Mus musculus

0 known processes

Eif1a

eukaryotic translation initiation factor 1A

(Aliases: eIF-1A,C76390,Ef1a,Eftu,Eif4c)

Eif1a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
maturation of ssu rrna GO:0030490 1 0.346
carbohydrate derivative biosynthetic process GO:1901137 183 0.253
activation of adenylate cyclase activity GO:0007190 4 0.187
amine metabolic process GO:0009308 45 0.177
ribosomal small subunit biogenesis GO:0042274 4 0.175
establishment of protein localization to organelle GO:0072594 118 0.159
regulation of kinase activity GO:0043549 249 0.148
organophosphate biosynthetic process GO:0090407 122 0.132
regulation of myeloid leukocyte differentiation GO:0002761 58 0.126
mapk cascade GO:0000165 281 0.122
regulation of cellular response to growth factor stimulus GO:0090287 82 0.121
heterocycle catabolic process GO:0046700 280 0.109
translational initiation GO:0006413 24 0.104
urogenital system development GO:0001655 261 0.098
myeloid leukocyte differentiation GO:0002573 119 0.097
regulation of cellular component size GO:0032535 121 0.094
cellular nitrogen compound catabolic process GO:0044270 280 0.091
myeloid cell differentiation GO:0030099 233 0.091
positive regulation of leukocyte differentiation GO:1902107 86 0.091
nucleoside phosphate metabolic process GO:0006753 338 0.090
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.086
ribosome biogenesis GO:0042254 20 0.084
regulation of cellular amine metabolic process GO:0033238 20 0.077
regulation of nucleotide biosynthetic process GO:0030808 34 0.071
cellular response to cytokine stimulus GO:0071345 189 0.068
appendage morphogenesis GO:0035107 149 0.066
nucleotide biosynthetic process GO:0009165 78 0.062
regulation of neuron differentiation GO:0045664 281 0.062
regulation of mapk cascade GO:0043408 248 0.061
epithelial tube morphogenesis GO:0060562 303 0.060
negative regulation of molecular function GO:0044092 258 0.060
cytoplasmic transport GO:0016482 234 0.060
camera type eye development GO:0043010 266 0.059
nucleobase containing small molecule metabolic process GO:0055086 352 0.059
cell type specific apoptotic process GO:0097285 268 0.058
forebrain development GO:0030900 302 0.058
aromatic compound catabolic process GO:0019439 286 0.057
nucleoside phosphate biosynthetic process GO:1901293 79 0.056
cellular amine metabolic process GO:0044106 44 0.055
regulation of leukocyte differentiation GO:1902105 159 0.052
leukocyte differentiation GO:0002521 342 0.051
protein import GO:0017038 101 0.050
kidney development GO:0001822 213 0.050
endonucleolytic cleavage involved in rrna processing GO:0000478 1 0.049
glial cell development GO:0021782 54 0.047
regulation of cell migration GO:0030334 219 0.047
intracellular sterol transport GO:0032366 3 0.047
regulation of cell motility GO:2000145 236 0.044
blood vessel morphogenesis GO:0048514 285 0.044
cellular amino acid metabolic process GO:0006520 103 0.043
determination of heart left right asymmetry GO:0061371 48 0.042
transmembrane transport GO:0055085 412 0.041
single organism nuclear import GO:1902593 95 0.041
organonitrogen compound biosynthetic process GO:1901566 192 0.040
regulation of cellular ketone metabolic process GO:0010565 66 0.039
actin filament organization GO:0007015 113 0.039
regulation of protein localization GO:0032880 231 0.039
purine ribonucleotide metabolic process GO:0009150 290 0.038
ribose phosphate metabolic process GO:0019693 291 0.036
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.036
nucleoside phosphate catabolic process GO:1901292 222 0.036
lipid biosynthetic process GO:0008610 179 0.036
multicellular organismal signaling GO:0035637 91 0.036
purine nucleotide biosynthetic process GO:0006164 65 0.035
intracellular protein transport GO:0006886 204 0.034
cell maturation GO:0048469 127 0.034
regulation of cyclase activity GO:0031279 13 0.034
translation GO:0006412 93 0.033
nucleotide metabolic process GO:0009117 332 0.033
glycoprotein metabolic process GO:0009100 116 0.033
regulation of anatomical structure size GO:0090066 178 0.033
neuronal action potential GO:0019228 54 0.033
regulation of cell projection organization GO:0031344 206 0.032
small gtpase mediated signal transduction GO:0007264 97 0.032
protein acylation GO:0043543 64 0.031
cyclic purine nucleotide metabolic process GO:0052652 43 0.031
response to acid chemical GO:0001101 111 0.031
