Mus musculus

77 known processes

Gdf5

growth differentiation factor 5

(Aliases: Cdmp-1,bp,brp)

Gdf5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
polarity specification of proximal distal axis GO:0010085 2 0.966
Mouse
skeletal system morphogenesis GO:0048705 203 0.965
Mouse
kidney epithelium development GO:0072073 121 0.959
Mouse
limb development GO:0060173 166 0.952
limb morphogenesis GO:0035108 149 0.950
negative regulation of prostatic bud formation GO:0060686 4 0.943
Mouse
forelimb morphogenesis GO:0035136 40 0.942
appendage development GO:0048736 166 0.938
cell fate commitment GO:0045165 210 0.928
Mouse
mesonephric tubule development GO:0072164 94 0.919
Mouse
urogenital system development GO:0001655 261 0.900
Mouse
embryonic limb morphogenesis GO:0030326 126 0.888
cartilage development GO:0051216 140 0.886
regulation of muscle tissue development GO:1901861 97 0.880
Mouse
forebrain development GO:0030900 302 0.866
Mouse
muscle tissue development GO:0060537 308 0.856
Mouse
skeletal system development GO:0001501 356 0.846
cell fate specification GO:0001708 72 0.842
Mouse
negative regulation of cell development GO:0010721 169 0.837
Mouse
regulation of chondrocyte differentiation GO:0032330 33 0.835
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 2 0.821
Mouse
regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis GO:0072039 4 0.818
Mouse
embryonic skeletal system development GO:0048706 120 0.797
Mouse
muscle cell development GO:0055001 133 0.792
Mouse
transforming growth factor beta receptor signaling pathway involved in primitive streak formation GO:0090010 1 0.792
Mouse
bmp signaling pathway GO:0030509 93 0.789
Mouse
male gamete generation GO:0048232 285 0.755
Mouse
tube formation GO:0035148 140 0.748
Mouse
hindlimb morphogenesis GO:0035137 42 0.739
mesodermal cell fate specification GO:0007501 11 0.728
Mouse
appendage morphogenesis GO:0035107 149 0.725
placenta development GO:0001890 140 0.720
Mouse
chondrocyte differentiation GO:0002062 72 0.708
striated muscle tissue development GO:0014706 293 0.697
Mouse
camera type eye development GO:0043010 266 0.688
Mouse
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 2 0.677
Mouse
regulation of organ morphogenesis GO:2000027 144 0.660
Mouse
regulation of cardiac muscle tissue development GO:0055024 31 0.653
Mouse
negative regulation of stem cell differentiation GO:2000737 14 0.649
Mouse
renal system development GO:0072001 225 0.639
Mouse
mesodermal cell differentiation GO:0048333 22 0.630
Mouse
endochondral bone morphogenesis GO:0060350 50 0.630
Mouse
heart morphogenesis GO:0003007 178 0.627
Mouse
positive regulation of cartilage development GO:0061036 18 0.618
stem cell proliferation GO:0072089 117 0.611
Mouse
primary neural tube formation GO:0014020 95 0.597
Mouse
kidney morphogenesis GO:0060993 83 0.595
Mouse
positive regulation of chondrocyte differentiation GO:0032332 13 0.592
tendon cell differentiation GO:0035990 4 0.592
Mouse
leukocyte differentiation GO:0002521 342 0.591
sensory organ morphogenesis GO:0090596 242 0.586
Mouse
heart trabecula formation GO:0060347 14 0.583
Mouse
somatic stem cell maintenance GO:0035019 47 0.579
Mouse
tendon formation GO:0035992 4 0.568
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.566
axial mesoderm formation GO:0048320 3 0.556
Mouse
axial mesodermal cell fate specification GO:0048327 1 0.556
Mouse
mesodermal cell fate commitment GO:0001710 17 0.555
Mouse
fat cell differentiation GO:0045444 160 0.548
Mouse
embryonic organ morphogenesis GO:0048562 276 0.548
Mouse
