Mus musculus

76 known processes

Kl

klotho

(Aliases: alpha-kl)

Kl biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular phosphate ion homeostasis GO:0030643 2 1.000
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.996
regulation of secretion by cell GO:1903530 249 0.990
amine metabolic process GO:0009308 45 0.989
steroid metabolic process GO:0008202 119 0.988
cellular ketone metabolic process GO:0042180 84 0.987
muscle contraction GO:0006936 101 0.987
carbohydrate metabolic process GO:0005975 230 0.985
regulation of tube size GO:0035150 57 0.985
positive regulation of nucleotide metabolic process GO:0045981 114 0.980
regulation of hormone levels GO:0010817 211 0.978
regulation of ion transport GO:0043269 215 0.975
regulation of nucleotide metabolic process GO:0006140 169 0.975
regulation of purine nucleotide metabolic process GO:1900542 169 0.973
nucleoside triphosphate metabolic process GO:0009141 230 0.972
cellular amine metabolic process GO:0044106 44 0.971
fibroblast growth factor receptor signaling pathway GO:0008543 46 0.969
glycosyl compound catabolic process GO:1901658 206 0.969
positive regulation of heart rate by epinephrine norepinephrine GO:0001996 4 0.969
protein kinase c activating g protein coupled receptor signaling pathway GO:0007205 4 0.968
ribonucleoside catabolic process GO:0042454 206 0.966
organophosphate catabolic process GO:0046434 232 0.965
negative regulation of lipid metabolic process GO:0045833 30 0.964
vasodilation by norepinephrine epinephrine involved in regulation of systemic arterial blood pressure GO:0002025 3 0.964
nucleoside metabolic process GO:0009116 246 0.964
nucleoside phosphate metabolic process GO:0006753 338 0.962
ion transmembrane transport GO:0034220 361 0.962
regulation of blood pressure GO:0008217 93 0.956
regulation of steroid biosynthetic process GO:0050810 26 0.956
inorganic anion transport GO:0015698 43 0.956
generation of precursor metabolites and energy GO:0006091 103 0.954
erk1 and erk2 cascade GO:0070371 77 0.953
organic hydroxy compound metabolic process GO:1901615 203 0.953
divalent inorganic cation transport GO:0072511 178 0.953
histamine induced gastric acid secretion GO:0001697 1 0.952
purine nucleoside catabolic process GO:0006152 205 0.950
positive regulation of camp metabolic process GO:0030816 19 0.945
organic cyclic compound catabolic process GO:1901361 295 0.945
lipid biosynthetic process GO:0008610 179 0.944
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.943
guanosine containing compound metabolic process GO:1901068 144 0.938
activation of adenylate cyclase activity GO:0007190 4 0.937
positive regulation of secretion by cell GO:1903532 114 0.936
g protein coupled receptor internalization GO:0002031 3 0.935
circulatory system process GO:0003013 197 0.932
ribonucleoside triphosphate catabolic process GO:0009203 199 0.932
response to fibroblast growth factor GO:0071774 47 0.930
nucleoside phosphate catabolic process GO:1901292 222 0.925
purine nucleotide metabolic process GO:0006163 302 0.924
amide transport GO:0042886 138 0.924
regulation of nucleoside metabolic process GO:0009118 130 0.924
myoblast differentiation involved in skeletal muscle regeneration GO:0014835 3 0.922
peptide transport GO:0015833 133 0.921
purine ribonucleotide metabolic process GO:0009150 290 0.920
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 55 0.917
positive regulation of the force of heart contraction by epinephrine norepinephrine GO:0001997 3 0.915
response to organonitrogen compound GO:0010243 246 0.914
purine nucleoside triphosphate metabolic process GO:0009144 226 0.903
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.900
regulation of systemic arterial blood pressure by norepinephrine epinephrine GO:0001993 8 0.899
regulation of systemic arterial blood pressure GO:0003073 61 0.899
steroid biosynthetic process GO:0006694 47 0.898
temperature homeostasis GO:0001659 26 0.895
ribonucleotide metabolic process GO:0009259 291 0.893
cellular lipid metabolic process GO:0044255 323 0.893
