|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
14 |
1.000
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
170 |
1.000
|
Fly |
|
|
fibroblast growth factor receptor signaling pathway
|
GO:0008543 |
46 |
1.000
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
20 |
1.000
|
|
|
|
regulation of mast cell activation
|
GO:0033003 |
21 |
1.000
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
248 |
1.000
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
247 |
1.000
|
|
|
|
regulation of antigen receptor mediated signaling pathway
|
GO:0050854 |
29 |
1.000
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
77 |
0.999
|
Fly |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
97 |
0.999
|
Fly |
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
17 |
0.999
|
Fly |
|
|
regulation of kinase activity
|
GO:0043549 |
249 |
0.999
|
Fly |
|
|
cellular ketone metabolic process
|
GO:0042180 |
84 |
0.999
|
|
|
|
regulation of epidermal growth factor activated receptor activity
|
GO:0007176 |
7 |
0.999
|
Fly |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
71 |
0.998
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
41 |
0.998
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
32 |
0.997
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.996
|
|
|
|
activation of immune response
|
GO:0002253 |
138 |
0.996
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
263 |
0.995
|
Fly |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
144 |
0.995
|
|
|
|
activation of rac gtpase activity
|
GO:0032863 |
2 |
0.995
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
84 |
0.995
|
|
|
|
mapk cascade
|
GO:0000165 |
281 |
0.994
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
120 |
0.994
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
77 |
0.994
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
49 |
0.993
|
Human |
|
|
regulation of mast cell activation involved in immune response
|
GO:0033006 |
17 |
0.993
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
144 |
0.993
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
155 |
0.992
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
116 |
0.991
|
|
|
|
protein kinase b signaling
|
GO:0043491 |
74 |
0.990
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
80 |
0.989
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
114 |
0.989
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
232 |
0.988
|
Fly |
|
|
activation of mapk activity
|
GO:0000187 |
59 |
0.987
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
144 |
0.986
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
342 |
0.985
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
167 |
0.984
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
58 |
0.984
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
78 |
0.984
|
Human |
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
0 |
0.981
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
106 |
0.980
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
21 |
0.979
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
166 |
0.979
|
Fly |
|
|
regulation of mast cell degranulation
|
GO:0043304 |
16 |
0.979
|
|
|
|
negative regulation of ras protein signal transduction
|
GO:0046580 |
18 |
0.978
|
|
|
|
carbohydrate derivative catabolic process
|
GO:1901136 |
231 |
0.978
|
|
|
|
response to growth factor
|
GO:0070848 |
198 |
0.976
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
157 |
0.973
|
|
|
|
response to fibroblast growth factor
|
GO:0071774 |
47 |
0.973
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
21 |
0.972
|
|
|
|
gtp catabolic process
|
GO:0006184 |
143 |
0.969
|
|
|
|
response to peptide hormone
|
GO:0043434 |
127 |
0.968
|
Human |
|
|
b cell receptor signaling pathway
|
GO:0050853 |
20 |
0.966
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
72 |
0.965
|
|
|
|
amine metabolic process
|
GO:0009308 |
45 |
0.964
|
|
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
21 |
0.963
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
28 |
0.961
|
Fly |
|
|
organophosphate catabolic process
|
GO:0046434 |
232 |
0.960
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
156 |
0.960
|
|
|
