Mus musculus

172 known processes

Kat2a

K(lysine) acetyltransferase 2A

(Aliases: AW212720,Gcn5l2,1110051E14Rik,Gcn5,mmGCN5)

Kat2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
histone h3 acetylation GO:0043966 14 1.000
histone acetylation GO:0016573 41 1.000
histone modification GO:0016570 159 0.999
covalent chromatin modification GO:0016569 163 0.999
chromatin organization GO:0006325 206 0.998
internal protein amino acid acetylation GO:0006475 42 0.994
internal peptidyl lysine acetylation GO:0018393 42 0.990
peptidyl amino acid modification GO:0018193 336 0.986
protein acylation GO:0043543 64 0.974
chromatin modification GO:0016568 187 0.973
peptidyl lysine modification GO:0018205 77 0.967
tubulin deacetylation GO:0090042 4 0.939
peptidyl lysine acetylation GO:0018394 45 0.869
regulation of protein deacetylation GO:0090311 17 0.833
positive regulation of gluconeogenesis by positive regulation of transcription from rna polymerase ii promoter GO:0035948 5 0.755
regulation of histone modification GO:0031056 56 0.689
histone h4 k16 acetylation GO:0043984 3 0.658
regulation of histone deacetylation GO:0031063 12 0.563
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 7 0.520
histone deubiquitination GO:0016578 2 0.519
Human
protein methylation GO:0006479 81 0.485
mitotic cell cycle GO:0000278 195 0.457
purine nucleoside triphosphate metabolic process GO:0009144 226 0.356
histone h4 acetylation GO:0043967 10 0.323
regulation of chromatin organization GO:1902275 57 0.317
dna metabolic process GO:0006259 303 0.304
mitotic cell cycle process GO:1903047 159 0.304
histone methylation GO:0016571 71 0.286
regulation of cell cycle phase transition GO:1901987 77 0.238
establishment of protein localization to organelle GO:0072594 118 0.235
regulation of organelle organization GO:0033043 289 0.232
regulation of chromatin modification GO:1903308 57 0.224
protein deacetylation GO:0006476 32 0.219
cell cycle checkpoint GO:0000075 47 0.217
cellular ketone metabolic process GO:0042180 84 0.201
regulation of intracellular transport GO:0032386 159 0.189
intracellular steroid hormone receptor signaling pathway GO:0030518 29 0.186
nuclear division GO:0000280 158 0.183
nuclear transport GO:0051169 139 0.181
transdifferentiation GO:0060290 1 0.181
posttranscriptional regulation of gene expression GO:0010608 155 0.176
Human
regulation of chromosome organization GO:0033044 83 0.171
skeletal system development GO:0001501 356 0.166
regulation of cytoplasmic transport GO:1903649 112 0.144
single organism nuclear import GO:1902593 95 0.143
regulation of gluconeogenesis by regulation of transcription from rna polymerase ii promoter GO:0035947 7 0.137
protein alkylation GO:0008213 81 0.133
cellular nitrogen compound catabolic process GO:0044270 280 0.130
regulation of protein import into nucleus GO:0042306 52 0.123
regulation of protein stability GO:0031647 52 0.121
Human
regulation of establishment of protein localization GO:0070201 181 0.120
protein import into nucleus GO:0006606 95 0.111
cellular amine metabolic process GO:0044106 44 0.101
regulation of protein localization GO:0032880 231 0.100
guanosine containing compound catabolic process GO:1901069 144 0.098
negative regulation of phosphorus metabolic process GO:0010563 184 0.097
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 73 0.097
ribonucleotide metabolic process GO:0009259 291 0.095
apoptotic signaling pathway GO:0097190 306 0.092
nuclear import GO:0051170 95 0.090
histone deacetylation GO:0016575 26 0.090
protein localization to organelle GO:0033365 185 0.089
negative regulation of cell cycle GO:0045786 123 0.089
Mouse
regulation of cell cycle GO:0051726 281 0.088
Mouse
protein localization to nucleus GO:0034504 121 0.085
glycosyl compound metabolic process GO:1901657 246 0.080
regulation of cellular catabolic process GO:0031329 242 0.079
embryonic organ morphogenesis GO:0048562 276 0.079
histone lysine methylation GO:0034968 50 0.079
protein targeting GO:0006605 143 0.078
regulation of nucleoside metabolic process GO:0009118 130 0.078
mitotic cell cycle checkpoint GO:0007093 31 0.077
intracellular protein transport GO:0006886 204 0.076
nucleocytoplasmic transport GO:0006913 139 0.076
skeletal system morphogenesis GO:0048705 203 0.075
regulation of purine nucleotide catabolic process GO:0033121 122 0.074
dendrite development GO:0016358 115 0.074
Fly