regionalization GO:0003002 337 0.547
Mouse
ureteric bud development GO:0001657 94 0.547
Mouse
regulation of muscle system process GO:0090257 80 0.544
Mouse
mesonephros development GO:0001823 97 0.542
Mouse
embryonic appendage morphogenesis GO:0035113 126 0.538
cellular response to growth factor stimulus GO:0071363 197 0.532
Mouse
embryonic heart tube morphogenesis GO:0003143 51 0.531
Mouse
mesenchymal cell proliferation GO:0010463 44 0.525
Mouse
regulation of neuron differentiation GO:0045664 281 0.516
Mouse
positive regulation of apoptotic process GO:0043065 217 0.513
Mouse
muscle cell proliferation GO:0033002 52 0.511
Mouse
cardiocyte differentiation GO:0035051 87 0.508
Mouse
metanephros development GO:0001656 79 0.506
Mouse
nephrogenic mesenchyme morphogenesis GO:0072134 2 0.502
Mouse
cardiac chamber morphogenesis GO:0003206 93 0.500
Mouse
positive regulation of cell death GO:0010942 224 0.491
Mouse
organ growth GO:0035265 117 0.454
Mouse Worm
regulation of bmp signaling pathway GO:0030510 60 0.451
cardiac ventricle morphogenesis GO:0003208 50 0.442
Mouse
male sex differentiation GO:0046661 109 0.439
Mouse Worm
epiblast cell extraembryonic ectoderm cell signaling involved in anterior posterior axis specification GO:0060802 1 0.436
Mouse
regulation of cardiac muscle cell proliferation GO:0060043 23 0.434
Mouse
trophectodermal cell differentiation GO:0001829 21 0.433
Mouse
kidney development GO:0001822 213 0.431
Mouse
determination of left right symmetry GO:0007368 80 0.430
Mouse
regulation of embryonic development GO:0045995 71 0.426
Mouse
left lung morphogenesis GO:0060460 3 0.417
Mouse
cardiac muscle tissue morphogenesis GO:0055008 44 0.417
Mouse
defense response to fungus GO:0050832 12 0.415
Worm
positive regulation of tendon cell differentiation GO:2001051 1 0.412
Mouse
liver development GO:0001889 66 0.412
Mouse
defense response to other organism GO:0098542 197 0.411
Worm
cell type specific apoptotic process GO:0097285 268 0.395
regulation of timing of cell differentiation GO:0048505 11 0.394
Mouse
cellular amine metabolic process GO:0044106 44 0.392
mesonephric epithelium development GO:0072163 94 0.391
Mouse
positive regulation of growth GO:0045927 104 0.385
Mouse Worm
regulation of cellular amine metabolic process GO:0033238 20 0.383
embryonic epithelial tube formation GO:0001838 130 0.382
Mouse
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.375
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.369
anatomical structure homeostasis GO:0060249 145 0.365
response to transforming growth factor beta GO:0071559 88 0.364
Mouse
trophectodermal cellular morphogenesis GO:0001831 3 0.362
Mouse
mesendoderm development GO:0048382 3 0.358
Mouse
positive regulation of muscle tissue development GO:1901863 32 0.357
Mouse
embryonic camera type eye development GO:0031076 36 0.352
Mouse
lymphocyte differentiation GO:0030098 242 0.342
midbrain development GO:0030901 35 0.340
Mouse
muscle adaptation GO:0043500 39 0.340
Mouse
eye photoreceptor cell differentiation GO:0001754 41 0.335
axonogenesis GO:0007409 274 0.334
Mouse
morphogenesis of an epithelial fold GO:0060571 28 0.334
Mouse
epithelial tube formation GO:0072175 130 0.319
Mouse
positive regulation of cell development GO:0010720 237 0.318
Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 2 0.317
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.314
regulation of heart morphogenesis GO:2000826 22 0.303
Mouse
positive regulation of programmed cell death GO:0043068 218 0.295
Mouse
cellular ketone metabolic process GO:0042180 84 0.293
metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 2 0.292
Mouse
cellular amino acid metabolic process GO:0006520 103 0.289
defense response to bacterium GO:0042742 119 0.287
Worm
atrial cardiac muscle tissue development GO:0003228 5 0.280
Mouse
muscle cell differentiation GO:0042692 261 0.279
Mouse
positive regulation of cell cycle GO:0045787 92 0.277
Worm
regulation of hydrolase activity GO:0051336 246 0.277
retinal ganglion cell axon guidance GO:0031290 18 0.275
positive regulation of cell cycle process GO:0090068 61 0.274
Worm
morphogenesis of embryonic epithelium GO:0016331 159 0.272
Mouse
neuroepithelial cell differentiation GO:0060563 37 0.272
Mouse
branching morphogenesis of an epithelial tube GO:0048754 159 0.271
Mouse
blood vessel morphogenesis GO:0048514 285 0.267
Mouse
embryonic skeletal joint morphogenesis GO:0060272 11 0.267
Mouse
digestive system development GO:0055123 200 0.263
Mouse
gland development GO:0048732 330 0.260
Mouse
lung morphogenesis GO:0060425 50 0.259
Mouse
forebrain morphogenesis GO:0048853 17 0.257
Mouse
epithelial tube morphogenesis GO:0060562 303 0.254
Mouse
axial mesodermal cell fate commitment GO:0048322 1 0.254
Mouse
inhibition of neuroepithelial cell differentiation GO:0002085 2 0.254
Mouse
embryonic eye morphogenesis GO:0048048 29 0.249
Mouse
digestive tract development GO:0048565 190 0.248
Mouse
retina development in camera type eye GO:0060041 119 0.248
blastocyst development GO:0001824 80 0.246
Mouse
kidney mesenchyme morphogenesis GO:0072131 4 0.246
Mouse
regulation of muscle adaptation GO:0043502 31 0.244
Mouse
odontogenesis GO:0042476 78 0.241
Mouse
tissue homeostasis GO:0001894 115 0.240
regulation of reproductive process GO:2000241 66 0.240
Mouse
regulation of epithelial cell proliferation GO:0050678 141 0.233
Human Mouse
mesenchyme morphogenesis GO:0072132 32 0.228
Mouse
positive regulation of epithelial cell proliferation GO:0050679 68 0.226
Mouse
regulation of cardiac muscle tissue growth GO:0055021 26 0.225
Mouse
mesenchymal stem cell maintenance involved in nephron morphogenesis GO:0072038 7 0.224
Mouse
digestive tract morphogenesis GO:0048546 147 0.222
Mouse
salivary gland morphogenesis GO:0007435 33 0.222
Mouse
morphogenesis of an epithelial bud GO:0060572 18 0.221
Mouse
embryonic skeletal system morphogenesis GO:0048704 91 0.218
Mouse
cardiac chamber development GO:0003205 108 0.212
Mouse
trabecula formation GO:0060343 24 0.212
Mouse
regulation of cellular response to stress GO:0080135 159 0.209
photoreceptor cell differentiation GO:0046530 52 0.207
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.207
Mouse
positive regulation of dna endoreduplication GO:0032877 2 0.203
Worm
respiratory tube development GO:0030323 167 0.203
Mouse
negative regulation of kidney development GO:0090185 15 0.203
Mouse
muscle system process GO:0003012 141 0.203
Mouse
negative regulation of cell proliferation GO:0008285 296 0.202
Human Mouse
branching involved in prostate gland morphogenesis GO:0060442 15 0.200
Mouse
hepaticobiliary system development GO:0061008 67 0.200
Mouse
regulation of lymphocyte activation GO:0051249 240 0.200
ossification GO:0001503 216 0.196
Mouse
nephron epithelium development GO:0072009 92 0.196
cell adhesion GO:0007155 329 0.194
skeletal muscle organ development GO:0060538 163 0.193
negative regulation of stem cell maintenance GO:1902455 4 0.189
Mouse
regulation of apoptotic signaling pathway GO:2001233 197 0.188
formation of primary germ layer GO:0001704 77 0.187
Mouse
branching involved in salivary gland morphogenesis GO:0060445 26 0.186
