Mus musculus

117 known processes

Klf4

Kruppel-like factor 4 (gut)

(Aliases: Gklf,EZF,Zie)

Klf4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cellular amine metabolic process GO:0033238 20 0.885
striated muscle tissue development GO:0014706 293 0.833
Mouse
fat cell differentiation GO:0045444 160 0.828
muscle tissue development GO:0060537 308 0.799
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.771
positive regulation of apoptotic process GO:0043065 217 0.757
amine metabolic process GO:0009308 45 0.738
regulation of fat cell differentiation GO:0045598 81 0.688
Mouse
myeloid cell differentiation GO:0030099 233 0.677
Mouse
regulation of cellular amino acid metabolic process GO:0006521 5 0.670
positive regulation of programmed cell death GO:0043068 218 0.644
camera type eye development GO:0043010 266 0.630
regulation of microvillus organization GO:0032530 3 0.614
Mouse
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.610
cardiac muscle hypertrophy in response to stress GO:0014898 10 0.602
Mouse
response to oxidative stress GO:0006979 123 0.581
axonogenesis GO:0007409 274 0.576
Mouse
regulation of cellular ketone metabolic process GO:0010565 66 0.538
lung development GO:0030324 164 0.536
Mouse
cellular ketone metabolic process GO:0042180 84 0.536
muscle system process GO:0003012 141 0.532
Mouse
blood vessel morphogenesis GO:0048514 285 0.529
Human Mouse
positive regulation of cell death GO:0010942 224 0.512
skeletal muscle cell differentiation GO:0035914 66 0.508
Mouse
skin development GO:0043588 220 0.495
nephron development GO:0072006 109 0.488
Mouse
cellular amino acid metabolic process GO:0006520 103 0.482
digestive tract morphogenesis GO:0048546 147 0.472
Human
skeletal muscle organ development GO:0060538 163 0.468
Mouse
regulation of protein serine threonine kinase activity GO:0071900 157 0.459
developmental maturation GO:0021700 193 0.452
Mouse
lung cell differentiation GO:0060479 30 0.435
Mouse
glial cell differentiation GO:0010001 131 0.416
Mouse
peptidyl lysine modification GO:0018205 77 0.408
Mouse
positive regulation of fat cell differentiation GO:0045600 32 0.394
Mouse
chromatin modification GO:0016568 187 0.393
Mouse
angiogenesis GO:0001525 201 0.390
Human Mouse
epidermis development GO:0008544 187 0.388
glomerulus development GO:0032835 40 0.369
Mouse
negative regulation of cellular amine metabolic process GO:0033239 1 0.358
negative regulation of cellular protein metabolic process GO:0032269 247 0.358
Human Mouse
response to organonitrogen compound GO:0010243 246 0.339
positive regulation of protein modification process GO:0031401 299 0.338
kidney development GO:0001822 213 0.335
Mouse
negative regulation of cell proliferation GO:0008285 296 0.335
stem cell development GO:0048864 219 0.325
cellular response to oxidative stress GO:0034599 76 0.322
respiratory system development GO:0060541 190 0.318
Mouse
stem cell maintenance GO:0019827 130 0.315
cellular amine metabolic process GO:0044106 44 0.315
negative regulation of protein metabolic process GO:0051248 282 0.315
Human Mouse
glomerular visceral epithelial cell differentiation GO:0072112 10 0.313
Mouse
epithelial cell proliferation GO:0050673 174 0.313
neuron projection guidance GO:0097485 141 0.306
Mouse
erythrocyte differentiation GO:0030218 88 0.302
Mouse
response to growth factor GO:0070848 198 0.300
Human
gastrulation GO:0007369 116 0.290
Human
peptidyl amino acid modification GO:0018193 336 0.290
Mouse
axon guidance GO:0007411 141 0.290
Mouse
digestive system development GO:0055123 200 0.289
Human Mouse
chromatin organization GO:0006325 206 0.287
Mouse
response to acid chemical GO:0001101 111 0.287
protein acylation GO:0043543 64 0.287
Mouse
renal system development GO:0072001 225 0.282
Mouse
cell differentiation involved in kidney development GO:0061005 33 0.281
Mouse
renal filtration cell differentiation GO:0061318 10 0.277
Mouse
glomerular epithelial cell differentiation GO:0072311 10 0.269
Mouse
gliogenesis GO:0042063 141 0.261
Mouse
negative regulation of protein modification process GO:0031400 163 0.259
Mouse
cellular response to cytokine stimulus GO:0071345 189 0.250
Mouse
gland development GO:0048732 330 0.250
Mouse
cytokine mediated signaling pathway GO:0019221 115 0.249
Mouse
digestive tract development GO:0048565 190 0.247
Human Mouse
response to inorganic substance GO:0010035 96 0.246
inflammatory response GO:0006954 244 0.240
cellular response to dna damage stimulus GO:0006974 207 0.237
placenta development GO:0001890 140 0.234
formation of primary germ layer GO:0001704 77 0.232
regulation of transferase activity GO:0051338 263 0.232
ameboidal type cell migration GO:0001667 128 0.232
Human
regulation of microvillus assembly GO:0032534 3 0.229
Mouse
negative regulation of molecular function GO:0044092 258 0.229
Human
mitotic cell cycle GO:0000278 195 0.226
regulation of organ morphogenesis GO:2000027 144 0.225
positive regulation of transcription from rna polymerase ii promoter in response to stress GO:0036003 3 0.223
mesoderm morphogenesis GO:0048332 64 0.220
nephron epithelium development GO:0072009 92 0.219
Mouse
type i pneumocyte differentiation GO:0060509 7 0.216
Mouse
