Mus musculus

202 known processes

Kdr

kinase insert domain protein receptor

(Aliases: Flk1,Flk-1,VEGFR2,6130401C07,VEGFR-2,sVEGFR-2,Ly73,Krd-1)

Kdr biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
metanephric glomerular mesangium development GO:0072223 3 1.000
Mouse
metanephric glomerular mesangial cell proliferation involved in metanephros development GO:0072262 3 0.998
Mouse
regulation of vasculogenesis GO:2001212 9 0.998
positive regulation of smooth muscle cell migration GO:0014911 4 0.995
Mouse
positive regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:0035793 1 0.994
Mouse
kidney vasculature development GO:0061440 15 0.994
Mouse
cell migration involved in coronary angiogenesis GO:0060981 1 0.993
Mouse
response to macrophage colony stimulating factor GO:0036005 3 0.990
Mouse
dendritic cell cytokine production GO:0002371 3 0.988
Mouse
melanocyte migration GO:0097324 2 0.987
Mouse
metanephric glomerulus vasculature morphogenesis GO:0072276 3 0.987
Mouse
vascular endothelial growth factor signaling pathway GO:0038084 10 0.983
heart trabecula formation GO:0060347 14 0.982
vegf activated neuropilin signaling pathway GO:0038190 2 0.979
regulation of metanephric mesenchymal cell migration by platelet derived growth factor receptor beta signaling pathway GO:1900238 1 0.976
Mouse
cellular response to erythropoietin GO:0036018 1 0.975
Mouse
metanephric mesenchymal cell migration GO:0035789 2 0.972
Mouse
retina vasculature development in camera type eye GO:0061298 17 0.966
Mouse
cell migration involved in vasculogenesis GO:0035441 2 0.964
Mouse
regulation of smooth muscle cell migration GO:0014910 6 0.964
Mouse
regulation of b cell differentiation GO:0045577 23 0.963
Mouse
metanephric glomerulus morphogenesis GO:0072275 3 0.961
Mouse
cellular response to vascular endothelial growth factor stimulus GO:0035924 11 0.960
regulation of angiogenesis GO:0045765 81 0.958
pro t cell differentiation GO:0002572 3 0.957
Mouse
endocardium development GO:0003157 10 0.955
regulation of metanephric mesenchymal cell migration GO:2000589 2 0.954
Mouse
platelet derived growth factor receptor signaling pathway GO:0048008 32 0.951
Mouse
cell migration involved in kidney development GO:0035787 3 0.950
Mouse
single organismal cell cell adhesion GO:0016337 131 0.945
Mouse
branching involved in salivary gland morphogenesis GO:0060445 26 0.943
cytokine production involved in immune response GO:0002367 34 0.942
Mouse
megakaryocyte differentiation GO:0030219 26 0.940
Mouse
cellular response to stem cell factor stimulus GO:0036216 3 0.934
Mouse
glomerular capillary formation GO:0072104 6 0.934
Mouse
regulation of endothelial cell migration GO:0010594 22 0.933
Human
neuropilin signaling pathway GO:0038189 2 0.933
glomerulus morphogenesis GO:0072102 10 0.930
Mouse
renal system vasculature development GO:0061437 15 0.927
Mouse
response to erythropoietin GO:0036017 1 0.925
Mouse
regulation of vasculature development GO:1901342 88 0.921
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.920
angiogenesis involved in coronary vascular morphogenesis GO:0060978 2 0.918
Mouse
erythrocyte differentiation GO:0030218 88 0.917
Mouse
metanephric glomerular endothelium development GO:0072264 1 0.914
vascular endothelial growth factor receptor signaling pathway GO:0048010 24 0.914
kidney development GO:0001822 213 0.911
Mouse
kidney vasculature morphogenesis GO:0061439 7 0.909
Mouse
endothelium development GO:0003158 45 0.907
cardiac muscle fiber development GO:0048739 4 0.906
metanephric glomerulus development GO:0072224 13 0.906
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.904
development of primary sexual characteristics GO:0045137 143 0.902
