Mus musculus

0 known processes

Irs3

insulin receptor substrate 3

(Aliases: AA408304,MGC106831)

Irs3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
fat cell differentiation GO:0045444 160 0.406
striated muscle tissue development GO:0014706 293 0.394
regulation of cellular amino acid metabolic process GO:0006521 5 0.333
muscle system process GO:0003012 141 0.322
cation transport GO:0006812 399 0.315
nitrogen compound transport GO:0071705 271 0.301
Mouse
cytokine production GO:0001816 319 0.291
multicellular organismal homeostasis GO:0048871 164 0.287
peptide secretion GO:0002790 114 0.276
Mouse
amine metabolic process GO:0009308 45 0.262
regulation of secretion by cell GO:1903530 249 0.250
Mouse
blood vessel morphogenesis GO:0048514 285 0.241
carbohydrate metabolic process GO:0005975 230 0.238
positive regulation of cell motility GO:2000147 116 0.237
Mouse
regulation of cell motility GO:2000145 236 0.234
Mouse
cardiac muscle tissue development GO:0048738 130 0.229
cellular ketone metabolic process GO:0042180 84 0.221
amide transport GO:0042886 138 0.211
Mouse
response to organonitrogen compound GO:0010243 246 0.207
Mouse Fly
positive regulation of secretion GO:0051047 130 0.202
Mouse
g protein coupled receptor signaling pathway GO:0007186 243 0.200
regulation of protein transport GO:0051223 163 0.193
stem cell proliferation GO:0072089 117 0.189
Mouse
regulation of protein localization GO:0032880 231 0.189
regulation of cellular ketone metabolic process GO:0010565 66 0.186
peptide transport GO:0015833 133 0.184
Mouse
locomotory behavior GO:0007626 195 0.182
forebrain development GO:0030900 302 0.176
epithelial cell proliferation GO:0050673 174 0.176
cellular amine metabolic process GO:0044106 44 0.176
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.171
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.166
Mouse Fly
astrocyte fate commitment GO:0060018 4 0.165
negative regulation of endothelial cell migration GO:0010596 4 0.159
epithelial tube morphogenesis GO:0060562 303 0.158
protein secretion GO:0009306 111 0.155
cellular amino acid metabolic process GO:0006520 103 0.151
regulation of secretion GO:0051046 274 0.149
Mouse
cation homeostasis GO:0055080 212 0.143
transmembrane transport GO:0055085 412 0.142
positive regulation of protein modification process GO:0031401 299 0.139
inflammatory response GO:0006954 244 0.137
cell type specific apoptotic process GO:0097285 268 0.131
Mouse
regulation of kinase activity GO:0043549 249 0.131
Mouse
cellular nitrogen compound catabolic process GO:0044270 280 0.130
anatomical structure homeostasis GO:0060249 145 0.130
Fly
cellular response to lipid GO:0071396 145 0.129
regulation of fat cell differentiation GO:0045598 81 0.128
negative regulation of molecular function GO:0044092 258 0.128
Mouse
regulation of cellular response to stress GO:0080135 159 0.128
peptide hormone secretion GO:0030072 109 0.125
Mouse
notch signaling pathway GO:0007219 71 0.123
regulation of hormone levels GO:0010817 211 0.123
Mouse
leukocyte differentiation GO:0002521 342 0.123
negative regulation of immune system process GO:0002683 209 0.119
organic hydroxy compound transport GO:0015850 93 0.118
regulation of cellular amine metabolic process GO:0033238 20 0.118
polarity specification of proximal distal axis GO:0010085 2 0.118
regulation of cell migration GO:0030334 219 0.117
Mouse
multicellular organismal response to stress GO:0033555 62 0.114
gland development GO:0048732 330 0.113
Mouse
cellular homeostasis GO:0019725 240 0.113
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.112
regulation of angiogenesis GO:0045765 81 0.111
positive regulation of cell development GO:0010720 237 0.110
cardiac ventricle development GO:0003231 83 0.105
cellular response to hormone stimulus GO:0032870 150 0.105
Mouse Fly
nucleoside phosphate metabolic process GO:0006753 338 0.103
regulation of response to wounding GO:1903034 189 0.101
organonitrogen compound biosynthetic process GO:1901566 192 0.101
