Mus musculus

151 known processes

Chek1

checkpoint kinase 1 homolog (S. pombe)

(Aliases: rad27,Chk1,C85740)

Chek1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.960
microtubule cytoskeleton organization GO:0000226 157 0.783
Human
cellular response to dna damage stimulus GO:0006974 207 0.776
meiotic cell cycle GO:0051321 122 0.749
dna repair GO:0006281 107 0.716
nuclear division GO:0000280 158 0.681
Human
meiosis i GO:0007127 60 0.603
double strand break repair GO:0006302 48 0.599
Human
organelle fission GO:0048285 170 0.591
Human
mitotic cell cycle process GO:1903047 159 0.563
cellular macromolecule catabolic process GO:0044265 206 0.544
modification dependent protein catabolic process GO:0019941 133 0.496
cellular protein catabolic process GO:0044257 155 0.466
meiotic nuclear division GO:0007126 115 0.462
meiotic cell cycle process GO:1903046 77 0.444
regulation of cell cycle GO:0051726 281 0.426
Human Zebrafish Rat
negative regulation of cell cycle GO:0045786 123 0.418
Human Zebrafish Rat
regulation of cell division GO:0051302 76 0.391
Human
gonad development GO:0008406 141 0.380
chromosome segregation GO:0007059 48 0.372
female meiosis chromosome segregation GO:0016321 1 0.344
mitotic sister chromatid cohesion GO:0007064 1 0.313
dna recombination GO:0006310 92 0.293
Human
cell cycle checkpoint GO:0000075 47 0.283
protein catabolic process GO:0030163 221 0.272
development of primary sexual characteristics GO:0045137 143 0.265
dna endoreduplication GO:0042023 4 0.257
regulation of mitotic cell cycle phase transition GO:1901990 73 0.257
Zebrafish Rat
macromolecule catabolic process GO:0009057 281 0.251
mitotic sister chromatid segregation GO:0000070 14 0.247
regulation of mitotic cell cycle GO:0007346 126 0.239
Human Zebrafish Rat
mitotic cell cycle GO:0000278 195 0.230
regulation of cell cycle phase transition GO:1901987 77 0.227
Zebrafish Rat
regulation of cell cycle process GO:0010564 160 0.227
Human Zebrafish Rat
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.220
ubiquitin dependent protein catabolic process GO:0006511 129 0.213
translesion synthesis GO:0019985 1 0.212
regulation of mitosis GO:0007088 29 0.212
Human
negative regulation of cell cycle phase transition GO:1901988 48 0.210
Zebrafish Rat
regulation of chromosome organization GO:0033044 83 0.199
heterochromatin organization GO:0070828 4 0.195
microtubule based process GO:0007017 236 0.186
Human
dna replication GO:0006260 52 0.177
regulation of cellular catabolic process GO:0031329 242 0.171
protein ubiquitination GO:0016567 171 0.168
female meiotic division GO:0007143 21 0.164
positive regulation of cell cycle GO:0045787 92 0.159
recombinational repair GO:0000725 21 0.156
Human
organelle assembly GO:0070925 177 0.155
dna dependent dna replication GO:0006261 24 0.152
purine nucleotide metabolic process GO:0006163 302 0.145
chromatin organization GO:0006325 206 0.144
negative regulation of nuclear division GO:0051784 19 0.140
Human
nucleoside triphosphate metabolic process GO:0009141 230 0.136
negative regulation of mitotic cell cycle GO:0045930 58 0.136
Human Zebrafish Rat
mitotic nuclear division GO:0007067 48 0.134
Human
genitalia development GO:0048806 37 0.133
male gamete generation GO:0048232 285 0.131
response to light stimulus GO:0009416 135 0.129
apoptotic signaling pathway GO:0097190 306 0.123
Zebrafish
maintenance of location GO:0051235 89 0.113
intrinsic apoptotic signaling pathway GO:0097193 132 0.112
Zebrafish
response to radiation GO:0009314 165 0.111
ribonucleoside catabolic process GO:0042454 206 0.108
establishment of organelle localization GO:0051656 122 0.104
male meiosis GO:0007140 37 0.102
organonitrogen compound catabolic process GO:1901565 264 0.100
regulation of organelle organization GO:0033043 289 0.097
purine ribonucleotide metabolic process GO:0009150 290 0.091
modification dependent macromolecule catabolic process GO:0043632 133 0.090
spermatogenesis GO:0007283 284 0.088
