Mus musculus

49 known processes

Cul1

cullin 1

Cul1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 207 0.909
modification dependent macromolecule catabolic process GO:0043632 133 0.536
cellular protein catabolic process GO:0044257 155 0.415
regulation of protein stability GO:0031647 52 0.397
protein modification by small protein conjugation GO:0032446 187 0.285
proteasomal protein catabolic process GO:0010498 98 0.261
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.248
mitotic cell cycle process GO:1903047 159 0.226
Worm Fly
cellular macromolecule catabolic process GO:0044265 206 0.223
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.215
response to light stimulus GO:0009416 135 0.195
cellular response to dna damage stimulus GO:0006974 207 0.192
Fly
stem cell development GO:0048864 219 0.164
ribonucleoside triphosphate catabolic process GO:0009203 199 0.126
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.125
myosin filament organization GO:0031033 3 0.124
positive regulation of protein complex assembly GO:0031334 45 0.118
ubiquitin dependent protein catabolic process GO:0006511 129 0.115
nucleotide metabolic process GO:0009117 332 0.109
nucleoside triphosphate catabolic process GO:0009143 205 0.101
ribonucleoside catabolic process GO:0042454 206 0.101
protein localization to organelle GO:0033365 185 0.098
dna metabolic process GO:0006259 303 0.097
guanosine containing compound metabolic process GO:1901068 144 0.094
purine ribonucleotide metabolic process GO:0009150 290 0.094
cell division GO:0051301 120 0.089
myosin filament assembly GO:0031034 2 0.089
establishment of protein localization to organelle GO:0072594 118 0.089
nucleoside catabolic process GO:0009164 206 0.089
carbohydrate derivative catabolic process GO:1901136 231 0.089
purine nucleoside triphosphate metabolic process GO:0009144 226 0.087
protein targeting GO:0006605 143 0.085
membrane organization GO:0061024 245 0.083
glycosyl compound catabolic process GO:1901658 206 0.082
regulation of protein localization GO:0032880 231 0.080
nucleoside phosphate metabolic process GO:0006753 338 0.078
striated muscle myosin thick filament assembly GO:0071688 1 0.077
cytoplasmic transport GO:0016482 234 0.077
nucleoside metabolic process GO:0009116 246 0.075
cellular ketone metabolic process GO:0042180 84 0.072
purine ribonucleoside catabolic process GO:0046130 205 0.068
protein import GO:0017038 101 0.067
negative regulation of protein metabolic process GO:0051248 282 0.067
nucleoside triphosphate metabolic process GO:0009141 230 0.059
macromolecule catabolic process GO:0009057 281 0.058
cellular nitrogen compound catabolic process GO:0044270 280 0.058
organelle assembly GO:0070925 177 0.057
peptidyl amino acid modification GO:0018193 336 0.055
nucleoside phosphate catabolic process GO:1901292 222 0.053
heterocycle catabolic process GO:0046700 280 0.052
negative regulation of dna replication GO:0008156 4 0.052
ribonucleotide metabolic process GO:0009259 291 0.051
protein ubiquitination GO:0016567 171 0.051
protein catabolic process GO:0030163 221 0.049
ribose phosphate metabolic process GO:0019693 291 0.048
apoptotic signaling pathway GO:0097190 306 0.048
small gtpase mediated signal transduction GO:0007264 97 0.047
mitotic cell cycle GO:0000278 195 0.046
Worm Fly
positive regulation of cellular catabolic process GO:0031331 148 0.046
regulation of ras gtpase activity GO:0032318 88 0.045
cellular amino acid metabolic process GO:0006520 103 0.045
intracellular protein transport GO:0006886 204 0.043
posttranscriptional regulation of gene expression GO:0010608 155 0.042
purine ribonucleotide catabolic process GO:0009154 208 0.042
organonitrogen compound catabolic process GO:1901565 264 0.041
regulation of cellular amino acid metabolic process GO:0006521 5 0.041
stem cell differentiation GO:0048863 268 0.040
