Mus musculus

44 known processes

Hadha

hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

(Aliases: C77020,Mtpa)

Hadha biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
monocarboxylic acid metabolic process GO:0032787 191 0.596
fatty acid oxidation GO:0019395 28 0.574
oxidation reduction process GO:0055114 342 0.472
lipid oxidation GO:0034440 29 0.424
acyl coa metabolic process GO:0006637 19 0.341
cellular lipid metabolic process GO:0044255 323 0.293
lipid modification GO:0030258 65 0.269
very long chain fatty acid catabolic process GO:0042760 2 0.263
cellular lipid catabolic process GO:0044242 52 0.227
fatty acid beta oxidation GO:0006635 16 0.194
small molecule catabolic process GO:0044282 71 0.141
monocarboxylic acid catabolic process GO:0072329 27 0.118
lipid catabolic process GO:0016042 69 0.113
fatty acid metabolic process GO:0006631 121 0.111
membrane organization GO:0061024 245 0.095
organic acid catabolic process GO:0016054 51 0.089
carboxylic acid catabolic process GO:0046395 51 0.088
very long chain fatty acid metabolic process GO:0000038 8 0.082
cellular ketone metabolic process GO:0042180 84 0.077
regulation of cellular ketone metabolic process GO:0010565 66 0.076
thioester metabolic process GO:0035383 19 0.072
cation transport GO:0006812 399 0.065
sterol metabolic process GO:0016125 58 0.062
fatty acid catabolic process GO:0009062 25 0.062
purine ribonucleotide metabolic process GO:0009150 290 0.060
organic hydroxy compound metabolic process GO:1901615 203 0.060
lipid biosynthetic process GO:0008610 179 0.059
regulation of organelle organization GO:0033043 289 0.056
small molecule biosynthetic process GO:0044283 132 0.056
nucleoside phosphate metabolic process GO:0006753 338 0.054
organic cyclic compound catabolic process GO:1901361 295 0.053
cellular amine metabolic process GO:0044106 44 0.052
organic acid biosynthetic process GO:0016053 86 0.049
ribonucleotide catabolic process GO:0009261 208 0.049
regulation of cellular amino acid metabolic process GO:0006521 5 0.048
ribonucleotide metabolic process GO:0009259 291 0.045
organonitrogen compound catabolic process GO:1901565 264 0.044
coenzyme metabolic process GO:0006732 52 0.041
nucleotide metabolic process GO:0009117 332 0.041
mitochondrion organization GO:0007005 134 0.041
transmembrane transport GO:0055085 412 0.041
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.040
cellular nitrogen compound catabolic process GO:0044270 280 0.040
regulation of apoptotic signaling pathway GO:2001233 197 0.039
ribonucleoside metabolic process GO:0009119 245 0.037
t cell activation GO:0042110 289 0.037
mitochondrial membrane organization GO:0007006 26 0.036
amine metabolic process GO:0009308 45 0.036
endomembrane system organization GO:0010256 147 0.036
apoptotic signaling pathway GO:0097190 306 0.035
cell adhesion GO:0007155 329 0.033
regulation of cellular amine metabolic process GO:0033238 20 0.033
cation homeostasis GO:0055080 212 0.033
organophosphate catabolic process GO:0046434 232 0.032
ion transmembrane transport GO:0034220 361 0.032
protein targeting GO:0006605 143 0.032
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.032
ribose phosphate metabolic process GO:0019693 291 0.031
regulation of fatty acid oxidation GO:0046320 10 0.031
purine ribonucleoside metabolic process GO:0046128 241 0.031
purine nucleoside metabolic process GO:0042278 241 0.031
cofactor metabolic process GO:0051186 80 0.030
response to nutrient levels GO:0031667 109 0.029
purine nucleotide catabolic process GO:0006195 211 0.029
nucleoside triphosphate catabolic process GO:0009143 205 0.029
aromatic compound catabolic process GO:0019439 286 0.029
response to organic cyclic compound GO:0014070 198 0.029
carboxylic acid transport GO:0046942 100 0.029
cation transmembrane transport GO:0098655 266 0.029
carbohydrate derivative catabolic process GO:1901136 231 0.028
organic anion transport GO:0015711 137 0.028
dicarboxylic acid catabolic process GO:0043649 2 0.028
response to starvation GO:0042594 65 0.028
regulation of lymphocyte activation GO:0051249 240 0.028
nucleotide catabolic process GO:0009166 217 0.028
carboxylic acid biosynthetic process GO:0046394 86 0.027
purine nucleotide metabolic process GO:0006163 302 0.027
