Mus musculus

35 known processes

Il1rn

interleukin 1 receptor antagonist

(Aliases: IL-1ra,F630041P17Rik)

Il1rn biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of neutrophil mediated cytotoxicity GO:0070960 1 0.988
positive regulation of neutrophil mediated killing of symbiont cell GO:0070961 1 0.983
cytokine production GO:0001816 319 0.980
Mouse
neutrophil mediated killing of gram negative bacterium GO:0070945 4 0.970
regulation of chemokine production GO:0032642 30 0.966
Mouse
regulation of neutrophil mediated killing of gram negative bacterium GO:0070951 1 0.961
regulation of inflammatory response GO:0050727 147 0.939
Mouse
defense response to other organism GO:0098542 197 0.938
Zebrafish
defense response to bacterium GO:0042742 119 0.918
Zebrafish
response to molecule of bacterial origin GO:0002237 143 0.900
Zebrafish Mouse Rat
cellular response to lipopolysaccharide GO:0071222 77 0.894
positive regulation of defense response GO:0031349 124 0.882
Mouse
positive regulation of cytokine production GO:0001819 174 0.881
Mouse
regulation of cytokine production GO:0001817 266 0.859
Mouse
cell chemotaxis GO:0060326 81 0.845
Mouse
regulation of defense response GO:0031347 233 0.823
Mouse
chemotaxis GO:0006935 247 0.809
Mouse
inflammatory response GO:0006954 244 0.809
Human Mouse Rat
regulation of neutrophil mediated killing of fungus GO:0070953 1 0.797
regulation of cell activation GO:0050865 289 0.789
cellular response to cytokine stimulus GO:0071345 189 0.788
Human
positive regulation of natural killer cell chemotaxis GO:2000503 1 0.784
granulocyte migration GO:0097530 43 0.781
Mouse
positive regulation of hematopoietic stem cell proliferation GO:1902035 2 0.779
regulation of skeletal muscle fiber development GO:0048742 36 0.770
regulation of protein transport GO:0051223 163 0.763
regulation of innate immune response GO:0045088 91 0.763
leukocyte chemotaxis GO:0030595 69 0.762
Mouse
neutrophil migration GO:1990266 37 0.752
Mouse
positive regulation of innate immune response GO:0045089 80 0.751
regulation of neutrophil mediated killing of symbiont cell GO:0070949 2 0.746
antibacterial peptide secretion GO:0002779 1 0.746
positive regulation of neutrophil mediated killing of fungus GO:0070965 1 0.745
regulation of hematopoietic stem cell proliferation GO:1902033 3 0.726
innate immune response GO:0045087 157 0.704
positive regulation of cytokine secretion GO:0050715 41 0.691
leukocyte migration GO:0050900 124 0.686
Mouse
regulation of neutrophil mediated killing of bacterium GO:0070950 1 0.685
positive regulation of syncytium formation by plasma membrane fusion GO:0060143 17 0.683
pattern recognition receptor signaling pathway GO:0002221 47 0.681
cytokine secretion GO:0050663 72 0.652
response to lipopolysaccharide GO:0032496 128 0.644
Zebrafish Mouse Rat
leukocyte mediated immunity GO:0002443 174 0.632
metal ion homeostasis GO:0055065 189 0.621
syncytium formation by plasma membrane fusion GO:0000768 42 0.604
regulation of neutrophil mediated cytotoxicity GO:0070948 2 0.595
neutrophil mediated cytotoxicity GO:0070942 8 0.595
immune response activating signal transduction GO:0002757 116 0.592
positive regulation of killing of cells of other organism GO:0051712 3 0.587
positive regulation of cytokine biosynthetic process GO:0042108 40 0.582
Mouse
regulation of cytokine secretion GO:0050707 61 0.580
neutrophil chemotaxis GO:0030593 36 0.570
Mouse
innate immune response activating signal transduction GO:0002758 50 0.564
regulation of response to wounding GO:1903034 189 0.543
Mouse
positive regulation of cell activation GO:0050867 158 0.540
cytokine mediated signaling pathway GO:0019221 115 0.537
Human
disruption by host of symbiont cells GO:0051852 11 0.532