Mouse
gastrulation GO:0007369 116 0.186
Mouse
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.185
Mouse
regulation of dna endoreduplication GO:0032875 3 0.184
Worm
dna metabolic process GO:0006259 303 0.183
Worm
cardiac ventricle development GO:0003231 83 0.182
Mouse
prostate gland morphogenesis GO:0060512 32 0.180
Mouse
response to dietary excess GO:0002021 18 0.179
Mouse
roof plate formation GO:0021509 1 0.179
Mouse
positive regulation of neuron differentiation GO:0045666 141 0.178
Mouse
heart trabecula morphogenesis GO:0061384 26 0.175
Mouse
cardiac muscle tissue development GO:0048738 130 0.175
Mouse
prostate gland development GO:0030850 48 0.174
Mouse
negative regulation of neuron death GO:1901215 98 0.173
innate immune response GO:0045087 157 0.172
Worm
amine metabolic process GO:0009308 45 0.172
skeletal muscle fiber development GO:0048741 58 0.168
apoptotic signaling pathway GO:0097190 306 0.165
positive regulation of receptor activity GO:2000273 17 0.165
Mouse
regulation of cardiac muscle hypertrophy GO:0010611 13 0.164
Mouse
regulation of organ formation GO:0003156 34 0.163
Mouse
endoderm development GO:0007492 45 0.163
Mouse
respiratory system development GO:0060541 190 0.162
Mouse
iron ion homeostasis GO:0055072 36 0.157
Mouse
regulation of morphogenesis of a branching structure GO:0060688 53 0.154
Mouse
embryonic process involved in female pregnancy GO:0060136 7 0.153
Mouse
negative regulation of embryonic development GO:0045992 22 0.152
Mouse
energy homeostasis GO:0097009 15 0.151
Mouse
positive regulation of cardiac muscle tissue growth GO:0055023 15 0.149
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 220 0.149
morphogenesis of a branching epithelium GO:0061138 193 0.148
Mouse
cellular transition metal ion homeostasis GO:0046916 32 0.147
Mouse
cardiac muscle cell development GO:0055013 39 0.147
Mouse
metanephric mesenchyme morphogenesis GO:0072133 4 0.147
Mouse
alcohol metabolic process GO:0006066 116 0.146
germ cell development GO:0007281 185 0.146
Mouse
regulation of muscle hypertrophy GO:0014743 13 0.143
Mouse
nodal signaling pathway GO:0038092 10 0.142
Mouse
regulation of mapk cascade GO:0043408 248 0.142
Mouse
ureteric bud morphogenesis GO:0060675 62 0.142
cell proliferation involved in metanephros development GO:0072203 9 0.141
Mouse
cellular iron ion homeostasis GO:0006879 16 0.139
Mouse
homeostasis of number of cells GO:0048872 210 0.138
developmental maturation GO:0021700 193 0.138
dna replication GO:0006260 52 0.137
Worm
left lung development GO:0060459 4 0.136
Mouse
smad protein signal transduction GO:0060395 21 0.136
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.135
Mouse
positive regulation of angiogenesis GO:0045766 46 0.135
Mouse
nephron development GO:0072006 109 0.134
Mouse
nephron tubule development GO:0072080 84 0.133
epithelial cell proliferation GO:0050673 174 0.132
Human Mouse
nail development GO:0035878 5 0.131
embryonic digit morphogenesis GO:0042733 56 0.129
regulation of tendon cell differentiation GO:2001049 1 0.128
Mouse
kidney mesenchymal cell proliferation GO:0072135 2 0.127
Mouse
positive regulation of nervous system development GO:0051962 221 0.127
Mouse
embryonic placenta development GO:0001892 98 0.126
Mouse
metanephros morphogenesis GO:0003338 24 0.126
myotube differentiation GO:0014902 105 0.126
central nervous system neuron differentiation GO:0021953 162 0.125
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.124
Mouse
multicellular organismal homeostasis GO:0048871 164 0.124