positive regulation of cell adhesion GO:0045785 80 0.901
Human
glomerular mesangial cell proliferation GO:0072110 3 0.896
Mouse
melanocyte differentiation GO:0030318 25 0.895
Mouse
melanocyte adhesion GO:0097326 1 0.894
Mouse
blood vessel morphogenesis GO:0048514 285 0.893
platelet derived growth factor receptor alpha signaling pathway GO:0035790 3 0.885
Mouse
amine metabolic process GO:0009308 45 0.882
regulation of cellular amine metabolic process GO:0033238 20 0.877
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.876
chemical homeostasis within a tissue GO:0048875 9 0.873
axonogenesis GO:0007409 274 0.867
metanephric glomerular capillary formation GO:0072277 3 0.866
Mouse
angiogenesis GO:0001525 201 0.861
epithelial tube morphogenesis GO:0060562 303 0.852
positive regulation of metanephric mesenchymal cell migration GO:2000591 1 0.851
Mouse
regulation of endothelial cell differentiation GO:0045601 10 0.838
pro b cell differentiation GO:0002328 10 0.836
Mouse
renal system vasculature morphogenesis GO:0061438 7 0.836
Mouse
positive regulation of bmp signaling pathway GO:0030513 23 0.830
artery development GO:0060840 53 0.828
Mouse
renal system process involved in regulation of blood volume GO:0001977 4 0.827
cardiac myofibril assembly GO:0055003 12 0.827
Mouse
endothelial cell differentiation GO:0045446 41 0.823
cellular response to growth factor stimulus GO:0071363 197 0.822
venous blood vessel morphogenesis GO:0048845 7 0.818
heart trabecula morphogenesis GO:0061384 26 0.814
epithelium migration GO:0090132 63 0.812
phosphatidylinositol metabolic process GO:0046488 45 0.810
Mouse
aorta morphogenesis GO:0035909 22 0.807
Mouse
kit signaling pathway GO:0038109 3 0.803
Mouse
glomerulus vasculature morphogenesis GO:0072103 6 0.792
Mouse
venous blood vessel development GO:0060841 13 0.789
ovulation cycle GO:0042698 59 0.788
commissural neuron axon guidance GO:0071679 8 0.788
regulation of hematopoietic progenitor cell differentiation GO:1901532 18 0.784
detection of mechanical stimulus involved in sensory perception GO:0050974 23 0.780
Mouse
cardiac cell development GO:0055006 41 0.770
Mouse
regulation of cell projection organization GO:0031344 206 0.764
heart morphogenesis GO:0003007 178 0.759
spermatid differentiation GO:0048515 115 0.759
Mouse
epithelial cell migration GO:0010631 63 0.756
single organism cell adhesion GO:0098602 156 0.752
Mouse
tissue migration GO:0090130 68 0.746
blood vessel endothelial cell migration GO:0043534 23 0.738
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 20 0.737
Human Mouse
negative regulation of cell proliferation GO:0008285 296 0.736
Mouse
muscle tissue development GO:0060537 308 0.734
Mouse
lymphocyte differentiation GO:0030098 242 0.729
Mouse
cardiac chamber morphogenesis GO:0003206 93 0.729
coronary vasculature development GO:0060976 12 0.722
Mouse
pigmentation GO:0043473 71 0.714
Mouse
metanephric mesangial cell differentiation GO:0072209 1 0.714
stem cell proliferation GO:0072089 117 0.713
male gamete generation GO:0048232 285 0.710
Mouse
salivary gland morphogenesis GO:0007435 33 0.708
Fly
developmental maturation GO:0021700 193 0.705
lymph vessel morphogenesis GO:0036303 11 0.702
Mouse
stem cell differentiation GO:0048863 268 0.701
Mouse
positive regulation of behavior GO:0048520 40 0.691
Human Mouse
dna biosynthetic process GO:0071897 22 0.688
Mouse
cardiocyte differentiation GO:0035051 87 0.686
Mouse
muscle cell migration GO:0014812 19 0.678
Mouse
epithelial cell proliferation GO:0050673 174 0.672
renal system development GO:0072001 225 0.668
Mouse Fly
positive regulation of cellular amine metabolic process GO:0033240 5 0.666