positive regulation of cytokine production GO:0001819 174 0.101
morphogenesis of embryonic epithelium GO:0016331 159 0.100
heterocycle catabolic process GO:0046700 280 0.100
cellular carbohydrate metabolic process GO:0044262 119 0.100
mesoderm formation GO:0001707 62 0.099
circulatory system process GO:0003013 197 0.099
norepinephrine transport GO:0015874 2 0.096
purine containing compound catabolic process GO:0072523 213 0.096
small gtpase mediated signal transduction GO:0007264 97 0.096
heart morphogenesis GO:0003007 178 0.096
purine nucleotide metabolic process GO:0006163 302 0.095
cellular response to organonitrogen compound GO:0071417 145 0.095
Mouse Fly
lymphocyte differentiation GO:0030098 242 0.095
purine nucleoside metabolic process GO:0042278 241 0.094
myeloid cell differentiation GO:0030099 233 0.091
regulation of homeostatic process GO:0032844 182 0.090
negative regulation of secretion GO:0051048 61 0.090
regulation of ossification GO:0030278 112 0.089
negative regulation of neuron projection regeneration GO:0070571 3 0.089
peptidyl amino acid modification GO:0018193 336 0.088
negative regulation of blood vessel endothelial cell migration GO:0043537 3 0.088
regulation of purine nucleotide metabolic process GO:1900542 169 0.088
embryonic epithelial tube formation GO:0001838 130 0.088
limb development GO:0060173 166 0.088
ribonucleotide metabolic process GO:0009259 291 0.087
neural tube formation GO:0001841 108 0.087
tendon formation GO:0035992 4 0.087
embryonic organ morphogenesis GO:0048562 276 0.087
embryonic skeletal system morphogenesis GO:0048704 91 0.085
muscle tissue development GO:0060537 308 0.085
protein catabolic process GO:0030163 221 0.085
retina development in camera type eye GO:0060041 119 0.084
metal ion homeostasis GO:0055065 189 0.084
regulation of hydrolase activity GO:0051336 246 0.084
regulation of establishment of protein localization GO:0070201 181 0.084
neutrophil mediated killing of gram positive bacterium GO:0070946 2 0.084
positive regulation of cellular amine metabolic process GO:0033240 5 0.083
renal tubule morphogenesis GO:0061333 72 0.083
regulation of protein secretion GO:0050708 82 0.083
cognition GO:0050890 149 0.083
Fly
neural tube development GO:0021915 160 0.083
regulation of organelle organization GO:0033043 289 0.082
regulation of epithelial cell proliferation GO:0050678 141 0.082
regulation of carbohydrate metabolic process GO:0006109 75 0.082
response to lipopolysaccharide GO:0032496 128 0.082
positive regulation of cell migration GO:0030335 109 0.081
Mouse
cation transmembrane transport GO:0098655 266 0.080
regulation of cell division GO:0051302 76 0.080
ribose phosphate metabolic process GO:0019693 291 0.080
pallium development GO:0021543 120 0.078
cellular chemical homeostasis GO:0055082 215 0.078
regulation of cell cycle GO:0051726 281 0.078
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.077
carbohydrate biosynthetic process GO:0016051 74 0.076
regulation of proteolysis GO:0030162 164 0.075
response to organic cyclic compound GO:0014070 198 0.075
cellular response to glucose stimulus GO:0071333 45 0.075
regulation of membrane potential GO:0042391 192 0.075
negative regulation of secretion by cell GO:1903531 54 0.074
stem cell differentiation GO:0048863 268 0.074
immune effector process GO:0002252 321 0.074
ribonucleoside triphosphate catabolic process GO:0009203 199 0.074
trachea cartilage morphogenesis GO:0060535 4 0.074
cellular lipid metabolic process GO:0044255 323 0.074
Mouse
epithelial tube formation GO:0072175 130 0.074
cytokine secretion GO:0050663 72 0.074
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.073
positive regulation of protein secretion GO:0050714 52 0.072
ossification GO:0001503 216 0.072
purine nucleoside triphosphate metabolic process GO:0009144 226 0.071
nucleobase containing small molecule metabolic process GO:0055086 352 0.071
regulation of nucleotide metabolic process GO:0006140 169 0.071
blood circulation GO:0008015 195 0.071