Mouse
regulation of cell cycle GO:0051726 281 0.123
Worm
connective tissue development GO:0061448 179 0.122
regulation of vasculature development GO:1901342 88 0.122
Mouse
retina homeostasis GO:0001895 23 0.120
negative regulation of cellular amine metabolic process GO:0033239 1 0.118
regulation of cellular ketone metabolic process GO:0010565 66 0.118
striated muscle cell proliferation GO:0014855 39 0.117
Mouse
negative regulation of reproductive process GO:2000242 31 0.117
Mouse
nephron morphogenesis GO:0072028 69 0.117
Mouse
spermatid differentiation GO:0048515 115 0.115
male genitalia development GO:0030539 20 0.114
Mouse
response to extracellular stimulus GO:0009991 127 0.113
Mouse
protein maturation GO:0051604 176 0.113
mesoderm development GO:0007498 100 0.112
Mouse
stem cell development GO:0048864 219 0.111
Mouse
stem cell maintenance GO:0019827 130 0.110
Mouse
cytokine production GO:0001816 319 0.110
regulation of gastrulation GO:0010470 16 0.107
Mouse
mesenchymal cell apoptotic process GO:0097152 14 0.106
response to nutrient levels GO:0031667 109 0.106
Mouse
muscle tissue morphogenesis GO:0060415 53 0.106
Mouse
regulation of cell proliferation involved in heart morphogenesis GO:2000136 15 0.106
Mouse
brain morphogenesis GO:0048854 32 0.106
Mouse
regulation of anatomical structure size GO:0090066 178 0.105
Worm
regulation of heart growth GO:0060420 31 0.105
Mouse
neural fold formation GO:0001842 7 0.104
Mouse
endodermal cell fate specification GO:0001714 4 0.102
metanephric mesenchyme development GO:0072075 10 0.102
Mouse
cellular chemical homeostasis GO:0055082 215 0.101
Mouse
positive regulation of cell activation GO:0050867 158 0.101
regulation of protein processing GO:0070613 96 0.101
positive regulation of bmp signaling pathway GO:0030513 23 0.100
primitive streak formation GO:0090009 10 0.100
Mouse
regulation of b cell activation GO:0050864 81 0.100
regulation of protein localization GO:0032880 231 0.100
rho protein signal transduction GO:0007266 32 0.099
purine nucleoside catabolic process GO:0006152 205 0.099
asymmetric stem cell division GO:0098722 3 0.098
axis elongation involved in somitogenesis GO:0090245 4 0.098
cell proliferation involved in heart morphogenesis GO:0061323 15 0.097
Mouse
spinal cord association neuron differentiation GO:0021527 14 0.097
Mouse
diet induced thermogenesis GO:0002024 7 0.096
Mouse
kidney mesenchyme development GO:0072074 14 0.096
Mouse
positive regulation of protein modification process GO:0031401 299 0.095
Mouse
apoptotic process involved in morphogenesis GO:0060561 25 0.095
Mouse
regulation of receptor activity GO:0010469 41 0.095
Mouse
regulation of binding GO:0051098 111 0.094
organic cyclic compound catabolic process GO:1901361 295 0.094
lens morphogenesis in camera type eye GO:0002089 24 0.093
t cell differentiation GO:0030217 174 0.093
myeloid cell differentiation GO:0030099 233 0.093
cell differentiation in spinal cord GO:0021515 53 0.093
Mouse
retina morphogenesis in camera type eye GO:0060042 45 0.092
lateral mesoderm development GO:0048368 13 0.092
Mouse
positive regulation of striated muscle tissue development GO:0045844 31 0.091
Mouse
formation of anatomical boundary GO:0048859 6 0.090
Mouse
negative regulation of proteolysis GO:0045861 74 0.090
mesenchyme development GO:0060485 152 0.090
Mouse
neuron projection guidance GO:0097485 141 0.090
Mouse
glial cell differentiation GO:0010001 131 0.089
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.088
dorsal spinal cord development GO:0021516 20 0.087
Mouse
