Mus musculus

182 known processes

Ikzf1

IKAROS family zinc finger 1

(Aliases: 5832432G11Rik,hlk-1,LyF-1,Ikaros,mKIAA4227,Znfn1a1,KIAA4227,Zfpn1a1)

Ikzf1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of b cell differentiation GO:0045577 23 1.000
t cell differentiation in thymus GO:0033077 77 1.000
Zebrafish
lymphocyte differentiation GO:0030098 242 1.000
b cell differentiation GO:0030183 78 1.000
alpha beta t cell differentiation GO:0046632 69 1.000
b cell activation GO:0042113 161 1.000
t cell differentiation GO:0030217 174 1.000
positive regulation of gamma delta t cell differentiation GO:0045588 6 0.999
t cell activation GO:0042110 289 0.999
regulation of cell activation GO:0050865 289 0.999
t cell receptor signaling pathway GO:0050852 46 0.999
positive regulation of t cell activation GO:0050870 101 0.999
t cell selection GO:0045058 34 0.999
regulation of b cell activation GO:0050864 81 0.999
cell activation involved in immune response GO:0002263 126 0.999
cd4 positive cd25 positive alpha beta regulatory t cell differentiation GO:0002361 4 0.999
positive regulation of cell activation GO:0050867 158 0.999
leukocyte differentiation GO:0002521 342 0.999
immune response activating signal transduction GO:0002757 116 0.998
v d j recombination GO:0033151 14 0.998
somatic cell dna recombination GO:0016444 51 0.998
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.998
regulation of myeloid leukocyte differentiation GO:0002761 58 0.998
dna recombination GO:0006310 92 0.998
regulation of lymphocyte differentiation GO:0045619 107 0.998
positive regulation of t cell differentiation GO:0045582 52 0.997
t cell proliferation GO:0042098 120 0.997
negative regulation of leukocyte differentiation GO:1902106 51 0.997
positive regulation of b cell proliferation GO:0030890 24 0.997
erythrocyte differentiation GO:0030218 88 0.996
extrinsic apoptotic signaling pathway GO:0097191 126 0.996
myeloid leukocyte activation GO:0002274 83 0.996
cell fate commitment GO:0045165 210 0.996
somatic diversification of immune receptors GO:0002200 53 0.996
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 55 0.996
lymphocyte proliferation GO:0046651 164 0.995
Mouse
regulation of erythrocyte differentiation GO:0045646 23 0.995
positive regulation of regulatory t cell differentiation GO:0045591 4 0.994
positive regulation of cell development GO:0010720 237 0.994
antigen receptor mediated signaling pathway GO:0050851 64 0.994
hematopoietic stem cell migration GO:0035701 1 0.994
positive regulation of lymphocyte activation GO:0051251 140 0.993
cytokine mediated signaling pathway GO:0019221 115 0.993
regulation of leukocyte differentiation GO:1902105 159 0.993
positive regulation of translational initiation GO:0045948 4 0.992
negative regulation of myeloid leukocyte differentiation GO:0002762 20 0.992
alpha beta t cell activation GO:0046631 91 0.991
somatic diversification of immunoglobulins involved in immune response GO:0002208 36 0.989
b cell receptor signaling pathway GO:0050853 20 0.989
positive t cell selection GO:0043368 23 0.989
regulation of hypersensitivity GO:0002883 10 0.989
regulation of mast cell activation GO:0033003 21 0.987
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.986
forebrain development GO:0030900 302 0.986
myeloid cell differentiation GO:0030099 233 0.986
cytokine biosynthetic process GO:0042089 68 0.986
b cell proliferation GO:0042100 53 0.984
Mouse
immune response regulating signaling pathway GO:0002764 125 0.984
regulation of cytokine biosynthetic process GO:0042035 59 0.984
regulation of adaptive immune response GO:0002819 90 0.983
defense response to other organism GO:0098542 197 0.983
cytosolic calcium ion homeostasis GO:0051480 70 0.982
positive regulation of leukocyte differentiation GO:1902107 86 0.981
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.979
negative regulation of adaptive immune response GO:0002820 25 0.979
defense response to virus GO:0051607 68 0.977
regulation of leukocyte proliferation GO:0070663 121 0.975
Mouse
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.974