response to nutrient levels GO:0031667 109 0.892
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 30 0.892
regulation of peptide hormone secretion GO:0090276 75 0.892
calcium ion transport GO:0006816 159 0.891
forebrain generation of neurons GO:0021872 63 0.891
regulation of hormone secretion GO:0046883 88 0.890
nucleotide catabolic process GO:0009166 217 0.889
peptidyl amino acid modification GO:0018193 336 0.888
organic acid transport GO:0015849 101 0.887
purine ribonucleoside catabolic process GO:0046130 205 0.886
ossification GO:0001503 216 0.885
hormone metabolic process GO:0042445 86 0.881
g protein coupled receptor signaling pathway GO:0007186 243 0.880
monocarboxylic acid metabolic process GO:0032787 191 0.880
regulation of metal ion transport GO:0010959 106 0.878
regulation of anatomical structure size GO:0090066 178 0.878
positive regulation of nucleotide biosynthetic process GO:0030810 26 0.877
nitrogen compound transport GO:0071705 271 0.876
regulation of purine nucleotide catabolic process GO:0033121 122 0.875
cation homeostasis GO:0055080 212 0.874
regulation of cellular amine metabolic process GO:0033238 20 0.871
ribose phosphate metabolic process GO:0019693 291 0.870
regulation of peptide secretion GO:0002791 77 0.869
regulation of camp biosynthetic process GO:0030817 25 0.867
carbohydrate derivative biosynthetic process GO:1901137 183 0.860
hormone biosynthetic process GO:0042446 16 0.859
cellular divalent inorganic anion homeostasis GO:0072501 3 0.859
cation transport GO:0006812 399 0.856
cellular nitrogen compound catabolic process GO:0044270 280 0.856
organic hydroxy compound transport GO:0015850 93 0.855
transmembrane transport GO:0055085 412 0.855
positive regulation of lyase activity GO:0051349 11 0.854
second messenger mediated signaling GO:0019932 73 0.851
glycosyl compound metabolic process GO:1901657 246 0.851
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway GO:0051482 4 0.850
cellular response to organonitrogen compound GO:0071417 145 0.848
forebrain neuron development GO:0021884 30 0.848
cellular response to fibroblast growth factor stimulus GO:0044344 47 0.843
lipid catabolic process GO:0016042 69 0.843
type b pancreatic cell proliferation GO:0044342 10 0.839
regulation of cellular ketone metabolic process GO:0010565 66 0.839
wnt signaling pathway involved in forebrain neuroblast division GO:0021874 2 0.836
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.833
cytosolic calcium ion homeostasis GO:0051480 70 0.830
phospholipase c activating serotonin receptor signaling pathway GO:0007208 1 0.825
regulation of secretion GO:0051046 274 0.823
positive regulation of secretion GO:0051047 130 0.822
carboxylic acid biosynthetic process GO:0046394 86 0.820
purine nucleotide catabolic process GO:0006195 211 0.816
anion transport GO:0006820 177 0.815
bone remodeling GO:0046849 53 0.814
regulation of cyclic nucleotide biosynthetic process GO:0030802 31 0.814
camp mediated signaling GO:0019933 15 0.811
positive regulation of atpase activity GO:0032781 3 0.811
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.809
regulation of nucleotide catabolic process GO:0030811 122 0.807
homotypic cell cell adhesion GO:0034109 28 0.805
purine containing compound catabolic process GO:0072523 213 0.803
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.801
multicellular organism growth GO:0035264 161 0.800
regulation of hydrolase activity GO:0051336 246 0.798
cellular response to peptide GO:1901653 92 0.798
regulation of camp metabolic process GO:0030814 30 0.797
organonitrogen compound catabolic process GO:1901565 264 0.797
central nervous system morphogenesis GO:0021551 2 0.796
purine ribonucleoside metabolic process GO:0046128 241 0.791
positive regulation of mapk cascade GO:0043410 170 0.787
axis elongation involved in somitogenesis GO:0090245 4 0.786
biological phase GO:0044848 20 0.785
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.783
mesonephric duct formation GO:0072181 2 0.783
