Mus musculus

194 known processes

Irs2

insulin receptor substrate 2

(Aliases: Irs-2)

Irs2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of insulin receptor signaling pathway GO:0046626 21 0.998
positive regulation of insulin receptor signaling pathway GO:0046628 4 0.991
cellular response to peptide hormone stimulus GO:0071375 92 0.947
monosaccharide metabolic process GO:0005996 106 0.940
Human
monocarboxylic acid metabolic process GO:0032787 191 0.939
Human
male germ line stem cell asymmetric division GO:0048133 2 0.937
Fly
cellular ketone metabolic process GO:0042180 84 0.929
Human
regulation of glucan biosynthetic process GO:0010962 7 0.924
Human
carbohydrate metabolic process GO:0005975 230 0.922
Human
carbohydrate biosynthetic process GO:0016051 74 0.920
Human
regulation of cellular ketone metabolic process GO:0010565 66 0.919
Human
regulation of glucose metabolic process GO:0010906 60 0.919
Human
regulation of fatty acid metabolic process GO:0019217 28 0.916
Human
connective tissue development GO:0061448 179 0.905
regulation of fatty acid oxidation GO:0046320 10 0.901
Human
regulation of feeding behavior GO:0060259 3 0.884
cellular response to insulin stimulus GO:0032869 78 0.874
negative regulation of triglyceride metabolic process GO:0090209 4 0.867
cellular response to peptide GO:1901653 92 0.801
response to organonitrogen compound GO:0010243 246 0.799
response to peptide hormone GO:0043434 127 0.795
regulation of carbohydrate biosynthetic process GO:0043255 40 0.792
Human
negative regulation of kinase activity GO:0033673 81 0.791
multicellular organism growth GO:0035264 161 0.786
Fly
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.784
Human
glucose metabolic process GO:0006006 92 0.782
Human
polysaccharide metabolic process GO:0005976 39 0.772
Human
generation of precursor metabolites and energy GO:0006091 103 0.768
Human
insulin receptor signaling pathway GO:0008286 49 0.759
glucan biosynthetic process GO:0009250 14 0.743
Human
response to peptide GO:1901652 136 0.740
cellular response to hormone stimulus GO:0032870 150 0.712
hexose biosynthetic process GO:0019319 39 0.693
regulation of gluconeogenesis GO:0006111 30 0.691
lipid biosynthetic process GO:0008610 179 0.691
response to testosterone GO:0033574 3 0.677
regulation of cellular amine metabolic process GO:0033238 20 0.675
response to insulin GO:0032868 100 0.669
negative regulation of molecular function GO:0044092 258 0.668
glycogen biosynthetic process GO:0005978 14 0.667
Human
gluconeogenesis GO:0006094 39 0.665
neutral lipid metabolic process GO:0006638 57 0.664
cellular carbohydrate metabolic process GO:0044262 119 0.659
Human
regulation of fatty acid beta oxidation GO:0031998 1 0.611
Human
positive regulation of glucose metabolic process GO:0010907 21 0.597
Human
monosaccharide biosynthetic process GO:0046364 44 0.591
vitellogenesis GO:0007296 2 0.590
Fly
positive regulation of fatty acid oxidation GO:0046321 4 0.572
Human
positive regulation of male gonad development GO:2000020 6 0.562
regulation of cellular amino acid metabolic process GO:0006521 5 0.558
nitrogen compound transport GO:0071705 271 0.555
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.553
regulation of triglyceride metabolic process GO:0090207 17 0.550
energy reserve metabolic process GO:0006112 39 0.542
Human
mitotic cell cycle GO:0000278 195 0.539
germline stem cell asymmetric division GO:0098728 2 0.529
Fly
regulation of triglyceride biosynthetic process GO:0010866 10 0.528
regulation of protein serine threonine kinase activity GO:0071900 157 0.524
positive regulation of carbohydrate metabolic process GO:0045913 30 0.520
Human
lipid catabolic process GO:0016042 69 0.509
Human Mouse
response to organic cyclic compound GO:0014070 198 0.502
regionalization GO:0003002 337 0.501
negative regulation of cellular response to insulin stimulus GO:1900077 16 0.493
oxidation reduction process GO:0055114 342 0.493
Human