regulation of cd4 positive alpha beta t cell activation GO:2000514 24 0.973
somatic diversification of immune receptors via germline recombination within a single locus GO:0002562 51 0.972
negative regulation of cell proliferation GO:0008285 296 0.972
b cell mediated immunity GO:0019724 71 0.971
dna metabolic process GO:0006259 303 0.970
positive regulation of leukocyte proliferation GO:0070665 73 0.970
negative regulation of apoptotic signaling pathway GO:2001234 104 0.968
adaptive immune response GO:0002250 155 0.968
immature b cell differentiation GO:0002327 10 0.967
leukocyte proliferation GO:0070661 172 0.967
Mouse
regulation of leukocyte mediated immunity GO:0002703 104 0.966
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.966
myeloid leukocyte differentiation GO:0002573 119 0.966
regulation of mast cell activation involved in immune response GO:0033006 17 0.965
gland development GO:0048732 330 0.964
positive regulation of cytokine biosynthetic process GO:0042108 40 0.964
positive regulation of isotype switching to igg isotypes GO:0048304 7 0.964
b cell activation involved in immune response GO:0002312 50 0.964
activation of immune response GO:0002253 138 0.961
regulation of corticotropin releasing hormone secretion GO:0043397 2 0.959
regulation of neuron differentiation GO:0045664 281 0.959
homeostasis of number of cells GO:0048872 210 0.958
leukocyte mediated immunity GO:0002443 174 0.957
regulation of cd4 positive alpha beta t cell differentiation GO:0043370 21 0.957
myeloid cell activation involved in immune response GO:0002275 34 0.956
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 36 0.956
signal transduction in absence of ligand GO:0038034 55 0.955
t cell receptor v d j recombination GO:0033153 5 0.955
regulation of regulated secretory pathway GO:1903305 20 0.954
negative regulation of myeloid cell differentiation GO:0045638 38 0.952
immunoglobulin mediated immune response GO:0016064 69 0.952
regulation of myeloid cell differentiation GO:0045637 96 0.950
regulation of interleukin 6 production GO:0032675 55 0.950
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.950
positive regulation of myeloid cell differentiation GO:0045639 43 0.949
myeloid cell homeostasis GO:0002262 114 0.948
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.948
positive regulation of cytokine production GO:0001819 174 0.946
positive regulation of tyrosine phosphorylation of stat protein GO:0042531 15 0.946
positive regulation of nervous system development GO:0051962 221 0.946
regulation of toll like receptor signaling pathway GO:0034121 20 0.945
metal ion homeostasis GO:0055065 189 0.945
regulated secretory pathway GO:0045055 32 0.943
negative regulation of growth GO:0045926 99 0.943
apoptotic signaling pathway GO:0097190 306 0.942
leukocyte activation involved in immune response GO:0002366 126 0.940
positive regulation of adaptive immune response GO:0002821 61 0.939
cellular response to amino acid stimulus GO:0071230 29 0.934
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.933
regulation of tolerance induction dependent upon immune response GO:0002652 1 0.931
regulation of cell motility GO:2000145 236 0.931
i kappab kinase nf kappab signaling GO:0007249 85 0.929
mast cell mediated immunity GO:0002448 20 0.929
cellular response to dna damage stimulus GO:0006974 207 0.927
amine metabolic process GO:0009308 45 0.927
regulation of dendritic cell apoptotic process GO:2000668 3 0.924
lymphocyte homeostasis GO:0002260 64 0.920
negative regulation of t cell mediated cytotoxicity GO:0001915 3 0.918
regulation of binding GO:0051098 111 0.918
dendritic cell differentiation GO:0097028 26 0.916
thymic t cell selection GO:0045061 22 0.913
regulation of antimicrobial humoral response GO:0002759 3 0.913
b cell homeostasis GO:0001782 34 0.912
negative regulation of b cell activation GO:0050869 27 0.909
regulation of inflammatory response to antigenic stimulus GO:0002861 21 0.908
positive regulation of inflammatory response to antigenic stimulus GO:0002863 11 0.908
regulation of lymphocyte proliferation GO:0050670 117 0.907
Mouse
divalent metal ion transport GO:0070838 172 0.907
