Mus musculus

0 known processes

Dna2

DNA replication helicase 2 homolog (yeast)

(Aliases: E130315B21Rik,Dna2l,KIAA0083)

Dna2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna metabolic process GO:0006259 303 0.829
Human
protection from non homologous end joining at telomere GO:0031848 4 0.737
telomere maintenance in response to dna damage GO:0043247 4 0.713
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.520
cellular response to dna damage stimulus GO:0006974 207 0.468
Human
telomere capping GO:0016233 4 0.428
dna replication GO:0006260 52 0.351
Human
chromatin modification GO:0016568 187 0.288
negative regulation of cell cycle phase transition GO:1901988 48 0.267
microtubule based process GO:0007017 236 0.259
chromatin organization GO:0006325 206 0.236
negative regulation of cell cycle GO:0045786 123 0.228
dna biosynthetic process GO:0071897 22 0.227
negative regulation of mitotic cell cycle GO:0045930 58 0.217
mitotic cell cycle GO:0000278 195 0.215
mitotic cell cycle process GO:1903047 159 0.213
chromosome segregation GO:0007059 48 0.205
regulation of mitotic cell cycle GO:0007346 126 0.193
regulation of cell division GO:0051302 76 0.188
dna endoreduplication GO:0042023 4 0.170
regulation of cell cycle GO:0051726 281 0.165
histone threonine phosphorylation GO:0035405 1 0.154
cellular macromolecule catabolic process GO:0044265 206 0.150
Human
negative regulation of cellular component organization GO:0051129 194 0.150
cellular protein catabolic process GO:0044257 155 0.149
organic cyclic compound catabolic process GO:1901361 295 0.146
Human
cell division GO:0051301 120 0.135
regulation of cell cycle process GO:0010564 160 0.132
microtubule cytoskeleton organization GO:0000226 157 0.126
dna repair GO:0006281 107 0.124
Human
regulation of cell cycle phase transition GO:1901987 77 0.117
nucleoside metabolic process GO:0009116 246 0.117
Human
cellular nitrogen compound catabolic process GO:0044270 280 0.114
Human
nucleobase containing small molecule metabolic process GO:0055086 352 0.112
Human
regulation of cellular catabolic process GO:0031329 242 0.112
purine nucleotide metabolic process GO:0006163 302 0.111
Human
mitotic sister chromatid segregation GO:0000070 14 0.110
regulation of mitotic cell cycle phase transition GO:1901990 73 0.106
dna packaging GO:0006323 30 0.105
mitotic nuclear division GO:0007067 48 0.103
organelle fission GO:0048285 170 0.102
female meiosis chromosome segregation GO:0016321 1 0.097
positive regulation of cell cycle GO:0045787 92 0.097
organonitrogen compound catabolic process GO:1901565 264 0.096
Human
translesion synthesis GO:0019985 1 0.093
cell cycle checkpoint GO:0000075 47 0.091
Human
centrosome separation GO:0051299 4 0.091
nucleoside phosphate metabolic process GO:0006753 338 0.086
Human
regulation of nuclear cell cycle dna replication GO:0033262 2 0.086
organelle assembly GO:0070925 177 0.085
nuclear division GO:0000280 158 0.084
purine nucleoside metabolic process GO:0042278 241 0.084
Human
regulation of organelle organization GO:0033043 289 0.083
intrinsic apoptotic signaling pathway GO:0097193 132 0.082
macromolecule catabolic process GO:0009057 281 0.081
Human
positive regulation of cell death GO:0010942 224 0.080
nucleoside catabolic process GO:0009164 206 0.072
Human
negative regulation of cell cycle process GO:0010948 69 0.070
negative regulation of dna replication GO:0008156 4 0.068
gonad development GO:0008406 141 0.068
regulation of mitosis GO:0007088 29 0.066
peptidyl amino acid modification GO:0018193 336 0.066
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.065
cellular amino acid metabolic process GO:0006520 103 0.064
regulation of cellular amino acid metabolic process GO:0006521 5 0.062
aromatic compound catabolic process GO:0019439 286 0.061
Human
protein maturation GO:0051604 176 0.060
purine ribonucleotide metabolic process GO:0009150 290 0.060
Human
methylation GO:0032259 134 0.059
sister chromatid segregation GO:0000819 20 0.059
protein catabolic process GO:0030163 221 0.059
nucleoside phosphate catabolic process GO:1901292 222 0.058
Human
heterocycle catabolic process GO:0046700 280 0.057
Human
cellular ketone metabolic process GO:0042180 84 0.057
genitalia development GO:0048806 37 0.057
cellular amine metabolic process GO:0044106 44 0.056
ribonucleoside triphosphate metabolic process GO:0009199 220 0.055
Human
nucleoside triphosphate metabolic process GO:0009141 230 0.055
Human
