 159 0.922
insulin secretion GO:0030073 89 0.922
jak stat cascade GO:0007259 42 0.921
positive regulation of cell cycle GO:0045787 92 0.919
intra s dna damage checkpoint GO:0031573 4 0.918
microtubule based process GO:0007017 236 0.917
multicellular organism growth GO:0035264 161 0.917
regulation of protein kinase activity GO:0045859 232 0.914
lactation GO:0007595 25 0.914
leukocyte proliferation GO:0070661 172 0.912
Mouse
male gamete generation GO:0048232 285 0.909
negative regulation of glial cell proliferation GO:0060253 4 0.906
response to organonitrogen compound GO:0010243 246 0.904
negative regulation of oligodendrocyte differentiation GO:0048715 11 0.904
regulation of mitotic cell cycle phase transition GO:1901990 73 0.903
positive regulation of transferase activity GO:0051347 167 0.900
germ cell development GO:0007281 185 0.899
neuron death GO:0070997 154 0.897
negative regulation of mitotic cell cycle GO:0045930 58 0.889
Human
positive regulation of kinase activity GO:0033674 155 0.889
enucleate erythrocyte differentiation GO:0043353 8 0.889
cellular response to cytokine stimulus GO:0071345 189 0.888
carbohydrate homeostasis GO:0033500 128 0.884
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.883
regulation of cellular amine metabolic process GO:0033238 20 0.881
cellular glucan metabolic process GO:0006073 32 0.876
insulin receptor signaling pathway GO:0008286 49 0.876
somite development GO:0061053 81 0.873
cell cycle arrest GO:0007050 37 0.870
negative regulation of auditory receptor cell differentiation GO:0045608 2 0.867
negative regulation of cell cycle arrest GO:0071157 1 0.865
negative regulation of epithelial cell proliferation GO:0050680 64 0.864
canonical wnt signaling pathway GO:0060070 130 0.863
negative regulation of t cell differentiation GO:0045581 23 0.861
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.861
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.857
Mouse
cyclic nucleotide biosynthetic process GO:0009190 44 0.856
mammary gland epithelium development GO:0061180 65 0.854
negative regulation of epithelial cell proliferation involved in prostate gland development GO:0060770 7 0.853
positive regulation of cell development GO:0010720 237 0.851
creatine metabolic process GO:0006600 4 0.849
positive regulation of camp metabolic process GO:0030816 19 0.848
cell growth GO:0016049 130 0.848
Human
mitotic cell cycle checkpoint GO:0007093 31 0.847
positive regulation of bmp signaling pathway GO:0030513 23 0.845
positive regulation of apoptotic signaling pathway GO:2001235 95 0.844
acylglycerol metabolic process GO:0006639 55 0.839
response to extracellular stimulus GO:0009991 127 0.838
mitotic cell cycle arrest GO:0071850 4 0.837
Human Mouse
positive regulation of epithelial cell proliferation GO:0050679 68 0.835
lymphocyte proliferation GO:0046651 164 0.833
Mouse
regulation of lymphocyte activation GO:0051249 240 0.833
Mouse
t cell differentiation GO:0030217 174 0.832
cellular senescence GO:0090398 11 0.831
regulation of cellular catabolic process GO:0031329 242 0.830
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.830
spermatogenesis GO:0007283 284 0.829
hepaticobiliary system development GO:0061008 67 0.824
cellular amine metabolic process GO:0044106 44 0.821
epithelial tube morphogenesis GO:0060562 303 0.819
cell cycle g1 s phase transition GO:0044843 57 0.818
regulation of cellular response to stress GO:0080135 159 0.816
response to insulin GO:0032868 100 0.816
b cell proliferation GO:0042100 53 0.813
Mouse
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.812
regulation of intracellular transport GO:0032386 159 0.809
Mouse
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.802
regulation of lymphocyte proliferation GO:0050670 117 0.795
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 82 0.795
negative regulation of phosphorus metabolic process GO:0010563 184 0.794
peripheral nervous system neuron axonogenesis GO:0048936 3 0.793
