Mus musculus

494 known processes

Hif1a

hypoxia inducible factor 1, alpha subunit

(Aliases: AA959795,bHLHe78,MOP1,HIF1alpha)

Hif1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of thymocyte apoptotic process GO:0070243 14 0.993
lymphocyte homeostasis GO:0002260 64 0.991
embryonic placenta development GO:0001892 98 0.991
mesonephric tubule development GO:0072164 94 0.984
Mouse
gas homeostasis GO:0033483 3 0.983
cell type specific apoptotic process GO:0097285 268 0.982
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.982
response to light stimulus GO:0009416 135 0.976
wound healing GO:0042060 157 0.971
neuron apoptotic process GO:0051402 142 0.966
cellular response to oxidative stress GO:0034599 76 0.960
pole plasm assembly GO:0007315 2 0.953
dendrite development GO:0016358 115 0.950
purine nucleotide metabolic process GO:0006163 302 0.949
blood vessel morphogenesis GO:0048514 285 0.949
urogenital system development GO:0001655 261 0.944
Mouse
muscle tissue development GO:0060537 308 0.941
regulation of cellular component biogenesis GO:0044087 181 0.938
regulation of neuron apoptotic process GO:0043523 122 0.938
dna metabolic process GO:0006259 303 0.937
lymphocyte apoptotic process GO:0070227 54 0.936
lymphocyte proliferation GO:0046651 164 0.934
regulation of protein complex assembly GO:0043254 83 0.932
peptidyl amino acid modification GO:0018193 336 0.929
glial cell apoptotic process GO:0034349 3 0.926
cell adhesion mediated by integrin GO:0033627 18 0.926
germ cell development GO:0007281 185 0.924
Fly
regulation of membrane potential GO:0042391 192 0.922
thymocyte apoptotic process GO:0070242 19 0.922
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.918
protein catabolic process GO:0030163 221 0.915
positive regulation of cell development GO:0010720 237 0.905
cellular response to external stimulus GO:0071496 88 0.902
Rat Worm
activation of mapk activity involved in innate immune response GO:0035419 2 0.902
amine metabolic process GO:0009308 45 0.897
t cell activation GO:0042110 289 0.893
epidermis development GO:0008544 187 0.888
negative regulation of t cell proliferation GO:0042130 38 0.880
heart trabecula formation GO:0060347 14 0.878
regulation of kinase activity GO:0043549 249 0.874
regulation of nucleotide metabolic process GO:0006140 169 0.873
tissue migration GO:0090130 68 0.871
ameboidal type cell migration GO:0001667 128 0.863
oocyte axis specification GO:0007309 2 0.862
cation transport GO:0006812 399 0.856
oocyte construction GO:0007308 2 0.856
angiogenesis GO:0001525 201 0.855
cellular ketone metabolic process GO:0042180 84 0.855
4 hydroxyproline metabolic process GO:0019471 5 0.852
cell fate commitment GO:0045165 210 0.844
Mouse
actin filament organization GO:0007015 113 0.842
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.840
negative regulation of growth GO:0045926 99 0.838
epithelial tube morphogenesis GO:0060562 303 0.836
neuron death GO:0070997 154 0.835
erythrocyte differentiation GO:0030218 88 0.832
positive regulation of protein catabolic process GO:0045732 60 0.829
autophagy GO:0006914 45 0.824
Fly
organonitrogen compound catabolic process GO:1901565 264 0.823
phenol containing compound metabolic process GO:0018958 60 0.821
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 95 0.811
i kappab kinase nf kappab signaling GO:0007249 85 0.811
positive regulation of apoptotic process GO:0043065 217 0.805
Rat
carbon catabolite activation of transcription GO:0045991 4 0.801
nucleoside phosphate metabolic process GO:0006753 338 0.798
cellular amino acid metabolic process GO:0006520 103 0.796
digestive tract development GO:0048565 190 0.793
nuclear transport GO:0051169 139 0.784
regulation of wound healing GO:0061041 40 0.782
regulation of anoikis GO:2000209 2 0.781
cytokine production GO:0001816 319 0.779
Human
myelination in peripheral nervous system GO:0022011 19 0.778