apoptotic signaling pathway GO:0097190 306 0.054
negative regulation of organelle organization GO:0010639 90 0.052
regulation of cellular amine metabolic process GO:0033238 20 0.052
gene silencing GO:0016458 38 0.052
positive regulation of programmed cell death GO:0043068 218 0.052
protein processing GO:0016485 163 0.051
meiotic cell cycle GO:0051321 122 0.051
ribonucleoside metabolic process GO:0009119 245 0.051
Human
positive regulation of apoptotic process GO:0043065 217 0.051
purine nucleoside triphosphate catabolic process GO:0009146 203 0.048
Human
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.048
establishment of organelle localization GO:0051656 122 0.047
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.047
Human
modification dependent protein catabolic process GO:0019941 133 0.047
synapsis GO:0007129 34 0.046
positive regulation of cell development GO:0010720 237 0.046
response to organonitrogen compound GO:0010243 246 0.045
carbohydrate derivative catabolic process GO:1901136 231 0.044
Human
ribonucleotide catabolic process GO:0009261 208 0.044
Human
ribonucleoside catabolic process GO:0042454 206 0.044
Human
ribonucleoside triphosphate catabolic process GO:0009203 199 0.043
Human
organophosphate catabolic process GO:0046434 232 0.043
Human
development of primary sexual characteristics GO:0045137 143 0.043
positive regulation of organelle organization GO:0010638 128 0.042
regulation of apoptotic signaling pathway GO:2001233 197 0.042
mitotic cell cycle checkpoint GO:0007093 31 0.042
spindle assembly involved in mitosis GO:0090307 4 0.041
amine metabolic process GO:0009308 45 0.041
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.041
Human
glycosyl compound catabolic process GO:1901658 206 0.041
Human
negative regulation of cellular amine metabolic process GO:0033239 1 0.040
positive regulation of hydrolase activity GO:0051345 148 0.040
ribose phosphate metabolic process GO:0019693 291 0.040
Human
nucleotide catabolic process GO:0009166 217 0.039
Human
regulation of dna dependent dna replication GO:0090329 8 0.039
protein localization to organelle GO:0033365 185 0.039
mitotic recombination GO:0006312 3 0.039
regulation of transferase activity GO:0051338 263 0.038
purine nucleoside triphosphate metabolic process GO:0009144 226 0.038
Human
negative regulation of cell division GO:0051782 24 0.038
purine ribonucleotide catabolic process GO:0009154 208 0.038
Human
regulation of hydrolase activity GO:0051336 246 0.036
dna recombination GO:0006310 92 0.036
nucleotide metabolic process GO:0009117 332 0.036
Human
ras protein signal transduction GO:0007265 77 0.035
mitotic sister chromatid separation GO:0051306 9 0.035
endomembrane system organization GO:0010256 147 0.035
regulation of homeostatic process GO:0032844 182 0.035
protein ubiquitination GO:0016567 171 0.035
dna replication independent nucleosome assembly GO:0006336 1 0.035
nucleoside triphosphate catabolic process GO:0009143 205 0.035
Human
positive regulation of cellular amine metabolic process GO:0033240 5 0.035
cell cycle g1 s phase transition GO:0044843 57 0.034
regulation of nuclear division GO:0051783 56 0.034
mitotic chromosome condensation GO:0007076 1 0.033
purine nucleotide catabolic process GO:0006195 211 0.033
Human
histone modification GO:0016570 159 0.033
regulation of chromosome organization GO:0033044 83 0.032
anatomical structure homeostasis GO:0060249 145 0.032
cellular protein complex assembly GO:0043623 116 0.032
regulation of mitotic sister chromatid segregation GO:0033047 12 0.031
regulation of cellular ketone metabolic process GO:0010565 66 0.031
positive regulation of protein modification process GO:0031401 299 0.031
chromosome separation GO:0051304 14 0.031
regulation of dna replication GO:0006275 17 0.031
Human
regulation of cytoskeleton organization GO:0051493 122 0.030
covalent chromatin modification GO:0016569 163 0.030
positive regulation of cell cycle process GO:0090068 61 0.030
protein polymerization GO:0051258 57 0.030
maintenance of location GO:0051235 89 0.030
purine nucleoside catabolic process GO:0006152 205 0.029
Human
urogenital system development GO:0001655 261 0.029
purine containing compound metabolic process GO:0072521 311 0.029
Human
positive regulation of homeostatic process GO:0032846 64 0.028
angiogenesis GO:0001525 201 0.028
positive regulation of chromosome organization GO:2001252 33 0.028
cellular response to organonitrogen compound GO:0071417 145 0.028