|
cell cell signaling involved in cell fate commitment
|
GO:0045168 |
35 |
0.959
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
125 |
0.959
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
148 |
0.959
|
|
|
|
negative regulation of epidermal growth factor activated receptor activity
|
GO:0007175 |
3 |
0.959
|
Fly |
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
1 |
0.957
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
122 |
0.957
|
|
|
|
mast cell degranulation
|
GO:0043303 |
19 |
0.956
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
139 |
0.956
|
|
|
|
activation of ras gtpase activity
|
GO:0032856 |
11 |
0.956
|
|
|
|
lysosome localization
|
GO:0032418 |
20 |
0.953
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
184 |
0.953
|
Fly |
|
|
mast cell activation
|
GO:0045576 |
27 |
0.952
|
|
|
|
purine nucleotide metabolic process
|
GO:0006163 |
302 |
0.951
|
|
|
|
erbb signaling pathway
|
GO:0038127 |
32 |
0.950
|
Fly |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
145 |
0.948
|
Fly |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
65 |
0.947
|
|
|
|
olfactory learning
|
GO:0008355 |
2 |
0.945
|
Fly |
|
|
negative regulation of kinase activity
|
GO:0033673 |
81 |
0.945
|
Fly |
|
|
regulation of lymphocyte differentiation
|
GO:0045619 |
107 |
0.944
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
85 |
0.942
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
206 |
0.941
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
84 |
0.938
|
|
|
|
activation of innate immune response
|
GO:0002218 |
56 |
0.935
|
|
|
|
regulation of cellular catabolic process
|
GO:0031329 |
242 |
0.935
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
30 |
0.933
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
220 |
0.931
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
85 |
0.930
|
|
|
|
regulation of b cell differentiation
|
GO:0045577 |
23 |
0.930
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
159 |
0.926
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
143 |
0.925
|
Fly |
|
|
gtp metabolic process
|
GO:0046039 |
144 |
0.922
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
61 |
0.918
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
242 |
0.917
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
184 |
0.916
|
Fly |
|
|
negative regulation of cell activation
|
GO:0050866 |
111 |
0.913
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
205 |
0.907
|
|
|
|
regulation of receptor activity
|
GO:0010469 |
41 |
0.907
|
Fly |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
131 |
0.906
|
|
|
|
spermatid differentiation
|
GO:0048515 |
115 |
0.905
|
|
|
|
b cell differentiation
|
GO:0030183 |
78 |
0.901
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
17 |
0.899
|
Fly |
|
|
actin polymerization or depolymerization
|
GO:0008154 |
54 |
0.899
|
|
|
|
regulation of glutamate receptor signaling pathway
|
GO:1900449 |
16 |
0.894
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
44 |
0.893
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
172 |
0.891
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
199 |
0.886
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
88 |
0.885
|
|
|
|
positive regulation of mast cell degranulation
|
GO:0043306 |
10 |
0.884
|
|
|
|
organic cyclic compound catabolic process
|
GO:1901361 |
295 |
0.881
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
88 |
0.881
|
|
|
|
positive regulation of protein modification process
|
GO:0031401 |
299 |
0.874
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
42 |
0.871
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
117 |
0.871
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
240 |
0.870
|
|
|
|
negative regulation of lymphocyte proliferation
|
GO:0050672 |
45 |
0.870
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
145 |
0.869
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
282 |
0.868
|
Fly |
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
56 |
0.868
|
|
|
|
purine ribonucleotide metabolic process
|
GO:0009150 |
290 |
0.862
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
41 |
0.861
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