purine nucleoside monophosphate catabolic process GO:0009128 58 0.088
sister chromatid segregation GO:0000819 20 0.083
double strand break repair via homologous recombination GO:0000724 21 0.083
Human
purine nucleoside triphosphate metabolic process GO:0009144 226 0.082
dna replication independent nucleosome assembly GO:0006336 1 0.081
nucleoside phosphate metabolic process GO:0006753 338 0.080
positive regulation of apoptotic process GO:0043065 217 0.078
ribose phosphate metabolic process GO:0019693 291 0.078
cell division GO:0051301 120 0.077
Human
protein modification by small protein conjugation or removal GO:0070647 207 0.073
mitotic chromosome condensation GO:0007076 1 0.073
atp metabolic process GO:0046034 75 0.072
cellular response to abiotic stimulus GO:0071214 56 0.071
cellular ketone metabolic process GO:0042180 84 0.070
microtubule organizing center organization GO:0031023 28 0.070
Human
positive regulation of programmed cell death GO:0043068 218 0.069
glycosyl compound catabolic process GO:1901658 206 0.068
negative regulation of cell cycle process GO:0010948 69 0.068
Human Zebrafish Rat
negative regulation of cellular component organization GO:0051129 194 0.067
Human
regulation of proteasomal protein catabolic process GO:0061136 46 0.066
negative regulation of cell division GO:0051782 24 0.066
Human
dna biosynthetic process GO:0071897 22 0.064
Rat
proteasomal protein catabolic process GO:0010498 98 0.063
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.062
Zebrafish
cellular amino acid metabolic process GO:0006520 103 0.060
dna packaging GO:0006323 30 0.060
cellular response to radiation GO:0071478 28 0.060
nucleoside metabolic process GO:0009116 246 0.059
chromatin modification GO:0016568 187 0.058
purine nucleoside triphosphate catabolic process GO:0009146 203 0.057
cell differentiation involved in embryonic placenta development GO:0060706 26 0.056
negative regulation of organelle organization GO:0010639 90 0.056
Human
ribonucleoside metabolic process GO:0009119 245 0.055
endocytosis GO:0006897 168 0.052
centromere complex assembly GO:0034508 3 0.052
ribonucleoside triphosphate metabolic process GO:0009199 220 0.052
purine containing compound catabolic process GO:0072523 213 0.052
purine nucleoside catabolic process GO:0006152 205 0.051
meiotic chromosome segregation GO:0045132 19 0.051
nucleoside phosphate catabolic process GO:1901292 222 0.051
purine nucleoside metabolic process GO:0042278 241 0.050
glycosyl compound metabolic process GO:1901657 246 0.049
cellular amine metabolic process GO:0044106 44 0.049
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.049
carbohydrate derivative catabolic process GO:1901136 231 0.049
organic cyclic compound catabolic process GO:1901361 295 0.048
regulation of apoptotic signaling pathway GO:2001233 197 0.048
regulation of dna replication GO:0006275 17 0.048
purine ribonucleoside metabolic process GO:0046128 241 0.047
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.047
centrosome duplication GO:0051298 16 0.047
covalent chromatin modification GO:0016569 163 0.046
purine ribonucleotide catabolic process GO:0009154 208 0.046
chromatin assembly or disassembly GO:0006333 16 0.046
spindle assembly involved in female meiosis GO:0007056 3 0.045
purine nucleoside monophosphate metabolic process GO:0009126 81 0.045
response to ionizing radiation GO:0010212 42 0.045
regulation of meiosis i GO:0060631 7 0.044
nucleobase containing small molecule metabolic process GO:0055086 352 0.044
response to organonitrogen compound GO:0010243 246 0.043
Rat
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.043
Zebrafish Rat
receptor mediated endocytosis GO:0006898 51 0.043
spindle assembly involved in mitosis GO:0090307 4 0.042
organophosphate catabolic process GO:0046434 232 0.042
cell cycle comprising mitosis without cytokinesis GO:0033301 1 0.042
cell fate commitment GO:0045165 210 0.042
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.041