regulation of kinase activity GO:0043549 249 0.492
regulation of glycogen metabolic process GO:0070873 13 0.490
Human
regulation of lipid metabolic process GO:0019216 118 0.481
Human Mouse
spermatogenesis GO:0007283 284 0.477
Fly
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.473
negative regulation of cell proliferation GO:0008285 296 0.471
regulation of protein kinase activity GO:0045859 232 0.469
positive regulation of cellular catabolic process GO:0031331 148 0.464
Human
response to oxygen levels GO:0070482 62 0.460
Fly
cellular glucan metabolic process GO:0006073 32 0.458
Human
sterol homeostasis GO:0055092 45 0.456
organ growth GO:0035265 117 0.456
Fly
acylglycerol metabolic process GO:0006639 55 0.451
negative regulation of insulin receptor signaling pathway GO:0046627 14 0.433
cartilage development involved in endochondral bone morphogenesis GO:0060351 24 0.431
regulation of myeloid leukocyte differentiation GO:0002761 58 0.428
response to radiation GO:0009314 165 0.419
hexose metabolic process GO:0019318 98 0.418
Human
regulation of organelle organization GO:0033043 289 0.409
negative regulation of protein metabolic process GO:0051248 282 0.405
polysaccharide biosynthetic process GO:0000271 20 0.401
Human
peptidyl amino acid modification GO:0018193 336 0.398
regulation of glycogen biosynthetic process GO:0005979 7 0.393
Human
regulation of fat cell differentiation GO:0045598 81 0.391
cellular amino acid metabolic process GO:0006520 103 0.386
glucan metabolic process GO:0044042 32 0.384
Human
response to extracellular stimulus GO:0009991 127 0.379
Fly
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.377
male gamete generation GO:0048232 285 0.372
Fly
positive regulation of organelle organization GO:0010638 128 0.366
positive regulation of transferase activity GO:0051347 167 0.364
Mouse
regulation of nitrogen cycle metabolic process GO:1903314 1 0.360
positive regulation of inositol phosphate biosynthetic process GO:0060732 2 0.359
triglyceride metabolic process GO:0006641 51 0.357
carbohydrate transport GO:0008643 62 0.353
Human
female mating behavior GO:0060180 8 0.351
regulation of cell migration GO:0030334 219 0.350
regulation of neuron death GO:1901214 134 0.344
regulation of lipid catabolic process GO:0050994 15 0.343
Human
endochondral bone morphogenesis GO:0060350 50 0.342
cardiocyte differentiation GO:0035051 87 0.342
negative regulation of triglyceride biosynthetic process GO:0010868 2 0.342
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.331
negative regulation of feeding behavior GO:2000252 1 0.331
histone acetylation GO:0016573 41 0.329
erythrocyte differentiation GO:0030218 88 0.328
cell fate commitment GO:0045165 210 0.324
positive regulation of growth GO:0045927 104 0.322
Fly
positive regulation of hormone secretion GO:0046887 38 0.322
fat cell differentiation GO:0045444 160 0.317
adult behavior GO:0030534 135 0.315
germ cell development GO:0007281 185 0.308
Fly
glycerolipid metabolic process GO:0046486 122 0.307
Mouse
acylglycerol biosynthetic process GO:0046463 18 0.304
maintenance of location GO:0051235 89 0.303
regulation of binding GO:0051098 111 0.303
inflammatory response GO:0006954 244 0.300
positive regulation of cellular amine metabolic process GO:0033240 5 0.295
myeloid cell differentiation GO:0030099 233 0.290
cellular amine metabolic process GO:0044106 44 0.289
cholesterol homeostasis GO:0042632 44 0.286
steroid metabolic process GO:0008202 119 0.285
negative regulation of transferase activity GO:0051348 85 0.285
brain segmentation GO:0035284 3 0.284
regulation of circadian sleep wake cycle sleep GO:0045187 3 0.283
regulation of mapk cascade GO:0043408 248 0.283
neuron apoptotic process GO:0051402 142 0.281
endocrine system development GO:0035270 98 0.277
negative regulation of cellular carbohydrate metabolic process GO:0010677 19 0.275
ossification GO:0001503 216 0.275
axonogenesis GO:0007409 274 0.275
