Mus musculus

113 known processes

Hdac6

histone deacetylase 6

(Aliases: Sfc6,Hd6,Hdac5,mHDA2)

Hdac6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein removal GO:0070646 21 0.912
modification dependent macromolecule catabolic process GO:0043632 133 0.775
cellular macromolecule catabolic process GO:0044265 206 0.604
protein deubiquitination GO:0016579 19 0.575
macromolecule catabolic process GO:0009057 281 0.559
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.484
cellular protein catabolic process GO:0044257 155 0.434
histone modification GO:0016570 159 0.417
dna repair GO:0006281 107 0.407
cellular response to dna damage stimulus GO:0006974 207 0.352
covalent chromatin modification GO:0016569 163 0.345
protein catabolic process GO:0030163 221 0.341
protein modification by small protein conjugation or removal GO:0070647 207 0.341
ubiquitin dependent protein catabolic process GO:0006511 129 0.324
protein modification by small protein conjugation GO:0032446 187 0.262
cellular response to misfolded protein GO:0071218 5 0.221
double strand break repair via nonhomologous end joining GO:0006303 10 0.192
protein ubiquitination GO:0016567 171 0.192
protein localization to organelle GO:0033365 185 0.188
double strand break repair GO:0006302 48 0.174
modification dependent protein catabolic process GO:0019941 133 0.161
glycosyl compound metabolic process GO:1901657 246 0.127
intracellular protein transport GO:0006886 204 0.117
Human
cytoplasmic transport GO:0016482 234 0.108
organonitrogen compound catabolic process GO:1901565 264 0.098
translesion synthesis GO:0019985 1 0.098
ribonucleotide metabolic process GO:0009259 291 0.096
nucleobase containing small molecule metabolic process GO:0055086 352 0.090
organelle disassembly GO:1903008 2 0.089
chromatin modification GO:0016568 187 0.089
aromatic compound catabolic process GO:0019439 286 0.088
mitotic cell cycle process GO:1903047 159 0.087
positive regulation of protein modification process GO:0031401 299 0.085
chromatin organization GO:0006325 206 0.084
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.084
purine ribonucleotide catabolic process GO:0009154 208 0.080
cellular homeostasis GO:0019725 240 0.079
transmembrane transport GO:0055085 412 0.075
cellular ketone metabolic process GO:0042180 84 0.075
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.074
histone deubiquitination GO:0016578 2 0.074
ribonucleoside triphosphate catabolic process GO:0009203 199 0.073
ribonucleoside triphosphate metabolic process GO:0009199 220 0.072
regulation of proteolysis GO:0030162 164 0.071
Human
purine nucleoside catabolic process GO:0006152 205 0.069
membrane organization GO:0061024 245 0.067
nucleoside triphosphate metabolic process GO:0009141 230 0.066
establishment of organelle localization GO:0051656 122 0.063
carbohydrate derivative catabolic process GO:1901136 231 0.062
organelle membrane fusion GO:0090174 1 0.062
nucleotide catabolic process GO:0009166 217 0.061
histone methylation GO:0016571 71 0.061
ion transmembrane transport GO:0034220 361 0.058
nucleoside phosphate metabolic process GO:0006753 338 0.058
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.056
small gtpase mediated signal transduction GO:0007264 97 0.056
positive regulation of cellular protein catabolic process GO:1903364 34 0.055
development of primary sexual characteristics GO:0045137 143 0.054
organic cyclic compound catabolic process GO:1901361 295 0.054
response to radiation GO:0009314 165 0.054
nitrogen compound transport GO:0071705 271 0.054
nucleoside triphosphate catabolic process GO:0009143 205 0.053
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.053
purine nucleoside metabolic process GO:0042278 241 0.052
regulation of cellular catabolic process GO:0031329 242 0.052
nucleotide metabolic process GO:0009117 332 0.052
meiotic nuclear division GO:0007126 115 0.051
regulation of peptidase activity GO:0052547 96 0.050
heterocycle catabolic process GO:0046700 280 0.050
purine containing compound metabolic process GO:0072521 311 0.049
glycosyl compound catabolic process GO:1901658 206 0.049