regulation of kinase activity GO:0043549 249 0.040
organophosphate catabolic process GO:0046434 232 0.040
purine nucleoside metabolic process GO:0042278 241 0.039
scf dependent proteasomal ubiquitin dependent protein catabolic process GO:0031146 10 0.039
regulation of protein complex assembly GO:0043254 83 0.038
positive regulation of hydrolase activity GO:0051345 148 0.038
aromatic compound catabolic process GO:0019439 286 0.038
purine nucleoside catabolic process GO:0006152 205 0.038
ras protein signal transduction GO:0007265 77 0.037
regulation of organelle organization GO:0033043 289 0.037
regulation of transcription factor import into nucleus GO:0042990 24 0.036
gonad development GO:0008406 141 0.036
Worm
purine nucleotide catabolic process GO:0006195 211 0.036
rna splicing GO:0008380 54 0.035
positive regulation of proteolysis GO:0045862 85 0.035
gtp metabolic process GO:0046039 144 0.035
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.034
ribonucleoside triphosphate metabolic process GO:0009199 220 0.034
positive regulation of nucleotide catabolic process GO:0030813 88 0.034
rna processing GO:0006396 105 0.034
actomyosin structure organization GO:0031032 56 0.034
purine nucleoside triphosphate catabolic process GO:0009146 203 0.034
muscle cell differentiation GO:0042692 261 0.033
regulation of hydrolase activity GO:0051336 246 0.033
cell fate commitment GO:0045165 210 0.032
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.032
blood vessel morphogenesis GO:0048514 285 0.032
purine nucleotide metabolic process GO:0006163 302 0.032
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.031
male gamete generation GO:0048232 285 0.031
ribonucleotide catabolic process GO:0009261 208 0.031
regulation of protein catabolic process GO:0042176 108 0.031
covalent chromatin modification GO:0016569 163 0.030
cell adhesion GO:0007155 329 0.030
regulation of cell motility GO:2000145 236 0.030
regulation of purine nucleotide catabolic process GO:0033121 122 0.029
actin cytoskeleton organization GO:0030036 220 0.029
nuclear import GO:0051170 95 0.029
regulation of response to dna damage stimulus GO:2001020 34 0.029
purine containing compound catabolic process GO:0072523 213 0.029
modification dependent protein catabolic process GO:0019941 133 0.029
organelle fission GO:0048285 170 0.028
Worm
regulation of cellular ketone metabolic process GO:0010565 66 0.028
purine containing compound metabolic process GO:0072521 311 0.028
protein modification by small protein removal GO:0070646 21 0.028
peptidyl serine phosphorylation GO:0018105 74 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.027
nucleotide catabolic process GO:0009166 217 0.026
microtubule based process GO:0007017 236 0.026
synaptic transmission GO:0007268 329 0.026
single organism nuclear import GO:1902593 95 0.026
regulation of protein targeting GO:1903533 61 0.026
organic cyclic compound catabolic process GO:1901361 295 0.026
negative regulation of cell proliferation GO:0008285 296 0.025
Worm
cellular protein complex assembly GO:0043623 116 0.025
ribonucleoside metabolic process GO:0009119 245 0.025
dna repair GO:0006281 107 0.024
regulation of cell cycle GO:0051726 281 0.024
Worm Fly
purine ribonucleoside metabolic process GO:0046128 241 0.023
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.023
transmembrane transport GO:0055085 412 0.023
establishment of organelle localization GO:0051656 122 0.023
regulation of cellular component biogenesis GO:0044087 181 0.023
establishment or maintenance of cell polarity GO:0007163 86 0.023
positive regulation of cell death GO:0010942 224 0.023
Worm
germ cell development GO:0007281 185 0.022
nucleobase containing small molecule metabolic process GO:0055086 352 0.022
response to radiation GO:0009314 165 0.022
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.022
Fly
regulation of transmembrane transport GO:0034762 128 0.022