64 |
0.853
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
65 |
0.853
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
103 |
0.848
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
247 |
0.848
|
Fly |
|
|
nucleoside metabolic process
|
GO:0009116 |
246 |
0.846
|
|
|
|
cellular response to peptide
|
GO:1901653 |
92 |
0.845
|
Human |
|
|
lymphocyte proliferation
|
GO:0046651 |
164 |
0.842
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
230 |
0.840
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
220 |
0.840
|
|
|
|
positive regulation of leukocyte degranulation
|
GO:0043302 |
10 |
0.836
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
77 |
0.834
|
|
|
|
activation of rho gtpase activity
|
GO:0032862 |
7 |
0.829
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
113 |
0.827
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
66 |
0.824
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
205 |
0.823
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
159 |
0.821
|
|
|
|
organonitrogen compound catabolic process
|
GO:1901565 |
264 |
0.821
|
|
|
|
regulation of phosphatidylinositol 3 kinase activity
|
GO:0043551 |
14 |
0.821
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
170 |
0.815
|
|
|
|
negative regulation of receptor activity
|
GO:2000272 |
5 |
0.812
|
Fly |
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
88 |
0.811
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
246 |
0.810
|
Human |
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
130 |
0.808
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
242 |
0.807
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
34 |
0.802
|
|
|
|
cell adhesion
|
GO:0007155 |
329 |
0.801
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
217 |
0.800
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
69 |
0.788
|
|
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
47 |
0.786
|
|
|
|
regulation of ion transport
|
GO:0043269 |
215 |
0.785
|
|
|
|
t cell proliferation
|
GO:0042098 |
120 |
0.780
|
|
|
|
synaptic vesicle recycling
|
GO:0036465 |
19 |
0.776
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
159 |
0.773
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
92 |
0.770
|
|
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
32 |
0.768
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
206 |
0.766
|
|
|
|
response to oxidative stress
|
GO:0006979 |
123 |
0.765
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.763
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
281 |
0.762
|
|
|
|
lateral inhibition
|
GO:0046331 |
1 |
0.757
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
181 |
0.755
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
169 |
0.742
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
99 |
0.741
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
93 |
0.735
|
Fly |
|
|
negative regulation of transferase activity
|
GO:0051348 |
85 |
0.723
|
Fly |
|
|
negative regulation of protein tyrosine kinase activity
|
GO:0061099 |
3 |
0.723
|
Fly |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
208 |
0.717
|
|
|
|
ribonucleotide metabolic process
|
GO:0009259 |
291 |
0.711
|
|
|
|
negative regulation of erbb signaling pathway
|
GO:1901185 |
7 |
0.711
|
Fly |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
199 |
0.705
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
62 |
0.705
|
|
|
|
negative regulation of epidermal growth factor receptor signaling pathway
|
GO:0042059 |
6 |
0.701
|
Fly |
|
|
mitotic cell cycle
|
GO:0000278 |
195 |
0.701
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
81 |
0.700
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
211 |
0.700
|
|
|
|
regulation of t cell differentiation
|
GO:0045580 |
83 |
0.697
|
|
|
|
neurotrophin signaling pathway
|
GO:0038179 |
12 |
0.697
|
|
|
|
b cell homeostasis
|
GO:0001782 |
34 |
0.694
|
|
|
|
regulation of cell activation
|
GO:0050865 |
289 |
0.691
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
209 |
0.689
|
|
|
|
synaptic vesicle localization
|
GO:0097479 |
59 |
0.688
|
|
|
|
innate immune response activating signal transduction
|
GO:0002758 |
50 |
0.685
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
