Mus musculus

101 known processes

E2f1

E2F transcription factor 1

(Aliases: mKIAA4009,E2F-1,KIAA4009)

E2f1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to dna damage stimulus GO:0006974 207 0.997
Human
dna metabolic process GO:0006259 303 0.995
Fly
g1 s transition of mitotic cell cycle GO:0000082 57 0.992
Human Mouse
regulation of cell cycle GO:0051726 281 0.992
regulation of cell cycle phase transition GO:1901987 77 0.978
Human
regulation of mitotic cell cycle phase transition GO:1901990 73 0.969
Human
negative regulation of cell cycle GO:0045786 123 0.941
negative regulation of cell cycle phase transition GO:1901988 48 0.934
regulation of mitotic cell cycle GO:0007346 126 0.932
Human
dna repair GO:0006281 107 0.925
dna endoreduplication GO:0042023 4 0.922
Fly
cell cycle g1 s phase transition GO:0044843 57 0.918
Human Mouse
negative regulation of mitotic cell cycle GO:0045930 58 0.901
mitotic cell cycle GO:0000278 195 0.885
Human Mouse
dna damage checkpoint GO:0000077 26 0.863
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.850
positive regulation of programmed cell death GO:0043068 218 0.833
Fly
dna integrity checkpoint GO:0031570 28 0.808
Human
apoptotic signaling pathway GO:0097190 306 0.788
cell cycle checkpoint GO:0000075 47 0.784
Human
positive regulation of apoptotic process GO:0043065 217 0.761
Fly
gland development GO:0048732 330 0.760
intrinsic apoptotic signaling pathway GO:0097193 132 0.756
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.737
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.732
regulation of cell cycle process GO:0010564 160 0.710
Human
double strand break repair GO:0006302 48 0.701
signal transduction by p53 class mediator GO:0072331 51 0.691
response to ionizing radiation GO:0010212 42 0.637
chromatin organization GO:0006325 206 0.634
mitotic cell cycle checkpoint GO:0007093 31 0.634
cell type specific apoptotic process GO:0097285 268 0.628
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.591
carbohydrate metabolic process GO:0005975 230 0.590
response to radiation GO:0009314 165 0.582
negative regulation of cell proliferation GO:0008285 296 0.560
response to light stimulus GO:0009416 135 0.546
dna biosynthetic process GO:0071897 22 0.546
mitotic cell cycle process GO:1903047 159 0.530
Human Mouse
dna recombination GO:0006310 92 0.525
anoikis GO:0043276 6 0.517
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.506
Human
gene silencing GO:0016458 38 0.476
cajal body organization GO:0030576 1 0.476
regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0000083 3 0.474
Human Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.470
regulation of cellular amine metabolic process GO:0033238 20 0.463
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.451
Human
regulation of anatomical structure size GO:0090066 178 0.447
Mouse
meiotic cell cycle process GO:1903046 77 0.407
protein ubiquitination GO:0016567 171 0.406
oogenesis GO:0048477 56 0.403
Fly
response to oxidative stress GO:0006979 123 0.398
dna replication GO:0006260 52 0.386
Fly
cellular amine metabolic process GO:0044106 44 0.381
chromosome segregation GO:0007059 48 0.380
cellular amino acid metabolic process GO:0006520 103 0.376
negative regulation of phosphorylation GO:0042326 166 0.370
humoral immune response GO:0006959 57 0.368
Fly
regulation of cellular component size GO:0032535 121 0.364
Mouse
regulation of cell size GO:0008361 72 0.360
Mouse
negative regulation of dna replication GO:0008156 4 0.356
ubiquitin dependent protein catabolic process GO:0006511 129 0.356
protein maturation GO:0051604 176 0.354
neural precursor cell proliferation GO:0061351 121 0.335
response to organonitrogen compound GO:0010243 246 0.335
negative regulation of phosphorus metabolic process GO:0010563 184 0.335
negative regulation of molecular function GO:0044092 258 0.331
mitotic sister chromatid cohesion GO:0007064 1 0.325