carbohydrate derivative biosynthetic process GO:1901137 183 0.792
stem cell development GO:0048864 219 0.792
hormone mediated signaling pathway GO:0009755 23 0.792
positive regulation of protein modification process GO:0031401 299 0.787
cell division GO:0051301 120 0.782
radial glial cell differentiation GO:0060019 6 0.782
activation of janus kinase activity GO:0042976 2 0.781
androgen receptor signaling pathway GO:0030521 8 0.780
stem cell differentiation GO:0048863 268 0.780
stem cell maintenance GO:0019827 130 0.779
regulation of neural precursor cell proliferation GO:2000177 70 0.777
forebrain radial glial cell differentiation GO:0021861 4 0.771
negative regulation of pancreatic a cell differentiation GO:2000227 1 0.769
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.768
positive regulation of mitotic cell cycle GO:0045931 41 0.765
regulation of apoptotic signaling pathway GO:2001233 197 0.765
cell cycle checkpoint GO:0000075 47 0.764
cellular response to growth factor stimulus GO:0071363 197 0.763
embryonic organ morphogenesis GO:0048562 276 0.756
regulation of lipid metabolic process GO:0019216 118 0.755
sensory organ morphogenesis GO:0090596 242 0.752
dna integrity checkpoint GO:0031570 28 0.750
glucose homeostasis GO:0042593 128 0.748
t cell proliferation GO:0042098 120 0.747
generation of precursor metabolites and energy GO:0006091 103 0.744
protein localization to organelle GO:0033365 185 0.743
Mouse
rhythmic process GO:0048511 174 0.739
positive regulation of hormone secretion GO:0046887 38 0.737
myeloid cell differentiation GO:0030099 233 0.736
regulation of jak stat cascade GO:0046425 34 0.735
negative regulation of lymphocyte differentiation GO:0045620 32 0.735
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.734
regulation of androgen receptor signaling pathway GO:0060765 3 0.734
midbrain hindbrain boundary morphogenesis GO:0021555 4 0.732
positive regulation of histone h3 k9 methylation GO:0051574 4 0.727
positive regulation of cellular amine metabolic process GO:0033240 5 0.727
specification of loop of henle identity GO:0072086 4 0.726
prostate gland morphogenetic growth GO:0060737 4 0.722
regulation of glucose metabolic process GO:0010906 60 0.722
hexose biosynthetic process GO:0019319 39 0.718
positive regulation of protein kinase activity GO:0045860 144 0.716
positive regulation of protein phosphorylation GO:0001934 242 0.715
positive regulation of programmed cell death GO:0043068 218 0.713
Human Mouse
positive regulation of b cell proliferation GO:0030890 24 0.712
Mouse
negative regulation of cellular senescence GO:2000773 3 0.711
cellular polysaccharide metabolic process GO:0044264 38 0.710
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.709
regulation of stomach neuroendocrine cell differentiation GO:0061105 1 0.708
triglyceride metabolic process GO:0006641 51 0.707
regulation of notch signaling pathway GO:0008593 35 0.704
cellular carbohydrate metabolic process GO:0044262 119 0.703
mammary gland lobule development GO:0061377 22 0.703
regulation of wnt signaling pathway GO:0030111 123 0.699
response to peptide hormone GO:0043434 127 0.698
maintenance of epithelial cell apical basal polarity GO:0045199 2 0.694
regulation of lipid kinase activity GO:0043550 14 0.693
epithelial cell proliferation GO:0050673 174 0.687
cellular response to nutrient levels GO:0031669 64 0.686
carbohydrate metabolic process GO:0005975 230 0.683
muscle cell differentiation GO:0042692 261 0.681
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.680
prostate gland development GO:0030850 48 0.679
somite specification GO:0001757 4 0.679
pole plasm assembly GO:0007315 2 0.676
creatinine metabolic process GO:0046449 3 0.674
regulation of camp metabolic process GO:0030814 30 0.673
polysaccharide metabolic process GO:0005976 39 0.672
b cell activation GO:0042113 161 0.672
Mouse
microtubule cytoskeleton organization GO:0000226 157 0.669