response to organic cyclic compound GO:0014070 198 0.073
protein modification by small protein removal GO:0070646 21 0.072
Human
development of primary sexual characteristics GO:0045137 143 0.071
regulation of nucleocytoplasmic transport GO:0046822 73 0.070
nucleotide catabolic process GO:0009166 217 0.070
methylation GO:0032259 134 0.068
gonad development GO:0008406 141 0.067
protein import GO:0017038 101 0.065
positive regulation of intracellular transport GO:0032388 70 0.064
carbohydrate derivative catabolic process GO:1901136 231 0.063
purine containing compound metabolic process GO:0072521 311 0.063
negative regulation of phosphorylation GO:0042326 166 0.063
Mouse
nucleoside phosphate metabolic process GO:0006753 338 0.060
organonitrogen compound biosynthetic process GO:1901566 192 0.059
regulation of cell cycle process GO:0010564 160 0.058
regulation of hydrolase activity GO:0051336 246 0.057
purine ribonucleoside catabolic process GO:0046130 205 0.056
cellular macromolecule catabolic process GO:0044265 206 0.055
response to reactive oxygen species GO:0000302 56 0.054
regulation of defense response to bacterium GO:1900424 3 0.053
stem cell development GO:0048864 219 0.053
macromolecule methylation GO:0043414 120 0.052
regulation of cellular amine metabolic process GO:0033238 20 0.052
organelle fission GO:0048285 170 0.051
nucleoside metabolic process GO:0009116 246 0.051
antimicrobial peptide production GO:0002775 2 0.051
positive regulation of hydrolase activity GO:0051345 148 0.048
protein modification by small protein conjugation or removal GO:0070647 207 0.048
Human
regulation of protein transport GO:0051223 163 0.048
macromolecule deacylation GO:0098732 37 0.046
regulation of mitotic cell cycle GO:0007346 126 0.046
ribonucleotide catabolic process GO:0009261 208 0.045
purine nucleoside metabolic process GO:0042278 241 0.044
negative regulation of cell cycle process GO:0010948 69 0.044
ribose phosphate metabolic process GO:0019693 291 0.044
regulation of cellular ketone metabolic process GO:0010565 66 0.044
anatomical structure homeostasis GO:0060249 145 0.042
positive regulation of apoptotic process GO:0043065 217 0.040
heterocycle catabolic process GO:0046700 280 0.040
positive regulation of gtp catabolic process GO:0033126 85 0.039
spermatogenesis GO:0007283 284 0.039
positive regulation of gtpase activity GO:0043547 85 0.039
cell division GO:0051301 120 0.038
positive regulation of programmed cell death GO:0043068 218 0.037
positive regulation of defense response to bacterium GO:1900426 1 0.037
regulation of protein targeting GO:1903533 61 0.037
nucleoside triphosphate metabolic process GO:0009141 230 0.037
rrna transcription GO:0009303 9 0.037
amine metabolic process GO:0009308 45 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.036
cellular protein catabolic process GO:0044257 155 0.036
aromatic compound catabolic process GO:0019439 286 0.036
positive regulation of nucleoside metabolic process GO:0045979 91 0.036
cell cycle g2 m phase transition GO:0044839 20 0.036
maintenance of location GO:0051235 89 0.035
cajal body organization GO:0030576 1 0.035
negative regulation of phosphate metabolic process GO:0045936 184 0.035
Mouse
ribonucleoside triphosphate catabolic process GO:0009203 199 0.035
nucleotide metabolic process GO:0009117 332 0.035
protein deubiquitination GO:0016579 19 0.034
Human
cellular carbohydrate metabolic process GO:0044262 119 0.034
regulation of purine nucleotide metabolic process GO:1900542 169 0.034
positive regulation of intracellular protein transport GO:0090316 42 0.034
regulation of protein serine threonine kinase activity GO:0071900 157 0.033
Mouse
cellular amino acid metabolic process GO:0006520 103 0.033
stem cell differentiation GO:0048863 268 0.033
carbohydrate biosynthetic process GO:0016051 74 0.033
dna integrity checkpoint GO:0031570 28 0.033
regulation of anatomical structure size GO:0090066 178 0.033
regulation of endopeptidase activity GO:0052548 89 0.033
positive regulation of growth GO:0045927 104 0.033
sensory organ morphogenesis GO:0090596 242 0.033
hexose metabolic process GO:0019318 98 0.032
intracellular receptor signaling pathway GO:0030522 74 0.032
purine containing compound catabolic process GO:0072523 213 0.032
mitotic nuclear division GO:0007067 48 0.031
organic cyclic compound catabolic process GO:1901361 295 0.031
cellular response to oxygen radical GO:0071450 14 0.030
