Mus musculus

26 known processes

Chek2

CHK2 checkpoint homolog (S. pombe)

(Aliases: Cds1,Rad53,HUCDS1,CHK2)

Chek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.597
Human Fly
cellular response to dna damage stimulus GO:0006974 207 0.569
meiotic cell cycle process GO:1903046 77 0.430
Worm
mitotic cell cycle GO:0000278 195 0.342
Human Fly
mitotic chromosome condensation GO:0007076 1 0.319
dna repair GO:0006281 107 0.317
Human Fly
microtubule cytoskeleton organization GO:0000226 157 0.288
Human
dna recombination GO:0006310 92 0.261
metaphase plate congression GO:0051310 2 0.255
regulation of cell cycle process GO:0010564 160 0.220
Human Fly
nuclear division GO:0000280 158 0.192
Human Worm
nucleoside monophosphate metabolic process GO:0009123 85 0.189
cellular nitrogen compound catabolic process GO:0044270 280 0.169
nucleoside phosphate catabolic process GO:1901292 222 0.168
purine nucleotide metabolic process GO:0006163 302 0.167
organelle fission GO:0048285 170 0.164
Human Worm
meiotic nuclear division GO:0007126 115 0.160
Worm
intrinsic apoptotic signaling pathway GO:0097193 132 0.156
Human Fly
cell division GO:0051301 120 0.151
spindle assembly involved in mitosis GO:0090307 4 0.150
Human
purine ribonucleoside metabolic process GO:0046128 241 0.150
nucleobase containing small molecule metabolic process GO:0055086 352 0.150
regulation of cell cycle GO:0051726 281 0.141
Human Fly
nucleotide metabolic process GO:0009117 332 0.137
meiosis i GO:0007127 60 0.136
organophosphate catabolic process GO:0046434 232 0.136
macromolecule catabolic process GO:0009057 281 0.132
Human
regulation of organelle organization GO:0033043 289 0.132
regulation of cellular amine metabolic process GO:0033238 20 0.126
dna conformation change GO:0071103 37 0.124
double strand break repair GO:0006302 48 0.124
Human
purine nucleoside metabolic process GO:0042278 241 0.124
regulation of cellular catabolic process GO:0031329 242 0.124
glycosyl compound catabolic process GO:1901658 206 0.124
purine ribonucleotide metabolic process GO:0009150 290 0.123
purine nucleoside triphosphate metabolic process GO:0009144 226 0.123
ribonucleoside catabolic process GO:0042454 206 0.121
meiotic cell cycle GO:0051321 122 0.121
Worm
glycosyl compound metabolic process GO:1901657 246 0.120
organic cyclic compound catabolic process GO:1901361 295 0.120
cellular ketone metabolic process GO:0042180 84 0.118
nucleoside catabolic process GO:0009164 206 0.115
protein catabolic process GO:0030163 221 0.112
Human
ribonucleoside triphosphate catabolic process GO:0009203 199 0.111
heterocycle catabolic process GO:0046700 280 0.109
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.109
double strand break repair via homologous recombination GO:0000724 21 0.107
microtubule based process GO:0007017 236 0.106
Human
organelle assembly GO:0070925 177 0.105
Human
purine containing compound metabolic process GO:0072521 311 0.105
mitotic cell cycle process GO:1903047 159 0.101
Human Fly
nucleotide catabolic process GO:0009166 217 0.095
cellular amino acid metabolic process GO:0006520 103 0.095
regulation of mitotic cell cycle GO:0007346 126 0.095
Human Fly
ribonucleotide catabolic process GO:0009261 208 0.095
nucleoside phosphate metabolic process GO:0006753 338 0.094
ribonucleoside monophosphate catabolic process GO:0009158 57 0.093
ribose phosphate metabolic process GO:0019693 291 0.092
apoptotic signaling pathway GO:0097190 306 0.092
Human Fly
nucleoside triphosphate metabolic process GO:0009141 230 0.086
positive regulation of cellular amine metabolic process GO:0033240 5 0.086
purine nucleoside triphosphate catabolic process GO:0009146 203 0.085
amine metabolic process GO:0009308 45 0.085
response to radiation GO:0009314 165 0.084
cellular amine metabolic process GO:0044106 44 0.082
purine ribonucleoside catabolic process GO:0046130 205 0.082
aromatic compound catabolic process GO:0019439 286 0.079
carbohydrate derivative catabolic process GO:1901136 231 0.079
covalent chromatin modification GO:0016569 163 0.079
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.077
negative regulation of cell cycle GO:0045786 123 0.074