47 |
0.684
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
32 |
0.681
|
|
|
|
rac protein signal transduction
|
GO:0016601 |
13 |
0.675
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
160 |
0.671
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
128 |
0.668
|
|
|
|
cytokinesis
|
GO:0000910 |
17 |
0.664
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
83 |
0.662
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
46 |
0.662
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
126 |
0.655
|
|
|
|
regulation of hydrolase activity
|
GO:0051336 |
246 |
0.647
|
|
|
|
morphogenesis of a polarized epithelium
|
GO:0001738 |
37 |
0.646
|
|
|
|
urogenital system development
|
GO:0001655 |
261 |
0.630
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
206 |
0.628
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
130 |
0.628
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
74 |
0.627
|
|
|
|
regulation of n methyl d aspartate selective glutamate receptor activity
|
GO:2000310 |
10 |
0.622
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
155 |
0.622
|
|
|
|
t cell differentiation
|
GO:0030217 |
174 |
0.621
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
5 |
0.614
|
|
|
|
neurotrophin trk receptor signaling pathway
|
GO:0048011 |
8 |
0.612
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
163 |
0.612
|
Fly |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
203 |
0.607
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
61 |
0.604
|
|
|
|
homotypic cell cell adhesion
|
GO:0034109 |
28 |
0.602
|
|
|
|
nucleobase containing small molecule metabolic process
|
GO:0055086 |
352 |
0.598
|
|
|
|
positive regulation of lipid kinase activity
|
GO:0090218 |
11 |
0.596
|
|
|
|
spermatid development
|
GO:0007286 |
108 |
0.589
|
|
|
|
nucleotide metabolic process
|
GO:0009117 |
332 |
0.589
|
|
|
|
mast cell mediated immunity
|
GO:0002448 |
20 |
0.586
|
|
|
|
regulation of organ morphogenesis
|
GO:2000027 |
144 |
0.581
|
Fly |
|
|
myeloid cell activation involved in immune response
|
GO:0002275 |
34 |
0.576
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
60 |
0.566
|
|
|
|
neuron neuron synaptic transmission
|
GO:0007270 |
69 |
0.566
|
|
|
|
t cell activation
|
GO:0042110 |
289 |
0.564
|
Mouse |
|
|
regulation of cell projection organization
|
GO:0031344 |
206 |
0.564
|
Worm |
|
|
activation of mapk activity involved in innate immune response
|
GO:0035419 |
2 |
0.563
|
|
|
|
regulation of protein localization
|
GO:0032880 |
231 |
0.561
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
126 |
0.559
|
Fly |
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
20 |
0.556
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
19 |
0.556
|
|
|
|
negative regulation of protein kinase b signaling
|
GO:0051898 |
18 |
0.552
|
|
|
|
immune effector process
|
GO:0002252 |
321 |
0.552
|
|
|
|
endocytosis
|
GO:0006897 |
168 |
0.550
|
Human Yeast Worm |
|
|
prostate gland development
|
GO:0030850 |
48 |
0.550
|
|
|
|
sensory organ morphogenesis
|
GO:0090596 |
242 |
0.550
|
Fly |
|
|
positive regulation of myeloid leukocyte mediated immunity
|
GO:0002888 |
14 |
0.548
|
|
|
|
regulation of lipid kinase activity
|
GO:0043550 |
14 |
0.544
|
|
|
|
optic placode formation involved in camera type eye formation
|
GO:0046619 |
2 |
0.542
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
150 |
0.538
|
Human |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
222 |
0.535
|
|
|
|
activation of jun kinase activity
|
GO:0007257 |
15 |
0.535
|
|
|
|
neural precursor cell proliferation
|
GO:0061351 |
121 |
0.532
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
20 |
0.531
|
|
|
|
t cell anergy
|
GO:0002870 |
4 |
0.529
|
|
|
|
developmental induction
|
GO:0031128 |
34 |
0.527
|
|
|
|
innate immune response
|
GO:0045087 |
157 |
0.526
|
|
|
|
heterocycle catabolic process
|
GO:0046700 |
280 |
0.526
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
124 |
0.526
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
220 |
0.523
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
9 |
0.520
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
30 |
0.515
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