leukocyte homeostasis GO:0001776 79 0.905
cellular amine metabolic process GO:0044106 44 0.904
axonogenesis GO:0007409 274 0.903
single organismal cell cell adhesion GO:0016337 131 0.901
granulocyte differentiation GO:0030851 17 0.901
neutrophil differentiation GO:0030223 3 0.900
mast cell activation GO:0045576 27 0.900
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.899
positive regulation of chronic inflammatory response to antigenic stimulus GO:0002876 2 0.898
sequestering of metal ion GO:0051238 19 0.898
positive regulation of cellular amine metabolic process GO:0033240 5 0.898
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.897
erk1 and erk2 cascade GO:0070371 77 0.896
regulation of apoptotic signaling pathway GO:2001233 197 0.893
regulation of cellular amino acid metabolic process GO:0006521 5 0.893
toll like receptor 4 signaling pathway GO:0034142 9 0.892
fc receptor mediated inhibitory signaling pathway GO:0002774 1 0.891
negative regulation of homeostatic process GO:0032845 71 0.890
regulation of cytokine production GO:0001817 266 0.889
regulation of b cell proliferation GO:0030888 39 0.889
Mouse
natural killer cell differentiation GO:0001779 21 0.889
lymph node development GO:0048535 18 0.888
neuron projection guidance GO:0097485 141 0.887
mast cell activation involved in immune response GO:0002279 20 0.887
positive regulation of chronic inflammatory response GO:0002678 4 0.885
axon guidance GO:0007411 141 0.882
regulation of t cell activation GO:0050863 170 0.881
muscle fiber development GO:0048747 76 0.878
regulation of lymphocyte activation GO:0051249 240 0.877
tumor necrosis factor biosynthetic process GO:0042533 10 0.877
regulation of alpha beta t cell differentiation GO:0046637 35 0.877
regulation of extrinsic apoptotic signaling pathway GO:2001236 77 0.871
immunoglobulin secretion GO:0048305 17 0.862
regulation of neutrophil differentiation GO:0045658 2 0.862
positive regulation of tyrosine phosphorylation of stat5 protein GO:0042523 6 0.860
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.860
regulation of t cell receptor signaling pathway GO:0050856 21 0.859
cellular response to molecule of bacterial origin GO:0071219 83 0.856
negative regulation of immune system process GO:0002683 209 0.855
epithelial tube morphogenesis GO:0060562 303 0.855
somatic diversification of immunoglobulins GO:0016445 43 0.855
negative regulation of t cell mediated immunity GO:0002710 9 0.853
immune response inhibiting signal transduction GO:0002765 4 0.852
positive regulation of translational initiation by iron GO:0045994 2 0.852
regulation of epithelial cell proliferation GO:0050678 141 0.844
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.842
cd4 positive or cd8 positive alpha beta t cell lineage commitment GO:0043369 8 0.830
cellular response to cytokine stimulus GO:0071345 189 0.828
regulation of leukocyte apoptotic process GO:2000106 56 0.826
positive regulation of antigen receptor mediated signaling pathway GO:0050857 9 0.823
regulation of cellular amine metabolic process GO:0033238 20 0.821
immunoglobulin v d j recombination GO:0033152 5 0.821
positive regulation of b cell activation GO:0050871 49 0.820
negative regulation of protein modification process GO:0031400 163 0.820
positive regulation of jnk cascade GO:0046330 46 0.819
telencephalon development GO:0021537 186 0.819
maintenance of location GO:0051235 89 0.816
branching morphogenesis of an epithelial tube GO:0048754 159 0.816
myd88 independent toll like receptor signaling pathway GO:0002756 3 0.815
hematopoietic progenitor cell differentiation GO:0002244 143 0.811
inflammatory response to antigenic stimulus GO:0002437 30 0.807
myeloid leukocyte mediated immunity GO:0002444 42 0.805
thymus development GO:0048538 41 0.798
positive regulation of exocytosis GO:0045921 20 0.793
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.790
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 26 0.789
somatic recombination of immunoglobulin gene segments GO:0016447 42 0.783
negative regulation of cellular amine metabolic process GO:0033239 1 0.777
osteoclast differentiation GO:0030316 62 0.772
