Mus musculus

36 known processes

Gzmb

granzyme B

(Aliases: Ctla-1,AI553453,Ctla1,GZB,CCP-1/C11,CCP1)

Gzmb biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.986
defense response to other organism GO:0098542 197 0.974
Mouse
regulation of innate immune response GO:0045088 91 0.953
cytokine mediated signaling pathway GO:0019221 115 0.950
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.856
defense response to gram positive bacterium GO:0050830 50 0.842
Mouse
response to molecule of bacterial origin GO:0002237 143 0.833
Mouse
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.825
regulation of defense response GO:0031347 233 0.816
response to lipopolysaccharide GO:0032496 128 0.816
Mouse
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.787
leukocyte mediated cytotoxicity GO:0001909 62 0.783
immune effector process GO:0002252 321 0.774
positive regulation of defense response GO:0031349 124 0.762
cytokine production GO:0001816 319 0.738
positive regulation of t cell costimulation GO:2000525 2 0.707
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.703
adaptive immune response GO:0002250 155 0.687
defense response to bacterium GO:0042742 119 0.683
Mouse
natural killer cell activation GO:0030101 44 0.682
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.672
regulation of angiotensin metabolic process GO:0060177 4 0.671
Mouse
interleukin 12 secretion GO:0072610 3 0.670
mature dendritic cell differentiation GO:0097029 3 0.653
regulation of cytokine production GO:0001817 266 0.651
cell killing GO:0001906 67 0.649
cellular response to lipopolysaccharide GO:0071222 77 0.637
detection of fungus GO:0016046 2 0.633
regulation of angiotensin levels in blood GO:0002002 4 0.632
Mouse
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.603
Mouse
myeloid leukocyte differentiation GO:0002573 119 0.597
killing by host of symbiont cells GO:0051873 11 0.577
Mouse
positive regulation of cytokine production GO:0001819 174 0.572
response to molecule of fungal origin GO:0002238 4 0.571
regulation of leukocyte mediated immunity GO:0002703 104 0.559
leukocyte mediated immunity GO:0002443 174 0.543
regulation of natural killer cell mediated immunity GO:0002715 19 0.531
myeloid cell differentiation GO:0030099 233 0.516
positive regulation of monocyte chemotaxis GO:0090026 2 0.512
t cell mediated cytotoxicity GO:0001913 26 0.512
pattern recognition receptor signaling pathway GO:0002221 47 0.498
regulation of establishment of protein localization GO:0070201 181 0.494
positive regulation of innate immune response GO:0045089 80 0.484
immune response activating signal transduction GO:0002757 116 0.482
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.479
innate immune response GO:0045087 157 0.472
regulation of monocyte chemotaxis GO:0090025 3 0.458
cytokine secretion GO:0050663 72 0.452
cellular response to molecule of fungal origin GO:0071226 2 0.451
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.448
interspecies interaction between organisms GO:0044419 83 0.438
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.437
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.434
positive regulation of t cell activation GO:0050870 101 0.432
microglial cell activation involved in immune response GO:0002282 1 0.430
negative regulation of immune system process GO:0002683 209 0.429
positive regulation of cell killing GO:0031343 33 0.428
leukocyte chemotaxis GO:0030595 69 0.405
interferon gamma production GO:0032609 67 0.405
leukocyte activation involved in immune response GO:0002366 126 0.404
natural killer cell mediated immunity GO:0002228 29 0.391
cellular response to cytokine stimulus GO:0071345 189 0.383
regulation of interferon gamma production GO:0032649 57 0.379
disruption by host of symbiont cells GO:0051852 11 0.379
Mouse
immune response regulating signaling pathway GO:0002764 125 0.369
eosinophil activation involved in immune response GO:0002278 1 0.356
regulation of cell killing GO:0031341 40 0.346
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.342
positive regulation of interferon gamma production GO:0032729 39 0.341