development of primary female sexual characteristics GO:0046545 73 0.667
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.665
positive regulation of cell death GO:0010942 224 0.664
Human Mouse
notch signaling pathway GO:0007219 71 0.664
regulation of fatty acid metabolic process GO:0019217 28 0.662
positive regulation of carbohydrate metabolic process GO:0045913 30 0.661
camp biosynthetic process GO:0006171 31 0.661
regulation of response to wounding GO:1903034 189 0.661
negative regulation of organ growth GO:0046621 17 0.661
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.659
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.656
male gonad development GO:0008584 88 0.656
segmentation GO:0035282 93 0.653
cellular response to organonitrogen compound GO:0071417 145 0.652
negative regulation of endothelial cell migration GO:0010596 4 0.650
signal transduction in absence of ligand GO:0038034 55 0.648
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.645
regulation of protein serine threonine kinase activity GO:0071900 157 0.645
organophosphate biosynthetic process GO:0090407 122 0.644
negative regulation of glial cell differentiation GO:0045686 21 0.644
glycerolipid metabolic process GO:0046486 122 0.643
positive regulation of apoptotic process GO:0043065 217 0.642
Human
positive regulation of endothelial cell proliferation GO:0001938 17 0.641
fibroblast proliferation GO:0048144 35 0.639
regulation of gliogenesis GO:0014013 50 0.636
small gtpase mediated signal transduction GO:0007264 97 0.635
negative regulation of cell growth GO:0030308 44 0.635
Human
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.631
signal transduction involved in dna damage checkpoint GO:0072422 3 0.629
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.628
negative regulation of cellular amine metabolic process GO:0033239 1 0.626
regulation of fatty acid oxidation GO:0046320 10 0.623
glomerulus development GO:0032835 40 0.617
gluconeogenesis GO:0006094 39 0.616
dna metabolic process GO:0006259 303 0.613
Mouse
amine metabolic process GO:0009308 45 0.612
regulation of nucleotide biosynthetic process GO:0030808 34 0.612
nuclear transport GO:0051169 139 0.611
Mouse
cellular macromolecule catabolic process GO:0044265 206 0.606
response to vitamin d GO:0033280 3 0.604
negative regulation of phosphate metabolic process GO:0045936 184 0.603
regulation of transcription by galactose GO:0000409 1 0.601
neuroblast fate determination GO:0007400 1 0.599
regulation of adenylate cyclase activity GO:0045761 10 0.599
stat protein import into nucleus GO:0007262 6 0.596
negative regulation of molecular function GO:0044092 258 0.594
dna biosynthetic process GO:0071897 22 0.592
Mouse
positive regulation of fibroblast proliferation GO:0048146 20 0.591
response to ketone GO:1901654 15 0.587
negative regulation of protein processing GO:0010955 79 0.587
formation of radial glial scaffolds GO:0021943 4 0.587
lipid biosynthetic process GO:0008610 179 0.586
negative regulation of fatty acid metabolic process GO:0045922 10 0.585
neuron apoptotic process GO:0051402 142 0.581
regulation of peptide secretion GO:0002791 77 0.577
central nervous system myelination GO:0022010 12 0.575
regulation of cell growth GO:0001558 91 0.565
Human
regulation of carbohydrate metabolic process GO:0006109 75 0.562
cell adhesion GO:0007155 329 0.561
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.559
regulation of gluconeogenesis GO:0006111 30 0.559
negative regulation of inner ear receptor cell differentiation GO:2000981 3 0.557
prolactin signaling pathway GO:0038161 5 0.555
response to light stimulus GO:0009416 135 0.548
Mouse
sprouting angiogenesis GO:0002040 26 0.548
stem cell proliferation GO:0072089 117 0.546
antral ovarian follicle growth GO:0001547 5 0.546
circadian regulation of gene expression GO:0032922 48 0.543
negative regulation of cell motility GO:2000146 61 0.538
response to alcohol GO:0097305 48 0.534