cellular carbohydrate metabolic process GO:0044262 119 0.780
negative regulation of muscle contraction GO:0045932 12 0.776
nucleoside monophosphate metabolic process GO:0009123 85 0.775
blood circulation GO:0008015 195 0.774
purine ribonucleotide catabolic process GO:0009154 208 0.771
planar cell polarity pathway involved in cardiac muscle tissue morphogenesis GO:0061350 2 0.771
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.768
epithelial tube morphogenesis GO:0060562 303 0.756
cellular response to hormone stimulus GO:0032870 150 0.753
metal ion homeostasis GO:0055065 189 0.751
regulation of blood circulation GO:1903522 93 0.747
regulation of body fluid levels GO:0050878 162 0.744
regulation of adenylate cyclase activity GO:0045761 10 0.743
regulation of ossification GO:0030278 112 0.743
cyclic purine nucleotide metabolic process GO:0052652 43 0.743
hormone secretion GO:0046879 128 0.742
positive regulation of cellular catabolic process GO:0031331 148 0.741
gastrin induced gastric acid secretion GO:0001698 1 0.739
negative regulation of growth GO:0045926 99 0.737
nucleoside catabolic process GO:0009164 206 0.737
response to amine GO:0014075 16 0.736
cyclic nucleotide metabolic process GO:0009187 59 0.732
purine nucleoside triphosphate catabolic process GO:0009146 203 0.728
peptidyl tyrosine modification GO:0018212 145 0.727
planar cell polarity pathway involved in cardiac right atrium morphogenesis GO:0061349 2 0.727
vascular process in circulatory system GO:0003018 62 0.723
bone mineralization GO:0030282 54 0.721
regulation of serotonin secretion GO:0014062 3 0.712
response to vitamin d GO:0033280 3 0.708
regulation of carbohydrate metabolic process GO:0006109 75 0.708
peptide secretion GO:0002790 114 0.707
regulation of testosterone biosynthetic process GO:2000224 2 0.707
nucleobase containing small molecule metabolic process GO:0055086 352 0.707
peptide hormone secretion GO:0030072 109 0.707
action potential GO:0001508 78 0.704
regulation of membrane potential GO:0042391 192 0.698
cellular calcium ion homeostasis GO:0006874 119 0.697
morphogenesis of a branching structure GO:0001763 203 0.696
regulation of ras gtpase activity GO:0032318 88 0.696
ribonucleoside metabolic process GO:0009119 245 0.695
mapk cascade GO:0000165 281 0.694
positive regulation of nucleotide catabolic process GO:0030813 88 0.693
positive regulation of cyclic nucleotide metabolic process GO:0030801 24 0.692
neuron migration GO:0001764 122 0.690
negative regulation of serotonin secretion GO:0014063 2 0.690
rhodopsin mediated signaling pathway GO:0016056 4 0.685
mammary gland epithelium development GO:0061180 65 0.683
planar cell polarity pathway involved in ventricular septum morphogenesis GO:0061348 2 0.683
purine containing compound metabolic process GO:0072521 311 0.682
carbohydrate derivative catabolic process GO:1901136 231 0.680
response to organic cyclic compound GO:0014070 198 0.679
regulation of bone mineralization GO:0030500 31 0.678
adult behavior GO:0030534 135 0.677
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.676
gas homeostasis GO:0033483 3 0.675
hemostasis GO:0007599 78 0.673
regulation of peptide transport GO:0090087 91 0.672
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 33 0.670
acid secretion GO:0046717 33 0.668
cellular chemical homeostasis GO:0055082 215 0.665
negative regulation of systemic arterial blood pressure GO:0003085 15 0.664
purine nucleoside metabolic process GO:0042278 241 0.664
ribonucleotide catabolic process GO:0009261 208 0.663
camp biosynthetic process GO:0006171 31 0.662
divalent metal ion transport GO:0070838 172 0.661
response to amino acid GO:0043200 37 0.661
multicellular organismal homeostasis GO:0048871 164 0.660
positive regulation of blood pressure by epinephrine norepinephrine GO:0003321 6 0.654
cellular amino acid metabolic process GO:0006520 103 0.651
regulation of corticotropin releasing hormone secretion GO:0043397 2 0.649
response to extracellular stimulus GO:0009991 127 0.645