ribonucleoprotein complex subunit organization GO:0071826 28 0.031
regulation of transferase activity GO:0051338 263 0.031
purine nucleotide metabolic process GO:0006163 302 0.031
ribonucleoside triphosphate metabolic process GO:0009199 220 0.030
response to light stimulus GO:0009416 135 0.030
negative regulation of tyrosine phosphorylation of stat3 protein GO:0042518 1 0.030
lipid localization GO:0010876 126 0.030
regulation of myeloid cell differentiation GO:0045637 96 0.030
response to purine containing compound GO:0014074 28 0.030
cleavage involved in rrna processing GO:0000469 1 0.029
negative regulation of growth GO:0045926 99 0.029
carbohydrate derivative catabolic process GO:1901136 231 0.029
gliogenesis GO:0042063 141 0.028
glycosyl compound metabolic process GO:1901657 246 0.028
action potential GO:0001508 78 0.028
regulation of cell growth GO:0001558 91 0.028
positive regulation of rac protein signal transduction GO:0035022 1 0.028
glial cell differentiation GO:0010001 131 0.028
regulation of cellular amino acid metabolic process GO:0006521 5 0.027
protein localization to organelle GO:0033365 185 0.027
ubiquitin dependent protein catabolic process GO:0006511 129 0.027
ribonucleotide metabolic process GO:0009259 291 0.027
negative regulation of phosphorus metabolic process GO:0010563 184 0.027
glycosyl compound catabolic process GO:1901658 206 0.027
cellular response to interleukin 15 GO:0071350 2 0.026
negative regulation of cellular amine metabolic process GO:0033239 1 0.026
central nervous system neuron differentiation GO:0021953 162 0.026
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.026
protein targeting GO:0006605 143 0.026
regulation of epithelial cell proliferation GO:0050678 141 0.026
ribonucleotide biosynthetic process GO:0009260 59 0.026
regulation of secretion by cell GO:1903530 249 0.026
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.025
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.025
regulation of exit from mitosis GO:0007096 1 0.025
circulatory system process GO:0003013 197 0.025
protein import into nucleus GO:0006606 95 0.025
ribonucleoside metabolic process GO:0009119 245 0.024
camp biosynthetic process GO:0006171 31 0.024
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.024
positive regulation of cell development GO:0010720 237 0.024
positive regulation of nucleotide metabolic process GO:0045981 114 0.023
positive regulation of purine nucleotide biosynthetic process GO:1900373 26 0.023
regulation of neuron projection development GO:0010975 169 0.023
immune response activating signal transduction GO:0002757 116 0.023
epithelial cell proliferation GO:0050673 174 0.023
polyamine transport GO:0015846 5 0.023
compound eye development GO:0048749 1 0.023
neuron death GO:0070997 154 0.023
retina development in camera type eye GO:0060041 119 0.023
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.023
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.022
nucleoside metabolic process GO:0009116 246 0.022
regulation of osteoclast differentiation GO:0045670 36 0.022
t cell differentiation GO:0030217 174 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
negative regulation of cell motility GO:2000146 61 0.022
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.022
transmission of nerve impulse GO:0019226 76 0.022
rna processing GO:0006396 105 0.021
morphogenesis of a branching structure GO:0001763 203 0.021
purine containing compound biosynthetic process GO:0072522 70 0.021
histone acetylation GO:0016573 41 0.021
negative regulation of cellular response to growth factor stimulus GO:0090288 46 0.021
organism emergence from protective structure GO:0071684 4 0.021
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.021
striated muscle tissue development GO:0014706 293 0.021
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.021
negative regulation of pathway restricted smad protein phosphorylation GO:0060394 1 0.020
mesonephros development GO:0001823 97 0.020
tissue homeostasis GO:0001894 115 0.020
regulation of secretion GO:0051046 274 0.020
skeletal system development GO:0001501 356 0.020
response to growth factor GO:0070848 198 0.020
regulation of neuron apoptotic process GO:0043523 122 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.019
organic cyclic compound catabolic process GO:1901361 295 0.019