71 |
0.514
|
|
|
|
membrane fusion
|
GO:0061025 |
38 |
0.511
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
91 |
0.510
|
|
|
|
positive regulation of regulated secretory pathway
|
GO:1903307 |
10 |
0.508
|
|
|
|
cell junction maintenance
|
GO:0034331 |
4 |
0.506
|
|
|
|
regionalization
|
GO:0003002 |
337 |
0.502
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
266 |
0.502
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
61 |
0.500
|
|
|
|
exocytosis
|
GO:0006887 |
121 |
0.498
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
296 |
0.497
|
|
|
|
positive regulation of exocytosis
|
GO:0045921 |
20 |
0.496
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
64 |
0.496
|
|
|
|
negative regulation of insulin receptor signaling pathway
|
GO:0046627 |
14 |
0.493
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
5 |
0.493
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
87 |
0.490
|
|
|
|
integrin mediated signaling pathway
|
GO:0007229 |
27 |
0.490
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
41 |
0.489
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
169 |
0.485
|
|
|
|
positive regulation of mast cell activation involved in immune response
|
GO:0033008 |
10 |
0.484
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
70 |
0.481
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
122 |
0.472
|
|
|
|
extracellular structure organization
|
GO:0043062 |
148 |
0.466
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
53 |
0.466
|
|
|
|
regulation of g1 s transition of mitotic cell cycle
|
GO:2000045 |
35 |
0.465
|
|
|
|
vesicle organization
|
GO:0016050 |
60 |
0.454
|
|
|
|
positive regulation of phospholipase c activity
|
GO:0010863 |
2 |
0.451
|
|
|
|
negative regulation of leukocyte proliferation
|
GO:0070664 |
46 |
0.448
|
|
|
|
cellularization
|
GO:0007349 |
1 |
0.445
|
|
|
|
synaptic vesicle transport
|
GO:0048489 |
57 |
0.443
|
|
|
|
negative regulation of b cell receptor signaling pathway
|
GO:0050859 |
4 |
0.440
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
112 |
0.439
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
164 |
0.438
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
83 |
0.438
|
|
|
|
optic placode formation
|
GO:0001743 |
2 |
0.438
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
92 |
0.437
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
122 |
0.437
|
|
|
|
synaptic vesicle membrane organization
|
GO:0048499 |
1 |
0.435
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
80 |
0.433
|
|
|
|
regulation of rac protein signal transduction
|
GO:0035020 |
19 |
0.432
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
18 |
0.430
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
114 |
0.429
|
|
|
|
organelle localization
|
GO:0051640 |
179 |
0.429
|
|
|
|
axon guidance
|
GO:0007411 |
141 |
0.424
|
|
|
|
gland development
|
GO:0048732 |
330 |
0.423
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
233 |
0.421
|
|
|
|
embryonic placenta development
|
GO:0001892 |
98 |
0.419
|
|
|
|
locomotory behavior
|
GO:0007626 |
195 |
0.417
|
|
|
|
b cell activation
|
GO:0042113 |
161 |
0.415
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
174 |
0.414
|
|
|
|
chemotaxis
|
GO:0006935 |
247 |
0.412
|
|
|
|
synapse organization
|
GO:0050808 |
125 |
0.409
|
|
|
|
regulation of synaptic growth at neuromuscular junction
|
GO:0008582 |
4 |
0.408
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
109 |
0.406
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
115 |
0.405
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
49 |
0.404
|
|
|
|
translation
|
GO:0006412 |
93 |
0.401
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
121 |
0.400
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
167 |
0.399
|
|
|
|
regulation of regulated secretory pathway
|
GO:1903305 |
20 |
0.395
|
|
|
|
leukocyte degranulation
|
GO:0043299 |
27 |
0.390
|
|
|
|
regulation of cell shape
|
GO:0008360 |
39 |
0.390
|
Fly |
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
121 |
0.389
|
|
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
41 |
0.388
|
|
|
|
glutamate receptor signaling pathway
|
GO:0007215 |
35 |
0.385