male gamete generation GO:0048232 285 0.030
positive regulation of cellular catabolic process GO:0031331 148 0.030
regulation of intracellular protein transport GO:0033157 82 0.030
nucleoside catabolic process GO:0009164 206 0.030
leukocyte differentiation GO:0002521 342 0.029
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.029
nucleoside triphosphate catabolic process GO:0009143 205 0.028
embryonic skeletal system development GO:0048706 120 0.028
innate immune response GO:0045087 157 0.027
nucleobase containing small molecule metabolic process GO:0055086 352 0.027
positive regulation of protein modification process GO:0031401 299 0.027
gland development GO:0048732 330 0.027
rna processing GO:0006396 105 0.027
purine nucleoside triphosphate catabolic process GO:0009146 203 0.027
ribonucleoside triphosphate metabolic process GO:0009199 220 0.026
chemotaxis GO:0006935 247 0.026
mitochondrion organization GO:0007005 134 0.026
positive regulation of organelle organization GO:0010638 128 0.026
negative regulation of cell proliferation GO:0008285 296 0.026
regulation of antimicrobial humoral response GO:0002759 3 0.026
regulation of cellular amino acid metabolic process GO:0006521 5 0.026
positive regulation of gluconeogenesis GO:0045722 11 0.026
purine ribonucleotide metabolic process GO:0009150 290 0.025
microtubule based process GO:0007017 236 0.025
protein processing GO:0016485 163 0.025
guanosine containing compound metabolic process GO:1901068 144 0.025
endonucleolytic cleavage involved in rrna processing GO:0000478 1 0.025
ribonucleoside metabolic process GO:0009119 245 0.024
multicellular organismal homeostasis GO:0048871 164 0.023
positive regulation of protein phosphorylation GO:0001934 242 0.023
positive regulation of protein transport GO:0051222 93 0.023
negative regulation of apoptotic signaling pathway GO:2001234 104 0.023
macromolecule catabolic process GO:0009057 281 0.023
tissue remodeling GO:0048771 102 0.023
histone h3 k4 methylation GO:0051568 23 0.022
protein maturation GO:0051604 176 0.022
cellular response to oxidative stress GO:0034599 76 0.022
axonogenesis GO:0007409 274 0.022
Fly
response to organonitrogen compound GO:0010243 246 0.022
cellular response to external stimulus GO:0071496 88 0.022
response to temperature stimulus GO:0009266 55 0.022
regulation of protein localization to nucleus GO:1900180 60 0.022
positive regulation of chromosome segregation GO:0051984 4 0.022
response to oxidative stress GO:0006979 123 0.022
positive regulation of protein import into nucleus GO:0042307 26 0.022
negative regulation of cellular protein metabolic process GO:0032269 247 0.021
Mouse
regulation of proteolysis GO:0030162 164 0.021
cellular response to cytokine stimulus GO:0071345 189 0.021
localization within membrane GO:0051668 4 0.021
chromatin remodeling GO:0006338 32 0.021
Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.021
sensory perception GO:0007600 245 0.021
regulation of histone methylation GO:0031060 30 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.021
positive regulation of nucleotide catabolic process GO:0030813 88 0.021
negative regulation of cell cycle phase transition GO:1901988 48 0.021
post embryonic retina morphogenesis in camera type eye GO:0060060 3 0.021
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 1 0.021
regulation of mammary gland epithelial cell proliferation GO:0033599 12 0.021
regulation of organ morphogenesis GO:2000027 144 0.021
circadian regulation of gene expression GO:0032922 48 0.020
cellular response to organic cyclic compound GO:0071407 87 0.020
microtubule cytoskeleton organization GO:0000226 157 0.020
negative regulation of synapse assembly GO:0051964 3 0.020
stem cell maintenance GO:0019827 130 0.020
mammary gland epithelium development GO:0061180 65 0.020
genitalia development GO:0048806 37 0.020
response to heat GO:0009408 27 0.020
telomere maintenance GO:0000723 19 0.020
negative regulation of neuron death GO:1901215 98 0.019
epithelial cell proliferation GO:0050673 174 0.019
regulation of epithelial cell proliferation GO:0050678 141 0.019
positive regulation of antimicrobial peptide production GO:0002225 1 0.019
cytoplasmic transport GO:0016482 234 0.019
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 1 0.019
purine ribonucleotide catabolic process GO:0009154 208 0.019
blastocyst development GO:0001824 80 0.019