cellular response to growth factor stimulus GO:0071363 197 0.319
regulation of cell cycle g2 m phase transition GO:1902749 10 0.315
cell cycle arrest GO:0007050 37 0.314
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.311
positive regulation of defense response to bacterium GO:1900426 1 0.309
negative regulation of cell cycle process GO:0010948 69 0.308
positive regulation of cell death GO:0010942 224 0.305
Fly
germ cell development GO:0007281 185 0.303
Fly
regulation of cell cycle g1 s phase transition GO:1902806 35 0.295
Human
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.289
cellular response to oxidative stress GO:0034599 76 0.287
regulation of cellular catabolic process GO:0031329 242 0.285
positive regulation of cell development GO:0010720 237 0.279
Fly
response to growth factor GO:0070848 198 0.279
regulation of dna replication GO:0006275 17 0.278
spermatogenesis GO:0007283 284 0.277
mitotic g2 dna damage checkpoint GO:0007095 8 0.276
intra s dna damage checkpoint GO:0031573 4 0.272
regulation of g1 s transition of mitotic cell cycle GO:2000045 35 0.253
Human
male gamete generation GO:0048232 285 0.251
response to transforming growth factor beta GO:0071559 88 0.249
regulation of cohesin localization to chromatin GO:0071922 1 0.249
protein processing GO:0016485 163 0.248
muscle cell differentiation GO:0042692 261 0.245
regulation of protein kinase activity GO:0045859 232 0.241
organonitrogen compound biosynthetic process GO:1901566 192 0.239
regulation of cysteine type endopeptidase activity GO:2000116 65 0.234
regulation of neural precursor cell proliferation GO:2000177 70 0.229
modification dependent protein catabolic process GO:0019941 133 0.228
regulation of intracellular transport GO:0032386 159 0.226
cell cycle g2 m phase transition GO:0044839 20 0.225
cellular homeostasis GO:0019725 240 0.222
Mouse
negative regulation of kinase activity GO:0033673 81 0.221
regulation of cytoplasmic transport GO:1903649 112 0.220
negative regulation of phosphate metabolic process GO:0045936 184 0.219
cellular protein catabolic process GO:0044257 155 0.218
myeloid cell differentiation GO:0030099 233 0.209
response to heat GO:0009408 27 0.206
cellular ketone metabolic process GO:0042180 84 0.204
regulation of protein localization GO:0032880 231 0.204
meiosis i GO:0007127 60 0.203
nuclear division GO:0000280 158 0.202
stem cell proliferation GO:0072089 117 0.201
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.198
chromatin silencing GO:0006342 15 0.198
regulation of neuron apoptotic process GO:0043523 122 0.196
cellular response to external stimulus GO:0071496 88 0.195
nucleosome disassembly GO:0006337 1 0.194
meiotic cell cycle GO:0051321 122 0.194
protein catabolic process GO:0030163 221 0.193
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.192
cell fate commitment GO:0045165 210 0.190
regulation of endopeptidase activity GO:0052548 89 0.190
cohesin localization to chromatin GO:0071921 1 0.186
regulation of binding GO:0051098 111 0.186
regionalization GO:0003002 337 0.186
cellular response to organonitrogen compound GO:0071417 145 0.186
response to oxygen levels GO:0070482 62 0.185
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.185
macromolecule catabolic process GO:0009057 281 0.183
negative regulation of protein phosphorylation GO:0001933 126 0.180
rhythmic process GO:0048511 174 0.179
negative regulation of cell cycle g1 s phase transition GO:1902807 18 0.176
forebrain development GO:0030900 302 0.174
regulation of chromosome organization GO:0033044 83 0.174
covalent chromatin modification GO:0016569 163 0.173
erythrocyte differentiation GO:0030218 88 0.172
regulation of neuroblast proliferation GO:1902692 27 0.170
neural tube formation GO:0001841 108 0.167
cell division GO:0051301 120 0.166
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.166
