Mus musculus

98 known processes

Dld

dihydrolipoamide dehydrogenase

(Aliases: AI315664,AI746344)

Dld biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion organization GO:0007005 134 0.188
nucleobase containing small molecule metabolic process GO:0055086 352 0.154
organic cyclic compound catabolic process GO:1901361 295 0.140
protein localization to organelle GO:0033365 185 0.135
mitochondrial transport GO:0006839 36 0.130
purine ribonucleoside metabolic process GO:0046128 241 0.102
glycosyl compound metabolic process GO:1901657 246 0.096
purine ribonucleotide metabolic process GO:0009150 290 0.095
regulation of apoptotic signaling pathway GO:2001233 197 0.079
male gamete generation GO:0048232 285 0.075
nucleoside phosphate metabolic process GO:0006753 338 0.074
response to radiation GO:0009314 165 0.072
dna metabolic process GO:0006259 303 0.070
intracellular protein transport GO:0006886 204 0.068
regulation of mitochondrial fission GO:0090140 3 0.064
macromolecule catabolic process GO:0009057 281 0.063
protein processing GO:0016485 163 0.062
nitrogen compound transport GO:0071705 271 0.062
cellular amino acid metabolic process GO:0006520 103 0.059
spermatid differentiation GO:0048515 115 0.055
protein targeting GO:0006605 143 0.054
transmembrane transport GO:0055085 412 0.050
organonitrogen compound biosynthetic process GO:1901566 192 0.050
heterocycle catabolic process GO:0046700 280 0.050
ribose phosphate metabolic process GO:0019693 291 0.050
endocytosis GO:0006897 168 0.050
Worm
positive regulation of hydrolase activity GO:0051345 148 0.050
regulation of organelle organization GO:0033043 289 0.049
regulation of cellular catabolic process GO:0031329 242 0.046
protein maturation GO:0051604 176 0.043
regulation of hydrolase activity GO:0051336 246 0.043
regulation of cell cycle process GO:0010564 160 0.040
response to light stimulus GO:0009416 135 0.040
negative regulation of phosphorylation GO:0042326 166 0.040
negative regulation of protein metabolic process GO:0051248 282 0.039
nucleotide metabolic process GO:0009117 332 0.038
sulfur compound biosynthetic process GO:0044272 37 0.038
translation GO:0006412 93 0.037
purine nucleoside monophosphate metabolic process GO:0009126 81 0.037
regulation of proteolysis GO:0030162 164 0.036
cellular response to dna damage stimulus GO:0006974 207 0.036
monocarboxylic acid metabolic process GO:0032787 191 0.035
positive regulation of cell death GO:0010942 224 0.035
striated muscle tissue development GO:0014706 293 0.035
cytoplasmic transport GO:0016482 234 0.035
nucleobase containing compound transport GO:0015931 27 0.034
protein catabolic process GO:0030163 221 0.034
multicellular organismal aging GO:0010259 24 0.032
Worm
establishment of protein localization to organelle GO:0072594 118 0.032
protein targeting to peroxisome GO:0006625 4 0.031
regulation of stress activated mapk cascade GO:0032872 69 0.031
acetyl coa biosynthetic process from pyruvate GO:0006086 3 0.031
neuron apoptotic process GO:0051402 142 0.031
protein targeting to mitochondrion GO:0006626 6 0.030
amine metabolic process GO:0009308 45 0.030
peroxisomal transport GO:0043574 4 0.030
positive regulation of proteolysis GO:0045862 85 0.030
protein localization to mitochondrion GO:0070585 15 0.030
regulation of membrane potential GO:0042391 192 0.029
cellular macromolecule catabolic process GO:0044265 206 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.028
reactive oxygen species metabolic process GO:0072593 84 0.027
regulation of cellular response to stress GO:0080135 159 0.027
negative regulation of phosphorus metabolic process GO:0010563 184 0.027
intrinsic apoptotic signaling pathway GO:0097193 132 0.027
cellular homeostasis GO:0019725 240 0.026
oxidation reduction process GO:0055114 342 0.026
negative regulation of intracellular signal transduction GO:1902532 167 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
ribonucleoside monophosphate metabolic process GO:0009161 80 0.025
generation of precursor metabolites and energy GO:0006091 103 0.025
aromatic compound catabolic process GO:0019439 286 0.025
atp metabolic process GO:0046034 75 0.025
monocarboxylic acid biosynthetic process GO:0072330 61 0.025
regulation of peptidase activity GO:0052547 96 0.025
negative regulation of cell morphogenesis involved in differentiation GO:0010771 48 0.025
negative regulation of cell development GO:0010721 169 0.025
protein oligomerization GO:0051259 67 0.024
establishment of protein localization to peroxisome GO:0072663 4 0.024
regulation of vesicle mediated transport GO:0060627 139 0.024
cellular nitrogen compound catabolic process GO:0044270 280 0.024
tissue migration GO:0090130 68 0.023
regulation of cell cycle GO:0051726 281 0.023