regulation of cellular protein catabolic process GO:1903362 61 0.040
chromosome separation GO:0051304 14 0.039
histone modification GO:0016570 159 0.039
multicellular organism growth GO:0035264 161 0.039
nucleotide metabolic process GO:0009117 332 0.039
amine metabolic process GO:0009308 45 0.039
regulation of proteolysis GO:0030162 164 0.038
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.038
ribonucleotide metabolic process GO:0009259 291 0.037
regulation of cellular component size GO:0032535 121 0.037
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.037
nucleoside triphosphate catabolic process GO:0009143 205 0.036
cellular nitrogen compound catabolic process GO:0044270 280 0.036
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.036
trophoblast giant cell differentiation GO:0060707 15 0.036
myosin filament organization GO:0031033 3 0.036
positive regulation of cell death GO:0010942 224 0.035
regulation of hydrolase activity GO:0051336 246 0.035
regulation of metaphase anaphase transition of cell cycle GO:1902099 9 0.035
macromolecule methylation GO:0043414 120 0.035
regulation of nuclear division GO:0051783 56 0.035
Human
mitotic recombination GO:0006312 3 0.034
ribonucleotide catabolic process GO:0009261 208 0.034
protein maturation GO:0051604 176 0.034
metaphase plate congression GO:0051310 2 0.034
nucleoside catabolic process GO:0009164 206 0.034
regulation of protein maturation GO:1903317 96 0.034
negative regulation of cellular protein metabolic process GO:0032269 247 0.034
synapsis GO:0007129 34 0.033
regulation of protein kinase activity GO:0045859 232 0.033
germ cell development GO:0007281 185 0.033
nucleoside monophosphate metabolic process GO:0009123 85 0.033
sister chromatid cohesion GO:0007062 12 0.033
dna conformation change GO:0071103 37 0.032
spindle organization GO:0007051 28 0.032
response to uv GO:0009411 44 0.032
regulation of mitotic sister chromatid separation GO:0010965 12 0.032
heterocycle catabolic process GO:0046700 280 0.031
negative regulation of protein metabolic process GO:0051248 282 0.031
nucleotide catabolic process GO:0009166 217 0.031
attachment of spindle microtubules to kinetochore GO:0008608 4 0.031
chromatin remodeling at centromere GO:0031055 2 0.031
purine containing compound metabolic process GO:0072521 311 0.031
cellularization GO:0007349 1 0.030
cellular response to organonitrogen compound GO:0071417 145 0.030
Rat
regulation of transferase activity GO:0051338 263 0.030
regulation of cell activation GO:0050865 289 0.030
intracellular mrna localization GO:0008298 4 0.030
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.029
chromatin assembly GO:0031497 13 0.029
chromosome organization involved in meiosis GO:0070192 39 0.029
ribonucleoside monophosphate catabolic process GO:0009158 57 0.029
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.029
regulation of chromosome segregation GO:0051983 21 0.028
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.027
positive regulation of apoptotic signaling pathway GO:2001235 95 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.027
spindle assembly involved in meiosis GO:0090306 4 0.027
cellular response to ionizing radiation GO:0071479 11 0.026
negative regulation of cellular protein catabolic process GO:1903363 22 0.026
regulation of centriole replication GO:0046599 1 0.026
negative regulation of phosphate metabolic process GO:0045936 184 0.026
reciprocal dna recombination GO:0035825 16 0.026
membrane organization GO:0061024 245 0.026
response to organic cyclic compound GO:0014070 198 0.025
Rat
nucleoside monophosphate catabolic process GO:0009125 59 0.025
dna modification GO:0006304 50 0.025
positive regulation of cellular amine metabolic process GO:0033240 5 0.025
purine nucleotide catabolic process GO:0006195 211 0.024
ribonucleoside triphosphate catabolic process GO:0009203 199 0.024
positive regulation of cell development GO:0010720 237 0.024
negative regulation of proteolysis GO:0045861 74 0.024