heterocycle catabolic process GO:0046700 280 0.027
ribonucleoside triphosphate metabolic process GO:0009199 220 0.027
apoptotic mitochondrial changes GO:0008637 48 0.027
cellular amino acid metabolic process GO:0006520 103 0.027
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 0.027
purine nucleoside triphosphate catabolic process GO:0009146 203 0.027
regulation of cell activation GO:0050865 289 0.026
carbohydrate derivative biosynthetic process GO:1901137 183 0.026
leukocyte differentiation GO:0002521 342 0.026
purine nucleoside triphosphate metabolic process GO:0009144 226 0.026
protein processing GO:0016485 163 0.025
purine containing compound catabolic process GO:0072523 213 0.025
nucleoside metabolic process GO:0009116 246 0.025
microtubule based process GO:0007017 236 0.025
multicellular organismal signaling GO:0035637 91 0.025
intracellular protein transport GO:0006886 204 0.025
germ cell development GO:0007281 185 0.025
forebrain development GO:0030900 302 0.025
purine nucleoside monophosphate metabolic process GO:0009126 81 0.025
negative regulation of cellular protein metabolic process GO:0032269 247 0.025
cellular ion homeostasis GO:0006873 165 0.025
regulation of mitochondrion organization GO:0010821 27 0.025
negative regulation of organelle organization GO:0010639 90 0.025
nucleobase containing small molecule metabolic process GO:0055086 352 0.024
purine nucleoside catabolic process GO:0006152 205 0.024
purine nucleoside monophosphate catabolic process GO:0009128 58 0.024
lymphocyte proliferation GO:0046651 164 0.024
alcohol metabolic process GO:0006066 116 0.024
anion transport GO:0006820 177 0.024
nucleoside catabolic process GO:0009164 206 0.024
cytokine production GO:0001816 319 0.024
nucleoside phosphate catabolic process GO:1901292 222 0.023
cellular chemical homeostasis GO:0055082 215 0.023
glycosyl compound catabolic process GO:1901658 206 0.023
positive regulation of lymphocyte activation GO:0051251 140 0.023
cellular homeostasis GO:0019725 240 0.023
ribonucleoside catabolic process GO:0042454 206 0.023
regulation of hormone levels GO:0010817 211 0.023
purine containing compound metabolic process GO:0072521 311 0.023
negative regulation of fatty acid oxidation GO:0046322 5 0.023
actin cytoskeleton organization GO:0030036 220 0.022
male gamete generation GO:0048232 285 0.022
protein maturation GO:0051604 176 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
regulation of intracellular transport GO:0032386 159 0.022
regulation of fatty acid metabolic process GO:0019217 28 0.022
response to organonitrogen compound GO:0010243 246 0.022
ribonucleoside triphosphate catabolic process GO:0009203 199 0.022
succinyl coa metabolic process GO:0006104 1 0.022
regulation of cellular response to stress GO:0080135 159 0.022
response to oxygen levels GO:0070482 62 0.022
cell type specific apoptotic process GO:0097285 268 0.022
purine ribonucleoside catabolic process GO:0046130 205 0.022
ossification GO:0001503 216 0.021
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.021
metal ion homeostasis GO:0055065 189 0.021
cellular divalent inorganic cation homeostasis GO:0072503 127 0.021
cellular response to hormone stimulus GO:0032870 150 0.021
regulation of lipid metabolic process GO:0019216 118 0.021
transmission of nerve impulse GO:0019226 76 0.021
glycosyl compound metabolic process GO:1901657 246 0.021
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
immune effector process GO:0002252 321 0.021
positive regulation of growth GO:0045927 104 0.021
reactive nitrogen species metabolic process GO:2001057 0 0.021
small gtpase mediated signal transduction GO:0007264 97 0.021
sulfur compound metabolic process GO:0006790 100 0.021
adiponectin activated signaling pathway GO:0033211 4 0.020
response to peptide GO:1901652 136 0.020
plasma membrane organization GO:0007009 90 0.020
regulation of cellular component biogenesis GO:0044087 181 0.020
regulation of t cell activation GO:0050863 170 0.020
oocyte axis specification GO:0007309 2 0.020
regulation of cytokine production GO:0001817 266 0.020
negative regulation of fatty acid metabolic process GO:0045922 10 0.020
blood vessel morphogenesis GO:0048514 285 0.020
carnitine metabolic process GO:0009437 7 0.020
inflammatory response GO:0006954 244 0.020