regulation of leukocyte proliferation GO:0070663 121 0.508
defense response to gram positive bacterium GO:0050830 50 0.506
neutrophil mediated immunity GO:0002446 19 0.502
cellular response to molecule of bacterial origin GO:0071219 83 0.501
cell killing GO:0001906 67 0.497
positive regulation of protein secretion GO:0050714 52 0.491
toll like receptor signaling pathway GO:0002224 38 0.490
activation of innate immune response GO:0002218 56 0.481
i kappab kinase nf kappab signaling GO:0007249 85 0.480
Mouse
regulation of lymphocyte activation GO:0051249 240 0.479
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.478
neutrophil mediated killing of bacterium GO:0070944 6 0.475
regulation of t cell proliferation GO:0042129 92 0.474
thymocyte migration GO:0072679 2 0.469
positive regulation of leukocyte differentiation GO:1902107 86 0.459
t cell activation GO:0042110 289 0.459
regulation of tumor necrosis factor production GO:0032680 49 0.458
regulation of defense response to bacterium GO:1900424 3 0.456
regulation of t cell activation GO:0050863 170 0.452
t cell proliferation GO:0042098 120 0.450
myeloid leukocyte migration GO:0097529 57 0.446
Mouse
regulation of protein localization GO:0032880 231 0.444
positive regulation of monocyte chemotaxis GO:0090026 2 0.437
positive regulation of neutrophil chemotaxis GO:0090023 12 0.437
macrophage chemotaxis GO:0048246 14 0.431
regulation of protein secretion GO:0050708 82 0.426
regulation of secretion GO:0051046 274 0.426
Mouse Rat
positive regulation of immune effector process GO:0002699 107 0.423
muscle fiber development GO:0048747 76 0.408
negative regulation of myotube differentiation GO:0010832 9 0.396
regulation of leukocyte mediated immunity GO:0002703 104 0.388
defense response to fungus GO:0050832 12 0.384
astrocyte cell migration GO:0043615 3 0.381
protein secretion GO:0009306 111 0.381
immune response regulating signaling pathway GO:0002764 125 0.380
regulation of killing of cells of other organism GO:0051709 4 0.380
granulocyte chemotaxis GO:0071621 39 0.379
Mouse
natural killer cell chemotaxis GO:0035747 1 0.379
antibacterial peptide biosynthetic process GO:0002780 2 0.378
cdc42 protein signal transduction GO:0032488 0 0.375
myeloid leukocyte mediated immunity GO:0002444 42 0.374
cell activation involved in immune response GO:0002263 126 0.370
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.370
detection of fungus GO:0016046 2 0.361
humoral immune response GO:0006959 57 0.357
positive regulation of macrophage chemotaxis GO:0010759 5 0.357
positive regulation of b cell chemotaxis GO:2000538 2 0.356
chemokine production GO:0032602 34 0.354
Mouse
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.352
alpha beta t cell proliferation GO:0046633 21 0.348
positive regulation of dendritic cell dendrite assembly GO:2000549 1 0.347
cation homeostasis GO:0055080 212 0.341
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.332
regulation of secretion by cell GO:1903530 249 0.332
Mouse Rat
regulation of lymphocyte proliferation GO:0050670 117 0.332
regulation of reactive oxygen species metabolic process GO:2000377 40 0.331
regulation of syncytium formation by plasma membrane fusion GO:0060142 23 0.330
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.329
mature dendritic cell differentiation GO:0097029 3 0.328
response to organic cyclic compound GO:0014070 198 0.325
Human Zebrafish Mouse Rat
dendritic cell dendrite assembly GO:0097026 2 0.321
regulation of myoblast differentiation GO:0045661 29 0.317
cation transport GO:0006812 399 0.317
regulation of defense response to fungus GO:1900150 1 0.312
regulation of natural killer cell chemotaxis GO:2000501 1 0.309
positive regulation of protein transport GO:0051222 93 0.308
