Mus musculus

0 known processes

Igh

immunoglobulin heavy chain complex

(Aliases: MGC6529,MGC102662,MGC102661,MGC6628,MGC28019,MGC6740,MGC6522,MGC118125,MGC103226,MGC6486,MGC68378,MGC36307,MGC68276)

Igh biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
histamine production involved in inflammatory response GO:0002349 1 1.000
immunoglobulin mediated immune response GO:0016064 69 1.000
adaptive immune response GO:0002250 155 1.000
b cell activation GO:0042113 161 1.000
negative regulation of b cell proliferation GO:0030889 13 1.000
interleukin 5 secretion GO:0072603 2 1.000
b cell proliferation GO:0042100 53 1.000
regulation of cytokine biosynthetic process GO:0042035 59 1.000
lymphocyte differentiation GO:0030098 242 1.000
positive regulation of cytokine biosynthetic process GO:0042108 40 1.000
interleukin 10 secretion GO:0072608 4 1.000
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 1.000
regulation of b cell differentiation GO:0045577 23 1.000
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 1.000
positive regulation of adaptive immune response GO:0002821 61 0.999
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.999
positive regulation of b cell proliferation GO:0030890 24 0.999
negative regulation of interleukin 5 secretion GO:2000663 1 0.999
lymphocyte homeostasis GO:0002260 64 0.999
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.999
immunoglobulin secretion GO:0048305 17 0.999
regulation of interleukin 13 secretion GO:2000665 2 0.999
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.999
b cell mediated immunity GO:0019724 71 0.999
somatic diversification of immune receptors GO:0002200 53 0.998
myeloid dendritic cell differentiation GO:0043011 16 0.998
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.998
regulation of b cell activation GO:0050864 81 0.998
b cell receptor signaling pathway GO:0050853 20 0.998
lymphocyte mediated immunity GO:0002449 139 0.997
cellular response to dna damage stimulus GO:0006974 207 0.997
positive regulation of b cell activation GO:0050871 49 0.997
positive regulation of immune effector process GO:0002699 107 0.997
dna metabolic process GO:0006259 303 0.997
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.996
regulation of leukocyte apoptotic process GO:2000106 56 0.996
regulation of calcium ion transport into cytosol GO:0010522 31 0.996
regulation of leukocyte mediated immunity GO:0002703 104 0.995
positive regulation of programmed cell death GO:0043068 218 0.995
tumor necrosis factor mediated signaling pathway GO:0033209 13 0.995
positive regulation of leukocyte mediated immunity GO:0002705 70 0.995
toll like receptor signaling pathway GO:0002224 38 0.993
regulation of leukocyte proliferation GO:0070663 121 0.993
regulation of b cell proliferation GO:0030888 39 0.992
leukocyte mediated immunity GO:0002443 174 0.992
sensitization GO:0046960 2 0.992
regulation of lipid transport GO:0032368 36 0.991
defense response to other organism GO:0098542 197 0.991
b cell differentiation GO:0030183 78 0.991
lymphocyte apoptotic process GO:0070227 54 0.991
negative regulation of leukocyte differentiation GO:1902106 51 0.990
regulation of b cell apoptotic process GO:0002902 13 0.990
somatic diversification of immunoglobulins GO:0016445 43 0.990
immune response activating signal transduction GO:0002757 116 0.989
alpha beta t cell differentiation GO:0046632 69 0.988
negative regulation of b cell activation GO:0050869 27 0.988
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.988
positive regulation of leukocyte apoptotic process GO:2000108 21 0.988
dna recombination GO:0006310 92 0.987
response to amino acid GO:0043200 37 0.984
regulation of b cell mediated immunity GO:0002712 37 0.983
regulation of neutrophil differentiation GO:0045658 2 0.983
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.983
homeostasis of number of cells GO:0048872 210 0.982
interleukin 13 secretion GO:0072611 2 0.981
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.980
leukocyte proliferation GO:0070661 172 0.980
positive regulation of cell death GO:0010942 224 0.979
t cell proliferation GO:0042098 120 0.979