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.273
circadian sleep wake cycle GO:0042745 5 0.272
regulation of peptide transport GO:0090087 91 0.270
urogenital system development GO:0001655 261 0.269
regulation of cellular catabolic process GO:0031329 242 0.268
Human
muscle cell differentiation GO:0042692 261 0.268
blastocyst growth GO:0001832 23 0.268
organic acid catabolic process GO:0016054 51 0.268
Human
negative regulation of insulin secretion GO:0046676 14 0.264
negative regulation of intracellular signal transduction GO:1902532 167 0.263
developmental maturation GO:0021700 193 0.263
glycerolipid biosynthetic process GO:0045017 50 0.263
organic hydroxy compound metabolic process GO:1901615 203 0.262
regulation of circadian sleep wake cycle GO:0042749 3 0.261
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.259
Human
negative regulation of gluconeogenesis GO:0045721 9 0.258
skeletal system development GO:0001501 356 0.256
glycogen metabolic process GO:0005977 32 0.256
Human
germ line stem cell division GO:0042078 2 0.256
Fly
macroautophagy GO:0016236 21 0.255
regulation of circadian rhythm GO:0042752 58 0.254
negative regulation of cellular protein metabolic process GO:0032269 247 0.250
regulation of cellular response to insulin stimulus GO:1900076 30 0.249
circadian regulation of gene expression GO:0032922 48 0.249
development of primary female sexual characteristics GO:0046545 73 0.247
embryonic organ morphogenesis GO:0048562 276 0.245
triglyceride biosynthetic process GO:0019432 17 0.243
regulation of hormone levels GO:0010817 211 0.241
female gonad development GO:0008585 71 0.240
cellular polysaccharide metabolic process GO:0044264 38 0.238
Human
autophagy GO:0006914 45 0.238
regulation of transferase activity GO:0051338 263 0.231
cell type specific apoptotic process GO:0097285 268 0.231
amine metabolic process GO:0009308 45 0.230
neuron death GO:0070997 154 0.227
lipid modification GO:0030258 65 0.226
Human Mouse
cellular response to cytokine stimulus GO:0071345 189 0.226
regulation of intracellular transport GO:0032386 159 0.225
bone development GO:0060348 120 0.224
negative regulation of phosphorylation GO:0042326 166 0.223
regulation of androgen receptor signaling pathway GO:0060765 3 0.220
cytoplasmic transport GO:0016482 234 0.215
regulation of peptide secretion GO:0002791 77 0.215
positive regulation of mapk cascade GO:0043410 170 0.214
stem cell division GO:0017145 30 0.214
Fly
embryonic placenta development GO:0001892 98 0.212
posttranscriptional regulation of gene expression GO:0010608 155 0.211
regulation of leukocyte differentiation GO:1902105 159 0.208
organic anion transport GO:0015711 137 0.207
Human
monocarboxylic acid catabolic process GO:0072329 27 0.206
Human
negative regulation of fatty acid metabolic process GO:0045922 10 0.201
type i pneumocyte differentiation GO:0060509 7 0.199
small molecule catabolic process GO:0044282 71 0.197
Human
negative regulation of peptide secretion GO:0002792 16 0.197
regulation of translation GO:0006417 71 0.197
negative regulation of neuron death GO:1901215 98 0.194
negative regulation of neuron apoptotic process GO:0043524 92 0.193
negative regulation of fat cell differentiation GO:0045599 36 0.192
wnt signaling pathway involved in kidney development GO:0061289 2 0.192
positive regulation of protein phosphorylation GO:0001934 242 0.192
asymmetric neuroblast division GO:0055059 1 0.189
negative regulation of cellular amine metabolic process GO:0033239 1 0.186
fatty acid metabolic process GO:0006631 121 0.186
Human
response to alkaloid GO:0043279 34 0.182
cellular polysaccharide biosynthetic process GO:0033692 19 0.180
Human
transdifferentiation GO:0060290 1 0.179
neural precursor cell proliferation GO:0061351 121 0.178
mapk cascade GO:0000165 281 0.176
positive regulation of protein kinase activity GO:0045860 144 0.175
glucose import GO:0046323 32 0.173
Human
cellular response to steroid hormone stimulus GO:0071383 33 0.173