Human Fly
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.073
Human
negative regulation of cellular component organization GO:0051129 194 0.072
spindle assembly GO:0051225 13 0.072
Human
purine containing compound catabolic process GO:0072523 213 0.069
purine nucleotide catabolic process GO:0006195 211 0.068
nucleoside metabolic process GO:0009116 246 0.068
positive regulation of apoptotic process GO:0043065 217 0.066
Fly
organonitrogen compound catabolic process GO:1901565 264 0.066
purine nucleoside catabolic process GO:0006152 205 0.066
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.066
ribonucleoside triphosphate metabolic process GO:0009199 220 0.064
ribonucleoside metabolic process GO:0009119 245 0.063
regulation of cell division GO:0051302 76 0.062
atp catabolic process GO:0006200 55 0.062
regulation of cellular amino acid metabolic process GO:0006521 5 0.062
regulation of cellular ketone metabolic process GO:0010565 66 0.061
ribonucleotide metabolic process GO:0009259 291 0.061
purine ribonucleotide catabolic process GO:0009154 208 0.060
regulation of chromosome organization GO:0033044 83 0.059
chromatin modification GO:0016568 187 0.058
regulation of mitotic cell cycle phase transition GO:1901990 73 0.058
Human Fly
positive regulation of protein modification process GO:0031401 299 0.058
wnt signaling pathway GO:0016055 188 0.058
negative regulation of phosphorus metabolic process GO:0010563 184 0.056
ribonucleoside monophosphate metabolic process GO:0009161 80 0.056
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.056
chromatin organization GO:0006325 206 0.056
ras protein signal transduction GO:0007265 77 0.055
negative regulation of organelle organization GO:0010639 90 0.053
response to uv GO:0009411 44 0.053
establishment of organelle localization GO:0051656 122 0.052
nucleoside triphosphate catabolic process GO:0009143 205 0.052
regulation of microtubule based process GO:0032886 52 0.052
purine nucleoside monophosphate catabolic process GO:0009128 58 0.051
mitotic cytokinesis GO:0000281 4 0.051
recombinational repair GO:0000725 21 0.050
microtubule organizing center organization GO:0031023 28 0.049
nucleoside monophosphate catabolic process GO:0009125 59 0.049
centrosome cycle GO:0007098 23 0.048
dna replication GO:0006260 52 0.048
Human
purine nucleoside monophosphate metabolic process GO:0009126 81 0.047
cellular response to gamma radiation GO:0071480 4 0.047
Fly
regulation of protein localization GO:0032880 231 0.047
positive regulation of chromatin modification GO:1903310 28 0.047
leukocyte differentiation GO:0002521 342 0.047
homeostasis of number of cells GO:0048872 210 0.046
cellular response to radiation GO:0071478 28 0.044
Fly
negative regulation of cellular protein metabolic process GO:0032269 247 0.044
negative regulation of phosphate metabolic process GO:0045936 184 0.044
negative regulation of cell cycle phase transition GO:1901988 48 0.043
Human Fly
response to light stimulus GO:0009416 135 0.043
regulation of cytoskeleton organization GO:0051493 122 0.043
histone modification GO:0016570 159 0.042
mitotic sister chromatid segregation GO:0000070 14 0.041
attachment of spindle microtubules to kinetochore GO:0008608 4 0.041
positive regulation of hydrolase activity GO:0051345 148 0.041
Fly
negative regulation of protein metabolic process GO:0051248 282 0.040
male meiosis GO:0007140 37 0.040
chromosome segregation GO:0007059 48 0.039
Worm
cell fate commitment GO:0045165 210 0.038
maintenance of location GO:0051235 89 0.038
ubiquitin dependent protein catabolic process GO:0006511 129 0.038
small gtpase mediated signal transduction GO:0007264 97 0.037
regulation of protein kinase activity GO:0045859 232 0.036
regulation of transferase activity GO:0051338 263 0.036
atp metabolic process GO:0046034 75 0.035
cation transport GO:0006812 399 0.035
chromosome separation GO:0051304 14 0.034
regulation of kinase activity GO:0043549 249 0.034
cellular response to abiotic stimulus GO:0071214 56 0.033
Fly
oxidation reduction process GO:0055114 342 0.033
regulation of apoptotic signaling pathway GO:2001233 197 0.033
