Mus musculus

0 known processes

Ctla4

cytotoxic T-lymphocyte-associated protein 4

(Aliases: Cd152,Ly-56,Ctla-4)

Ctla4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of defense response GO:0031347 233 0.814
Mouse
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.743
Human Mouse
immune effector process GO:0002252 321 0.694
Mouse
lymphocyte mediated immunity GO:0002449 139 0.638
Mouse
regulation of interleukin 2 production GO:0032663 28 0.636
Mouse
interleukin 2 production GO:0032623 33 0.587
Mouse
regulation of cell activation GO:0050865 289 0.563
Human Mouse
t cell differentiation GO:0030217 174 0.557
Human Mouse
cytokine production GO:0001816 319 0.526
Mouse
negative regulation of immune system process GO:0002683 209 0.496
Human
cellular response to cytokine stimulus GO:0071345 189 0.496
interleukin 12 secretion GO:0072610 3 0.478
positive regulation of cytokine production GO:0001819 174 0.476
Mouse
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.471
Mouse
leukocyte proliferation GO:0070661 172 0.443
Human Mouse
regulation of monocyte chemotaxis GO:0090025 3 0.424
regulation of leukocyte proliferation GO:0070663 121 0.410
Human Mouse
leukocyte differentiation GO:0002521 342 0.410
Human Mouse
lymphocyte differentiation GO:0030098 242 0.400
Human Mouse
regulation of cytokine production GO:0001817 266 0.382
Mouse
positive regulation of defense response GO:0031349 124 0.375
Mouse
positive regulation of t cell activation GO:0050870 101 0.373
Mouse
t cell activation GO:0042110 289 0.361
Human Mouse
immune response activating signal transduction GO:0002757 116 0.349
Human Mouse
regulation of t cell activation GO:0050863 170 0.343
Human Mouse
adaptive immune response GO:0002250 155 0.338
Mouse
leukocyte mediated immunity GO:0002443 174 0.328
Mouse
regulation of protein transport GO:0051223 163 0.323
positive regulation of lymphocyte proliferation GO:0050671 70 0.320
Mouse
cytokine secretion GO:0050663 72 0.318
cellular amino acid metabolic process GO:0006520 103 0.316
positive regulation of t cell proliferation GO:0042102 52 0.315
Mouse
inflammatory response GO:0006954 244 0.314
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.309
Mouse
regulation of t cell anergy GO:0002667 4 0.298
regulation of cellular amine metabolic process GO:0033238 20 0.287
antigen receptor mediated signaling pathway GO:0050851 64 0.283
Human Mouse
positive regulation of leukocyte proliferation GO:0070665 73 0.275
Mouse
regulation of alpha beta t cell activation GO:0046634 53 0.275
Mouse
activation of immune response GO:0002253 138 0.262
Human Mouse
regulation of secretion by cell GO:1903530 249 0.261
positive regulation of lymphocyte activation GO:0051251 140 0.256
Mouse
t cell proliferation GO:0042098 120 0.248
Mouse
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.245
Mouse
regulation of lymphocyte proliferation GO:0050670 117 0.244
Human Mouse
mature dendritic cell differentiation GO:0097029 3 0.242
positive regulation of t cell costimulation GO:2000525 2 0.237
response to molecule of bacterial origin GO:0002237 143 0.235
alpha beta t cell proliferation GO:0046633 21 0.233
Mouse
t cell differentiation in thymus GO:0033077 77 0.227
Mouse
defense response to other organism GO:0098542 197 0.226
positive regulation of cellular amine metabolic process GO:0033240 5 0.225
gliogenesis GO:0042063 141 0.221
t cell anergy GO:0002870 4 0.220
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.217
regulation of innate immune response GO:0045088 91 0.215
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.213
regulation of interferon gamma production GO:0032649 57 0.210
regulation of cytokine biosynthetic process GO:0042035 59 0.207
Mouse
regulation of inflammatory response GO:0050727 147 0.207
Mouse
negative regulation of protein metabolic process GO:0051248 282 0.204
alpha beta t cell activation GO:0046631 91 0.203
Mouse
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.200
positive regulation of immune effector process GO:0002699 107 0.197
Mouse
positive regulation of cell activation GO:0050867 158 0.195
Mouse
