Mus musculus

154 known processes

Hells

helicase, lymphoid specific

(Aliases: Lysh,PASG,LSH,E130115I21Rik,YFK8,AI323785)

Hells biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna methylation involved in gamete generation GO:0043046 15 0.997
hypermethylation of cpg island GO:0044027 3 0.973
dna hypermethylation GO:0044026 3 0.968
double strand break repair GO:0006302 48 0.944
dna metabolic process GO:0006259 303 0.939
dna repair GO:0006281 107 0.930
chorion development GO:0060717 7 0.849
meiosis i GO:0007127 60 0.810
cellular response to dna damage stimulus GO:0006974 207 0.779
dna replication GO:0006260 52 0.745
purine nucleoside triphosphate catabolic process GO:0009146 203 0.718
meiotic cell cycle GO:0051321 122 0.697
dna modification GO:0006304 50 0.693
meiotic cell cycle process GO:1903046 77 0.688
negative regulation of cell cycle process GO:0010948 69 0.676
heterocycle catabolic process GO:0046700 280 0.657
dna methylation GO:0006306 43 0.636
recombinational repair GO:0000725 21 0.630
negative regulation of cell cycle GO:0045786 123 0.611
double strand break repair via homologous recombination GO:0000724 21 0.611
cellular macromolecule catabolic process GO:0044265 206 0.555
cell cycle checkpoint GO:0000075 47 0.511
synapsis GO:0007129 34 0.487
organic cyclic compound catabolic process GO:1901361 295 0.451
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.429
purine ribonucleotide metabolic process GO:0009150 290 0.426
nucleoside phosphate metabolic process GO:0006753 338 0.425
regulation of cell cycle process GO:0010564 160 0.407
purine nucleotide metabolic process GO:0006163 302 0.405
ribonucleoside triphosphate catabolic process GO:0009203 199 0.398
dna geometric change GO:0032392 7 0.396
nucleoside metabolic process GO:0009116 246 0.394
negative regulation of cellular component organization GO:0051129 194 0.386
nucleoside triphosphate metabolic process GO:0009141 230 0.379
reciprocal dna recombination GO:0035825 16 0.377
aromatic compound catabolic process GO:0019439 286 0.368
negative regulation of cell cycle phase transition GO:1901988 48 0.363
glycosyl compound metabolic process GO:1901657 246 0.350
cellular nitrogen compound catabolic process GO:0044270 280 0.343
regulation of dna replication GO:0006275 17 0.339
chromosome organization involved in meiosis GO:0070192 39 0.332
ribonucleoside triphosphate metabolic process GO:0009199 220 0.323
ribose phosphate metabolic process GO:0019693 291 0.312
ribonucleoside metabolic process GO:0009119 245 0.310
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.304
gonad development GO:0008406 141 0.302
purine nucleoside catabolic process GO:0006152 205 0.301
mitotic cell cycle process GO:1903047 159 0.299
organonitrogen compound catabolic process GO:1901565 264 0.297
purine containing compound metabolic process GO:0072521 311 0.292
cellular response to organonitrogen compound GO:0071417 145 0.278
meiotic nuclear division GO:0007126 115 0.276
nucleobase containing small molecule metabolic process GO:0055086 352 0.276
regulation of cell cycle g2 m phase transition GO:1902749 10 0.273
glycosyl compound catabolic process GO:1901658 206 0.273
purine nucleoside triphosphate metabolic process GO:0009144 226 0.264
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.263
ribonucleotide metabolic process GO:0009259 291 0.263
purine nucleoside metabolic process GO:0042278 241 0.258
negative regulation of protein metabolic process GO:0051248 282 0.255
positive regulation of histone h3 k4 methylation GO:0051571 5 0.251
nucleoside monophosphate metabolic process GO:0009123 85 0.250
histone methylation GO:0016571 71 0.247
methylation GO:0032259 134 0.244
spermatogenesis GO:0007283 284 0.244
dna recombination GO:0006310 92 0.243
Yeast
regulation of chromosome organization GO:0033044 83 0.236
ribonucleotide catabolic process GO:0009261 208 0.236
negative regulation of nuclear division GO:0051784 19 0.221
purine ribonucleotide catabolic process GO:0009154 208 0.219
purine nucleotide catabolic process GO:0006195 211 0.219
carbohydrate derivative catabolic process GO:1901136 231 0.217
dna dependent dna replication GO:0006261 24 0.216
regulation of mitotic cell cycle phase transition GO:1901990 73 0.211
nucleoside catabolic process GO:0009164 206 0.209
