Mus musculus

73 known processes

Cul3

cullin 3

(Aliases: mKIAA0617,AI467304,AW146203)

Cul3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.951
cellular protein catabolic process GO:0044257 155 0.796
modification dependent macromolecule catabolic process GO:0043632 133 0.734
cellular macromolecule catabolic process GO:0044265 206 0.702
proteasomal protein catabolic process GO:0010498 98 0.627
protein catabolic process GO:0030163 221 0.551
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.476
cellular response to dna damage stimulus GO:0006974 207 0.379
establishment of protein localization to organelle GO:0072594 118 0.369
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.339
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.338
germ cell development GO:0007281 185 0.336
circadian rhythm GO:0007623 114 0.334
spermatid differentiation GO:0048515 115 0.300
regionalization GO:0003002 337 0.293
cellular response to growth factor stimulus GO:0071363 197 0.292
macromolecule catabolic process GO:0009057 281 0.290
cellular response to cytokine stimulus GO:0071345 189 0.264
protein modification by small protein conjugation or removal GO:0070647 207 0.261
Human
stem cell differentiation GO:0048863 268 0.256
regulation of translation GO:0006417 71 0.228
pole plasm assembly GO:0007315 2 0.225
negative regulation of protein metabolic process GO:0051248 282 0.224
protein localization to organelle GO:0033365 185 0.222
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 2 0.221
regulation of protein import into nucleus GO:0042306 52 0.221
regulation of cytoplasmic transport GO:1903649 112 0.219
oocyte anterior posterior axis specification GO:0007314 2 0.218
modification dependent protein catabolic process GO:0019941 133 0.187
translation GO:0006412 93 0.184
regulation of cellular response to stress GO:0080135 159 0.180
ubiquitin dependent protein catabolic process GO:0006511 129 0.173
intracellular protein transport GO:0006886 204 0.172
protein modification by small protein conjugation GO:0032446 187 0.169
Human
regulation of transcription factor import into nucleus GO:0042990 24 0.159
compound eye development GO:0048749 1 0.156
regulation of apoptotic signaling pathway GO:2001233 197 0.155
rhythmic process GO:0048511 174 0.154
protein modification by small protein removal GO:0070646 21 0.146
mesenchyme development GO:0060485 152 0.141
positive regulation of nfat protein import into nucleus GO:0051533 1 0.132
response to transforming growth factor beta GO:0071559 88 0.132
regulation of intracellular transport GO:0032386 159 0.129
regulation of mitotic cell cycle GO:0007346 126 0.128
Human
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.122
cellular response to insulin stimulus GO:0032869 78 0.115
developmental maturation GO:0021700 193 0.114
organelle fission GO:0048285 170 0.113
Human
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.112
regulation of response to dna damage stimulus GO:2001020 34 0.112
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.111
negative regulation of cellular protein metabolic process GO:0032269 247 0.111
cellular amine metabolic process GO:0044106 44 0.109
positive regulation of intracellular transport GO:0032388 70 0.104
spermatid development GO:0007286 108 0.103
posttranscriptional regulation of gene expression GO:0010608 155 0.098
mitotic cell cycle GO:0000278 195 0.096
Human
stem cell development GO:0048864 219 0.094
intracellular mrna localization GO:0008298 4 0.091
ribonucleoside monophosphate metabolic process GO:0009161 80 0.091
nitrogen compound transport GO:0071705 271 0.088
regulation of intracellular protein transport GO:0033157 82 0.087
positive regulation of cellular catabolic process GO:0031331 148 0.086
Human
jnk cascade GO:0007254 72 0.086
spermatogenesis GO:0007283 284 0.086
nuclear division GO:0000280 158 0.086
Human
nucleobase containing small molecule metabolic process GO:0055086 352 0.086
nucleotide metabolic process GO:0009117 332 0.085
maternal determination of anterior posterior axis embryo GO:0008358 2 0.081
purine containing compound metabolic process GO:0072521 311 0.080
dna repair GO:0006281 107 0.079
oocyte development GO:0048599 33 0.079
protein import GO:0017038 101 0.078
synapse organization GO:0050808 125 0.078
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.076
axonogenesis GO:0007409 274 0.074
mitochondrion transport along microtubule GO:0047497 3 0.072
response to osmotic stress GO:0006970 21 0.072