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.339
Mouse
regulation of alpha beta t cell proliferation GO:0046640 18 0.336
neutrophil mediated cytotoxicity GO:0070942 8 0.330
Mouse
lymphocyte mediated immunity GO:0002449 139 0.327
activation of innate immune response GO:0002218 56 0.324
regulation of membrane potential GO:0042391 192 0.320
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.318
natural killer cell mediated cytotoxicity GO:0042267 29 0.314
lymphocyte costimulation GO:0031294 15 0.305
myeloid leukocyte mediated immunity GO:0002444 42 0.304
Mouse
regulation of lymphocyte mediated immunity GO:0002706 84 0.298
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.297
defense response to virus GO:0051607 68 0.295
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.294
positive regulation of leukocyte mediated immunity GO:0002705 70 0.293
cellular response to lipid GO:0071396 145 0.290
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.290
activation of immune response GO:0002253 138 0.289
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.289
Mouse
cellular response to biotic stimulus GO:0071216 92 0.288
modulation of growth of symbiont involved in interaction with host GO:0044144 19 0.282
Mouse
leukocyte differentiation GO:0002521 342 0.281
regulation of protein localization GO:0032880 231 0.277
regulation of cell activation GO:0050865 289 0.263
alpha beta t cell activation GO:0046631 91 0.261
regulation of lymphocyte activation GO:0051249 240 0.260
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.260
Mouse
regulation of ion homeostasis GO:2000021 64 0.258
cell type specific apoptotic process GO:0097285 268 0.257
regulation of alpha beta t cell activation GO:0046634 53 0.256
regulation of cytokine secretion GO:0050707 61 0.256
apoptotic signaling pathway GO:0097190 306 0.249
t helper 1 cell cytokine production GO:0035744 1 0.249
negative regulation of macrophage apoptotic process GO:2000110 3 0.246
cell chemotaxis GO:0060326 81 0.245
cell activation involved in immune response GO:0002263 126 0.239
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.237
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.234
regulation of cell migration GO:0030334 219 0.233
cell adhesion GO:0007155 329 0.232
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.220
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.218
cellular nitrogen compound catabolic process GO:0044270 280 0.216
detection of yeast GO:0001879 2 0.216
positive regulation of immune effector process GO:0002699 107 0.211
regulation of tumor necrosis factor production GO:0032680 49 0.207
heterocycle catabolic process GO:0046700 280 0.206
regulation of protein secretion GO:0050708 82 0.203
regulation of secretion by cell GO:1903530 249 0.201
natural killer cell inhibitory signaling pathway GO:0002769 2 0.199
natural killer cell chemotaxis GO:0035747 1 0.199
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.199
interleukin 1 beta secretion GO:0050702 16 0.198
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.195
detection of other organism GO:0098543 8 0.193
negative regulation of growth of symbiont in host GO:0044130 19 0.192
Mouse
positive regulation of chemotaxis GO:0050921 38 0.192
t cell activation GO:0042110 289 0.191
positive regulation of granulocyte chemotaxis GO:0071624 12 0.190
negative regulation of eosinophil degranulation GO:0043310 1 0.187
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.187
cellular response to molecule of bacterial origin GO:0071219 83 0.184
killing of cells of other organism GO:0031640 13 0.183
Mouse
regulation of cd8 positive alpha beta t cell extravasation GO:2000449 3 0.181
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.181
regulation of multi organism process GO:0043900 111 0.181
Mouse
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.180
regulation of interleukin 10 secretion GO:2001179 4 0.180
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.179
t cell costimulation GO:0031295 14 0.179
growth of symbiont in host GO:0044117 23 0.178
Mouse
cdc42 protein signal transduction GO:0032488 0 0.178