lens development in camera type eye GO:0002088 62 0.087
positive regulation of organ growth GO:0046622 29 0.087
Mouse Worm
regulation of apoptotic process involved in morphogenesis GO:1902337 10 0.087
Mouse
mapk cascade GO:0000165 281 0.085
Mouse
pallium development GO:0021543 120 0.085
myotube cell development GO:0014904 60 0.084
regulation of chloride transport GO:2001225 2 0.084
endothelial cell morphogenesis GO:0001886 9 0.084
skeletal muscle cell differentiation GO:0035914 66 0.082
small gtpase mediated signal transduction GO:0007264 97 0.082
transition metal ion homeostasis GO:0055076 54 0.082
Mouse
synaptic transmission GO:0007268 329 0.082
regulation of cell activation GO:0050865 289 0.082
lymphocyte proliferation GO:0046651 164 0.082
asymmetric neuroblast division GO:0055059 1 0.081
peptidyl tyrosine phosphorylation GO:0018108 143 0.081
endothelial cell differentiation GO:0045446 41 0.080
Mouse
embryonic retina morphogenesis in camera type eye GO:0060059 7 0.080
t cell activation GO:0042110 289 0.080
epithelial cell development GO:0002064 159 0.078
protein processing GO:0016485 163 0.077
regulation of secretion GO:0051046 274 0.075
axis elongation GO:0003401 30 0.075
anion transport GO:0006820 177 0.074
camera type eye photoreceptor cell differentiation GO:0060219 15 0.074
positive regulation of protein kinase activity GO:0045860 144 0.074
positive regulation of endothelial cell differentiation GO:0045603 7 0.072
Mouse
regulation of cell size GO:0008361 72 0.072
Worm
telencephalon development GO:0021537 186 0.071
spermatogenesis GO:0007283 284 0.071
Mouse
regulation of mesenchymal cell proliferation GO:0010464 37 0.070
artery development GO:0060840 53 0.069
regulation of cartilage development GO:0061035 44 0.069
cellular homeostasis GO:0019725 240 0.069
Mouse
purine containing compound metabolic process GO:0072521 311 0.068
developmental growth involved in morphogenesis GO:0060560 138 0.068
axial mesoderm morphogenesis GO:0048319 5 0.067
Mouse
bone morphogenesis GO:0060349 78 0.067
Mouse
multicellular organism growth GO:0035264 161 0.067
heart growth GO:0060419 45 0.067
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.066
cardiac cell development GO:0055006 41 0.066
Mouse
wnt signaling pathway calcium modulating pathway GO:0007223 2 0.066
striated muscle hypertrophy GO:0014897 24 0.065
Mouse
wnt signaling pathway GO:0016055 188 0.065
replacement ossification GO:0036075 26 0.065
Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.064
neural retina development GO:0003407 41 0.064
ras protein signal transduction GO:0007265 77 0.064
atrial cardiac muscle tissue morphogenesis GO:0055009 5 0.064
Mouse
cochlea development GO:0090102 35 0.064
cell division GO:0051301 120 0.063
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.063
purine ribonucleoside metabolic process GO:0046128 241 0.063
ventricular cardiac muscle cell differentiation GO:0055012 17 0.063
Mouse
endothelial cell development GO:0001885 20 0.063
cellular ion homeostasis GO:0006873 165 0.063
Mouse
cardiac muscle tissue growth GO:0055017 37 0.062
Mouse
multi multicellular organism process GO:0044706 109 0.062
Mouse
regulation of homeostatic process GO:0032844 182 0.062
Mouse
mesenchymal cell development GO:0014031 93 0.061
ameboidal type cell migration GO:0001667 128 0.061
Mouse
ventricular cardiac muscle cell development GO:0055015 11 0.060
Mouse
smoothened signaling pathway GO:0007224 105 0.060
positive regulation of cardiac muscle cell proliferation GO:0060045 15 0.060
Mouse
negative regulation of apoptotic signaling pathway GO:2001234 104 0.060