purine ribonucleoside metabolic process GO:0046128 241 0.028
Human
negative regulation of chromosome organization GO:2001251 30 0.027
response to radiation GO:0009314 165 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.027
negative regulation of mitosis GO:0045839 10 0.027
negative regulation of protein metabolic process GO:0051248 282 0.027
negative regulation of cellular protein metabolic process GO:0032269 247 0.027
glycosyl compound metabolic process GO:1901657 246 0.027
Human
astral microtubule organization GO:0030953 3 0.027
spindle checkpoint GO:0031577 12 0.027
cation transport GO:0006812 399 0.027
chromatin remodeling at centromere GO:0031055 2 0.026
negative regulation of molecular function GO:0044092 258 0.026
b cell activation GO:0042113 161 0.026
negative regulation of transferase activity GO:0051348 85 0.026
protein dna complex subunit organization GO:0071824 28 0.026
protein oligomerization GO:0051259 67 0.026
ribonucleotide metabolic process GO:0009259 291 0.026
Human
negative regulation of protein processing GO:0010955 79 0.026
regulation of purine nucleotide catabolic process GO:0033121 122 0.026
heterochromatin organization GO:0070828 4 0.025
g1 s transition of mitotic cell cycle GO:0000082 57 0.025
negative regulation of homeostatic process GO:0032845 71 0.025
protein localization to chromosome GO:0034502 6 0.025
ubiquitin dependent protein catabolic process GO:0006511 129 0.025
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.025
Human
purine nucleoside monophosphate metabolic process GO:0009126 81 0.025
Human
dna conformation change GO:0071103 37 0.024
Human
centrosome cycle GO:0007098 23 0.024
modification dependent macromolecule catabolic process GO:0043632 133 0.024
mitotic sister chromatid cohesion GO:0007064 1 0.024
cell fate commitment GO:0045165 210 0.024
spermatogenesis GO:0007283 284 0.024
cellular lipid metabolic process GO:0044255 323 0.024
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.024
nuclear dna replication GO:0033260 3 0.024
positive regulation of meiosis i GO:0060903 5 0.024
gland development GO:0048732 330 0.024
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.023
blood vessel morphogenesis GO:0048514 285 0.023
regulation of cellular component biogenesis GO:0044087 181 0.023
synaptonemal complex assembly GO:0007130 13 0.023
regulation of nucleotide metabolic process GO:0006140 169 0.023
proteasomal protein catabolic process GO:0010498 98 0.023
chromatin assembly or disassembly GO:0006333 16 0.022
cellular homeostasis GO:0019725 240 0.022
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.022
digestive system development GO:0055123 200 0.022
wnt signaling pathway GO:0016055 188 0.022
fertilization GO:0009566 127 0.021
purine containing compound catabolic process GO:0072523 213 0.021
Human
negative regulation of sister chromatid segregation GO:0033046 7 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.021
mitochondrion organization GO:0007005 134 0.021
Human
dna alkylation GO:0006305 43 0.021
negative regulation of cell proliferation GO:0008285 296 0.021
meiotic nuclear division GO:0007126 115 0.021
positive regulation of nervous system development GO:0051962 221 0.020
positive regulation of nucleotide metabolic process GO:0045981 114 0.020
regulation of protein processing GO:0070613 96 0.020
leukocyte proliferation GO:0070661 172 0.020
placenta development GO:0001890 140 0.020
positive regulation of microtubule polymerization or depolymerization GO:0031112 3 0.020
immune effector process GO:0002252 321 0.020
regulation of purine nucleotide metabolic process GO:1900542 169 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.020
myeloid cell differentiation GO:0030099 233 0.020
macromolecule methylation GO:0043414 120 0.020
regulation of histone modification GO:0031056 56 0.020
forebrain development GO:0030900 302 0.020
meiotic chromosome segregation GO:0045132 19 0.020
regulation of protein localization GO:0032880 231 0.020
lymphocyte proliferation GO:0046651 164 0.019
positive regulation of cellular catabolic process GO:0031331 148 0.019
rna interference GO:0016246 2 0.019
membrane organization GO:0061024 245 0.019
cell cycle g2 m phase transition GO:0044839 20 0.019
microtubule organizing center organization GO:0031023 28 0.019
regulation of proteolysis GO:0030162 164 0.019
posttranscriptional regulation of gene expression GO:0010608 155 0.018
purine ribonucleoside catabolic process GO:0046130 205 0.018