response to misfolded protein GO:0051788 5 0.048
dna metabolic process GO:0006259 303 0.047
regulation of cell cycle GO:0051726 281 0.047
negative regulation of protein metabolic process GO:0051248 282 0.047
Human
microtubule cytoskeleton organization GO:0000226 157 0.046
positive regulation of protein catabolic process GO:0045732 60 0.046
purine nucleotide metabolic process GO:0006163 302 0.045
cellular nitrogen compound catabolic process GO:0044270 280 0.044
positive regulation of hydrolase activity GO:0051345 148 0.044
ribonucleoside metabolic process GO:0009119 245 0.043
ribose phosphate metabolic process GO:0019693 291 0.041
purine nucleoside triphosphate metabolic process GO:0009144 226 0.041
cellular amide metabolic process GO:0043603 58 0.040
purine nucleoside triphosphate catabolic process GO:0009146 203 0.040
mitotic cell cycle GO:0000278 195 0.039
nucleoside metabolic process GO:0009116 246 0.039
nuclear transport GO:0051169 139 0.039
proteasomal protein catabolic process GO:0010498 98 0.038
ribonucleoside monophosphate catabolic process GO:0009158 57 0.038
purine ribonucleotide metabolic process GO:0009150 290 0.038
regulation of cellular protein catabolic process GO:1903362 61 0.038
nucleoside catabolic process GO:0009164 206 0.037
antimicrobial peptide production GO:0002775 2 0.037
protein targeting GO:0006605 143 0.037
learning or memory GO:0007611 148 0.035
ribonucleotide catabolic process GO:0009261 208 0.035
protein import into nucleus GO:0006606 95 0.035
positive regulation of apoptotic process GO:0043065 217 0.035
dna biosynthetic process GO:0071897 22 0.035
attachment of spindle microtubules to kinetochore GO:0008608 4 0.034
regulation of endopeptidase activity GO:0052548 89 0.033
protein maturation GO:0051604 176 0.032
Human
nucleoside phosphate catabolic process GO:1901292 222 0.032
regulation of protein deubiquitination GO:0090085 1 0.032
non recombinational repair GO:0000726 10 0.032
protein k63 linked deubiquitination GO:0070536 1 0.031
cation transport GO:0006812 399 0.031
macromolecule methylation GO:0043414 120 0.031
peptide metabolic process GO:0006518 46 0.031
regulation of microtubule cytoskeleton organization GO:0070507 37 0.031
gland development GO:0048732 330 0.031
male gamete generation GO:0048232 285 0.030
purine ribonucleoside catabolic process GO:0046130 205 0.030
immune effector process GO:0002252 321 0.030
purine nucleotide catabolic process GO:0006195 211 0.030
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.030
regulation of transferase activity GO:0051338 263 0.030
tube closure GO:0060606 91 0.029
nuclear import GO:0051170 95 0.029
purine containing compound catabolic process GO:0072523 213 0.029
primary neural tube formation GO:0014020 95 0.029
nucleoside monophosphate catabolic process GO:0009125 59 0.028
negative regulation of cell proliferation GO:0008285 296 0.028
ribonucleoside catabolic process GO:0042454 206 0.028
response to light stimulus GO:0009416 135 0.028
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.028
spermatogenesis GO:0007283 284 0.028
organophosphate catabolic process GO:0046434 232 0.028
regulation of mitotic cell cycle GO:0007346 126 0.027
neural tube development GO:0021915 160 0.027
positive regulation of organelle organization GO:0010638 128 0.027
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.027
organic anion transport GO:0015711 137 0.027
regulation of peptide transport GO:0090087 91 0.027
positive regulation of cellular catabolic process GO:0031331 148 0.026
inclusion body assembly GO:0070841 3 0.026
positive regulation of binding GO:0051099 49 0.026
positive regulation of protein phosphorylation GO:0001934 242 0.025
regulation of protein localization GO:0032880 231 0.025
nucleocytoplasmic transport GO:0006913 139 0.025
protein complex disassembly GO:0043241 40 0.025
multicellular organism growth GO:0035264 161 0.025
purine ribonucleoside metabolic process GO:0046128 241 0.025
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 25 0.025
wnt signaling pathway GO:0016055 188 0.025
regulation of mapk cascade GO:0043408 248 0.025