dna alkylation GO:0006305 43 0.206
purine ribonucleoside metabolic process GO:0046128 241 0.206
organelle fission GO:0048285 170 0.202
nucleotide catabolic process GO:0009166 217 0.193
regulation of hydrolase activity GO:0051336 246 0.192
mitotic cell cycle GO:0000278 195 0.176
microtubule cytoskeleton organization GO:0000226 157 0.175
nucleoside triphosphate catabolic process GO:0009143 205 0.173
regulation of cell cycle GO:0051726 281 0.169
regulation of dna methylation GO:0044030 12 0.166
male gamete generation GO:0048232 285 0.165
mitotic g2 dna damage checkpoint GO:0007095 8 0.154
regulation of cell cycle phase transition GO:1901987 77 0.153
meiotic chromosome segregation GO:0045132 19 0.149
dna methylation involved in embryo development GO:0043045 6 0.146
nucleotide metabolic process GO:0009117 332 0.143
macromolecule methylation GO:0043414 120 0.143
ribonucleoside catabolic process GO:0042454 206 0.142
histone h3 k9 methylation GO:0051567 17 0.139
protein methylation GO:0006479 81 0.139
regulation of histone h3 k4 methylation GO:0051569 12 0.138
female meiosis chromosome segregation GO:0016321 1 0.138
positive regulation of histone methylation GO:0031062 16 0.134
nucleoside phosphate catabolic process GO:1901292 222 0.133
regulation of cell division GO:0051302 76 0.132
dosage compensation by inactivation of x chromosome GO:0009048 7 0.130
negative regulation of histone methylation GO:0031061 10 0.126
negative regulation of histone h3 k9 methylation GO:0051573 4 0.125
regulation of gene expression by genetic imprinting GO:0006349 15 0.125
response to organonitrogen compound GO:0010243 246 0.123
negative regulation of mitotic cell cycle GO:0045930 58 0.122
regulation of histone h3 k9 methylation GO:0051570 8 0.119
chromatin organization GO:0006325 206 0.118
regulation of organelle organization GO:0033043 289 0.118
dna endoreduplication GO:0042023 4 0.117
histone lysine methylation GO:0034968 50 0.116
development of primary sexual characteristics GO:0045137 143 0.116
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.116
genetic imprinting GO:0071514 27 0.115
chromatin modification GO:0016568 187 0.114
dna catabolic process GO:0006308 19 0.112
protein modification by small protein conjugation or removal GO:0070647 207 0.111
double strand break repair via nonhomologous end joining GO:0006303 10 0.109
histone acetylation GO:0016573 41 0.108
changes to dna methylation involved in embryo development GO:1901538 6 0.107
nuclear division GO:0000280 158 0.107
negative regulation of gene expression epigenetic GO:0045814 15 0.106
negative regulation of dna replication GO:0008156 4 0.104
response to radiation GO:0009314 165 0.104
dna methylation on cytosine GO:0032776 5 0.097
dna catabolic process exonucleolytic GO:0000738 3 0.096
positive regulation of apoptotic process GO:0043065 217 0.095
macromolecule catabolic process GO:0009057 281 0.092
organophosphate catabolic process GO:0046434 232 0.091
purine nucleoside monophosphate metabolic process GO:0009126 81 0.091
regulation of chromatin modification GO:1903308 57 0.090
organelle assembly GO:0070925 177 0.090
intrinsic apoptotic signaling pathway GO:0097193 132 0.089
genitalia development GO:0048806 37 0.087
female meiotic division GO:0007143 21 0.083
maintenance of location GO:0051235 89 0.082
purine nucleoside monophosphate catabolic process GO:0009128 58 0.082
reciprocal meiotic recombination GO:0007131 16 0.081
purine ribonucleoside catabolic process GO:0046130 205 0.080
camera type eye development GO:0043010 266 0.080
ribonucleoside monophosphate metabolic process GO:0009161 80 0.080
apoptotic signaling pathway GO:0097190 306 0.078
regulation of meiosis i GO:0060631 7 0.077
dna catabolic process endonucleolytic GO:0000737 15 0.076
microtubule based process GO:0007017 236 0.076
histone threonine phosphorylation GO:0035405 1 0.072
gene silencing GO:0016458 38 0.071
response to organic cyclic compound GO:0014070 198 0.070
chorionic trophoblast cell differentiation GO:0060718 5 0.068
protein modification by small protein conjugation GO:0032446 187 0.067
positive regulation of chromatin modification GO:1903310 28 0.067
atp metabolic process GO:0046034 75 0.066
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.064