regulation of interleukin 10 secretion GO:2001179 4 0.978
regulation of gamma delta t cell differentiation GO:0045586 9 0.974
regulation of interleukin 5 secretion GO:2000662 2 0.974
thymic t cell selection GO:0045061 22 0.972
positive regulation of lipid transport GO:0032370 22 0.971
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.970
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.970
b cell homeostasis GO:0001782 34 0.969
regulation of cellular amino acid metabolic process GO:0006521 5 0.968
positive regulation of t cell activation GO:0050870 101 0.968
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.968
positive regulation of leukocyte proliferation GO:0070665 73 0.965
positive regulation of interleukin 2 production GO:0032743 19 0.965
programmed necrotic cell death GO:0097300 28 0.964
t helper 2 cell differentiation GO:0045064 12 0.963
antigen receptor mediated signaling pathway GO:0050851 64 0.962
cellular senescence GO:0090398 11 0.961
regulation of cellular ketone metabolic process GO:0010565 66 0.960
lymph node development GO:0048535 18 0.958
regulation of apoptotic signaling pathway GO:2001233 197 0.956
telomere capping GO:0016233 4 0.953
positive regulation of homeostatic process GO:0032846 64 0.949
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.947
positive regulation of intrinsic apoptotic signaling pathway GO:2001244 25 0.946
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.943
glial cell apoptotic process GO:0034349 3 0.942
innate immune response activating signal transduction GO:0002758 50 0.942
regulation of lymphocyte proliferation GO:0050670 117 0.940
b cell activation involved in immune response GO:0002312 50 0.938
t helper 2 cell cytokine production GO:0035745 4 0.938
positive regulation of immunoglobulin mediated immune response GO:0002891 26 0.938
regulation of lymphocyte mediated immunity GO:0002706 84 0.937
neutrophil differentiation GO:0030223 3 0.935
mammary gland epithelium development GO:0061180 65 0.934
humoral immune response GO:0006959 57 0.933
release of cytochrome c from mitochondria GO:0001836 23 0.932
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.927
somatic cell dna recombination GO:0016444 51 0.926
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.926
regulation of response to wounding GO:1903034 189 0.926
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.924
interleukin 10 production GO:0032613 23 0.924
lipid transport GO:0006869 98 0.923
positive regulation of cellular amine metabolic process GO:0033240 5 0.920
positive regulation of podosome assembly GO:0071803 3 0.918
regulation of stress activated mapk cascade GO:0032872 69 0.918
cellular chemical homeostasis GO:0055082 215 0.918
apoptotic signaling pathway GO:0097190 306 0.917
circadian rhythm GO:0007623 114 0.916
cytokine production involved in immune response GO:0002367 34 0.916
immune response regulating signaling pathway GO:0002764 125 0.914
alpha beta t cell lineage commitment GO:0002363 7 0.913
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.911
positive regulation of multi organism process GO:0043902 26 0.910
negative regulation of cellular amine metabolic process GO:0033239 1 0.907
histamine secretion GO:0001821 1 0.906
leukocyte differentiation GO:0002521 342 0.906
regulation of calcium ion transport GO:0051924 69 0.905
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.904
response to inorganic substance GO:0010035 96 0.902
regulation of immunoglobulin mediated immune response GO:0002889 37 0.901
negative regulation of cell activation GO:0050866 111 0.900
anatomical structure homeostasis GO:0060249 145 0.900
positive regulation of cytokine production GO:0001819 174 0.899
hematopoietic progenitor cell differentiation GO:0002244 143 0.897
cellular amine metabolic process GO:0044106 44 0.897
regulation of homeostatic process GO:0032844 182 0.895
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.893
positive regulation of cell development GO:0010720 237 0.889
immunoglobulin production GO:0002377 73 0.887
extrinsic apoptotic signaling pathway GO:0097191 126 0.886