gliogenesis GO:0042063 141 0.777
cellular response to extracellular stimulus GO:0031668 81 0.776
Worm
axon guidance GO:0007411 141 0.774
negative regulation of epithelial cell proliferation GO:0050680 64 0.774
regulation of purine nucleotide metabolic process GO:1900542 169 0.770
homeostasis of number of cells GO:0048872 210 0.767
substrate dependent cell migration cell extension GO:0006930 4 0.764
negative regulation of cell proliferation GO:0008285 296 0.762
cellular chemical homeostasis GO:0055082 215 0.761
lactation GO:0007595 25 0.759
regulation of cell cycle GO:0051726 281 0.753
Fly
regulation of t cell apoptotic process GO:0070232 28 0.749
purine nucleotide biosynthetic process GO:0006164 65 0.746
locomotory behavior GO:0007626 195 0.746
Mouse
response to starvation GO:0042594 65 0.742
Worm
oogenesis GO:0048477 56 0.742
Fly
chemotaxis GO:0006935 247 0.738
protein localization to organelle GO:0033365 185 0.736
cellular response to hormone stimulus GO:0032870 150 0.735
Rat Fly
regulation of lymphocyte proliferation GO:0050670 117 0.735
regulation of cellular amine metabolic process GO:0033238 20 0.733
sprouting angiogenesis GO:0002040 26 0.733
striated muscle tissue development GO:0014706 293 0.732
branching morphogenesis of an epithelial tube GO:0048754 159 0.731
formation of radial glial scaffolds GO:0021943 4 0.730
metal ion homeostasis GO:0055065 189 0.729
actin polymerization or depolymerization GO:0008154 54 0.728
membrane invagination GO:0010324 17 0.727
hair follicle development GO:0001942 85 0.723
immune effector process GO:0002252 321 0.723
neuronal action potential GO:0019228 54 0.722
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.721
ribonucleotide metabolic process GO:0009259 291 0.721
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.718
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.717
regulation of ion transport GO:0043269 215 0.717
regulation of actin cytoskeleton organization GO:0032956 84 0.709
macromolecule catabolic process GO:0009057 281 0.708
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.706
response to purine containing compound GO:0014074 28 0.703
Rat
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.702
response to endoplasmic reticulum stress GO:0034976 53 0.694
epithelial cell proliferation GO:0050673 174 0.691
respiratory tube development GO:0030323 167 0.691
Mouse
t cell apoptotic process GO:0070231 39 0.691
regulation of canonical wnt signaling pathway GO:0060828 82 0.690
stem cell development GO:0048864 219 0.690
carbon catabolite regulation of transcription GO:0045990 4 0.688
regulation of hydrolase activity GO:0051336 246 0.683
cellular response to dna damage stimulus GO:0006974 207 0.682
Fly
response to peptide GO:1901652 136 0.679
Rat Fly
engulfment of apoptotic cell GO:0043652 3 0.678
regulation of cellular ketone metabolic process GO:0010565 66 0.677
response to peptide hormone GO:0043434 127 0.676
Rat Fly
purine ribonucleotide catabolic process GO:0009154 208 0.674
regionalization GO:0003002 337 0.674
cellular response to growth factor stimulus GO:0071363 197 0.673
alpha amino acid metabolic process GO:1901605 59 0.671
photoreceptor cell morphogenesis GO:0008594 3 0.671
generation of precursor metabolites and energy GO:0006091 103 0.667
cell adhesion GO:0007155 329 0.666
microtubule cytoskeleton organization GO:0000226 157 0.661
modification dependent protein catabolic process GO:0019941 133 0.661
leukocyte homeostasis GO:0001776 79 0.656
purine containing compound biosynthetic process GO:0072522 70 0.656
regulation of cytoskeleton organization GO:0051493 122 0.654
regulation of cell adhesion mediated by integrin GO:0033628 13 0.653
muscle tissue morphogenesis GO:0060415 53 0.649
response to nutrient levels GO:0031667 109 0.647
Worm
positive regulation of protein modification process GO:0031401 299 0.646
nucleoside phosphate biosynthetic process GO:1901293 79 0.644
