Mus musculus

0 known processes

Gzme

granzyme E

(Aliases: MCSP-2,Ctla6,CCP3,Ctla-6)

Gzme biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of angiotensin metabolic process GO:0060177 4 0.171
Mouse
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.125
Mouse
regulation of angiotensin levels in blood GO:0002002 4 0.084
Mouse
regulation of microvillus assembly GO:0032534 3 0.083
negative regulation of endothelial cell migration GO:0010596 4 0.077
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.064
regulation of microvillus organization GO:0032530 3 0.059
cellular ketone metabolic process GO:0042180 84 0.053
amine metabolic process GO:0009308 45 0.048
apoptotic signaling pathway GO:0097190 306 0.048
Mouse
response to lipopolysaccharide GO:0032496 128 0.046
Mouse
response to molecule of bacterial origin GO:0002237 143 0.046
Mouse
peptidyl amino acid modification GO:0018193 336 0.044
cell adhesion GO:0007155 329 0.044
regulation of cellular ketone metabolic process GO:0010565 66 0.043
protein catabolic process GO:0030163 221 0.043
sensory perception GO:0007600 245 0.043
adaptive immune response GO:0002250 155 0.041
Mouse
cellular amino acid metabolic process GO:0006520 103 0.039
regulation of cellular amino acid metabolic process GO:0006521 5 0.036
regulation of defense response GO:0031347 233 0.035
regulation of cellular amine metabolic process GO:0033238 20 0.034
regulation of lymphocyte activation GO:0051249 240 0.033
positive regulation of cell development GO:0010720 237 0.033
cellular amine metabolic process GO:0044106 44 0.033
leukocyte mediated immunity GO:0002443 174 0.033
Mouse
lymphocyte mediated immunity GO:0002449 139 0.033
Mouse
blood vessel morphogenesis GO:0048514 285 0.032
male gamete generation GO:0048232 285 0.032
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.031
negative regulation of cellular amine metabolic process GO:0033239 1 0.030
spermatogenesis GO:0007283 284 0.030
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.030
Mouse
immune effector process GO:0002252 321 0.030
Mouse
regulation of transferase activity GO:0051338 263 0.030
killing by host of symbiont cells GO:0051873 11 0.030
Mouse
macromolecule catabolic process GO:0009057 281 0.029
positive regulation of nervous system development GO:0051962 221 0.029
myotube differentiation GO:0014902 105 0.028
positive regulation of protein modification process GO:0031401 299 0.028
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.028
Mouse
striated muscle tissue development GO:0014706 293 0.027
synaptic transmission GO:0007268 329 0.027
cell type specific apoptotic process GO:0097285 268 0.027
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.026
Mouse
positive regulation of cellular amine metabolic process GO:0033240 5 0.026
regulation of cell cycle GO:0051726 281 0.026
skeletal muscle fiber development GO:0048741 58 0.025
regulation of kinase activity GO:0043549 249 0.024
protein modification by small protein conjugation or removal GO:0070647 207 0.024
response to organic cyclic compound GO:0014070 198 0.024
negative regulation of cellular protein metabolic process GO:0032269 247 0.024
negative regulation of growth GO:0045926 99 0.023
Mouse
skeletal muscle organ development GO:0060538 163 0.023
cytokine production GO:0001816 319 0.023
defense response to bacterium GO:0042742 119 0.023
Mouse
leukocyte mediated cytotoxicity GO:0001909 62 0.023
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.023
disruption by host of symbiont cells GO:0051852 11 0.023
Mouse
muscle tissue development GO:0060537 308 0.022
regulation of membrane potential GO:0042391 192 0.022
stem cell proliferation GO:0072089 117 0.022
angiogenesis GO:0001525 201 0.022
small gtpase mediated signal transduction GO:0007264 97 0.022
cellular response to organonitrogen compound GO:0071417 145 0.022
positive regulation of transferase activity GO:0051347 167 0.022
t cell activation GO:0042110 289 0.022
endocrine process GO:0050886 39 0.022
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.021
regulation of myotube differentiation GO:0010830 62 0.021
single organism cell adhesion GO:0098602 156 0.020
leukocyte differentiation GO:0002521 342 0.020
cellular response to hormone stimulus GO:0032870 150 0.020
negative regulation of cell proliferation GO:0008285 296 0.020
carbohydrate metabolic process GO:0005975 230 0.020
negative regulation of protein metabolic process GO:0051248 282 0.020
protein maturation GO:0051604 176 0.020
