Mus musculus

12 known processes

Fh1

fumarate hydratase 1

(Aliases: Fh,Fh-1)

Fh1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular respiration GO:0045333 38 0.917
Yeast
oxidation reduction process GO:0055114 342 0.900
Yeast
generation of precursor metabolites and energy GO:0006091 103 0.886
Yeast
citrate metabolic process GO:0006101 3 0.797
energy derivation by oxidation of organic compounds GO:0015980 77 0.769
Yeast
nucleoside phosphate metabolic process GO:0006753 338 0.636
nucleoside triphosphate metabolic process GO:0009141 230 0.607
coenzyme metabolic process GO:0006732 52 0.589
purine ribonucleotide metabolic process GO:0009150 290 0.454
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.428
nucleobase containing small molecule metabolic process GO:0055086 352 0.427
purine nucleoside metabolic process GO:0042278 241 0.401
ribose phosphate metabolic process GO:0019693 291 0.386
nucleoside monophosphate metabolic process GO:0009123 85 0.368
atp metabolic process GO:0046034 75 0.360
coenzyme biosynthetic process GO:0009108 23 0.352
nadh metabolic process GO:0006734 1 0.346
ribonucleoside metabolic process GO:0009119 245 0.284
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.273
ribonucleotide metabolic process GO:0009259 291 0.271
cofactor transport GO:0051181 4 0.269
nucleoside metabolic process GO:0009116 246 0.264
purine nucleotide metabolic process GO:0006163 302 0.263
acyl coa metabolic process GO:0006637 19 0.259
ribonucleoside monophosphate metabolic process GO:0009161 80 0.257
purine ribonucleoside metabolic process GO:0046128 241 0.254
glycosyl compound metabolic process GO:1901657 246 0.243
purine nucleoside monophosphate metabolic process GO:0009126 81 0.227
thioester metabolic process GO:0035383 19 0.220
purine nucleoside triphosphate metabolic process GO:0009144 226 0.215
nucleotide metabolic process GO:0009117 332 0.213
succinyl coa metabolic process GO:0006104 1 0.204
oxidative phosphorylation GO:0006119 14 0.184
cellular ketone metabolic process GO:0042180 84 0.181
ribonucleoside triphosphate metabolic process GO:0009199 220 0.160
purine containing compound metabolic process GO:0072521 311 0.137
organonitrogen compound catabolic process GO:1901565 264 0.125
ribonucleotide catabolic process GO:0009261 208 0.115
transmembrane transport GO:0055085 412 0.111
intrinsic apoptotic signaling pathway GO:0097193 132 0.101
mitochondrial atp synthesis coupled electron transport GO:0042775 8 0.093
cell type specific apoptotic process GO:0097285 268 0.086
purine nucleotide catabolic process GO:0006195 211 0.085
regulation of membrane potential GO:0042391 192 0.082
acetyl coa biosynthetic process from pyruvate GO:0006086 3 0.081
positive regulation of apoptotic process GO:0043065 217 0.080
mitochondrial electron transport nadh to ubiquinone GO:0006120 4 0.075
mitochondrion organization GO:0007005 134 0.075
4 hydroxyproline metabolic process GO:0019471 5 0.074
neuron apoptotic process GO:0051402 142 0.073
positive regulation of cell death GO:0010942 224 0.073
aromatic compound catabolic process GO:0019439 286 0.072
cellular amino acid metabolic process GO:0006520 103 0.070
amine metabolic process GO:0009308 45 0.070
regulation of cellular catabolic process GO:0031329 242 0.066
cofactor metabolic process GO:0051186 80 0.064
protein maturation GO:0051604 176 0.063
cellular nitrogen compound catabolic process GO:0044270 280 0.061
protein oxidation GO:0018158 2 0.061
mitochondrial transport GO:0006839 36 0.059
tricarboxylic acid metabolic process GO:0072350 5 0.053
cofactor biosynthetic process GO:0051188 41 0.053
regulation of cellular amino acid metabolic process GO:0006521 5 0.052
regulation of nucleotide metabolic process GO:0006140 169 0.051
nitrogen compound transport GO:0071705 271 0.050
acetyl coa biosynthetic process GO:0006085 5 0.049
regulation of cellular ketone metabolic process GO:0010565 66 0.048
small molecule catabolic process GO:0044282 71 0.048
mitochondrial calcium ion homeostasis GO:0051560 7 0.047
organic cyclic compound catabolic process GO:1901361 295 0.047
peptidyl amino acid modification GO:0018193 336 0.047
synaptic transmission GO:0007268 329 0.046
cellular amine metabolic process GO:0044106 44 0.045
gonad development GO:0008406 141 0.045
alcohol metabolic process GO:0006066 116 0.043
heterocycle catabolic process GO:0046700 280 0.043
action potential GO:0001508 78 0.042
regulation of purine nucleotide metabolic process GO:1900542 169 0.042
anion transport GO:0006820 177 0.042