t cell activation involved in immune response GO:0002286 43 0.884
regulation of intracellular transport GO:0032386 159 0.881
t cell differentiation GO:0030217 174 0.880
macromolecule methylation GO:0043414 120 0.878
positive regulation of mapk cascade GO:0043410 170 0.878
chromatin organization GO:0006325 206 0.872
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.871
regulation of chromatin modification GO:1903308 57 0.870
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.869
tissue remodeling GO:0048771 102 0.868
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.864
regulation of interleukin 2 production GO:0032663 28 0.861
regulation of endopeptidase activity GO:0052548 89 0.860
metal ion homeostasis GO:0055065 189 0.857
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.853
lymphocyte proliferation GO:0046651 164 0.851
glycosphingolipid metabolic process GO:0006687 18 0.851
tyrosine phosphorylation of stat protein GO:0007260 23 0.844
dendritic cell differentiation GO:0097028 26 0.843
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.839
positive regulation of intracellular transport GO:0032388 70 0.838
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.833
cellular response to external stimulus GO:0071496 88 0.829
t cell differentiation in thymus GO:0033077 77 0.828
regulation of zinc ion transmembrane transport GO:0071580 2 0.827
regulation of ion transport GO:0043269 215 0.827
regulation of homotypic cell cell adhesion GO:0034110 13 0.816
positive regulation of translational initiation GO:0045948 4 0.814
activation of immune response GO:0002253 138 0.813
positive t cell selection GO:0043368 23 0.812
positive regulation of apoptotic process GO:0043065 217 0.812
positive regulation of interleukin 12 production GO:0032735 21 0.812
hypomethylation of cpg island GO:0044029 1 0.808
regulation of cell activation GO:0050865 289 0.808
amine metabolic process GO:0009308 45 0.806
positive regulation of myeloid cell differentiation GO:0045639 43 0.805
regulation of cytokine production GO:0001817 266 0.801
regulation of response to biotic stimulus GO:0002831 38 0.800
cell aging GO:0007569 35 0.799
t helper cell differentiation GO:0042093 28 0.798
negative regulation of phosphorus metabolic process GO:0010563 184 0.797
regulation of t helper 2 cell cytokine production GO:2000551 3 0.794
response to dsrna GO:0043331 30 0.793
cellular response to molecule of fungal origin GO:0071226 2 0.786
v d j recombination GO:0033151 14 0.786
myeloid leukocyte activation GO:0002274 83 0.785
positive regulation of acute inflammatory response to antigenic stimulus GO:0002866 7 0.780
release of sequestered calcium ion into cytosol GO:0051209 42 0.778
response to oxidative stress GO:0006979 123 0.776
histamine secretion involved in inflammatory response GO:0002441 1 0.776
inflammatory response GO:0006954 244 0.774
regulation of immunoglobulin secretion GO:0051023 12 0.771
pattern recognition receptor signaling pathway GO:0002221 47 0.769
protein alkylation GO:0008213 81 0.768
histamine transport GO:0051608 2 0.766
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.766
skin development GO:0043588 220 0.765
regulation of cellular response to stress GO:0080135 159 0.763
b cell apoptotic process GO:0001783 19 0.762
regulation of map kinase activity GO:0043405 120 0.757
spleen development GO:0048536 39 0.753
negative regulation of protein phosphorylation GO:0001933 126 0.753
negative regulation of t helper 2 cell differentiation GO:0045629 4 0.752
regulation of t cell activation GO:0050863 170 0.752
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.751
negative regulation of b cell mediated immunity GO:0002713 7 0.748
positive regulation of chronic inflammatory response GO:0002678 4 0.745
intrinsic apoptotic signaling pathway GO:0097193 132 0.744
antibacterial peptide production GO:0002778 2 0.740
b cell lineage commitment GO:0002326 4 0.739
positive regulation of protein modification process GO:0031401 299 0.739
negative regulation of molecular function GO:0044092 258 0.738
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.734
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.732