monosaccharide metabolic process GO:0005996 106 0.018
protein deacylation GO:0035601 36 0.018
muscle tissue development GO:0060537 308 0.018
ossification GO:0001503 216 0.018
signal transduction by p53 class mediator GO:0072331 51 0.018
purine nucleoside catabolic process GO:0006152 205 0.018
regulation of cell motility GO:2000145 236 0.018
regulation of homeostatic process GO:0032844 182 0.018
cation homeostasis GO:0055080 212 0.018
regulation of neuron death GO:1901214 134 0.018
meiosis i GO:0007127 60 0.018
dna replication independent nucleosome assembly GO:0006336 1 0.018
regulation of cytoskeleton organization GO:0051493 122 0.018
cognition GO:0050890 149 0.018
cellular response to lipid GO:0071396 145 0.017
cellular ion homeostasis GO:0006873 165 0.017
organophosphate catabolic process GO:0046434 232 0.017
symbiosis encompassing mutualism through parasitism GO:0044403 83 0.017
embryonic skeletal system morphogenesis GO:0048704 91 0.017
cellular response to dna damage stimulus GO:0006974 207 0.017
histone h3 k9 acetylation GO:0043970 5 0.017
Mouse
regulation of cellular response to stress GO:0080135 159 0.017
neuron death GO:0070997 154 0.017
monosaccharide biosynthetic process GO:0046364 44 0.017
metal ion homeostasis GO:0055065 189 0.017
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 3 0.017
cellular response to vitamin d GO:0071305 2 0.017
interspecies interaction between organisms GO:0044419 83 0.016
regulation of gtp catabolic process GO:0033124 113 0.016
regulation of cell size GO:0008361 72 0.016
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.016
proteasomal protein catabolic process GO:0010498 98 0.016
meiotic cell cycle GO:0051321 122 0.016
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.016
cellular homeostasis GO:0019725 240 0.016
purine nucleotide metabolic process GO:0006163 302 0.016
nitrogen compound transport GO:0071705 271 0.016
positive regulation of nucleotide metabolic process GO:0045981 114 0.016
regulation of apoptotic signaling pathway GO:2001233 197 0.016
small gtpase mediated signal transduction GO:0007264 97 0.016
regulation of nucleotide metabolic process GO:0006140 169 0.016
negative regulation of proteolysis GO:0045861 74 0.016
purine nucleotide catabolic process GO:0006195 211 0.016
regulation of nucleotide catabolic process GO:0030811 122 0.015
response to peptide GO:1901652 136 0.015
negative regulation of protein phosphorylation GO:0001933 126 0.015
Mouse
receptor mediated endocytosis GO:0006898 51 0.015
calcium ion homeostasis GO:0055074 127 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
regulation of transferase activity GO:0051338 263 0.015
Mouse
intrinsic apoptotic signaling pathway GO:0097193 132 0.015
gtp catabolic process GO:0006184 143 0.015
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development GO:0060528 4 0.015
cellular calcium ion homeostasis GO:0006874 119 0.015
protein catabolic process GO:0030163 221 0.015
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.015
negative regulation of molecular function GO:0044092 258 0.015
Mouse
purine ribonucleoside metabolic process GO:0046128 241 0.015
negative regulation of protein maturation GO:1903318 79 0.015
cytokine production GO:0001816 319 0.015
energy derivation by oxidation of organic compounds GO:0015980 77 0.015
dna methylation GO:0006306 43 0.015
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.015
regulation of cytokine production GO:0001817 266 0.015
synapsis GO:0007129 34 0.015
response to transforming growth factor beta GO:0071559 88 0.014
multi multicellular organism process GO:0044706 109 0.014
skin development GO:0043588 220 0.014
regulation of myeloid leukocyte differentiation GO:0002761 58 0.014
cellular response to organonitrogen compound GO:0071417 145 0.014
bone resorption GO:0045453 38 0.014
regulation of protein catabolic process GO:0042176 108 0.014
regulation of myeloid cell differentiation GO:0045637 96 0.014
striated muscle tissue development GO:0014706 293 0.014
nls bearing protein import into nucleus GO:0006607 2 0.014
positive regulation of cell death GO:0010942 224 0.014
negative regulation of kinase activity GO:0033673 81 0.014
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.014
g1 s transition of mitotic cell cycle GO:0000082 57 0.014
regulation of mitochondrion organization GO:0010821 27 0.014