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
154 |
0.385
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
65 |
0.378
|
|
|
|
regulation of translation
|
GO:0006417 |
71 |
0.377
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
119 |
0.375
|
|
|
|
regulation of actin cytoskeleton reorganization
|
GO:2000249 |
9 |
0.373
|
|
|
|
protein localization to organelle
|
GO:0033365 |
185 |
0.369
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
92 |
0.366
|
Human |
|
|
associative learning
|
GO:0008306 |
61 |
0.364
|
Fly |
|
|
osteoclast differentiation
|
GO:0030316 |
62 |
0.359
|
|
|
|
negative regulation of toll like receptor signaling pathway
|
GO:0034122 |
14 |
0.357
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
31 |
0.357
|
|
|
|
regulation of t cell differentiation in thymus
|
GO:0033081 |
24 |
0.355
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
114 |
0.355
|
|
|
|
positive regulation of mast cell activation
|
GO:0033005 |
12 |
0.350
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
208 |
0.349
|
|
|
|
cation transport
|
GO:0006812 |
399 |
0.349
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
46 |
0.347
|
|
|
|
regulation of organ formation
|
GO:0003156 |
34 |
0.345
|
|
|
|
regulation of leukocyte degranulation
|
GO:0043300 |
20 |
0.344
|
|
|
|
toll like receptor signaling pathway
|
GO:0002224 |
38 |
0.342
|
|
|
|
purine nucleoside metabolic process
|
GO:0042278 |
241 |
0.342
|
|
|
|
axonogenesis
|
GO:0007409 |
274 |
0.339
|
|
|
|
phagocytosis
|
GO:0006909 |
66 |
0.337
|
|
|
|
aromatic compound catabolic process
|
GO:0019439 |
286 |
0.336
|
|
|
|
cellular nitrogen compound catabolic process
|
GO:0044270 |
280 |
0.336
|
|
|
|
prostate gland epithelium morphogenesis
|
GO:0060740 |
31 |
0.333
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
206 |
0.332
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
56 |
0.331
|
|
|
|
regulated secretory pathway
|
GO:0045055 |
32 |
0.331
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
71 |
0.331
|
|
|
|
regulation of toll like receptor signaling pathway
|
GO:0034121 |
20 |
0.327
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
119 |
0.326
|
|
|
|
regulation of bone resorption
|
GO:0045124 |
24 |
0.325
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
249 |
0.324
|
|
|
|
macromolecule catabolic process
|
GO:0009057 |
281 |
0.318
|
|
|
|
germ cell development
|
GO:0007281 |
185 |
0.316
|
|
|
|
synaptic transmission glutamatergic
|
GO:0035249 |
36 |
0.315
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
181 |
0.313
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
217 |
0.310
|
|
|
|
regulation of synaptic vesicle transport
|
GO:1902803 |
13 |
0.309
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
221 |
0.305
|
Fly |
|
|
synaptic transmission
|
GO:0007268 |
329 |
0.305
|
|
|
|
female sex differentiation
|
GO:0046660 |
84 |
0.304
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
91 |
0.303
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
86 |
0.301
|
|
|
|
regulation of podosome assembly
|
GO:0071801 |
3 |
0.300
|
|
|
|
organ regeneration
|
GO:0031100 |
2 |
0.300
|
|
|
|
humoral immune response
|
GO:0006959 |
57 |
0.297
|
|
|
|
tor signaling
|
GO:0031929 |
21 |
0.295
|
Fly |
|
|
prostate glandular acinus morphogenesis
|
GO:0060526 |
7 |
0.294
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
108 |
0.294
|
|
|
|
regulation of t cell receptor signaling pathway
|
GO:0050856 |
21 |
0.293
|
|
|
|
negative regulation of antigen receptor mediated signaling pathway
|
GO:0050858 |
16 |
0.291
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
114 |
0.290
|
|
|
|
b cell proliferation
|
GO:0042100 |
53 |
0.290
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
38 |
0.290
|
|
|
|
endothelial cell migration
|
GO:0043542 |
44 |
0.289
|
|
|
|
purine containing compound metabolic process
|
GO:0072521 |
311 |
0.288
|
|
|
|
leukocyte homeostasis
|
GO:0001776 |
79 |
0.288
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
48 |
0.285
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
126 |
0.284
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.281
|
|
|
|
regulation of epidermal growth factor receptor signaling pathway