regulation of lymphocyte anergy GO:0002911 4 0.195
regulation of protein localization GO:0032880 231 0.193
cell type specific apoptotic process GO:0097285 268 0.192
eosinophil mediated immunity GO:0002447 1 0.191
immunoglobulin production GO:0002377 73 0.189
Mouse
regulation of alpha beta t cell proliferation GO:0046640 18 0.184
Mouse
t cell costimulation GO:0031295 14 0.180
Mouse
myeloid cell differentiation GO:0030099 233 0.179
positive regulation of innate immune response GO:0045089 80 0.178
protein processing GO:0016485 163 0.178
amine metabolic process GO:0009308 45 0.172
lymphocyte proliferation GO:0046651 164 0.170
Human Mouse
protein secretion GO:0009306 111 0.168
response to lipopolysaccharide GO:0032496 128 0.167
positive regulation of alpha beta t cell activation GO:0046635 39 0.166
Mouse
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.164
Human Mouse
leukocyte activation involved in immune response GO:0002366 126 0.161
Mouse
positive regulation of cell death GO:0010942 224 0.159
Human
regulation of b cell mediated immunity GO:0002712 37 0.158
Mouse
dna recombination GO:0006310 92 0.154
Mouse
negative regulation of cellular protein metabolic process GO:0032269 247 0.153
positive regulation of monocyte chemotaxis GO:0090026 2 0.153
regulation of leukocyte mediated immunity GO:0002703 104 0.152
Mouse
chemotaxis GO:0006935 247 0.151
negative regulation of macrophage apoptotic process GO:2000110 3 0.146
regulation of lymphocyte activation GO:0051249 240 0.146
Human Mouse
immune response regulating signaling pathway GO:0002764 125 0.146
Human Mouse
positive regulation of programmed cell death GO:0043068 218 0.145
Human
positive regulation of inflammatory response GO:0050729 47 0.145
Mouse
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.144
regulation of establishment of protein localization GO:0070201 181 0.143
apoptotic signaling pathway GO:0097190 306 0.141
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.140
b cell activation GO:0042113 161 0.139
Human Mouse
positive regulation of protein transport GO:0051222 93 0.139
cellular ketone metabolic process GO:0042180 84 0.138
protein maturation GO:0051604 176 0.138
regulation of lymphocyte differentiation GO:0045619 107 0.138
Human
negative regulation of hydrolase activity GO:0051346 71 0.138
sequestering of calcium ion GO:0051208 18 0.137
negative thymic t cell selection GO:0045060 12 0.135
Mouse
negative regulation of interleukin 2 biosynthetic process GO:0045085 3 0.133
regulation of cytokine secretion GO:0050707 61 0.130
g protein coupled receptor signaling pathway GO:0007186 243 0.130
regulation of vesicle mediated transport GO:0060627 139 0.128
immunoglobulin mediated immune response GO:0016064 69 0.126
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.125
interleukin 2 biosynthetic process GO:0042094 15 0.125
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.123
negative regulation of cell activation GO:0050866 111 0.122
Human
cellular response to lipopolysaccharide GO:0071222 77 0.118
natural killer cell activation GO:0030101 44 0.118
cation transport GO:0006812 399 0.117
eosinophil activation involved in immune response GO:0002278 1 0.116
regulation of immunoglobulin production GO:0002637 42 0.115
Mouse
lymphocyte costimulation GO:0031294 15 0.115
Mouse
positive regulation of t cell anergy GO:0002669 4 0.114
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.112
Mouse
positive regulation of apoptotic process GO:0043065 217 0.112
Human
interferon gamma production GO:0032609 67 0.112
regulation of t cell costimulation GO:2000523 2 0.110
morphogenesis of a branching epithelium GO:0061138 193 0.109
interleukin 1 beta secretion GO:0050702 16 0.109
negative regulation of defense response GO:0031348 77 0.109
glycoprotein biosynthetic process GO:0009101 89 0.108
divalent metal ion transport GO:0070838 172 0.106
innate immune response GO:0045087 157 0.106
myeloid leukocyte differentiation GO:0002573 119 0.105
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.103
regulation of chemotaxis GO:0050920 53 0.102
regulation of kinase activity GO:0043549 249 0.102