regulation of tumor necrosis factor production GO:0032680 49 0.770
somatic recombination of t cell receptor gene segments GO:0002681 5 0.767
single organism cell adhesion GO:0098602 156 0.763
regulation of tyrosine phosphorylation of stat5 protein GO:0042522 8 0.763
innate immune response activating signal transduction GO:0002758 50 0.762
tolerance induction to self antigen GO:0002513 4 0.761
negative regulation of molecular function GO:0044092 258 0.756
motor neuron axon guidance GO:0008045 26 0.753
calcium ion transport into cytosol GO:0060402 48 0.750
integrin mediated signaling pathway GO:0007229 27 0.750
positive regulation of growth GO:0045927 104 0.750
regulation of cellular ketone metabolic process GO:0010565 66 0.746
epithelial cell proliferation GO:0050673 174 0.745
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.745
tissue remodeling GO:0048771 102 0.742
membrane organization GO:0061024 245 0.741
lymphocyte mediated immunity GO:0002449 139 0.736
regulation of mast cell degranulation GO:0043304 16 0.735
morphogenesis of a branching epithelium GO:0061138 193 0.734
positive regulation of b cell receptor signaling pathway GO:0050861 4 0.732
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.732
defense response to bacterium GO:0042742 119 0.731
regulation of t cell differentiation GO:0045580 83 0.728
regulation of translational initiation GO:0006446 15 0.723
release of sequestered calcium ion into cytosol GO:0051209 42 0.723
isotype switching GO:0045190 36 0.722
response to organic cyclic compound GO:0014070 198 0.722
cellular metal ion homeostasis GO:0006875 151 0.721
phospholipid metabolic process GO:0006644 87 0.716
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.716
regulation of kinase activity GO:0043549 249 0.715
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.714
histamine production involved in inflammatory response GO:0002349 1 0.712
cytokine production GO:0001816 319 0.709
extracellular matrix organization GO:0030198 147 0.704
muscle cell development GO:0055001 133 0.704
covalent chromatin modification GO:0016569 163 0.701
t cell lineage commitment GO:0002360 13 0.701
mammary gland epithelial cell proliferation GO:0033598 24 0.698
negative regulation of protein metabolic process GO:0051248 282 0.698
tyrosine phosphorylation of stat protein GO:0007260 23 0.692
interleukin 12 production GO:0032615 32 0.690
regulation of cell cycle GO:0051726 281 0.689
regionalization GO:0003002 337 0.689
regulation of t cell costimulation GO:2000523 2 0.689
interleukin 6 production GO:0032635 58 0.687
positive regulation of podosome assembly GO:0071803 3 0.685
activation of cysteine type endopeptidase activity GO:0097202 27 0.685
eosinophil degranulation GO:0043308 1 0.684
bmp signaling pathway GO:0030509 93 0.683
regulation of exocytosis GO:0017157 61 0.681
negative regulation of toll like receptor signaling pathway GO:0034122 14 0.680
prostaglandin transport GO:0015732 7 0.679
sensory organ morphogenesis GO:0090596 242 0.679
regulation of skeletal muscle fiber development GO:0048742 36 0.677
osteoclast proliferation GO:0002158 4 0.677
positive regulation of lymphocyte differentiation GO:0045621 61 0.674
regulation of b cell receptor signaling pathway GO:0050855 9 0.671
extracellular structure organization GO:0043062 148 0.671
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.669
inflammatory response GO:0006954 244 0.665
cytoplasmic transport GO:0016482 234 0.660
oligodendrocyte development GO:0014003 20 0.660
odontogenesis GO:0042476 78 0.659
regulation of granulocyte differentiation GO:0030852 8 0.658
positive regulation of hematopoietic stem cell migration GO:2000473 1 0.657
regulation of map kinase activity GO:0043405 120 0.656
humoral immune response GO:0006959 57 0.653
regulation of multi organism process GO:0043900 111 0.652
cellular amino acid metabolic process GO:0006520 103 0.646
regulation of t helper 1 type immune response GO:0002825 17 0.645
positive regulation of neuron differentiation GO:0045666 141 0.645
peptidyl amino acid modification GO:0018193 336 0.643
histone modification GO:0016570 159 0.641
