Mus musculus

42 known processes

Gdf15

growth differentiation factor 15

(Aliases: NAG-1,SBF,MIC-1)

Gdf15 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cytokine production GO:0001816 319 0.425
leukocyte differentiation GO:0002521 342 0.407
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.399
negative regulation of response to wounding GO:1903035 77 0.397
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.386
regulation of defense response GO:0031347 233 0.380
cellular ketone metabolic process GO:0042180 84 0.369
cellular amino acid metabolic process GO:0006520 103 0.339
regulation of transferase activity GO:0051338 263 0.307
apoptotic signaling pathway GO:0097190 306 0.291
amine metabolic process GO:0009308 45 0.269
regulation of cellular amino acid metabolic process GO:0006521 5 0.266
regulation of kinase activity GO:0043549 249 0.260
regulation of cellular ketone metabolic process GO:0010565 66 0.260
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.255
homeostasis of number of cells GO:0048872 210 0.255
regulation of t helper 1 cell cytokine production GO:2000554 1 0.240
regulation of cytokine production GO:0001817 266 0.234
organic acid transport GO:0015849 101 0.233
regulation of response to wounding GO:1903034 189 0.233
inflammatory response GO:0006954 244 0.223
gland development GO:0048732 330 0.212
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.211
t helper 2 cell cytokine production GO:0035745 4 0.203
response to molecule of bacterial origin GO:0002237 143 0.201
positive regulation of leukocyte mediated immunity GO:0002705 70 0.189
organic acid biosynthetic process GO:0016053 86 0.188
production of molecular mediator of immune response GO:0002440 103 0.188
positive regulation of protein kinase activity GO:0045860 144 0.186
positive regulation of mapk cascade GO:0043410 170 0.185
immune effector process GO:0002252 321 0.181
striated muscle tissue development GO:0014706 293 0.178
leukocyte mediated immunity GO:0002443 174 0.178
natural killer cell chemotaxis GO:0035747 1 0.174
negative regulation of transferase activity GO:0051348 85 0.164
carboxylic acid biosynthetic process GO:0046394 86 0.163
epithelial tube morphogenesis GO:0060562 303 0.161
positive regulation of cell death GO:0010942 224 0.161
defense response to other organism GO:0098542 197 0.160
embryonic placenta development GO:0001892 98 0.159
acid secretion GO:0046717 33 0.157
regionalization GO:0003002 337 0.156
spermatogenesis GO:0007283 284 0.154
cellular response to dna damage stimulus GO:0006974 207 0.152
skeletal system development GO:0001501 356 0.151
positive regulation of immune effector process GO:0002699 107 0.149
regulation of protein serine threonine kinase activity GO:0071900 157 0.144
regulation of leukocyte mediated immunity GO:0002703 104 0.143
negative regulation of inflammatory response GO:0050728 61 0.141
regulation of secretion GO:0051046 274 0.136
regulation of multi organism process GO:0043900 111 0.135
regulation of inflammatory response GO:0050727 147 0.135
fatty acid metabolic process GO:0006631 121 0.133
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.132
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.128
positive regulation of cellular amine metabolic process GO:0033240 5 0.124
extracellular matrix organization GO:0030198 147 0.122
cellular response to biotic stimulus GO:0071216 92 0.121
cell killing GO:0001906 67 0.120
cellular amine metabolic process GO:0044106 44 0.120
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.119
positive regulation of protein modification process GO:0031401 299 0.118
modification by host of symbiont morphology or physiology GO:0051851 12 0.116
positive regulation of programmed cell death GO:0043068 218 0.115
fibrinolysis GO:0042730 3 0.113
regulation of striated muscle cell differentiation GO:0051153 81 0.112
negative regulation of kinase activity GO:0033673 81 0.111
positive regulation of transferase activity GO:0051347 167 0.110