stomach neuroendocrine cell differentiation GO:0061102 2 0.533
regulation of epithelial cell proliferation GO:0050678 141 0.532
negative regulation of astrocyte differentiation GO:0048712 10 0.529
peptidyl tyrosine phosphorylation GO:0018108 143 0.526
regulation of cell cycle g1 s phase transition GO:1902806 35 0.524
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.522
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 24 0.518
Mouse
microtubule polymerization or depolymerization GO:0031109 26 0.517
development of primary sexual characteristics GO:0045137 143 0.516
nuclear import GO:0051170 95 0.512
Mouse
regulation of oligodendrocyte differentiation GO:0048713 23 0.510
negative regulation of protein metabolic process GO:0051248 282 0.509
negative regulation of systemic arterial blood pressure GO:0003085 15 0.509
regulation of macroautophagy GO:0016241 12 0.507
negative regulation of gliogenesis GO:0014014 23 0.504
organ regeneration GO:0031100 2 0.503
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.503
negative regulation of stomach neuroendocrine cell differentiation GO:0061106 1 0.503
monosaccharide biosynthetic process GO:0046364 44 0.502
regulation of gluconeogenesis by regulation of transcription from rna polymerase ii promoter GO:0035947 7 0.502
ossification GO:0001503 216 0.501
innate immune response GO:0045087 157 0.500
response to corticosteroid GO:0031960 20 0.498
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.498
positive regulation of mitotic cell cycle embryonic GO:0045977 2 0.497
succinate metabolic process GO:0006105 4 0.494
extrinsic apoptotic signaling pathway GO:0097191 126 0.493
regulation of cell division GO:0051302 76 0.492
mammary gland alveolus development GO:0060749 22 0.492
regulation of cell migration GO:0030334 219 0.490
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.490
regulation of pro b cell differentiation GO:2000973 5 0.488
axonogenesis GO:0007409 274 0.485
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.484
regulation of secretion by cell GO:1903530 249 0.484
leukocyte differentiation GO:0002521 342 0.483
enteroendocrine cell differentiation GO:0035883 16 0.483
negative regulation of response to dna damage stimulus GO:2001021 10 0.482
cellular homeostasis GO:0019725 240 0.480
regulation of response to dna damage stimulus GO:2001020 34 0.480
negative regulation of cell activation GO:0050866 111 0.477
oligodendrocyte development GO:0014003 20 0.475
negative regulation of protein modification process GO:0031400 163 0.474
regulation of b cell proliferation GO:0030888 39 0.468
Mouse
glial cell apoptotic process GO:0034349 3 0.467
cellular response to extracellular stimulus GO:0031668 81 0.462
nuclear division GO:0000280 158 0.461
development of primary male sexual characteristics GO:0046546 88 0.460
endothelial tube morphogenesis GO:0061154 2 0.459
negative regulation of mechanoreceptor differentiation GO:0045632 3 0.458
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.458
response to oxygen levels GO:0070482 62 0.456
hexose metabolic process GO:0019318 98 0.456
protein maturation GO:0051604 176 0.456
Human
positive regulation of macrophage differentiation GO:0045651 5 0.456
positive regulation of lipid catabolic process GO:0050996 6 0.455
regulation of protein processing GO:0070613 96 0.454
epithelial cell differentiation involved in prostate gland development GO:0060742 13 0.453
regulation of neuron apoptotic process GO:0043523 122 0.444
regulation of cysteine type endopeptidase activity GO:2000116 65 0.442
Human
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.441
regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902229 14 0.440
camp metabolic process GO:0046058 40 0.437
segment specification GO:0007379 15 0.437
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.437
cell fate determination GO:0001709 32 0.435
positive regulation of dephosphorylation GO:0035306 6 0.431