translesion synthesis GO:0019985 1 0.064
heterochromatin organization GO:0070828 4 0.063
protein alkylation GO:0008213 81 0.062
cellular ketone metabolic process GO:0042180 84 0.060
retina development in camera type eye GO:0060041 119 0.060
microtubule organizing center organization GO:0031023 28 0.058
cellular response to acid chemical GO:0071229 68 0.058
endocytosis GO:0006897 168 0.057
regulation of cellular amino acid metabolic process GO:0006521 5 0.057
regulation of mitotic cell cycle GO:0007346 126 0.056
ubiquitin dependent protein catabolic process GO:0006511 129 0.056
mitotic recombination GO:0006312 3 0.056
Yeast
cellular protein catabolic process GO:0044257 155 0.056
cellular response to organic cyclic compound GO:0071407 87 0.055
histone h3 k4 methylation GO:0051568 23 0.053
regulation of histone modification GO:0031056 56 0.053
response to ionizing radiation GO:0010212 42 0.052
regulation of nucleotide metabolic process GO:0006140 169 0.052
negative regulation of organelle organization GO:0010639 90 0.052
placenta development GO:0001890 140 0.052
ribonucleoside monophosphate catabolic process GO:0009158 57 0.051
chromatin silencing GO:0006342 15 0.051
protein catabolic process GO:0030163 221 0.050
g2 dna damage checkpoint GO:0031572 8 0.048
membrane organization GO:0061024 245 0.047
nucleoside monophosphate catabolic process GO:0009125 59 0.046
regulation of cellular catabolic process GO:0031329 242 0.046
purine containing compound catabolic process GO:0072523 213 0.046
regulation of dna dependent dna replication GO:0090329 8 0.045
meiotic cell cycle checkpoint GO:0033313 2 0.045
negative regulation of chromosome organization GO:2001251 30 0.045
cellular amine metabolic process GO:0044106 44 0.044
germ cell development GO:0007281 185 0.044
cell division GO:0051301 120 0.044
regulation of histone methylation GO:0031060 30 0.044
nuclear dna replication GO:0033260 3 0.042
positive regulation of cell cycle phase transition GO:1901989 17 0.042
regulation of mitosis GO:0007088 29 0.041
male meiosis GO:0007140 37 0.041
regulation of centriole replication GO:0046599 1 0.040
non recombinational repair GO:0000726 10 0.040
dna integrity checkpoint GO:0031570 28 0.040
spindle assembly involved in female meiosis GO:0007056 3 0.039
atp catabolic process GO:0006200 55 0.039
response to amino acid GO:0043200 37 0.039
cellular amino acid metabolic process GO:0006520 103 0.039
negative regulation of cellular protein metabolic process GO:0032269 247 0.038
digestive system development GO:0055123 200 0.038
positive regulation of programmed cell death GO:0043068 218 0.038
positive regulation of hydrolase activity GO:0051345 148 0.038
regulation of nucleoside metabolic process GO:0009118 130 0.037
receptor mediated endocytosis GO:0006898 51 0.036
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.034
mitotic cell cycle checkpoint GO:0007093 31 0.034
regulation of cellular amine metabolic process GO:0033238 20 0.033
dna damage checkpoint GO:0000077 26 0.033
dna duplex unwinding GO:0032508 7 0.032
regulation of dna recombination GO:0000018 34 0.032
covalent chromatin modification GO:0016569 163 0.031
regulation of cellular ketone metabolic process GO:0010565 66 0.031
meiotic dna double strand break formation GO:0042138 3 0.031
cellular response to amino acid stimulus GO:0071230 29 0.031
response to acid chemical GO:0001101 111 0.031
regulation of purine nucleotide metabolic process GO:1900542 169 0.030
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.029
positive regulation of cell development GO:0010720 237 0.029
response to light stimulus GO:0009416 135 0.028
regulation of transcription by chromatin organization GO:0034401 0 0.028
chromosome segregation GO:0007059 48 0.028
neural retina development GO:0003407 41 0.028
regulation of transferase activity GO:0051338 263 0.027
dna ligation GO:0006266 3 0.027
neuron migration GO:0001764 122 0.026
positive regulation of nucleotide metabolic process GO:0045981 114 0.026
eye photoreceptor cell differentiation GO:0001754 41 0.026
negative regulation of cell division GO:0051782 24 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.025
regulation of chromatin organization GO:1902275 57 0.025
engulfment of apoptotic cell GO:0043652 3 0.025