nucleotide biosynthetic process GO:0009165 78 0.638
regulation of leukocyte apoptotic process GO:2000106 56 0.637
extrinsic apoptotic signaling pathway GO:0097191 126 0.634
negative regulation of leukocyte proliferation GO:0070664 46 0.634
cellular response to insulin stimulus GO:0032869 78 0.631
Rat Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.628
single organismal cell cell adhesion GO:0016337 131 0.628
epithelium migration GO:0090132 63 0.627
regulation of myeloid cell differentiation GO:0045637 96 0.626
ribonucleotide catabolic process GO:0009261 208 0.622
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.618
skin development GO:0043588 220 0.618
purine ribonucleotide metabolic process GO:0009150 290 0.615
negative regulation of bmp signaling pathway GO:0030514 35 0.614
positive regulation of cell adhesion GO:0045785 80 0.614
b cell differentiation GO:0030183 78 0.613
leukocyte apoptotic process GO:0071887 71 0.612
nitrogen compound transport GO:0071705 271 0.610
regulation of proteolysis GO:0030162 164 0.610
cell growth GO:0016049 130 0.606
Fly
cyclic nucleotide metabolic process GO:0009187 59 0.603
positive regulation of dendrite development GO:1900006 21 0.594
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.590
ion transmembrane transport GO:0034220 361 0.588
regulation of protein localization GO:0032880 231 0.588
positive regulation of response to wounding GO:1903036 66 0.583
purine nucleoside metabolic process GO:0042278 241 0.582
rac protein signal transduction GO:0016601 13 0.579
regulation of protein kinase activity GO:0045859 232 0.578
keratinocyte differentiation GO:0030216 48 0.576
cellular protein catabolic process GO:0044257 155 0.573
purine nucleoside catabolic process GO:0006152 205 0.569
respiratory system development GO:0060541 190 0.568
Mouse Fly
regulation of autophagy GO:0010506 30 0.556
Fly
positive regulation of protein complex assembly GO:0031334 45 0.554
tissue remodeling GO:0048771 102 0.549
heart contraction GO:0060047 93 0.546
Mouse
female gamete generation GO:0007292 74 0.545
Fly
regulation of protein catabolic process GO:0042176 108 0.544
response to insulin GO:0032868 100 0.544
Rat Fly
heart trabecula morphogenesis GO:0061384 26 0.541
cellular response to organic cyclic compound GO:0071407 87 0.538
Rat
negative regulation of necrotic cell death GO:0060547 11 0.536
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.534
regulation of protein targeting GO:1903533 61 0.530
regulation of secretion GO:0051046 274 0.527
pigment metabolic process GO:0042440 32 0.519
response to radiation GO:0009314 165 0.518
mesonephric epithelium development GO:0072163 94 0.517
Mouse
regulation of cell adhesion GO:0030155 154 0.517
monosaccharide metabolic process GO:0005996 106 0.517
cardiac endothelial cell differentiation GO:0003348 4 0.516
nucleobase containing small molecule metabolic process GO:0055086 352 0.514
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.511
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.508
regulation of lymphocyte apoptotic process GO:0070228 41 0.506
ribonucleotide biosynthetic process GO:0009260 59 0.506
negative regulation of tor signaling GO:0032007 13 0.504
cytoplasmic transport GO:0016482 234 0.504
regulation of dna templated transcription in response to stress GO:0043620 9 0.504
response to organonitrogen compound GO:0010243 246 0.503
Rat Fly
developmental maturation GO:0021700 193 0.502
cardiac muscle tissue development GO:0048738 130 0.502
glycosyl compound metabolic process GO:1901657 246 0.501
purine ribonucleotide biosynthetic process GO:0009152 59 0.501
regulation of neuron death GO:1901214 134 0.498
lymphocyte differentiation GO:0030098 242 0.496
multicellular organismal signaling GO:0035637 91 0.495
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.495
negative regulation of lymphocyte proliferation GO:0050672 45 0.495