regulation of chemotaxis GO:0050920 53 0.663
Human Mouse
positive regulation of angiogenesis GO:0045766 46 0.663
positive regulation of protein modification process GO:0031401 299 0.663
Human Mouse
glomerulus vasculature development GO:0072012 14 0.662
Mouse
spermatid development GO:0007286 108 0.662
Mouse
positive regulation of cell migration GO:0030335 109 0.661
Human Mouse
endothelial cell migration GO:0043542 44 0.660
immature b cell differentiation GO:0002327 10 0.657
Mouse
glomerular mesangial cell differentiation GO:0072008 3 0.654
positive regulation of dna biosynthetic process GO:2000573 4 0.648
Mouse
negative regulation of b cell activation GO:0050869 27 0.640
Mouse
estrogen metabolic process GO:0008210 8 0.637
Mouse
muscle cell differentiation GO:0042692 261 0.634
Mouse
cellular component assembly involved in morphogenesis GO:0010927 139 0.630
Mouse
urogenital system development GO:0001655 261 0.629
Mouse Fly
negative regulation of cell migration GO:0030336 59 0.627
lung alveolus development GO:0048286 45 0.620
production of molecular mediator of immune response GO:0002440 103 0.619
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.615
Mouse
mesenchymal cell proliferation GO:0010463 44 0.605
gonadotrophin releasing hormone neuronal migration to the hypothalamus GO:0021828 3 0.599
sensory perception of mechanical stimulus GO:0050954 107 0.598
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.594
smooth muscle tissue development GO:0048745 22 0.593
Mouse
positive regulation of protein kinase c signaling GO:0090037 1 0.587
regulation of epithelial cell migration GO:0010632 35 0.585
Human
gland development GO:0048732 330 0.580
Mouse Fly
regulation of protein serine threonine kinase activity GO:0071900 157 0.577
Mouse
lymphoid progenitor cell differentiation GO:0002320 17 0.577
Mouse
glomerular mesangial cell development GO:0072144 3 0.575
positive regulation of endothelial cell migration GO:0010595 12 0.572
Human
response to thyroid hormone GO:0097066 2 0.571
Mouse
positive regulation of lymphangiogenesis GO:1901492 3 0.569
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.568
regulation of axon guidance GO:1902667 13 0.567
regulation of cell migration GO:0030334 219 0.567
Human Mouse
detection of stimulus GO:0051606 84 0.566
Mouse
tyrosine phosphorylation of stat3 protein GO:0042503 12 0.562
Mouse
cellular response to macrophage colony stimulating factor stimulus GO:0036006 3 0.562
Mouse
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 14 0.557
development of primary male sexual characteristics GO:0046546 88 0.557
Mouse
protein o linked glycosylation GO:0006493 16 0.552
ameboidal type cell migration GO:0001667 128 0.547
cardiac muscle cell development GO:0055013 39 0.542
Mouse
hypothalamus gonadotrophin releasing hormone neuron development GO:0021888 4 0.540
neuron projection guidance GO:0097485 141 0.539
nephron development GO:0072006 109 0.538
Mouse
hematopoietic progenitor cell differentiation GO:0002244 143 0.537
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.536
b cell differentiation GO:0030183 78 0.533
Mouse
regulation of lymphocyte activation GO:0051249 240 0.531
Mouse
regulation of glomerular filtration GO:0003093 3 0.528
regulation of retinal ganglion cell axon guidance GO:0090259 2 0.517
cellular amine metabolic process GO:0044106 44 0.509
cellular amino acid metabolic process GO:0006520 103 0.508
ion transmembrane transport GO:0034220 361 0.507
Mouse
t cell differentiation GO:0030217 174 0.506
Mouse
cell fate commitment GO:0045165 210 0.503
peptidyl amino acid modification GO:0018193 336 0.502
regulation of cell growth GO:0001558 91 0.500