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 15 0.024
regulation of cellular amino acid metabolic process GO:0006521 5 0.024
regulation of cellular amine metabolic process GO:0033238 20 0.024
male meiosis i GO:0007141 16 0.024
regulation of protein catabolic process GO:0042176 108 0.023
regulation of sister chromatid cohesion GO:0007063 5 0.023
postreplication repair GO:0006301 5 0.023
centrosome cycle GO:0007098 23 0.023
Human
striated muscle myosin thick filament assembly GO:0071688 1 0.022
cilium morphogenesis GO:0060271 102 0.022
cellular response to gamma radiation GO:0071480 4 0.022
atp catabolic process GO:0006200 55 0.022
cell type specific apoptotic process GO:0097285 268 0.021
spermatid development GO:0007286 108 0.021
placenta development GO:0001890 140 0.021
dna catabolic process GO:0006308 19 0.020
cellular component assembly involved in morphogenesis GO:0010927 139 0.020
mitotic cytokinesis GO:0000281 4 0.020
protein processing GO:0016485 163 0.020
negative regulation of molecular function GO:0044092 258 0.020
regulation of dna dependent dna replication GO:0090329 8 0.020
blastocyst development GO:0001824 80 0.019
cell cycle g1 s phase transition GO:0044843 57 0.019
regulation of protein localization GO:0032880 231 0.019
spermatid differentiation GO:0048515 115 0.019
folic acid containing compound metabolic process GO:0006760 3 0.019
negative regulation of mitotic sister chromatid separation GO:2000816 7 0.019
protein secretion GO:0009306 111 0.019
mitotic sister chromatid separation GO:0051306 9 0.019
histone acetylation GO:0016573 41 0.019
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.018
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.018
female gamete generation GO:0007292 74 0.018
negative regulation of protein maturation GO:1903318 79 0.018
regulation of kinase activity GO:0043549 249 0.018
protein localization to organelle GO:0033365 185 0.018
rhythmic process GO:0048511 174 0.018
regulation of cytokinesis GO:0032465 5 0.017
positive regulation of protein modification process GO:0031401 299 0.017
aromatic compound catabolic process GO:0019439 286 0.017
positive regulation of hydrolase activity GO:0051345 148 0.017
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 22 0.017
axoneme assembly GO:0035082 15 0.017
regulation of t cell activation GO:0050863 170 0.017
nuclear dna replication GO:0033260 3 0.017
negative regulation of sister chromatid segregation GO:0033046 7 0.017
endomembrane system organization GO:0010256 147 0.017
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.017
kinetochore organization GO:0051383 2 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
positive regulation of histone h3 k9 methylation GO:0051574 4 0.016
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.016
regulation of cellular ketone metabolic process GO:0010565 66 0.016
reciprocal meiotic recombination GO:0007131 16 0.016
cell maturation GO:0048469 127 0.016
b cell activation GO:0042113 161 0.016
oogenesis GO:0048477 56 0.016
protein import into nucleus GO:0006606 95 0.016
regulation of peptidase activity GO:0052547 96 0.015
negative regulation of intracellular signal transduction GO:1902532 167 0.015
muscle cell differentiation GO:0042692 261 0.015
regulation of double strand break repair via homologous recombination GO:0010569 2 0.015
Human
methylation GO:0032259 134 0.015
peptidyl amino acid modification GO:0018193 336 0.015
myosin filament assembly GO:0031034 2 0.015
ossification GO:0001503 216 0.015
positive regulation of protein kinase activity GO:0045860 144 0.014
g1 s transition of mitotic cell cycle GO:0000082 57 0.014
positive regulation of mitotic cell cycle GO:0045931 41 0.014
fertilization GO:0009566 127 0.014
neuron migration GO:0001764 122 0.014
regulation of protein processing GO:0070613 96 0.014
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.014
positive regulation of nervous system development GO:0051962 221 0.014