cellular response to inorganic substance GO:0071241 37 0.488
Rat
cellular response to glucocorticoid stimulus GO:0071385 13 0.486
nucleocytoplasmic transport GO:0006913 139 0.481
molting cycle GO:0042303 90 0.479
action potential GO:0001508 78 0.476
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.472
negative regulation of phosphorylation GO:0042326 166 0.472
epithelial to mesenchymal transition GO:0001837 47 0.470
apoptotic signaling pathway GO:0097190 306 0.469
Human
regulation of cell growth GO:0001558 91 0.466
Fly
ventricular septum development GO:0003281 42 0.465
dendritic spine development GO:0060996 30 0.464
cell chemotaxis GO:0060326 81 0.463
multicellular organismal aging GO:0010259 24 0.462
Worm
positive regulation of transcription by galactose GO:0000411 1 0.462
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.461
response to oxygen levels GO:0070482 62 0.458
regulation of blood circulation GO:1903522 93 0.457
Mouse Rat
regulation of hormone secretion GO:0046883 88 0.455
response to hypoxia GO:0001666 58 0.455
organonitrogen compound biosynthetic process GO:1901566 192 0.454
extracellular matrix organization GO:0030198 147 0.453
hair cycle GO:0042633 90 0.452
cell substrate adhesion GO:0031589 130 0.451
schwann cell development GO:0014044 22 0.451
regulation of secretion by cell GO:1903530 249 0.449
cellular modified amino acid metabolic process GO:0006575 63 0.447
regulation of cell activation GO:0050865 289 0.446
cation homeostasis GO:0055080 212 0.442
cytokine mediated signaling pathway GO:0019221 115 0.440
camp biosynthetic process GO:0006171 31 0.440
ureteric bud development GO:0001657 94 0.439
Mouse
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.439
cardiac muscle tissue morphogenesis GO:0055008 44 0.436
negative regulation of protein phosphorylation GO:0001933 126 0.434
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.433
membrane organization GO:0061024 245 0.432
positive regulation of nervous system development GO:0051962 221 0.432
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.432
fibronectin dependent thymocyte migration GO:0072681 1 0.432
labyrinthine layer development GO:0060711 49 0.432
proteasomal protein catabolic process GO:0010498 98 0.429
regulation of atp metabolic process GO:1903578 17 0.427
hexose biosynthetic process GO:0019319 39 0.426
carbohydrate derivative biosynthetic process GO:1901137 183 0.424
rhythmic process GO:0048511 174 0.423
macrophage differentiation GO:0030225 20 0.423
positive regulation of cell death GO:0010942 224 0.422
Rat
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.419
regulation of actin filament length GO:0030832 45 0.418
nucleoside monophosphate metabolic process GO:0009123 85 0.407
neuron projection guidance GO:0097485 141 0.405
mesenchyme development GO:0060485 152 0.402
regulation of wnt signaling pathway GO:0030111 123 0.402
carbohydrate homeostasis GO:0033500 128 0.401
cardiac epithelial to mesenchymal transition GO:0060317 18 0.399
cellular carbohydrate metabolic process GO:0044262 119 0.399
regulation of cellular response to stress GO:0080135 159 0.398
Human Rat
negative regulation of apoptotic signaling pathway GO:2001234 104 0.396
Human
positive regulation of cellular component biogenesis GO:0044089 94 0.396
regulation of homeostatic process GO:0032844 182 0.394
regulation of chemotaxis GO:0050920 53 0.394
cardiac muscle tissue growth GO:0055017 37 0.392
modification dependent macromolecule catabolic process GO:0043632 133 0.390
blood circulation GO:0008015 195 0.390
Mouse Rat
sensory perception GO:0007600 245 0.390
Mouse
ear development GO:0043583 200 0.390
ventricular septum morphogenesis GO:0060412 27 0.388
regulation of neuroblast proliferation GO:1902692 27 0.386
regulation of epidermal growth factor activated receptor activity GO:0007176 7 0.386
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.384
positive regulation of cell growth GO:0030307 33 0.384