negative regulation of t cell activation GO:0050868 65 0.102
Human
production of molecular mediator of immune response GO:0002440 103 0.100
Mouse
positive regulation of cell killing GO:0031343 33 0.100
regulation of t cell extravasation GO:2000407 3 0.100
helper t cell chemotaxis GO:0035704 1 0.099
regulation of cell killing GO:0031341 40 0.098
regulation of interleukin 2 biosynthetic process GO:0045076 13 0.098
Mouse
negative regulation of leukocyte mediated immunity GO:0002704 29 0.098
branching morphogenesis of an epithelial tube GO:0048754 159 0.098
natural killer cell inhibitory signaling pathway GO:0002769 2 0.098
negative regulation of secretion by cell GO:1903531 54 0.097
regulation of angiogenesis GO:0045765 81 0.097
cellular amine metabolic process GO:0044106 44 0.095
positive regulation of interferon gamma production GO:0032729 39 0.095
sequestering of metal ion GO:0051238 19 0.095
cell killing GO:0001906 67 0.094
immune complex clearance GO:0002434 2 0.094
regulation of dendritic cell chemotaxis GO:2000508 1 0.093
regulation of adaptive immune response GO:0002819 90 0.093
Mouse
epithelial tube morphogenesis GO:0060562 303 0.093
calcium ion transport GO:0006816 159 0.093
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.092
eosinophil activation GO:0043307 1 0.092
striated muscle tissue development GO:0014706 293 0.091
regulation of eosinophil migration GO:2000416 2 0.090
regulation of membrane potential GO:0042391 192 0.089
cdc42 protein signal transduction GO:0032488 0 0.089
peptidyl tyrosine modification GO:0018212 145 0.089
cellular response to interleukin 15 GO:0071350 2 0.088
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.088
regulation of intracellular transport GO:0032386 159 0.088
regulation of protein secretion GO:0050708 82 0.086
regulation of secretion GO:0051046 274 0.085
cytokine biosynthetic process GO:0042089 68 0.085
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.085
regulation of hydrolase activity GO:0051336 246 0.085
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.085
Mouse
regulation of muscle tissue development GO:1901861 97 0.084
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.083
purine nucleoside metabolic process GO:0042278 241 0.082
leukocyte mediated cytotoxicity GO:0001909 62 0.082
positive regulation of lymphocyte anergy GO:0002913 4 0.082
regulation of leukocyte differentiation GO:1902105 159 0.081
Human
negative regulation of immune effector process GO:0002698 55 0.081
cytokine mediated signaling pathway GO:0019221 115 0.079
negative regulation of cellular amine metabolic process GO:0033239 1 0.079
regulation of epithelial cell proliferation GO:0050678 141 0.078
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.078
t cell receptor signaling pathway GO:0050852 46 0.078
Mouse
regulation of protein kinase activity GO:0045859 232 0.077
muscle tissue development GO:0060537 308 0.077
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.077
peptidyl tyrosine phosphorylation GO:0018108 143 0.076
regulation of t cell proliferation GO:0042129 92 0.076
Mouse
negative regulation of secretion GO:0051048 61 0.076
lymphocyte anergy GO:0002249 4 0.076
negative regulation of cell proliferation GO:0008285 296 0.075
Human
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.074
negative regulation of interleukin 2 production GO:0032703 8 0.073
second messenger mediated signaling GO:0019932 73 0.073
myeloid cell apoptotic process GO:0033028 22 0.073
negative regulation of eosinophil degranulation GO:0043310 1 0.072
leukocyte apoptotic process GO:0071887 71 0.071
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.071
Mouse
regulation of protein maturation GO:1903317 96 0.071
positive regulation of epithelial cell proliferation GO:0050679 68 0.070
regulation of b cell activation GO:0050864 81 0.070
Human Mouse
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.069
maintenance of location GO:0051235 89 0.069
cellular response to biotic stimulus GO:0071216 92 0.069
regulation of ion homeostasis GO:2000021 64 0.068