cytoplasmic transport GO:0016482 234 0.071
Human
protein targeting GO:0006605 143 0.070
membrane organization GO:0061024 245 0.069
Human
locomotory behavior GO:0007626 195 0.068
nuclear import GO:0051170 95 0.067
ossification GO:0001503 216 0.067
regulation of nucleocytoplasmic transport GO:0046822 73 0.067
ras protein signal transduction GO:0007265 77 0.066
Human
lipid localization GO:0010876 126 0.065
carbohydrate derivative biosynthetic process GO:1901137 183 0.065
meiotic cell cycle process GO:1903046 77 0.065
oocyte axis specification GO:0007309 2 0.065
gtp metabolic process GO:0046039 144 0.064
dendrite development GO:0016358 115 0.064
protein ubiquitination GO:0016567 171 0.063
Human
regulation of establishment of protein localization GO:0070201 181 0.063
homeostasis of number of cells GO:0048872 210 0.061
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.060
regulation of jnk cascade GO:0046328 62 0.060
adult behavior GO:0030534 135 0.058
regulation of protein catabolic process GO:0042176 108 0.058
Human
nucleocytoplasmic transport GO:0006913 139 0.057
mitotic cell cycle process GO:1903047 159 0.057
Human
single organism nuclear import GO:1902593 95 0.055
regulation of mrna processing GO:0050684 41 0.054
cerebellum development GO:0021549 77 0.053
negative regulation of phosphorylation GO:0042326 166 0.052
regulation of cellular component biogenesis GO:0044087 181 0.052
protein polyubiquitination GO:0000209 33 0.051
Human
intrinsic apoptotic signaling pathway GO:0097193 132 0.051
muscle cell differentiation GO:0042692 261 0.050
golgi localization GO:0051645 4 0.050
response to growth factor GO:0070848 198 0.050
leukocyte aggregation GO:0070486 1 0.050
oocyte construction GO:0007308 2 0.049
cell division GO:0051301 120 0.049
regulation of transferase activity GO:0051338 263 0.048
meiotic cell cycle GO:0051321 122 0.048
regulation of organelle organization GO:0033043 289 0.048
Human
polyamine biosynthetic process GO:0006596 2 0.048
nucleoside metabolic process GO:0009116 246 0.047
ribonucleoside metabolic process GO:0009119 245 0.047
cellularization GO:0007349 1 0.046
regulation of protein transport GO:0051223 163 0.046
nucleoside triphosphate catabolic process GO:0009143 205 0.046
chromatin organization GO:0006325 206 0.046
purine ribonucleotide catabolic process GO:0009154 208 0.045
regulation of androgen receptor signaling pathway GO:0060765 3 0.045
multicellular organismal aging GO:0010259 24 0.044
Worm
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.043
Human
innate immune response GO:0045087 157 0.043
positive regulation of dna templated transcription elongation GO:0032786 2 0.042
positive regulation of protein localization to nucleus GO:1900182 30 0.042
mapk cascade GO:0000165 281 0.042
purine ribonucleoside metabolic process GO:0046128 241 0.042
striated muscle tissue development GO:0014706 293 0.042
female gamete generation GO:0007292 74 0.041
regulation of cellular protein catabolic process GO:1903362 61 0.041
Human
synaptic growth at neuromuscular junction GO:0051124 6 0.041
purine nucleotide metabolic process GO:0006163 302 0.040
negative regulation of cell proliferation GO:0008285 296 0.039
positive regulation of cellular protein catabolic process GO:1903364 34 0.038
Human
endomembrane system organization GO:0010256 147 0.038
stress activated mapk cascade GO:0051403 80 0.037
oocyte differentiation GO:0009994 35 0.037
positive regulation of muscle adaptation GO:0014744 2 0.036
skeletal muscle organ development GO:0060538 163 0.036
nucleoside catabolic process GO:0009164 206 0.036
establishment of organelle localization GO:0051656 122 0.036
Human Worm
protein localization to nucleus GO:0034504 121 0.035
cellular ketone metabolic process GO:0042180 84 0.035
regulation of protein localization GO:0032880 231 0.034
nucleoside phosphate metabolic process GO:0006753 338 0.034
protein deubiquitination GO:0016579 19 0.034
intracellular receptor signaling pathway GO:0030522 74 0.034
purine nucleoside metabolic process GO:0042278 241 0.033
amide transport GO:0042886 138 0.033
maternal process involved in female pregnancy GO:0060135 32 0.032
regulation of protein targeting GO:1903533 61 0.032
regulation of cellular catabolic process GO:0031329 242 0.032
Human
cellular response to organonitrogen compound GO:0071417 145 0.032
centrosome duplication GO:0051298 16 0.032
regulation of defense response GO:0031347 233 0.032