negative regulation of hydrolase activity GO:0051346 71 0.172
regulation of carbohydrate metabolic process GO:0006109 75 0.169
Human
response to purine containing compound GO:0014074 28 0.168
positive regulation of insulin secretion GO:0032024 26 0.166
negative regulation of peptide hormone secretion GO:0090278 16 0.166
regulation of cellular response to stress GO:0080135 159 0.166
negative regulation of lipid metabolic process GO:0045833 30 0.165
lipid transport GO:0006869 98 0.164
Human
negative regulation of protein phosphorylation GO:0001933 126 0.164
bile acid metabolic process GO:0008206 17 0.162
skeletal muscle cell differentiation GO:0035914 66 0.162
lipid oxidation GO:0034440 29 0.161
Human
internal protein amino acid acetylation GO:0006475 42 0.160
hindbrain development GO:0030902 128 0.160
regulation of myeloid cell differentiation GO:0045637 96 0.160
negative regulation of androgen receptor signaling pathway GO:0060766 3 0.157
lipid localization GO:0010876 126 0.154
Human
positive regulation of kinase activity GO:0033674 155 0.150
Mouse
peptidyl lysine acetylation GO:0018394 45 0.148
response to inorganic substance GO:0010035 96 0.146
inner ear morphogenesis GO:0042472 101 0.145
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 14 0.145
locomotory behavior GO:0007626 195 0.144
anion transport GO:0006820 177 0.144
Human
cellular amide metabolic process GO:0043603 58 0.144
intracellular protein transport GO:0006886 204 0.143
positive regulation of neuron differentiation GO:0045666 141 0.143
protein acylation GO:0043543 64 0.143
male meiosis i GO:0007141 16 0.142
response to nutrient levels GO:0031667 109 0.142
Fly
regulation of autophagic vacuole assembly GO:2000785 4 0.140
insulin secretion GO:0030073 89 0.139
positive regulation of cell cycle GO:0045787 92 0.139
small molecule biosynthetic process GO:0044283 132 0.139
regulation of cell cycle GO:0051726 281 0.139
cellular lipid metabolic process GO:0044255 323 0.137
Human Mouse
alpha amino acid metabolic process GO:1901605 59 0.137
negative regulation of translational initiation GO:0045947 4 0.137
peptide transport GO:0015833 133 0.137
regulation of cell motility GO:2000145 236 0.136
g protein coupled receptor signaling pathway GO:0007186 243 0.136
chromatin organization GO:0006325 206 0.135
cellular response to dna damage stimulus GO:0006974 207 0.134
sensory organ morphogenesis GO:0090596 242 0.130
response to decreased oxygen levels GO:0036293 59 0.130
Fly
appendage development GO:0048736 166 0.129
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 68 0.129
chromatin modification GO:0016568 187 0.123
cell maturation GO:0048469 127 0.123
positive regulation of fatty acid beta oxidation GO:0032000 1 0.122
Human
regulation of peptidyl lysine acetylation GO:2000756 22 0.122
olfactory learning GO:0008355 2 0.121
Fly
lactation GO:0007595 25 0.121
positive regulation of lipid metabolic process GO:0045834 40 0.121
Human Mouse
regulation of vacuole organization GO:0044088 4 0.121
neutral lipid biosynthetic process GO:0046460 18 0.120
gland development GO:0048732 330 0.118
insulin like growth factor receptor signaling pathway GO:0048009 21 0.116
regulation of response to reactive oxygen species GO:1901031 9 0.116
regulation of secretion by cell GO:1903530 249 0.115
wnt signaling pathway GO:0016055 188 0.113
anoikis GO:0043276 6 0.113
negative regulation of cell motility GO:2000146 61 0.112
negative regulation of protein modification process GO:0031400 163 0.110
associative learning GO:0008306 61 0.109
Fly
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.109
nucleocytoplasmic transport GO:0006913 139 0.106
glucose homeostasis GO:0042593 128 0.106
establishment of protein localization to organelle GO:0072594 118 0.105
lung epithelial cell differentiation GO:0060487 29 0.104
positive regulation of stem cell proliferation GO:2000648 59 0.104
regulation of activin receptor signaling pathway GO:0032925 10 0.104
