Mus musculus

0 known processes

Hspa4

heat shock protein 4

(Aliases: AI317151,Hsp70RY,70kDa,APG-2,Hsp110,KIAA4025,mKIAA4025)

Hspa4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein refolding GO:0042026 1 0.495
Yeast
cellular macromolecule catabolic process GO:0044265 206 0.441
establishment of protein localization to organelle GO:0072594 118 0.350
Human
protein localization to organelle GO:0033365 185 0.238
Human
macromolecule catabolic process GO:0009057 281 0.230
protein import GO:0017038 101 0.199
Human
organelle disassembly GO:1903008 2 0.171
actin cytoskeleton organization GO:0030036 220 0.154
posttranscriptional regulation of gene expression GO:0010608 155 0.154
aromatic compound catabolic process GO:0019439 286 0.151
Yeast
cytoplasmic transport GO:0016482 234 0.143
Human
organic cyclic compound catabolic process GO:1901361 295 0.139
Yeast
protein catabolic process GO:0030163 221 0.123
protein localization to nucleus GO:0034504 121 0.121
protein import into nucleus GO:0006606 95 0.119
nuclear transport GO:0051169 139 0.117
myosin filament organization GO:0031033 3 0.116
nucleoside phosphate metabolic process GO:0006753 338 0.115
Yeast
glycosyl compound metabolic process GO:1901657 246 0.112
Yeast
ribose phosphate metabolic process GO:0019693 291 0.110
Yeast
intracellular protein transport GO:0006886 204 0.109
Human
single organism nuclear import GO:1902593 95 0.107
negative regulation of cellular protein metabolic process GO:0032269 247 0.106
Rat
ribonucleoside triphosphate metabolic process GO:0009199 220 0.105
Yeast
nucleoside metabolic process GO:0009116 246 0.102
Yeast
nucleotide catabolic process GO:0009166 217 0.100
Yeast
regulation of cellular catabolic process GO:0031329 242 0.096
striated muscle myosin thick filament assembly GO:0071688 1 0.094
cellular nitrogen compound catabolic process GO:0044270 280 0.091
Yeast
cell adhesion GO:0007155 329 0.088
heterocycle catabolic process GO:0046700 280 0.087
Yeast
organonitrogen compound catabolic process GO:1901565 264 0.087
Yeast
modification dependent protein catabolic process GO:0019941 133 0.086
organelle assembly GO:0070925 177 0.083
axonogenesis GO:0007409 274 0.081
nucleobase containing small molecule metabolic process GO:0055086 352 0.080
Yeast
nucleocytoplasmic transport GO:0006913 139 0.080
nuclear import GO:0051170 95 0.078
oocyte axis specification GO:0007309 2 0.076
nucleoside catabolic process GO:0009164 206 0.075
Yeast
oocyte anterior posterior axis specification GO:0007314 2 0.075
ubiquitin dependent protein catabolic process GO:0006511 129 0.075
purine nucleotide catabolic process GO:0006195 211 0.075
Yeast
nucleoside phosphate catabolic process GO:1901292 222 0.074
Yeast
ribonucleoside metabolic process GO:0009119 245 0.072
Yeast
mrna metabolic process GO:0016071 84 0.070
purine nucleoside triphosphate metabolic process GO:0009144 226 0.069
Yeast
ribonucleoside triphosphate catabolic process GO:0009203 199 0.067
Yeast
intracellular mrna localization GO:0008298 4 0.066
purine ribonucleotide metabolic process GO:0009150 290 0.065
Yeast
endocytosis GO:0006897 168 0.063
Worm
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.060
Yeast
regulation of organelle organization GO:0033043 289 0.059
protein modification by small protein conjugation or removal GO:0070647 207 0.057
protein ubiquitination GO:0016567 171 0.056
purine nucleoside catabolic process GO:0006152 205 0.056
Yeast
amine metabolic process GO:0009308 45 0.054
purine nucleotide metabolic process GO:0006163 302 0.053
Yeast
ribonucleoside catabolic process GO:0042454 206 0.053
Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.052
organophosphate catabolic process GO:0046434 232 0.052
Yeast
regulation of intracellular transport GO:0032386 159 0.052
glycosyl compound catabolic process GO:1901658 206 0.051
Yeast
myosin filament assembly GO:0031034 2 0.051
regulation of establishment of protein localization GO:0070201 181 0.051
carbohydrate derivative catabolic process GO:1901136 231 0.050
Yeast
oocyte construction GO:0007308 2 0.049