negative regulation of immune system process GO:0002683 209 0.308
neutrophil mediated killing of fungus GO:0070947 3 0.307
production of molecular mediator of immune response GO:0002440 103 0.307
regulation of protein serine threonine kinase activity GO:0071900 157 0.293
Mouse Rat
regulation of toll like receptor signaling pathway GO:0034121 20 0.291
hematopoietic stem cell proliferation GO:0071425 13 0.290
positive regulation of lymphocyte proliferation GO:0050671 70 0.289
muscle cell differentiation GO:0042692 261 0.286
alpha beta t cell activation GO:0046631 91 0.286
lymphocyte proliferation GO:0046651 164 0.284
skeletal muscle fiber development GO:0048741 58 0.283
positive regulation of type 2 immune response GO:0002830 9 0.277
cellular response to peptidoglycan GO:0071224 4 0.275
inflammatory response to wounding GO:0090594 4 0.275
Mouse
regulation of cellular response to stress GO:0080135 159 0.269
Mouse Rat
regulation of establishment of protein localization GO:0070201 181 0.269
immune effector process GO:0002252 321 0.263
leukocyte proliferation GO:0070661 172 0.261
b cell chemotaxis GO:0035754 3 0.261
cellular chemical homeostasis GO:0055082 215 0.259
cytokine biosynthetic process GO:0042089 68 0.259
Mouse
macromolecule catabolic process GO:0009057 281 0.254
dendritic cell differentiation GO:0097028 26 0.247
positive regulation of t helper 1 cell differentiation GO:0045627 4 0.246
positive regulation of secretion by cell GO:1903532 114 0.245
regulation of monocyte chemotaxis GO:0090025 3 0.243
regulation of b cell chemotaxis GO:2000537 2 0.243
leukocyte activation involved in immune response GO:0002366 126 0.237
regulation of thymocyte migration GO:2000410 2 0.237
immunoglobulin production in mucosal tissue GO:0002426 3 0.230
tumor necrosis factor production GO:0032640 50 0.229
serotonin secretion by mast cell GO:0002552 1 0.227
cellular homeostasis GO:0019725 240 0.223
sequestering of metal ion GO:0051238 19 0.222
leukocyte differentiation GO:0002521 342 0.221
regulation of map kinase activity GO:0043405 120 0.220
Mouse Rat
neutrophil mediated killing of symbiont cell GO:0070943 8 0.219
interleukin 12 secretion GO:0072610 3 0.218
defense response to gram negative bacterium GO:0050829 28 0.217
positive regulation of granulocyte chemotaxis GO:0071624 12 0.215
t helper 1 cell cytokine production GO:0035744 1 0.213
killing of cells of other organism GO:0031640 13 0.213
positive regulation of macrophage activation GO:0043032 10 0.212
positive regulation of leukocyte mediated immunity GO:0002705 70 0.210
regulation of alpha beta t cell proliferation GO:0046640 18 0.209
cytosolic calcium ion homeostasis GO:0051480 70 0.209
blood vessel morphogenesis GO:0048514 285 0.208
Mouse
regulation of interleukin 6 production GO:0032675 55 0.208
Mouse
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.207
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.207
cellular calcium ion homeostasis GO:0006874 119 0.205
nucleobase containing small molecule metabolic process GO:0055086 352 0.203
regulation of cell migration GO:0030334 219 0.203
Rat
sequestering of calcium ion GO:0051208 18 0.203
positive regulation of cell motility GO:2000147 116 0.202
muscle cell development GO:0055001 133 0.201
t helper 2 cell cytokine production GO:0035745 4 0.198
positive regulation of lymphocyte activation GO:0051251 140 0.197
negative regulation of cell activation GO:0050866 111 0.194
cellular metal ion homeostasis GO:0006875 151 0.189
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.189
cd4 positive alpha beta t cell cytokine production GO:0035743 4 0.188
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.188
interaction with symbiont GO:0051702 14 0.186