maintenance of location GO:0051235 89 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.025
regulation of protein transport GO:0051223 163 0.025
cellular response to inorganic substance GO:0071241 37 0.025
regulation of intracellular transport GO:0032386 159 0.024
regulation of microtubule based process GO:0032886 52 0.024
dephosphorylation GO:0016311 129 0.024
response to uv GO:0009411 44 0.024
cell type specific apoptotic process GO:0097285 268 0.024
atp catabolic process GO:0006200 55 0.024
regulation of protein import into nucleus GO:0042306 52 0.024
anatomical structure homeostasis GO:0060249 145 0.024
anion transport GO:0006820 177 0.024
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.024
neural tube closure GO:0001843 90 0.023
negative regulation of nervous system development GO:0051961 156 0.023
negative regulation of intracellular signal transduction GO:1902532 167 0.023
positive regulation of cell death GO:0010942 224 0.023
Human
regulation of intracellular protein transport GO:0033157 82 0.023
mapk cascade GO:0000165 281 0.023
establishment of protein localization to organelle GO:0072594 118 0.023
cellular amino acid metabolic process GO:0006520 103 0.023
rho protein signal transduction GO:0007266 32 0.023
rna interference GO:0016246 2 0.022
posttranscriptional regulation of gene expression GO:0010608 155 0.022
telencephalon development GO:0021537 186 0.022
ribonucleoside monophosphate metabolic process GO:0009161 80 0.022
gonad development GO:0008406 141 0.022
regulation of protein localization to nucleus GO:1900180 60 0.022
response to nutrient levels GO:0031667 109 0.022
Human
positive regulation of proteolysis GO:0045862 85 0.021
regulation of transcription factor import into nucleus GO:0042990 24 0.021
sensory perception GO:0007600 245 0.021
cognition GO:0050890 149 0.021
morphogenesis of embryonic epithelium GO:0016331 159 0.021
histone lysine methylation GO:0034968 50 0.021
response to organic cyclic compound GO:0014070 198 0.021
microtubule based process GO:0007017 236 0.020
regulation of antimicrobial humoral response GO:0002759 3 0.020
cellular response to lipid GO:0071396 145 0.020
lipid homeostasis GO:0055088 63 0.020
amine metabolic process GO:0009308 45 0.020
sterol metabolic process GO:0016125 58 0.020
negative regulation of intracellular protein transport GO:0090317 27 0.020
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.020
skin development GO:0043588 220 0.020
regulation of cellular ketone metabolic process GO:0010565 66 0.020
protein localization to membrane GO:0072657 108 0.020
protein n linked glycosylation GO:0006487 12 0.020
regulation of protein serine threonine kinase activity GO:0071900 157 0.019
anion transmembrane transport GO:0098656 71 0.019
oocyte construction GO:0007308 2 0.019
protein oligomerization GO:0051259 67 0.019
regulation of cell size GO:0008361 72 0.019
regulation of protein ubiquitination GO:0031396 52 0.019
protein methylation GO:0006479 81 0.019
regulation of vesicle mediated transport GO:0060627 139 0.019
organelle fission GO:0048285 170 0.019
positive regulation of histone modification GO:0031058 28 0.018
positive regulation of protein modification by small protein conjugation or removal GO:1903322 30 0.018
autophagy GO:0006914 45 0.018
Human
neural tube formation GO:0001841 108 0.018
protein import GO:0017038 101 0.018
positive regulation of programmed cell death GO:0043068 218 0.018
Human
regulation of cell activation GO:0050865 289 0.018
regulation of chromosome organization GO:0033044 83 0.018
stem cell proliferation GO:0072089 117 0.018
negative regulation of neuron death GO:1901215 98 0.018
cation transmembrane transport GO:0098655 266 0.018
acylglycerol homeostasis GO:0055090 16 0.018
atp metabolic process GO:0046034 75 0.018
regulation of hydrolase activity GO:0051336 246 0.018
negative regulation of protein transport GO:0051224 46 0.017
methylation GO:0032259 134 0.017
regulation of protein binding GO:0043393 60 0.017
negative regulation of intracellular transport GO:0032387 38 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.017