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.499
Mouse Fly
positive regulation of neuron projection development GO:0010976 79 0.497
response to peptide hormone GO:0043434 127 0.496
Fly
neuroepithelial cell differentiation GO:0060563 37 0.492
Mouse
dendritic cell differentiation GO:0097028 26 0.491
Mouse
humoral immune response GO:0006959 57 0.490
Fly
extracellular matrix organization GO:0030198 147 0.489
Mouse
retina development in camera type eye GO:0060041 119 0.488
Mouse
regulation of map kinase activity GO:0043405 120 0.486
Mouse
gonad development GO:0008406 141 0.486
salivary gland development GO:0007431 37 0.485
Fly
negative regulation of lymphocyte differentiation GO:0045620 32 0.484
Mouse
positive regulation of mesenchymal cell proliferation GO:0002053 33 0.482
macrophage colony stimulating factor signaling pathway GO:0038145 2 0.479
Mouse
positive regulation of epithelial cell migration GO:0010634 19 0.478
Human
cell adhesion GO:0007155 329 0.476
Human Mouse
homeostasis of number of cells GO:0048872 210 0.472
Mouse Fly
embryonic organ morphogenesis GO:0048562 276 0.470
Mouse
ovarian follicle development GO:0001541 40 0.469
membrane lipid metabolic process GO:0006643 53 0.466
Mouse
positive chemotaxis GO:0050918 18 0.465
Human
trunk neural crest cell migration GO:0036484 4 0.465
regulation of cellular response to growth factor stimulus GO:0090287 82 0.463
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.458
Human Mouse
glomerulus development GO:0032835 40 0.458
Mouse
peptidyl tyrosine modification GO:0018212 145 0.457
exocrine system development GO:0035272 45 0.454
Fly
positive regulation of neuron differentiation GO:0045666 141 0.453
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.450
Mouse
cell chemotaxis GO:0060326 81 0.448
Mouse
cardiac muscle tissue development GO:0048738 130 0.444
Mouse
peptidyl tyrosine phosphorylation GO:0018108 143 0.444
epithelial cell cell adhesion GO:0090136 6 0.444
Mouse
germ cell development GO:0007281 185 0.443
Mouse Fly
morphogenesis of a branching epithelium GO:0061138 193 0.437
embryonic digestive tract development GO:0048566 27 0.429
Mouse
coronary artery morphogenesis GO:0060982 6 0.428
blood circulation GO:0008015 195 0.426
luteinization GO:0001553 8 0.423
Mouse
regulation of mesenchymal cell proliferation GO:0010464 37 0.422
positive regulation of cell substrate adhesion GO:0010811 47 0.421
Human
regulation of bmp signaling pathway GO:0030510 60 0.420
regulation of stem cell proliferation GO:0072091 78 0.419
positive regulation of cell development GO:0010720 237 0.418
regulation of epithelial cell proliferation GO:0050678 141 0.418
regulation of branching involved in salivary gland morphogenesis by epithelial mesenchymal signaling GO:0060683 1 0.416
positive regulation of growth GO:0045927 104 0.416
response to oxygen levels GO:0070482 62 0.409
Mouse
primitive erythrocyte differentiation GO:0060319 3 0.406
erythropoietin mediated signaling pathway GO:0038162 1 0.406
Mouse
glycolipid metabolic process GO:0006664 25 0.399
Mouse
odontogenesis of dentin containing tooth GO:0042475 66 0.399
Mouse
cell migration involved in heart development GO:0060973 8 0.398
Mouse
regulation of peptidyl serine phosphorylation GO:0033135 39 0.394
trabecula morphogenesis GO:0061383 40 0.394
sprouting angiogenesis GO:0002040 26 0.394
cerebral cortex tangential migration using cell axon interactions GO:0021824 3 0.391
cell migration involved in metanephros development GO:0035788 2 0.391
Mouse
connective tissue development GO:0061448 179 0.391
Mouse
spermatogenesis GO:0007283 284 0.391
Mouse
positive regulation of retinal ganglion cell axon guidance GO:1902336 2 0.389