|
GO:0042058 |
13 |
0.281
|
Fly |
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
1 |
0.281
|
|
|
|
positive regulation of mitotic cell cycle phase transition
|
GO:1901992 |
17 |
0.280
|
|
|
|
tissue remodeling
|
GO:0048771 |
102 |
0.277
|
|
|
|
spermatogenesis
|
GO:0007283 |
284 |
0.276
|
|
|
|
negative regulation of cellular response to insulin stimulus
|
GO:1900077 |
16 |
0.276
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
79 |
0.275
|
|
|
|
multicellular organismal reproductive behavior
|
GO:0033057 |
23 |
0.275
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
189 |
0.272
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
107 |
0.271
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
130 |
0.270
|
|
|
|
cell killing
|
GO:0001906 |
67 |
0.268
|
|
|
|
cell cell junction organization
|
GO:0045216 |
72 |
0.267
|
|
|
|
nucleoside phosphate metabolic process
|
GO:0006753 |
338 |
0.266
|
|
|
|
regulation of pro b cell differentiation
|
GO:2000973 |
5 |
0.266
|
|
|
|
glycosyl compound metabolic process
|
GO:1901657 |
246 |
0.266
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
30 |
0.262
|
|
|
|
inflammatory response
|
GO:0006954 |
244 |
0.260
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
20 |
0.260
|
|
|
|
actin filament polymerization
|
GO:0030041 |
44 |
0.258
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
192 |
0.254
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
40 |
0.253
|
|
|
|
regulation of protein autophosphorylation
|
GO:0031952 |
8 |
0.253
|
|
|
|
negative regulation of molecular function
|
GO:0044092 |
258 |
0.252
|
Fly |
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
12 |
0.251
|
|
|
|
establishment of synaptic vesicle localization
|
GO:0097480 |
57 |
0.250
|
|
|
|
jnk cascade
|
GO:0007254 |
72 |
0.249
|
|
|
|
peptidyl amino acid modification
|
GO:0018193 |
336 |
0.248
|
Fly |
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
25 |
0.248
|
|
|
|
actin filament organization
|
GO:0007015 |
113 |
0.245
|
|
|
|
regulation of neuron projection development
|
GO:0010975 |
169 |
0.245
|
|
|
|
branching involved in prostate gland morphogenesis
|
GO:0060442 |
15 |
0.243
|
|
|
|
gamma delta t cell differentiation
|
GO:0042492 |
11 |
0.243
|
|
|
|
regulation of keratinocyte differentiation
|
GO:0045616 |
11 |
0.241
|
|
|
|
regulation of secretion
|
GO:0051046 |
274 |
0.237
|
|
|
|
platelet aggregation
|
GO:0070527 |
20 |
0.236
|
|
|
|
bone resorption
|
GO:0045453 |
38 |
0.235
|
|
|
|
positive regulation of t cell differentiation
|
GO:0045582 |
52 |
0.235
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
70 |
0.234
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
241 |
0.233
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
45 |
0.233
|
|
|
|
cytokine production
|
GO:0001816 |
319 |
0.233
|
|
|
|
learning or memory
|
GO:0007611 |
148 |
0.232
|
Fly |
|
|
regulation of gamma delta t cell differentiation
|
GO:0045586 |
9 |
0.230
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
52 |
0.230
|
Fly |
|
|
cellular homeostasis
|
GO:0019725 |
240 |
0.225
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
151 |
0.224
|
|
|
|
specification of organ identity
|
GO:0010092 |
30 |
0.223
|
|
|
|
extracellular matrix dependent thymocyte migration
|
GO:0072680 |
1 |
0.223
|
|
|
|
regulation of calcium mediated signaling
|
GO:0050848 |
19 |
0.223
|
|
|
|
intracellular distribution of mitochondria
|
GO:0048312 |
1 |
0.221
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
205 |
0.221
|
|
|
|
negative regulation of lymphocyte activation
|
GO:0051250 |
91 |
0.219
|
|
|
|
intracellular protein transport
|
GO:0006886 |
204 |
0.218
|
|
|
|
gastrulation
|
GO:0007369 |
116 |
0.216
|
|
|
|
cell recognition
|
GO:0008037 |
83 |
0.215
|
|
|
|
mitotic cytokinesis
|
GO:0000281 |
4 |
0.215
|
|
|
|
positive regulation of gamma delta t cell differentiation
|
GO:0045588 |
6 |
0.215
|
|
|
|
phosphatidylinositol biosynthetic process
|
GO:0006661 |
15 |
0.214
|
|
|
|
adherens junction maintenance
|
GO:0034334 |
1 |
0.214
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
104 |
0.212
|
|
|
|
response to peptide
|
GO:1901652 |
136 |
0.212
|
Human |
|
|
camera type eye development