negative regulation of cellular protein metabolic process GO:0032269 247 0.060
b cell activation GO:0042113 161 0.059
cardiac muscle hypertrophy GO:0003300 23 0.059
Mouse
nucleoside metabolic process GO:0009116 246 0.058
endocytosis GO:0006897 168 0.058
embryonic genitalia morphogenesis GO:0030538 4 0.058
regulation of t cell activation GO:0050863 170 0.058
organic hydroxy compound biosynthetic process GO:1901617 77 0.056
regulation of rho protein signal transduction GO:0035023 71 0.056
cellular metal ion homeostasis GO:0006875 151 0.056
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.056
extracellular structure organization GO:0043062 148 0.054
positive regulation of neuron projection regeneration GO:0070572 2 0.054
response to organonitrogen compound GO:0010243 246 0.054
nephron epithelium morphogenesis GO:0072088 68 0.054
regulation of stem cell differentiation GO:2000736 50 0.053
Mouse
regulation of dna replication GO:0006275 17 0.053
Worm
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.053
negative regulation of protein metabolic process GO:0051248 282 0.053
regulation of neuron death GO:1901214 134 0.053
chemotaxis GO:0006935 247 0.052
Mouse
gastrulation with mouth forming second GO:0001702 29 0.052
Mouse
ventricular cardiac muscle tissue development GO:0003229 38 0.052
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.052
negative regulation of immune system process GO:0002683 209 0.052
palate development GO:0060021 76 0.051
nucleoside triphosphate metabolic process GO:0009141 230 0.051
positive regulation of cellular component biogenesis GO:0044089 94 0.051
regulation of cell motility GO:2000145 236 0.050
nucleoside phosphate metabolic process GO:0006753 338 0.050
defense response to gram positive bacterium GO:0050830 50 0.050
Worm
cardiac atrium morphogenesis GO:0003209 23 0.050
Mouse
establishment of tissue polarity GO:0007164 28 0.050
regulation of purine nucleotide metabolic process GO:1900542 169 0.049
negative regulation of muscle hypertrophy GO:0014741 9 0.049
Mouse
actin cytoskeleton organization GO:0030036 220 0.049
macromolecule catabolic process GO:0009057 281 0.049
hair follicle development GO:0001942 85 0.049
mesenchymal cell proliferation involved in ureter development GO:0072198 4 0.048
cartilage condensation GO:0001502 18 0.048
single organismal cell cell adhesion GO:0016337 131 0.048
b cell differentiation GO:0030183 78 0.048
peptidyl amino acid modification GO:0018193 336 0.048
renal tubule morphogenesis GO:0061333 72 0.048
limbic system development GO:0021761 72 0.048
stress activated mapk cascade GO:0051403 80 0.048
pathway restricted smad protein phosphorylation GO:0060389 10 0.047
Mouse
cell cell junction organization GO:0045216 72 0.047
regulation of cellular component biogenesis GO:0044087 181 0.047
purine nucleotide metabolic process GO:0006163 302 0.047
negative regulation of neuron differentiation GO:0045665 101 0.046
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.046
protein modification by small protein conjugation GO:0032446 187 0.046
diencephalon development GO:0021536 63 0.045
striated muscle cell development GO:0055002 125 0.045
Mouse
positive regulation of osteoblast differentiation GO:0045669 34 0.045
negative regulation of hydrolase activity GO:0051346 71 0.045
regulation of cell substrate adhesion GO:0010810 73 0.045
glycosyl compound catabolic process GO:1901658 206 0.045
regulation of peptidase activity GO:0052547 96 0.044
regulation of lymphocyte differentiation GO:0045619 107 0.044