positive regulation of mitotic cell cycle GO:0045931 41 0.386
Mouse
regulation of secretion GO:0051046 274 0.384
detection of abiotic stimulus GO:0009582 60 0.383
Mouse
camera type eye development GO:0043010 266 0.383
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.382
Mouse
metanephric glomerulus vasculature development GO:0072239 7 0.381
Mouse
mast cell differentiation GO:0060374 5 0.379
Mouse
neuron projection extension involved in neuron projection guidance GO:1902284 14 0.376
positive regulation of chemotaxis GO:0050921 38 0.374
Human Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.371
Human Mouse
female gonad development GO:0008585 71 0.371
positive regulation of cell growth GO:0030307 33 0.365
negative regulation of lymphocyte activation GO:0051250 91 0.361
Mouse
positive regulation of cell motility GO:2000147 116 0.360
Human Mouse
inositol lipid mediated signaling GO:0048017 41 0.359
Human Mouse
regulation of kidney development GO:0090183 40 0.359
Mouse
regulation of cell size GO:0008361 72 0.357
cation homeostasis GO:0055080 212 0.355
chemotaxis GO:0006935 247 0.346
Human Mouse
protein localization to endosome GO:0036010 2 0.345
renal tubule development GO:0061326 87 0.344
Fly
regulation of jak stat cascade GO:0046425 34 0.344
Mouse
mesonephric tubule development GO:0072164 94 0.340
ectopic germ cell programmed cell death GO:0035234 9 0.340
Mouse
response to stem cell factor GO:0036215 3 0.339
Mouse
negative regulation of immune system process GO:0002683 209 0.337
Mouse
regulation of transmembrane transport GO:0034762 128 0.337
Mouse
cellular response to amino acid stimulus GO:0071230 29 0.337
Mouse
mapk cascade GO:0000165 281 0.337
Human Mouse Fly
myeloid cell homeostasis GO:0002262 114 0.335
Mouse
digestive tract development GO:0048565 190 0.334
Mouse Fly
muscle cell proliferation GO:0033002 52 0.332
Mouse
sympathetic neuron projection extension GO:0097490 4 0.331
lung vasculature development GO:0060426 7 0.330
hypothalamic tangential migration using cell axon interactions GO:0021856 3 0.329
positive regulation of creb transcription factor activity GO:0032793 4 0.327
positive regulation of cell cycle process GO:0090068 61 0.326
Mouse
multicellular organismal homeostasis GO:0048871 164 0.325
retinal ganglion cell axon guidance GO:0031290 18 0.324
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.323
positive regulation of jak stat cascade GO:0046427 22 0.322
Mouse
regulation of positive chemotaxis GO:0050926 7 0.322
Human
jak stat cascade GO:0007259 42 0.322
Mouse
brain morphogenesis GO:0048854 32 0.320
embryonic heart tube development GO:0035050 65 0.317
sensory organ morphogenesis GO:0090596 242 0.316
positive regulation of endothelial cell chemotaxis GO:2001028 1 0.316
cell cell junction organization GO:0045216 72 0.315
Human
morphogenesis of embryonic epithelium GO:0016331 159 0.314
cytokine production GO:0001816 319 0.313
Mouse
mesonephric tubule morphogenesis GO:0072171 63 0.312
cellular ketone metabolic process GO:0042180 84 0.309
anatomical structure homeostasis GO:0060249 145 0.309
regulation of lymphocyte differentiation GO:0045619 107 0.308
Mouse
regulation of protein kinase c signaling GO:0090036 5 0.306
cell substrate adhesion GO:0031589 130 0.305
Human
female sex differentiation GO:0046660 84 0.303
positive regulation of axon extension GO:0045773 20 0.299
membrane organization GO:0061024 245 0.297
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.296
Mouse
mesangial cell differentiation GO:0072007 4 0.294
digestive tract morphogenesis GO:0048546 147 0.294
Mouse Fly
male sex differentiation GO:0046661 109 0.293
Mouse Fly
pigment cell differentiation GO:0050931 27 0.292
Mouse