regulation of muscle tissue development GO:1901861 97 0.109
positive regulation of cytokine production GO:0001819 174 0.107
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.107
placenta development GO:0001890 140 0.106
posttranscriptional regulation of gene expression GO:0010608 155 0.103
morphogenesis of a branching structure GO:0001763 203 0.103
organonitrogen compound biosynthetic process GO:1901566 192 0.102
rhythmic process GO:0048511 174 0.102
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.101
small molecule biosynthetic process GO:0044283 132 0.100
striated muscle cell development GO:0055002 125 0.097
myeloid cell differentiation GO:0030099 233 0.097
regulation of cellular amine metabolic process GO:0033238 20 0.097
dna metabolic process GO:0006259 303 0.096
regulation of natural killer cell chemotaxis GO:2000501 1 0.095
modification dependent macromolecule catabolic process GO:0043632 133 0.093
carbohydrate metabolic process GO:0005975 230 0.092
gastrulation GO:0007369 116 0.091
response to organonitrogen compound GO:0010243 246 0.090
lipid transport GO:0006869 98 0.090
protein modification by small protein conjugation GO:0032446 187 0.090
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.089
leukocyte mediated cytotoxicity GO:0001909 62 0.089
wound healing GO:0042060 157 0.089
lymphocyte mediated immunity GO:0002449 139 0.088
positive regulation of leukocyte differentiation GO:1902107 86 0.088
extracellular structure organization GO:0043062 148 0.086
alpha beta t cell activation GO:0046631 91 0.086
negative regulation of phosphorylation GO:0042326 166 0.085
positive regulation of lymphocyte activation GO:0051251 140 0.085
positive regulation of defense response GO:0031349 124 0.085
negative regulation of intracellular signal transduction GO:1902532 167 0.084
regulation of organ morphogenesis GO:2000027 144 0.084
hematopoietic progenitor cell differentiation GO:0002244 143 0.084
epithelial cell proliferation GO:0050673 174 0.084
cellular response to molecule of bacterial origin GO:0071219 83 0.083
t cell activation GO:0042110 289 0.082
regulation of cell activation GO:0050865 289 0.082
cell type specific apoptotic process GO:0097285 268 0.080
regulation of map kinase activity GO:0043405 120 0.079
positive regulation of protein phosphorylation GO:0001934 242 0.079
cellular response to lipopolysaccharide GO:0071222 77 0.078
regulation of activation of jak2 kinase activity GO:0010534 1 0.077
camera type eye development GO:0043010 266 0.077
positive regulation of myotube differentiation GO:0010831 24 0.076
lymphocyte differentiation GO:0030098 242 0.076
interleukin 12 production GO:0032615 32 0.076
protein ubiquitination GO:0016567 171 0.074
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.074
regulation of protein localization GO:0032880 231 0.073
lipid biosynthetic process GO:0008610 179 0.073
peptidyl amino acid modification GO:0018193 336 0.072
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.071
interspecies interaction between organisms GO:0044419 83 0.071
multicellular organismal homeostasis GO:0048871 164 0.071
regulation of t helper cell differentiation GO:0045622 14 0.071
cellular response to organonitrogen compound GO:0071417 145 0.070
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.070
negative regulation of cell proliferation GO:0008285 296 0.069
regulation of b cell mediated immunity GO:0002712 37 0.069
cell recognition GO:0008037 83 0.068
negative regulation of protein modification process GO:0031400 163 0.068
negative regulation of cellular protein metabolic process GO:0032269 247 0.068
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.068
glomerular mesangial cell development GO:0072144 3 0.067
monocarboxylic acid metabolic process GO:0032787 191 0.067
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.067
cellular lipid metabolic process GO:0044255 323 0.066
regulation of carbohydrate metabolic process GO:0006109 75 0.065