adaptive immune response GO:0002250 155 0.185
regulation of alpha beta t cell activation GO:0046634 53 0.185
keratinocyte migration GO:0051546 3 0.184
killing of cells in other organism involved in symbiotic interaction GO:0051883 13 0.183
positive regulation of muscle cell differentiation GO:0051149 39 0.182
cellular response to biotic stimulus GO:0071216 92 0.181
regulation of neutrophil chemotaxis GO:0090022 14 0.180
rho protein signal transduction GO:0007266 32 0.180
positive regulation of t helper 2 cell cytokine production GO:2000553 3 0.179
jnk cascade GO:0007254 72 0.179
Mouse Rat
positive regulation of t cell differentiation GO:0045582 52 0.177
wound healing GO:0042060 157 0.177
Mouse
positive regulation of map kinase activity GO:0043406 84 0.176
Rat
regulation of myotube differentiation GO:0010830 62 0.176
positive regulation of myotube differentiation GO:0010831 24 0.175
myeloid leukocyte activation GO:0002274 83 0.175
antibacterial humoral response GO:0019731 8 0.174
myotube cell development GO:0014904 60 0.174
positive regulation of secretion GO:0051047 130 0.173
Mouse
regulation of t helper 2 cell cytokine production GO:2000551 3 0.173
regulation of immunoglobulin production in mucosal tissue GO:2000557 1 0.172
antimicrobial peptide production GO:0002775 2 0.172
positive regulation of inflammatory response GO:0050729 47 0.171
Mouse
lymphocyte differentiation GO:0030098 242 0.171
positive regulation of phagocytosis GO:0050766 26 0.169
negative regulation of macrophage chemotaxis GO:0010760 1 0.168
positive regulation of t helper 1 cell cytokine production GO:2000556 1 0.168
regulation of chemotaxis GO:0050920 53 0.167
reactive oxygen species metabolic process GO:0072593 84 0.164
nitrogen compound transport GO:0071705 271 0.164
negative regulation of cytokine production GO:0001818 84 0.163
Mouse
amine metabolic process GO:0009308 45 0.162
positive regulation of cell death GO:0010942 224 0.159
myeloid leukocyte differentiation GO:0002573 119 0.158
regulation of lymphocyte differentiation GO:0045619 107 0.156
positive regulation of immunoglobulin production in mucosal tissue GO:2000558 1 0.156
response to interleukin 1 GO:0070555 11 0.155
Human Rat
regulation of chemokine secretion GO:0090196 4 0.155
negative regulation of macrophage apoptotic process GO:2000110 3 0.155
b cell mediated immunity GO:0019724 71 0.155
cytokine metabolic process GO:0042107 71 0.154
Mouse
striated muscle tissue development GO:0014706 293 0.153
regulation of macrophage chemotaxis GO:0010758 8 0.152
cytokine production involved in immune response GO:0002367 34 0.152
regulation of t helper 1 cell cytokine production GO:2000554 1 0.151
antimicrobial peptide secretion GO:0002776 1 0.151
regulation of interferon gamma production GO:0032649 57 0.150
mature natural killer cell chemotaxis GO:0035782 1 0.150
regulation of transferase activity GO:0051338 263 0.150
Mouse Rat
leukocyte mediated cytotoxicity GO:0001909 62 0.149
response to tumor necrosis factor GO:0034612 26 0.149
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.149
modification of morphology or physiology of other organism GO:0035821 18 0.144
negative regulation of myoblast differentiation GO:0045662 18 0.143
regulation of t helper 1 cell differentiation GO:0045625 7 0.143
positive regulation of lymphocyte migration GO:2000403 11 0.142
regulation of striated muscle cell differentiation GO:0051153 81 0.141
divalent inorganic cation transport GO:0072511 178 0.138
myotube differentiation GO:0014902 105 0.136
response to organonitrogen compound GO:0010243 246 0.136
Mouse Rat
positive regulation of t cell activation GO:0050870 101 0.136
regulation of muscle tissue development GO:1901861 97 0.135