peptidyl serine phosphorylation GO:0018105 74 0.291
male gonad development GO:0008584 88 0.290
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.288
Mouse
positive regulation of ion transmembrane transport GO:0034767 24 0.288
Mouse
morphogenesis of a branching structure GO:0001763 203 0.287
central nervous system neuron differentiation GO:0021953 162 0.286
mesonephros development GO:0001823 97 0.284
renal tubule morphogenesis GO:0061333 72 0.283
Fly
regionalization GO:0003002 337 0.283
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.281
detection of external stimulus GO:0009581 61 0.278
Mouse
cell matrix adhesion GO:0007160 68 0.277
Human
regulation of cell migration involved in sprouting angiogenesis GO:0090049 4 0.277
protein autophosphorylation GO:0046777 61 0.276
branching morphogenesis of an epithelial tube GO:0048754 159 0.276
t cell activation GO:0042110 289 0.275
Mouse
regulation of reactive oxygen species metabolic process GO:2000377 40 0.273
Mouse
regulation of ion transport GO:0043269 215 0.267
Mouse
regulation of axon extension GO:0030516 43 0.266
cardiac chamber development GO:0003205 108 0.265
glycoprotein metabolic process GO:0009100 116 0.265
regulation of apoptotic signaling pathway GO:2001233 197 0.264
myeloid progenitor cell differentiation GO:0002318 8 0.263
Mouse
positive regulation of transmembrane transport GO:0034764 29 0.263
Mouse
substrate dependent cell migration GO:0006929 18 0.260
actin cytoskeleton reorganization GO:0031532 21 0.260
Mouse
regulation of body fluid levels GO:0050878 162 0.260
stem cell development GO:0048864 219 0.259
negative regulation of cell motility GO:2000146 61 0.259
cellular response to x ray GO:0071481 2 0.258
negative regulation of leukocyte differentiation GO:1902106 51 0.257
Mouse
positive regulation of mitotic cell cycle embryonic GO:0045977 2 0.257
forebrain generation of neurons GO:0021872 63 0.255
adrenal gland development GO:0030325 18 0.253
Mouse
cell growth GO:0016049 130 0.253
developmental growth involved in morphogenesis GO:0060560 138 0.253
regulation of cell adhesion GO:0030155 154 0.252
Human
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 61 0.252
Mouse
regulation of lymphangiogenesis GO:1901490 3 0.252
embryonic skeletal system morphogenesis GO:0048704 91 0.252
Mouse
cell migration involved in endocardial cushion formation GO:0003273 3 0.251
cardiac endothelial cell differentiation GO:0003348 4 0.250
retina vasculature morphogenesis in camera type eye GO:0061299 10 0.250
embryonic hemopoiesis GO:0035162 23 0.250
plasma membrane fusion GO:0045026 9 0.249
regulation of endothelial cell chemotaxis GO:2001026 1 0.249
ruffle organization GO:0031529 16 0.247
Mouse
striated muscle tissue development GO:0014706 293 0.246
Mouse
cardiac muscle cell differentiation GO:0055007 69 0.246
Mouse
nephron tubule morphogenesis GO:0072078 68 0.246
positive regulation of ion transport GO:0043270 65 0.245
Mouse
regulation of transferase activity GO:0051338 263 0.244
Mouse
synaptic transmission GO:0007268 329 0.243
response to acid chemical GO:0001101 111 0.241
Mouse
tissue homeostasis GO:0001894 115 0.240
endothelial cell apoptotic process GO:0072577 9 0.239
Human
retinal blood vessel morphogenesis GO:0061304 3 0.238
cardiac cell fate specification GO:0060912 2 0.238
mitral valve morphogenesis GO:0003183 4 0.238
regulation of cell cycle GO:0051726 281 0.238
Mouse
glycerophospholipid metabolic process GO:0006650 71 0.237
Mouse
positive regulation of protein kinase b signaling GO:0051897 32 0.236
positive regulation of cytokine production GO:0001819 174 0.236
immune effector process GO:0002252 321 0.234
Mouse
leukocyte differentiation GO:0002521 342 0.233