eosinophil activation GO:0043307 1 0.177
regulation of protein transport GO:0051223 163 0.177
growth of symbiont involved in interaction with host GO:0044116 23 0.176
Mouse
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.175
tumor necrosis factor production GO:0032640 50 0.174
dendritic cell chemotaxis GO:0002407 7 0.174
extrinsic apoptotic signaling pathway GO:0097191 126 0.173
positive regulation of lymphocyte proliferation GO:0050671 70 0.173
interleukin 1 production GO:0032612 31 0.172
leukocyte proliferation GO:0070661 172 0.172
positive regulation of neutrophil chemotaxis GO:0090023 12 0.172
positive regulation of leukocyte differentiation GO:1902107 86 0.169
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.169
regulation of adaptive immune response GO:0002819 90 0.169
sequestering of calcium ion GO:0051208 18 0.168
protein secretion GO:0009306 111 0.165
interleukin 10 secretion GO:0072608 4 0.164
positive regulation of t cell proliferation GO:0042102 52 0.164
production of molecular mediator of immune response GO:0002440 103 0.164
divalent inorganic cation homeostasis GO:0072507 138 0.163
organic cyclic compound catabolic process GO:1901361 295 0.160
interaction with symbiont GO:0051702 14 0.159
Mouse
positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation GO:2000526 1 0.157
cation transport GO:0006812 399 0.157
t cell mediated immunity GO:0002456 50 0.155
regulation of dendritic cell dendrite assembly GO:2000547 2 0.154
myeloid leukocyte migration GO:0097529 57 0.152
neutrophil mediated killing of symbiont cell GO:0070943 8 0.152
Mouse
negative t cell selection GO:0043383 13 0.151
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.147
cellular amine metabolic process GO:0044106 44 0.146
innate immune response activating signal transduction GO:0002758 50 0.145
positive regulation of immunological synapse formation GO:2000522 1 0.144
membrane organization GO:0061024 245 0.143
negative regulation of growth GO:0045926 99 0.142
Mouse
regulation of type 2 immune response GO:0002828 18 0.141
helper t cell chemotaxis GO:0035704 1 0.139
myeloid leukocyte activation GO:0002274 83 0.138
reactive nitrogen species metabolic process GO:2001057 0 0.136
regulation of skeletal muscle fiber development GO:0048742 36 0.135
regulation of t cell proliferation GO:0042129 92 0.134
carbohydrate derivative biosynthetic process GO:1901137 183 0.134
regulation of t cell extravasation GO:2000407 3 0.134
regulation of dendritic cell chemotaxis GO:2000508 1 0.133
response to interferon gamma GO:0034341 34 0.133
chemokine mediated signaling pathway GO:0070098 17 0.133
angiogenesis GO:0001525 201 0.133
neutrophil mediated immunity GO:0002446 19 0.132
Mouse
regulation of leukocyte apoptotic process GO:2000106 56 0.132
t helper 1 type immune response GO:0042088 25 0.130
positive regulation of interleukin 12 production GO:0032735 21 0.129
neutrophil migration GO:1990266 37 0.128
neutrophil mediated killing of bacterium GO:0070944 6 0.127
Mouse
leukocyte migration GO:0050900 124 0.126
granulocyte chemotaxis GO:0071621 39 0.125
astrocyte cell migration GO:0043615 3 0.125
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.125
metal ion homeostasis GO:0055065 189 0.125
regulation of leukocyte differentiation GO:1902105 159 0.124
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.124
regulation of vesicle mediated transport GO:0060627 139 0.123
cellular response to interleukin 15 GO:0071350 2 0.123
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.123
dendritic cell dendrite assembly GO:0097026 2 0.122
negative regulation of secretion GO:0051048 61 0.122
regulation of natural killer cell chemotaxis GO:2000501 1 0.122
eosinophil degranulation GO:0043308 1 0.122
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.121
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.120
Mouse
cellular divalent inorganic cation homeostasis GO:0072503 127 0.120
positive regulation of behavior GO:0048520 40 0.118
negative regulation of innate immune response GO:0045824 17 0.117
leukocyte apoptotic process GO:0071887 71 0.116