sulfur compound metabolic process GO:0006790 100 0.042
cation transport GO:0006812 399 0.041
monocarboxylic acid metabolic process GO:0032787 191 0.039
purine containing compound catabolic process GO:0072523 213 0.039
cellular divalent inorganic cation homeostasis GO:0072503 127 0.039
atp synthesis coupled electron transport GO:0042773 8 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.037
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.037
negative regulation of phosphorylation GO:0042326 166 0.036
acyl coa biosynthetic process GO:0071616 7 0.036
organic hydroxy compound metabolic process GO:1901615 203 0.035
locomotory behavior GO:0007626 195 0.035
regulation of atp metabolic process GO:1903578 17 0.034
proton transport GO:0015992 35 0.033
adult behavior GO:0030534 135 0.032
response to molecule of bacterial origin GO:0002237 143 0.032
neural tube formation GO:0001841 108 0.032
apoptotic signaling pathway GO:0097190 306 0.032
small molecule biosynthetic process GO:0044283 132 0.032
regulation of nucleoside metabolic process GO:0009118 130 0.031
cellular ion homeostasis GO:0006873 165 0.031
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.030
dicarboxylic acid metabolic process GO:0043648 18 0.030
Yeast
regulation of reactive oxygen species metabolic process GO:2000377 40 0.030
positive regulation of programmed cell death GO:0043068 218 0.029
purine ribonucleotide catabolic process GO:0009154 208 0.029
purine nucleoside triphosphate catabolic process GO:0009146 203 0.029
purine nucleoside catabolic process GO:0006152 205 0.029
positive regulation of protein modification process GO:0031401 299 0.028
carbohydrate derivative catabolic process GO:1901136 231 0.028
nicotinamide nucleotide metabolic process GO:0046496 12 0.028
substantia nigra development GO:0021762 2 0.028
negative regulation of cell proliferation GO:0008285 296 0.028
lipid localization GO:0010876 126 0.027
organic anion transport GO:0015711 137 0.027
gland development GO:0048732 330 0.027
development of primary sexual characteristics GO:0045137 143 0.027
organophosphate catabolic process GO:0046434 232 0.027
myeloid cell differentiation GO:0030099 233 0.026
regulation of organelle organization GO:0033043 289 0.026
metal ion homeostasis GO:0055065 189 0.026
lipid oxidation GO:0034440 29 0.026
positive regulation of interleukin 8 production GO:0032757 2 0.026
positive regulation of cellular amine metabolic process GO:0033240 5 0.026
cytoplasmic transport GO:0016482 234 0.026
negative regulation of phosphate metabolic process GO:0045936 184 0.026
regulation of cellular amine metabolic process GO:0033238 20 0.026
neuron death GO:0070997 154 0.025
carbohydrate derivative biosynthetic process GO:1901137 183 0.025
nucleoside triphosphate catabolic process GO:0009143 205 0.025
inorganic cation transmembrane transport GO:0098662 207 0.025
alpha amino acid metabolic process GO:1901605 59 0.025
response to oxygen levels GO:0070482 62 0.025
divalent inorganic cation homeostasis GO:0072507 138 0.025
cation homeostasis GO:0055080 212 0.024
quinone metabolic process GO:1901661 7 0.024
nucleoside phosphate catabolic process GO:1901292 222 0.024
cellular lipid metabolic process GO:0044255 323 0.024
succinate metabolic process GO:0006105 4 0.024
aldehyde catabolic process GO:0046185 4 0.023
dna metabolic process GO:0006259 303 0.023
response to lipopolysaccharide GO:0032496 128 0.023
heme transport GO:0015886 2 0.023
ribonucleotide biosynthetic process GO:0009260 59 0.023
homeostasis of number of cells GO:0048872 210 0.023
cellular metal ion homeostasis GO:0006875 151 0.023
striated muscle tissue development GO:0014706 293 0.023
extrinsic apoptotic signaling pathway GO:0097191 126 0.023
ion transmembrane transport GO:0034220 361 0.023
age dependent response to oxidative stress GO:0001306 3 0.022
regulation of endopeptidase activity GO:0052548 89 0.022
regulation of ion transport GO:0043269 215 0.022
lymphocyte mediated immunity GO:0002449 139 0.022
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.022
ribonucleoside catabolic process GO:0042454 206 0.022
regulation of defense response GO:0031347 233 0.022
regulation of neuron apoptotic process GO:0043523 122 0.021
regulation of secretion GO:0051046 274 0.021
ribose phosphate biosynthetic process GO:0046390 59 0.021
quinone biosynthetic process GO:1901663 4 0.021
cellular modified amino acid metabolic process GO:0006575 63 0.021
regulation of transmembrane transport GO:0034762 128 0.021