actin filament organization GO:0007015 113 0.020
spermatogenesis GO:0007283 284 0.020
regulation of secretion by cell GO:1903530 249 0.019
regulation of neuron differentiation GO:0045664 281 0.019
protein oligomerization GO:0051259 67 0.019
protein localization to membrane GO:0072657 108 0.019
negative regulation of molecular function GO:0044092 258 0.019
cellular alcohol metabolic process GO:0044107 3 0.019
epithelial cell development GO:0002064 159 0.019
positive regulation of protein phosphorylation GO:0001934 242 0.019
organic acid transport GO:0015849 101 0.019
inorganic cation transmembrane transport GO:0098662 207 0.019
macromolecule catabolic process GO:0009057 281 0.019
nucleoside monophosphate metabolic process GO:0009123 85 0.019
regulation of vacuole organization GO:0044088 4 0.019
regulation of cellular catabolic process GO:0031329 242 0.019
neuronal action potential GO:0019228 54 0.019
homeostasis of number of cells GO:0048872 210 0.019
citrate metabolic process GO:0006101 3 0.019
oocyte construction GO:0007308 2 0.019
innate immune response GO:0045087 157 0.018
angiogenesis GO:0001525 201 0.018
maintenance of location GO:0051235 89 0.018
Worm
cellular response to extracellular stimulus GO:0031668 81 0.018
peptidyl amino acid modification GO:0018193 336 0.018
single organism cell adhesion GO:0098602 156 0.018
inorganic ion transmembrane transport GO:0098660 234 0.018
organelle localization GO:0051640 179 0.018
negative regulation of protein metabolic process GO:0051248 282 0.018
negative regulation of intracellular transport GO:0032387 38 0.018
organonitrogen compound biosynthetic process GO:1901566 192 0.018
regulation of membrane potential GO:0042391 192 0.017
defense response to other organism GO:0098542 197 0.017
ether metabolic process GO:0018904 2 0.017
cytoplasmic transport GO:0016482 234 0.017
cellular response to cytokine stimulus GO:0071345 189 0.017
negative regulation of cell proliferation GO:0008285 296 0.017
glycerolipid metabolic process GO:0046486 122 0.017
renal system development GO:0072001 225 0.017
positive regulation of cell activation GO:0050867 158 0.017
positive regulation of cell death GO:0010942 224 0.017
nucleoside triphosphate metabolic process GO:0009141 230 0.017
cellular response to organonitrogen compound GO:0071417 145 0.017
dna metabolic process GO:0006259 303 0.017
divalent inorganic cation transport GO:0072511 178 0.017
organophosphate biosynthetic process GO:0090407 122 0.016
regulation of protein localization GO:0032880 231 0.016
divalent metal ion transport GO:0070838 172 0.016
purine ribonucleotide catabolic process GO:0009154 208 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.016
intracellular mrna localization GO:0008298 4 0.016
protein modification by small protein conjugation GO:0032446 187 0.016
protein catabolic process GO:0030163 221 0.016
regulation of leukocyte differentiation GO:1902105 159 0.016
lymphocyte differentiation GO:0030098 242 0.016
positive regulation of cell development GO:0010720 237 0.016
response to decreased oxygen levels GO:0036293 59 0.015
skin development GO:0043588 220 0.015
nitrogen compound transport GO:0071705 271 0.015
multicellular organismal homeostasis GO:0048871 164 0.015
regulation of body fluid levels GO:0050878 162 0.015
action potential GO:0001508 78 0.015
multicellular organism growth GO:0035264 161 0.015
urogenital system development GO:0001655 261 0.015
regulation of lymphocyte proliferation GO:0050670 117 0.015
generation of precursor metabolites and energy GO:0006091 103 0.015
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.015
regulation of cell adhesion GO:0030155 154 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.015
glutamine family amino acid biosynthetic process GO:0009084 2 0.015
sensory organ morphogenesis GO:0090596 242 0.015
cellular response to external stimulus GO:0071496 88 0.015
macroautophagy GO:0016236 21 0.015
acylglycerol metabolic process GO:0006639 55 0.015
metencephalon development GO:0022037 89 0.015
amide transport GO:0042886 138 0.015
glycoprotein metabolic process GO:0009100 116 0.015
regulation of fatty acid biosynthetic process GO:0042304 12 0.015
regulation of homeostatic process GO:0032844 182 0.015