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.115
regulation of growth of symbiont in host GO:0044126 19 0.115
Mouse
eosinophil mediated immunity GO:0002447 1 0.115
interleukin 1 secretion GO:0050701 16 0.114
positive regulation of cytokine secretion GO:0050715 41 0.112
regulation of hormone levels GO:0010817 211 0.111
Mouse
blood vessel morphogenesis GO:0048514 285 0.111
dendritic cell antigen processing and presentation GO:0002468 7 0.110
positive regulation of type 2 immune response GO:0002830 9 0.110
nucleobase containing small molecule metabolic process GO:0055086 352 0.109
mature natural killer cell chemotaxis GO:0035782 1 0.109
antigen receptor mediated signaling pathway GO:0050851 64 0.108
sequestering of metal ion GO:0051238 19 0.108
positive regulation of cellular amine metabolic process GO:0033240 5 0.106
t cell extravasation GO:0072683 4 0.106
reactive oxygen species metabolic process GO:0072593 84 0.106
positive regulation of t cell extravasation GO:2000409 2 0.106
positive regulation of alpha beta t cell activation GO:0046635 39 0.105
regulation of eosinophil degranulation GO:0043309 1 0.104
negative thymic t cell selection GO:0045060 12 0.104
second messenger mediated signaling GO:0019932 73 0.104
purine containing compound metabolic process GO:0072521 311 0.104
cytokine production involved in immune response GO:0002367 34 0.104
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.103
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.102
regulation of lymphocyte proliferation GO:0050670 117 0.102
positive regulation of thymocyte migration GO:2000412 2 0.102
peptidyl tyrosine modification GO:0018212 145 0.101
dendritic cell differentiation GO:0097028 26 0.101
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.100
regulation of cellular amine metabolic process GO:0033238 20 0.100
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.098
regulation of cell motility GO:2000145 236 0.098
regulation of monocyte extravasation GO:2000437 2 0.096
t cell migration GO:0072678 19 0.096
regulation of myoblast differentiation GO:0045661 29 0.096
negative regulation of cell activation GO:0050866 111 0.095
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.095
positive regulation of t cell receptor signaling pathway GO:0050862 4 0.095
regulation of t cell activation GO:0050863 170 0.094
purine nucleotide metabolic process GO:0006163 302 0.094
negative regulation of multi organism process GO:0043901 68 0.094
Mouse
regulation of regulated secretory pathway GO:1903305 20 0.093
cation homeostasis GO:0055080 212 0.093
negative regulation of defense response GO:0031348 77 0.093
t cell differentiation GO:0030217 174 0.092
regulation of cellular ketone metabolic process GO:0010565 66 0.091
alpha beta t cell proliferation GO:0046633 21 0.090
single organismal cell cell adhesion GO:0016337 131 0.090
macromolecule catabolic process GO:0009057 281 0.089
regulation of hydrolase activity GO:0051336 246 0.088
regulation of interleukin 1 beta secretion GO:0050706 15 0.088
signal transduction in absence of ligand GO:0038034 55 0.088
lymphocyte proliferation GO:0046651 164 0.088
t cell activation involved in immune response GO:0002286 43 0.087
positive regulation of alpha beta t cell proliferation GO:0046641 12 0.087
aromatic compound catabolic process GO:0019439 286 0.087
organ or tissue specific immune response GO:0002251 13 0.085
regulation of neutrophil chemotaxis GO:0090022 14 0.085
nucleotide metabolic process GO:0009117 332 0.084
type 2 immune response GO:0042092 23 0.084
regulation of b cell chemotaxis GO:2000537 2 0.082
microglial cell activation GO:0001774 3 0.082
regulation of t helper 2 cell cytokine production GO:2000551 3 0.081
dendritic cell migration GO:0036336 12 0.080
cellular macromolecule catabolic process GO:0044265 206 0.079
positive regulation of cell migration GO:0030335 109 0.079
immune complex clearance by monocytes and macrophages GO:0002436 2 0.079
reactive oxygen species biosynthetic process GO:1903409 8 0.078
positive regulation of monocyte extravasation GO:2000439 1 0.078