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 4 0.070
generation of precursor metabolites and energy GO:0006091 103 0.070
interspecies interaction between organisms GO:0044419 83 0.070
negative regulation of neuron death GO:1901215 98 0.069
response to molecule of bacterial origin GO:0002237 143 0.069
ribose phosphate biosynthetic process GO:0046390 59 0.069
germ cell development GO:0007281 185 0.069
Fly
mitral valve development GO:0003174 4 0.068
nucleoside metabolic process GO:0009116 246 0.068
regulation of reproductive process GO:2000241 66 0.067
ureteric bud development GO:0001657 94 0.067
organophosphate biosynthetic process GO:0090407 122 0.067
nucleotide metabolic process GO:0009117 332 0.066
neuron death GO:0070997 154 0.065
regulation of endopeptidase activity GO:0052548 89 0.064
morphogenesis of a polarized epithelium GO:0001738 37 0.064
glial cell differentiation GO:0010001 131 0.064
macromolecule catabolic process GO:0009057 281 0.063
aromatic compound catabolic process GO:0019439 286 0.063
regulation of stem cell proliferation GO:0072091 78 0.062
Mouse
positive regulation of cell death GO:0010942 224 0.062
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway GO:0051482 4 0.062
tube formation GO:0035148 140 0.062
regulation of stem cell differentiation GO:2000736 50 0.062
regulation of cytokine production GO:0001817 266 0.062
response to peptide GO:1901652 136 0.062
Mouse Fly
positive regulation of protein phosphorylation GO:0001934 242 0.062
negative regulation of cellular amine metabolic process GO:0033239 1 0.062
positive regulation of nucleotide metabolic process GO:0045981 114 0.061
stem cell maintenance GO:0019827 130 0.061
mitotic cell cycle process GO:1903047 159 0.060
organic hydroxy compound metabolic process GO:1901615 203 0.060
nucleoside phosphate biosynthetic process GO:1901293 79 0.060
regulation of angiotensin metabolic process GO:0060177 4 0.060
organophosphate catabolic process GO:0046434 232 0.059
axonogenesis GO:0007409 274 0.059
positive regulation of auditory receptor cell differentiation GO:0045609 1 0.059
central nervous system neuron differentiation GO:0021953 162 0.059
regulation of retina development in camera type eye GO:1902866 3 0.059
regulation of transferase activity GO:0051338 263 0.059
Mouse
embryonic skeletal system development GO:0048706 120 0.058
positive regulation of gtpase activity GO:0043547 85 0.058
roof plate formation GO:0021509 1 0.058
male gamete generation GO:0048232 285 0.058
Fly
extracellular matrix organization GO:0030198 147 0.058
response to acid chemical GO:0001101 111 0.057
positive regulation of secretion by cell GO:1903532 114 0.057
Mouse
endomembrane system organization GO:0010256 147 0.057
regulation of cytokine secretion GO:0050707 61 0.057
myeloid leukocyte differentiation GO:0002573 119 0.056
neuromuscular process GO:0050905 99 0.056
purine nucleotide biosynthetic process GO:0006164 65 0.056
nephron epithelium development GO:0072009 92 0.056
stem cell development GO:0048864 219 0.056
negative regulation of vasculature development GO:1901343 26 0.056
circadian rhythm GO:0007623 114 0.056
somatotropin secreting cell differentiation GO:0060126 4 0.055
cellular metal ion homeostasis GO:0006875 151 0.055
guanosine containing compound catabolic process GO:1901069 144 0.055
bone mineralization GO:0030282 54 0.055
cellular response to external stimulus GO:0071496 88 0.055
carbohydrate derivative biosynthetic process GO:1901137 183 0.055
body morphogenesis GO:0010171 45 0.055
purine ribonucleoside catabolic process GO:0046130 205 0.055
ameboidal type cell migration GO:0001667 128 0.054
mesonephric duct formation GO:0072181 2 0.054
regulation of exit from mitosis GO:0007096 1 0.054
morphogenesis of a branching structure GO:0001763 203 0.054
nucleoside phosphate catabolic process GO:1901292 222 0.054
morphogenesis of a branching epithelium GO:0061138 193 0.054
apoptotic signaling pathway GO:0097190 306 0.053
bmp signaling pathway GO:0030509 93 0.053