regulation of endopeptidase activity GO:0052548 89 0.023
small molecule biosynthetic process GO:0044283 132 0.022
regulation of secretion GO:0051046 274 0.022
sulfur compound metabolic process GO:0006790 100 0.022
negative regulation of phosphate metabolic process GO:0045936 184 0.022
regulation of reactive oxygen species metabolic process GO:2000377 40 0.021
guanosine containing compound metabolic process GO:1901068 144 0.021
mitochondrion degradation GO:0000422 3 0.021
cation homeostasis GO:0055080 212 0.021
purine containing compound metabolic process GO:0072521 311 0.021
skeletal system development GO:0001501 356 0.020
nucleoside triphosphate catabolic process GO:0009143 205 0.020
proteasomal protein catabolic process GO:0010498 98 0.020
apoptotic signaling pathway GO:0097190 306 0.020
gland development GO:0048732 330 0.019
gtp catabolic process GO:0006184 143 0.019
mapk cascade GO:0000165 281 0.019
response to transforming growth factor beta GO:0071559 88 0.019
protein import into peroxisome matrix GO:0016558 3 0.019
organonitrogen compound catabolic process GO:1901565 264 0.019
small molecule catabolic process GO:0044282 71 0.018
ribonucleoside triphosphate metabolic process GO:0009199 220 0.018
cellular protein catabolic process GO:0044257 155 0.018
forebrain development GO:0030900 302 0.018
carbohydrate derivative catabolic process GO:1901136 231 0.018
maintenance of location GO:0051235 89 0.018
cellular ketone metabolic process GO:0042180 84 0.018
regulation of cellular response to growth factor stimulus GO:0090287 82 0.017
organophosphate catabolic process GO:0046434 232 0.017
gonad development GO:0008406 141 0.017
localization within membrane GO:0051668 4 0.017
regulation of cellular ketone metabolic process GO:0010565 66 0.017
purine nucleoside triphosphate catabolic process GO:0009146 203 0.017
purine ribonucleotide catabolic process GO:0009154 208 0.017
response to growth factor GO:0070848 198 0.017
purine nucleotide metabolic process GO:0006163 302 0.017
cellular response to cytokine stimulus GO:0071345 189 0.017
circulatory system process GO:0003013 197 0.017
purine ribonucleoside catabolic process GO:0046130 205 0.017
dephosphorylation GO:0016311 129 0.017
organic hydroxy compound metabolic process GO:1901615 203 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.016
peptide transport GO:0015833 133 0.016
energy derivation by oxidation of organic compounds GO:0015980 77 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
neuron neuron synaptic transmission GO:0007270 69 0.016
amide transport GO:0042886 138 0.016
regulation of secretion by cell GO:1903530 249 0.016
negative regulation of apoptotic signaling pathway GO:2001234 104 0.016
cellular response to growth factor stimulus GO:0071363 197 0.016
negative regulation of cellular component organization GO:0051129 194 0.016
positive regulation of programmed cell death GO:0043068 218 0.015
response to molecule of bacterial origin GO:0002237 143 0.015
leukocyte proliferation GO:0070661 172 0.015
cellular amine metabolic process GO:0044106 44 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
coenzyme biosynthetic process GO:0009108 23 0.015
cell adhesion GO:0007155 329 0.015
mitotic cell cycle GO:0000278 195 0.015
modification dependent macromolecule catabolic process GO:0043632 133 0.015
camera type eye development GO:0043010 266 0.015
mesenchymal cell differentiation GO:0048762 107 0.015
response to oxidative stress GO:0006979 123 0.015
inflammatory response GO:0006954 244 0.015
muscle tissue development GO:0060537 308 0.015
ion transmembrane transport GO:0034220 361 0.015
nucleoside phosphate catabolic process GO:1901292 222 0.014
regulation of cell migration GO:0030334 219 0.014
negative regulation of protein phosphorylation GO:0001933 126 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
nucleotide catabolic process GO:0009166 217 0.014
protein neddylation GO:0045116 1 0.014
t cell activation GO:0042110 289 0.014
organic acid biosynthetic process GO:0016053 86 0.014
metal ion homeostasis GO:0055065 189 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.014
negative regulation of molecular function GO:0044092 258 0.014
organelle fission GO:0048285 170 0.014
centrosome separation GO:0051299 4 0.014
phospholipid metabolic process GO:0006644 87 0.014
carbohydrate homeostasis GO:0033500 128 0.014
purine containing compound catabolic process GO:0072523 213 0.014
cell division GO:0051301 120 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
molting cycle GO:0042303 90 0.013
protein secretion GO:0009306 111 0.013
carbohydrate metabolic process GO:0005975 230 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
t cell proliferation GO:0042098 120 0.013