regulation of cysteine type endopeptidase activity GO:2000116 65 0.014
digestive tract development GO:0048565 190 0.014
tissue homeostasis GO:0001894 115 0.014
ribonucleoside catabolic process GO:0042454 206 0.014
regulation of peptidase activity GO:0052547 96 0.014
gtp metabolic process GO:0046039 144 0.014
regulation of vitamin d receptor signaling pathway GO:0070562 2 0.013
cellular response to hormone stimulus GO:0032870 150 0.013
developmental growth involved in morphogenesis GO:0060560 138 0.013
chromatin mediated maintenance of transcription GO:0048096 2 0.013
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.013
Mouse
regulation of ras protein signal transduction GO:0046578 114 0.013
g2 m transition of mitotic cell cycle GO:0000086 20 0.013
epidermis development GO:0008544 187 0.013
rhythmic process GO:0048511 174 0.013
canonical wnt signaling pathway GO:0060070 130 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 49 0.013
positive regulation of fibroblast proliferation GO:0048146 20 0.013
negative regulation of intracellular signal transduction GO:1902532 167 0.013
nucleolus organization GO:0007000 5 0.013
cell cycle arrest GO:0007050 37 0.013
cellular response to nutrient levels GO:0031669 64 0.013
nucleus organization GO:0006997 45 0.013
primary neural tube formation GO:0014020 95 0.013
habituation GO:0046959 3 0.012
cell growth GO:0016049 130 0.012
heart process GO:0003015 94 0.012
peptidyl lysine methylation GO:0018022 29 0.012
regulation of antimicrobial peptide production GO:0002784 1 0.012
chromatin silencing GO:0006342 15 0.012
glycosyl compound catabolic process GO:1901658 206 0.012
dna damage checkpoint GO:0000077 26 0.012
circulatory system process GO:0003013 197 0.012
myeloid leukocyte differentiation GO:0002573 119 0.012
regulation of rna export from nucleus GO:0046831 4 0.012
immune effector process GO:0002252 321 0.012
mitotic g2 dna damage checkpoint GO:0007095 8 0.012
mitotic cytokinesis GO:0000281 4 0.012
rna phosphodiester bond hydrolysis GO:0090501 19 0.012
cellular response to peptide hormone stimulus GO:0071375 92 0.012
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.012
rna interference GO:0016246 2 0.011
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.011
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.011
endonucleolytic cleavage of tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000479 1 0.011
pyrimidine nucleobase metabolic process GO:0006206 3 0.011
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.011
positive regulation of antimicrobial humoral response GO:0002760 2 0.011
regulation of binding GO:0051098 111 0.011
positive regulation of protein localization to nucleus GO:1900182 30 0.011
rna 5 end processing GO:0000966 1 0.011
regulation of multi organism process GO:0043900 111 0.011
regulation of map kinase activity GO:0043405 120 0.011
cellular response to alcohol GO:0097306 23 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 147 0.011
regulation of g protein coupled receptor protein signaling pathway GO:0008277 37 0.011
transmembrane transport GO:0055085 412 0.011
phagocytosis GO:0006909 66 0.011
hatching GO:0035188 4 0.011
neural tube development GO:0021915 160 0.011
regulation of kinase activity GO:0043549 249 0.011
Mouse
chromosome organization involved in meiosis GO:0070192 39 0.011
mitochondrion transport along microtubule GO:0047497 3 0.010
regulation of protein kinase activity GO:0045859 232 0.010
Mouse
carbohydrate derivative biosynthetic process GO:1901137 183 0.010
regulation of glucose metabolic process GO:0010906 60 0.010
mapk cascade GO:0000165 281 0.010
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.010
neural retina development GO:0003407 41 0.010
atp metabolic process GO:0046034 75 0.010
regulation of ossification GO:0030278 112 0.010
cell cycle g1 s phase transition GO:0044843 57 0.010
hexose biosynthetic process GO:0019319 39 0.010

Kat2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.015
gastrointestinal system cancer DOID:3119 0 0.012
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
retinal disease DOID:5679 0 0.012
retinal degeneration DOID:8466 0 0.012
sensory system disease DOID:0050155 0 0.012
disease of anatomical entity DOID:7 0 0.012
eye and adnexa disease DOID:1492 0 0.012
nervous system disease DOID:863 0 0.012
eye disease DOID:5614 0 0.012
large intestine cancer DOID:5672 0 0.011
intestinal cancer DOID:10155 0 0.011