Mus musculus

85 known processes

Cops2

COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)

(Aliases: Sgn2,C85265,alien-like,Csn2,AI315723,Trip15)

Cops2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macromolecule catabolic process GO:0009057 281 0.829
ubiquitin dependent protein catabolic process GO:0006511 129 0.716
proteasomal protein catabolic process GO:0010498 98 0.715
cellular protein catabolic process GO:0044257 155 0.623
glycosyl compound catabolic process GO:1901658 206 0.474
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.459
protein neddylation GO:0045116 1 0.454
ribonucleotide catabolic process GO:0009261 208 0.442
protein catabolic process GO:0030163 221 0.436
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.360
modification dependent protein catabolic process GO:0019941 133 0.357
cellular macromolecule catabolic process GO:0044265 206 0.357
mitotic cell cycle GO:0000278 195 0.343
cellular response to dna damage stimulus GO:0006974 207 0.335
regulation of cell cycle GO:0051726 281 0.328
chromosome segregation GO:0007059 48 0.286
nucleotide catabolic process GO:0009166 217 0.284
purine nucleotide catabolic process GO:0006195 211 0.258
guanosine containing compound metabolic process GO:1901068 144 0.237
regulation of mitotic cell cycle GO:0007346 126 0.235
regulation of cell cycle process GO:0010564 160 0.234
multicellular organismal protein catabolic process GO:0044254 1 0.225
purine ribonucleotide metabolic process GO:0009150 290 0.225
positive regulation of cellular catabolic process GO:0031331 148 0.220
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.208
protein modification by small protein conjugation or removal GO:0070647 207 0.197
Human
glycosyl compound metabolic process GO:1901657 246 0.194
carbohydrate derivative catabolic process GO:1901136 231 0.192
ribonucleoside triphosphate catabolic process GO:0009203 199 0.191
ribonucleoside catabolic process GO:0042454 206 0.190
purine ribonucleoside catabolic process GO:0046130 205 0.184
purine ribonucleotide catabolic process GO:0009154 208 0.173
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.170
establishment of protein localization to organelle GO:0072594 118 0.170
protein targeting GO:0006605 143 0.163
purine ribonucleoside metabolic process GO:0046128 241 0.162
nucleotide metabolic process GO:0009117 332 0.154
organonitrogen compound catabolic process GO:1901565 264 0.151
modification dependent macromolecule catabolic process GO:0043632 133 0.144
protein localization to organelle GO:0033365 185 0.142
regulation of protein localization GO:0032880 231 0.141
nucleoside triphosphate metabolic process GO:0009141 230 0.133
purine containing compound catabolic process GO:0072523 213 0.132
organophosphate catabolic process GO:0046434 232 0.131
nucleoside catabolic process GO:0009164 206 0.127
regulation of protein catabolic process GO:0042176 108 0.121
ribonucleotide metabolic process GO:0009259 291 0.119
nucleoside phosphate catabolic process GO:1901292 222 0.115
aromatic compound catabolic process GO:0019439 286 0.110
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.109
ribonucleoside metabolic process GO:0009119 245 0.105
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.103
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.101
dna metabolic process GO:0006259 303 0.100
dna repair GO:0006281 107 0.100
nucleoside metabolic process GO:0009116 246 0.099
purine nucleoside catabolic process GO:0006152 205 0.094
organic cyclic compound catabolic process GO:1901361 295 0.092
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.091
regulation of intracellular protein transport GO:0033157 82 0.082
trna processing GO:0008033 11 0.081
regulation of cellular catabolic process GO:0031329 242 0.079
cellular nitrogen compound catabolic process GO:0044270 280 0.079
maintenance of location GO:0051235 89 0.078
negative regulation of cell cycle GO:0045786 123 0.075
negative regulation of mitotic cell cycle GO:0045930 58 0.072
mitotic cell cycle process GO:1903047 159 0.071
ribose phosphate metabolic process GO:0019693 291 0.071