epithelial cell morphogenesis GO:0003382 41 0.052
ion transmembrane transport GO:0034220 361 0.052
purine ribonucleotide catabolic process GO:0009154 208 0.052
tissue homeostasis GO:0001894 115 0.052
cyclic nucleotide metabolic process GO:0009187 59 0.052
cellular macromolecule catabolic process GO:0044265 206 0.052
mitochondrion organization GO:0007005 134 0.051
mitochondrial transport GO:0006839 36 0.051
regulation of neuron differentiation GO:0045664 281 0.051
negative regulation of multi organism process GO:0043901 68 0.051
mesoderm development GO:0007498 100 0.051
fatty acid biosynthetic process GO:0006633 41 0.051
appendage development GO:0048736 166 0.050
muscle cell differentiation GO:0042692 261 0.050
glucose metabolic process GO:0006006 92 0.050
cyclic purine nucleotide metabolic process GO:0052652 43 0.050
regulation of cellular catabolic process GO:0031329 242 0.050
small molecule biosynthetic process GO:0044283 132 0.050
regulation of binding GO:0051098 111 0.050
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.050
regulation of anagen GO:0051884 1 0.050
regulation of hippo signaling GO:0035330 1 0.050
regulation of cell cycle process GO:0010564 160 0.049
regulation of multi organism process GO:0043900 111 0.049
cardiac chamber development GO:0003205 108 0.049
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.049
axial mesoderm formation GO:0048320 3 0.049
regulation of neural retina development GO:0061074 3 0.048
muscle contraction GO:0006936 101 0.048
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.048
regulation of cellular component biogenesis GO:0044087 181 0.048
cyclic nucleotide biosynthetic process GO:0009190 44 0.048
positive regulation of apoptotic process GO:0043065 217 0.048
positive regulation of cell division GO:0051781 31 0.048
spermatogenesis GO:0007283 284 0.048
Fly
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.047
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.047
nephric duct formation GO:0072179 4 0.047
closure of optic fissure GO:0061386 2 0.047
guanosine containing compound metabolic process GO:1901068 144 0.047
neural precursor cell proliferation GO:0061351 121 0.047
positive regulation of ras gtpase activity GO:0032320 65 0.047
regulation of microvillus assembly GO:0032534 3 0.047
embryonic heart tube formation GO:0003144 1 0.046
regulation of osteoblast differentiation GO:0045667 67 0.046
skeletal system development GO:0001501 356 0.046
regulation of cardiac cell fate specification GO:2000043 1 0.046
purine ribonucleoside metabolic process GO:0046128 241 0.046
urogenital system development GO:0001655 261 0.046
regulation of microvillus organization GO:0032530 3 0.046
male sex differentiation GO:0046661 109 0.046
blastocyst development GO:0001824 80 0.046
calcium ion homeostasis GO:0055074 127 0.046
branching involved in ureteric bud morphogenesis GO:0001658 56 0.045
placenta development GO:0001890 140 0.045
ribonucleoside metabolic process GO:0009119 245 0.045
regulation of mast cell differentiation GO:0060375 3 0.045
cell fate specification GO:0001708 72 0.044
organelle fission GO:0048285 170 0.044
astrocyte differentiation GO:0048708 43 0.044
mapk cascade GO:0000165 281 0.044
regulation of heart rate GO:0002027 36 0.043
posttranscriptional regulation of gene expression GO:0010608 155 0.043
cell division GO:0051301 120 0.043
Fly
insulin secretion GO:0030073 89 0.043
Mouse
regulation of cysteine type endopeptidase activity GO:2000116 65 0.043
negative regulation of angiogenesis GO:0016525 25 0.042
learning or memory GO:0007611 148 0.042
Fly
divalent metal ion transport GO:0070838 172 0.042
central nervous system vasculogenesis GO:0022009 3 0.042
cellular response to peptide hormone stimulus GO:0071375 92 0.042
Mouse Fly
sensory perception GO:0007600 245 0.042
cardiac chamber morphogenesis GO:0003206 93 0.042
peptidyl tyrosine modification GO:0018212 145 0.042
axon guidance GO:0007411 141 0.042
oviduct development GO:0060066 3 0.042