regulation of response to wounding GO:1903034 189 0.382
visual learning GO:0008542 44 0.380
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 56 0.378
cell maturation GO:0048469 127 0.373
regulation of t cell proliferation GO:0042129 92 0.372
cell growth involved in cardiac muscle cell development GO:0061049 3 0.372
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.372
nucleotide catabolic process GO:0009166 217 0.369
digestive tract morphogenesis GO:0048546 147 0.368
learning GO:0007612 98 0.367
spermatogenesis GO:0007283 284 0.367
segmentation GO:0035282 93 0.366
regulation of cellular amino acid metabolic process GO:0006521 5 0.366
b cell proliferation GO:0042100 53 0.365
negative regulation of intracellular signal transduction GO:1902532 167 0.365
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.364
carbohydrate metabolic process GO:0005975 230 0.364
cognition GO:0050890 149 0.364
cation transmembrane transport GO:0098655 266 0.362
negative regulation of lymphocyte activation GO:0051250 91 0.362
canonical wnt signaling pathway GO:0060070 130 0.360
negative regulation of anoikis GO:2000811 2 0.360
cellular response to organonitrogen compound GO:0071417 145 0.360
Rat Fly
ensheathment of neurons GO:0007272 76 0.357
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.356
negative regulation of protein depolymerization GO:1901880 21 0.355
circadian rhythm GO:0007623 114 0.354
divalent inorganic cation transport GO:0072511 178 0.353
negative regulation of glial cell proliferation GO:0060253 4 0.351
reactive oxygen species metabolic process GO:0072593 84 0.346
anatomical structure homeostasis GO:0060249 145 0.344
glucose homeostasis GO:0042593 128 0.344
regulation of leukocyte differentiation GO:1902105 159 0.340
actin filament polymerization GO:0030041 44 0.340
positive regulation of mapk cascade GO:0043410 170 0.340
positive regulation of protein kinase activity GO:0045860 144 0.339
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 17 0.339
mitochondrion organization GO:0007005 134 0.335
Mouse
ribose phosphate metabolic process GO:0019693 291 0.335
cellular divalent inorganic cation homeostasis GO:0072503 127 0.334
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.334
regulation of protein serine threonine kinase activity GO:0071900 157 0.334
negative regulation of cell cycle GO:0045786 123 0.333
oocyte anterior posterior axis specification GO:0007314 2 0.332
regulation of cellular catabolic process GO:0031329 242 0.332
endothelial cell differentiation GO:0045446 41 0.331
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.331
myelination GO:0042552 74 0.331
nucleoside phosphate catabolic process GO:1901292 222 0.330
transmembrane transport GO:0055085 412 0.327
regulation of bmp signaling pathway GO:0030510 60 0.326
liposaccharide metabolic process GO:1903509 27 0.323
positive regulation of glial cell proliferation GO:0060252 4 0.323
wnt signaling pathway GO:0016055 188 0.322
purine containing compound metabolic process GO:0072521 311 0.321
mesenchymal cell differentiation GO:0048762 107 0.320
morphogenesis of embryonic epithelium GO:0016331 159 0.320
positive regulation of autophagy GO:0010508 9 0.320
Fly
establishment of organelle localization GO:0051656 122 0.319
regulation of transferase activity GO:0051338 263 0.318
stem cell differentiation GO:0048863 268 0.317
regulation of microtubule based process GO:0032886 52 0.317
b cell activation GO:0042113 161 0.317
regulation of epithelial cell migration GO:0010632 35 0.316
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 2 0.313
cellular macromolecule catabolic process GO:0044265 206 0.313
determination of adult lifespan GO:0008340 11 0.313
Worm
regulation of apoptotic signaling pathway GO:2001233 197 0.313
Human
axon target recognition GO:0007412 4 0.311
regulation of protein import into nucleus GO:0042306 52 0.310