Mouse
muscle fiber development GO:0048747 76 0.231
regulation of metanephros development GO:0072215 15 0.229
Mouse
protein kinase c signaling GO:0070528 7 0.229
neural crest cell development GO:0014032 48 0.226
regulation of cell motility GO:2000145 236 0.226
Human Mouse
face morphogenesis GO:0060325 29 0.225
Mouse
regulation of blood vessel endothelial cell migration GO:0043535 12 0.225
heart process GO:0003015 94 0.224
endocardial cell differentiation GO:0060956 4 0.223
paracrine signaling GO:0038001 1 0.220
mesenchymal cell differentiation GO:0048762 107 0.220
lung development GO:0030324 164 0.220
epithelial cell differentiation involved in kidney development GO:0035850 23 0.219
cardiac muscle tissue morphogenesis GO:0055008 44 0.219
cell proliferation involved in kidney development GO:0072111 14 0.217
Mouse
detection of mechanical stimulus involved in equilibrioception GO:0050973 2 0.216
atrial septum primum morphogenesis GO:0003289 3 0.216
nephron epithelium development GO:0072009 92 0.216
organelle fission GO:0048285 170 0.215
Mouse
regulation of erk1 and erk2 cascade GO:0070372 71 0.214
Human Mouse
ureteric bud morphogenesis GO:0060675 62 0.214
sympathetic neuron projection guidance GO:0097491 4 0.213
vegf activated neuropilin signaling pathway involved in axon guidance GO:1902378 1 0.213
g protein coupled receptor signaling pathway GO:0007186 243 0.212
muscle cell development GO:0055001 133 0.211
Mouse
b cell activation GO:0042113 161 0.211
Mouse
response to hypoxia GO:0001666 58 0.211
Mouse
negative regulation of b cell differentiation GO:0045578 4 0.210
Mouse
positive regulation of vasculogenesis GO:2001214 7 0.210
regulation of striated muscle cell differentiation GO:0051153 81 0.210
palate development GO:0060021 76 0.209
Mouse
positive regulation of organelle organization GO:0010638 128 0.208
Mouse
heart contraction GO:0060047 93 0.206
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.206
response to heparin GO:0071503 1 0.206
calcium ion transport GO:0006816 159 0.204
Mouse
smooth muscle cell chemotaxis GO:0071670 2 0.202
Mouse
vascular process in circulatory system GO:0003018 62 0.200
leukocyte homeostasis GO:0001776 79 0.200
Mouse
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.198
trabecula formation GO:0060343 24 0.197
glomerular mesangium development GO:0072109 5 0.197
Mouse
glomerular endothelium development GO:0072011 2 0.197
wound healing GO:0042060 157 0.197
Mouse
genitalia development GO:0048806 37 0.197
Mouse Fly
microtubule based process GO:0007017 236 0.196
Fly
negative regulation of endothelial cell apoptotic process GO:2000352 7 0.196
Human
kidney morphogenesis GO:0060993 83 0.196
regulation of hippo signaling GO:0035330 1 0.195
p38mapk cascade GO:0038066 4 0.193
sphingolipid metabolic process GO:0006665 45 0.193
Mouse
positive regulation of cytokine secretion involved in immune response GO:0002741 2 0.192
blastocyst development GO:0001824 80 0.192
regulation of extent of cell growth GO:0061387 52 0.192
regulation of kinase activity GO:0043549 249 0.191
Mouse
protein localization to early endosome GO:1902946 1 0.191
regulation of system process GO:0044057 200 0.189
epithelial cell proliferation involved in prostatic bud elongation GO:0060517 1 0.187
septum primum development GO:0003284 4 0.186
myeloid cell differentiation GO:0030099 233 0.183
Mouse
organelle assembly GO:0070925 177 0.183
Mouse
regulation of calcium ion transport GO:0051924 69 0.181
Mouse
response to retinoic acid GO:0032526 56 0.180
response to growth factor GO:0070848 198 0.177
positive regulation of cell cycle GO:0045787 92 0.177
Mouse
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 10 0.177
