Mus musculus

141 known processes

Fech

ferrochelatase

(Aliases: fch,Fcl,AI894116)

Fech biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cofactor biosynthetic process GO:0051188 41 0.571
myeloid cell differentiation GO:0030099 233 0.340
porphyrin containing compound biosynthetic process GO:0006779 16 0.305
membrane organization GO:0061024 245 0.291
organonitrogen compound biosynthetic process GO:1901566 192 0.282
tetrapyrrole metabolic process GO:0033013 22 0.263
plasma membrane organization GO:0007009 90 0.224
axonogenesis GO:0007409 274 0.212
porphyrin containing compound metabolic process GO:0006778 22 0.196
erythrocyte differentiation GO:0030218 88 0.193
endomembrane system organization GO:0010256 147 0.178
neuron projection guidance GO:0097485 141 0.157
protein localization to membrane GO:0072657 108 0.129
cellular amino acid metabolic process GO:0006520 103 0.126
protein localization to plasma membrane GO:0072659 57 0.117
chemotaxis GO:0006935 247 0.112
axon guidance GO:0007411 141 0.105
homeostasis of number of cells GO:0048872 210 0.100
regulation of transferase activity GO:0051338 263 0.100
sulfur compound biosynthetic process GO:0044272 37 0.099
cellular ketone metabolic process GO:0042180 84 0.081
hindbrain development GO:0030902 128 0.069
intracellular protein transport GO:0006886 204 0.069
tetrapyrrole biosynthetic process GO:0033014 16 0.068
response to radiation GO:0009314 165 0.067
iron ion homeostasis GO:0055072 36 0.067
amp metabolic process GO:0046033 4 0.065
single organism nuclear import GO:1902593 95 0.062
glycerolipid metabolic process GO:0046486 122 0.061
myeloid cell homeostasis GO:0002262 114 0.060
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.055
negative regulation of protein metabolic process GO:0051248 282 0.055
regulation of membrane potential GO:0042391 192 0.054
protein catabolic process GO:0030163 221 0.053
cellular component assembly involved in morphogenesis GO:0010927 139 0.053
cellular macromolecule catabolic process GO:0044265 206 0.053
regulation of apoptotic signaling pathway GO:2001233 197 0.053
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 12 0.051
protein targeting to plasma membrane GO:0072661 7 0.051
multicellular organism growth GO:0035264 161 0.050
protein ubiquitination GO:0016567 171 0.050
dephosphorylation GO:0016311 129 0.049
protein modification by small protein conjugation or removal GO:0070647 207 0.049
nuclear division GO:0000280 158 0.049
monocarboxylic acid metabolic process GO:0032787 191 0.046
metencephalon development GO:0022037 89 0.046
response to oxidative stress GO:0006979 123 0.046
regulation of protein serine threonine kinase activity GO:0071900 157 0.045
regulation of cellular amino acid metabolic process GO:0006521 5 0.045
transmembrane transport GO:0055085 412 0.045
cellular ion homeostasis GO:0006873 165 0.044
organic acid biosynthetic process GO:0016053 86 0.043
alcohol metabolic process GO:0006066 116 0.042
positive regulation of potassium ion transport GO:0043268 3 0.042
regulation of cellular ketone metabolic process GO:0010565 66 0.042
defecation GO:0030421 1 0.040
cellular lipid metabolic process GO:0044255 323 0.040
transition metal ion homeostasis GO:0055076 54 0.039
ras protein signal transduction GO:0007265 77 0.039
positive regulation of growth GO:0045927 104 0.038
negative regulation of phosphorus metabolic process GO:0010563 184 0.038
regulation of cellular response to stress GO:0080135 159 0.038
negative regulation of molecular function GO:0044092 258 0.038
adiponectin activated signaling pathway GO:0033211 4 0.038
cerebellum development GO:0021549 77 0.036
response to nutrient levels GO:0031667 109 0.036
developmental maturation GO:0021700 193 0.036
Zebrafish
regulation of system process GO:0044057 200 0.034
cellular response to oxidative stress GO:0034599 76 0.033
anion transport GO:0006820 177 0.033
negative regulation of heart rate GO:0010459 4 0.033
apoptotic signaling pathway GO:0097190 306 0.032
sensory perception GO:0007600 245 0.032
organic anion transport GO:0015711 137 0.032
regulation of kinase activity GO:0043549 249 0.032
mitotic cell cycle process GO:1903047 159 0.032
cellular amine metabolic process GO:0044106 44 0.030
intrinsic apoptotic signaling pathway GO:0097193 132 0.030
amine metabolic process GO:0009308 45 0.030
transmission of nerve impulse GO:0019226 76 0.030
positive regulation of potassium ion transmembrane transporter activity GO:1901018 1 0.030
sulfur compound metabolic process GO:0006790 100 0.030
heme biosynthetic process GO:0006783 12 0.029
nuclear transport GO:0051169 139 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