response to peptide GO:1901652 136 0.017
regulation of dna replication GO:0006275 17 0.017
neuron migration GO:0001764 122 0.016
regulation of neuron differentiation GO:0045664 281 0.016
cellular ion homeostasis GO:0006873 165 0.016
negative regulation of growth GO:0045926 99 0.016
protein homooligomerization GO:0051260 43 0.016
regulation of transmembrane transport GO:0034762 128 0.016
regulation of histone modification GO:0031056 56 0.016
response to organonitrogen compound GO:0010243 246 0.016
negative regulation of molecular function GO:0044092 258 0.015
carbohydrate metabolic process GO:0005975 230 0.015
alcohol metabolic process GO:0006066 116 0.015
meiotic cell cycle GO:0051321 122 0.015
germ cell development GO:0007281 185 0.015
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.015
positive regulation of peptidase activity GO:0010952 49 0.015
inorganic cation transmembrane transport GO:0098662 207 0.015
dna replication GO:0006260 52 0.015
histone ubiquitination GO:0016574 10 0.015
positive regulation of endopeptidase activity GO:0010950 43 0.015
synapsis GO:0007129 34 0.015
positive regulation of apoptotic signaling pathway GO:2001235 95 0.015
epidermis development GO:0008544 187 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.014
positive regulation of gtpase activity GO:0043547 85 0.014
negative regulation of phosphorylation GO:0042326 166 0.014
regulation of protein kinase activity GO:0045859 232 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
lipid localization GO:0010876 126 0.014
extrinsic apoptotic signaling pathway GO:0097191 126 0.014
fertilization GO:0009566 127 0.014
negative regulation of cellular component organization GO:0051129 194 0.014
metencephalon development GO:0022037 89 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
nerve development GO:0021675 67 0.014
locomotory behavior GO:0007626 195 0.014
regulation of nucleocytoplasmic transport GO:0046822 73 0.014
regulation of protein maturation GO:1903317 96 0.014
Human
regulation of cellular component size GO:0032535 121 0.014
organonitrogen compound biosynthetic process GO:1901566 192 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.014
skeletal system development GO:0001501 356 0.014
purine nucleoside monophosphate metabolic process GO:0009126 81 0.014
synaptic transmission GO:0007268 329 0.014
regulation of apoptotic signaling pathway GO:2001233 197 0.014
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.013
regulation of organelle organization GO:0033043 289 0.013
chromosome segregation GO:0007059 48 0.013
respiratory system development GO:0060541 190 0.013
rna processing GO:0006396 105 0.013
negative regulation of nucleocytoplasmic transport GO:0046823 23 0.013
regulation of cytoplasmic transport GO:1903649 112 0.013
cellular amine metabolic process GO:0044106 44 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
regulation of neuron death GO:1901214 134 0.013
nuclear export GO:0051168 34 0.013
lymphocyte differentiation GO:0030098 242 0.013
negative regulation of protein localization to nucleus GO:1900181 23 0.013
single organism nuclear import GO:1902593 95 0.013
glycoprotein metabolic process GO:0009100 116 0.013
regulation of ion transmembrane transport GO:0034765 119 0.013
respiratory tube development GO:0030323 167 0.013
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.013
regulation of binding GO:0051098 111 0.013
cranial nerve formation GO:0021603 4 0.013
innate immune response GO:0045087 157 0.013
response to extracellular stimulus GO:0009991 127 0.013
Human
regulation of cell projection organization GO:0031344 206 0.013
extracellular matrix organization GO:0030198 147 0.013
protein polyubiquitination GO:0000209 33 0.012
inorganic ion transmembrane transport GO:0098660 234 0.012
cholesterol transport GO:0030301 38 0.012
hematopoietic stem cell proliferation GO:0071425 13 0.012
cellular response to organic cyclic compound GO:0071407 87 0.012
regulation of nucleotide metabolic process GO:0006140 169 0.012
regulation of wnt signaling pathway GO:0030111 123 0.012