calcium ion homeostasis GO:0055074 127 0.077
positive regulation of lymphocyte migration GO:2000403 11 0.077
regulation of interleukin 12 production GO:0032655 30 0.076
regulation of cytokine biosynthetic process GO:0042035 59 0.076
nucleoside phosphate metabolic process GO:0006753 338 0.076
negative regulation of phosphorus metabolic process GO:0010563 184 0.076
monocyte extravasation GO:0035696 2 0.076
negative regulation of leukocyte apoptotic process GO:2000107 31 0.076
regulation of eosinophil migration GO:2000416 2 0.075
rho protein signal transduction GO:0007266 32 0.075
positive regulation of dendritic cell chemotaxis GO:2000510 1 0.075
lymphocyte activation involved in immune response GO:0002285 93 0.074
hematopoietic stem cell migration GO:0035701 1 0.074
regulation of chemotaxis GO:0050920 53 0.074
inflammatory response GO:0006954 244 0.074
small gtpase mediated signal transduction GO:0007264 97 0.074
chemotaxis GO:0006935 247 0.073
t cell selection GO:0045058 34 0.073
positive regulation of lymphocyte activation GO:0051251 140 0.072
t cell proliferation GO:0042098 120 0.072
positive regulation of tumor necrosis factor production GO:0032760 30 0.072
cellular amino acid metabolic process GO:0006520 103 0.072
cellular extravasation GO:0045123 17 0.071
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.070
positive regulation of inflammatory response GO:0050729 47 0.070
purine nucleoside triphosphate catabolic process GO:0009146 203 0.070
glycoprotein biosynthetic process GO:0009101 89 0.069
cytokine biosynthetic process GO:0042089 68 0.068
t helper 17 cell chemotaxis GO:0035705 1 0.068
regulation of systemic arterial blood pressure GO:0003073 61 0.067
Mouse
macrophage apoptotic process GO:0071888 7 0.066
antigen processing and presentation GO:0019882 47 0.066
t cell differentiation involved in immune response GO:0002292 30 0.065
ribonucleotide metabolic process GO:0009259 291 0.065
peptidyl amino acid modification GO:0018193 336 0.065
divalent metal ion transport GO:0070838 172 0.065
interleukin 2 production GO:0032623 33 0.064
regulation of interleukin 1 secretion GO:0050704 15 0.064
negative regulation of myoblast differentiation GO:0045662 18 0.064
lymphocyte migration GO:0072676 26 0.063
calcium ion transport GO:0006816 159 0.063
inflammatory cell apoptotic process GO:0006925 11 0.063
positive regulation of b cell chemotaxis GO:2000538 2 0.063
cytosolic calcium ion homeostasis GO:0051480 70 0.063
regulation of secretion GO:0051046 274 0.063
disruption of cells of other organism GO:0044364 13 0.063
Mouse
regulation of t cell costimulation GO:2000523 2 0.062
negative regulation of cytokine production GO:0001818 84 0.062
monocarboxylic acid transport GO:0015718 44 0.061
multicellular organismal homeostasis GO:0048871 164 0.061
striated muscle cell development GO:0055002 125 0.060
myeloid cell apoptotic process GO:0033028 22 0.059
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 13 0.059
Mouse
regulation of neutrophil migration GO:1902622 14 0.059
eosinophil migration GO:0072677 3 0.059
morphogenesis of a branching structure GO:0001763 203 0.059
negative regulation of myeloid cell apoptotic process GO:0033033 11 0.058
epithelial tube morphogenesis GO:0060562 303 0.058
positive regulation of leukocyte proliferation GO:0070665 73 0.058
immunoglobulin production in mucosal tissue GO:0002426 3 0.057
b cell mediated immunity GO:0019724 71 0.057
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.057
regulation of interleukin 2 production GO:0032663 28 0.057
negative regulation of angiogenesis GO:0016525 25 0.057
amine metabolic process GO:0009308 45 0.057
myotube differentiation GO:0014902 105 0.057
peptidyl tyrosine phosphorylation GO:0018108 143 0.057
regulation of reactive oxygen species metabolic process GO:2000377 40 0.057
osteoclast differentiation GO:0030316 62 0.056
regulation of myotube differentiation GO:0010830 62 0.056
neutrophil chemotaxis GO:0030593 36 0.056
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.056
interleukin 1 beta production GO:0032611 30 0.056
cellular response to drug GO:0035690 15 0.055