regulation of cellular amine metabolic process GO:0033238 20 0.028
response to iron ion GO:0010039 4 0.028
sequestering of metal ion GO:0051238 19 0.028
regulation of intracellular transport GO:0032386 159 0.028
mitochondrion transport along microtubule GO:0047497 3 0.028
oxidation reduction process GO:0055114 342 0.027
protein import into nucleus GO:0006606 95 0.026
negative regulation of phosphorylation GO:0042326 166 0.026
peptidyl amino acid modification GO:0018193 336 0.026
regulation of cytolysis GO:0042268 1 0.025
response to light stimulus GO:0009416 135 0.025
regulation of ion transport GO:0043269 215 0.025
modification dependent macromolecule catabolic process GO:0043632 133 0.025
response to inorganic substance GO:0010035 96 0.025
hydrogen peroxide catabolic process GO:0042744 5 0.024
positive regulation of leukocyte proliferation GO:0070665 73 0.024
carboxylic acid biosynthetic process GO:0046394 86 0.024
protein processing GO:0016485 163 0.024
ribose phosphate metabolic process GO:0019693 291 0.024
cellular metal ion homeostasis GO:0006875 151 0.024
fertilization GO:0009566 127 0.023
ubiquitin dependent protein catabolic process GO:0006511 129 0.023
cellular response to hormone stimulus GO:0032870 150 0.023
negative regulation of protein modification process GO:0031400 163 0.023
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.023
positive regulation of cellular amine metabolic process GO:0033240 5 0.023
response to growth factor GO:0070848 198 0.023
blood circulation GO:0008015 195 0.023
small molecule biosynthetic process GO:0044283 132 0.023
modification dependent protein catabolic process GO:0019941 133 0.023
purine nucleotide metabolic process GO:0006163 302 0.023
ribonucleotide metabolic process GO:0009259 291 0.022
cation transmembrane transport GO:0098655 266 0.022
metal ion homeostasis GO:0055065 189 0.022
nuclear import GO:0051170 95 0.022
acylglycerol metabolic process GO:0006639 55 0.022
nucleobase containing small molecule metabolic process GO:0055086 352 0.022
protein modification by small protein conjugation GO:0032446 187 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.022
inorganic ion transmembrane transport GO:0098660 234 0.022
sa node cell to atrial cardiac muscle cell signalling GO:0086018 4 0.021
protein oligomerization GO:0051259 67 0.021
generation of precursor metabolites and energy GO:0006091 103 0.021
carbohydrate derivative biosynthetic process GO:1901137 183 0.021
response to extracellular stimulus GO:0009991 127 0.021
phospholipid metabolic process GO:0006644 87 0.021
cell maturation GO:0048469 127 0.021
Zebrafish
regulation of cell activation GO:0050865 289 0.021
regulation of cellular catabolic process GO:0031329 242 0.020
cellular response to growth factor stimulus GO:0071363 197 0.020
macromolecule catabolic process GO:0009057 281 0.020
organelle assembly GO:0070925 177 0.020
response to starvation GO:0042594 65 0.020
purine ribonucleotide metabolic process GO:0009150 290 0.020
atp metabolic process GO:0046034 75 0.020
cellular protein catabolic process GO:0044257 155 0.020
divalent inorganic cation homeostasis GO:0072507 138 0.020
negative regulation of intracellular signal transduction GO:1902532 167 0.020
nucleoside metabolic process GO:0009116 246 0.020
locomotory behavior GO:0007626 195 0.019
nucleocytoplasmic transport GO:0006913 139 0.019
negative regulation of phosphate metabolic process GO:0045936 184 0.019
cerebellar cortex morphogenesis GO:0021696 32 0.019
cerebellum morphogenesis GO:0021587 42 0.019
neutral lipid metabolic process GO:0006638 57 0.019
triglyceride metabolic process GO:0006641 51 0.019
carbohydrate metabolic process GO:0005975 230 0.019
regulation of protein processing GO:0070613 96 0.019
reactive oxygen species metabolic process GO:0072593 84 0.019
organelle fission GO:0048285 170 0.019
regulation of heart contraction GO:0008016 77 0.019
central nervous system neuron differentiation GO:0021953 162 0.018
hormone mediated signaling pathway GO:0009755 23 0.018
cellular chemical homeostasis GO:0055082 215 0.018
negative regulation of transferase activity GO:0051348 85 0.018
spermatogenesis GO:0007283 284 0.018
purine containing compound metabolic process GO:0072521 311 0.018
cytoplasmic transport GO:0016482 234 0.018
action potential GO:0001508 78 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.018
glycerophospholipid metabolic process GO:0006650 71 0.018
t cell proliferation GO:0042098 120 0.018
microtubule based process GO:0007017 236 0.017
mitotic cell cycle GO:0000278 195 0.017
monocarboxylic acid transport GO:0015718 44 0.017