translational initiation GO:0006413 24 0.068
positive regulation of cell death GO:0010942 224 0.068
organelle fission GO:0048285 170 0.067
establishment of organelle localization GO:0051656 122 0.067
ras protein signal transduction GO:0007265 77 0.066
regulation of transcription factor import into nucleus GO:0042990 24 0.066
organelle assembly GO:0070925 177 0.065
ribonucleoside triphosphate metabolic process GO:0009199 220 0.064
development of primary sexual characteristics GO:0045137 143 0.064
atp catabolic process GO:0006200 55 0.061
positive regulation of apoptotic process GO:0043065 217 0.060
organelle localization GO:0051640 179 0.059
positive regulation of cellular protein catabolic process GO:1903364 34 0.059
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.058
negative regulation of protein metabolic process GO:0051248 282 0.058
protein import GO:0017038 101 0.057
nucleoside phosphate metabolic process GO:0006753 338 0.056
mitotic g2 dna damage checkpoint GO:0007095 8 0.053
purine nucleotide metabolic process GO:0006163 302 0.051
regulation of protein transport GO:0051223 163 0.050
positive regulation of protein catabolic process GO:0045732 60 0.050
stem cell differentiation GO:0048863 268 0.050
regulation of cell cycle phase transition GO:1901987 77 0.049
regulation of cell migration GO:0030334 219 0.049
positive regulation of programmed cell death GO:0043068 218 0.048
regulation of cytoplasmic transport GO:1903649 112 0.047
protein digestion GO:0044256 1 0.047
nucleoside triphosphate catabolic process GO:0009143 205 0.046
cytoplasmic transport GO:0016482 234 0.046
neuron migration GO:0001764 122 0.045
regulation of establishment of protein localization GO:0070201 181 0.045
regulation of protein targeting GO:1903533 61 0.045
ribonucleoside monophosphate metabolic process GO:0009161 80 0.045
guanosine containing compound catabolic process GO:1901069 144 0.045
stem cell maintenance GO:0019827 130 0.045
trna wobble base modification GO:0002097 2 0.044
protein modification by small protein conjugation GO:0032446 187 0.043
gtp metabolic process GO:0046039 144 0.043
dna integrity checkpoint GO:0031570 28 0.043
negative regulation of cell proliferation GO:0008285 296 0.042
intracellular protein transport GO:0006886 204 0.042
purine containing compound metabolic process GO:0072521 311 0.041
positive regulation of transferase activity GO:0051347 167 0.039
heterocycle catabolic process GO:0046700 280 0.038
positive regulation of proteolysis GO:0045862 85 0.038
protein folding GO:0006457 28 0.038
purine nucleoside metabolic process GO:0042278 241 0.037
positive regulation of ras gtpase activity GO:0032320 65 0.037
muscle tissue development GO:0060537 308 0.036
lateral inhibition GO:0046331 1 0.035
protein dna complex subunit organization GO:0071824 28 0.035
positive regulation of cell cycle GO:0045787 92 0.035
retrograde transport endosome to golgi GO:0042147 2 0.033
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.033
regulation of protein complex assembly GO:0043254 83 0.030
response to inorganic substance GO:0010035 96 0.030
developmental maturation GO:0021700 193 0.030
positive regulation of cell cycle process GO:0090068 61 0.030
negative regulation of protein modification process GO:0031400 163 0.030
cellular ketone metabolic process GO:0042180 84 0.030
regulation of proteolysis GO:0030162 164 0.029
purine nucleoside triphosphate metabolic process GO:0009144 226 0.029
regulation of cell division GO:0051302 76 0.029
regulation of protein kinase activity GO:0045859 232 0.029
cell division GO:0051301 120 0.028
Worm
membrane fusion GO:0061025 38 0.028
negative regulation of cellular protein metabolic process GO:0032269 247 0.028
negative regulation of cell cycle phase transition GO:1901988 48 0.028
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.028
striated muscle cell development GO:0055002 125 0.028
endocytosis GO:0006897 168 0.028
cellular amine metabolic process GO:0044106 44 0.027
response to organonitrogen compound GO:0010243 246 0.026
protein modification by small protein removal GO:0070646 21 0.026