negative regulation of lipopolysaccharide mediated signaling pathway GO:0031665 3 0.132
muscle tissue development GO:0060537 308 0.131
regulation of homeostatic process GO:0032844 182 0.130
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.129
positive regulation of cell migration GO:0030335 109 0.128
cellular ion homeostasis GO:0006873 165 0.128
positive regulation of cellular amine metabolic process GO:0033240 5 0.127
negative regulation of muscle cell differentiation GO:0051148 33 0.125
superoxide anion generation GO:0042554 11 0.124
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 52 0.124
regulation of superoxide anion generation GO:0032928 4 0.124
positive regulation of lymphocyte differentiation GO:0045621 61 0.124
positive regulation of cell killing GO:0031343 33 0.124
myeloid cell activation involved in immune response GO:0002275 34 0.123
interleukin 6 production GO:0032635 58 0.122
Mouse
lipid transport GO:0006869 98 0.122
Mouse
positive regulation of myeloid leukocyte mediated immunity GO:0002888 14 0.121
peptidyl amino acid modification GO:0018193 336 0.120
positive regulation of cd4 positive alpha beta t cell proliferation GO:2000563 1 0.119
cellular response to lipid GO:0071396 145 0.118
cellular ketone metabolic process GO:0042180 84 0.117
cd4 positive alpha beta t cell differentiation GO:0043367 41 0.116
alpha beta t cell activation involved in immune response GO:0002287 31 0.116
positive regulation of eosinophil migration GO:2000418 2 0.116
positive regulation of myoblast differentiation GO:0045663 8 0.116
fat cell differentiation GO:0045444 160 0.115
positive regulation of transferase activity GO:0051347 167 0.115
Rat
nucleotide metabolic process GO:0009117 332 0.114
regulation of cell motility GO:2000145 236 0.113
Rat
purine containing compound metabolic process GO:0072521 311 0.113
regulated secretory pathway GO:0045055 32 0.113
nucleoside phosphate metabolic process GO:0006753 338 0.112
myoblast differentiation GO:0045445 52 0.111
positive regulation of striated muscle cell differentiation GO:0051155 35 0.110
negative regulation of syncytium formation by plasma membrane fusion GO:0034242 5 0.110
myeloid cell differentiation GO:0030099 233 0.109
protein catabolic process GO:0030163 221 0.108
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.106
positive regulation of chemokine production GO:0032722 22 0.106
Mouse
positive regulation of apoptotic process GO:0043065 217 0.106
regulation of cellular ketone metabolic process GO:0010565 66 0.106
t helper cell differentiation GO:0042093 28 0.106
positive regulation of mapk cascade GO:0043410 170 0.105
Mouse Rat
positive regulation of membrane protein ectodomain proteolysis GO:0051044 3 0.105
regulation of cd4 positive alpha beta t cell proliferation GO:2000561 2 0.104
cytosolic calcium ion transport GO:0060401 48 0.104
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 28 0.103
t helper 1 cell differentiation GO:0045063 13 0.103
divalent inorganic cation homeostasis GO:0072507 138 0.102
reactive nitrogen species metabolic process GO:2001057 0 0.102
positive regulation of toll like receptor 9 signaling pathway GO:0034165 2 0.102
positive regulation of protein phosphorylation GO:0001934 242 0.102
Rat
nucleoside metabolic process GO:0009116 246 0.101
glial cell differentiation GO:0010001 131 0.099
response to drug GO:0042493 75 0.099
Rat
regulation of cytokine biosynthetic process GO:0042035 59 0.099
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.098
single organism cell adhesion GO:0098602 156 0.097
Human
detection of yeast GO:0001879 2 0.096
t helper 1 type immune response GO:0042088 25 0.096
cellular amine metabolic process GO:0044106 44 0.096
heterocycle catabolic process GO:0046700 280 0.096