cell type specific apoptotic process GO:0097285 268 0.017
ribonucleoside triphosphate metabolic process GO:0009199 220 0.017
regulation of leukocyte proliferation GO:0070663 121 0.017
regulation of cytokine production GO:0001817 266 0.017
negative regulation of homeostatic process GO:0032845 71 0.017
adult behavior GO:0030534 135 0.017
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 10 0.017
neuronal action potential GO:0019228 54 0.017
multicellular organismal homeostasis GO:0048871 164 0.017
cerebellar purkinje cell layer development GO:0021680 26 0.017
protein targeting GO:0006605 143 0.017
cation homeostasis GO:0055080 212 0.016
purine nucleoside triphosphate metabolic process GO:0009144 226 0.016
regulation of cellular response to growth factor stimulus GO:0090287 82 0.016
regulation of nucleotide catabolic process GO:0030811 122 0.016
regulation of lymphocyte proliferation GO:0050670 117 0.016
establishment of protein localization to membrane GO:0090150 54 0.016
protein homooligomerization GO:0051260 43 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
negative regulation of protein activation cascade GO:2000258 3 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.016
negative regulation of complement activation GO:0045916 3 0.016
lipid biosynthetic process GO:0008610 179 0.016
sensory perception of mechanical stimulus GO:0050954 107 0.016
response to reactive oxygen species GO:0000302 56 0.016
pyruvate transport GO:0006848 2 0.016
organic hydroxy compound metabolic process GO:1901615 203 0.015
regulation of reactive oxygen species metabolic process GO:2000377 40 0.015
establishment of protein localization to organelle GO:0072594 118 0.015
nucleoside phosphate metabolic process GO:0006753 338 0.015
signal transduction in absence of ligand GO:0038034 55 0.015
regulation of organelle organization GO:0033043 289 0.015
cerebellar cortex development GO:0021695 48 0.015
purine nucleoside metabolic process GO:0042278 241 0.015
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.015
carboxylic acid transport GO:0046942 100 0.015
response to metal ion GO:0010038 47 0.015
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.015
nucleoside monophosphate metabolic process GO:0009123 85 0.015
cellular amino acid biosynthetic process GO:0008652 22 0.015
regulation of binding GO:0051098 111 0.015
forebrain development GO:0030900 302 0.015
multicellular organismal signaling GO:0035637 91 0.015
myeloid leukocyte differentiation GO:0002573 119 0.015
ribonucleoside metabolic process GO:0009119 245 0.015
heart contraction GO:0060047 93 0.014
regulation of transmembrane transport GO:0034762 128 0.014
purine ribonucleoside metabolic process GO:0046128 241 0.014
activation of membrane attack complex GO:0001905 4 0.014
divalent inorganic cation transport GO:0072511 178 0.014
muscle cell differentiation GO:0042692 261 0.014
adult locomotory behavior GO:0008344 91 0.014
positive regulation of programmed cell death GO:0043068 218 0.014
regulation of protein binding GO:0043393 60 0.014
fatty acid metabolic process GO:0006631 121 0.014
hindbrain morphogenesis GO:0021575 46 0.014
multi organism behavior GO:0051705 62 0.014
regulation of t cell activation GO:0050863 170 0.014
nonribosomal peptide biosynthetic process GO:0019184 5 0.014
dna endoreduplication GO:0042023 4 0.014
regulation of protein localization GO:0032880 231 0.014
striated muscle tissue development GO:0014706 293 0.013
regulation of protein kinase activity GO:0045859 232 0.013
regulation of protein maturation GO:1903317 96 0.013
regulation of mapk cascade GO:0043408 248 0.013
protein import GO:0017038 101 0.013
muscle tissue development GO:0060537 308 0.013
regulation of leukocyte differentiation GO:1902105 159 0.013
negative regulation of cellular amine metabolic process GO:0033239 1 0.013
response to organonitrogen compound GO:0010243 246 0.013
divalent metal ion transport GO:0070838 172 0.013
digestive tract development GO:0048565 190 0.013
multicellular organismal aging GO:0010259 24 0.013
calcium ion homeostasis GO:0055074 127 0.013
cellular modified amino acid metabolic process GO:0006575 63 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
organophosphate biosynthetic process GO:0090407 122 0.012
cell cycle g1 s phase transition GO:0044843 57 0.012
negative regulation of organelle organization GO:0010639 90 0.012
organic cyclic compound catabolic process GO:1901361 295 0.012
calcium ion transport GO:0006816 159 0.012
sequestering of calcium ion GO:0051208 18 0.012
guanosine containing compound metabolic process GO:1901068 144 0.012