regulation of humoral immune response GO:0002920 22 0.639
positive regulation of leukocyte apoptotic process GO:2000108 21 0.636
olfactory bulb axon guidance GO:0071678 1 0.635
interferon gamma production GO:0032609 67 0.634
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.634
regulation of jak stat cascade GO:0046425 34 0.632
regulation of monocyte extravasation GO:2000437 2 0.629
response to ethanol GO:0045471 18 0.629
dephosphorylation GO:0016311 129 0.628
regulation of immunoglobulin mediated immune response GO:0002889 37 0.626
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.626
stem cell proliferation GO:0072089 117 0.625
cellular ion homeostasis GO:0006873 165 0.622
positive regulation of monocyte extravasation GO:2000439 1 0.618
somatic diversification of t cell receptor genes GO:0002568 5 0.617
posttranscriptional regulation of gene expression GO:0010608 155 0.617
production of molecular mediator of immune response GO:0002440 103 0.616
positive regulation of antibacterial peptide biosynthetic process GO:0006963 1 0.611
skin development GO:0043588 220 0.608
anatomical structure homeostasis GO:0060249 145 0.608
platelet aggregation GO:0070527 20 0.607
regulation of protein stability GO:0031647 52 0.607
positive regulation of cell migration GO:0030335 109 0.602
activation of cysteine type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 2 0.601
mammary gland epithelium development GO:0061180 65 0.600
t helper cell differentiation GO:0042093 28 0.600
striated muscle cell development GO:0055002 125 0.599
megakaryocyte differentiation GO:0030219 26 0.598
stem cell maintenance GO:0019827 130 0.591
negative regulation of immune effector process GO:0002698 55 0.589
morphogenesis of a branching structure GO:0001763 203 0.588
response to organonitrogen compound GO:0010243 246 0.584
detection of mechanical stimulus involved in sensory perception of pain GO:0050966 4 0.583
exocrine system development GO:0035272 45 0.582
positive regulation of mapk cascade GO:0043410 170 0.581
regulation of stress activated mapk cascade GO:0032872 69 0.581
positive regulation of erythrocyte differentiation GO:0045648 11 0.579
cellular chemical homeostasis GO:0055082 215 0.577
positive regulation of lymphocyte proliferation GO:0050671 70 0.577
muscle cell differentiation GO:0042692 261 0.577
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.574
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.572
response to lipopolysaccharide GO:0032496 128 0.568
transmission of nerve impulse GO:0019226 76 0.566
regulation of striated muscle cell differentiation GO:0051153 81 0.564
regulation of organelle organization GO:0033043 289 0.563
positive regulation of alpha beta t cell differentiation GO:0046638 28 0.562
positive regulation of stress activated mapk cascade GO:0032874 48 0.560
sphingolipid metabolic process GO:0006665 45 0.560
metanephros development GO:0001656 79 0.553
stem cell development GO:0048864 219 0.551
positive regulation of protein modification process GO:0031401 299 0.549
cd4 positive alpha beta t cell activation GO:0035710 45 0.549
multicellular organismal homeostasis GO:0048871 164 0.548
eosinophil activation GO:0043307 1 0.545
regulation of jun kinase activity GO:0043506 40 0.545
regulation of podosome assembly GO:0071801 3 0.540
myeloid dendritic cell differentiation GO:0043011 16 0.539
cytosolic calcium ion transport GO:0060401 48 0.538
angiogenesis GO:0001525 201 0.538
negative regulation of map kinase activity GO:0043407 34 0.536
actin cytoskeleton organization GO:0030036 220 0.534
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.531
regulation of ion transport GO:0043269 215 0.528
germ cell development GO:0007281 185 0.527
lymphocyte activation involved in immune response GO:0002285 93 0.526
dendritic cell apoptotic process GO:0097048 3 0.519
negative regulation of osteoblast differentiation GO:0045668 30 0.518
calcium ion homeostasis GO:0055074 127 0.516
protein localization to nucleus GO:0034504 121 0.514
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.511
regulation of interleukin 2 production GO:0032663 28 0.510