purine containing compound catabolic process GO:0072523 213 0.309
oocyte differentiation GO:0009994 35 0.309
positive regulation of secretion GO:0051047 130 0.308
ubiquitin dependent protein catabolic process GO:0006511 129 0.308
negative regulation of neurotransmitter secretion GO:0046929 5 0.307
regulation of neuronal synaptic plasticity GO:0048168 30 0.307
cellular response to peptide GO:1901653 92 0.307
Rat Fly
compound eye development GO:0048749 1 0.305
glycosyl compound catabolic process GO:1901658 206 0.305
cellular response to nutrient levels GO:0031669 64 0.305
Worm
cellular lipid metabolic process GO:0044255 323 0.302
camp metabolic process GO:0046058 40 0.302
regulation of cardiac cell fate specification GO:2000043 1 0.302
aromatic compound catabolic process GO:0019439 286 0.301
regulation of reactive oxygen species metabolic process GO:2000377 40 0.298
positive regulation of growth GO:0045927 104 0.298
central nervous system neuron differentiation GO:0021953 162 0.298
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.298
intracellular protein transport GO:0006886 204 0.295
negative regulation of phosphorus metabolic process GO:0010563 184 0.294
positive regulation of rac protein signal transduction GO:0035022 1 0.294
regulation of protein tyrosine kinase activity GO:0061097 17 0.293
establishment or maintenance of cell polarity GO:0007163 86 0.293
cellular response to vitamin GO:0071295 2 0.293
carbohydrate derivative catabolic process GO:1901136 231 0.289
regulation of leukocyte proliferation GO:0070663 121 0.286
endocardium development GO:0003157 10 0.284
sensory organ morphogenesis GO:0090596 242 0.284
cellular metal ion homeostasis GO:0006875 151 0.284
transmission of nerve impulse GO:0019226 76 0.282
positive regulation of protein transport GO:0051222 93 0.281
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.281
protein targeting GO:0006605 143 0.281
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.279
glucose metabolic process GO:0006006 92 0.277
regulation of heart contraction GO:0008016 77 0.274
Mouse
negative regulation of neuron death GO:1901215 98 0.274
negative regulation of cellular component organization GO:0051129 194 0.274
glial cell differentiation GO:0010001 131 0.273
divalent inorganic cation homeostasis GO:0072507 138 0.273
cellular ion homeostasis GO:0006873 165 0.272
monocarboxylic acid metabolic process GO:0032787 191 0.271
protein localization to nucleus GO:0034504 121 0.270
positive regulation of programmed cell death GO:0043068 218 0.269
Rat
regulation of anatomical structure size GO:0090066 178 0.269
Rat
myeloid leukocyte differentiation GO:0002573 119 0.267
negative regulation of organ growth GO:0046621 17 0.266
regulation of cellular response to hypoxia GO:1900037 2 0.264
Rat
cellular response to decreased oxygen levels GO:0036294 18 0.263
protein oligomerization GO:0051259 67 0.263
extracellular matrix dependent thymocyte migration GO:0072680 1 0.262
collagen metabolic process GO:0032963 17 0.261
leukocyte proliferation GO:0070661 172 0.260
negative regulation of t cell activation GO:0050868 65 0.259
regulation of lymphocyte activation GO:0051249 240 0.257
positive regulation of hydrolase activity GO:0051345 148 0.256
positive regulation of neuron death GO:1901216 28 0.256
positive regulation of behavior GO:0048520 40 0.256
cellular response to cytokine stimulus GO:0071345 189 0.254
Human Rat
myeloid leukocyte migration GO:0097529 57 0.254
eye photoreceptor cell differentiation GO:0001754 41 0.254
negative regulation of neuron apoptotic process GO:0043524 92 0.254
response to decreased oxygen levels GO:0036293 59 0.253
purine nucleotide catabolic process GO:0006195 211 0.252
regulation of hormone levels GO:0010817 211 0.250
cellular calcium ion homeostasis GO:0006874 119 0.250
spermatid differentiation GO:0048515 115 0.250
inflammatory response GO:0006954 244 0.248