regulation of apoptotic signaling pathway GO:2001233 197 0.065
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.064
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.064
t cell proliferation GO:0042098 120 0.064
wound healing involved in inflammatory response GO:0002246 4 0.064
regulation of interleukin 8 production GO:0032677 3 0.064
cellular response to cytokine stimulus GO:0071345 189 0.064
male gamete generation GO:0048232 285 0.064
b cell activation GO:0042113 161 0.063
negative regulation of molecular function GO:0044092 258 0.063
regulation of t helper 2 cell cytokine production GO:2000551 3 0.063
trophoblast giant cell differentiation GO:0060707 15 0.063
cation transport GO:0006812 399 0.062
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.062
protein modification by small protein conjugation or removal GO:0070647 207 0.061
astrocyte cell migration GO:0043615 3 0.061
regulation of t helper 1 cell differentiation GO:0045625 7 0.061
morphogenesis of a branching epithelium GO:0061138 193 0.061
circulatory system process GO:0003013 197 0.061
regulation of plasminogen activation GO:0010755 4 0.060
adaptive immune response GO:0002250 155 0.060
lipid localization GO:0010876 126 0.060
regulation of b cell chemotaxis GO:2000537 2 0.060
cellular macromolecule catabolic process GO:0044265 206 0.060
response to inorganic substance GO:0010035 96 0.060
positive regulation of kinase activity GO:0033674 155 0.059
cd4 positive alpha beta t cell activation GO:0035710 45 0.059
extrinsic apoptotic signaling pathway GO:0097191 126 0.058
regulation of mapk cascade GO:0043408 248 0.058
nucleobase containing small molecule metabolic process GO:0055086 352 0.058
regulation of membrane potential GO:0042391 192 0.058
anion transport GO:0006820 177 0.057
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.057
muscle tissue development GO:0060537 308 0.056
innate immune response GO:0045087 157 0.056
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.056
cation homeostasis GO:0055080 212 0.056
regulation of t cell mediated immunity GO:0002709 34 0.056
regulation of t cell activation GO:0050863 170 0.055
multicellular organism growth GO:0035264 161 0.055
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.055
carboxylic acid transport GO:0046942 100 0.055
response to lipopolysaccharide GO:0032496 128 0.055
regulation of lymphocyte mediated immunity GO:0002706 84 0.054
positive regulation of leukocyte proliferation GO:0070665 73 0.054
leukocyte proliferation GO:0070661 172 0.054
myotube differentiation GO:0014902 105 0.054
nucleotide metabolic process GO:0009117 332 0.054
defense response to bacterium GO:0042742 119 0.054
skin development GO:0043588 220 0.054
t helper 1 cell cytokine production GO:0035744 1 0.054
regulation of neuron differentiation GO:0045664 281 0.053
negative regulation of myoblast differentiation GO:0045662 18 0.053
digestive system development GO:0055123 200 0.053
nitrogen compound transport GO:0071705 271 0.053
regulation of tumor necrosis factor production GO:0032680 49 0.052
positive regulation of apoptotic process GO:0043065 217 0.052
mesonephric epithelium development GO:0072163 94 0.052
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.052
positive regulation of map kinase activity GO:0043406 84 0.052
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.052
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.052
leukocyte migration GO:0050900 124 0.052
regulation of leukocyte proliferation GO:0070663 121 0.052
regulation of protein kinase activity GO:0045859 232 0.051
positive regulation of cell activation GO:0050867 158 0.051
developmental programmed cell death GO:0010623 41 0.051
regulation of antimicrobial humoral response GO:0002759 3 0.051
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.051
cellular chemical homeostasis GO:0055082 215 0.051
cell fate commitment GO:0045165 210 0.050
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.050