negative regulation of t helper 1 cell differentiation GO:0045626 3 0.510
gonad development GO:0008406 141 0.510
intrinsic apoptotic signaling pathway GO:0097193 132 0.507
regulation of vasculature development GO:1901342 88 0.506
calcium ion transport GO:0006816 159 0.505
regulation of chemotaxis GO:0050920 53 0.503
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.502
regulation of alpha beta t cell activation GO:0046634 53 0.502
phagocytosis GO:0006909 66 0.502
t cell differentiation involved in immune response GO:0002292 30 0.497
positive regulation of apoptotic signaling pathway GO:2001235 95 0.495
cell fate determination GO:0001709 32 0.493
negative regulation of interleukin 5 production GO:0032714 4 0.493
observational learning GO:0098597 1 0.491
positive regulation of interleukin 6 production GO:0032755 37 0.489
regulation of release of cytochrome c from mitochondria GO:0090199 11 0.487
skeletal muscle fiber development GO:0048741 58 0.485
striated muscle tissue development GO:0014706 293 0.483
b cell lineage commitment GO:0002326 4 0.482
positive regulation of myoblast differentiation GO:0045663 8 0.482
humoral immune response mediated by circulating immunoglobulin GO:0002455 14 0.480
regulation of translational initiation by iron GO:0006447 2 0.479
chemotaxis GO:0006935 247 0.479
central nervous system neuron differentiation GO:0021953 162 0.478
regulation of ion homeostasis GO:2000021 64 0.477
positive regulation of organelle organization GO:0010638 128 0.475
regulation of cellular component size GO:0032535 121 0.475
granulocyte activation GO:0036230 10 0.474
positive regulation of hypersensitivity GO:0002885 7 0.470
positive regulation of secretion by cell GO:1903532 114 0.469
regulation of defense response to virus by host GO:0050691 8 0.469
regulation of b cell apoptotic process GO:0002902 13 0.466
regulation of chronic inflammatory response GO:0002676 7 0.461
positive regulation of t cell mediated immunity GO:0002711 24 0.459
regulation of calcium ion transport into cytosol GO:0010522 31 0.459
positive regulation of osteoclast differentiation GO:0045672 15 0.457
regulation of secretion GO:0051046 274 0.454
bone resorption GO:0045453 38 0.454
carbohydrate derivative biosynthetic process GO:1901137 183 0.449
regulation of lymphocyte mediated immunity GO:0002706 84 0.447
positive regulation of mast cell degranulation GO:0043306 10 0.446
mitochondrial outer membrane permeabilization involved in programmed cell death GO:1902686 11 0.446
positive regulation of humoral immune response mediated by circulating immunoglobulin GO:0002925 6 0.445
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.443
positive regulation of interleukin 12 production GO:0032735 21 0.440
compound eye development GO:0048749 1 0.439
zymogen activation GO:0031638 41 0.439
endodermal cell fate specification GO:0001714 4 0.437
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.435
osteoclast development GO:0036035 9 0.434
positive regulation of map kinase activity GO:0043406 84 0.433
fc receptor mediated stimulatory signaling pathway GO:0002431 4 0.431
gliogenesis GO:0042063 141 0.428
learned vocalization behavior or vocal learning GO:0098598 1 0.428
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 36 0.426
hypermethylation of cpg island GO:0044027 3 0.425
regulation of regulatory t cell differentiation GO:0045589 7 0.425
muscle tissue development GO:0060537 308 0.424
cytokine production involved in immune response GO:0002367 34 0.420
positive regulation of osteoclast development GO:2001206 3 0.418
stem cell differentiation GO:0048863 268 0.418
myotube differentiation GO:0014902 105 0.417
chromatin organization GO:0006325 206 0.417
regulation of protein localization GO:0032880 231 0.416
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.416
glycoprotein metabolic process GO:0009100 116 0.415
hair follicle development GO:0001942 85 0.415
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 34 0.414
response to ionizing radiation GO:0010212 42 0.414
positive regulation of interferon gamma production GO:0032729 39 0.412
carboxylic acid transport GO:0046942 100 0.412