positive regulation of kinase activity GO:0033674 155 0.020
regulation of cytokine production GO:0001817 266 0.019
cellular lipid metabolic process GO:0044255 323 0.019
dephosphorylation GO:0016311 129 0.019
homeostasis of number of cells GO:0048872 210 0.019
lymphocyte differentiation GO:0030098 242 0.019
regulation of cell projection organization GO:0031344 206 0.019
negative regulation of vasculature development GO:1901343 26 0.018
neutrophil mediated cytotoxicity GO:0070942 8 0.018
Mouse
protein processing GO:0016485 163 0.018
regulation of blood pressure GO:0008217 93 0.018
Mouse
regulation of leukocyte differentiation GO:1902105 159 0.018
myotube cell development GO:0014904 60 0.018
protein ubiquitination GO:0016567 171 0.018
placenta development GO:0001890 140 0.018
myeloid leukocyte mediated immunity GO:0002444 42 0.017
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.017
t cell mediated immunity GO:0002456 50 0.017
Mouse
positive regulation of protein kinase activity GO:0045860 144 0.017
regulation of cell motility GO:2000145 236 0.017
nucleobase containing small molecule metabolic process GO:0055086 352 0.017
regulation of homeostatic process GO:0032844 182 0.017
response to peptide hormone GO:0043434 127 0.017
regulation of proteolysis GO:0030162 164 0.017
negative regulation of cell cycle GO:0045786 123 0.017
protein modification by small protein conjugation GO:0032446 187 0.017
regulation of establishment of protein localization GO:0070201 181 0.017
cellular protein catabolic process GO:0044257 155 0.017
cell killing GO:0001906 67 0.017
Mouse
neutrophil mediated immunity GO:0002446 19 0.017
Mouse
regulation of cell activation GO:0050865 289 0.017
t cell differentiation GO:0030217 174 0.017
inflammatory response GO:0006954 244 0.016
positive regulation of cytokine production GO:0001819 174 0.016
response to growth factor GO:0070848 198 0.016
reactive oxygen species metabolic process GO:0072593 84 0.016
regulation of skeletal muscle fiber development GO:0048742 36 0.016
regulation of eosinophil migration GO:2000416 2 0.016
regulation of hormone levels GO:0010817 211 0.016
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.016
chromatin organization GO:0006325 206 0.016
compound eye development GO:0048749 1 0.016
regulation of lymphocyte differentiation GO:0045619 107 0.016
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.016
Mouse
regulation of protein kinase activity GO:0045859 232 0.016
regulation of neural precursor cell proliferation GO:2000177 70 0.016
muscle cell differentiation GO:0042692 261 0.016
purine containing compound metabolic process GO:0072521 311 0.016
tissue homeostasis GO:0001894 115 0.016
regulation of neuron differentiation GO:0045664 281 0.016
regulation of muscle tissue development GO:1901861 97 0.016
sensory perception of chemical stimulus GO:0007606 51 0.016
killing of cells of other organism GO:0031640 13 0.016
Mouse
negative regulation of cellular component organization GO:0051129 194 0.016
regulation of myoblast differentiation GO:0045661 29 0.015
negative regulation of immune system process GO:0002683 209 0.015
multi multicellular organism process GO:0044706 109 0.015
positive regulation of stem cell proliferation GO:2000648 59 0.015
regulation of t cell activation GO:0050863 170 0.015
regulation of innate immune response GO:0045088 91 0.015
t cell mediated cytotoxicity GO:0001913 26 0.015
Mouse
myeloid cell homeostasis GO:0002262 114 0.015
t cell proliferation GO:0042098 120 0.015
response to light stimulus GO:0009416 135 0.015
regulation of cell adhesion GO:0030155 154 0.015
anatomical structure homeostasis GO:0060249 145 0.015
mapk cascade GO:0000165 281 0.015
negative regulation of protein modification process GO:0031400 163 0.015
regulation of protein transport GO:0051223 163 0.015
cellular response to organic cyclic compound GO:0071407 87 0.015
muscle fiber development GO:0048747 76 0.015
thymocyte migration GO:0072679 2 0.014
cellular response to cytokine stimulus GO:0071345 189 0.014
regulation of stem cell proliferation GO:0072091 78 0.014
positive regulation of protein phosphorylation GO:0001934 242 0.014
purine ribonucleotide metabolic process GO:0009150 290 0.014
negative regulation of intracellular signal transduction GO:1902532 167 0.014
alpha beta t cell activation GO:0046631 91 0.014
blood circulation GO:0008015 195 0.014
Mouse
muscle cell development GO:0055001 133 0.014