myeloid cell differentiation GO:0030099 233 0.033
anatomical structure homeostasis GO:0060249 145 0.032
dna packaging GO:0006323 30 0.032
dna catabolic process GO:0006308 19 0.032
organelle localization GO:0051640 179 0.032
regulation of histone modification GO:0031056 56 0.031
positive regulation of cell cycle GO:0045787 92 0.031
peptidyl amino acid modification GO:0018193 336 0.031
regulation of mitosis GO:0007088 29 0.031
positive regulation of proteolysis GO:0045862 85 0.030
Fly
male meiosis i GO:0007141 16 0.030
cytokinesis GO:0000910 17 0.029
multicellular organism growth GO:0035264 161 0.029
positive regulation of programmed cell death GO:0043068 218 0.029
Fly
female gamete generation GO:0007292 74 0.029
regulation of proteasomal protein catabolic process GO:0061136 46 0.028
positive regulation of cellular catabolic process GO:0031331 148 0.028
negative regulation of cell cycle process GO:0010948 69 0.028
Human Fly
protein modification by small protein conjugation or removal GO:0070647 207 0.028
negative regulation of intracellular signal transduction GO:1902532 167 0.028
lymphocyte apoptotic process GO:0070227 54 0.028
regulation of wnt signaling pathway GO:0030111 123 0.027
citrate metabolic process GO:0006101 3 0.027
centrosome separation GO:0051299 4 0.027
female meiosis chromosome segregation GO:0016321 1 0.027
regulation of chromatin modification GO:1903308 57 0.026
negative regulation of mitotic cell cycle GO:0045930 58 0.026
Human Fly
gonad development GO:0008406 141 0.026
male gamete generation GO:0048232 285 0.026
negative regulation of molecular function GO:0044092 258 0.026
b cell activation GO:0042113 161 0.026
response to organic cyclic compound GO:0014070 198 0.025
somatic diversification of immune receptors via somatic mutation GO:0002566 8 0.025
production of molecular mediator of immune response GO:0002440 103 0.025
cellular response to ionizing radiation GO:0071479 11 0.025
Fly
leukocyte homeostasis GO:0001776 79 0.025
regulation of chromatin organization GO:1902275 57 0.024
cellular response to oxidative stress GO:0034599 76 0.024
lymphocyte homeostasis GO:0002260 64 0.024
negative regulation of immune system process GO:0002683 209 0.024
cytokine production GO:0001816 319 0.024
germ cell development GO:0007281 185 0.024
Fly
regulation of cytokine production GO:0001817 266 0.024
positive regulation of protein phosphorylation GO:0001934 242 0.024
negative regulation of dna replication GO:0008156 4 0.023
Human
mitotic sister chromatid separation GO:0051306 9 0.023
negative regulation of phosphorylation GO:0042326 166 0.023
cellular protein catabolic process GO:0044257 155 0.023
Human
regulation of spindle organization GO:0090224 2 0.023
dna integrity checkpoint GO:0031570 28 0.022
Human Fly
regulation of hydrolase activity GO:0051336 246 0.022
Fly
negative regulation of transferase activity GO:0051348 85 0.022
positive regulation of cell death GO:0010942 224 0.022
Fly
methylation GO:0032259 134 0.022
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.022
regulation of nucleotide metabolic process GO:0006140 169 0.022
epithelial tube formation GO:0072175 130 0.022
regulation of defense response GO:0031347 233 0.022
epithelial cell proliferation GO:0050673 174 0.022
divalent metal ion transport GO:0070838 172 0.022
regulation of purine nucleotide metabolic process GO:1900542 169 0.021
response to oxidative stress GO:0006979 123 0.021
cell cycle checkpoint GO:0000075 47 0.021
Human Fly
response to ionizing radiation GO:0010212 42 0.021
cohesin localization to chromatin GO:0071921 1 0.021
lymphocyte mediated immunity GO:0002449 139 0.021
protein processing GO:0016485 163 0.021
Fly
muscle tissue development GO:0060537 308 0.021
cellular homeostasis GO:0019725 240 0.021
cellular lipid metabolic process GO:0044255 323 0.021
regulation of cellular protein catabolic process GO:1903362 61 0.020
mitotic nuclear division GO:0007067 48 0.020
Human
positive regulation of kinase activity GO:0033674 155 0.020
protein localization to organelle GO:0033365 185 0.020
cellular response to acid chemical GO:0071229 68 0.020
rho protein signal transduction GO:0007266 32 0.020