cytosolic calcium ion transport GO:0060401 48 0.055
positive regulation of immune complex clearance by monocytes and macrophages GO:0090265 2 0.054
granulocyte migration GO:0097530 43 0.054
positive regulation of response to wounding GO:1903036 66 0.054
positive regulation of cell death GO:0010942 224 0.054
Rat
positive regulation of endocytosis GO:0045807 42 0.053
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.053
carbohydrate derivative catabolic process GO:1901136 231 0.053
i kappab kinase nf kappab signaling GO:0007249 85 0.053
sensory perception GO:0007600 245 0.053
endocytosis GO:0006897 168 0.053
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.053
single organism cell adhesion GO:0098602 156 0.052
anion transport GO:0006820 177 0.051
positive regulation of ion transport GO:0043270 65 0.051
cytoplasmic transport GO:0016482 234 0.051
b cell chemotaxis GO:0035754 3 0.050
t cell receptor signaling pathway GO:0050852 46 0.050
thymic t cell selection GO:0045061 22 0.050
interleukin 12 production GO:0032615 32 0.050
growth involved in symbiotic interaction GO:0044110 23 0.050
Mouse
ribonucleoside catabolic process GO:0042454 206 0.050
positive regulation of secretion GO:0051047 130 0.050
regulation of homeostatic process GO:0032844 182 0.049
phagocytosis GO:0006909 66 0.049
positive regulation of apoptotic process GO:0043065 217 0.049
negative regulation of signal transduction in absence of ligand GO:1901099 16 0.049
blood circulation GO:0008015 195 0.049
Mouse
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.049
regulation of antigen processing and presentation GO:0002577 10 0.049
cellular lipid metabolic process GO:0044255 323 0.048
lymphocyte homeostasis GO:0002260 64 0.048
organelle assembly GO:0070925 177 0.048
stress activated protein kinase signaling cascade GO:0031098 81 0.048
regulation of natural killer cell activation GO:0032814 22 0.047
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.047
regulation of leukocyte proliferation GO:0070663 121 0.047
organophosphate catabolic process GO:0046434 232 0.047
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.047
Mouse
engulfment of apoptotic cell GO:0043652 3 0.046
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.046
negative regulation of leukocyte mediated immunity GO:0002704 29 0.046
negative regulation of interleukin 10 secretion GO:2001180 2 0.046
branching morphogenesis of an epithelial tube GO:0048754 159 0.046
regulation of production of molecular mediator of immune response GO:0002700 65 0.045
lymph node development GO:0048535 18 0.045
regulation of phagocytosis GO:0050764 33 0.045
regulation of angiogenesis GO:0045765 81 0.045
regulation of response to wounding GO:1903034 189 0.045
t helper 2 cell cytokine production GO:0035745 4 0.045
leukocyte degranulation GO:0043299 27 0.044
t helper cell differentiation GO:0042093 28 0.044
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.044
positive regulation of neuron apoptotic process GO:0043525 25 0.044
positive regulation of cell development GO:0010720 237 0.044
response to organic cyclic compound GO:0014070 198 0.044
regulation of immunoglobulin production GO:0002637 42 0.043
positive regulation of cell motility GO:2000147 116 0.043
positive regulation of neutrophil migration GO:1902624 12 0.043
glycoprotein metabolic process GO:0009100 116 0.043
mast cell proliferation GO:0070662 4 0.043
purinergic nucleotide receptor signaling pathway GO:0035590 3 0.043
positive regulation of hydrolase activity GO:0051345 148 0.043
modification of morphology or physiology of other organism GO:0035821 18 0.043
Mouse
thymocyte migration GO:0072679 2 0.043
regulation of cellular amino acid metabolic process GO:0006521 5 0.043
protein catabolic process GO:0030163 221 0.042
positive regulation of neuron death GO:1901216 28 0.042
toll like receptor signaling pathway GO:0002224 38 0.042
regulation of cellular component biogenesis GO:0044087 181 0.042
regulation of t helper 1 cell cytokine production GO:2000554 1 0.042
dna recombination GO:0006310 92 0.042
regulation of t helper 1 type immune response GO:0002825 17 0.042