modification dependent macromolecule catabolic process GO:0043632 133 0.049
rna interference GO:0016246 2 0.049
actin filament organization GO:0007015 113 0.046
purine nucleoside triphosphate catabolic process GO:0009146 203 0.046
Yeast
regulation of protein transport GO:0051223 163 0.046
purine nucleoside metabolic process GO:0042278 241 0.045
Yeast
ribonucleotide metabolic process GO:0009259 291 0.042
Yeast
cellular protein complex assembly GO:0043623 116 0.042
Human
cellular amine metabolic process GO:0044106 44 0.042
nucleoside triphosphate catabolic process GO:0009143 205 0.042
Yeast
protein modification by small protein conjugation GO:0032446 187 0.042
ribonucleotide catabolic process GO:0009261 208 0.041
Yeast
positive regulation of cytoplasmic transport GO:1903651 40 0.041
dna metabolic process GO:0006259 303 0.040
response to growth factor GO:0070848 198 0.040
positive regulation of proteolysis GO:0045862 85 0.040
purine ribonucleoside metabolic process GO:0046128 241 0.038
Yeast
germ cell development GO:0007281 185 0.037
cellular protein catabolic process GO:0044257 155 0.037
compound eye development GO:0048749 1 0.037
regulation of cellular component biogenesis GO:0044087 181 0.037
regulation of proteolysis GO:0030162 164 0.037
regulation of cell cycle GO:0051726 281 0.036
nuclear export GO:0051168 34 0.036
purine containing compound metabolic process GO:0072521 311 0.036
Yeast
mitotic cell cycle process GO:1903047 159 0.035
regulation of protein localization GO:0032880 231 0.035
double strand break repair GO:0006302 48 0.035
cellular response to cytokine stimulus GO:0071345 189 0.035
membrane organization GO:0061024 245 0.035
Human
angiogenesis GO:0001525 201 0.034
Rat
carbohydrate derivative biosynthetic process GO:1901137 183 0.034
pole plasm assembly GO:0007315 2 0.034
rhythmic process GO:0048511 174 0.033
cellular component assembly involved in morphogenesis GO:0010927 139 0.033
rna splicing GO:0008380 54 0.033
muscle cell differentiation GO:0042692 261 0.033
rna processing GO:0006396 105 0.032
dephosphorylation GO:0016311 129 0.032
regulation of cellular response to stress GO:0080135 159 0.032
purine containing compound catabolic process GO:0072523 213 0.032
Yeast
positive regulation of cell development GO:0010720 237 0.031
positive regulation of protein transport GO:0051222 93 0.031
response to organonitrogen compound GO:0010243 246 0.031
urogenital system development GO:0001655 261 0.031
Rat
developmental maturation GO:0021700 193 0.031
locomotory behavior GO:0007626 195 0.030
regulation of cell projection organization GO:0031344 206 0.030
rna splicing via transesterification reactions GO:0000375 43 0.030
nucleotide metabolic process GO:0009117 332 0.030
Yeast
neuron apoptotic process GO:0051402 142 0.030
cell type specific apoptotic process GO:0097285 268 0.030
cellular response to dna damage stimulus GO:0006974 207 0.030
nucleoside triphosphate metabolic process GO:0009141 230 0.030
Yeast
negative regulation of protein metabolic process GO:0051248 282 0.029
Rat
blood vessel morphogenesis GO:0048514 285 0.029
Rat
regulation of cell motility GO:2000145 236 0.029
nuclear division GO:0000280 158 0.029
maternal determination of anterior posterior axis embryo GO:0008358 2 0.029
regulation of cell migration GO:0030334 219 0.028
purine ribonucleoside catabolic process GO:0046130 205 0.028
Yeast
organelle fission GO:0048285 170 0.028
positive regulation of hydrolase activity GO:0051345 148 0.028
microtubule based process GO:0007017 236 0.028
regulation of protein catabolic process GO:0042176 108 0.028
nucleoside monophosphate catabolic process GO:0009125 59 0.028
Yeast
synapse organization GO:0050808 125 0.027
ribonucleoprotein complex disassembly GO:0032988 3 0.027
translation GO:0006412 93 0.027
regulation of kinase activity GO:0043549 249 0.027
development of primary sexual characteristics GO:0045137 143 0.027
Worm
response to oxidative stress GO:0006979 123 0.027
regulation of intracellular protein transport GO:0033157 82 0.027
regionalization GO:0003002 337 0.027