response to molecule of fungal origin GO:0002238 4 0.096
negative regulation of mast cell degranulation GO:0043305 4 0.095
regulation of acute inflammatory response GO:0002673 27 0.095
Mouse
cellular amino acid metabolic process GO:0006520 103 0.095
regulation of t cell differentiation GO:0045580 83 0.095
positive regulation of kinase activity GO:0033674 155 0.094
Rat
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.094
cd4 positive alpha beta t cell proliferation GO:0035739 2 0.093
homeostasis of number of cells GO:0048872 210 0.093
aromatic compound catabolic process GO:0019439 286 0.093
activation of mapk activity GO:0000187 59 0.092
calcium ion homeostasis GO:0055074 127 0.092
negative regulation of striated muscle cell differentiation GO:0051154 14 0.091
organ or tissue specific immune response GO:0002251 13 0.091
response to radiation GO:0009314 165 0.091
lymphocyte activation involved in immune response GO:0002285 93 0.090
leukocyte apoptotic process GO:0071887 71 0.090
regulation of ion transport GO:0043269 215 0.089
Mouse Rat
negative regulation of interleukin 10 secretion GO:2001180 2 0.089
exocytosis GO:0006887 121 0.089
organonitrogen compound biosynthetic process GO:1901566 192 0.088
skeletal muscle organ development GO:0060538 163 0.087
purine ribonucleoside metabolic process GO:0046128 241 0.087
regulation of t helper 1 type immune response GO:0002825 17 0.085
striated muscle cell development GO:0055002 125 0.085
positive regulation of cytokine production involved in immune response GO:0002720 19 0.085
leukocyte homeostasis GO:0001776 79 0.085
epithelial cell proliferation GO:0050673 174 0.084
interferon gamma production GO:0032609 67 0.084
antimicrobial peptide biosynthetic process GO:0002777 2 0.084
positive regulation of angiogenesis GO:0045766 46 0.083
Mouse
peptide secretion GO:0002790 114 0.083
detection of molecule of bacterial origin GO:0032490 2 0.082
peptide metabolic process GO:0006518 46 0.081
alpha beta t cell differentiation involved in immune response GO:0002293 30 0.081
antibacterial peptide production GO:0002778 2 0.081
action potential GO:0001508 78 0.081
cytoplasmic transport GO:0016482 234 0.080
regulation of b cell mediated immunity GO:0002712 37 0.080
angiogenesis GO:0001525 201 0.080
Mouse
positive regulation of thymocyte migration GO:2000412 2 0.080
purine nucleotide metabolic process GO:0006163 302 0.079
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 43 0.077
second messenger mediated signaling GO:0019932 73 0.077
positive regulation of leukocyte proliferation GO:0070665 73 0.077
i kappab phosphorylation GO:0007252 6 0.076
glycoprotein metabolic process GO:0009100 116 0.075
negative regulation of cellular component organization GO:0051129 194 0.075
organonitrogen compound catabolic process GO:1901565 264 0.075
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.075
mononuclear cell migration GO:0071674 8 0.074
t cell differentiation involved in immune response GO:0002292 30 0.074
myeloid cell apoptotic process GO:0033028 22 0.074
negative regulation of lymphocyte activation GO:0051250 91 0.073
positive regulation of interferon gamma production GO:0032729 39 0.073
t cell differentiation GO:0030217 174 0.073
t cell extravasation GO:0072683 4 0.072
positive regulation of acute inflammatory response GO:0002675 16 0.072
Mouse
membrane organization GO:0061024 245 0.072
regulation of cell killing GO:0031341 40 0.072
regulation of kinase activity GO:0043549 249 0.072
Mouse Rat
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.071
negative regulation of t cell proliferation GO:0042130 38 0.071
regulation of macrophage activation GO:0043030 17 0.071
positive regulation of macrophage derived foam cell differentiation GO:0010744 4 0.069