histone h3 k9 dimethylation GO:0036123 4 0.020
dna catabolic process endonucleolytic GO:0000737 15 0.020
hematopoietic progenitor cell differentiation GO:0002244 143 0.020
membrane organization GO:0061024 245 0.020
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.020
Human Fly
macromolecular complex disassembly GO:0032984 43 0.020
development of primary sexual characteristics GO:0045137 143 0.020
cellular response to cytokine stimulus GO:0071345 189 0.019
leukocyte apoptotic process GO:0071887 71 0.019
protein modification by small protein conjugation GO:0032446 187 0.019
regulation of cell cycle g2 m phase transition GO:1902749 10 0.019
cell type specific apoptotic process GO:0097285 268 0.019
regulation of chromosome segregation GO:0051983 21 0.019
regulation of binding GO:0051098 111 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.019
muscle cell differentiation GO:0042692 261 0.019
mitotic sister chromatid cohesion GO:0007064 1 0.018
regulation of cell activation GO:0050865 289 0.018
negative regulation of cell proliferation GO:0008285 296 0.018
blood vessel morphogenesis GO:0048514 285 0.018
response to organonitrogen compound GO:0010243 246 0.018
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.018
regulation of lymphocyte apoptotic process GO:0070228 41 0.018
dna endoreduplication GO:0042023 4 0.018
neural tube development GO:0021915 160 0.018
peptidyl lysine modification GO:0018205 77 0.018
gtp catabolic process GO:0006184 143 0.018
positive regulation of histone modification GO:0031058 28 0.018
regulation of protein catabolic process GO:0042176 108 0.018
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.018
proteasomal protein catabolic process GO:0010498 98 0.018
myeloid cell homeostasis GO:0002262 114 0.018
reactive oxygen species metabolic process GO:0072593 84 0.017
spermatogenesis GO:0007283 284 0.017
signal transduction in absence of ligand GO:0038034 55 0.017
cellular protein complex disassembly GO:0043624 36 0.017
regulation of cellular component biogenesis GO:0044087 181 0.017
lateral inhibition GO:0046331 1 0.017
oogenesis GO:0048477 56 0.017
protein ubiquitination GO:0016567 171 0.017
sensory perception GO:0007600 245 0.017
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.017
divalent inorganic cation transport GO:0072511 178 0.017
locomotory behavior GO:0007626 195 0.017
cellular response to lipid GO:0071396 145 0.017
positive regulation of chromosome organization GO:2001252 33 0.017
embryonic epithelial tube formation GO:0001838 130 0.017
protein maturation GO:0051604 176 0.017
Fly
chromosome organization involved in meiosis GO:0070192 39 0.017
modification dependent macromolecule catabolic process GO:0043632 133 0.017
erythrocyte differentiation GO:0030218 88 0.017
cellular response to external stimulus GO:0071496 88 0.017
chiasma assembly GO:0051026 6 0.016
regulation of leukocyte apoptotic process GO:2000106 56 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.016
leukocyte proliferation GO:0070661 172 0.016
cell cycle g1 s phase transition GO:0044843 57 0.016
regulation of protein maturation GO:1903317 96 0.016
positive regulation of histone h3 k9 methylation GO:0051574 4 0.016
regulation of epithelial cell proliferation GO:0050678 141 0.016
positive regulation of protein kinase activity GO:0045860 144 0.016
positive regulation of cell development GO:0010720 237 0.016
regulation of cell cycle phase transition GO:1901987 77 0.016
Human Fly
centrosome organization GO:0051297 26 0.016
positive regulation of organelle organization GO:0010638 128 0.016
positive regulation of nervous system development GO:0051962 221 0.016
regulation of nucleoside metabolic process GO:0009118 130 0.015
striated muscle tissue development GO:0014706 293 0.015
male meiosis chromosome segregation GO:0007060 3 0.015
microtubule polymerization or depolymerization GO:0031109 26 0.015
dna biosynthetic process GO:0071897 22 0.015
carbohydrate derivative biosynthetic process GO:1901137 183 0.015
lymphocyte proliferation GO:0046651 164 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.015
Human Fly
endomembrane system organization GO:0010256 147 0.015