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.430
maintenance of location GO:0051235 89 0.429
protein autophosphorylation GO:0046777 61 0.429
positive regulation of gluconeogenesis GO:0045722 11 0.427
glycogen metabolic process GO:0005977 32 0.427
homeostasis of number of cells GO:0048872 210 0.426
organic cyclic compound catabolic process GO:1901361 295 0.424
nucleotide biosynthetic process GO:0009165 78 0.422
heterocycle catabolic process GO:0046700 280 0.422
response to radiation GO:0009314 165 0.421
Mouse
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.421
regulation of transcription involved in cell fate commitment GO:0060850 15 0.419
regulation of leukocyte differentiation GO:1902105 159 0.417
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.415
glandular epithelial cell differentiation GO:0002067 38 0.415
reactive oxygen species metabolic process GO:0072593 84 0.414
Mouse
regulation of t cell differentiation GO:0045580 83 0.413
skeletal muscle cell differentiation GO:0035914 66 0.413
positive regulation of neuron apoptotic process GO:0043525 25 0.412
type i pneumocyte differentiation GO:0060509 7 0.408
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.404
blood vessel morphogenesis GO:0048514 285 0.403
peptide transport GO:0015833 133 0.401
bmp signaling pathway GO:0030509 93 0.400
gliogenesis GO:0042063 141 0.400
protein localization to nucleus GO:0034504 121 0.395
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 104 0.394
tyrosine phosphorylation of stat protein GO:0007260 23 0.393
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.390
mitotic spindle organization GO:0007052 10 0.389
prostate gland growth GO:0060736 13 0.389
regulation of histone methylation GO:0031060 30 0.388
positive regulation of stress fiber assembly GO:0051496 9 0.388
inner ear receptor cell differentiation GO:0060113 61 0.388
purine nucleotide biosynthetic process GO:0006164 65 0.387
actin cytoskeleton reorganization GO:0031532 21 0.386
morphogenesis of a branching structure GO:0001763 203 0.386
lipid localization GO:0010876 126 0.385
cellular response to growth hormone stimulus GO:0071378 7 0.383
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.383
response to uv GO:0009411 44 0.383
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.382
negative regulation of immune system process GO:0002683 209 0.381
positive regulation of organelle organization GO:0010638 128 0.375
inositol lipid mediated signaling GO:0048017 41 0.374
energy reserve metabolic process GO:0006112 39 0.374
regulation of auditory receptor cell differentiation GO:0045607 4 0.371
immature b cell differentiation GO:0002327 10 0.370
positive regulation of osteoblast differentiation GO:0045669 34 0.369
forebrain development GO:0030900 302 0.369
somatic stem cell maintenance GO:0035019 47 0.369
purine nucleoside metabolic process GO:0042278 241 0.368
positive regulation of histone methylation GO:0031062 16 0.367
negative regulation of fibroblast migration GO:0010764 2 0.366
learning or memory GO:0007611 148 0.365
circadian rhythm GO:0007623 114 0.365
response to corticosterone GO:0051412 1 0.364
apoptotic process involved in mammary gland involution GO:0060057 4 0.364
regulation of canonical wnt signaling pathway GO:0060828 82 0.364
positive regulation of macrophage apoptotic process GO:2000111 3 0.361
glucose metabolic process GO:0006006 92 0.361
locomotor rhythm GO:0045475 8 0.361
hormone secretion GO:0046879 128 0.360
regulation of cell adhesion GO:0030155 154 0.358
somite rostral caudal axis specification GO:0032525 13 0.356
regulation of t cell activation GO:0050863 170 0.356
activation of jak2 kinase activity GO:0042977 2 0.355
hindbrain radial glia guided cell migration GO:0021932 12 0.353
valine metabolic process GO:0006573 4 0.349
chromatin silencing GO:0006342 15 0.349
positive regulation of glial cell proliferation GO:0060252 4 0.347
ear development GO:0043583 200 0.346