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.104
Fly
negative regulation of translation GO:0017148 22 0.104
response to hypoxia GO:0001666 58 0.104
creatinine metabolic process GO:0046449 3 0.102
negative regulation of protein kinase b signaling GO:0051898 18 0.100
amide transport GO:0042886 138 0.100
histone h3 deacetylation GO:0070932 8 0.100
ear development GO:0043583 200 0.099
lung cell differentiation GO:0060479 30 0.099
regulation of polysaccharide metabolic process GO:0032881 13 0.098
Human
positive regulation of programmed cell death GO:0043068 218 0.097
regulation of hormone secretion GO:0046883 88 0.096
phosphatidylinositol mediated signaling GO:0048015 41 0.096
glucose transport GO:0015758 56 0.095
Human
regulation of glutamine family amino acid metabolic process GO:0000820 1 0.095
cartilage development GO:0051216 140 0.095
cellular chemical homeostasis GO:0055082 215 0.094
limb morphogenesis GO:0035108 149 0.094
forebrain development GO:0030900 302 0.094
epithelial tube morphogenesis GO:0060562 303 0.094
regulation of mitotic cell cycle GO:0007346 126 0.093
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 4 0.092
carbohydrate derivative biosynthetic process GO:1901137 183 0.092
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.092
heart morphogenesis GO:0003007 178 0.090
regulation of generation of precursor metabolites and energy GO:0043467 38 0.090
Human
rhythmic process GO:0048511 174 0.090
regulation of lipid biosynthetic process GO:0046890 54 0.089
epidermis development GO:0008544 187 0.088
fatty acid beta oxidation GO:0006635 16 0.088
Human
aortic valve morphogenesis GO:0003180 4 0.088
antral ovarian follicle growth GO:0001547 5 0.087
epithelial cell development GO:0002064 159 0.086
cellular response to gonadotropin stimulus GO:0071371 4 0.086
bmp signaling pathway GO:0030509 93 0.085
regulation of polysaccharide biosynthetic process GO:0032885 7 0.085
Human
cation transport GO:0006812 399 0.084
regulation of protein import into nucleus translocation GO:0033158 2 0.084
diencephalon development GO:0021536 63 0.083
organophosphate biosynthetic process GO:0090407 122 0.083
osteoclast differentiation GO:0030316 62 0.083
lymphocyte differentiation GO:0030098 242 0.083
intracellular receptor signaling pathway GO:0030522 74 0.083
positive regulation of protein modification process GO:0031401 299 0.083
organelle localization GO:0051640 179 0.081
fatty acid catabolic process GO:0009062 25 0.081
Human
fibroblast proliferation GO:0048144 35 0.081
positive regulation of peptide secretion GO:0002793 33 0.079
female sex differentiation GO:0046660 84 0.079
regulation of fibroblast proliferation GO:0048145 34 0.078
cell growth GO:0016049 130 0.078
Fly
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.078
regulation of dna binding GO:0051101 39 0.078
regulation of dna templated transcription in response to stress GO:0043620 9 0.078
nuclear transcribed mrna catabolic process deadenylation dependent decay GO:0000288 12 0.077
hormone mediated signaling pathway GO:0009755 23 0.077
regulation of peptide hormone secretion GO:0090276 75 0.077
male gonad development GO:0008584 88 0.077
negative regulation of circadian rhythm GO:0042754 8 0.077
regulation of steroid hormone biosynthetic process GO:0090030 4 0.077
t cell activation GO:0042110 289 0.077
protein autophosphorylation GO:0046777 61 0.076
inositol phosphate biosynthetic process GO:0032958 6 0.076
regulation of steroid biosynthetic process GO:0050810 26 0.075
regulation of glucagon secretion GO:0070092 2 0.075
monosaccharide transport GO:0015749 58 0.075
Human
catecholamine metabolic process GO:0006584 30 0.075
purine containing compound metabolic process GO:0072521 311 0.074
regulation of neuron projection development GO:0010975 169 0.074
developmental cell growth GO:0048588 84 0.073
Fly
peptidyl lysine modification GO:0018205 77 0.072
axon guidance GO:0007411 141 0.072
response to acid chemical GO:0001101 111 0.072