Mouse
cell junction assembly GO:0034329 52 0.176
Human
retina morphogenesis in camera type eye GO:0060042 45 0.176
positive regulation of protein autophosphorylation GO:0031954 4 0.175
neuron migration GO:0001764 122 0.175
regulation of protein kinase activity GO:0045859 232 0.173
Mouse
embryonic digestive tract morphogenesis GO:0048557 17 0.172
Mouse
hair cycle GO:0042633 90 0.172
outflow tract morphogenesis GO:0003151 53 0.171
axon guidance GO:0007411 141 0.171
regulation of endothelial cell proliferation GO:0001936 23 0.171
Human
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.168
nephron tubule development GO:0072080 84 0.168
glycerolipid metabolic process GO:0046486 122 0.166
Mouse
development of primary female sexual characteristics GO:0046545 73 0.165
regulation of cell activation GO:0050865 289 0.165
Mouse
bmp signaling pathway GO:0030509 93 0.163
negative regulation of angiogenesis GO:0016525 25 0.162
endodermal cell fate determination GO:0007493 2 0.162
negative regulation of nervous system development GO:0051961 156 0.161
positive regulation of stem cell proliferation GO:2000648 59 0.161
regulation of anatomical structure size GO:0090066 178 0.161
neural tube formation GO:0001841 108 0.160
cytoplasmic transport GO:0016482 234 0.160
regulation of heart growth GO:0060420 31 0.159
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 30 0.159
Human Mouse
positive regulation of peptidyl serine phosphorylation GO:0033138 25 0.159
regulation of developmental pigmentation GO:0048070 14 0.158
Mouse
negative regulation of cell development GO:0010721 169 0.157
regulation of tyrosine phosphorylation of stat protein GO:0042509 20 0.157
Mouse
motor neuron axon guidance GO:0008045 26 0.157
regulation of rho gtpase activity GO:0032319 58 0.157
regulation of wnt signaling pathway GO:0030111 123 0.156
regulation of cardiac cell fate specification GO:2000043 1 0.156
metanephric nephron development GO:0072210 34 0.156
Mouse
positive regulation of transferase activity GO:0051347 167 0.155
Mouse
ascending aorta development GO:0035905 3 0.155
ureteric bud development GO:0001657 94 0.155
cardiac vascular smooth muscle cell development GO:0060948 3 0.154
neuron projection extension GO:1990138 64 0.153
ascending aorta morphogenesis GO:0035910 3 0.152
rhythmic process GO:0048511 174 0.152
mesonephric epithelium development GO:0072163 94 0.150
negative regulation of phosphorus metabolic process GO:0010563 184 0.149
renal filtration GO:0097205 7 0.149
regulation of cytokine production GO:0001817 266 0.148
positive regulation of calcium ion transport GO:0051928 27 0.145
Mouse
endodermal cell fate specification GO:0001714 4 0.144
nephron epithelium morphogenesis GO:0072088 68 0.143
leukocyte migration GO:0050900 124 0.143
regulation of cell division GO:0051302 76 0.142
Mouse
cell type specific apoptotic process GO:0097285 268 0.142
Human
negative regulation of platelet derived growth factor receptor signaling pathway GO:0010642 7 0.141
negative regulation of endothelial cell migration GO:0010596 4 0.141
regulation of cellular component size GO:0032535 121 0.139
positive regulation of neuroblast proliferation GO:0002052 19 0.138
erk1 and erk2 cascade GO:0070371 77 0.138
Human Mouse
chondrocyte hypertrophy GO:0003415 4 0.138
skeletal system morphogenesis GO:0048705 203 0.137
Mouse
central nervous system projection neuron axonogenesis GO:0021952 21 0.137

Kdr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.891
disease of anatomical entity DOID:7 0 0.891
lymphatic system disease DOID:75 0 0.891
muscular disease DOID:0080000 0 0.138
musculoskeletal system disease DOID:17 0 0.138
muscle tissue disease DOID:66 0 0.138