positive regulation of secretion by cell GO:1903532 114 0.013
telencephalon development GO:0021537 186 0.013
regulation of cellular amine metabolic process GO:0033238 20 0.013
blood circulation GO:0008015 195 0.013
regulation of chromosome organization GO:0033044 83 0.013
endomembrane system organization GO:0010256 147 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.013
membrane organization GO:0061024 245 0.013
Worm
spermatogenesis GO:0007283 284 0.013
vasodilation GO:0042311 28 0.013
regulation of establishment of protein localization GO:0070201 181 0.013
response to inorganic substance GO:0010035 96 0.013
germ cell development GO:0007281 185 0.013
regulation of peptide transport GO:0090087 91 0.013
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.013
regulation of lipid metabolic process GO:0019216 118 0.012
dna repair GO:0006281 107 0.012
cell type specific apoptotic process GO:0097285 268 0.012
lipid localization GO:0010876 126 0.012
guanosine containing compound catabolic process GO:1901069 144 0.012
neuron death GO:0070997 154 0.012
positive regulation of apoptotic process GO:0043065 217 0.012
establishment of protein localization to mitochondrion GO:0072655 11 0.012
exocytosis GO:0006887 121 0.012
response to organonitrogen compound GO:0010243 246 0.012
positive regulation of meiosis i GO:0060903 5 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.012
protein import GO:0017038 101 0.012
negative regulation of cell proliferation GO:0008285 296 0.012
purine nucleoside catabolic process GO:0006152 205 0.012
positive regulation of protein modification process GO:0031401 299 0.012
ribonucleotide catabolic process GO:0009261 208 0.012
regulation of cytoplasmic transport GO:1903649 112 0.012
homeostasis of number of cells GO:0048872 210 0.012
thioester biosynthetic process GO:0035384 7 0.012
positive regulation of dna templated transcription elongation GO:0032786 2 0.012
immune effector process GO:0002252 321 0.011
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.011
regulation of neuron apoptotic process GO:0043523 122 0.011
histone modification GO:0016570 159 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
regulation of cellular amino acid metabolic process GO:0006521 5 0.011
acyl coa biosynthetic process GO:0071616 7 0.011
lipid oxidation GO:0034440 29 0.011
protein transmembrane transport GO:0071806 8 0.011
cellular response to organonitrogen compound GO:0071417 145 0.011
protein modification by small protein conjugation GO:0032446 187 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.011
protein localization to membrane GO:0072657 108 0.011
hormone secretion GO:0046879 128 0.011
regulation of cell motility GO:2000145 236 0.011
organic hydroxy compound transport GO:0015850 93 0.011
negative regulation of mitotic cell cycle GO:0045930 58 0.011
regulation of kinase activity GO:0043549 249 0.011
regulation of response to wounding GO:1903034 189 0.011
regulation of cell activation GO:0050865 289 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
phagocytosis GO:0006909 66 0.011
Worm
multicellular organismal homeostasis GO:0048871 164 0.011
response to extracellular stimulus GO:0009991 127 0.011
cation transport GO:0006812 399 0.011
cellular lipid metabolic process GO:0044255 323 0.011
chromatin modification GO:0016568 187 0.011
locomotory behavior GO:0007626 195 0.011
stress activated mapk cascade GO:0051403 80 0.011
endoplasmic reticulum organization GO:0007029 10 0.010
positive regulation of secretion GO:0051047 130 0.010
negative regulation of protein processing GO:0010955 79 0.010
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 34 0.010
positive regulation of protein kinase activity GO:0045860 144 0.010
lymphocyte proliferation GO:0046651 164 0.010
glucose homeostasis GO:0042593 128 0.010
positive regulation of organelle organization GO:0010638 128 0.010
negative regulation of cell cycle process GO:0010948 69 0.010
nucleoside metabolic process GO:0009116 246 0.010
ras protein signal transduction GO:0007265 77 0.010
canonical wnt signaling pathway GO:0060070 130 0.010
lipid biosynthetic process GO:0008610 179 0.010
cellular response to oxidative stress GO:0034599 76 0.010
cerebral cortex development GO:0021987 86 0.010
regulation of hormone levels GO:0010817 211 0.010

Dld disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.027
Human
inherited metabolic disorder DOID:655 0 0.027
Human
immune system disease DOID:2914 0 0.023
blood coagulation disease DOID:1247 0 0.023
disease of anatomical entity DOID:7 0 0.023
hematopoietic system disease DOID:74 0 0.023
central nervous system disease DOID:331 0 0.012
nervous system disease DOID:863 0 0.012
neurodegenerative disease DOID:1289 0 0.012