positive regulation of leukocyte degranulation GO:0043302 10 0.729
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.726
dephosphorylation GO:0016311 129 0.723
regulation of type ii hypersensitivity GO:0002892 4 0.721
positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 2 0.715
interleukin 12 biosynthetic process GO:0042090 8 0.714
azole transport GO:0045117 6 0.707
negative regulation of organelle organization GO:0010639 90 0.704
negative regulation of adaptive immune response GO:0002820 25 0.702
regulation of humoral immune response mediated by circulating immunoglobulin GO:0002923 10 0.701
regulation of cysteine type endopeptidase activity GO:2000116 65 0.700
apoptotic mitochondrial changes GO:0008637 48 0.698
negative regulation of interleukin 13 secretion GO:2000666 1 0.698
regulation of organelle assembly GO:1902115 19 0.695
regulation of organ morphogenesis GO:2000027 144 0.692
t cell receptor v d j recombination GO:0033153 5 0.690
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.688
positive regulation of humoral immune response GO:0002922 11 0.687
response to platelet derived growth factor GO:0036119 6 0.687
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0001844 4 0.686
positive regulation of melanocyte differentiation GO:0045636 5 0.685
regulation of odontogenesis GO:0042481 18 0.679
covalent chromatin modification GO:0016569 163 0.678
monocarboxylic acid transport GO:0015718 44 0.676
hair cycle GO:0042633 90 0.674
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.674
regulation of cytoplasmic transport GO:1903649 112 0.674
regulation of intrinsic apoptotic signaling pathway GO:2001242 61 0.672
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.671
leukocyte apoptotic process GO:0071887 71 0.669
stress activated protein kinase signaling cascade GO:0031098 81 0.668
positive regulation of interleukin 13 production GO:0032736 4 0.665
regulation of lymphocyte activation GO:0051249 240 0.664
myeloid dendritic cell activation GO:0001773 25 0.664
cytosolic calcium ion homeostasis GO:0051480 70 0.663
positive regulation of mitochondrion organization GO:0010822 17 0.661
retinal cell programmed cell death GO:0046666 8 0.659
regulation of interleukin 6 production GO:0032675 55 0.654
positive regulation of fever generation GO:0031622 6 0.651
t helper 17 cell differentiation GO:0072539 7 0.648
regulation of myeloid leukocyte differentiation GO:0002761 58 0.644
cellular divalent inorganic cation homeostasis GO:0072503 127 0.642
dna alkylation GO:0006305 43 0.637
single organism cell adhesion GO:0098602 156 0.634
regulation of reactive oxygen species metabolic process GO:2000377 40 0.633
regulation of peptidase activity GO:0052547 96 0.631
inflammatory response to antigenic stimulus GO:0002437 30 0.629
activation of innate immune response GO:0002218 56 0.628
regulation of leukocyte differentiation GO:1902105 159 0.625
regulation of chromosome organization GO:0033044 83 0.624
regulation of proteolysis GO:0030162 164 0.623
mammary gland lobule development GO:0061377 22 0.619
lymphocyte costimulation GO:0031294 15 0.619
histamine secretion by mast cell GO:0002553 1 0.618
cellular response to lipid GO:0071396 145 0.617
defense response to bacterium GO:0042742 119 0.616
calcium ion transport into cytosol GO:0060402 48 0.608
regulation of defense response to virus GO:0050688 18 0.607
immature b cell differentiation GO:0002327 10 0.606
positive regulation of translational initiation by iron GO:0045994 2 0.605
t cell apoptotic process GO:0070231 39 0.596
regulation of icosanoid secretion GO:0032303 8 0.595
cytoplasmic pattern recognition receptor signaling pathway GO:0002753 10 0.593
mapk cascade GO:0000165 281 0.591
bone resorption GO:0045453 38 0.590
cellular response to oxidative stress GO:0034599 76 0.586
negative regulation of apoptotic signaling pathway GO:2001234 104 0.585
nucleocytoplasmic transport GO:0006913 139 0.582
antimicrobial peptide biosynthetic process GO:0002777 2 0.581
regulation of t cell proliferation GO:0042129 92 0.581
divalent metal ion transport GO:0070838 172 0.577
positive regulation of apoptotic signaling pathway GO:2001235 95 0.577