energy reserve metabolic process GO:0006112 39 0.644
memory GO:0007613 58 0.644
cellular ion homeostasis GO:0006873 165 0.643
positive regulation of gtpase activity GO:0043547 85 0.642
blood coagulation GO:0007596 76 0.642
regulation of lipid metabolic process GO:0019216 118 0.637
ribonucleoside triphosphate metabolic process GO:0009199 220 0.633
regulation of calcium ion transport GO:0051924 69 0.633
positive regulation of transforming growth factor beta2 production GO:0032915 2 0.633
muscle system process GO:0003012 141 0.632
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.631
mammary gland branching involved in pregnancy GO:0060745 6 0.627
sensitization GO:0046960 2 0.625
positive regulation of glycolytic process GO:0045821 4 0.623
positive regulation of ras gtpase activity GO:0032320 65 0.623
divalent inorganic cation homeostasis GO:0072507 138 0.621
serotonin receptor signaling pathway GO:0007210 8 0.620
positive regulation of hydrolase activity GO:0051345 148 0.618
cellular homeostasis GO:0019725 240 0.616
calcium ion homeostasis GO:0055074 127 0.613
inorganic ion transmembrane transport GO:0098660 234 0.612
positive regulation of camp biosynthetic process GO:0030819 19 0.605
cellular divalent inorganic cation homeostasis GO:0072503 127 0.605
protein localization to organelle GO:0033365 185 0.601
tertiary branching involved in mammary gland duct morphogenesis GO:0060748 3 0.600
nucleoside triphosphate catabolic process GO:0009143 205 0.599
regulation of neurotransmitter levels GO:0001505 87 0.593
epithelial cell development GO:0002064 159 0.589
positive regulation of nucleoside metabolic process GO:0045979 91 0.584
smooth muscle contraction GO:0006939 44 0.584
long term synaptic potentiation GO:0060291 25 0.582
trachea cartilage morphogenesis GO:0060535 4 0.581
cyclic nucleotide mediated signaling GO:0019935 18 0.581
sensory perception of taste GO:0050909 18 0.580
regulation of lyase activity GO:0051339 13 0.579
planar cell polarity pathway involved in pericardium morphogenesis GO:0061354 2 0.578
cardiac right atrium morphogenesis GO:0003213 3 0.577
positive regulation of growth GO:0045927 104 0.575
testosterone biosynthetic process GO:0061370 2 0.574
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 26 0.573
response to parathyroid hormone GO:0071107 3 0.572
positive regulation of purine nucleotide catabolic process GO:0033123 88 0.565
positive regulation of insulin secretion GO:0032024 26 0.565
glucose import GO:0046323 32 0.562
negative regulation of blood pressure GO:0045776 22 0.560
hair cycle GO:0042633 90 0.560
phospholipase c activating dopamine receptor signaling pathway GO:0060158 5 0.559
establishment of anatomical structure orientation GO:0048560 1 0.557
aromatic compound catabolic process GO:0019439 286 0.553
habituation GO:0046959 3 0.550
anatomical structure homeostasis GO:0060249 145 0.544
platelet aggregation GO:0070527 20 0.543
paraxial mesodermal cell differentiation GO:0048342 2 0.540
regulation of protein secretion GO:0050708 82 0.537
ras protein signal transduction GO:0007265 77 0.531
retina morphogenesis in camera type eye GO:0060042 45 0.529
positive regulation of osteoblast differentiation GO:0045669 34 0.528
somatotropin secreting cell differentiation GO:0060126 4 0.522
regulation of cell migration GO:0030334 219 0.519
regulation of appetite GO:0032098 12 0.516
adrenergic receptor signaling pathway GO:0071875 13 0.516
nucleoside monophosphate catabolic process GO:0009125 59 0.515
regulation of atp metabolic process GO:1903578 17 0.514
catecholamine metabolic process GO:0006584 30 0.513
response to growth factor GO:0070848 198 0.509
negative regulation of hormone biosynthetic process GO:0032353 4 0.506
androgen biosynthetic process GO:0006702 4 0.500
response to steroid hormone GO:0048545 56 0.497
heterocycle catabolic process GO:0046700 280 0.492
developmental growth involved in morphogenesis GO:0060560 138 0.489
regulation of erk1 and erk2 cascade GO:0070372 71 0.483
ribose phosphate biosynthetic process GO:0046390 59 0.483