interleukin 12 production GO:0032615 32 0.069
negative regulation of phosphorylation GO:0042326 166 0.069
Mouse
negative regulation of protein kinase b signaling GO:0051898 18 0.069
positive regulation of t cell proliferation GO:0042102 52 0.068
glycoprotein biosynthetic process GO:0009101 89 0.068
t cell activation involved in immune response GO:0002286 43 0.068
immunoglobulin transcytosis in epithelial cells GO:0002414 2 0.068
t cell chemotaxis GO:0010818 6 0.068
positive regulation of interleukin 12 production GO:0032735 21 0.068
negative regulation of serotonin secretion GO:0014063 2 0.067
regulation of granulocyte chemotaxis GO:0071622 17 0.066
negative regulation of intracellular signal transduction GO:1902532 167 0.066
Mouse
developmental growth involved in morphogenesis GO:0060560 138 0.066
immunoglobulin mediated immune response GO:0016064 69 0.065
regulation of toll like receptor 2 signaling pathway GO:0034135 3 0.065
regulation of cellular amino acid metabolic process GO:0006521 5 0.065
inflammatory cell apoptotic process GO:0006925 11 0.064
regulation of interleukin 12 production GO:0032655 30 0.064
regulation of eosinophil migration GO:2000416 2 0.064
regulation of vascular endothelial growth factor production GO:0010574 13 0.063
Mouse
syncytium formation GO:0006949 43 0.063
ribonucleoside catabolic process GO:0042454 206 0.063
ribonucleotide metabolic process GO:0009259 291 0.063
wound healing involved in inflammatory response GO:0002246 4 0.063
Mouse
lipid localization GO:0010876 126 0.063
Mouse
regulation of nucleotide metabolic process GO:0006140 169 0.063
t cell costimulation GO:0031295 14 0.063
positive regulation of t cell migration GO:2000406 10 0.063
negative regulation of lipid metabolic process GO:0045833 30 0.062
Mouse
t cell mediated immunity GO:0002456 50 0.062
regulation of interleukin 10 secretion GO:2001179 4 0.062
positive regulation of protein kinase activity GO:0045860 144 0.062
Rat
chemokine mediated signaling pathway GO:0070098 17 0.062
extracellular matrix organization GO:0030198 147 0.062
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.061
Rat
positive regulation of intracellular transport GO:0032388 70 0.061
detection of external stimulus GO:0009581 61 0.061
carbohydrate derivative catabolic process GO:1901136 231 0.061
regulation of cell projection assembly GO:0060491 38 0.061
defense response to virus GO:0051607 68 0.061
interspecies interaction between organisms GO:0044419 83 0.060
positive regulation of t helper 1 type immune response GO:0002827 12 0.060
positive regulation of chemokine secretion GO:0090197 4 0.060
regulation of protein kinase b signaling GO:0051896 56 0.060
fat soluble vitamin biosynthetic process GO:0042362 4 0.060
calcium ion transport GO:0006816 159 0.060
negative regulation of molecular function GO:0044092 258 0.059
Human Mouse
calcium ion transport into cytosol GO:0060402 48 0.059
modification by host of symbiont morphology or physiology GO:0051851 12 0.059
regulation of vesicle mediated transport GO:0060627 139 0.059
positive regulation of stress activated mapk cascade GO:0032874 48 0.059
Mouse Rat
regulation of alpha beta t cell differentiation GO:0046637 35 0.059
carbohydrate transport GO:0008643 62 0.059
Mouse
purine nucleotide catabolic process GO:0006195 211 0.058
regulation of lymphocyte migration GO:2000401 14 0.058
disruption of cells of other organism involved in symbiotic interaction GO:0051818 13 0.058
ribose phosphate metabolic process GO:0019693 291 0.057
acute inflammatory response GO:0002526 41 0.057
Human Mouse Rat
regulation of cytokine production involved in immune response GO:0002718 26 0.057
negative regulation of cellular protein metabolic process GO:0032269 247 0.057