cellular component assembly involved in morphogenesis GO:0010927 139 0.022
methylation GO:0032259 134 0.022
regulation of transferase activity GO:0051338 263 0.022
regulation of nucleotide metabolic process GO:0006140 169 0.022
dna endoreduplication GO:0042023 4 0.021
skeletal muscle cell differentiation GO:0035914 66 0.021
positive regulation of nucleoside metabolic process GO:0045979 91 0.021
endomembrane system organization GO:0010256 147 0.021
cytokinesis GO:0000910 17 0.021
epithelial tube morphogenesis GO:0060562 303 0.021
negative regulation of cellular protein metabolic process GO:0032269 247 0.020
regulation of cell migration GO:0030334 219 0.020
protein import into nucleus GO:0006606 95 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.020
muscle tissue development GO:0060537 308 0.020
negative regulation of triglyceride biosynthetic process GO:0010868 2 0.020
negative regulation of cell cycle GO:0045786 123 0.019
Worm Fly
positive regulation of protein phosphorylation GO:0001934 242 0.019
regulation of nucleotide catabolic process GO:0030811 122 0.019
cellular amine metabolic process GO:0044106 44 0.019
positive regulation of protein modification process GO:0031401 299 0.018
guanosine containing compound catabolic process GO:1901069 144 0.018
nucleocytoplasmic transport GO:0006913 139 0.018
mesenchymal cell differentiation GO:0048762 107 0.018
regulation of cellular response to growth factor stimulus GO:0090287 82 0.018
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.018
lipid localization GO:0010876 126 0.018
organelle localization GO:0051640 179 0.018
protein sumoylation GO:0016925 14 0.018
endocytosis GO:0006897 168 0.018
Worm
epithelial cell proliferation GO:0050673 174 0.017
amine metabolic process GO:0009308 45 0.017
regulation of cellular catabolic process GO:0031329 242 0.017
wound healing GO:0042060 157 0.017
stem cell maintenance GO:0019827 130 0.017
regulation of mitotic cell cycle GO:0007346 126 0.017
Worm Fly
positive regulation of ras gtpase activity GO:0032320 65 0.017
regulation of histone modification GO:0031056 56 0.016
placenta development GO:0001890 140 0.016
snrna metabolic process GO:0016073 1 0.016
adult behavior GO:0030534 135 0.016
protein stabilization GO:0050821 25 0.016
regulation of proteasomal protein catabolic process GO:0061136 46 0.016
regulation of epithelial cell proliferation GO:0050678 141 0.016
response to transforming growth factor beta GO:0071559 88 0.016
protein localization to membrane GO:0072657 108 0.016
regulation of mapk cascade GO:0043408 248 0.016
stem cell division GO:0017145 30 0.015
mesenchyme development GO:0060485 152 0.015
muscle cell development GO:0055001 133 0.015
mesenchymal cell development GO:0014031 93 0.015
rna splicing via transesterification reactions GO:0000375 43 0.015
negative regulation of cellular catabolic process GO:0031330 47 0.015
regulation of cellular protein catabolic process GO:1903362 61 0.015
regulation of ion transmembrane transport GO:0034765 119 0.015
body morphogenesis GO:0010171 45 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.015
chemotaxis GO:0006935 247 0.015
actin mediated cell contraction GO:0070252 15 0.015
regulation of protein processing GO:0070613 96 0.014
positive regulation of cellular component biogenesis GO:0044089 94 0.014
response to uv GO:0009411 44 0.014
striated muscle cell development GO:0055002 125 0.014
renal system development GO:0072001 225 0.014
lateral inhibition GO:0046331 1 0.014
atp metabolic process GO:0046034 75 0.014
positive regulation of nucleotide metabolic process GO:0045981 114 0.014
cellular response to peptide hormone stimulus GO:0071375 92 0.014
Fly
regulation of cytoplasmic transport GO:1903649 112 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
gene silencing GO:0016458 38 0.014
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.014