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.068
regulation of vasculature development GO:1901342 88 0.068
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.067
interleukin 2 mediated signaling pathway GO:0038110 2 0.067
negative regulation of molecular function GO:0044092 258 0.067
cytoplasmic transport GO:0016482 234 0.067
b cell chemotaxis GO:0035754 3 0.066
positive regulation of leukocyte mediated immunity GO:0002705 70 0.066
Mouse
mitotic cell cycle process GO:1903047 159 0.066
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.066
actin cytoskeleton organization GO:0030036 220 0.065
hematopoietic stem cell migration GO:0035701 1 0.065
cellular response to hormone stimulus GO:0032870 150 0.065
microglial cell activation involved in immune response GO:0002282 1 0.064
regulation of immunoglobulin mediated immune response GO:0002889 37 0.063
Mouse
t helper 1 type immune response GO:0042088 25 0.063
stem cell development GO:0048864 219 0.062
regulation of response to wounding GO:1903034 189 0.062
Mouse
neuron death GO:0070997 154 0.061
camera type eye development GO:0043010 266 0.061
regulation of proteolysis GO:0030162 164 0.061
cell fate commitment GO:0045165 210 0.061
peptidyl amino acid modification GO:0018193 336 0.061
endomembrane system organization GO:0010256 147 0.061
negative regulation of cellular component organization GO:0051129 194 0.060
multicellular organismal signaling GO:0035637 91 0.060
interleukin 10 secretion GO:0072608 4 0.059
positive regulation of b cell mediated immunity GO:0002714 26 0.059
Mouse
endocytosis GO:0006897 168 0.059
regulation of peptidase activity GO:0052547 96 0.058
positive regulation of interleukin 2 biosynthetic process GO:0045086 8 0.058
Mouse
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.057
positive regulation of t cell extravasation GO:2000409 2 0.057
extrinsic apoptotic signaling pathway GO:0097191 126 0.057
regulation of cell projection organization GO:0031344 206 0.056
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.056
Mouse
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.056
positive regulation of protein modification process GO:0031401 299 0.056
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.056
Mouse
positive regulation of lymphocyte differentiation GO:0045621 61 0.056
t cell selection GO:0045058 34 0.056
Mouse
t helper cell differentiation GO:0042093 28 0.055
negative t cell selection GO:0043383 13 0.055
Mouse
epithelial cell proliferation GO:0050673 174 0.055
regulation of monocyte extravasation GO:2000437 2 0.055
cellular response to lipid GO:0071396 145 0.055
cell activation involved in immune response GO:0002263 126 0.055
Mouse
eosinophil degranulation GO:0043308 1 0.055
t cell differentiation involved in immune response GO:0002292 30 0.055
regulation of immunological synapse formation GO:2000520 2 0.054
positive regulation of thymocyte migration GO:2000412 2 0.054
divalent inorganic cation homeostasis GO:0072507 138 0.054
regulation of transferase activity GO:0051338 263 0.054
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.054
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.053
dendritic cell chemotaxis GO:0002407 7 0.053
positive regulation of immunological synapse formation GO:2000522 1 0.053
cell chemotaxis GO:0060326 81 0.053
positive regulation of protein kinase b signaling GO:0051897 32 0.053
Mouse
cytokine metabolic process GO:0042107 71 0.052
Mouse
inflammatory response to antigenic stimulus GO:0002437 30 0.052
Mouse
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.052
negative regulation of growth GO:0045926 99 0.052
positive regulation of protein kinase activity GO:0045860 144 0.052
regulation of hypersensitivity GO:0002883 10 0.052
skeletal muscle organ development GO:0060538 163 0.051
protein kinase b signaling GO:0043491 74 0.051
Mouse
ensheathment of neurons GO:0007272 76 0.051
positive regulation of hydrolase activity GO:0051345 148 0.051
t helper 17 cell chemotaxis GO:0035705 1 0.050
regulation of angiotensin levels in blood GO:0002002 4 0.050
b cell mediated immunity GO:0019724 71 0.050
Mouse