negative regulation of meiotic cell cycle phase transition GO:1901994 3 0.024
nucleocytoplasmic transport GO:0006913 139 0.024
intra s dna damage checkpoint GO:0031573 4 0.024
dna unwinding involved in dna replication GO:0006268 5 0.023
female gamete generation GO:0007292 74 0.023
positive regulation of lymphocyte activation GO:0051251 140 0.022
amine metabolic process GO:0009308 45 0.022
organophosphate biosynthetic process GO:0090407 122 0.022
multicellular organism growth GO:0035264 161 0.022
mitochondrion organization GO:0007005 134 0.021
response to alkaloid GO:0043279 34 0.021
positive regulation of gtp catabolic process GO:0033126 85 0.021
protein import into nucleus GO:0006606 95 0.021
peptidyl amino acid modification GO:0018193 336 0.021
dna biosynthetic process GO:0071897 22 0.021
positive regulation of cell cycle process GO:0090068 61 0.021
mitochondrial genome maintenance GO:0000002 15 0.020
positive regulation of cell death GO:0010942 224 0.020
cellular response to abiotic stimulus GO:0071214 56 0.020
regulation of purine nucleotide catabolic process GO:0033121 122 0.020
protein processing GO:0016485 163 0.019
regulation of cell activation GO:0050865 289 0.019
protein maturation GO:0051604 176 0.019
regulation of nucleotide catabolic process GO:0030811 122 0.019
meiotic chromosome condensation GO:0010032 3 0.019
negative regulation of meiotic cell cycle GO:0051447 14 0.019
positive regulation of cellular catabolic process GO:0031331 148 0.018
protein oligomerization GO:0051259 67 0.018
establishment of organelle localization GO:0051656 122 0.018
rna dependent dna replication GO:0006278 3 0.018
response to purine containing compound GO:0014074 28 0.018
regulation of protein localization GO:0032880 231 0.018
spindle organization GO:0007051 28 0.017
sensory organ morphogenesis GO:0090596 242 0.017
oxidation reduction process GO:0055114 342 0.017
dna replication initiation GO:0006270 5 0.017
regulation of nuclear cell cycle dna replication GO:0033262 2 0.017
peptidyl lysine modification GO:0018205 77 0.017
membrane invagination GO:0010324 17 0.017
spermatid differentiation GO:0048515 115 0.017
retina morphogenesis in camera type eye GO:0060042 45 0.017
positive regulation of histone h3 k9 methylation GO:0051574 4 0.016
protein ubiquitination GO:0016567 171 0.016
cell cycle g1 s phase transition GO:0044843 57 0.016
ras protein signal transduction GO:0007265 77 0.016
regulation of lymphocyte activation GO:0051249 240 0.016
cell fate commitment GO:0045165 210 0.016
protein acylation GO:0043543 64 0.016
positive regulation of cellular amine metabolic process GO:0033240 5 0.016
response to caffeine GO:0031000 6 0.015
positive regulation of protein modification process GO:0031401 299 0.015
regulation of asymmetric cell division GO:0009786 4 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
cellular protein complex assembly GO:0043623 116 0.015
regulation of apoptotic signaling pathway GO:2001233 197 0.015
forebrain development GO:0030900 302 0.015
histone h4 k20 trimethylation GO:0034773 2 0.015
negative regulation of protein maturation GO:1903318 79 0.015
intracellular protein transport GO:0006886 204 0.015
anatomical structure homeostasis GO:0060249 145 0.015
cell type specific apoptotic process GO:0097285 268 0.015
response to inorganic substance GO:0010035 96 0.015
rna interference GO:0016246 2 0.015
regulation of neuron differentiation GO:0045664 281 0.015
interspecies interaction between organisms GO:0044419 83 0.015
regulation of cellular response to stress GO:0080135 159 0.015
guanosine containing compound catabolic process GO:1901069 144 0.015
exocrine system development GO:0035272 45 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
protein localization to nucleus GO:0034504 121 0.014
mitochondrial dna replication GO:0006264 7 0.014
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.014
establishment of protein localization to organelle GO:0072594 118 0.014
dna conformation change GO:0071103 37 0.014
nucleoside phosphate biosynthetic process GO:1901293 79 0.014
regulation of rho protein signal transduction GO:0035023 71 0.014
mitotic nuclear division GO:0007067 48 0.014
cellularization GO:0007349 1 0.014
synaptonemal complex assembly GO:0007130 13 0.014