regulation of protein catabolic process GO:0042176 108 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
organic hydroxy compound metabolic process GO:1901615 203 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
regulation of protein localization GO:0032880 231 0.014
nucleoside phosphate metabolic process GO:0006753 338 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.014
membrane organization GO:0061024 245 0.014
negative regulation of protein phosphorylation GO:0001933 126 0.014
oxidation reduction process GO:0055114 342 0.014
fat cell differentiation GO:0045444 160 0.014
modification by host of symbiont morphology or physiology GO:0051851 12 0.014
Mouse
morphogenesis of a branching structure GO:0001763 203 0.014
chemotaxis GO:0006935 247 0.014
growth of symbiont involved in interaction with host GO:0044116 23 0.013
Mouse
regulation of organelle organization GO:0033043 289 0.013
negative regulation of muscle cell differentiation GO:0051148 33 0.013
germ cell development GO:0007281 185 0.013
endomembrane system organization GO:0010256 147 0.013
rho protein signal transduction GO:0007266 32 0.013
response to oxygen levels GO:0070482 62 0.013
regulation of inflammatory response GO:0050727 147 0.013
regulation of cell cycle process GO:0010564 160 0.013
gland development GO:0048732 330 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
nitrogen compound transport GO:0071705 271 0.013
activation of mapk activity involved in innate immune response GO:0035419 2 0.013
positive regulation of proteolysis GO:0045862 85 0.013
regulation of secretion by cell GO:1903530 249 0.013
ubiquitin dependent protein catabolic process GO:0006511 129 0.013
positive regulation of cell motility GO:2000147 116 0.013
negative regulation of phosphate metabolic process GO:0045936 184 0.013
peptidyl serine modification GO:0018209 83 0.013
response to organonitrogen compound GO:0010243 246 0.013
carbohydrate derivative biosynthetic process GO:1901137 183 0.013
interspecies interaction between organisms GO:0044419 83 0.013
Mouse
ribose phosphate metabolic process GO:0019693 291 0.013
lipid biosynthetic process GO:0008610 179 0.013
multicellular organism growth GO:0035264 161 0.013
embryonic placenta development GO:0001892 98 0.013
negative regulation of molecular function GO:0044092 258 0.013
posttranscriptional regulation of gene expression GO:0010608 155 0.013
cellular homeostasis GO:0019725 240 0.013
heart morphogenesis GO:0003007 178 0.012
ribonucleotide metabolic process GO:0009259 291 0.012
positive regulation of cellular catabolic process GO:0031331 148 0.012
multicellular organismal homeostasis GO:0048871 164 0.012
regulation of striated muscle cell differentiation GO:0051153 81 0.012
microtubule based process GO:0007017 236 0.012
circulatory system process GO:0003013 197 0.012
Mouse
positive regulation of cell migration GO:0030335 109 0.012
myoblast differentiation GO:0045445 52 0.012
axon ensheathment GO:0008366 76 0.012
innate immune response GO:0045087 157 0.012
cellular chemical homeostasis GO:0055082 215 0.012
regulation of interleukin 10 secretion GO:2001179 4 0.012
protein acylation GO:0043543 64 0.012
regulation of cellular catabolic process GO:0031329 242 0.012
monocarboxylic acid metabolic process GO:0032787 191 0.012
regulation of lipid metabolic process GO:0019216 118 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
immune response regulating signaling pathway GO:0002764 125 0.012
multicellular organismal signaling GO:0035637 91 0.012
inter male aggressive behavior GO:0002121 3 0.012
regulation of response to wounding GO:1903034 189 0.012
maintenance of location GO:0051235 89 0.012
extracellular matrix organization GO:0030198 147 0.012
regulation of reactive oxygen species metabolic process GO:2000377 40 0.012
spermatid development GO:0007286 108 0.012
extracellular structure organization GO:0043062 148 0.012
cell substrate adhesion GO:0031589 130 0.012
response to peptide GO:1901652 136 0.012
activation of immune response GO:0002253 138 0.012
positive regulation of cell projection organization GO:0031346 95 0.012
leukocyte apoptotic process GO:0071887 71 0.012
regulation of cellular response to stress GO:0080135 159 0.012
transmission of nerve impulse GO:0019226 76 0.012
histone modification GO:0016570 159 0.012
b cell activation GO:0042113 161 0.012
intracellular protein transport GO:0006886 204 0.012
detection of chemical stimulus involved in sensory perception of smell GO:0050911 4 0.012
regulation of mitotic cell cycle GO:0007346 126 0.012