response to platelet derived growth factor GO:0036119 6 0.412
protection from non homologous end joining at telomere GO:0031848 4 0.407
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.404
lymphoid progenitor cell differentiation GO:0002320 17 0.403
divalent inorganic cation transport GO:0072511 178 0.401
leukocyte apoptotic process GO:0071887 71 0.400
cell maturation GO:0048469 127 0.399
platelet degranulation GO:0002576 6 0.399
translational initiation GO:0006413 24 0.398
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.398
mast cell proliferation GO:0070662 4 0.397
regulation of leukocyte degranulation GO:0043300 20 0.396
alpha beta t cell proliferation GO:0046633 21 0.396
myeloid leukocyte migration GO:0097529 57 0.396
digestive tract development GO:0048565 190 0.396
positive regulation of cysteine type endopeptidase activity GO:2001056 39 0.394
lysosome localization GO:0032418 20 0.392
negative regulation of mast cell proliferation GO:0070667 1 0.392
regulation of cell migration GO:0030334 219 0.391
male gamete generation GO:0048232 285 0.390
positive regulation of innate immune response GO:0045089 80 0.388
positive regulation of oligodendrocyte differentiation GO:0048714 9 0.388
response to dsrna GO:0043331 30 0.387
chromatin modification GO:0016568 187 0.387
oligodendrocyte differentiation GO:0048709 53 0.386
positive regulation of myeloid leukocyte mediated immunity GO:0002888 14 0.385
regulation of oligodendrocyte differentiation GO:0048713 23 0.385
salivary gland morphogenesis GO:0007435 33 0.384
tissue homeostasis GO:0001894 115 0.383
positive regulation of release of cytochrome c from mitochondria GO:0090200 5 0.382
regulation of hydrolase activity GO:0051336 246 0.379
positive regulation of phospholipase c activity GO:0010863 2 0.378
developmental maturation GO:0021700 193 0.374
nk t cell differentiation GO:0001865 8 0.373
isotype switching to igg isotypes GO:0048291 10 0.373
apical constriction GO:0003383 4 0.372
regulation of mast cell proliferation GO:0070666 4 0.372
positive regulation of gliogenesis GO:0014015 27 0.371
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.370
negative regulation of b cell mediated immunity GO:0002713 7 0.370
regulation of cysteine type endopeptidase activity GO:2000116 65 0.369
positive regulation of leukocyte mediated immunity GO:0002705 70 0.369
neuroblast fate determination GO:0007400 1 0.368
regulation of b cell mediated immunity GO:0002712 37 0.368
negative regulation of t cell activation GO:0050868 65 0.367
negative regulation of cell activation GO:0050866 111 0.366
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.365
response to molecule of bacterial origin GO:0002237 143 0.363
regulation of anatomical structure size GO:0090066 178 0.363
negative regulation of cell development GO:0010721 169 0.363
tolerance induction GO:0002507 14 0.361
gamma delta t cell differentiation GO:0042492 11 0.361
positive regulation of neuron projection development GO:0010976 79 0.359
regulation of protein serine threonine kinase activity GO:0071900 157 0.358
b cell apoptotic process GO:0001783 19 0.358
regulation of cell division GO:0051302 76 0.356
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.356

Ikzf1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.911
disease of anatomical entity DOID:7 0 0.911
myeloid leukemia DOID:8692 0 0.728
immune system cancer DOID:0060083 0 0.728
hematologic cancer DOID:2531 0 0.728
cancer DOID:162 0 0.728
leukemia DOID:1240 0 0.728
disease of cellular proliferation DOID:14566 0 0.728
organ system cancer DOID:0050686 0 0.728
disease by infectious agent DOID:0050117 0 0.609
viral infectious disease DOID:934 0 0.609
primary immunodeficiency disease DOID:612 0 0.604
blood protein disease DOID:620 0 0.580
agammaglobulinemia DOID:2583 0 0.580
common variable immunodeficiency DOID:12177 0 0.580
b cell deficiency DOID:2115 0 0.580
hematopoietic system disease DOID:74 0 0.580
human immunodeficiency virus infectious disease DOID:526 0 0.566
severe combined immunodeficiency DOID:627 0 0.436
combined t cell and b cell immunodeficiency DOID:628 0 0.436