spermatogenesis GO:0007283 284 0.014
spermatid differentiation GO:0048515 115 0.013
metaphase plate congression GO:0051310 2 0.013
gland development GO:0048732 330 0.013
negative regulation of protein maturation GO:1903318 79 0.013
mitotic nuclear division GO:0007067 48 0.013
Worm
sperm motility GO:0030317 47 0.013
regulation of protein localization to nucleus GO:1900180 60 0.013
regulation of cellular component size GO:0032535 121 0.013
Worm
dna replication GO:0006260 52 0.013
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.013
locomotory behavior GO:0007626 195 0.013
regulation of proteolysis GO:0030162 164 0.013
positive regulation of transcription by galactose GO:0000411 1 0.013
hematopoietic progenitor cell differentiation GO:0002244 143 0.013
axonogenesis GO:0007409 274 0.013
positive regulation of transferase activity GO:0051347 167 0.013
negative regulation of cell development GO:0010721 169 0.013
response to growth factor GO:0070848 198 0.012
regulation of cell cycle process GO:0010564 160 0.012
Fly
regulation of intracellular protein transport GO:0033157 82 0.012
rho protein signal transduction GO:0007266 32 0.012
t cell activation GO:0042110 289 0.012
regulation of nucleocytoplasmic transport GO:0046822 73 0.012
cell type specific apoptotic process GO:0097285 268 0.012
neuron projection guidance GO:0097485 141 0.012
nuclear transport GO:0051169 139 0.012
cell cycle checkpoint GO:0000075 47 0.012
Fly
cell growth GO:0016049 130 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
positive regulation of gtp catabolic process GO:0033126 85 0.012
digestive system development GO:0055123 200 0.012
negative regulation of mitotic cell cycle GO:0045930 58 0.012
Worm Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.012
intracellular receptor signaling pathway GO:0030522 74 0.012
epithelial to mesenchymal transition GO:0001837 47 0.012
dna recombination GO:0006310 92 0.012
response to organic cyclic compound GO:0014070 198 0.011
reproductive behavior GO:0019098 32 0.011
positive regulation of protein catabolic process GO:0045732 60 0.011
mrna metabolic process GO:0016071 84 0.011
blastocyst formation GO:0001825 33 0.011
peptidyl serine modification GO:0018209 83 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
regulation of cellular response to stress GO:0080135 159 0.011
gastrulation GO:0007369 116 0.011
oocyte construction GO:0007308 2 0.011
maternal determination of anterior posterior axis embryo GO:0008358 2 0.011
regulation of mitosis GO:0007088 29 0.011
purine nucleoside monophosphate catabolic process GO:0009128 58 0.011
regulation of protein kinase activity GO:0045859 232 0.011
b cell activation GO:0042113 161 0.011
regulation of cellular amine metabolic process GO:0033238 20 0.011
protein localization to nucleus GO:0034504 121 0.011
regulation of binding GO:0051098 111 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
mitotic cytokinesis GO:0000281 4 0.011
oocyte anterior posterior axis specification GO:0007314 2 0.011
ion transmembrane transport GO:0034220 361 0.011
synapse organization GO:0050808 125 0.010
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
molting cycle GO:0042303 90 0.010
genitalia development GO:0048806 37 0.010
negative regulation of intracellular signal transduction GO:1902532 167 0.010
Fly
androgen receptor signaling pathway GO:0030521 8 0.010
stem cell proliferation GO:0072089 117 0.010
calcium ion transmembrane transport GO:0070588 85 0.010

Cul1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 0 0.085
disease of anatomical entity DOID:7 0 0.085
muscular disease DOID:0080000 0 0.085
muscle tissue disease DOID:66 0 0.064
myopathy DOID:423 0 0.064
physical disorder DOID:0080015 0 0.043
nervous system disease DOID:863 0 0.019
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
muscular dystrophy DOID:9884 0 0.016
eye disease DOID:5614 0 0.014