cellular response to molecule of bacterial origin GO:0071219 83 0.011
response to steroid hormone GO:0048545 56 0.011
negative regulation of multi organism process GO:0043901 68 0.011
Mouse
positive regulation of protein oligomerization GO:0032461 4 0.011
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.011
negative regulation of angiogenesis GO:0016525 25 0.011
cytoplasmic transport GO:0016482 234 0.011
positive regulation of eosinophil migration GO:2000418 2 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
cellular response to acid chemical GO:0071229 68 0.011
response to transforming growth factor beta GO:0071559 88 0.011
positive regulation of thymocyte migration GO:2000412 2 0.011
positive regulation of lymphocyte activation GO:0051251 140 0.011
organ regeneration GO:0031100 2 0.011
cognition GO:0050890 149 0.011
purine nucleotide metabolic process GO:0006163 302 0.011
cellular response to peptide GO:1901653 92 0.011
peptidyl tyrosine phosphorylation GO:0018108 143 0.011
cellular response to peptide hormone stimulus GO:0071375 92 0.011
ensheathment of neurons GO:0007272 76 0.011
hematopoietic progenitor cell differentiation GO:0002244 143 0.011
cellular protein complex assembly GO:0043623 116 0.011
negative regulation of cell motility GO:2000146 61 0.011
neuronal action potential GO:0019228 54 0.011
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.011
immune response activating signal transduction GO:0002757 116 0.011
leukocyte migration GO:0050900 124 0.011
neural precursor cell proliferation GO:0061351 121 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
regulation of mapk cascade GO:0043408 248 0.011
connective tissue development GO:0061448 179 0.011
epithelial cell development GO:0002064 159 0.011
cellular response to lipid GO:0071396 145 0.011
positive regulation of defense response GO:0031349 124 0.011
glycoprotein metabolic process GO:0009100 116 0.011
regulation of anatomical structure size GO:0090066 178 0.011
regulation of purine nucleotide metabolic process GO:1900542 169 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
ras protein signal transduction GO:0007265 77 0.011
lateral inhibition GO:0046331 1 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
gonad development GO:0008406 141 0.011
ameboidal type cell migration GO:0001667 128 0.011
sprouting angiogenesis GO:0002040 26 0.011
cellular response to dna damage stimulus GO:0006974 207 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.011
negative regulation of growth of symbiont involved in interaction with host GO:0044146 19 0.011
Mouse
single organismal cell cell adhesion GO:0016337 131 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.010
Mouse
camera type eye development GO:0043010 266 0.010
action potential GO:0001508 78 0.010
interaction with symbiont GO:0051702 14 0.010
Mouse
negative regulation of nervous system development GO:0051961 156 0.010
cellular carbohydrate metabolic process GO:0044262 119 0.010
regulation of protein oligomerization GO:0032459 4 0.010
myeloid cell differentiation GO:0030099 233 0.010
negative regulation of phosphorus metabolic process GO:0010563 184 0.010
cardiac muscle tissue development GO:0048738 130 0.010
alcohol metabolic process GO:0006066 116 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.010
Mouse
response to acid chemical GO:0001101 111 0.010
leukocyte chemotaxis GO:0030595 69 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.010
covalent chromatin modification GO:0016569 163 0.010
developmental maturation GO:0021700 193 0.010
regulation of system process GO:0044057 200 0.010
lymphocyte apoptotic process GO:0070227 54 0.010
lymphocyte proliferation GO:0046651 164 0.010
cell growth GO:0016049 130 0.010
response to insulin GO:0032868 100 0.010
glycoprotein biosynthetic process GO:0009101 89 0.010
negative regulation of protein processing GO:0010955 79 0.010
cellular response to growth factor stimulus GO:0071363 197 0.010
negative regulation of lymphocyte activation GO:0051250 91 0.010
organophosphate biosynthetic process GO:0090407 122 0.010
tissue remodeling GO:0048771 102 0.010
positive regulation of cell death GO:0010942 224 0.010
protein targeting GO:0006605 143 0.010
activation of nf kappab inducing kinase activity GO:0007250 4 0.010

Gzme disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.018
nervous system disease DOID:863 0 0.018
disease of metabolism DOID:0014667 0 0.011
musculoskeletal system disease DOID:17 0 0.011