connective tissue development GO:0061448 179 0.248
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.247
intrinsic apoptotic signaling pathway GO:0097193 132 0.247
Human
regulation of metal ion transport GO:0010959 106 0.247
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.245
Human
inorganic cation transmembrane transport GO:0098662 207 0.245
extracellular structure organization GO:0043062 148 0.244
cellular protein complex assembly GO:0043623 116 0.244
response to oxidative stress GO:0006979 123 0.243
tyrosine phosphorylation of stat5 protein GO:0042506 9 0.243
cardiac chamber development GO:0003205 108 0.243
single organism nuclear import GO:1902593 95 0.242
leukocyte chemotaxis GO:0030595 69 0.242
regulation of angiogenesis GO:0045765 81 0.240
male gamete generation GO:0048232 285 0.240
negative regulation of necroptotic process GO:0060546 9 0.240
divalent metal ion transport GO:0070838 172 0.239
hemostasis GO:0007599 78 0.238
negative regulation of molecular function GO:0044092 258 0.238
connective tissue replacement involved in inflammatory response wound healing GO:0002248 3 0.238
activation of adenylate cyclase activity GO:0007190 4 0.238
positive regulation of epidermal growth factor activated receptor activity GO:0045741 2 0.237
positive regulation of map kinase activity GO:0043406 84 0.237
anion transport GO:0006820 177 0.236
tissue homeostasis GO:0001894 115 0.235
Mouse
regulation of cellular component size GO:0032535 121 0.233
Rat
regulation of calcium ion transport GO:0051924 69 0.233
activation of mapkk activity GO:0000186 15 0.232
skeletal muscle organ development GO:0060538 163 0.232
regulation of organelle organization GO:0033043 289 0.231
regulation of endothelial cell chemotaxis GO:2001026 1 0.231
peptidyl tyrosine modification GO:0018212 145 0.231
response to organic cyclic compound GO:0014070 198 0.229
Rat
regulation of cell growth involved in cardiac muscle cell development GO:0061050 3 0.228
mesenchymal cell development GO:0014031 93 0.228
regulation of peptide transport GO:0090087 91 0.227
embryonic skeletal system development GO:0048706 120 0.226
macroautophagy GO:0016236 21 0.225
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.225
leukocyte differentiation GO:0002521 342 0.224
regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061418 2 0.224
Human
pigmentation GO:0043473 71 0.224
protein localization to nuclear envelope GO:0090435 2 0.223
leukocyte migration GO:0050900 124 0.222
microtubule based process GO:0007017 236 0.222
Human
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.222
regulation of epithelial cell proliferation GO:0050678 141 0.220
necroptotic process GO:0070266 21 0.218
inner ear receptor cell differentiation GO:0060113 61 0.217
organelle localization GO:0051640 179 0.216
regulation of nucleoside metabolic process GO:0009118 130 0.216
defense response to other organism GO:0098542 197 0.216
cyclic nucleotide biosynthetic process GO:0009190 44 0.216
muscle cell differentiation GO:0042692 261 0.215
Mouse
positive regulation of thymocyte migration GO:2000412 2 0.215
inorganic ion transmembrane transport GO:0098660 234 0.215
protein polymerization GO:0051258 57 0.215
regulation of peptide hormone secretion GO:0090276 75 0.214
body morphogenesis GO:0010171 45 0.214
epithelial cell migration GO:0010631 63 0.214
keratinocyte migration GO:0051546 3 0.212
skin morphogenesis GO:0043589 38 0.210
cell fate specification GO:0001708 72 0.209
blood vessel endothelial cell migration GO:0043534 23 0.209
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.208
syncytium formation GO:0006949 43 0.207
response to dexamethasone GO:0071548 8 0.206
positive regulation of secretion by cell GO:1903532 114 0.205

Hif1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.974
disease of cellular proliferation DOID:14566 0 0.974
organ system cancer DOID:0050686 0 0.974
noonan syndrome DOID:3490 0 0.517