protein homooligomerization GO:0051260 43 0.567
toll like receptor 4 signaling pathway GO:0034142 9 0.564
positive regulation of hydrolase activity GO:0051345 148 0.558
erk1 and erk2 cascade GO:0070371 77 0.558
isotype switching GO:0045190 36 0.552
cellular amino acid metabolic process GO:0006520 103 0.550
leukocyte homeostasis GO:0001776 79 0.549
carboxylic acid transport GO:0046942 100 0.548
positive regulation of calcium ion transport into cytosol GO:0010524 9 0.543
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.543
regulation of interleukin 6 biosynthetic process GO:0045408 11 0.542
osteoclast differentiation GO:0030316 62 0.538
cytokine secretion involved in immune response GO:0002374 6 0.535
negative regulation of protein modification process GO:0031400 163 0.534
negative regulation of intracellular signal transduction GO:1902532 167 0.534
regulation of humoral immune response GO:0002920 22 0.532
regulation of membrane potential GO:0042391 192 0.532
regulation of metal ion transport GO:0010959 106 0.530
regulation of antibacterial peptide biosynthetic process GO:0002808 1 0.528
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.525
regulation of protein homooligomerization GO:0032462 3 0.525
cytokine biosynthetic process GO:0042089 68 0.524
regulation of dendritic cell apoptotic process GO:2000668 3 0.522
regulation of adaptive immune response GO:0002819 90 0.516
response to starvation GO:0042594 65 0.507
positive regulation of calcium ion transport GO:0051928 27 0.507
cellular ketone metabolic process GO:0042180 84 0.502
regulation of mitochondrion organization GO:0010821 27 0.502
glial cell development GO:0021782 54 0.502
calcium ion homeostasis GO:0055074 127 0.498
negative regulation of protein metabolic process GO:0051248 282 0.492
negative regulation of interleukin 13 production GO:0032696 2 0.490
response to retinoic acid GO:0032526 56 0.489
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.488
multicellular organismal response to stress GO:0033555 62 0.486
negative regulation of lymphocyte proliferation GO:0050672 45 0.486
regulation of inflammatory response GO:0050727 147 0.485
regulation of type i hypersensitivity GO:0001810 4 0.481
regulation of killing of cells of other organism GO:0051709 4 0.480
cellular response to abiotic stimulus GO:0071214 56 0.480
glycerolipid metabolic process GO:0046486 122 0.474
icosanoid transport GO:0071715 14 0.473
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.468
regulation of ceramide biosynthetic process GO:2000303 1 0.466
cellular response to organonitrogen compound GO:0071417 145 0.466
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 0.460
positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 11 0.458
antibacterial humoral response GO:0019731 8 0.455
endodermal cell fate specification GO:0001714 4 0.454
mammary gland epithelial cell proliferation GO:0033598 24 0.454
mucosal associated lymphoid tissue development GO:0048537 12 0.454
regulation of nuclear division GO:0051783 56 0.453
positive regulation of b cell mediated immunity GO:0002714 26 0.448
negative regulation of lymphocyte activation GO:0051250 91 0.448
peptidyl amino acid modification GO:0018193 336 0.448
cellular response to acid chemical GO:0071229 68 0.444
cellular response to cytokine stimulus GO:0071345 189 0.443
regulation of type iia hypersensitivity GO:0001796 4 0.438
regulation of antimicrobial peptide production GO:0002784 1 0.438
regulation of neuron differentiation GO:0045664 281 0.429
negative regulation of t cell differentiation GO:0045581 23 0.428
reactive oxygen species metabolic process GO:0072593 84 0.428
protein modification by small protein conjugation or removal GO:0070647 207 0.427
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 6 0.422
cellular process regulating host cell cycle in response to virus GO:0060154 3 0.422
positive regulation of mitochondrial membrane permeability GO:0035794 12 0.421
positive regulation of map kinase activity GO:0043406 84 0.421
positive regulation of jnk cascade GO:0046330 46 0.420
developmental programmed cell death GO:0010623 41 0.419