ribonucleoside monophosphate metabolic process GO:0009161 80 0.026
Yeast
proteasomal protein catabolic process GO:0010498 98 0.026
regulation of neuron projection development GO:0010975 169 0.026
positive regulation of cellular component biogenesis GO:0044089 94 0.026
body morphogenesis GO:0010171 45 0.026
Worm
regulation of cytoplasmic transport GO:1903649 112 0.026
cellular amino acid metabolic process GO:0006520 103 0.025
regulation of neuron differentiation GO:0045664 281 0.025
protein targeting GO:0006605 143 0.025
Human
positive regulation of apoptotic process GO:0043065 217 0.025
adult behavior GO:0030534 135 0.025
positive regulation of cell death GO:0010942 224 0.025
fertilization GO:0009566 127 0.025
cellular ketone metabolic process GO:0042180 84 0.025
response to peptide GO:1901652 136 0.025
regulation of cellular amine metabolic process GO:0033238 20 0.024
establishment of protein localization to membrane GO:0090150 54 0.024
Human
mitotic cell cycle GO:0000278 195 0.024
negative regulation of molecular function GO:0044092 258 0.024
Rat
positive regulation of cellular catabolic process GO:0031331 148 0.024
regulation of transferase activity GO:0051338 263 0.024
positive regulation of cell projection organization GO:0031346 95 0.024
negative regulation of cell proliferation GO:0008285 296 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.023
Yeast
positive regulation of intracellular transport GO:0032388 70 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.023
chemotaxis GO:0006935 247 0.023
ribonucleoprotein complex subunit organization GO:0071826 28 0.023
regulation of cytoskeleton organization GO:0051493 122 0.023
cell maturation GO:0048469 127 0.022
small gtpase mediated signal transduction GO:0007264 97 0.022
muscle system process GO:0003012 141 0.022
positive regulation of cell cycle GO:0045787 92 0.022
microtubule cytoskeleton organization GO:0000226 157 0.022
ribonucleoprotein complex localization GO:0071166 1 0.022
protein folding GO:0006457 28 0.022
Yeast
forebrain development GO:0030900 302 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
regulation of anatomical structure size GO:0090066 178 0.021
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
regulation of mitotic cell cycle phase transition GO:1901990 73 0.021
ribonucleoside monophosphate catabolic process GO:0009158 57 0.021
Yeast
cell recognition GO:0008037 83 0.021
neuron death GO:0070997 154 0.021
nitrogen compound transport GO:0071705 271 0.021
establishment of organelle localization GO:0051656 122 0.021
purine ribonucleotide catabolic process GO:0009154 208 0.020
Yeast
actomyosin structure organization GO:0031032 56 0.020
negative regulation of cellular component organization GO:0051129 194 0.020
sperm egg recognition GO:0035036 37 0.020
pore complex assembly GO:0046931 3 0.020
response to transforming growth factor beta GO:0071559 88 0.020
inflammatory response GO:0006954 244 0.020
meiotic cell cycle GO:0051321 122 0.020
chromatin organization GO:0006325 206 0.020
telencephalon development GO:0021537 186 0.020
regulation of transposition GO:0010528 2 0.019
stem cell differentiation GO:0048863 268 0.019
rna localization GO:0006403 23 0.019
atp metabolic process GO:0046034 75 0.019
Yeast
regulation of cellular amino acid metabolic process GO:0006521 5 0.019
dendrite development GO:0016358 115 0.019
chromatin modification GO:0016568 187 0.019
single fertilization GO:0007338 82 0.019
pallium development GO:0021543 120 0.019
transmembrane transport GO:0055085 412 0.019
Human
organonitrogen compound biosynthetic process GO:1901566 192 0.019
cellular protein complex disassembly GO:0043624 36 0.019
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.019
lipid biosynthetic process GO:0008610 179 0.018
receptor mediated endocytosis GO:0006898 51 0.018
Worm
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.018
regulation of protein stability GO:0031647 52 0.018
adult locomotory behavior GO:0008344 91 0.018
atp catabolic process GO:0006200 55 0.018
Yeast