sulfur compound metabolic process GO:0006790 100 0.483
regulation of cellular catabolic process GO:0031329 242 0.482
regulation of the force of heart contraction GO:0002026 17 0.481
positive regulation of cellular amine metabolic process GO:0033240 5 0.480
response to hypoxia GO:0001666 58 0.479
regulation of steroid metabolic process GO:0019218 39 0.479
positive regulation of the force of heart contraction by chemical signal GO:0003099 3 0.479
positive regulation of blood pressure GO:0045777 21 0.478
positive regulation of biomineral tissue development GO:0070169 12 0.476
protein modification by small protein conjugation GO:0032446 187 0.473
desensitization of g protein coupled receptor protein signaling pathway GO:0002029 5 0.473
gtp catabolic process GO:0006184 143 0.469
nucleotide metabolic process GO:0009117 332 0.469
response to light stimulus GO:0009416 135 0.468
regulation of gtp catabolic process GO:0033124 113 0.468
digestive tract development GO:0048565 190 0.466
uterus morphogenesis GO:0061038 2 0.465
regulation of synaptic transmission glutamatergic GO:0051966 19 0.461
canonical wnt signaling pathway involved in regulation of type b pancreatic cell proliferation GO:0044343 1 0.458
digestion GO:0007586 40 0.457
regulation of cellular carbohydrate metabolic process GO:0010675 75 0.449
multi multicellular organism process GO:0044706 109 0.448
response to cocaine GO:0042220 14 0.447
associative learning GO:0008306 61 0.447
nephric duct formation GO:0072179 4 0.446
adenylate cyclase activating dopamine receptor signaling pathway GO:0007191 7 0.445
neuron projection extension GO:1990138 64 0.440
response to estrogen GO:0043627 24 0.439
positive regulation of gtp catabolic process GO:0033126 85 0.437
cellular response to biotic stimulus GO:0071216 92 0.436
androgen metabolic process GO:0008209 11 0.436
tissue remodeling GO:0048771 102 0.435
purine nucleoside monophosphate metabolic process GO:0009126 81 0.433
metanephric loop of henle development GO:0072236 4 0.433
cyclic nucleotide biosynthetic process GO:0009190 44 0.433
response to alkaloid GO:0043279 34 0.432
dopamine metabolic process GO:0042417 23 0.431
vasodilation GO:0042311 28 0.429
morphogenesis of a branching epithelium GO:0061138 193 0.429
molting cycle GO:0042303 90 0.427
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 3 0.426
response to acid chemical GO:0001101 111 0.425
branching morphogenesis of an epithelial tube GO:0048754 159 0.425
positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 3 0.423
purine ribonucleoside monophosphate metabolic process GO:0009167 80 0.421
planar cell polarity pathway involved in outflow tract morphogenesis GO:0061347 2 0.420
male gamete generation GO:0048232 285 0.419
carbohydrate transport GO:0008643 62 0.414
cellular lipid catabolic process GO:0044242 52 0.414
insulin secretion GO:0030073 89 0.413
male sex differentiation GO:0046661 109 0.413
response to peptide GO:1901652 136 0.413
adult locomotory behavior GO:0008344 91 0.412
eye photoreceptor cell differentiation GO:0001754 41 0.412
negative regulation of cellular amine metabolic process GO:0033239 1 0.412
glucose metabolic process GO:0006006 92 0.411
anion transmembrane transport GO:0098656 71 0.408
organic anion transport GO:0015711 137 0.408
stem cell development GO:0048864 219 0.404
bone resorption GO:0045453 38 0.403
regulation of lipid biosynthetic process GO:0046890 54 0.403
transmission of nerve impulse GO:0019226 76 0.401
response to alcohol GO:0097305 48 0.400
regulation of mapk cascade GO:0043408 248 0.399
organ growth GO:0035265 117 0.397
regulation of system process GO:0044057 200 0.395
organophosphate biosynthetic process GO:0090407 122 0.395
development of primary sexual characteristics GO:0045137 143 0.394
positive regulation of camp mediated signaling GO:0043950 3 0.386
visual behavior GO:0007632 45 0.386
astrocyte development GO:0014002 12 0.385
guanosine containing compound catabolic process GO:1901069 144 0.382