cellular response to organonitrogen compound GO:0071417 145 0.072
organonitrogen compound biosynthetic process GO:1901566 192 0.072
negative regulation of phosphorus metabolic process GO:0010563 184 0.072
cellular response to starvation GO:0009267 57 0.072
cellular response to external stimulus GO:0071496 88 0.072
synaptic transmission GO:0007268 329 0.071
autophagic vacuole assembly GO:0000045 13 0.071
positive regulation of cellular response to insulin stimulus GO:1900078 9 0.070
regulation of bmp signaling pathway GO:0030510 60 0.070
telencephalon development GO:0021537 186 0.070
regulation of glucose transport GO:0010827 32 0.070
Human
mammary gland lobule development GO:0061377 22 0.069
cell proliferation in hindbrain GO:0021534 10 0.068
succinate metabolic process GO:0006105 4 0.068
cerebellum development GO:0021549 77 0.068
regulation of fatty acid biosynthetic process GO:0042304 12 0.067
positive regulation of lipid catabolic process GO:0050996 6 0.067
Human
placenta development GO:0001890 140 0.067
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.066
energy derivation by oxidation of organic compounds GO:0015980 77 0.066
Human
circadian rhythm GO:0007623 114 0.066
striated muscle tissue development GO:0014706 293 0.066
sensory system development GO:0048880 3 0.066
negative regulation of growth GO:0045926 99 0.065
positive regulation of fibroblast proliferation GO:0048146 20 0.065
neuron projection guidance GO:0097485 141 0.065
cerebellar purkinje cell layer development GO:0021680 26 0.065
cognition GO:0050890 149 0.065
Fly
regulation of system process GO:0044057 200 0.064
b cell activation GO:0042113 161 0.064
cytokine mediated signaling pathway GO:0019221 115 0.064
regulation of exit from mitosis GO:0007096 1 0.064
b cell proliferation GO:0042100 53 0.064
positive regulation of cholesterol transport GO:0032376 9 0.064
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.063
myeloid leukocyte differentiation GO:0002573 119 0.063
acetylcholine transport GO:0015870 2 0.063
protein deacetylation GO:0006476 32 0.063
development of primary sexual characteristics GO:0045137 143 0.063
negative regulation of secretion by cell GO:1903531 54 0.063
regulation of protein transport GO:0051223 163 0.062
cellular response to oxidative stress GO:0034599 76 0.062
stem cell proliferation GO:0072089 117 0.062
positive regulation of neuron apoptotic process GO:0043525 25 0.062
positive regulation of cell death GO:0010942 224 0.062
regulation of renal sodium excretion GO:0035813 3 0.062
cellular response to metal ion GO:0071248 31 0.061
positive regulation of transcription from rna polymerase i promoter GO:0045943 3 0.061
exocrine pancreas development GO:0031017 7 0.061
jak stat cascade GO:0007259 42 0.061
cell division GO:0051301 120 0.061
Fly
regulation of endopeptidase activity GO:0052548 89 0.061
regulation of neurotransmitter uptake GO:0051580 6 0.061
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.060
positive regulation of reproductive process GO:2000243 19 0.060
regulation of mast cell differentiation GO:0060375 3 0.059
protein localization to nucleus GO:0034504 121 0.059
Mouse
negative regulation of release of cytochrome c from mitochondria GO:0090201 6 0.059
regulation of protein localization GO:0032880 231 0.059
glycoprotein metabolic process GO:0009100 116 0.059
alpha beta t cell differentiation GO:0046632 69 0.059
regulation of organ growth GO:0046620 61 0.059
Fly
positive regulation of nervous system development GO:0051962 221 0.059
regulation of male gonad development GO:2000018 7 0.059
cellular response to nutrient levels GO:0031669 64 0.059
sulfur compound biosynthetic process GO:0044272 37 0.058
regulation of inflammatory response GO:0050727 147 0.058
kidney epithelium development GO:0072073 121 0.058
regulation of cell growth GO:0001558 91 0.057
regulation of phosphate transport GO:0010966 1 0.057
bone morphogenesis GO:0060349 78 0.057