positive regulation of organelle organization GO:0010638 128 0.165
chromatin modification GO:0016568 187 0.165
regulation of apoptotic signaling pathway GO:2001233 197 0.163
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.160
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 18 0.159
negative regulation of transferase activity GO:0051348 85 0.159
regulation of intracellular protein transport GO:0033157 82 0.159
regulation of hydrolase activity GO:0051336 246 0.157
cilium morphogenesis GO:0060271 102 0.156
Mouse
cellular response to nutrient levels GO:0031669 64 0.156
ossification GO:0001503 216 0.156
carbohydrate derivative biosynthetic process GO:1901137 183 0.153
negative regulation of immune system process GO:0002683 209 0.153
neuron apoptotic process GO:0051402 142 0.152
neural tube development GO:0021915 160 0.152
negative regulation of neural precursor cell proliferation GO:2000178 18 0.151
embryonic epithelial tube formation GO:0001838 130 0.150
positive regulation of histone methylation GO:0031062 16 0.148
homeostasis of number of cells GO:0048872 210 0.148
regulation of cell division GO:0051302 76 0.144
dna dependent dna replication GO:0006261 24 0.140
g2 m transition of mitotic cell cycle GO:0000086 20 0.138
mitotic g1 dna damage checkpoint GO:0031571 4 0.137
regulation of cellular amino acid metabolic process GO:0006521 5 0.137
regulation of peptidase activity GO:0052547 96 0.136
meiotic nuclear division GO:0007126 115 0.135
negative regulation of protein metabolic process GO:0051248 282 0.134
neuron death GO:0070997 154 0.134
regulation of stem cell proliferation GO:0072091 78 0.133
negative regulation of neuron death GO:1901215 98 0.132
signal transduction involved in dna damage checkpoint GO:0072422 3 0.131
base excision repair GO:0006284 9 0.131
primary neural tube formation GO:0014020 95 0.130
positive regulation of apoptotic signaling pathway GO:2001235 95 0.130
organelle fission GO:0048285 170 0.130
regulation of organelle organization GO:0033043 289 0.130
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.128
chromatin disassembly GO:0031498 1 0.128
axonogenesis GO:0007409 274 0.127
cellular response to peptide hormone stimulus GO:0071375 92 0.127
regulation of protein targeting GO:1903533 61 0.126
positive regulation of cell cycle GO:0045787 92 0.123
apoptotic process involved in development GO:1902742 28 0.122
Fly
carbohydrate homeostasis GO:0033500 128 0.122
response to peptide hormone GO:0043434 127 0.122
peptidyl amino acid modification GO:0018193 336 0.122
response to peptide GO:1901652 136 0.121
cytoplasmic transport GO:0016482 234 0.121
organic cyclic compound catabolic process GO:1901361 295 0.120
regulation of transcription regulatory region dna binding GO:2000677 9 0.120
positive regulation of endopeptidase activity GO:0010950 43 0.117
positive regulation of multi organism process GO:0043902 26 0.117
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.113
mitotic nuclear division GO:0007067 48 0.112
positive regulation of proteolysis GO:0045862 85 0.111
response to reactive oxygen species GO:0000302 56 0.110
antibacterial peptide biosynthetic process GO:0002780 2 0.110
mitotic chromosome condensation GO:0007076 1 0.109
regulation of secretion GO:0051046 274 0.109
negative regulation of protein modification process GO:0031400 163 0.107
oocyte differentiation GO:0009994 35 0.107
pallium development GO:0021543 120 0.106
b cell activation GO:0042113 161 0.106
recombinational repair GO:0000725 21 0.106
maintenance of location GO:0051235 89 0.106
cellular response to insulin stimulus GO:0032869 78 0.106
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.105
regulation of actin cytoskeleton organization GO:0032956 84 0.105
regulation of leukocyte apoptotic process GO:2000106 56 0.105
positive regulation of keratinocyte proliferation GO:0010838 4 0.105
nuclear transport GO:0051169 139 0.105