gene silencing by rna GO:0031047 19 0.018
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000466 1 0.018
cellular response to growth factor stimulus GO:0071363 197 0.017
regulation of protein ubiquitination GO:0031396 52 0.017
immune effector process GO:0002252 321 0.017
positive regulation of nervous system development GO:0051962 221 0.017
maintenance of location GO:0051235 89 0.017
small molecule biosynthetic process GO:0044283 132 0.017
fatty acid metabolic process GO:0006631 121 0.017
protein targeting to mitochondrion GO:0006626 6 0.017
Human
anatomical structure homeostasis GO:0060249 145 0.017
regulation of cellular ketone metabolic process GO:0010565 66 0.016
negative regulation of phosphate metabolic process GO:0045936 184 0.016
Rat
response to organic cyclic compound GO:0014070 198 0.016
muscle contraction GO:0006936 101 0.016
mitochondrion organization GO:0007005 134 0.016
Human
response to radiation GO:0009314 165 0.016
cation transport GO:0006812 399 0.016
purine nucleoside monophosphate metabolic process GO:0009126 81 0.016
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 57 0.016
Yeast
regulation of membrane potential GO:0042391 192 0.016
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.016
mrna processing GO:0006397 63 0.016
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 1 0.015
positive regulation of intracellular protein transport GO:0090316 42 0.015
learning GO:0007612 98 0.015
single organismal cell cell adhesion GO:0016337 131 0.015
nucleus organization GO:0006997 45 0.015
purine nucleoside monophosphate catabolic process GO:0009128 58 0.015
Yeast
regulation of cell cycle process GO:0010564 160 0.015
regulation of defense response GO:0031347 233 0.015
regulation of nucleocytoplasmic transport GO:0046822 73 0.015
response to peptide hormone GO:0043434 127 0.015
circadian rhythm GO:0007623 114 0.015
positive regulation of transferase activity GO:0051347 167 0.015
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.015
positive regulation of protein localization to nucleus GO:1900182 30 0.015
regulation of ion transport GO:0043269 215 0.015
mrna splicing via spliceosome GO:0000398 43 0.015
response to extracellular stimulus GO:0009991 127 0.015
response to light stimulus GO:0009416 135 0.015
nucleoside monophosphate metabolic process GO:0009123 85 0.014
Yeast
ossification GO:0001503 216 0.014
maturation of 5 8s rrna GO:0000460 1 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 43 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 57 0.014
response to insulin GO:0032868 100 0.014
regulation of cell cycle phase transition GO:1901987 77 0.014
regulation of muscle system process GO:0090257 80 0.014
circulatory system process GO:0003013 197 0.014
positive regulation of mrna metabolic process GO:1903313 17 0.014
regulation of response to wounding GO:1903034 189 0.014
blood circulation GO:0008015 195 0.014
multicellular organismal homeostasis GO:0048871 164 0.014
mitotic cell cycle checkpoint GO:0007093 31 0.014
regulation of neuron apoptotic process GO:0043523 122 0.014
regulation of cellular component size GO:0032535 121 0.014
regulation of multi organism process GO:0043900 111 0.014
skeletal muscle organ development GO:0060538 163 0.014
nucleoside phosphate biosynthetic process GO:1901293 79 0.014
posttranscriptional gene silencing GO:0016441 10 0.014
ras protein signal transduction GO:0007265 77 0.014
meiotic cell cycle process GO:1903046 77 0.014
response to temperature stimulus GO:0009266 55 0.014
Rat
sensory perception GO:0007600 245 0.014
cellular lipid metabolic process GO:0044255 323 0.014
neuron migration GO:0001764 122 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.014
Yeast
mitotic cytokinesis GO:0000281 4 0.014
innate immune response GO:0045087 157 0.014
regulation of chromosome organization GO:0033044 83 0.014
lipid localization GO:0010876 126 0.013
regulation of mitotic cell cycle GO:0007346 126 0.013
cajal body organization GO:0030576 1 0.013
mitochondrial translation GO:0032543 4 0.013