response to growth factor GO:0070848 198 0.050
positive regulation of monocyte extravasation GO:2000439 1 0.050
alpha beta t cell activation involved in immune response GO:0002287 31 0.049
negative regulation of homeostatic process GO:0032845 71 0.049
eosinophil migration GO:0072677 3 0.049
positive regulation of cytokine secretion GO:0050715 41 0.049
regulation of t cell mediated immunity GO:0002709 34 0.049
stem cell differentiation GO:0048863 268 0.049
metal ion homeostasis GO:0055065 189 0.048
neuron migration GO:0001764 122 0.048
blood vessel morphogenesis GO:0048514 285 0.048
myeloid leukocyte mediated immunity GO:0002444 42 0.048
angiogenesis GO:0001525 201 0.047
cellular response to organonitrogen compound GO:0071417 145 0.047
myeloid leukocyte activation GO:0002274 83 0.047
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.047
axon ensheathment GO:0008366 76 0.047
skin development GO:0043588 220 0.047
cellular response to dna damage stimulus GO:0006974 207 0.047
Human
negative regulation of multi organism process GO:0043901 68 0.046
regulation of b cell proliferation GO:0030888 39 0.046
Human
t helper 2 cell cytokine production GO:0035745 4 0.046
urogenital system development GO:0001655 261 0.046
interleukin 8 secretion GO:0072606 3 0.046
axonogenesis GO:0007409 274 0.046
regulation of apoptotic signaling pathway GO:2001233 197 0.046
carbohydrate metabolic process GO:0005975 230 0.046
gland development GO:0048732 330 0.046
positive regulation of protein secretion GO:0050714 52 0.046
negative regulation of apoptotic signaling pathway GO:2001234 104 0.045
membrane organization GO:0061024 245 0.045
regulation of eosinophil degranulation GO:0043309 1 0.045
homeostasis of number of cells GO:0048872 210 0.045
t cell mediated immunity GO:0002456 50 0.045
neuronal action potential GO:0019228 54 0.044
cellular response to growth factor stimulus GO:0071363 197 0.044
ameboidal type cell migration GO:0001667 128 0.044
organic cyclic compound catabolic process GO:1901361 295 0.044
purine ribonucleoside metabolic process GO:0046128 241 0.044
regulation of organelle organization GO:0033043 289 0.044
interleukin 1 secretion GO:0050701 16 0.044
positive regulation of leukocyte differentiation GO:1902107 86 0.044
regulation of angiotensin metabolic process GO:0060177 4 0.043
glycoprotein metabolic process GO:0009100 116 0.043
forebrain development GO:0030900 302 0.043
negative regulation of lymphocyte activation GO:0051250 91 0.043
Human
negative regulation of leukocyte proliferation GO:0070664 46 0.043
Human
inflammatory cell apoptotic process GO:0006925 11 0.043
organonitrogen compound catabolic process GO:1901565 264 0.042
regulation of production of molecular mediator of immune response GO:0002700 65 0.042
Mouse
response to acid chemical GO:0001101 111 0.042
t helper 1 cell cytokine production GO:0035744 1 0.040
negative regulation of proteolysis GO:0045861 74 0.040
response to interferon gamma GO:0034341 34 0.040
regulation of interleukin 4 biosynthetic process GO:0045402 3 0.040
positive regulation of angiogenesis GO:0045766 46 0.040
plasma membrane organization GO:0007009 90 0.040
natural killer cell mediated immunity GO:0002228 29 0.040
regulation of neuron apoptotic process GO:0043523 122 0.040
positive regulation of t cell differentiation GO:0045582 52 0.040
regulation of cysteine type endopeptidase activity GO:2000116 65 0.039
dna metabolic process GO:0006259 303 0.039
Mouse
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.039
tumor necrosis factor production GO:0032640 50 0.039
positive regulation of muscle cell differentiation GO:0051149 39 0.039
fertilization GO:0009566 127 0.038
positive regulation of b cell chemotaxis GO:2000538 2 0.038
neuron apoptotic process GO:0051402 142 0.038
myeloid leukocyte migration GO:0097529 57 0.038
negative regulation of protein processing GO:0010955 79 0.038
regulation of t helper 1 type immune response GO:0002825 17 0.038
regulation of homeostatic process GO:0032844 182 0.038
positive regulation of response to wounding GO:1903036 66 0.037
Mouse
somatic cell dna recombination GO:0016444 51 0.037