positive regulation of adenylate cyclase activity GO:0045762 8 0.381
positive regulation of synaptic transmission glutamatergic GO:0051968 8 0.380
lung induction GO:0060492 3 0.380
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 2 0.378
positive regulation of kinase activity GO:0033674 155 0.378
serotonin transport GO:0006837 11 0.376
negative regulation of steroid metabolic process GO:0045939 8 0.374
regulation of cyclase activity GO:0031279 13 0.371
regulation of muscle contraction GO:0006937 49 0.370
peptidyl threonine modification GO:0018210 31 0.370
cytokine production GO:0001816 319 0.367
synaptic transmission GO:0007268 329 0.367
regulation of transmembrane transport GO:0034762 128 0.367
developmental cell growth GO:0048588 84 0.367
response to oxygen levels GO:0070482 62 0.365
positive regulation of interleukin 8 secretion GO:2000484 1 0.365
spemann organizer formation GO:0060061 2 0.364
neural crest cell migration GO:0001755 32 0.361
carbohydrate catabolic process GO:0016052 32 0.361
axonogenesis GO:0007409 274 0.358
toxin transport GO:1901998 38 0.356
atp metabolic process GO:0046034 75 0.355
cerebral cortex gabaergic interneuron migration GO:0021853 6 0.354
purine nucleoside monophosphate catabolic process GO:0009128 58 0.354
mesonephric duct morphogenesis GO:0072180 4 0.350
lateral sprouting involved in mammary gland duct morphogenesis GO:0060599 2 0.347
regulation of heart contraction GO:0008016 77 0.343
oxygen homeostasis GO:0032364 2 0.343
mammary gland lobule development GO:0061377 22 0.343
alpha amino acid metabolic process GO:1901605 59 0.339
positive regulation of cellular carbohydrate metabolic process GO:0010676 29 0.338
regulation of cellular amino acid metabolic process GO:0006521 5 0.337
purine ribonucleotide biosynthetic process GO:0009152 59 0.335
response to testosterone GO:0033574 3 0.333
thyroid stimulating hormone secreting cell differentiation GO:0060129 4 0.331
regulation of fat cell differentiation GO:0045598 81 0.331
regulation of biomineral tissue development GO:0070167 33 0.331
regulation of cellular component size GO:0032535 121 0.331
renal system process GO:0003014 48 0.330
ovarian follicle development GO:0001541 40 0.330
wnt signaling pathway calcium modulating pathway GO:0007223 2 0.329
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 3 0.324
ribonucleotide biosynthetic process GO:0009260 59 0.324
regulation of myeloid leukocyte differentiation GO:0002761 58 0.323
pancreas development GO:0031016 57 0.323
carbohydrate homeostasis GO:0033500 128 0.322
cellular response to insulin stimulus GO:0032869 78 0.321
purine containing compound biosynthetic process GO:0072522 70 0.320
canonical wnt signaling pathway GO:0060070 130 0.317
positive regulation of nervous system development GO:0051962 221 0.317
epithelial cell morphogenesis GO:0003382 41 0.317
positive regulation of ion transport GO:0043270 65 0.316
response to metal ion GO:0010038 47 0.315
cell adhesion GO:0007155 329 0.314
positive regulation of blood circulation GO:1903524 22 0.314
positive regulation of transferase activity GO:0051347 167 0.314
operant conditioning GO:0035106 2 0.312
regulation of the force of heart contraction by chemical signal GO:0003057 5 0.311
positive regulation of carbohydrate metabolic process GO:0045913 30 0.310
positive regulation of protein secretion GO:0050714 52 0.310
cellular metal ion homeostasis GO:0006875 151 0.309
regulation of canonical wnt signaling pathway involved in controlling type b pancreatic cell proliferation GO:2000079 1 0.308
multicellular organismal metabolic process GO:0044236 28 0.308
development of primary male sexual characteristics GO:0046546 88 0.307
renal outer medulla development GO:0072054 2 0.306
glucose transport GO:0015758 56 0.306
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 20 0.304
negative regulation of nucleotide metabolic process GO:0045980 16 0.304
glycerolipid metabolic process GO:0046486 122 0.303
sodium ion transport GO:0006814 73 0.303
monoamine transport GO:0015844 33 0.303