regulation of cellular response to stress GO:0080135 159 0.050
organ or tissue specific immune response GO:0002251 13 0.050
oxidation reduction process GO:0055114 342 0.049
g protein coupled receptor signaling pathway GO:0007186 243 0.049
sensory organ morphogenesis GO:0090596 242 0.049
keratinocyte migration GO:0051546 3 0.049
cellular response to lipid GO:0071396 145 0.049
neuron death GO:0070997 154 0.049
defense response to virus GO:0051607 68 0.049
lymphocyte proliferation GO:0046651 164 0.049
dna endoreduplication GO:0042023 4 0.049
skeletal muscle organ development GO:0060538 163 0.048
positive regulation of production of molecular mediator of immune response GO:0002702 45 0.048
regulation of adaptive immune response GO:0002819 90 0.048
positive regulation of t cell mediated immunity GO:0002711 24 0.048
syncytium formation by plasma membrane fusion GO:0000768 42 0.048
monocarboxylic acid biosynthetic process GO:0072330 61 0.047
negative regulation of defense response GO:0031348 77 0.047
disruption by host of symbiont cells GO:0051852 11 0.047
cellular protein catabolic process GO:0044257 155 0.047
immunoglobulin mediated immune response GO:0016064 69 0.047
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.047
monocarboxylic acid transport GO:0015718 44 0.046
regulation of glucose transport GO:0010827 32 0.046
t cell activation involved in immune response GO:0002286 43 0.046
hindbrain development GO:0030902 128 0.046
tyrosine phosphorylation of stat1 protein GO:0042508 3 0.046
alcohol metabolic process GO:0006066 116 0.046
inflammatory response to wounding GO:0090594 4 0.045
interleukin 13 secretion GO:0072611 2 0.045
defense response to gram positive bacterium GO:0050830 50 0.045
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.045
zymogen activation GO:0031638 41 0.045
interaction with symbiont GO:0051702 14 0.045
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.045
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.045
positive regulation of adaptive immune response GO:0002821 61 0.045
fertilization GO:0009566 127 0.045
blastocyst development GO:0001824 80 0.044
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.044
urogenital system development GO:0001655 261 0.043
response to interleukin 4 GO:0070670 23 0.043
b cell chemotaxis GO:0035754 3 0.043
regulation of neuron death GO:1901214 134 0.043
neutrophil mediated killing of fungus GO:0070947 3 0.042
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.042
molting cycle GO:0042303 90 0.042
mapk cascade GO:0000165 281 0.041
regulation of alpha beta t cell activation GO:0046634 53 0.041
positive regulation of hematopoietic stem cell proliferation GO:1902035 2 0.041
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.041
regulation of lymphocyte proliferation GO:0050670 117 0.041
heart morphogenesis GO:0003007 178 0.040
positive regulation of b cell chemotaxis GO:2000538 2 0.040
regulation of lymphocyte activation GO:0051249 240 0.040
organic hydroxy compound transport GO:0015850 93 0.039
positive regulation of cell killing GO:0031343 33 0.039
reactive oxygen species metabolic process GO:0072593 84 0.039
regulation of establishment of protein localization GO:0070201 181 0.039
placenta blood vessel development GO:0060674 31 0.039
regulation of secretion by cell GO:1903530 249 0.039
positive regulation of secretion GO:0051047 130 0.039
response to decreased oxygen levels GO:0036293 59 0.039
alpha beta t cell differentiation GO:0046632 69 0.038
immunoglobulin production GO:0002377 73 0.038
regulation of alpha beta t cell differentiation GO:0046637 35 0.038
positive regulation of neuron differentiation GO:0045666 141 0.038
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.038
immunoglobulin production in mucosal tissue GO:0002426 3 0.038
positive regulation of interleukin 12 production GO:0032735 21 0.038
negative regulation of cellular amine metabolic process GO:0033239 1 0.037
neutrophil migration GO:1990266 37 0.037