Human
purine nucleoside triphosphate catabolic process GO:0009146 203 0.026
regulation of protein processing GO:0070613 96 0.026
regulation of cellular protein catabolic process GO:1903362 61 0.025
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.025
nucleobase containing small molecule metabolic process GO:0055086 352 0.025
negative regulation of intracellular signal transduction GO:1902532 167 0.025
chromatin modification GO:0016568 187 0.025
response to organic cyclic compound GO:0014070 198 0.024
positive regulation of nucleotide catabolic process GO:0030813 88 0.024
cellular response to organonitrogen compound GO:0071417 145 0.024
positive regulation of hydrolase activity GO:0051345 148 0.024
regulation of kinase activity GO:0043549 249 0.023
positive regulation of mitotic cell cycle GO:0045931 41 0.023
regulation of cellular component size GO:0032535 121 0.023
stem cell development GO:0048864 219 0.023
gene silencing GO:0016458 38 0.022
regulation of ras gtpase activity GO:0032318 88 0.022
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.022
regulation of mapk cascade GO:0043408 248 0.022
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 10 0.021
ossification GO:0001503 216 0.021
centrosome duplication GO:0051298 16 0.021
cell cycle g1 s phase transition GO:0044843 57 0.021
muscle cell differentiation GO:0042692 261 0.021
dna dependent dna replication GO:0006261 24 0.021
mitotic nuclear division GO:0007067 48 0.021
amp metabolic process GO:0046033 4 0.021
nuclear import GO:0051170 95 0.021
positive regulation of intracellular protein transport GO:0090316 42 0.021
amine metabolic process GO:0009308 45 0.021
negative regulation of cell cycle process GO:0010948 69 0.020
dna damage checkpoint GO:0000077 26 0.020
meiotic cell cycle process GO:1903046 77 0.020
cell maturation GO:0048469 127 0.020
dna replication GO:0006260 52 0.020
cellular amino acid metabolic process GO:0006520 103 0.019
regionalization GO:0003002 337 0.019
regulation of apoptotic signaling pathway GO:2001233 197 0.019
microtubule based process GO:0007017 236 0.019
regulation of cellular response to stress GO:0080135 159 0.019
immune effector process GO:0002252 321 0.019
regulation of intracellular transport GO:0032386 159 0.018
positive regulation of cell cycle phase transition GO:1901989 17 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.018
lipid localization GO:0010876 126 0.018
regulation of nucleotide metabolic process GO:0006140 169 0.018
developmental growth involved in morphogenesis GO:0060560 138 0.018
ribosomal small subunit biogenesis GO:0042274 4 0.018
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.018
multicellular organismal macromolecule catabolic process GO:0044266 1 0.018
nfat protein import into nucleus GO:0051531 6 0.018
chromatin organization GO:0006325 206 0.017
protein oligomerization GO:0051259 67 0.017
neuronal action potential GO:0019228 54 0.017
trna metabolic process GO:0006399 11 0.017
g2 dna damage checkpoint GO:0031572 8 0.017
regulation of cell adhesion GO:0030155 154 0.017
cellularization GO:0007349 1 0.017
regulation of transferase activity GO:0051338 263 0.017
nucleoside monophosphate metabolic process GO:0009123 85 0.017
purine nucleoside monophosphate metabolic process GO:0009126 81 0.017
regulation of system process GO:0044057 200 0.016
body morphogenesis GO:0010171 45 0.016
atp metabolic process GO:0046034 75 0.016
negative regulation of molecular function GO:0044092 258 0.016
regulation of organelle organization GO:0033043 289 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
positive regulation of apoptotic signaling pathway GO:2001235 95 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.015
positive regulation of protein kinase activity GO:0045860 144 0.015
insulin receptor signaling pathway GO:0008286 49 0.015
response to uv GO:0009411 44 0.015
lung field specification GO:0060424 3 0.015
regulation of cellular response to growth factor stimulus GO:0090287 82 0.015
regulation of nucleocytoplasmic transport GO:0046822 73 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.014