Mouse
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.037
negative regulation of intracellular signal transduction GO:1902532 167 0.037
t helper 1 cell differentiation GO:0045063 13 0.037
sensory perception GO:0007600 245 0.037
purine nucleoside triphosphate catabolic process GO:0009146 203 0.037
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.036
response to interleukin 4 GO:0070670 23 0.036
positive regulation of mapk cascade GO:0043410 170 0.036
regulation of t helper 2 cell cytokine production GO:2000551 3 0.036
mitotic cell cycle GO:0000278 195 0.036
positive regulation of tumor necrosis factor production GO:0032760 30 0.036
rho protein signal transduction GO:0007266 32 0.036
nucleocytoplasmic transport GO:0006913 139 0.036
negative regulation of vasculature development GO:1901343 26 0.035
interleukin 4 production GO:0032633 24 0.035
humoral immune response GO:0006959 57 0.035
monocyte chemotaxis GO:0002548 5 0.035
positive regulation of eosinophil migration GO:2000418 2 0.035
stress activated protein kinase signaling cascade GO:0031098 81 0.035
protein localization to nucleus GO:0034504 121 0.034
type 2 immune response GO:0042092 23 0.034
cellular metal ion homeostasis GO:0006875 151 0.034
myoblast differentiation GO:0045445 52 0.034
antibacterial peptide production GO:0002778 2 0.034
nucleoside phosphate metabolic process GO:0006753 338 0.034
telencephalon development GO:0021537 186 0.034
cellular homeostasis GO:0019725 240 0.034
positive regulation of nucleotide metabolic process GO:0045981 114 0.034
small gtpase mediated signal transduction GO:0007264 97 0.034
regulation of cellular response to stress GO:0080135 159 0.034
regulation of cell cycle GO:0051726 281 0.034
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.034
Mouse
positive regulation of cell projection organization GO:0031346 95 0.034
developmental growth involved in morphogenesis GO:0060560 138 0.033
myotube differentiation GO:0014902 105 0.033
skeletal muscle fiber development GO:0048741 58 0.033
defense response to bacterium GO:0042742 119 0.033
monocyte extravasation GO:0035696 2 0.033
positive regulation of striated muscle cell differentiation GO:0051155 35 0.033
defense response to gram positive bacterium GO:0050830 50 0.033
action potential GO:0001508 78 0.033
regulation of cellular component biogenesis GO:0044087 181 0.033
positive regulation of behavior GO:0048520 40 0.033
nuclear transport GO:0051169 139 0.033
regulation of regulated secretory pathway GO:1903305 20 0.033
regulation of neuron death GO:1901214 134 0.033
cell recognition GO:0008037 83 0.032
lymphocyte activation involved in immune response GO:0002285 93 0.032
Mouse
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.032
Mouse
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.032
leukocyte degranulation GO:0043299 27 0.032
intracellular protein transport GO:0006886 204 0.032
exocytosis GO:0006887 121 0.032
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.032
regulation of exocytosis GO:0017157 61 0.032
nuclear division GO:0000280 158 0.032
cd4 positive alpha beta t cell activation GO:0035710 45 0.032
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.031
divalent inorganic cation transport GO:0072511 178 0.031
regulation of interleukin 8 production GO:0032677 3 0.031
interleukin 18 mediated signaling pathway GO:0035655 2 0.031
syncytium formation by plasma membrane fusion GO:0000768 42 0.031
somatic diversification of immunoglobulins GO:0016445 43 0.031
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.031
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.031
alpha beta t cell differentiation GO:0046632 69 0.031
purine containing compound metabolic process GO:0072521 311 0.031
thymic t cell selection GO:0045061 22 0.031
Mouse
cell cell recognition GO:0009988 44 0.031
protein catabolic process GO:0030163 221 0.031
signal transduction in absence of ligand GO:0038034 55 0.030
regulation of peptide transport GO:0090087 91 0.030
positive regulation of type 2 immune response GO:0002830 9 0.030
peptide transport GO:0015833 133 0.030