regulation of fatty acid transport GO:2000191 10 0.037
regulation of response to biotic stimulus GO:0002831 38 0.037
organic anion transport GO:0015711 137 0.037
regulation of ion transport GO:0043269 215 0.037
regulation of adiponectin secretion GO:0070163 2 0.037
detection of stimulus GO:0051606 84 0.036
proteasomal protein catabolic process GO:0010498 98 0.036
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.036
regulation of skeletal muscle fiber development GO:0048742 36 0.036
brain segmentation GO:0035284 3 0.036
superoxide anion generation GO:0042554 11 0.036
negative regulation of muscle cell differentiation GO:0051148 33 0.036
translation GO:0006412 93 0.036
antimicrobial peptide production GO:0002775 2 0.036
mature natural killer cell chemotaxis GO:0035782 1 0.036
glycoprotein metabolic process GO:0009100 116 0.036
muscle cell differentiation GO:0042692 261 0.036
signal transduction in absence of ligand GO:0038034 55 0.035
macromolecule catabolic process GO:0009057 281 0.035
cell chemotaxis GO:0060326 81 0.035
glomerular endothelium development GO:0072011 2 0.035
stress activated protein kinase signaling cascade GO:0031098 81 0.035
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.035
hexose metabolic process GO:0019318 98 0.035
regulation of cellular catabolic process GO:0031329 242 0.034
response to organic cyclic compound GO:0014070 198 0.034
regulation of homeostatic process GO:0032844 182 0.034
mature dendritic cell differentiation GO:0097029 3 0.034
epidermis development GO:0008544 187 0.034
regulation of production of molecular mediator of immune response GO:0002700 65 0.034
intrinsic apoptotic signaling pathway GO:0097193 132 0.034
transmembrane transport GO:0055085 412 0.034
circadian rhythm GO:0007623 114 0.034
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.034
regulation of glucose metabolic process GO:0010906 60 0.034
regulation of defense response to bacterium GO:1900424 3 0.034
negative regulation of protein metabolic process GO:0051248 282 0.034
regulation of stem cell proliferation GO:0072091 78 0.034
regulation of mitotic cell cycle GO:0007346 126 0.033
retina development in camera type eye GO:0060041 119 0.033
response to insulin GO:0032868 100 0.033
lateral inhibition GO:0046331 1 0.033
positive regulation of cell migration GO:0030335 109 0.033
positive regulation of transcription by glucose GO:0046016 3 0.033
atrial cardiac muscle cell differentiation GO:0055011 2 0.033
negative regulation of cytokine production GO:0001818 84 0.033
tumor necrosis factor production GO:0032640 50 0.033
connective tissue development GO:0061448 179 0.033
cellular amide metabolic process GO:0043603 58 0.033
neuron apoptotic process GO:0051402 142 0.033
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.033
regulation of cell cycle GO:0051726 281 0.033
regulation of cell migration GO:0030334 219 0.032
hormone secretion GO:0046879 128 0.032
hepatocyte growth factor receptor signaling pathway GO:0048012 3 0.032
positive regulation of stress activated mapk cascade GO:0032874 48 0.032
t helper 17 cell lineage commitment GO:0072540 4 0.032
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.032
cerebral cortex radially oriented cell migration GO:0021799 31 0.032
regulation of nucleotide metabolic process GO:0006140 169 0.032
divalent metal ion transport GO:0070838 172 0.032
response to peptide GO:1901652 136 0.031
antimicrobial peptide biosynthetic process GO:0002777 2 0.031
positive regulation of cell development GO:0010720 237 0.031
aromatic compound catabolic process GO:0019439 286 0.031
polysaccharide metabolic process GO:0005976 39 0.031
positive regulation of macrophage chemotaxis GO:0010759 5 0.031
epithelial mesenchymal signaling involved in prostate gland development GO:0060738 2 0.031
neutrophil mediated cytotoxicity GO:0070942 8 0.031
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.030
positive regulation of interleukin 6 production GO:0032755 37 0.030