mitotic cell cycle checkpoint GO:0007093 31 0.014
negative regulation of tor signaling GO:0032007 13 0.014
gtp catabolic process GO:0006184 143 0.014
genitalia development GO:0048806 37 0.014
muscle cell development GO:0055001 133 0.014
protein ubiquitination GO:0016567 171 0.014
negative regulation of immune system process GO:0002683 209 0.014
positive regulation of nfat protein import into nucleus GO:0051533 1 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
protein import into nucleus GO:0006606 95 0.014
posttranscriptional regulation of gene expression GO:0010608 155 0.013
positive regulation of cell adhesion GO:0045785 80 0.013
striated muscle tissue development GO:0014706 293 0.013
nucleoside monophosphate catabolic process GO:0009125 59 0.013
regulation of hydrolase activity GO:0051336 246 0.013
er associated ubiquitin dependent protein catabolic process GO:0030433 10 0.013
mitotic sister chromatid segregation GO:0000070 14 0.013
tor signaling GO:0031929 21 0.013
negative regulation of protein phosphorylation GO:0001933 126 0.013
rna interference GO:0016246 2 0.013
male gamete generation GO:0048232 285 0.013
positive regulation of protein autophosphorylation GO:0031954 4 0.013
regulation of epithelial cell proliferation GO:0050678 141 0.013
segmentation GO:0035282 93 0.012
positive regulation of dna templated transcription elongation GO:0032786 2 0.012
positive regulation of cell migration GO:0030335 109 0.012
cardiocyte differentiation GO:0035051 87 0.012
regulation of anatomical structure size GO:0090066 178 0.012
regulation of jnk cascade GO:0046328 62 0.012
positive regulation of dna templated transcription initiation GO:2000144 5 0.012
protein deubiquitination GO:0016579 19 0.012
regulation of protein import into nucleus GO:0042306 52 0.012
neuron maturation GO:0042551 29 0.012
forebrain development GO:0030900 302 0.012
circulatory system process GO:0003013 197 0.012
regulation of cell motility GO:2000145 236 0.012
regulation of ras protein signal transduction GO:0046578 114 0.012
regulation of vesicle mediated transport GO:0060627 139 0.012
cytokinesis GO:0000910 17 0.012
Worm
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.011
transforming growth factor beta2 production GO:0032906 2 0.011
establishment of spindle localization GO:0051293 19 0.011
positive regulation of protein complex assembly GO:0031334 45 0.011
cell adhesion GO:0007155 329 0.011
wnt signaling pathway GO:0016055 188 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
maintenance of location in cell GO:0051651 24 0.011
meiotic cell cycle GO:0051321 122 0.011
regulation of cellular ketone metabolic process GO:0010565 66 0.011
telencephalon development GO:0021537 186 0.011
attachment of spindle microtubules to kinetochore GO:0008608 4 0.011
amp biosynthetic process GO:0006167 2 0.011
establishment of protein localization to endoplasmic reticulum GO:0072599 2 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.011
blastocyst development GO:0001824 80 0.011
regulation of vacuole organization GO:0044088 4 0.011
spindle organization GO:0007051 28 0.011
endoplasmic reticulum tubular network organization GO:0071786 1 0.010
regulation of microtubule based process GO:0032886 52 0.010
positive regulation of phospholipase activity GO:0010518 3 0.010
spermatid development GO:0007286 108 0.010
regulation of nucleotide catabolic process GO:0030811 122 0.010
single organism nuclear import GO:1902593 95 0.010
negative regulation of protein processing GO:0010955 79 0.010
g1 s transition of mitotic cell cycle GO:0000082 57 0.010
protein maturation GO:0051604 176 0.010
response to transforming growth factor beta GO:0071559 88 0.010

Cops2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.071
retinal degeneration DOID:8466 0 0.071
sensory system disease DOID:0050155 0 0.071
disease of anatomical entity DOID:7 0 0.071
eye and adnexa disease DOID:1492 0 0.071
nervous system disease DOID:863 0 0.071
eye disease DOID:5614 0 0.071
central nervous system disease DOID:331 0 0.017
neurodegenerative disease DOID:1289 0 0.017