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.345
activation of cysteine type endopeptidase activity GO:0097202 27 0.345
Human
positive regulation of mammary gland epithelial cell proliferation GO:0033601 5 0.344
positive regulation of lymphocyte activation GO:0051251 140 0.344
Mouse
neural precursor cell proliferation GO:0061351 121 0.343
regulation of hormone levels GO:0010817 211 0.343
angiogenesis GO:0001525 201 0.341
taurine metabolic process GO:0019530 4 0.341
establishment of protein localization to organelle GO:0072594 118 0.339
Mouse
actin filament bundle assembly GO:0051017 40 0.339
response to organic cyclic compound GO:0014070 198 0.338
positive regulation of myeloid cell apoptotic process GO:0033034 4 0.336
attachment of spindle microtubules to kinetochore GO:0008608 4 0.334
positive regulation of proteolysis GO:0045862 85 0.333
Human
leydig cell differentiation GO:0033327 10 0.333
regulation of leukocyte proliferation GO:0070663 121 0.332
Mouse
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.332
organ growth GO:0035265 117 0.332
female gamete generation GO:0007292 74 0.331
response to steroid hormone GO:0048545 56 0.328
adaptive immune response GO:0002250 155 0.326
posttranscriptional regulation of gene expression GO:0010608 155 0.325
steroid hormone mediated signaling pathway GO:0043401 6 0.324
regulation of microtubule polymerization GO:0031113 7 0.323
smoothened signaling pathway GO:0007224 105 0.322
regulation of cellular response to insulin stimulus GO:1900076 30 0.321
odontogenesis GO:0042476 78 0.320
negative regulation of hydrolase activity GO:0051346 71 0.318
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.317
negative regulation of mammary gland epithelial cell proliferation GO:0033600 3 0.315
response to iron ion GO:0010039 4 0.315
blastocyst growth GO:0001832 23 0.313
mitotic sister chromatid cohesion GO:0007064 1 0.313
cellular response to oxidative stress GO:0034599 76 0.310
negative regulation of oxidative stress induced cell death GO:1903202 9 0.310
maintenance of apical basal cell polarity GO:0035090 3 0.309
activation of adenylate cyclase activity GO:0007190 4 0.309
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.307
mapk cascade GO:0000165 281 0.307
dna repair GO:0006281 107 0.306
regulation of neuron differentiation GO:0045664 281 0.305
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 6 0.304
nucleoside triphosphate catabolic process GO:0009143 205 0.304
mitotic g2 dna damage checkpoint GO:0007095 8 0.304
defense response to bacterium GO:0042742 119 0.303
cell type specific apoptotic process GO:0097285 268 0.302
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.302
purine ribonucleotide biosynthetic process GO:0009152 59 0.298
oligodendrocyte differentiation GO:0048709 53 0.298
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.296

Cdkn1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system cancer DOID:0060083 0 0.994
cancer DOID:162 0 0.994
disease of cellular proliferation DOID:14566 0 0.994
organ system cancer DOID:0050686 0 0.994
hematologic cancer DOID:2531 0 0.982
bone marrow cancer DOID:4960 0 0.903
disease of metabolism DOID:0014667 0 0.878
urinary system cancer DOID:3996 0 0.550
disease of anatomical entity DOID:7 0 0.505
endocrine system disease DOID:28 0 0.505
colon carcinoma DOID:1520 0 0.482
large intestine cancer DOID:5672 0 0.482
colon cancer DOID:219 0 0.482
gastrointestinal system cancer DOID:3119 0 0.482
intestinal cancer DOID:10155 0 0.482
colorectal cancer DOID:9256 0 0.482
diabetes mellitus DOID:9351 0 0.404
type 2 diabetes mellitus DOID:9352 0 0.404
carbohydrate metabolism disease DOID:0050013 0 0.404
glucose metabolism disease DOID:4194 0 0.404
acquired metabolic disease DOID:0060158 0 0.404
immune system disease DOID:2914 0 0.385
bone marrow disease DOID:4961 0 0.385
hematopoietic system disease DOID:74 0 0.385
respiratory system cancer DOID:0050615 0 0.318
lung cancer DOID:1324 0 0.318