leukocyte activation involved in immune response GO:0002366 126 0.015
sensory perception GO:0007600 245 0.014
regulation of establishment of protein localization GO:0070201 181 0.014
protein localization to nucleus GO:0034504 121 0.014
regulation of neuron projection development GO:0010975 169 0.014
steroid metabolic process GO:0008202 119 0.014
positive regulation of nervous system development GO:0051962 221 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.014
compound eye development GO:0048749 1 0.014
regulation of mapk cascade GO:0043408 248 0.014
coenzyme a metabolic process GO:0015936 8 0.014
regulation of system process GO:0044057 200 0.014
regulation of protein transport GO:0051223 163 0.014
diterpenoid metabolic process GO:0016101 24 0.014
cellular calcium ion homeostasis GO:0006874 119 0.014
response to monosaccharide GO:0034284 67 0.014
response to extracellular stimulus GO:0009991 127 0.014
t cell proliferation GO:0042098 120 0.014
negative regulation of cellular component organization GO:0051129 194 0.014
positive regulation of protein modification process GO:0031401 299 0.014
skeletal system development GO:0001501 356 0.014
ribonucleoside monophosphate catabolic process GO:0009158 57 0.014
regulation of kinase activity GO:0043549 249 0.013
protein secretion GO:0009306 111 0.013
nucleoside monophosphate catabolic process GO:0009125 59 0.013
developmental maturation GO:0021700 193 0.013
organelle assembly GO:0070925 177 0.013
ribonucleoside monophosphate metabolic process GO:0009161 80 0.013
glucose homeostasis GO:0042593 128 0.013
mapk cascade GO:0000165 281 0.013
placenta development GO:0001890 140 0.013
wound healing GO:0042060 157 0.013
regulation of secretion GO:0051046 274 0.013
regulation of cell motility GO:2000145 236 0.013
regulation of cell projection organization GO:0031344 206 0.013
t cell differentiation GO:0030217 174 0.013
ras protein signal transduction GO:0007265 77 0.013
cellular metal ion homeostasis GO:0006875 151 0.013
regulation of fatty acid beta oxidation GO:0031998 1 0.013
protein modification by small protein conjugation or removal GO:0070647 207 0.013
carbohydrate metabolic process GO:0005975 230 0.013
carbohydrate homeostasis GO:0033500 128 0.013
dephosphorylation GO:0016311 129 0.013
mitotic cell cycle GO:0000278 195 0.013
regulation of hydrolase activity GO:0051336 246 0.013
protein ubiquitination GO:0016567 171 0.013
calcium ion homeostasis GO:0055074 127 0.013
response to drug GO:0042493 75 0.013
glutamate metabolic process GO:0006536 9 0.013
regulation of ion transport GO:0043269 215 0.013
cholesterol metabolic process GO:0008203 56 0.013
peptide transport GO:0015833 133 0.012
response to oxidative stress GO:0006979 123 0.012
myeloid cell differentiation GO:0030099 233 0.012
cellularization GO:0007349 1 0.012
cellular macromolecule catabolic process GO:0044265 206 0.012
muscle cell differentiation GO:0042692 261 0.012
regulation of leukocyte proliferation GO:0070663 121 0.012
nadh metabolic process GO:0006734 1 0.012
striated muscle tissue development GO:0014706 293 0.012
regulation of protein kinase activity GO:0045859 232 0.012
rna interference GO:0016246 2 0.012
regulation of lipid biosynthetic process GO:0046890 54 0.012
positive regulation of secretion by cell GO:1903532 114 0.012
nucleoside phosphate biosynthetic process GO:1901293 79 0.012
cell activation involved in immune response GO:0002263 126 0.012
regulation of response to wounding GO:1903034 189 0.012
negative regulation of intracellular signal transduction GO:1902532 167 0.012
regulation of leukocyte apoptotic process GO:2000106 56 0.012
ensheathment of neurons GO:0007272 76 0.012
hematopoietic progenitor cell differentiation GO:0002244 143 0.012
cellular response to nutrient levels GO:0031669 64 0.012
intrinsic apoptotic signaling pathway GO:0097193 132 0.012
circulatory system process GO:0003013 197 0.012
mitotic cell cycle process GO:1903047 159 0.012
regulation of proteolysis GO:0030162 164 0.012
endocytosis GO:0006897 168 0.012
Worm
cerebellum development GO:0021549 77 0.012
negative regulation of phosphate metabolic process GO:0045936 184 0.012
leukocyte proliferation GO:0070661 172 0.012
establishment of protein localization to membrane GO:0090150 54 0.012
defense response to bacterium GO:0042742 119 0.012