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.042
regulation of neuroblast proliferation GO:1902692 27 0.042
tendon cell differentiation GO:0035990 4 0.041
monosaccharide metabolic process GO:0005996 106 0.041
auditory receptor cell fate specification GO:0042667 1 0.041
regulation of peptide hormone secretion GO:0090276 75 0.041
Mouse
rhythmic process GO:0048511 174 0.041
regulation of gtp catabolic process GO:0033124 113 0.041
ventricular cardiac muscle cell action potential GO:0086005 4 0.041
negative regulation of cell activation GO:0050866 111 0.041
negative regulation of protein metabolic process GO:0051248 282 0.041
ribonucleotide catabolic process GO:0009261 208 0.040
nucleoside triphosphate catabolic process GO:0009143 205 0.040
intracellular protein transport GO:0006886 204 0.040
adult behavior GO:0030534 135 0.040
olfactory learning GO:0008355 2 0.040
Fly
ventricular cardiac muscle tissue development GO:0003229 38 0.040
negative regulation of ossification GO:0030279 49 0.040
positive regulation of gtp catabolic process GO:0033126 85 0.040
renal vesicle induction GO:0072034 3 0.040
positive regulation of nucleotide catabolic process GO:0030813 88 0.040
aortic valve morphogenesis GO:0003180 4 0.040
positive regulation of transcription from rna polymerase ii promoter involved in norepinephrine biosynthetic process GO:2000763 1 0.039
mesonephric epithelium development GO:0072163 94 0.039
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000802 1 0.039
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.039
intestinal epithelial structure maintenance GO:0060729 4 0.039
ribonucleoside catabolic process GO:0042454 206 0.039
cellular response to prostaglandin d stimulus GO:0071799 1 0.039
camera type eye development GO:0043010 266 0.039
ventricular cardiac muscle tissue morphogenesis GO:0055010 32 0.039
somite development GO:0061053 81 0.038
carbohydrate homeostasis GO:0033500 128 0.038
regulation of system process GO:0044057 200 0.038
oxidation reduction process GO:0055114 342 0.038
neuron apoptotic process GO:0051402 142 0.038
kidney rudiment formation GO:0072003 3 0.038
positive regulation of organelle organization GO:0010638 128 0.038
norepinephrine secretion GO:0048243 2 0.038
cell proliferation involved in outflow tract morphogenesis GO:0061325 4 0.038
cellular response to monosaccharide stimulus GO:0071326 47 0.037
interleukin 8 secretion GO:0072606 3 0.037
male gonad development GO:0008584 88 0.037
glucose homeostasis GO:0042593 128 0.037
somitogenesis GO:0001756 69 0.037
camp metabolic process GO:0046058 40 0.037
regulation of mapk cascade GO:0043408 248 0.037
cardiac ventricle morphogenesis GO:0003208 50 0.037
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.037
heart contraction GO:0060047 93 0.037
adult walking behavior GO:0007628 41 0.037
regulation of purine nucleotide catabolic process GO:0033121 122 0.037
cellular response to carbohydrate stimulus GO:0071322 50 0.037
glycosyl compound metabolic process GO:1901657 246 0.037
appendage morphogenesis GO:0035107 149 0.037
lung induction GO:0060492 3 0.037
b cell activation GO:0042113 161 0.037
Mouse
carbohydrate derivative catabolic process GO:1901136 231 0.036
negative regulation of prostatic bud formation GO:0060686 4 0.036
negative regulation of cytokine production GO:0001818 84 0.036
cellular response to hexose stimulus GO:0071331 47 0.036
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 26 0.036
intrinsic apoptotic signaling pathway GO:0097193 132 0.036
regulation of leukocyte differentiation GO:1902105 159 0.036
limbic system development GO:0021761 72 0.036
epithelial cell development GO:0002064 159 0.036
regulation of auditory receptor cell differentiation GO:0045607 4 0.036
purine containing compound metabolic process GO:0072521 311 0.036
negative regulation of synapse maturation GO:2000297 2 0.036
regulation of muscle system process GO:0090257 80 0.036
positive regulation of camp mediated signaling GO:0043950 3 0.035