Human
spermatid differentiation GO:0048515 115 0.018
multicellular organism growth GO:0035264 161 0.018
hepaticobiliary system development GO:0061008 67 0.018
response to organic cyclic compound GO:0014070 198 0.018
anion transport GO:0006820 177 0.018
rna dependent dna replication GO:0006278 3 0.018
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.018
positive regulation of mitotic cell cycle GO:0045931 41 0.018
regulation of protein kinase activity GO:0045859 232 0.018
ribonucleoside monophosphate metabolic process GO:0009161 80 0.018
Human
small gtpase mediated signal transduction GO:0007264 97 0.018
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.017
leukocyte differentiation GO:0002521 342 0.017
dna methylation GO:0006306 43 0.017
peptidyl serine phosphorylation GO:0018105 74 0.017
regulation of protein maturation GO:1903317 96 0.017
negative regulation of protein maturation GO:1903318 79 0.017
negative regulation of intracellular signal transduction GO:1902532 167 0.017
mitotic cytokinesis GO:0000281 4 0.017
rho protein signal transduction GO:0007266 32 0.017
regulation of nucleoside metabolic process GO:0009118 130 0.017
double strand break repair via homologous recombination GO:0000724 21 0.017
dna modification GO:0006304 50 0.017
nucleoside monophosphate metabolic process GO:0009123 85 0.017
Human
nitrogen compound transport GO:0071705 271 0.017
oxidation reduction process GO:0055114 342 0.017
cell type specific apoptotic process GO:0097285 268 0.016
meiosis i GO:0007127 60 0.016
regulation of wnt signaling pathway GO:0030111 123 0.016
morphogenesis of embryonic epithelium GO:0016331 159 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
regulation of secretion GO:0051046 274 0.016
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.016
regulation of cell activation GO:0050865 289 0.016
spindle organization GO:0007051 28 0.016
regulation of lymphocyte activation GO:0051249 240 0.015
chromatin assembly GO:0031497 13 0.015
protein acylation GO:0043543 64 0.015
regulation of meiosis i GO:0060631 7 0.015
positive regulation of cell division GO:0051781 31 0.015
male gamete generation GO:0048232 285 0.015
endocytosis GO:0006897 168 0.015
blastocyst development GO:0001824 80 0.015
gtp metabolic process GO:0046039 144 0.015
regulation of map kinase activity GO:0043405 120 0.015
spindle assembly involved in meiosis GO:0090306 4 0.015
cell adhesion GO:0007155 329 0.015
double strand break repair GO:0006302 48 0.014
Human
mesodermal cell migration GO:0008078 4 0.014
histone h3 k9 acetylation GO:0043970 5 0.014
metaphase plate congression GO:0051310 2 0.014
b cell differentiation GO:0030183 78 0.014
regulation of defense response GO:0031347 233 0.014
cell aging GO:0007569 35 0.014
regulation of cellular response to stress GO:0080135 159 0.014
organelle localization GO:0051640 179 0.014
divalent metal ion transport GO:0070838 172 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.014
monocarboxylic acid metabolic process GO:0032787 191 0.014
mapk cascade GO:0000165 281 0.014
positive regulation of nuclear division GO:0051785 27 0.014
spindle assembly involved in female meiosis GO:0007056 3 0.014
guanosine containing compound metabolic process GO:1901068 144 0.014
cellular response to growth factor stimulus GO:0071363 197 0.014
glucose homeostasis GO:0042593 128 0.014
positive regulation of protein kinase activity GO:0045860 144 0.014
regulation of nucleotide catabolic process GO:0030811 122 0.014
negative regulation of immune system process GO:0002683 209 0.014
negative regulation of apoptotic signaling pathway GO:2001234 104 0.014
response to light stimulus GO:0009416 135 0.014
sensory perception GO:0007600 245 0.013
response to growth factor GO:0070848 198 0.013
negative regulation of nuclear division GO:0051784 19 0.013
primary neural tube formation GO:0014020 95 0.013
leukocyte activation involved in immune response GO:0002366 126 0.013
neuron migration GO:0001764 122 0.013
dna ligation GO:0006266 3 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.013
regulation of protein complex assembly GO:0043254 83 0.013
extrinsic apoptotic signaling pathway GO:0097191 126 0.013
leukocyte mediated immunity GO:0002443 174 0.013
mrna processing GO:0006397 63 0.013
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 9 0.013
positive regulation of gtp catabolic process GO:0033126 85 0.013
striated muscle myosin thick filament assembly GO:0071688 1 0.013