dna dependent dna replication maintenance of fidelity GO:0045005 3 0.104
intracellular protein transport GO:0006886 204 0.104
negative regulation of growth GO:0045926 99 0.103
cellular macromolecule catabolic process GO:0044265 206 0.103
telencephalon development GO:0021537 186 0.103
regulation of cytokine production GO:0001817 266 0.103
modification dependent macromolecule catabolic process GO:0043632 133 0.102
regulation of defense response to bacterium GO:1900424 3 0.102
regulation of transferase activity GO:0051338 263 0.102
negative regulation of intracellular signal transduction GO:1902532 167 0.101
anatomical structure homeostasis GO:0060249 145 0.101
negative regulation of gene expression epigenetic GO:0045814 15 0.101
response to oxygen radical GO:0000305 16 0.101
regulation of multi organism process GO:0043900 111 0.100
Fly
striated muscle tissue development GO:0014706 293 0.100
single organism nuclear import GO:1902593 95 0.100
cellular protein complex assembly GO:0043623 116 0.099
antimicrobial peptide production GO:0002775 2 0.099
regulation of protein catabolic process GO:0042176 108 0.099
protein modification by small protein conjugation GO:0032446 187 0.099
glucose homeostasis GO:0042593 128 0.098
negative regulation of cellular amine metabolic process GO:0033239 1 0.098
heterocycle catabolic process GO:0046700 280 0.098
response to hypoxia GO:0001666 58 0.097
regulation of cell motility GO:2000145 236 0.097
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.096
methylation GO:0032259 134 0.096
purine ribonucleotide metabolic process GO:0009150 290 0.095
positive regulation of chromosome segregation GO:0051984 4 0.095
mitochondrion organization GO:0007005 134 0.095
blood vessel morphogenesis GO:0048514 285 0.095
cell adhesion GO:0007155 329 0.095
embryonic organ morphogenesis GO:0048562 276 0.095
angiogenesis GO:0001525 201 0.095
regulation of exit from mitosis GO:0007096 1 0.094
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.094
positive regulation of chromosome organization GO:2001252 33 0.094
production of molecular mediator of immune response GO:0002440 103 0.094
skeletal system development GO:0001501 356 0.092
purine containing compound metabolic process GO:0072521 311 0.092
gliogenesis GO:0042063 141 0.092
positive regulation of cellular catabolic process GO:0031331 148 0.092
antimicrobial peptide biosynthetic process GO:0002777 2 0.089
positive regulation of peptidase activity GO:0010952 49 0.089
negative regulation of hydrolase activity GO:0051346 71 0.088
dendrite development GO:0016358 115 0.088
Fly
organelle assembly GO:0070925 177 0.087
Mouse
tube formation GO:0035148 140 0.086
response to superoxide GO:0000303 16 0.086
female gamete generation GO:0007292 74 0.086
Fly
myeloid cell homeostasis GO:0002262 114 0.085
macromolecule methylation GO:0043414 120 0.085
oxidation reduction process GO:0055114 342 0.084
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.084
regulation of mast cell differentiation GO:0060375 3 0.083
regulation of kinase activity GO:0043549 249 0.083
glial cell apoptotic process GO:0034349 3 0.083
cellular response to extracellular stimulus GO:0031668 81 0.083
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.082
double strand break repair via homologous recombination GO:0000724 21 0.081
cellular response to peptide GO:1901653 92 0.081
apoptotic mitochondrial changes GO:0008637 48 0.080
regulation of synaptic plasticity GO:0048167 87 0.079
multicellular organism growth GO:0035264 161 0.079
regulation of neuron death GO:1901214 134 0.079
cellular carbohydrate metabolic process GO:0044262 119 0.079
regulation of protein import into nucleus GO:0042306 52 0.078
purine ribonucleoside metabolic process GO:0046128 241 0.078
negative regulation of cellular protein metabolic process GO:0032269 247 0.078
t cell activation GO:0042110 289 0.078