response to starvation GO:0042594 65 0.057
Fly
carboxylic acid transport GO:0046942 100 0.056
Human
regulation of b cell apoptotic process GO:0002902 13 0.056
renal sodium excretion GO:0035812 3 0.056
negative regulation of creb transcription factor activity GO:0032792 2 0.056
angiogenesis GO:0001525 201 0.056
cellular response to extracellular stimulus GO:0031668 81 0.056
lipid storage GO:0019915 36 0.056
central nervous system segmentation GO:0035283 3 0.056
positive regulation of glucose transport GO:0010828 16 0.056
Human
digestive system development GO:0055123 200 0.056
regulation of neuron apoptotic process GO:0043523 122 0.056
ammonia assimilation cycle GO:0019676 2 0.056
response to ammonium ion GO:0060359 21 0.056
glycoprotein biosynthetic process GO:0009101 89 0.055
embryonic hemopoiesis GO:0035162 23 0.055
response to amphetamine GO:0001975 16 0.055
ear morphogenesis GO:0042471 118 0.055
circulatory system process GO:0003013 197 0.055
regulation of sterol transport GO:0032371 17 0.055
organelle fission GO:0048285 170 0.054
glucose import in response to insulin stimulus GO:0044381 8 0.054
positive regulation of inositol trisphosphate biosynthetic process GO:0032962 2 0.054
vacuole organization GO:0007033 38 0.053
activin receptor signaling pathway GO:0032924 18 0.053
Fly
regulation of striated muscle cell differentiation GO:0051153 81 0.053
regulation of ion transport GO:0043269 215 0.053
Human
pancreas development GO:0031016 57 0.053
regulation of intracellular protein transport GO:0033157 82 0.053
feeding behavior GO:0007631 62 0.052
muscle tissue development GO:0060537 308 0.052
multi organism behavior GO:0051705 62 0.052
monocarboxylic acid biosynthetic process GO:0072330 61 0.052
histone h3 acetylation GO:0043966 14 0.052
segmentation GO:0035282 93 0.051
protein localization to organelle GO:0033365 185 0.051
Mouse
peptide secretion GO:0002790 114 0.051
cell fate determination GO:0001709 32 0.051
response to iron ion GO:0010039 4 0.051
cyclic purine nucleotide metabolic process GO:0052652 43 0.051
negative regulation of myeloid cell differentiation GO:0045638 38 0.051
regulation of cytoplasmic transport GO:1903649 112 0.051
cardiac muscle tissue development GO:0048738 130 0.051
regulation of inositol trisphosphate biosynthetic process GO:0032960 3 0.050
regulation of cell cycle process GO:0010564 160 0.050
regulation of b cell proliferation GO:0030888 39 0.050
macromolecule methylation GO:0043414 120 0.050
regulation of stem cell proliferation GO:0072091 78 0.050
positive regulation of sterol transport GO:0032373 9 0.050
negative regulation of phosphate metabolic process GO:0045936 184 0.050
positive regulation of smooth muscle cell migration GO:0014911 4 0.050
blastocyst development GO:0001824 80 0.049
phosphatidylinositol 3 kinase signaling GO:0014065 36 0.049
organic hydroxy compound transport GO:0015850 93 0.049
limb development GO:0060173 166 0.049
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.049
negative regulation of glycogen metabolic process GO:0070874 2 0.049
nuclear import GO:0051170 95 0.049
negative regulation of glycogen biosynthetic process GO:0045719 1 0.049
alcohol metabolic process GO:0006066 116 0.048
cholesterol transport GO:0030301 38 0.048

Irs2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.819
Human
inherited metabolic disorder DOID:655 0 0.664
diabetes mellitus DOID:9351 0 0.349
Human
type 2 diabetes mellitus DOID:9352 0 0.349
Human
carbohydrate metabolism disease DOID:0050013 0 0.349
Human
glucose metabolism disease DOID:4194 0 0.349
Human
acquired metabolic disease DOID:0060158 0 0.349
Human
spinocerebellar degeneration DOID:2478 0 0.205
spinocerebellar ataxia DOID:1441 0 0.205
central nervous system disease DOID:331 0 0.205
disease of anatomical entity DOID:7 0 0.205
neurodegenerative disease DOID:1289 0 0.205
nervous system disease DOID:863 0 0.205
carbohydrate metabolic disorder DOID:2978 0 0.073
immune system disease DOID:2914 0 0.059