t cell activation GO:0042110 289 0.019
antigen receptor mediated signaling pathway GO:0050851 64 0.019
negative regulation of tyrosine phosphorylation of stat protein GO:0042532 3 0.019
regulation of lymphocyte activation GO:0051249 240 0.019
stem cell differentiation GO:0048863 268 0.019
negative regulation of cellular protein metabolic process GO:0032269 247 0.019
ribonucleoprotein complex disassembly GO:0032988 3 0.019
purine ribonucleotide biosynthetic process GO:0009152 59 0.019
g protein coupled receptor signaling pathway GO:0007186 243 0.019
cyclic nucleotide biosynthetic process GO:0009190 44 0.019
cellular response to lipid GO:0071396 145 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
pyrimidine nucleoside metabolic process GO:0006213 2 0.019
negative regulation of protein phosphorylation GO:0001933 126 0.018
negative regulation of cell migration GO:0030336 59 0.018
lipid transport GO:0006869 98 0.018
regulation of purine nucleotide metabolic process GO:1900542 169 0.018
ossification GO:0001503 216 0.018
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.018
innate immune response GO:0045087 157 0.018
regulation of transcription from rna polymerase i promoter GO:0006356 6 0.018
peptidyl lysine acetylation GO:0018394 45 0.018
methylation GO:0032259 134 0.018
protein modification by small protein conjugation or removal GO:0070647 207 0.017
carbohydrate homeostasis GO:0033500 128 0.017
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.017
purine nucleoside catabolic process GO:0006152 205 0.017
lung development GO:0030324 164 0.017
regulation of body fluid levels GO:0050878 162 0.017
b cell activation GO:0042113 161 0.016
negative regulation of phosphorylation GO:0042326 166 0.016
morphogenesis of a branching epithelium GO:0061138 193 0.016
purine containing compound catabolic process GO:0072523 213 0.016
purine containing compound metabolic process GO:0072521 311 0.016
dna metabolic process GO:0006259 303 0.016
heart morphogenesis GO:0003007 178 0.016
purine ribonucleoside catabolic process GO:0046130 205 0.016
embryonic organ morphogenesis GO:0048562 276 0.016
negative regulation of protein modification process GO:0031400 163 0.016
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.016
modification dependent macromolecule catabolic process GO:0043632 133 0.016
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.016
cellular ketone metabolic process GO:0042180 84 0.016
cellular lipid metabolic process GO:0044255 323 0.016
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 8 0.015
immune response regulating signaling pathway GO:0002764 125 0.015
cell division GO:0051301 120 0.015
photoreceptor cell development GO:0042461 40 0.015
t cell receptor signaling pathway GO:0050852 46 0.015
regionalization GO:0003002 337 0.015
organic hydroxy compound transport GO:0015850 93 0.015
coagulation GO:0050817 78 0.015
positive regulation of secretion by cell GO:1903532 114 0.015
multicellular organismal homeostasis GO:0048871 164 0.015
regulation of membrane potential GO:0042391 192 0.015
ribonucleoprotein complex localization GO:0071166 1 0.015
hatching GO:0035188 4 0.014
regulation of hormone levels GO:0010817 211 0.014
toxin transport GO:1901998 38 0.014
neuron apoptotic process GO:0051402 142 0.014
response to tumor necrosis factor GO:0034612 26 0.014
nucleoside triphosphate catabolic process GO:0009143 205 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
ras protein signal transduction GO:0007265 77 0.014
intracellular lipid transport GO:0032365 3 0.014
ribose phosphate biosynthetic process GO:0046390 59 0.014
regulation of cytokine production GO:0001817 266 0.014
axon ensheathment GO:0008366 76 0.014
regulation of camp metabolic process GO:0030814 30 0.014
rrna processing GO:0006364 10 0.014
nucleoside catabolic process GO:0009164 206 0.014
positive regulation of nervous system development GO:0051962 221 0.014
regulation of cell size GO:0008361 72 0.014
regulation of chemotaxis GO:0050920 53 0.013
positive regulation of cellular respiration GO:1901857 3 0.013
positive regulation of hydrolase activity GO:0051345 148 0.013
respiratory tube development GO:0030323 167 0.013
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.013
cell growth GO:0016049 130 0.013
regulation of t cell differentiation GO:0045580 83 0.013
cardiac chamber morphogenesis GO:0003206 93 0.013