negative regulation of cell migration GO:0030336 59 0.302
camp metabolic process GO:0046058 40 0.300
midgut development GO:0007494 4 0.297
carboxylic acid transport GO:0046942 100 0.297
small molecule biosynthetic process GO:0044283 132 0.297
carnitine transmembrane transport GO:1902603 3 0.297
regulation of branching involved in ureteric bud morphogenesis GO:0090189 22 0.295
smoothened signaling pathway GO:0007224 105 0.295
regulation of synaptic plasticity GO:0048167 87 0.295
regulation of protein complex assembly GO:0043254 83 0.294
positive regulation of bone mineralization GO:0030501 12 0.294
regulation of extent of cell growth GO:0061387 52 0.294
phasic smooth muscle contraction GO:0014821 8 0.293
inflammatory response GO:0006954 244 0.293
positive regulation of ossification GO:0045778 47 0.292
cell growth GO:0016049 130 0.292
negative regulation of steroid biosynthetic process GO:0010894 8 0.291
regulation of ion homeostasis GO:2000021 64 0.289
feeding behavior GO:0007631 62 0.289
positive regulation of protein kinase activity GO:0045860 144 0.286
positive regulation of cell division GO:0051781 31 0.286
glial cell differentiation GO:0010001 131 0.286
synaptic transmission glutamatergic GO:0035249 36 0.285
positive regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045899 2 0.285
development of primary female sexual characteristics GO:0046545 73 0.284
small gtpase mediated signal transduction GO:0007264 97 0.282
bile acid metabolic process GO:0008206 17 0.282
hair cycle phase GO:0044851 16 0.279
neuropeptide signaling pathway GO:0007218 19 0.278
female gonad development GO:0008585 71 0.277
regulation of rho gtpase activity GO:0032319 58 0.276
cell cell adhesion GO:0098609 41 0.274
regulation of ras protein signal transduction GO:0046578 114 0.274
positive regulation of cytosolic calcium ion concentration GO:0007204 65 0.273
cellular response to vitamin d GO:0071305 2 0.272
regulation of cell division GO:0051302 76 0.272
negative regulation of axon guidance GO:1902668 8 0.271
negative regulation of androgen biosynthetic process GO:2000180 1 0.268
negative regulation of epithelial cell proliferation GO:0050680 64 0.268
positive regulation of heart rate GO:0010460 10 0.267
lipid homeostasis GO:0055088 63 0.267
sensory organ morphogenesis GO:0090596 242 0.265
monosaccharide metabolic process GO:0005996 106 0.264
rhythmic process GO:0048511 174 0.262
regulation of heart rate GO:0002027 36 0.261
calcium ion transport into cytosol GO:0060402 48 0.261
peristalsis GO:0030432 8 0.261
cerebral cortex gabaergic interneuron differentiation GO:0021892 9 0.261
regulation of purine nucleotide biosynthetic process GO:1900371 34 0.261
visual learning GO:0008542 44 0.260
tissue homeostasis GO:0001894 115 0.259
nucleotide biosynthetic process GO:0009165 78 0.258
negative regulation of hormone metabolic process GO:0032351 4 0.258
glucose homeostasis GO:0042593 128 0.257
organonitrogen compound biosynthetic process GO:1901566 192 0.257
detection of chemical stimulus involved in sensory perception of pain GO:0050968 3 0.255
positive regulation of branching involved in lung morphogenesis GO:0061047 4 0.255
negative regulation of molecular function GO:0044092 258 0.255
multicellular organismal response to stress GO:0033555 62 0.253
foregut regionalization GO:0060423 3 0.252
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.251
neuron apoptotic process GO:0051402 142 0.251
ribonucleoside monophosphate catabolic process GO:0009158 57 0.249
central nervous system neuron development GO:0021954 67 0.249

Kl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.860
inherited metabolic disorder DOID:655 0 0.860
retinal disease DOID:5679 0 0.750
retinal degeneration DOID:8466 0 0.750
sensory system disease DOID:0050155 0 0.750
disease of anatomical entity DOID:7 0 0.750
eye and adnexa disease DOID:1492 0 0.750
nervous system disease DOID:863 0 0.750
eye disease DOID:5614 0 0.750
retinitis pigmentosa DOID:10584 0 0.721
disease of cellular proliferation DOID:14566 0 0.297