oocyte anterior posterior axis specification GO:0007314 2 0.012
tube formation GO:0035148 140 0.012
ras protein signal transduction GO:0007265 77 0.012
organic hydroxy compound metabolic process GO:1901615 203 0.012
single fertilization GO:0007338 82 0.012
carbohydrate biosynthetic process GO:0016051 74 0.012
positive regulation of kinase activity GO:0033674 155 0.012
epithelial tube morphogenesis GO:0060562 303 0.012
positive regulation of cellular amine metabolic process GO:0033240 5 0.012
regulation of cellular component biogenesis GO:0044087 181 0.012
Human
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.012
pole plasm assembly GO:0007315 2 0.012
axon target recognition GO:0007412 4 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.012
regulation of protein targeting GO:1903533 61 0.012
receptor mediated endocytosis GO:0006898 51 0.012
regulation of protein catabolic process GO:0042176 108 0.012
regulation of ras protein signal transduction GO:0046578 114 0.011
defense response to other organism GO:0098542 197 0.011
cellular response to extracellular stimulus GO:0031668 81 0.011
Human
negative regulation of cellular protein metabolic process GO:0032269 247 0.011
Human
bone development GO:0060348 120 0.011
reactive oxygen species biosynthetic process GO:1903409 8 0.011
positive regulation of cellular component biogenesis GO:0044089 94 0.011
Human
spermatid development GO:0007286 108 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.011
gtp metabolic process GO:0046039 144 0.011
regulation of leukocyte differentiation GO:1902105 159 0.011
regulation of cytoskeleton organization GO:0051493 122 0.011
positive regulation of protein ubiquitination GO:0031398 27 0.011
antimicrobial peptide biosynthetic process GO:0002777 2 0.011
positive regulation of transferase activity GO:0051347 167 0.011
positive regulation of chromatin modification GO:1903310 28 0.011
positive regulation of protein kinase activity GO:0045860 144 0.011
aggresome assembly GO:0070842 2 0.011
response to lipopolysaccharide GO:0032496 128 0.011
cranial nerve development GO:0021545 41 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.011
spermatid differentiation GO:0048515 115 0.011
response to sterol GO:0036314 4 0.011
response to molecule of bacterial origin GO:0002237 143 0.011
transcription factor import into nucleus GO:0042991 26 0.011
multicellular organismal homeostasis GO:0048871 164 0.010
regulation of cellular amine metabolic process GO:0033238 20 0.010
establishment of protein localization to membrane GO:0090150 54 0.010
regulation of reactive oxygen species metabolic process GO:2000377 40 0.010
response to peptide hormone GO:0043434 127 0.010
canonical wnt signaling pathway GO:0060070 130 0.010
sodium ion transport GO:0006814 73 0.010
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.010
sensory system development GO:0048880 3 0.010
neuron death GO:0070997 154 0.010
positive regulation of nucleotide metabolic process GO:0045981 114 0.010
cholesterol metabolic process GO:0008203 56 0.010
regulation of autophagy GO:0010506 30 0.010
peptidyl asparagine modification GO:0018196 1 0.010
thermosensory behavior GO:0040040 1 0.010
cellular response to organonitrogen compound GO:0071417 145 0.010
defense response to bacterium GO:0042742 119 0.010
vesicle localization GO:0051648 86 0.010

Hdac6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.224
nervous system disease DOID:863 0 0.224
central nervous system disease DOID:331 0 0.170
neurodegenerative disease DOID:1289 0 0.066
motor neuron disease DOID:231 0 0.029
retinal disease DOID:5679 0 0.028
sensory system disease DOID:0050155 0 0.028
eye and adnexa disease DOID:1492 0 0.028
eye disease DOID:5614 0 0.028
physical disorder DOID:0080015 0 0.028
retinal degeneration DOID:8466 0 0.023
congenital nervous system abnormality DOID:2490 0 0.021
amyotrophic lateral sclerosis DOID:332 0 0.018
disease of metabolism DOID:0014667 0 0.015
inherited metabolic disorder DOID:655 0 0.015
retinitis pigmentosa DOID:10584 0 0.013
neuromuscular disease DOID:440 0 0.010
neuropathy DOID:870 0 0.010