male gamete generation GO:0048232 285 0.032
negative regulation of epithelial cell proliferation GO:0050680 64 0.031
adult locomotory behavior GO:0008344 91 0.031
lateral inhibition GO:0046331 1 0.031
regulation of protein localization to nucleus GO:1900180 60 0.031
nucleoside phosphate catabolic process GO:1901292 222 0.031
organelle localization GO:0051640 179 0.030
Human Worm
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.030
synaptic transmission GO:0007268 329 0.030
centrosome organization GO:0051297 26 0.030
positive regulation of protein phosphorylation GO:0001934 242 0.029
cell maturation GO:0048469 127 0.029
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.029
regulation of kinase activity GO:0043549 249 0.029
forebrain development GO:0030900 302 0.029
negative regulation of immune system process GO:0002683 209 0.028
negative regulation of phosphorus metabolic process GO:0010563 184 0.028
cellular amino acid metabolic process GO:0006520 103 0.028
dna integrity checkpoint GO:0031570 28 0.028
regulation of cell cycle process GO:0010564 160 0.028
Human
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.028
dephosphorylation GO:0016311 129 0.028
covalent chromatin modification GO:0016569 163 0.028
rna processing GO:0006396 105 0.027
organonitrogen compound catabolic process GO:1901565 264 0.027
purine ribonucleoside catabolic process GO:0046130 205 0.027
nuclear transport GO:0051169 139 0.027
ameboidal type cell migration GO:0001667 128 0.027
negative regulation of mitotic cell cycle GO:0045930 58 0.027
neuron projection extension GO:1990138 64 0.027
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.027
Human
spinal cord oligodendrocyte cell differentiation GO:0021529 3 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
metencephalon development GO:0022037 89 0.025
cellular response to arsenic containing substance GO:0071243 4 0.025
synapsis GO:0007129 34 0.025
negative regulation of protein modification process GO:0031400 163 0.025
centrosome separation GO:0051299 4 0.025
protein import into nucleus GO:0006606 95 0.024
ribonucleoside catabolic process GO:0042454 206 0.024
memory GO:0007613 58 0.024
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.024
purine nucleoside triphosphate catabolic process GO:0009146 203 0.024
peptide transport GO:0015833 133 0.024
apoptotic signaling pathway GO:0097190 306 0.023
endoplasmic reticulum tubular network organization GO:0071786 1 0.023
negative regulation of protein phosphorylation GO:0001933 126 0.023
cell growth GO:0016049 130 0.023
skeletal muscle cell differentiation GO:0035914 66 0.023
purine nucleotide catabolic process GO:0006195 211 0.023
regulation of proteolysis GO:0030162 164 0.023
Human
female sex differentiation GO:0046660 84 0.022
ribonucleoside triphosphate metabolic process GO:0009199 220 0.022
neural tube development GO:0021915 160 0.022
nucleus organization GO:0006997 45 0.022
regulation of cell projection organization GO:0031344 206 0.022
regulation of system process GO:0044057 200 0.022
positive regulation of proteolysis GO:0045862 85 0.022
Human
mesenchymal cell differentiation GO:0048762 107 0.022
guanosine containing compound metabolic process GO:1901068 144 0.022
microtubule organizing center organization GO:0031023 28 0.022
regulation of chromatin organization GO:1902275 57 0.021
n terminal protein amino acid modification GO:0031365 6 0.021
neural precursor cell proliferation GO:0061351 121 0.021
regulation of protein complex assembly GO:0043254 83 0.021
gtp catabolic process GO:0006184 143 0.021
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 3 0.021
myotube differentiation GO:0014902 105 0.021
alternative mrna splicing via spliceosome GO:0000380 12 0.021
segmentation GO:0035282 93 0.021
maintenance of location GO:0051235 89 0.021
establishment of vesicle localization GO:0051650 81 0.021
Human
positive regulation of response to dna damage stimulus GO:2001022 14 0.021
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.021
Human
purine containing compound catabolic process GO:0072523 213 0.021
circulatory system process GO:0003013 197 0.021
muscle tissue development GO:0060537 308 0.021
glucose homeostasis GO:0042593 128 0.021
mitotic nuclear division GO:0007067 48 0.020
Human
positive regulation of protein import into nucleus GO:0042307 26 0.020
mesenchymal cell development GO:0014031 93 0.020
transcription factor import into nucleus GO:0042991 26 0.020
amine metabolic process GO:0009308 45 0.020