organophosphate biosynthetic process GO:0090407 122 0.013
cell cell recognition GO:0009988 44 0.013
positive regulation of organelle organization GO:0010638 128 0.013
negative regulation of transferase activity GO:0051348 85 0.013
organelle localization GO:0051640 179 0.013
epithelial tube morphogenesis GO:0060562 303 0.013
regulation of hydrolase activity GO:0051336 246 0.013
proteasome assembly GO:0043248 1 0.013
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.013
regulation of endopeptidase activity GO:0052548 89 0.013
cytokine production GO:0001816 319 0.013
regulation of protein serine threonine kinase activity GO:0071900 157 0.013
lateral inhibition GO:0046331 1 0.013
posttranscriptional gene silencing by rna GO:0035194 10 0.012
lipid transport GO:0006869 98 0.012
negative regulation of cell development GO:0010721 169 0.012
stem cell development GO:0048864 219 0.012
negative regulation of transposition GO:0010529 2 0.012
regulation of circadian rhythm GO:0042752 58 0.012
regulation of translation GO:0006417 71 0.012
regulation of homeostatic process GO:0032844 182 0.012
cation transmembrane transport GO:0098655 266 0.012
mapk cascade GO:0000165 281 0.012
gland development GO:0048732 330 0.012
regulation of cell adhesion GO:0030155 154 0.012
stress granule disassembly GO:0035617 2 0.012
regulation of protein complex assembly GO:0043254 83 0.012
positive regulation of cell migration GO:0030335 109 0.012
regulation of peptidase activity GO:0052547 96 0.012
muscle cell development GO:0055001 133 0.012
spermatid differentiation GO:0048515 115 0.012
establishment or maintenance of cell polarity GO:0007163 86 0.012
positive regulation of programmed cell death GO:0043068 218 0.012
protein modification by small protein removal GO:0070646 21 0.012
stress activated mapk cascade GO:0051403 80 0.012
negative regulation of cell cycle GO:0045786 123 0.012
positive regulation of protein modification process GO:0031401 299 0.011
negative regulation of immune system process GO:0002683 209 0.011
cognition GO:0050890 149 0.011
renal system development GO:0072001 225 0.011
Rat
oocyte differentiation GO:0009994 35 0.011
regulation of protein targeting GO:1903533 61 0.011
endomembrane system organization GO:0010256 147 0.011
intrinsic apoptotic signaling pathway GO:0097193 132 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.011
regulation of metal ion transport GO:0010959 106 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 40 0.011
developmental growth involved in morphogenesis GO:0060560 138 0.011
asymmetric stem cell division GO:0098722 3 0.011
positive regulation of protein phosphorylation GO:0001934 242 0.011
negative regulation of neuron apoptotic process GO:0043524 92 0.011
positive regulation of chromosome organization GO:2001252 33 0.011
transmission of nerve impulse GO:0019226 76 0.011
positive regulation of cell motility GO:2000147 116 0.011
regulation of cytokine production GO:0001817 266 0.011
gtp metabolic process GO:0046039 144 0.011
ncrna processing GO:0034470 26 0.011
positive regulation of peptidase activity GO:0010952 49 0.011
regulation of stress activated mapk cascade GO:0032872 69 0.011
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.011
positive regulation of homeostatic process GO:0032846 64 0.011
positive regulation of growth GO:0045927 104 0.010
molting cycle GO:0042303 90 0.010
digestive tract morphogenesis GO:0048546 147 0.010
binding of sperm to zona pellucida GO:0007339 34 0.010
cellular response to hormone stimulus GO:0032870 150 0.010
synaptic transmission GO:0007268 329 0.010
regulation of hormone levels GO:0010817 211 0.010
regulation of protein kinase activity GO:0045859 232 0.010
regulation of proteasomal protein catabolic process GO:0061136 46 0.010
positive regulation of kinase activity GO:0033674 155 0.010
regulation of protein localization to nucleus GO:1900180 60 0.010
spindle organization GO:0007051 28 0.010

Hspa4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
immune system cancer DOID:0060083 0 0.010
hematologic cancer DOID:2531 0 0.010