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.015
skeletal muscle organ development GO:0060538 163 0.015
positive regulation of cell cycle process GO:0090068 61 0.015
regulation of microtubule cytoskeleton organization GO:0070507 37 0.015
posttranscriptional regulation of gene expression GO:0010608 155 0.015
Human
negative regulation of nuclear division GO:0051784 19 0.015
organonitrogen compound biosynthetic process GO:1901566 192 0.015
neuron death GO:0070997 154 0.015
cellular protein complex assembly GO:0043623 116 0.015
epithelial tube morphogenesis GO:0060562 303 0.015
dna modification GO:0006304 50 0.015
positive regulation of nucleotide metabolic process GO:0045981 114 0.015
innate immune response GO:0045087 157 0.014
positive regulation of nucleotide catabolic process GO:0030813 88 0.014
regulation of reactive oxygen species metabolic process GO:2000377 40 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
calcium ion transport GO:0006816 159 0.014
cellular chemical homeostasis GO:0055082 215 0.014
t cell differentiation GO:0030217 174 0.014
positive regulation of transferase activity GO:0051347 167 0.014
meiotic chromosome segregation GO:0045132 19 0.014
Worm
embryonic limb morphogenesis GO:0030326 126 0.014
response to inorganic substance GO:0010035 96 0.014
regulation of interleukin 1 alpha secretion GO:0050705 3 0.014
t cell homeostasis GO:0043029 35 0.014
positive regulation of histone methylation GO:0031062 16 0.014
neural tube formation GO:0001841 108 0.014
telomere maintenance GO:0000723 19 0.014
interleukin 8 production GO:0032637 4 0.014
gland development GO:0048732 330 0.013
regulation of proteolysis GO:0030162 164 0.013
Fly
regulation of lymphocyte activation GO:0051249 240 0.013
protein secretion GO:0009306 111 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
sister chromatid segregation GO:0000819 20 0.013
macromolecule methylation GO:0043414 120 0.013
synapsis GO:0007129 34 0.013
regulation of multi organism process GO:0043900 111 0.013
regulation of protein localization to nucleus GO:1900180 60 0.013
dna hypermethylation GO:0044026 3 0.013
transmembrane transport GO:0055085 412 0.013
digestive system development GO:0055123 200 0.013
extrinsic apoptotic signaling pathway GO:0097191 126 0.013
regulation of nucleotide catabolic process GO:0030811 122 0.013
developmental maturation GO:0021700 193 0.013
regulation of purine nucleotide catabolic process GO:0033121 122 0.013
rhythmic process GO:0048511 174 0.013
bone development GO:0060348 120 0.013
negative regulation of cell size GO:0045792 3 0.013
positive regulation of cytokine production GO:0001819 174 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
cellular macromolecule catabolic process GO:0044265 206 0.013
Human
somatic cell dna recombination GO:0016444 51 0.013
negative regulation of kinase activity GO:0033673 81 0.013
neuron apoptotic process GO:0051402 142 0.012
tube formation GO:0035148 140 0.012
regulation of mapk cascade GO:0043408 248 0.012
regulation of gtp catabolic process GO:0033124 113 0.012
double strand break repair via nonhomologous end joining GO:0006303 10 0.012
g1 s transition of mitotic cell cycle GO:0000082 57 0.012
cellular ion homeostasis GO:0006873 165 0.012
somatic diversification of immunoglobulins GO:0016445 43 0.012
cellular response to organonitrogen compound GO:0071417 145 0.012
inflammatory response GO:0006954 244 0.012
lymphocyte differentiation GO:0030098 242 0.012
heterochromatin organization GO:0070828 4 0.012
regulation of interleukin 8 production GO:0032677 3 0.012
telomere capping GO:0016233 4 0.012
guanosine containing compound catabolic process GO:1901069 144 0.012
gtp metabolic process GO:0046039 144 0.012
regulation of neuron differentiation GO:0045664 281 0.012
protein localization to chromatin GO:0071168 3 0.012
negative regulation of wnt signaling pathway GO:0030178 73 0.012
negative regulation of cytoskeleton organization GO:0051494 36 0.012
negative regulation of protein phosphorylation GO:0001933 126 0.012
regulation of establishment of protein localization GO:0070201 181 0.012
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.012