positive regulation of cell cycle GO:0045787 92 0.020
Human
stress activated protein kinase signaling cascade GO:0031098 81 0.019
negative regulation of translation GO:0017148 22 0.019
mesodermal cell migration GO:0008078 4 0.019
determination of adult lifespan GO:0008340 11 0.019
Worm
carbohydrate derivative catabolic process GO:1901136 231 0.019
regulation of chromosome organization GO:0033044 83 0.019
Human
mitochondrion distribution GO:0048311 4 0.019
establishment of protein localization to endoplasmic reticulum GO:0072599 2 0.019
hyperosmotic response GO:0006972 4 0.019
regulation of stress activated mapk cascade GO:0032872 69 0.019
cellular chemical homeostasis GO:0055082 215 0.019
nucleotide catabolic process GO:0009166 217 0.019
regulation of membrane potential GO:0042391 192 0.019
stem cell maintenance GO:0019827 130 0.019
establishment of mitochondrion localization GO:0051654 4 0.019
regulation of cellular ketone metabolic process GO:0010565 66 0.019
regulation of cellular component size GO:0032535 121 0.018
heterocycle catabolic process GO:0046700 280 0.018
positive regulation of ran gtpase activity GO:0032853 3 0.018
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.018
cellular response to hormone stimulus GO:0032870 150 0.018
positive regulation of organelle organization GO:0010638 128 0.018
Human
purine nucleoside triphosphate metabolic process GO:0009144 226 0.018
cellular homeostasis GO:0019725 240 0.018
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.017
establishment of meiotic spindle orientation GO:0051296 1 0.017
purine ribonucleotide metabolic process GO:0009150 290 0.017
morphogenesis of embryonic epithelium GO:0016331 159 0.017
positive regulation of protein kinase activity GO:0045860 144 0.017
regulation of mitotic cell cycle phase transition GO:1901990 73 0.017
Human
cellular response to carbohydrate stimulus GO:0071322 50 0.017
positive regulation of ubiquitin protein transferase activity GO:0051443 4 0.017
multi multicellular organism process GO:0044706 109 0.017
rna splicing GO:0008380 54 0.017
regulation of epithelial cell proliferation GO:0050678 141 0.017
epithelial cell migration GO:0010631 63 0.017
male meiosis i GO:0007141 16 0.017
fertilization GO:0009566 127 0.016
Worm
defense response to gram negative bacterium GO:0050829 28 0.016
regulation of ion transport GO:0043269 215 0.016
connective tissue development GO:0061448 179 0.016
chromatin modification GO:0016568 187 0.016
response to oxidative stress GO:0006979 123 0.016
histone modification GO:0016570 159 0.016
rna localization GO:0006403 23 0.016
response to organonitrogen compound GO:0010243 246 0.016
regulation of secretion GO:0051046 274 0.016
ribose phosphate metabolic process GO:0019693 291 0.016
body morphogenesis GO:0010171 45 0.016
neuron migration GO:0001764 122 0.016
regulation of neuron differentiation GO:0045664 281 0.016
guanosine containing compound catabolic process GO:1901069 144 0.016
response to nutrient levels GO:0031667 109 0.016
nucleus localization GO:0051647 20 0.016
Worm
epithelium migration GO:0090132 63 0.016
pallium development GO:0021543 120 0.016
microtubule nucleation GO:0007020 2 0.016
regulation of cell migration GO:0030334 219 0.016
negative regulation of cell growth GO:0030308 44 0.015
rna splicing via transesterification reactions GO:0000375 43 0.015
ribonucleoprotein complex subunit organization GO:0071826 28 0.015
cellular nitrogen compound catabolic process GO:0044270 280 0.015
leukocyte mediated cytotoxicity GO:0001909 62 0.015
learning or memory GO:0007611 148 0.015
regulation of synapse assembly GO:0051963 29 0.015
nfat protein import into nucleus GO:0051531 6 0.015
positive regulation of transferase activity GO:0051347 167 0.015
meiotic nuclear division GO:0007126 115 0.015
protein autophosphorylation GO:0046777 61 0.015
cellular glucose homeostasis GO:0001678 52 0.015
regulation of ossification GO:0030278 112 0.014
oogenesis GO:0048477 56 0.014
cellular response to monosaccharide stimulus GO:0071326 47 0.014
cation transport GO:0006812 399 0.014
urogenital system development GO:0001655 261 0.014
cellular response to peptide hormone stimulus GO:0071375 92 0.014
response to radiation GO:0009314 165 0.014
organophosphate catabolic process GO:0046434 232 0.014
glycosyl compound metabolic process GO:1901657 246 0.014
regulation of ion transmembrane transport GO:0034765 119 0.014
axon guidance GO:0007411 141 0.014