rna 5 end processing GO:0000966 1 0.013
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.013
developmental growth involved in morphogenesis GO:0060560 138 0.013
camp metabolic process GO:0046058 40 0.013
purine nucleoside metabolic process GO:0042278 241 0.013
peripheral nervous system neuron axonogenesis GO:0048936 3 0.013
polyamine biosynthetic process GO:0006596 2 0.013
organelle disassembly GO:1903008 2 0.013
guanosine containing compound catabolic process GO:1901069 144 0.013
ribonucleoside triphosphate catabolic process GO:0009203 199 0.013
regulation of platelet derived growth factor receptor beta signaling pathway GO:2000586 2 0.013
gland development GO:0048732 330 0.012
dephosphorylation GO:0016311 129 0.012
developmental maturation GO:0021700 193 0.012
nucleoside triphosphate metabolic process GO:0009141 230 0.012
negative regulation of nervous system development GO:0051961 156 0.012
positive regulation of mapk cascade GO:0043410 170 0.012
embryonic skeletal system development GO:0048706 120 0.012
limb morphogenesis GO:0035108 149 0.012
negative regulation of binding GO:0051100 39 0.012
cellular response to growth factor stimulus GO:0071363 197 0.012
response to organic cyclic compound GO:0014070 198 0.012
anatomical structure homeostasis GO:0060249 145 0.012
response to alkaloid GO:0043279 34 0.012
positive regulation of camp metabolic process GO:0030816 19 0.012
regulation of system process GO:0044057 200 0.012
negative regulation of vascular endothelial growth factor receptor signaling pathway GO:0030948 6 0.012
carbohydrate metabolic process GO:0005975 230 0.012
organelle localization GO:0051640 179 0.012
negative regulation of lymphocyte activation GO:0051250 91 0.012
cellular response to acid chemical GO:0071229 68 0.012
cytokine production GO:0001816 319 0.012
purine ribonucleoside metabolic process GO:0046128 241 0.011
rap protein signal transduction GO:0032486 3 0.011
organophosphate catabolic process GO:0046434 232 0.011
small molecule biosynthetic process GO:0044283 132 0.011
establishment of organelle localization GO:0051656 122 0.011
response to organonitrogen compound GO:0010243 246 0.011
negative regulation of platelet derived growth factor receptor beta signaling pathway GO:2000587 2 0.011
peptidyl lysine modification GO:0018205 77 0.011
negative regulation of t cell activation GO:0050868 65 0.011
peptidyl tyrosine modification GO:0018212 145 0.011
guanosine containing compound metabolic process GO:1901068 144 0.011
development of primary sexual characteristics GO:0045137 143 0.011
positive regulation of transcription by galactose GO:0000411 1 0.011
neural retina development GO:0003407 41 0.011
regulation of t cell activation GO:0050863 170 0.011
cellular metal ion homeostasis GO:0006875 151 0.011
macromolecule methylation GO:0043414 120 0.011
homeostasis of number of cells GO:0048872 210 0.011
regulation of binding GO:0051098 111 0.011
renal system development GO:0072001 225 0.011
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.011
peptidyl amino acid modification GO:0018193 336 0.011
body morphogenesis GO:0010171 45 0.011
response to inorganic substance GO:0010035 96 0.011
inflammatory response GO:0006954 244 0.011
regulation of protein catabolic process GO:0042176 108 0.011
regulation of reproductive process GO:2000241 66 0.010
regulation of proteolysis GO:0030162 164 0.010
regulation of cyclic nucleotide biosynthetic process GO:0030802 31 0.010
negative regulation of leukocyte differentiation GO:1902106 51 0.010
glucose homeostasis GO:0042593 128 0.010
cation homeostasis GO:0055080 212 0.010
negative regulation of cell proliferation GO:0008285 296 0.010
primary neural tube formation GO:0014020 95 0.010
negative regulation of protein metabolic process GO:0051248 282 0.010
regulation of hydrolase activity GO:0051336 246 0.010
cytokine mediated signaling pathway GO:0019221 115 0.010

Eif1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
large intestine cancer DOID:5672 0 0.051
cancer DOID:162 0 0.051
organ system cancer DOID:0050686 0 0.051
intestinal cancer DOID:10155 0 0.051
colon cancer DOID:219 0 0.051
gastrointestinal system cancer DOID:3119 0 0.051
colorectal cancer DOID:9256 0 0.051
disease of cellular proliferation DOID:14566 0 0.051
disease of metabolism DOID:0014667 0 0.032
inherited metabolic disorder DOID:655 0 0.032