connective tissue development GO:0061448 179 0.012
axon ensheathment GO:0008366 76 0.012
regulation of autophagic vacuole assembly GO:2000785 4 0.012
positive regulation of immune effector process GO:0002699 107 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
muscle tissue development GO:0060537 308 0.012
negative regulation of cell development GO:0010721 169 0.012
positive regulation of fatty acid oxidation GO:0046321 4 0.012
negative regulation of cellular amine metabolic process GO:0033239 1 0.011
gland development GO:0048732 330 0.011
hindbrain development GO:0030902 128 0.011
camera type eye development GO:0043010 266 0.011
neutral lipid metabolic process GO:0006638 57 0.011
positive regulation of neuron differentiation GO:0045666 141 0.011
regulation of t cell proliferation GO:0042129 92 0.011
positive regulation of cell projection organization GO:0031346 95 0.011
multi multicellular organism process GO:0044706 109 0.011
positive regulation of organelle organization GO:0010638 128 0.011
glutamate biosynthetic process GO:0006537 2 0.011
fatty acid transmembrane transport GO:1902001 1 0.011
regulation of reactive oxygen species metabolic process GO:2000377 40 0.011
positive regulation of apoptotic process GO:0043065 217 0.011
positive regulation of programmed cell death GO:0043068 218 0.011
kidney development GO:0001822 213 0.011
epithelial cell proliferation GO:0050673 174 0.011
calcium ion transport GO:0006816 159 0.011
regulation of ion transmembrane transport GO:0034765 119 0.011
response to hypoxia GO:0001666 58 0.011
positive regulation of mitochondrial membrane permeability GO:0035794 12 0.011
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.011
ribonucleoside bisphosphate metabolic process GO:0033875 9 0.011
regulation of cell cycle GO:0051726 281 0.011
regulation of protein catabolic process GO:0042176 108 0.011
lateral inhibition GO:0046331 1 0.011
cell growth GO:0016049 130 0.011
single organismal cell cell adhesion GO:0016337 131 0.011
regulation of metal ion transport GO:0010959 106 0.011
fatty acid biosynthetic process GO:0006633 41 0.011
regulation of defense response GO:0031347 233 0.011
sequestering of calcium ion GO:0051208 18 0.011
g protein coupled receptor signaling pathway GO:0007186 243 0.011
lymphocyte activation involved in immune response GO:0002285 93 0.011
myelination GO:0042552 74 0.011
response to growth factor GO:0070848 198 0.011
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.011
nuclear transport GO:0051169 139 0.011
mitochondrial transport GO:0006839 36 0.011
cellular response to growth factor stimulus GO:0071363 197 0.011
glycerophospholipid metabolic process GO:0006650 71 0.011
lymphocyte homeostasis GO:0002260 64 0.011
negative regulation of apoptotic signaling pathway GO:2001234 104 0.011
zygotic determination of anterior posterior axis embryo GO:0007354 3 0.011
hormone secretion GO:0046879 128 0.010
organelle fission GO:0048285 170 0.010
cellular protein complex assembly GO:0043623 116 0.010
tricarboxylic acid metabolic process GO:0072350 5 0.010
divalent inorganic cation homeostasis GO:0072507 138 0.010
lipid localization GO:0010876 126 0.010
Worm
tissue homeostasis GO:0001894 115 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.010
leukocyte apoptotic process GO:0071887 71 0.010
myeloid leukocyte differentiation GO:0002573 119 0.010
spermatid differentiation GO:0048515 115 0.010
establishment of organelle localization GO:0051656 122 0.010
regulation of vesicle mediated transport GO:0060627 139 0.010
microtubule based transport GO:0010970 50 0.010
regulation of cholesterol metabolic process GO:0090181 14 0.010
negative regulation of protein modification process GO:0031400 163 0.010
gonad development GO:0008406 141 0.010
positive regulation of cytokine production GO:0001819 174 0.010
wnt signaling pathway GO:0016055 188 0.010
phospholipid metabolic process GO:0006644 87 0.010

Hadha disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.036
disease of anatomical entity DOID:7 0 0.026
nervous system disease DOID:863 0 0.026
inherited metabolic disorder DOID:655 0 0.021
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.014
immune system disease DOID:2914 0 0.011
sensory system disease DOID:0050155 0 0.010