rho protein signal transduction GO:0007266 32 0.014
positive regulation of histone modification GO:0031058 28 0.014
regulation of intracellular transport GO:0032386 159 0.014
positive regulation of cellular component biogenesis GO:0044089 94 0.014
actin mediated cell contraction GO:0070252 15 0.014
sister chromatid segregation GO:0000819 20 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.013
modification dependent protein catabolic process GO:0019941 133 0.013
cellular response to cytokine stimulus GO:0071345 189 0.013
gene silencing by rna GO:0031047 19 0.013
actin cytoskeleton organization GO:0030036 220 0.013
negative regulation of mitosis GO:0045839 10 0.013
cellular response to oxidative stress GO:0034599 76 0.013
regulation of cellular component biogenesis GO:0044087 181 0.013
peptidyl lysine acetylation GO:0018394 45 0.012
striated muscle myosin thick filament assembly GO:0071688 1 0.012
guanosine containing compound metabolic process GO:1901068 144 0.012
negative regulation of hydrolase activity GO:0051346 71 0.012
single organism nuclear import GO:1902593 95 0.012
regulation of peptidase activity GO:0052547 96 0.012
response to steroid hormone GO:0048545 56 0.012
chromatin mediated maintenance of transcription GO:0048096 2 0.012
mitotic sister chromatid cohesion GO:0007064 1 0.012
positive regulation of nervous system development GO:0051962 221 0.012
posttranscriptional gene silencing GO:0016441 10 0.012
female meiosis i GO:0007144 7 0.012
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.012
cellular response to ionizing radiation GO:0071479 11 0.012
regulation of attachment of spindle microtubules to kinetochore GO:0051988 3 0.012
regulation of cell projection organization GO:0031344 206 0.012
cellular response to external stimulus GO:0071496 88 0.012
cellular response to hormone stimulus GO:0032870 150 0.011
regulation of neural precursor cell proliferation GO:2000177 70 0.011
regulation of microtubule based process GO:0032886 52 0.011
spindle assembly involved in meiosis GO:0090306 4 0.011
regulation of neuron projection development GO:0010975 169 0.011
chromatin assembly or disassembly GO:0006333 16 0.011
negative regulation of proteolysis GO:0045861 74 0.011
wnt signaling pathway GO:0016055 188 0.011
base excision repair GO:0006284 9 0.011
negative regulation of neuron death GO:1901215 98 0.011
protein targeting GO:0006605 143 0.011
negative regulation of dna dependent dna replication GO:2000104 1 0.011
neural precursor cell proliferation GO:0061351 121 0.011
response to metal ion GO:0010038 47 0.011
regulation of canonical wnt signaling pathway GO:0060828 82 0.011
protein complex localization GO:0031503 19 0.011
regulation of actin filament based process GO:0032970 99 0.011
positive regulation of growth GO:0045927 104 0.011
positive regulation of cell cycle GO:0045787 92 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.011
pancreas development GO:0031016 57 0.011
production of molecular mediator of immune response GO:0002440 103 0.011
actomyosin structure organization GO:0031032 56 0.011
axonogenesis GO:0007409 274 0.011
response to oxidative stress GO:0006979 123 0.011
regulation of protein maturation GO:1903317 96 0.010
positive regulation of nucleoside metabolic process GO:0045979 91 0.010
cell maturation GO:0048469 127 0.010
nuclear transport GO:0051169 139 0.010
regulation of cytoplasmic transport GO:1903649 112 0.010
regulation of vesicle mediated transport GO:0060627 139 0.010
regulation of ras protein signal transduction GO:0046578 114 0.010
inner cell mass cell proliferation GO:0001833 15 0.010
leukocyte differentiation GO:0002521 342 0.010
negative regulation of sister chromatid segregation GO:0033046 7 0.010
blastocyst development GO:0001824 80 0.010
proteasomal protein catabolic process GO:0010498 98 0.010
intracellular mrna localization GO:0008298 4 0.010
response to hypoxia GO:0001666 58 0.010
nucleus organization GO:0006997 45 0.010
cytoplasmic transport GO:0016482 234 0.010
lipid localization GO:0010876 126 0.010

Hells disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.024
thoracic cancer DOID:5093 0 0.024
cancer DOID:162 0 0.024
organ system cancer DOID:0050686 0 0.024
physical disorder DOID:0080015 0 0.015
breast cancer DOID:1612 0 0.013