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.030
cellular response to molecule of bacterial origin GO:0071219 83 0.030
negative regulation of peptidase activity GO:0010466 46 0.030
organelle fission GO:0048285 170 0.030
notch signaling pathway GO:0007219 71 0.030
antimicrobial peptide production GO:0002775 2 0.030
response to interleukin 15 GO:0070672 3 0.030
positive regulation of immunoglobulin production GO:0002639 28 0.029
Mouse
nucleoside metabolic process GO:0009116 246 0.029
cell division GO:0051301 120 0.029
astrocyte cell migration GO:0043615 3 0.029
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.029
cellular calcium ion homeostasis GO:0006874 119 0.029
regulation of interleukin 8 secretion GO:2000482 2 0.029
positive regulation of transferase activity GO:0051347 167 0.029
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.029
regulation of cellular catabolic process GO:0031329 242 0.029
negative regulation of adaptive immune response GO:0002820 25 0.029
positive regulation of cell migration GO:0030335 109 0.029
purine ribonucleoside catabolic process GO:0046130 205 0.028
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.028
response to peptide GO:1901652 136 0.028
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.028
morphogenesis of a branching structure GO:0001763 203 0.028
regulation of leukocyte apoptotic process GO:2000106 56 0.028
regulation of hematopoietic stem cell migration GO:2000471 1 0.028
positive regulation of cell development GO:0010720 237 0.028
regulation of tumor necrosis factor production GO:0032680 49 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.028
positive regulation of endothelial cell proliferation GO:0001938 17 0.027
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.027
immune complex clearance by monocytes and macrophages GO:0002436 2 0.027
immune response inhibiting signal transduction GO:0002765 4 0.027
positive regulation of cytoplasmic transport GO:1903651 40 0.027
developmental maturation GO:0021700 193 0.027
isotype switching to igg isotypes GO:0048291 10 0.027
Mouse
cation homeostasis GO:0055080 212 0.027
mammary gland morphogenesis GO:0060443 54 0.027
nucleotide catabolic process GO:0009166 217 0.027
positive regulation of kinase activity GO:0033674 155 0.027
tolerance induction GO:0002507 14 0.027
muscle fiber development GO:0048747 76 0.027
cellular nitrogen compound catabolic process GO:0044270 280 0.027
regulation of striated muscle cell differentiation GO:0051153 81 0.026
muscle cell differentiation GO:0042692 261 0.026
ribose phosphate metabolic process GO:0019693 291 0.026
positive regulation of nervous system development GO:0051962 221 0.026
cytosolic calcium ion transport GO:0060401 48 0.026
negative regulation of interferon gamma production GO:0032689 18 0.026
response to organonitrogen compound GO:0010243 246 0.026
negative regulation of cell cycle GO:0045786 123 0.026
nucleoside triphosphate catabolic process GO:0009143 205 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.026
negative regulation of t cell proliferation GO:0042130 38 0.026
regulation of myotube differentiation GO:0010830 62 0.026
regulation of vascular endothelial growth factor production GO:0010574 13 0.026
negative regulation of leukocyte apoptotic process GO:2000107 31 0.026
regulation of acute inflammatory response GO:0002673 27 0.026
regulation of ion transport GO:0043269 215 0.026
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.026
Mouse
single organismal cell cell adhesion GO:0016337 131 0.026
mapk cascade GO:0000165 281 0.026
protein localization to organelle GO:0033365 185 0.026
detection of stimulus GO:0051606 84 0.025
positive regulation of apoptotic signaling pathway GO:2001235 95 0.025
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.025
leukocyte homeostasis GO:0001776 79 0.025

Ctla4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.065
Human
disease of anatomical entity DOID:7 0 0.065
Human
cancer DOID:162 0 0.028
disease of cellular proliferation DOID:14566 0 0.028
organ system cancer DOID:0050686 0 0.028