positive regulation of endothelial cell proliferation GO:0001938 17 0.044
Mouse
cell substrate adhesion GO:0031589 130 0.044
somitogenesis GO:0001756 69 0.044
rac protein signal transduction GO:0016601 13 0.044
positive regulation of lymphocyte activation GO:0051251 140 0.043
ribonucleoside metabolic process GO:0009119 245 0.043
dna dependent dna replication GO:0006261 24 0.043
Worm
positive regulation of stem cell proliferation GO:2000648 59 0.042
cardiac muscle cell proliferation GO:0060038 31 0.042
Mouse
cardiac atrium development GO:0003230 24 0.042
Mouse
interspecies interaction between organisms GO:0044419 83 0.042
negative regulation of nervous system development GO:0051961 156 0.042
Mouse
chondrocyte development GO:0002063 24 0.042
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.041
Mouse
renal vesicle induction GO:0072034 3 0.041
heterocycle catabolic process GO:0046700 280 0.041
regulation of protein maturation GO:1903317 96 0.041
intestinal epithelial structure maintenance GO:0060729 4 0.041
ribose phosphate metabolic process GO:0019693 291 0.041
positive regulation of cell growth GO:0030307 33 0.040
cellular response to external stimulus GO:0071496 88 0.040
hematopoietic stem cell proliferation GO:0071425 13 0.040
negative regulation of cardiac muscle hypertrophy GO:0010614 9 0.040
Mouse
hypophysis morphogenesis GO:0048850 3 0.040
retinal cone cell differentiation GO:0042670 8 0.040
alpha beta t cell differentiation GO:0046632 69 0.040
peptidyl tyrosine modification GO:0018212 145 0.039
neural tube formation GO:0001841 108 0.039
Mouse
regulation of endopeptidase activity GO:0052548 89 0.039
transmembrane transport GO:0055085 412 0.039
tube closure GO:0060606 91 0.039
defense response to gram negative bacterium GO:0050829 28 0.039
Worm
regulation of stem cell proliferation GO:0072091 78 0.039
organonitrogen compound biosynthetic process GO:1901566 192 0.039
purine nucleoside triphosphate metabolic process GO:0009144 226 0.039
g protein coupled receptor signaling pathway GO:0007186 243 0.039
renal vesicle morphogenesis GO:0072077 15 0.038
negative regulation of cell fate specification GO:0009996 4 0.038
negative regulation of neuron apoptotic process GO:0043524 92 0.038
muscle fiber development GO:0048747 76 0.038
cerebellum development GO:0021549 77 0.038
regulation of neuron projection development GO:0010975 169 0.037
organic hydroxy compound metabolic process GO:1901615 203 0.037
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.037
regulation of angiogenesis GO:0045765 81 0.037
Mouse
tissue remodeling GO:0048771 102 0.037
inner ear morphogenesis GO:0042472 101 0.037
protein catabolic process GO:0030163 221 0.037
negative regulation of endopeptidase activity GO:0010951 44 0.036
regulation of organelle organization GO:0033043 289 0.036
metanephric loop of henle development GO:0072236 4 0.036
positive regulation of ossification GO:0045778 47 0.036
nucleotide metabolic process GO:0009117 332 0.036

Gdf5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 0 0.747
Human
disease of anatomical entity DOID:7 0 0.747
Human
musculoskeletal system disease DOID:17 0 0.747
Human
connective tissue disease DOID:65 0 0.747
Human
brachydactyly DOID:0050581 0 0.343
Human
bone development disease DOID:0080006 0 0.343
Human
dysostosis DOID:1934 0 0.343
Human
sensory system disease DOID:0050155 0 0.246
nervous system disease DOID:863 0 0.246
eye and adnexa disease DOID:1492 0 0.160
eye disease DOID:5614 0 0.110
retinal disease DOID:5679 0 0.093
physical disorder DOID:0080015 0 0.082