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 26 0.014
neuron projection guidance GO:0097485 141 0.014
negative regulation of mapk cascade GO:0043409 65 0.014
defense response to other organism GO:0098542 197 0.013
mrna metabolic process GO:0016071 84 0.013
cellular response to prostaglandin stimulus GO:0071379 2 0.013
dna metabolic process GO:0006259 303 0.013
digestive tract development GO:0048565 190 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
hormone secretion GO:0046879 128 0.013
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.013
positive regulation of protein transport GO:0051222 93 0.013
golgi vesicle transport GO:0048193 30 0.013
Human
regulation of systemic arterial blood pressure by vasopressin GO:0001992 3 0.013
lymphocyte proliferation GO:0046651 164 0.013
negative regulation of defense response GO:0031348 77 0.013
regulation of cell motility GO:2000145 236 0.013
mitotic cytokinesis GO:0000281 4 0.013
signal transduction by p53 class mediator GO:0072331 51 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
regulation of nfat protein import into nucleus GO:0051532 4 0.013
female meiotic division GO:0007143 21 0.012
regulation of anatomical structure size GO:0090066 178 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
regulation of cellular amine metabolic process GO:0033238 20 0.012
striated muscle cell development GO:0055002 125 0.012
positive regulation of nervous system development GO:0051962 221 0.012
neuron death GO:0070997 154 0.012
cell cycle switching mitotic to meiotic cell cycle GO:0051728 1 0.012
response to temperature stimulus GO:0009266 55 0.012
regulation of innate immune response GO:0045088 91 0.012
regulation of transmembrane transport GO:0034762 128 0.012
carbohydrate homeostasis GO:0033500 128 0.012
protein polymerization GO:0051258 57 0.012
regulation of high voltage gated calcium channel activity GO:1901841 2 0.012
microtubule cytoskeleton organization GO:0000226 157 0.012
cerebellar cortex development GO:0021695 48 0.012
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.012
regulation of cardiac muscle adaptation GO:0010612 2 0.011
regulation of cellular response to growth factor stimulus GO:0090287 82 0.011
leukocyte homeostasis GO:0001776 79 0.011
double strand break repair GO:0006302 48 0.011
peptidyl amino acid modification GO:0018193 336 0.011
response to light stimulus GO:0009416 135 0.011
regulation of mapk cascade GO:0043408 248 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
regulation of muscle system process GO:0090257 80 0.011
cell type specific apoptotic process GO:0097285 268 0.011
androgen receptor signaling pathway GO:0030521 8 0.011
n terminal protein lipidation GO:0006498 5 0.011
dna templated transcriptional preinitiation complex assembly GO:0070897 4 0.011
phagocytosis GO:0006909 66 0.011
positive regulation of transcription factor import into nucleus GO:0042993 8 0.011
sensory perception of touch GO:0050975 2 0.011
regulation of peptide transport GO:0090087 91 0.011
negative regulation of dna replication GO:0008156 4 0.011
regulation of actin filament based process GO:0032970 99 0.011
regulation of ran gtpase activity GO:0032316 3 0.011
cytokinesis GO:0000910 17 0.011
Human
t cell activation GO:0042110 289 0.011
negative regulation of protein transport GO:0051224 46 0.010
synapse assembly GO:0007416 56 0.010
regulation of histone modification GO:0031056 56 0.010
calcium ion transport GO:0006816 159 0.010
bmp signaling pathway GO:0030509 93 0.010
positive regulation of apoptotic process GO:0043065 217 0.010
regulation of neural precursor cell proliferation GO:2000177 70 0.010
establishment or maintenance of cell polarity GO:0007163 86 0.010
neural tube closure GO:0001843 90 0.010
determination of left right symmetry GO:0007368 80 0.010
response to monosaccharide GO:0034284 67 0.010
microtubule based process GO:0007017 236 0.010
response to molecule of bacterial origin GO:0002237 143 0.010

Cul3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
nervous system disease DOID:863 0 0.052
sensory system disease DOID:0050155 0 0.039
eye and adnexa disease DOID:1492 0 0.039
motor neuron disease DOID:231 0 0.027
central nervous system disease DOID:331 0 0.027
amyotrophic lateral sclerosis DOID:332 0 0.027
neurodegenerative disease DOID:1289 0 0.027
musculoskeletal system disease DOID:17 0 0.014
endocrine gland cancer DOID:170 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011