negative regulation of phosphorus metabolic process GO:0010563 184 0.030
small gtpase mediated signal transduction GO:0007264 97 0.030
muscle cell development GO:0055001 133 0.030
regulation of cell killing GO:0031341 40 0.030
purine nucleotide metabolic process GO:0006163 302 0.030
ossification GO:0001503 216 0.030
response to peptide hormone GO:0043434 127 0.030
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.030
response to extracellular stimulus GO:0009991 127 0.030
neutrophil mediated immunity GO:0002446 19 0.030
jak stat cascade GO:0007259 42 0.030
regulation of myotube differentiation GO:0010830 62 0.030
pancreatic pp cell fate commitment GO:0003329 2 0.030
peptide metabolic process GO:0006518 46 0.030
regulation of tyrosine phosphorylation of stat1 protein GO:0042510 2 0.029
neurotransmitter transport GO:0006836 76 0.029
cholesterol metabolic process GO:0008203 56 0.029
carbohydrate homeostasis GO:0033500 128 0.029
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.029
skeletal system morphogenesis GO:0048705 203 0.029
killing of cells of other organism GO:0031640 13 0.029
regulation of lipid metabolic process GO:0019216 118 0.029
blood circulation GO:0008015 195 0.029
regulation of vesicle mediated transport GO:0060627 139 0.029
positive regulation of t cell proliferation GO:0042102 52 0.029
negative regulation of cellular component organization GO:0051129 194 0.028
modification dependent protein catabolic process GO:0019941 133 0.028
modification of morphology or physiology of other organism GO:0035821 18 0.028
dendritic cell dendrite assembly GO:0097026 2 0.028
negative regulation of secretion GO:0051048 61 0.028
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.028
spinal cord oligodendrocyte cell fate specification GO:0021530 3 0.028
positive regulation of t cell differentiation GO:0045582 52 0.028
regulation of neuron apoptotic process GO:0043523 122 0.028
positive regulation of monocyte chemotaxis GO:0090026 2 0.028
digestive tract morphogenesis GO:0048546 147 0.028
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.028
regulation of innate immune response GO:0045088 91 0.028
regulation of reproductive process GO:2000241 66 0.028
dephosphorylation GO:0016311 129 0.028
sensory system development GO:0048880 3 0.027
energy derivation by oxidation of organic compounds GO:0015980 77 0.027
myeloid cell homeostasis GO:0002262 114 0.027
regulation of cellular component biogenesis GO:0044087 181 0.027
regulation of neutrophil mediated killing of gram negative bacterium GO:0070951 1 0.027
disruption of cells of other organism GO:0044364 13 0.027
fatty acid biosynthetic process GO:0006633 41 0.027
glandular epithelial cell differentiation GO:0002067 38 0.027
phagocytosis GO:0006909 66 0.027
interleukin 5 secretion GO:0072603 2 0.027
killing by host of symbiont cells GO:0051873 11 0.027
ribose phosphate metabolic process GO:0019693 291 0.027
regulation of cell projection organization GO:0031344 206 0.027
cellular homeostasis GO:0019725 240 0.027
mesonephros development GO:0001823 97 0.026
stem cell differentiation GO:0048863 268 0.026
negative regulation of macrophage apoptotic process GO:2000110 3 0.026
ectoderm formation GO:0001705 3 0.026
cell differentiation involved in embryonic placenta development GO:0060706 26 0.026
amino acid transport GO:0006865 61 0.026
membrane organization GO:0061024 245 0.026
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 16 0.026
fatty acid transport GO:0015908 28 0.026
defense response to gram negative bacterium GO:0050829 28 0.026
endocytosis GO:0006897 168 0.026
regulation of hormone levels GO:0010817 211 0.026
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.026
divalent inorganic cation transport GO:0072511 178 0.026
autophagy GO:0006914 45 0.026
reactive nitrogen species metabolic process GO:2001057 0 0.026
regulation of cell growth GO:0001558 91 0.026
cell fate determination GO:0001709 32 0.026