|
GO:0043010 |
266 |
0.209
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
19 |
0.209
|
|
|
|
positive regulation of b cell receptor signaling pathway
|
GO:0050861 |
4 |
0.208
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
57 |
0.208
|
|
|
|
positive regulation of lymphocyte differentiation
|
GO:0045621 |
61 |
0.207
|
|
|
|
regulation of b cell proliferation
|
GO:0030888 |
39 |
0.206
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
69 |
0.205
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
91 |
0.205
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
23 |
0.203
|
|
|
|
cation homeostasis
|
GO:0055080 |
212 |
0.202
|
|
|
|
protein catabolic process
|
GO:0030163 |
221 |
0.201
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
54 |
0.197
|
|
|
|
male gamete generation
|
GO:0048232 |
285 |
0.196
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
126 |
0.195
|
|
|
|
conditioned taste aversion
|
GO:0001661 |
4 |
0.193
|
|
|
|
regulation of epidermal cell differentiation
|
GO:0045604 |
21 |
0.193
|
|
|
|
macrophage differentiation
|
GO:0030225 |
20 |
0.191
|
|
|
|
positive regulation of lymphocyte anergy
|
GO:0002913 |
4 |
0.191
|
|
|
|
trivalent inorganic cation transport
|
GO:0072512 |
5 |
0.190
|
|
|
|
regulation of system process
|
GO:0044057 |
200 |
0.190
|
|
|
|
ventricular septum development
|
GO:0003281 |
42 |
0.190
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
3 |
0.189
|
|
|
|
regulation of cell migration
|
GO:0030334 |
219 |
0.189
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
138 |
0.187
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
143 |
0.187
|
|
|
|
mitochondrion organization
|
GO:0007005 |
134 |
0.187
|
|
|
|
forebrain development
|
GO:0030900 |
302 |
0.186
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
73 |
0.186
|
|
|
|
cell junction organization
|
GO:0034330 |
77 |
0.186
|
|
|
|
negative regulation of t cell proliferation
|
GO:0042130 |
38 |
0.185
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
226 |
0.184
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
46 |
0.180
|
|
|
|
cell chemotaxis
|
GO:0060326 |
81 |
0.179
|
|
|
|
positive regulation of podosome assembly
|
GO:0071803 |
3 |
0.179
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
178 |
0.176
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
80 |
0.175
|
|
|
|
behavioral response to nutrient
|
GO:0051780 |
1 |
0.174
|
|
|
|
humoral immune response mediated by circulating immunoglobulin
|
GO:0002455 |
14 |
0.174
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
77 |
0.173
|
|
|
|
male sex differentiation
|
GO:0046661 |
109 |
0.173
|
Worm |
|
|
cell fate commitment
|
GO:0045165 |
210 |
0.173
|
Fly |
|
|
renal system development
|
GO:0072001 |
225 |
0.172
|
|
|
|
prostate glandular acinus development
|
GO:0060525 |
12 |
0.170
|
|
|
|
secondary metabolic process
|
GO:0019748 |
18 |
0.169
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
95 |
0.164
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
112 |
0.164
|
|
|
|
negative regulation of canonical wnt signaling pathway
|
GO:0090090 |
51 |
0.162
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
83 |
0.162
|
|
|
|
negative regulation of leukocyte mediated immunity
|
GO:0002704 |
29 |
0.161
|
|
|
|
regulation of t cell mediated cytotoxicity
|
GO:0001914 |
18 |
0.161
|
|
|
|
substrate adhesion dependent cell spreading
|
GO:0034446 |
30 |
0.161
|
|
|
|
mitochondrion distribution
|
GO:0048311 |
4 |
0.160
|
|
|
|
negative regulation of neural precursor cell proliferation
|
GO:2000178 |
18 |
0.159
|
|
|
|
rap protein signal transduction
|
GO:0032486 |
3 |
0.157
|
|
|
|
neutrophil differentiation
|
GO:0030223 |
3 |
0.157
|
|
|
|
muscle cell proliferation
|
GO:0033002 |
52 |
0.156
|
|
|
|
regulation of mast cell proliferation
|
GO:0070666 |
4 |
0.154
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.153
|
Fly |
|
|
blood vessel morphogenesis
|
GO:0048514 |
285 |
0.152
|
|
|
|
neuron recognition
|
GO:0008038 |
25 |
0.152
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
22 |
0.149
|
|
|
|
organ induction
|
GO:0001759 |
21 |
0.148
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
157 |
0.147
|
|