positive regulation of cell cycle process GO:0090068 61 0.014
leukocyte differentiation GO:0002521 342 0.014
protein oligomerization GO:0051259 67 0.014
regulation of lymphocyte activation GO:0051249 240 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.014
lymphocyte differentiation GO:0030098 242 0.014
spindle assembly GO:0051225 13 0.014
protein modification by small protein conjugation GO:0032446 187 0.014
negative regulation of cell proliferation GO:0008285 296 0.014
mitotic cell cycle checkpoint GO:0007093 31 0.013
Zebrafish
regulation of cell size GO:0008361 72 0.013
dna catabolic process exonucleolytic GO:0000738 3 0.013
regulation of nuclear cell cycle dna replication GO:0033262 2 0.013
negative regulation of transferase activity GO:0051348 85 0.013
histone h3 k9 methylation GO:0051567 17 0.013
mitotic spindle organization GO:0007052 10 0.013
muscle cell development GO:0055001 133 0.013
wnt signaling pathway GO:0016055 188 0.013
histone h3 k9 dimethylation GO:0036123 4 0.013
meiotic cell cycle checkpoint GO:0033313 2 0.013
developmental maturation GO:0021700 193 0.012
response to hypoxia GO:0001666 58 0.012
oocyte maturation GO:0001556 18 0.012
dna methylation GO:0006306 43 0.012
regulation of transcription by chromatin organization GO:0034401 0 0.012
negative regulation of eosinophil degranulation GO:0043310 1 0.012
striated muscle cell development GO:0055002 125 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
negative regulation of protein processing GO:0010955 79 0.012
negative regulation of protein catabolic process GO:0042177 36 0.012
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 8 0.012
dna damage checkpoint GO:0000077 26 0.012
heterochromatin assembly GO:0031507 2 0.012
centrosome separation GO:0051299 4 0.012
Human
dna catabolic process endonucleolytic GO:0000737 15 0.012
myeloid cell differentiation GO:0030099 233 0.012
posttranscriptional regulation of gene expression GO:0010608 155 0.012
response to oxygen levels GO:0070482 62 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.012
positive regulation of kinase activity GO:0033674 155 0.011
rho protein signal transduction GO:0007266 32 0.011
cellular response to hormone stimulus GO:0032870 150 0.011
protein polyubiquitination GO:0000209 33 0.011
histone threonine phosphorylation GO:0035405 1 0.011
regulation of mitotic sister chromatid segregation GO:0033047 12 0.011
response to decreased oxygen levels GO:0036293 59 0.011
anatomical structure homeostasis GO:0060249 145 0.011
rac protein signal transduction GO:0016601 13 0.011
regulation of leukocyte apoptotic process GO:2000106 56 0.011
negative regulation of mitosis GO:0045839 10 0.011
Human
cellular response to cytokine stimulus GO:0071345 189 0.011
regulation of response to wounding GO:1903034 189 0.011
negative regulation of phosphorus metabolic process GO:0010563 184 0.011
regulation of canonical wnt signaling pathway GO:0060828 82 0.011
cellular response to oxidative stress GO:0034599 76 0.011
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.011
positive regulation of lymphocyte activation GO:0051251 140 0.011
mesodermal cell migration GO:0008078 4 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
organelle localization GO:0051640 179 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.010
negative regulation of cellular catabolic process GO:0031330 47 0.010
multi multicellular organism process GO:0044706 109 0.010
positive regulation of cellular catabolic process GO:0031331 148 0.010
regulation of cellular response to stress GO:0080135 159 0.010
Human
regulation of mitotic metaphase anaphase transition GO:0030071 8 0.010
male gonad development GO:0008584 88 0.010
gene silencing GO:0016458 38 0.010

Chek1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
breast cancer DOID:1612 0 0.060
thoracic cancer DOID:5093 0 0.060
cancer DOID:162 0 0.060
disease of cellular proliferation DOID:14566 0 0.060
organ system cancer DOID:0050686 0 0.060