positive regulation of nucleoside metabolic process GO:0045979 91 0.035
organic cyclic compound catabolic process GO:1901361 295 0.035
mesoderm morphogenesis GO:0048332 64 0.035
midbrain hindbrain boundary maturation GO:0021732 1 0.035
purine containing compound biosynthetic process GO:0072522 70 0.035
purine ribonucleotide metabolic process GO:0009150 290 0.035
hemangioblast cell differentiation GO:0060217 1 0.035
nephron epithelium morphogenesis GO:0072088 68 0.035
negative regulation of growth GO:0045926 99 0.035
positive regulation of nervous system development GO:0051962 221 0.034
regulation of ras gtpase activity GO:0032318 88 0.034
dna metabolic process GO:0006259 303 0.034
regulation of endocardial cushion to mesenchymal transition involved in heart valve formation GO:2000800 1 0.034
regulation of bmp signaling pathway GO:0030510 60 0.034
peptidyl tyrosine phosphorylation GO:0018108 143 0.034
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.034
response to nutrient levels GO:0031667 109 0.033
Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.033
negative regulation of peroxisome proliferator activated receptor signaling pathway GO:0035359 3 0.033
leukocyte apoptotic process GO:0071887 71 0.033
Mouse
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.033
regulation of body fluid levels GO:0050878 162 0.033
angiogenesis GO:0001525 201 0.033
covalent chromatin modification GO:0016569 163 0.033
regulation of nucleoside metabolic process GO:0009118 130 0.033
ribonucleoside triphosphate metabolic process GO:0009199 220 0.033
positive regulation of semaphorin plexin signaling pathway involved in outflow tract morphogenesis GO:2000764 1 0.033
granzyme mediated apoptotic signaling pathway GO:0008626 1 0.033
neuron migration GO:0001764 122 0.033
spemann organizer formation at the anterior end of the primitive streak GO:0060064 1 0.033
skeletal muscle organ development GO:0060538 163 0.033
intracellular distribution of mitochondria GO:0048312 1 0.033
mesonephric duct morphogenesis GO:0072180 4 0.032
cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 3 0.032
transforming growth factor beta receptor signaling pathway involved in primitive streak formation GO:0090010 1 0.032
lymphocyte mediated immunity GO:0002449 139 0.032
cardiac right atrium morphogenesis GO:0003213 3 0.032
cytoplasmic transport GO:0016482 234 0.032
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.032
negative regulation of nervous system development GO:0051961 156 0.032
exocrine system development GO:0035272 45 0.032
pancreatic pp cell fate commitment GO:0003329 2 0.032
positive regulation of cytokine secretion GO:0050715 41 0.032
anion transport GO:0006820 177 0.032
odontogenesis of dentin containing tooth GO:0042475 66 0.032
cardiocyte differentiation GO:0035051 87 0.031
proton transport GO:0015992 35 0.031
purine nucleoside catabolic process GO:0006152 205 0.031
renal tubule development GO:0061326 87 0.031
cellular response to starvation GO:0009267 57 0.031
regulation of blood circulation GO:1903522 93 0.031
g protein coupled receptor internalization GO:0002031 3 0.031
compound eye development GO:0048749 1 0.031
second messenger mediated signaling GO:0019932 73 0.031
regulation of ureteric bud formation GO:0072106 3 0.031
nephron development GO:0072006 109 0.031
positive regulation of protein transport GO:0051222 93 0.031
mammary gland lobule development GO:0061377 22 0.030
positive regulation of fat cell differentiation GO:0045600 32 0.030
visceral serous pericardium development GO:0061032 2 0.030
kidney epithelium development GO:0072073 121 0.030
phospholipase c activating serotonin receptor signaling pathway GO:0007208 1 0.030
cellular glucose homeostasis GO:0001678 52 0.030
purine ribonucleotide biosynthetic process GO:0009152 59 0.030
monoamine transport GO:0015844 33 0.030
cellular ion homeostasis GO:0006873 165 0.030
regulation of peptide transport GO:0090087 91 0.030
Mouse
arachidonic acid metabolite production involved in inflammatory response GO:0002538 2 0.030