endocytic recycling GO:0032456 7 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
negative regulation of cell cycle GO:0045786 123 0.012
ossification GO:0001503 216 0.012
mapk cascade GO:0000165 281 0.012
response to molecule of bacterial origin GO:0002237 143 0.012
nucleotide biosynthetic process GO:0009165 78 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.012
negative regulation of protein processing GO:0010955 79 0.012
negative regulation of apoptotic signaling pathway GO:2001234 104 0.012
neuron death GO:0070997 154 0.012
organic acid transport GO:0015849 101 0.012
immune effector process GO:0002252 321 0.012
thioester biosynthetic process GO:0035384 7 0.012
lymphocyte proliferation GO:0046651 164 0.012
extrinsic apoptotic signaling pathway GO:0097191 126 0.012
synapse organization GO:0050808 125 0.012
purine nucleotide biosynthetic process GO:0006164 65 0.012
regulation of cell cycle GO:0051726 281 0.012
paracrine signaling GO:0038001 1 0.012
liver development GO:0001889 66 0.011
protein acylation GO:0043543 64 0.011
small gtpase mediated signal transduction GO:0007264 97 0.011
multi multicellular organism process GO:0044706 109 0.011
heart morphogenesis GO:0003007 178 0.011
negative regulation of kinase activity GO:0033673 81 0.011
negative regulation of protein phosphorylation GO:0001933 126 0.011
cation transport GO:0006812 399 0.011
protein localization to nucleus GO:0034504 121 0.011
regulation of t cell proliferation GO:0042129 92 0.011
glycosyl compound metabolic process GO:1901657 246 0.011
xenobiotic catabolic process GO:0042178 1 0.011
positive regulation of lymphocyte proliferation GO:0050671 70 0.011
positive regulation of gtpase activity GO:0043547 85 0.011
anatomical structure homeostasis GO:0060249 145 0.011
protein targeting to membrane GO:0006612 20 0.011
lipoprotein metabolic process GO:0042157 43 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
meiotic cell cycle GO:0051321 122 0.011
neural tube closure GO:0001843 90 0.011
water soluble vitamin metabolic process GO:0006767 10 0.011
positive regulation of protein modification process GO:0031401 299 0.011
cellular response to arsenic containing substance GO:0071243 4 0.011
regulation of cardiac muscle cell membrane potential GO:0086036 3 0.011
wnt signaling pathway GO:0016055 188 0.011
negative regulation of dna replication GO:0008156 4 0.011
stem cell maintenance GO:0019827 130 0.011
fibroblast growth factor production GO:0090269 4 0.011
male gamete generation GO:0048232 285 0.011
long chain fatty acid import GO:0044539 2 0.011
myelination GO:0042552 74 0.011
negative regulation of immune system process GO:0002683 209 0.011
heart process GO:0003015 94 0.011
ion transmembrane transport GO:0034220 361 0.011
reactive nitrogen species metabolic process GO:2001057 0 0.011
nucleoside phosphate catabolic process GO:1901292 222 0.011
nitrogen compound transport GO:0071705 271 0.010
response to organic cyclic compound GO:0014070 198 0.010
ribonucleotide biosynthetic process GO:0009260 59 0.010
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.010
regulation of defense response GO:0031347 233 0.010
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.010
purine nucleoside monophosphate metabolic process GO:0009126 81 0.010
activation of immune response GO:0002253 138 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
circulatory system process GO:0003013 197 0.010
glycoprotein biosynthetic process GO:0009101 89 0.010
striated muscle cell development GO:0055002 125 0.010
retrograde vesicle mediated transport golgi to er GO:0006890 1 0.010
actin mediated cell contraction GO:0070252 15 0.010
heterocycle catabolic process GO:0046700 280 0.010
organophosphate catabolic process GO:0046434 232 0.010
purine ribonucleoside catabolic process GO:0046130 205 0.010
purine containing compound biosynthetic process GO:0072522 70 0.010
rho protein signal transduction GO:0007266 32 0.010
organic hydroxy compound catabolic process GO:1901616 25 0.010

Fech disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
anemia DOID:2355 0 0.513
immune system disease DOID:2914 0 0.513
hematopoietic system disease DOID:74 0 0.513
disease of anatomical entity DOID:7 0 0.513
disease of metabolism DOID:0014667 0 0.169
inherited metabolic disorder DOID:655 0 0.080
nervous system disease DOID:863 0 0.048
central nervous system disease DOID:331 0 0.041
normocytic anemia DOID:720 0 0.025
hemolytic anemia DOID:583 0 0.025
neurodegenerative disease DOID:1289 0 0.023
sensory system disease DOID:0050155 0 0.014
eye and adnexa disease DOID:1492 0 0.014
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
eye disease DOID:5614 0 0.010