regulation of hormone levels GO:0010817 211 0.021
organonitrogen compound biosynthetic process GO:1901566 192 0.021
regulation of hydrolase activity GO:0051336 246 0.021
protein oligomerization GO:0051259 67 0.021
natural killer cell mediated cytotoxicity GO:0042267 29 0.021
calcium ion homeostasis GO:0055074 127 0.021
nucleoside catabolic process GO:0009164 206 0.020
regulation of cysteine type endopeptidase activity GO:2000116 65 0.020
negative regulation of transferase activity GO:0051348 85 0.020
microtubule cytoskeleton organization GO:0000226 157 0.020
spermatogenesis GO:0007283 284 0.020
inflammatory response GO:0006954 244 0.020
peptidyl cysteine modification GO:0018198 8 0.019
age dependent general metabolic decline GO:0007571 3 0.019
steroid metabolic process GO:0008202 119 0.019
mitochondrial protein processing GO:0034982 5 0.019
reactive oxygen species biosynthetic process GO:1903409 8 0.019
male gamete generation GO:0048232 285 0.019
determination of adult lifespan GO:0008340 11 0.019
cellular response to oxidative stress GO:0034599 76 0.019
cellular homeostasis GO:0019725 240 0.019
negative regulation of cellular amine metabolic process GO:0033239 1 0.019
hydrogen ion transmembrane transport GO:1902600 25 0.019
porphyrin containing compound metabolic process GO:0006778 22 0.019
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.019
protein processing GO:0016485 163 0.019
negative regulation of neuron apoptotic process GO:0043524 92 0.018
oxidoreduction coenzyme metabolic process GO:0006733 16 0.018
neural precursor cell proliferation GO:0061351 121 0.018
membrane organization GO:0061024 245 0.018
multicellular organism growth GO:0035264 161 0.018
negative regulation of intracellular signal transduction GO:1902532 167 0.018
cytokine production GO:0001816 319 0.018
aerobic respiration GO:0009060 7 0.018
Yeast
reactive oxygen species metabolic process GO:0072593 84 0.018
regulation of cell activation GO:0050865 289 0.018
hormone metabolic process GO:0042445 86 0.018
cardiac muscle tissue development GO:0048738 130 0.018
cation transmembrane transport GO:0098655 266 0.018
response to organonitrogen compound GO:0010243 246 0.018
positive regulation of proteolysis GO:0045862 85 0.018
removal of superoxide radicals GO:0019430 12 0.017
blood circulation GO:0008015 195 0.017
positive regulation of protein kinase activity GO:0045860 144 0.017
cellular macromolecule catabolic process GO:0044265 206 0.017
response to oxidative stress GO:0006979 123 0.017
regulation of neurotransmitter levels GO:0001505 87 0.017
dna catabolic process endonucleolytic GO:0000737 15 0.017
muscle tissue development GO:0060537 308 0.017
regulation of apoptotic signaling pathway GO:2001233 197 0.016
maintenance of location GO:0051235 89 0.016
regulation of lymphocyte activation GO:0051249 240 0.016
epithelial tube morphogenesis GO:0060562 303 0.016
positive regulation of hydrolase activity GO:0051345 148 0.016
leukocyte differentiation GO:0002521 342 0.016
purine nucleotide biosynthetic process GO:0006164 65 0.016
regulation of neuron death GO:1901214 134 0.016
monoamine transport GO:0015844 33 0.016
cellular response to biotic stimulus GO:0071216 92 0.016
development of primary male sexual characteristics GO:0046546 88 0.016
regulation of transferase activity GO:0051338 263 0.016
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.016
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.015
positive regulation of growth GO:0045927 104 0.015
protein localization to organelle GO:0033365 185 0.015
positive regulation of endopeptidase activity GO:0010950 43 0.015
epithelial cell proliferation GO:0050673 174 0.015
embryonic epithelial tube formation GO:0001838 130 0.015
cellular chemical homeostasis GO:0055082 215 0.015
heart morphogenesis GO:0003007 178 0.015
connective tissue development GO:0061448 179 0.015
cellular response to lipopolysaccharide GO:0071222 77 0.015
adult locomotory behavior GO:0008344 91 0.015
male sex differentiation GO:0046661 109 0.015
regulation of atp biosynthetic process GO:2001169 3 0.015
acetyl coa metabolic process GO:0006084 8 0.015
pyridine nucleotide metabolic process GO:0019362 12 0.015
regulation of kinase activity GO:0043549 249 0.015
t cell activation GO:0042110 289 0.015
cellular amino acid catabolic process GO:0009063 25 0.014
negative regulation of neuron death GO:1901215 98 0.014
negative regulation of phosphorus metabolic process GO:0010563 184 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