t cell activation GO:0042110 289 0.012
spindle midzone assembly GO:0051255 1 0.012
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.012
b cell differentiation GO:0030183 78 0.012
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.012
cellular response to biotic stimulus GO:0071216 92 0.012
positive regulation of interleukin 8 production GO:0032757 2 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.011
spindle organization GO:0007051 28 0.011
Human
regulation of anatomical structure size GO:0090066 178 0.011
spindle assembly involved in female meiosis GO:0007056 3 0.011
endocytosis GO:0006897 168 0.011
cell maturation GO:0048469 127 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
regulation of cysteine type endopeptidase activity GO:2000116 65 0.011
Fly
regulation of canonical wnt signaling pathway GO:0060828 82 0.011
regulation of t cell activation GO:0050863 170 0.011
t cell apoptotic process GO:0070231 39 0.011
reciprocal dna recombination GO:0035825 16 0.011
regulation of cell projection organization GO:0031344 206 0.011
digestive tract morphogenesis GO:0048546 147 0.011
organophosphate biosynthetic process GO:0090407 122 0.011
response to oxygen levels GO:0070482 62 0.011
intestinal epithelial structure maintenance GO:0060729 4 0.011
nucleotide biosynthetic process GO:0009165 78 0.011
negative regulation of protein modification process GO:0031400 163 0.011
regulation of cell migration GO:0030334 219 0.011
tricarboxylic acid metabolic process GO:0072350 5 0.011
blood circulation GO:0008015 195 0.011
regulation of double strand break repair via homologous recombination GO:0010569 2 0.011
carbohydrate homeostasis GO:0033500 128 0.011
striated muscle cell development GO:0055002 125 0.011
positive regulation of apoptotic signaling pathway GO:2001235 95 0.011
response to acid chemical GO:0001101 111 0.011
cell cycle arrest GO:0007050 37 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
axonogenesis GO:0007409 274 0.011
regulation of cytoplasmic transport GO:1903649 112 0.011
regionalization GO:0003002 337 0.011
rna dependent dna replication GO:0006278 3 0.011
sequestering of calcium ion GO:0051208 18 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
fibroblast proliferation GO:0048144 35 0.011
lipid biosynthetic process GO:0008610 179 0.011
digestive tract development GO:0048565 190 0.010
negative regulation of homeostatic process GO:0032845 71 0.010
regulation of cellular response to stress GO:0080135 159 0.010
Fly
canonical wnt signaling pathway GO:0060070 130 0.010
cellular response to light stimulus GO:0071482 19 0.010
rna interference GO:0016246 2 0.010
regulation of intracellular protein transport GO:0033157 82 0.010
asymmetric neuroblast division GO:0055059 1 0.010
cellularization GO:0007349 1 0.010
angiogenesis GO:0001525 201 0.010
cell cycle g2 m phase transition GO:0044839 20 0.010
Human
mitotic recombination GO:0006312 3 0.010
skeletal system development GO:0001501 356 0.010
response to growth factor GO:0070848 198 0.010
cilium morphogenesis GO:0060271 102 0.010
striated muscle myosin thick filament assembly GO:0071688 1 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
negative regulation of protein catabolic process GO:0042177 36 0.010
protein acylation GO:0043543 64 0.010
somatic hypermutation of immunoglobulin genes GO:0016446 7 0.010
cell growth GO:0016049 130 0.010
mapk cascade GO:0000165 281 0.010
translesion synthesis GO:0019985 1 0.010

Chek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.086
Human
disease of cellular proliferation DOID:14566 0 0.086
Human
organ system cancer DOID:0050686 0 0.086
Human
thoracic cancer DOID:5093 0 0.032
Human
breast cancer DOID:1612 0 0.018
Human
congenital hypoplastic anemia DOID:1342 0 0.015
immune system disease DOID:2914 0 0.015
aplastic anemia DOID:12449 0 0.015
disease of anatomical entity DOID:7 0 0.015
bone marrow disease DOID:4961 0 0.015
anemia DOID:2355 0 0.015
hematopoietic system disease DOID:74 0 0.015
gastrointestinal system cancer DOID:3119 0 0.015
intestinal cancer DOID:10155 0 0.015
large intestine cancer DOID:5672 0 0.011
immune system cancer DOID:0060083 0 0.010