positive regulation of programmed cell death GO:0043068 218 0.030
kidney morphogenesis GO:0060993 83 0.030
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.030
Fly
nucleocytoplasmic transport GO:0006913 139 0.029
t cell mediated immunity GO:0002456 50 0.029
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.029
multicellular organismal signaling GO:0035637 91 0.029
cerebellum formation GO:0021588 1 0.029
glycosyl compound catabolic process GO:1901658 206 0.029
inorganic cation transmembrane transport GO:0098662 207 0.029
adaptive immune response GO:0002250 155 0.029
negative regulation of cellular protein metabolic process GO:0032269 247 0.029
endocardial cushion to mesenchymal transition involved in heart valve formation GO:0003199 4 0.029
ras protein signal transduction GO:0007265 77 0.029
regulation of cyclase activity GO:0031279 13 0.029
positive regulation of ureteric bud formation GO:0072107 3 0.029
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.029
mitral valve morphogenesis GO:0003183 4 0.029
activation of adenylate cyclase activity GO:0007190 4 0.029
sodium ion transmembrane transport GO:0035725 49 0.028
regulation of glucose metabolic process GO:0010906 60 0.028
negative regulation of cell cycle GO:0045786 123 0.028
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure GO:0002025 3 0.028
regulation of angiotensin levels in blood GO:0002002 4 0.028
heart process GO:0003015 94 0.028
positive regulation of inner ear receptor cell differentiation GO:2000982 1 0.028
regulation of kidney development GO:0090183 40 0.028
establishment of organ orientation GO:0048561 1 0.028
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.028
paraxial mesodermal cell differentiation GO:0048342 2 0.028
cellular response to steroid hormone stimulus GO:0071383 33 0.028
maintenance of location GO:0051235 89 0.028
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.028
regulation of notch signaling pathway GO:0008593 35 0.028
negative regulation of phosphate metabolic process GO:0045936 184 0.028
Mouse
nephron tubule morphogenesis GO:0072078 68 0.028
spermatid differentiation GO:0048515 115 0.027
metencephalon development GO:0022037 89 0.027
multi multicellular organism process GO:0044706 109 0.027
dentate gyrus development GO:0021542 14 0.027
negative regulation of epithelial cell proliferation GO:0050680 64 0.027
purine nucleotide catabolic process GO:0006195 211 0.027
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.027
regulation of vasculature development GO:1901342 88 0.027
nucleoside triphosphate metabolic process GO:0009141 230 0.027
peripheral nervous system development GO:0007422 53 0.027
cellular response to abiotic stimulus GO:0071214 56 0.027
ribonucleotide biosynthetic process GO:0009260 59 0.027
leukocyte mediated immunity GO:0002443 174 0.027
t cell activation involved in immune response GO:0002286 43 0.027
cell proliferation involved in heart valve development GO:2000793 2 0.027
cellular response to growth factor stimulus GO:0071363 197 0.027
regulation of mitotic cell cycle GO:0007346 126 0.027
sensory perception of pain GO:0019233 47 0.027
establishment of planar polarity involved in nephron morphogenesis GO:0072046 1 0.027
response to transforming growth factor beta GO:0071559 88 0.026
gonad development GO:0008406 141 0.026
negative regulation of insulin secretion GO:0046676 14 0.026
cell differentiation in spinal cord GO:0021515 53 0.026
regulation of chromosome organization GO:0033044 83 0.026
response to radiation GO:0009314 165 0.026
positive regulation of cellular catabolic process GO:0031331 148 0.026
multicellular organismal metabolic process GO:0044236 28 0.026
negative regulation of cell proliferation GO:0008285 296 0.026
branching morphogenesis of an epithelial tube GO:0048754 159 0.026
action potential GO:0001508 78 0.026

Irs3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.118
nervous system disease DOID:863 0 0.118
disease of metabolism DOID:0014667 0 0.046