carbohydrate homeostasis GO:0033500 128 0.013
camera type eye development GO:0043010 266 0.013
lymphocyte differentiation GO:0030098 242 0.013
histone phosphorylation GO:0016572 9 0.013
gastrulation GO:0007369 116 0.012
single fertilization GO:0007338 82 0.012
regulation of chromosome segregation GO:0051983 21 0.012
atp metabolic process GO:0046034 75 0.012
Human
guanosine containing compound catabolic process GO:1901069 144 0.012
epithelial tube formation GO:0072175 130 0.012
regulation of cell motility GO:2000145 236 0.012
reciprocal meiotic recombination GO:0007131 16 0.012
homeostasis of number of cells GO:0048872 210 0.012
chorion development GO:0060717 7 0.012
regulation of proteasomal protein catabolic process GO:0061136 46 0.012
cellular response to cytokine stimulus GO:0071345 189 0.012
positive regulation of protein complex assembly GO:0031334 45 0.012
humoral immune response GO:0006959 57 0.012
sister chromatid cohesion GO:0007062 12 0.012
reciprocal dna recombination GO:0035825 16 0.012
regulation of cell cycle g2 m phase transition GO:1902749 10 0.012
chemotaxis GO:0006935 247 0.012
histone acetylation GO:0016573 41 0.012
epithelial cell proliferation GO:0050673 174 0.012
cytokine production GO:0001816 319 0.012
digestive tract development GO:0048565 190 0.012
positive regulation of cytoskeleton organization GO:0051495 49 0.012
regulation of cytokine production GO:0001817 266 0.012
regulation of neuron differentiation GO:0045664 281 0.012
protein modification by small protein conjugation or removal GO:0070647 207 0.012
innate immune response GO:0045087 157 0.012
intracellular protein transport GO:0006886 204 0.012
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.012
Human
negative regulation of mitotic sister chromatid segregation GO:0033048 7 0.012
muscle cell differentiation GO:0042692 261 0.011
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.011
regulation of epithelial cell proliferation GO:0050678 141 0.011
neural tube closure GO:0001843 90 0.011
peptidyl serine modification GO:0018209 83 0.011
tube formation GO:0035148 140 0.011
positive regulation of immune effector process GO:0002699 107 0.011
locomotory behavior GO:0007626 195 0.011
dna integrity checkpoint GO:0031570 28 0.011
Human
centromere complex assembly GO:0034508 3 0.011
embryonic placenta development GO:0001892 98 0.011
negative regulation of mitotic metaphase anaphase transition GO:0045841 7 0.011
regulation of cellular component size GO:0032535 121 0.011
cellularization GO:0007349 1 0.011
positive regulation of kinase activity GO:0033674 155 0.011
retrograde transport endosome to golgi GO:0042147 2 0.011
embryonic organ morphogenesis GO:0048562 276 0.011
peptidyl threonine modification GO:0018210 31 0.011
cellular chemical homeostasis GO:0055082 215 0.011
g2 m transition of mitotic cell cycle GO:0000086 20 0.011
pharynx development GO:0060465 1 0.011
positive regulation of transferase activity GO:0051347 167 0.011
positive regulation of cellular component biogenesis GO:0044089 94 0.011
regulation of endopeptidase activity GO:0052548 89 0.011
protein localization to chromatin GO:0071168 3 0.011
epithelial tube morphogenesis GO:0060562 303 0.011
apoptotic nuclear changes GO:0030262 9 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
positive regulation of histone modification GO:0031058 28 0.011
telomere maintenance GO:0000723 19 0.011
positive regulation of cytokine production GO:0001819 174 0.010
telencephalon development GO:0021537 186 0.010
positive regulation of nucleoside metabolic process GO:0045979 91 0.010
action potential GO:0001508 78 0.010
developmental maturation GO:0021700 193 0.010
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.010
cell growth GO:0016049 130 0.010
regulation of response to wounding GO:1903034 189 0.010
telomere maintenance via telomerase GO:0007004 1 0.010
dna catabolic process exonucleolytic GO:0000738 3 0.010
Human
wound healing GO:0042060 157 0.010
spindle assembly GO:0051225 13 0.010
negative regulation of proteolysis GO:0045861 74 0.010
inflammatory response GO:0006954 244 0.010
morphogenesis of a branching epithelium GO:0061138 193 0.010
establishment of protein localization to organelle GO:0072594 118 0.010

Dna2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.030
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.013
physical disorder DOID:0080015 0 0.012
hematopoietic system disease DOID:74 0 0.011