response to inorganic substance GO:0010035 96 0.078
regulation of protein serine threonine kinase activity GO:0071900 157 0.077
positive regulation of reproductive process GO:2000243 19 0.077
Fly
lymphocyte differentiation GO:0030098 242 0.077
protein localization to organelle GO:0033365 185 0.076
regulation of histone modification GO:0031056 56 0.076
positive regulation of mitotic cell cycle GO:0045931 41 0.076
protein polyubiquitination GO:0000209 33 0.076
negative regulation of stem cell proliferation GO:2000647 12 0.076
positive regulation of protein modification process GO:0031401 299 0.076
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.076
regulation of proteolysis GO:0030162 164 0.075
locomotory behavior GO:0007626 195 0.075
regulation of transcription by chromatin organization GO:0034401 0 0.075
cilium assembly GO:0042384 81 0.075
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 40 0.075
positive regulation of hydrolase activity GO:0051345 148 0.074
negative regulation of neuroblast proliferation GO:0007406 7 0.074
nucleoside phosphate catabolic process GO:1901292 222 0.074
g2 dna damage checkpoint GO:0031572 8 0.073
regulation of protein transport GO:0051223 163 0.073
response to organic cyclic compound GO:0014070 198 0.073
negative regulation of nervous system development GO:0051961 156 0.072
regulation of cellular component biogenesis GO:0044087 181 0.072
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.071
mitotic cell cycle arrest GO:0071850 4 0.071
ribonucleoside metabolic process GO:0009119 245 0.071
liver development GO:0001889 66 0.071
cellular response to oxygen radical GO:0071450 14 0.070
multicellular organismal homeostasis GO:0048871 164 0.069
response to decreased oxygen levels GO:0036293 59 0.069
leukocyte differentiation GO:0002521 342 0.069
release of cytochrome c from mitochondria GO:0001836 23 0.069
activation of cysteine type endopeptidase activity GO:0097202 27 0.069
organophosphate biosynthetic process GO:0090407 122 0.069
regulation of autophagy GO:0010506 30 0.068
histone lysine methylation GO:0034968 50 0.068
cellular component assembly involved in morphogenesis GO:0010927 139 0.068
Mouse
dna conformation change GO:0071103 37 0.067
cell aging GO:0007569 35 0.067
small gtpase mediated signal transduction GO:0007264 97 0.067
macromolecule glycosylation GO:0043413 55 0.066
regulation of nucleocytoplasmic transport GO:0046822 73 0.066
regulation of protein localization to nucleus GO:1900180 60 0.065
purine ribonucleoside catabolic process GO:0046130 205 0.065
gonad development GO:0008406 141 0.065
actin cytoskeleton organization GO:0030036 220 0.065
positive regulation of antimicrobial peptide production GO:0002225 1 0.065
organonitrogen compound catabolic process GO:1901565 264 0.065
glycosylation GO:0070085 62 0.065
microtubule cytoskeleton organization involved in mitosis GO:1902850 4 0.064
regulation of proteasomal protein catabolic process GO:0061136 46 0.064
positive regulation of transcription regulatory region dna binding GO:2000679 1 0.064
nucleocytoplasmic transport GO:0006913 139 0.064
response to temperature stimulus GO:0009266 55 0.063
hepaticobiliary system development GO:0061008 67 0.063
regulation of nuclear cell cycle dna replication GO:0033262 2 0.063
carbohydrate derivative catabolic process GO:1901136 231 0.063
developmental cell growth GO:0048588 84 0.062
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.062
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.062
cell maturation GO:0048469 127 0.062
lymphocyte apoptotic process GO:0070227 54 0.062
cardiocyte differentiation GO:0035051 87 0.062
rho protein signal transduction GO:0007266 32 0.061
response to purine containing compound GO:0014074 28 0.061
actin filament organization GO:0007015 113 0.060
negative regulation of cell development GO:0010721 169 0.059
positive regulation of cellular amine metabolic process GO:0033240 5 0.059