Mouse
regulation of dendritic cell dendrite assembly GO:2000547 2 0.057
multicellular organismal catabolic process GO:0044243 7 0.057
killing by host of symbiont cells GO:0051873 11 0.056
toll like receptor 4 signaling pathway GO:0034142 9 0.056
mast cell activation involved in immune response GO:0002279 20 0.056
cell recognition GO:0008037 83 0.056
chemokine secretion GO:0090195 5 0.056
regulation of leukocyte differentiation GO:1902105 159 0.055
regulation of hydrolase activity GO:0051336 246 0.054
interleukin 6 biosynthetic process GO:0042226 12 0.054
Mouse
positive regulation of tumor necrosis factor production GO:0032760 30 0.054
positive regulation of cholesterol storage GO:0010886 3 0.054
positive regulation of cell projection organization GO:0031346 95 0.053
negative regulation of toll like receptor 2 signaling pathway GO:0034136 3 0.053
dendritic cell chemotaxis GO:0002407 7 0.053
purine containing compound catabolic process GO:0072523 213 0.053
regulation of ion homeostasis GO:2000021 64 0.053
regulation of body fluid levels GO:0050878 162 0.052
lymphocyte chemotaxis GO:0048247 10 0.052
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.052
negative regulation of secretion GO:0051048 61 0.052
Mouse Rat
regulation of fever generation GO:0031620 6 0.052
Mouse
regulation of toll like receptor 4 signaling pathway GO:0034143 4 0.052
negative regulation of inflammatory response GO:0050728 61 0.052
antigen processing and presentation GO:0019882 47 0.052
nucleoside catabolic process GO:0009164 206 0.052
regulation of cellular response to oxidative stress GO:1900407 19 0.052
small gtpase mediated signal transduction GO:0007264 97 0.052
phagocytosis GO:0006909 66 0.051
regulation of immune complex clearance by monocytes and macrophages GO:0090264 2 0.051
release of sequestered calcium ion into cytosol GO:0051209 42 0.051
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.051
glycosyl compound metabolic process GO:1901657 246 0.050
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.049
regulation of hormone levels GO:0010817 211 0.049
t cell receptor signaling pathway GO:0050852 46 0.049
carboxylic acid transport GO:0046942 100 0.049
Mouse Rat
positive regulation of epithelial cell proliferation GO:0050679 68 0.049
maintenance of location GO:0051235 89 0.049
antimicrobial humoral response GO:0019730 11 0.049
positive regulation of neuron apoptotic process GO:0043525 25 0.049
negative regulation of cell proliferation GO:0008285 296 0.048
divalent metal ion transport GO:0070838 172 0.048
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 14 0.048
nucleoside phosphate catabolic process GO:1901292 222 0.048
glial cell apoptotic process GO:0034349 3 0.048
regulation of cellular amine metabolic process GO:0033238 20 0.048
protein kinase b signaling GO:0043491 74 0.047
regulation of fat cell differentiation GO:0045598 81 0.047
positive regulation of t helper cell differentiation GO:0045624 9 0.047
branching involved in mammary gland duct morphogenesis GO:0060444 27 0.047
adiponectin secretion GO:0070162 2 0.047
Mouse
regulation of jun kinase activity GO:0043506 40 0.047
Rat
transmission of nerve impulse GO:0019226 76 0.047
cellular divalent inorganic cation homeostasis GO:0072503 127 0.047
endocytosis GO:0006897 168 0.046
regulation of cellular component biogenesis GO:0044087 181 0.046

Il1rn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
respiratory system disease DOID:1579 0 0.138
disease of anatomical entity DOID:7 0 0.138
lower respiratory tract disease DOID:0050161 0 0.128
cancer DOID:162 0 0.070
Human
disease of cellular proliferation DOID:14566 0 0.070
Human
organ system cancer DOID:0050686 0 0.070
Human