macromolecule catabolic process GO:0009057 281 0.014
mitochondrial electron transport ubiquinol to cytochrome c GO:0006122 2 0.014
lipid catabolic process GO:0016042 69 0.014
immune effector process GO:0002252 321 0.014
organophosphate biosynthetic process GO:0090407 122 0.014
regulation of peptidase activity GO:0052547 96 0.014
regulation of blood pressure GO:0008217 93 0.014
positive regulation of atp biosynthetic process GO:2001171 2 0.013
divalent metal ion transport GO:0070838 172 0.013
multicellular organismal aging GO:0010259 24 0.013
response to oxygen radical GO:0000305 16 0.013
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.013
morphogenesis of embryonic epithelium GO:0016331 159 0.013
lateral inhibition GO:0046331 1 0.013
cellular response to superoxide GO:0071451 14 0.013
regulation of mitochondrial membrane potential GO:0051881 17 0.013
regulation of response to wounding GO:1903034 189 0.013
response to superoxide GO:0000303 16 0.013
negative regulation of molecular function GO:0044092 258 0.013
regulation of secretion by cell GO:1903530 249 0.012
protein acylation GO:0043543 64 0.012
regulation of wound healing GO:0061041 40 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.012
regulation of cytokine production GO:0001817 266 0.012
hepaticobiliary system development GO:0061008 67 0.012
interleukin 8 production GO:0032637 4 0.012
inorganic ion transmembrane transport GO:0098660 234 0.012
negative regulation of protein metabolic process GO:0051248 282 0.012
synaptic vesicle transport GO:0048489 57 0.012
atp catabolic process GO:0006200 55 0.012
negative regulation of eosinophil degranulation GO:0043310 1 0.012
regulation of transporter activity GO:0032409 57 0.012
cellular response to oxygen radical GO:0071450 14 0.012
organic hydroxy compound transport GO:0015850 93 0.012
anatomical structure homeostasis GO:0060249 145 0.012
covalent chromatin modification GO:0016569 163 0.012
vesicle localization GO:0051648 86 0.012
cellular response to lipid GO:0071396 145 0.012
microtubule based process GO:0007017 236 0.011
organic hydroxy compound biosynthetic process GO:1901617 77 0.011
regulation of cellular response to stress GO:0080135 159 0.011
nucleotide biosynthetic process GO:0009165 78 0.011
neural tube development GO:0021915 160 0.011
innate immune response GO:0045087 157 0.011
positive regulation of nervous system development GO:0051962 221 0.011
pigment biosynthetic process GO:0046148 26 0.011
regulation of oxidative phosphorylation uncoupler activity GO:2000275 3 0.011
regulation of proteolysis GO:0030162 164 0.011
apoptotic nuclear changes GO:0030262 9 0.011
divalent inorganic cation transport GO:0072511 178 0.011
regulation of removal of superoxide radicals GO:2000121 4 0.011
purine ribonucleoside biosynthetic process GO:0046129 19 0.011
sulfur compound biosynthetic process GO:0044272 37 0.011
diterpenoid metabolic process GO:0016101 24 0.011
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.011
establishment of vesicle localization GO:0051650 81 0.011
myeloid cell homeostasis GO:0002262 114 0.011
regulation of interleukin 8 production GO:0032677 3 0.011
response to organic cyclic compound GO:0014070 198 0.011
endocytosis GO:0006897 168 0.011
purine containing compound biosynthetic process GO:0072522 70 0.011
fatty acid metabolic process GO:0006631 121 0.011
ketone catabolic process GO:0042182 3 0.011
male gonad development GO:0008584 88 0.011
pyridine containing compound metabolic process GO:0072524 14 0.010
nucleoside phosphate biosynthetic process GO:1901293 79 0.010
negative regulation of cellular protein metabolic process GO:0032269 247 0.010
glycosyl compound catabolic process GO:1901658 206 0.010
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.010
regulation of establishment of protein localization GO:0070201 181 0.010
nucleotide catabolic process GO:0009166 217 0.010
positive regulation of organelle organization GO:0010638 128 0.010
positive regulation of nucleotide metabolic process GO:0045981 114 0.010

Fh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.131
inherited metabolic disorder DOID:655 0 0.131
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.036
disease of cellular proliferation DOID:14566 0 0.034
cancer DOID:162 0 0.021
central nervous system disease DOID:331 0 0.021
organ system cancer DOID:0050686 0 0.015
neurodegenerative disease DOID:1289 0 0.013
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
eye disease DOID:5614 0 0.013