nucleotide excision repair GO:0006289 13 0.059
protein import into nucleus GO:0006606 95 0.059
neural tube closure GO:0001843 90 0.058
regulation of chromatin modification GO:1903308 57 0.058
muscle tissue development GO:0060537 308 0.058
Fly
defense response to other organism GO:0098542 197 0.058
monosaccharide metabolic process GO:0005996 106 0.058
organic hydroxy compound metabolic process GO:1901615 203 0.057
male meiosis GO:0007140 37 0.057
signal transduction involved in cell cycle checkpoint GO:0072395 3 0.057
regulation of establishment of protein localization GO:0070201 181 0.057
glycosyl compound metabolic process GO:1901657 246 0.057
ribonucleotide catabolic process GO:0009261 208 0.057
protein glycosylation GO:0006486 55 0.057
protein targeting GO:0006605 143 0.057
extrinsic apoptotic signaling pathway GO:0097191 126 0.056
glucose metabolic process GO:0006006 92 0.056
ribonucleoside catabolic process GO:0042454 206 0.056
response to uv GO:0009411 44 0.056
myeloid leukocyte differentiation GO:0002573 119 0.056
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.055
peptidyl tyrosine modification GO:0018212 145 0.055
developmental growth involved in morphogenesis GO:0060560 138 0.055
purine containing compound catabolic process GO:0072523 213 0.055
negative regulation of cell size GO:0045792 3 0.055
regulation of dna binding GO:0051101 39 0.054
positive regulation of exit from mitosis GO:0031536 1 0.054
epithelial tube formation GO:0072175 130 0.054
innate immune response GO:0045087 157 0.054
genetic imprinting GO:0071514 27 0.054
reciprocal dna recombination GO:0035825 16 0.054
regulation of cellular protein catabolic process GO:1903362 61 0.054
regulation of smad protein import into nucleus GO:0060390 3 0.054
hexose metabolic process GO:0019318 98 0.054
purine nucleoside metabolic process GO:0042278 241 0.053
intestinal epithelial structure maintenance GO:0060729 4 0.053
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.053
positive regulation of histone modification GO:0031058 28 0.052
nucleoside catabolic process GO:0009164 206 0.052
nucleoside triphosphate metabolic process GO:0009141 230 0.052
zymogen activation GO:0031638 41 0.052
response to insulin GO:0032868 100 0.051
metaphase plate congression GO:0051310 2 0.051
b cell differentiation GO:0030183 78 0.051
actomyosin structure organization GO:0031032 56 0.051
sensory organ morphogenesis GO:0090596 242 0.051
antibacterial peptide production GO:0002778 2 0.051
auditory receptor cell fate determination GO:0042668 3 0.050
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.050
cellular response to radiation GO:0071478 28 0.050
cytokine production GO:0001816 319 0.050
ribonucleotide metabolic process GO:0009259 291 0.050
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.050
epithelial tube morphogenesis GO:0060562 303 0.050
ras protein signal transduction GO:0007265 77 0.050
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.049
cellular response to acid chemical GO:0071229 68 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.049
positive regulation of antimicrobial humoral response GO:0002760 2 0.048
regulation of response to biotic stimulus GO:0002831 38 0.048
protein polymerization GO:0051258 57 0.048
trophoblast giant cell differentiation GO:0060707 15 0.048
positive regulation of cell division GO:0051781 31 0.048
neuroblast proliferation GO:0007405 49 0.048
positive regulation of mitotic cell cycle phase transition GO:1901992 17 0.048
regulation of lymphocyte apoptotic process GO:0070228 41 0.047
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.047
purine ribonucleotide catabolic process GO:0009154 208 0.046
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 3 0.046
signal transduction involved in mitotic dna damage checkpoint GO:1902402 3 0.046
regulation of protein stability GO:0031647 52 0.046