aromatic compound catabolic process GO:0019439 286 0.418
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 19 0.417
regulation of defense response GO:0031347 233 0.413
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 0.409
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.405
cellular response to inorganic substance GO:0071241 37 0.403
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 9 0.402
response to organonitrogen compound GO:0010243 246 0.400
positive regulation of interleukin 6 production GO:0032755 37 0.400
t helper 17 type immune response GO:0072538 9 0.399
protein methylation GO:0006479 81 0.398
regionalization GO:0003002 337 0.397
negative regulation of phosphorylation GO:0042326 166 0.396
photoreceptor cell differentiation GO:0046530 52 0.395
positive regulation of interleukin 3 production GO:0032752 2 0.392
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.390
multicellular organism growth GO:0035264 161 0.387
regulation of cytokine production involved in immune response GO:0002718 26 0.387
cellular response to amino acid stimulus GO:0071230 29 0.387
dna damage checkpoint GO:0000077 26 0.382
telencephalon development GO:0021537 186 0.380
granulocyte macrophage colony stimulating factor biosynthetic process GO:0042253 2 0.380
cytoplasmic transport GO:0016482 234 0.376
hemostasis GO:0007599 78 0.374
regulation of skeletal muscle fiber development GO:0048742 36 0.373
glycolipid metabolic process GO:0006664 25 0.373
macromolecule catabolic process GO:0009057 281 0.372
intracellular receptor signaling pathway GO:0030522 74 0.370
response to organic cyclic compound GO:0014070 198 0.370
cell type specific apoptotic process GO:0097285 268 0.369
negative regulation of humoral immune response mediated by circulating immunoglobulin GO:0002924 3 0.364
icosanoid secretion GO:0032309 12 0.364
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.363
negative regulation of protein processing GO:0010955 79 0.362
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.361
mitochondrion organization GO:0007005 134 0.359
response to uv b GO:0010224 5 0.356
negative regulation of hydrolase activity GO:0051346 71 0.353
cellular response to tumor necrosis factor GO:0071356 21 0.352
epidermis development GO:0008544 187 0.352
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.350
negative regulation of gene expression epigenetic GO:0045814 15 0.348
protein acylation GO:0043543 64 0.347
cellular ion homeostasis GO:0006873 165 0.347
dna repair GO:0006281 107 0.342
extracellular matrix organization GO:0030198 147 0.337
regulation of cytokine secretion involved in immune response GO:0002739 4 0.336
g1 s transition of mitotic cell cycle GO:0000082 57 0.336
regulation of organelle organization GO:0033043 289 0.332
regulation of t helper 17 cell differentiation GO:2000319 2 0.330
neuron apoptotic process GO:0051402 142 0.327
nitrogen compound transport GO:0071705 271 0.327
salivary gland development GO:0007431 37 0.327
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.326
acid secretion GO:0046717 33 0.325
organic anion transport GO:0015711 137 0.325
negative regulation of cell proliferation GO:0008285 296 0.324
negative regulation of cysteine type endopeptidase activity GO:2000117 22 0.324
regulation of mammary gland involution GO:1903519 4 0.323
protein autophosphorylation GO:0046777 61 0.323
regulation of mast cell degranulation GO:0043304 16 0.323
regulation of mitotic cell cycle GO:0007346 126 0.320
eye photoreceptor cell differentiation GO:0001754 41 0.320
positive regulation of protein phosphorylation GO:0001934 242 0.320
positive regulation of organelle organization GO:0010638 128 0.319
positive regulation of nervous system development GO:0051962 221 0.319
production of molecular mediator of immune response GO:0002440 103 0.318
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.315
response to tumor necrosis factor GO:0034612 26 0.315
regulation of protein complex assembly GO:0043254 83 0.312
regulation of lymphocyte apoptotic process GO:0070228 41 0.311
chronic inflammatory response GO:0002544 9 0.308