regulation of cellular catabolic process GO:0031329 242 0.042
oligodendrocyte differentiation GO:0048709 53 0.042
receptor mediated endocytosis GO:0006898 51 0.042
cellular response to dna damage stimulus GO:0006974 207 0.041
divalent inorganic cation transport GO:0072511 178 0.041
cell recognition GO:0008037 83 0.041
negative regulation of hydrolase activity GO:0051346 71 0.041
negative regulation of protein metabolic process GO:0051248 282 0.041
action potential GO:0001508 78 0.041
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.041
lipopolysaccharide mediated signaling pathway GO:0031663 25 0.041
purine ribonucleoside metabolic process GO:0046128 241 0.041
nucleoside phosphate catabolic process GO:1901292 222 0.040
regulation of intracellular transport GO:0032386 159 0.040
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.040
positive regulation of protein secretion GO:0050714 52 0.039
positive regulation of antigen processing and presentation GO:0002579 10 0.039
cellular ketone metabolic process GO:0042180 84 0.039
positive regulation of t helper 1 type immune response GO:0002827 12 0.039
cellular calcium ion homeostasis GO:0006874 119 0.039
negative regulation of viral transcription GO:0032897 3 0.039
tissue remodeling GO:0048771 102 0.039
regulation of calcium mediated signaling GO:0050848 19 0.038
muscle cell development GO:0055001 133 0.038
neuronal action potential GO:0019228 54 0.038
regulation of cellular response to stress GO:0080135 159 0.038
jnk cascade GO:0007254 72 0.038
skeletal muscle fiber development GO:0048741 58 0.038
nucleoside metabolic process GO:0009116 246 0.037
negative regulation of muscle cell differentiation GO:0051148 33 0.037
calcium ion transport into cytosol GO:0060402 48 0.037
carbohydrate transport GO:0008643 62 0.037
cellular homeostasis GO:0019725 240 0.037
regulation of purine nucleotide metabolic process GO:1900542 169 0.037
purine ribonucleotide metabolic process GO:0009150 290 0.037
morphogenesis of a branching epithelium GO:0061138 193 0.037
t cell chemotaxis GO:0010818 6 0.037
lymphocyte apoptotic process GO:0070227 54 0.036
b cell activation involved in immune response GO:0002312 50 0.036
regulation of apoptotic signaling pathway GO:2001233 197 0.036
regulation of ion transport GO:0043269 215 0.036
myeloid dendritic cell activation GO:0001773 25 0.036
negative regulation of apoptotic signaling pathway GO:2001234 104 0.036
regulation of myeloid cell differentiation GO:0045637 96 0.036
positive regulation of cell projection organization GO:0031346 95 0.036
regulation of vascular endothelial growth factor production GO:0010574 13 0.036
interleukin 2 mediated signaling pathway GO:0038110 2 0.035
response to interleukin 4 GO:0070670 23 0.035
generation of precursor metabolites and energy GO:0006091 103 0.035
muscle fiber development GO:0048747 76 0.035
response to tumor necrosis factor GO:0034612 26 0.035
purine containing compound biosynthetic process GO:0072522 70 0.035
regulation of immunological synapse formation GO:2000520 2 0.035
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.035
regulation of rho protein signal transduction GO:0035023 71 0.035
positive regulation of eosinophil migration GO:2000418 2 0.035
negative regulation of vasculature development GO:1901343 26 0.034
purine nucleoside triphosphate metabolic process GO:0009144 226 0.034
regulation of acute inflammatory response GO:0002673 27 0.034
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.034
Mouse
membrane invagination GO:0010324 17 0.034
negative regulation of phosphate metabolic process GO:0045936 184 0.034
positive regulation of glycoprotein metabolic process GO:1903020 6 0.034
negative regulation of homeostatic process GO:0032845 71 0.034
negative regulation of intracellular signal transduction GO:1902532 167 0.034
response to acid chemical GO:0001101 111 0.033
ribose phosphate metabolic process GO:0019693 291 0.033
lymphocyte differentiation GO:0030098 242 0.033
positive regulation of osteoclast differentiation GO:0045672 15 0.033

Gzmb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org