organophosphate biosynthetic process GO:0090407 122 0.026
negative regulation of lipid metabolic process GO:0045833 30 0.025
t cell differentiation GO:0030217 174 0.025
carbon catabolite repression of transcription from rna polymerase ii promoter GO:0000437 1 0.025
alpha amino acid metabolic process GO:1901605 59 0.025
organic hydroxy compound metabolic process GO:1901615 203 0.025
septum transversum development GO:0003343 2 0.025
negative regulation of phosphate metabolic process GO:0045936 184 0.025
regulation of cartilage development GO:0061035 44 0.025
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.025
negative regulation of protein phosphorylation GO:0001933 126 0.025
hair cycle GO:0042633 90 0.025
regulation of myeloid cell differentiation GO:0045637 96 0.025
t cell mediated immunity GO:0002456 50 0.025
regulation of vasculature development GO:1901342 88 0.024
thymocyte migration GO:0072679 2 0.024
mammary gland lobule development GO:0061377 22 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.024
regulation of fatty acid metabolic process GO:0019217 28 0.024
transmission of nerve impulse GO:0019226 76 0.024
purine ribonucleoside metabolic process GO:0046128 241 0.024
mesangial cell differentiation GO:0072007 4 0.024
chromatin organization GO:0006325 206 0.024
paraxial mesodermal cell differentiation GO:0048342 2 0.024
small molecule catabolic process GO:0044282 71 0.024
vascular wound healing GO:0061042 3 0.024
apoptotic process involved in morphogenesis GO:0060561 25 0.024
regulation of intracellular transport GO:0032386 159 0.024
monosaccharide metabolic process GO:0005996 106 0.024
regulation of ovulation GO:0060278 3 0.024
muscle fiber development GO:0048747 76 0.024
regulation of ras gtpase activity GO:0032318 88 0.024
regulation of vitamin d biosynthetic process GO:0060556 1 0.024
chemotaxis GO:0006935 247 0.024
circadian temperature homeostasis GO:0060086 2 0.024
positive regulation vascular endothelial growth factor production GO:0010575 10 0.023
regulation of cell adhesion GO:0030155 154 0.023
positive regulation of interleukin 1 secretion GO:0050716 14 0.023
regulation of lymphocyte differentiation GO:0045619 107 0.023
fat cell differentiation GO:0045444 160 0.023
purine nucleotide catabolic process GO:0006195 211 0.023
positive regulation of lipid metabolic process GO:0045834 40 0.023
generation of precursor metabolites and energy GO:0006091 103 0.023
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.023
t helper 1 type immune response GO:0042088 25 0.023
cell cell recognition GO:0009988 44 0.023
peptidyl tyrosine phosphorylation GO:0018108 143 0.023
fat soluble vitamin biosynthetic process GO:0042362 4 0.023
cardiac chamber development GO:0003205 108 0.023
cellular response to interleukin 4 GO:0071353 21 0.023
cell maturation GO:0048469 127 0.023
bone development GO:0060348 120 0.023
guanosine containing compound catabolic process GO:1901069 144 0.023
response to growth factor GO:0070848 198 0.023
cdc42 protein signal transduction GO:0032488 0 0.022
retina morphogenesis in camera type eye GO:0060042 45 0.022
adiponectin secretion GO:0070162 2 0.022
interleukin 1 production GO:0032612 31 0.022
purine ribonucleotide metabolic process GO:0009150 290 0.022
peptide secretion GO:0002790 114 0.022
myeloid leukocyte differentiation GO:0002573 119 0.022
collagen fibril organization GO:0030199 32 0.022
mammary gland duct morphogenesis GO:0060603 38 0.022
stem cell proliferation GO:0072089 117 0.022
response to transforming growth factor beta GO:0071559 88 0.022
myeloid cell apoptotic process GO:0033028 22 0.022
positive regulation of plasminogen activation GO:0010756 2 0.022
ras protein signal transduction GO:0007265 77 0.022

Gdf15 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.092
nervous system disease DOID:863 0 0.092
sensory system disease DOID:0050155 0 0.077
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
organ system cancer DOID:0050686 0 0.024
neuropathy DOID:870 0 0.024