regulation of defense response to virus by host GO:0050691 8 0.307
fever generation GO:0001660 7 0.302
regulation of antimicrobial humoral response GO:0002759 3 0.299
myeloid leukocyte differentiation GO:0002573 119 0.298
regulation of protein serine threonine kinase activity GO:0071900 157 0.298
cerebral cortex development GO:0021987 86 0.296
t cell mediated immunity GO:0002456 50 0.295
myeloid cell differentiation GO:0030099 233 0.294
negative regulation of regulatory t cell differentiation GO:0045590 2 0.293
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 27 0.289
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.289
regulation of histone modification GO:0031056 56 0.284
positive regulation of kinase activity GO:0033674 155 0.284
positive regulation of transferase activity GO:0051347 167 0.283
regulation of protein localization GO:0032880 231 0.282
response to hypoxia GO:0001666 58 0.282
posttranscriptional regulation of gene expression GO:0010608 155 0.282
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.281
regulation of type i interferon production GO:0032479 22 0.281
monosaccharide transport GO:0015749 58 0.276
positive regulation of cell activation GO:0050867 158 0.275
regulation of striated muscle cell differentiation GO:0051153 81 0.274
response to acid chemical GO:0001101 111 0.274
positive regulation of response to wounding GO:1903036 66 0.269
positive regulation of lymphocyte apoptotic process GO:0070230 13 0.268
negative regulation of cellular protein metabolic process GO:0032269 247 0.267
platelet aggregation GO:0070527 20 0.267
regulation of hydrolase activity GO:0051336 246 0.264
positive regulation of response to biotic stimulus GO:0002833 15 0.263
regulation of jnk cascade GO:0046328 62 0.263
epithelial tube morphogenesis GO:0060562 303 0.262
cellular response to starvation GO:0009267 57 0.262
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.261
negative regulation of cell aging GO:0090344 5 0.261
positive regulation of histone deacetylation GO:0031065 7 0.257
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.256
protein activation cascade GO:0072376 19 0.254
ensheathment of neurons GO:0007272 76 0.252
negative regulation of protein catabolic process GO:0042177 36 0.249
cellular response to nutrient levels GO:0031669 64 0.248
regulation of protein maturation GO:1903317 96 0.246
positive regulation of acute inflammatory response GO:0002675 16 0.245
positive regulation of stress activated mapk cascade GO:0032874 48 0.244
regulation of oxidative stress induced neuron intrinsic apoptotic signaling pathway GO:1903376 3 0.243
phospholipid catabolic process GO:0009395 5 0.243
regulation of innate immune response GO:0045088 91 0.243
positive regulation of proteolysis GO:0045862 85 0.242
regulation of myeloid cell differentiation GO:0045637 96 0.242
positive regulation of defense response to bacterium GO:1900426 1 0.241
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.238
protein catabolic process GO:0030163 221 0.238
positive regulation of jun kinase activity GO:0043507 30 0.236
negative regulation of odontogenesis of dentin containing tooth GO:0042489 1 0.236
regulation of multi organism process GO:0043900 111 0.234
maturation of ssu rrna GO:0030490 1 0.233
positive regulation of osteoclast differentiation GO:0045672 15 0.233
hepaticobiliary system development GO:0061008 67 0.232
odontogenesis GO:0042476 78 0.231
nuclear import GO:0051170 95 0.231
endoplasmic reticulum calcium ion homeostasis GO:0032469 11 0.229
positive regulation of translation GO:0045727 19 0.228
regulation of erythrocyte differentiation GO:0045646 23 0.227
positive regulation of lymphocyte activation GO:0051251 140 0.226
cellular response to gamma radiation GO:0071480 4 0.226

Igh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
primary immunodeficiency disease DOID:612 0 1.000
blood protein disease DOID:620 0 1.000
immune system disease DOID:2914 0 1.000
agammaglobulinemia DOID:2583 0 1.000
disease of anatomical entity DOID:7 0 1.000
common variable immunodeficiency DOID:12177 0 1.000
b cell deficiency DOID:2115 0 1.000
hematopoietic system disease DOID:74 0 1.000