hormone secretion GO:0046879 128 0.045
cleavage furrow formation GO:0036089 2 0.045
antimicrobial humoral response GO:0019730 11 0.045
Fly
aromatic compound catabolic process GO:0019439 286 0.044
peptidyl tyrosine phosphorylation GO:0018108 143 0.044
negative regulation of cell aging GO:0090344 5 0.044
signal transduction in absence of ligand GO:0038034 55 0.044
developmental programmed cell death GO:0010623 41 0.044
Fly
protein localization to chromatin GO:0071168 3 0.044
circadian rhythm GO:0007623 114 0.044
epithelial cell development GO:0002064 159 0.044
Mouse
regulation of cytoskeleton organization GO:0051493 122 0.044
nucleoside metabolic process GO:0009116 246 0.044
ovulation cycle GO:0042698 59 0.044
protein localization to chromosome centromeric region GO:0071459 1 0.044
regulation of mitotic sister chromatid segregation GO:0033047 12 0.044
histone modification GO:0016570 159 0.043
hematopoietic progenitor cell differentiation GO:0002244 143 0.043
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.043
cellular response to superoxide GO:0071451 14 0.043
negative regulation of apoptotic signaling pathway GO:2001234 104 0.043
megakaryocyte differentiation GO:0030219 26 0.042
regulation of chromatin organization GO:1902275 57 0.042
regulation of mitosis GO:0007088 29 0.042
positive regulation of protein ubiquitination GO:0031398 27 0.042
metaphase anaphase transition of mitotic cell cycle GO:0007091 9 0.042
negative regulation of cell activation GO:0050866 111 0.042
extracellular structure organization GO:0043062 148 0.041
cation transport GO:0006812 399 0.041
epithelial cell proliferation GO:0050673 174 0.041
negative regulation of leukocyte proliferation GO:0070664 46 0.041
positive regulation of histone h3 k9 methylation GO:0051574 4 0.041
nucleobase containing small molecule metabolic process GO:0055086 352 0.040
nucleotide metabolic process GO:0009117 332 0.040
regulation of cellular response to growth factor stimulus GO:0090287 82 0.040
nucleoside phosphate metabolic process GO:0006753 338 0.040
stem cell differentiation GO:0048863 268 0.040
regulation of antibacterial peptide production GO:0002786 1 0.040
negative regulation of t cell proliferation GO:0042130 38 0.040
purine nucleoside catabolic process GO:0006152 205 0.040
cellularization GO:0007349 1 0.040
mitotic sister chromatid separation GO:0051306 9 0.040
dna packaging GO:0006323 30 0.040
amine metabolic process GO:0009308 45 0.040
cellular response to cytokine stimulus GO:0071345 189 0.040
nuclear dna replication GO:0033260 3 0.040
regulation of chromatin silencing GO:0031935 2 0.040
cell growth GO:0016049 130 0.039
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.039
regulation of protein ubiquitination GO:0031396 52 0.038
reactive oxygen species metabolic process GO:0072593 84 0.038
negative regulation of lymphocyte proliferation GO:0050672 45 0.038
regulation of lipid metabolic process GO:0019216 118 0.038
notch signaling pathway GO:0007219 71 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
histone acetylation GO:0016573 41 0.037
regulation of reproductive process GO:2000241 66 0.037
Fly
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.037
regulation of antimicrobial humoral response GO:0002759 3 0.037
camera type eye development GO:0043010 266 0.037
cellular response to hormone stimulus GO:0032870 150 0.037
tube closure GO:0060606 91 0.037

E2f1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.419
cancer DOID:162 0 0.130
organ system cancer DOID:0050686 0 0.104
thoracic cancer DOID:5093 0 0.064
immune system cancer DOID:0060083 0 0.060
gastrointestinal system cancer DOID:3119 0 0.055
breast cancer DOID:1612 0 0.047
large intestine cancer DOID:5672 0 0.044
intestinal cancer DOID:10155 0 0.044
disease of metabolism DOID:0014667 0 0.037
inherited metabolic disorder DOID:655 0 0.037
urinary system cancer DOID:3996 0 0.037