apoptotic signaling pathway GO:0097190 306 0.214
regulation of inflammatory response GO:0050727 147 0.209
urogenital system development GO:0001655 261 0.208
Mouse
chemotaxis GO:0006935 247 0.206
Mouse
regulation of cellular component biogenesis GO:0044087 181 0.202
Mouse
mapk cascade GO:0000165 281 0.202
embryonic placenta development GO:0001892 98 0.200
regulation of leukocyte differentiation GO:1902105 159 0.199
regulation of kinase activity GO:0043549 249 0.195
positive regulation of myeloid leukocyte differentiation GO:0002763 26 0.193
regulation of cell cycle GO:0051726 281 0.193
regulation of dna templated transcription in response to stress GO:0043620 9 0.193
regulation of protein kinase activity GO:0045859 232 0.192
hepaticobiliary system development GO:0061008 67 0.184
Mouse
negative regulation of phosphate metabolic process GO:0045936 184 0.184
epithelial cell development GO:0002064 159 0.182
Mouse
dendrite development GO:0016358 115 0.179
Mouse
regulation of peptidyl lysine acetylation GO:2000756 22 0.176
Mouse
multicellular organism growth GO:0035264 161 0.169
Mouse
leukocyte differentiation GO:0002521 342 0.168
striated muscle adaptation GO:0014888 26 0.167
Mouse
cellular response to organic cyclic compound GO:0071407 87 0.165
t cell differentiation in thymus GO:0033077 77 0.163
regulation of cell projection organization GO:0031344 206 0.162
Mouse
positive regulation of protein phosphorylation GO:0001934 242 0.162
mitotic cell cycle process GO:1903047 159 0.161
central nervous system neuron development GO:0021954 67 0.160
cell type specific apoptotic process GO:0097285 268 0.159
positive regulation of cell development GO:0010720 237 0.156
ossification GO:0001503 216 0.156
striated muscle hypertrophy GO:0014897 24 0.155
Mouse
regulation of cell adhesion GO:0030155 154 0.155
Human
forebrain development GO:0030900 302 0.154
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.152
telencephalon development GO:0021537 186 0.150
purine containing compound metabolic process GO:0072521 311 0.150
muscle hypertrophy GO:0014896 24 0.150
Mouse
cell adhesion GO:0007155 329 0.149
Human
muscle cell differentiation GO:0042692 261 0.147
jnk cascade GO:0007254 72 0.145
regulation of epithelial cell proliferation GO:0050678 141 0.144
mesoderm formation GO:0001707 62 0.138
wound healing GO:0042060 157 0.137
regulation of fibroblast proliferation GO:0048145 34 0.137
positive regulation of protein kinase activity GO:0045860 144 0.137
cytokine production GO:0001816 319 0.133
Human
embryonic organ morphogenesis GO:0048562 276 0.131
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.131
homeostasis of number of cells GO:0048872 210 0.131
Mouse
negative regulation of protein phosphorylation GO:0001933 126 0.130
regulation of protein maturation GO:1903317 96 0.129
Human
cardiac muscle tissue development GO:0048738 130 0.127
regulation of neuron projection development GO:0010975 169 0.126
cell growth GO:0016049 130 0.125
hexose transport GO:0008645 56 0.124
Mouse
liver development GO:0001889 66 0.124
Mouse
peptidyl lysine acetylation GO:0018394 45 0.123
Mouse
protein maturation GO:0051604 176 0.122
Human
regulation of organelle organization GO:0033043 289 0.121
positive regulation of leukocyte differentiation GO:1902107 86 0.121
negative regulation of response to wounding GO:1903035 77 0.121
positive regulation of cellular amine metabolic process GO:0033240 5 0.119
negative regulation of fat cell differentiation GO:0045599 36 0.118
osteoclast differentiation GO:0030316 62 0.117
single organism cell adhesion GO:0098602 156 0.117
Human
regulation of peptidase activity GO:0052547 96 0.116
Human
negative regulation of protein processing GO:0010955 79 0.116
Human
myeloid leukocyte differentiation GO:0002573 119 0.114
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.113
regulation of ovulation GO:0060278 3 0.113
positive regulation of osteoclast differentiation GO:0045672 15 0.113
brown fat cell differentiation GO:0050873 36 0.113
negative regulation of phosphorylation GO:0042326 166 0.113
response to extracellular stimulus GO:0009991 127 0.112
positive regulation of nuclear transcribed mrna poly a tail shortening GO:0060213 4 0.111
carbohydrate transport GO:0008643 62 0.111
Mouse
regulation of cyclin dependent protein serine threonine kinase activity involved in g2 m transition of mitotic cell cycle GO:0031660 1 0.109
regulation of mapk cascade GO:0043408 248 0.109
cellular response to organonitrogen compound GO:0071417 145 0.109
regulation of apoptotic signaling pathway GO:2001233 197 0.108
response to organic cyclic compound GO:0014070 198 0.108
response to peptide GO:1901652 136 0.106
cell maturation GO:0048469 127 0.104
Mouse
regulation of myeloid leukocyte differentiation GO:0002761 58 0.103
regulation of chromosome organization GO:0033044 83 0.102
organ growth GO:0035265 117 0.101
cellular response to inorganic substance GO:0071241 37 0.100
adult behavior GO:0030534 135 0.100
negative regulation of cell fate specification GO:0009996 4 0.099
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.097
heart morphogenesis GO:0003007 178 0.097
regulation of anatomical structure size GO:0090066 178 0.096
sensory organ morphogenesis GO:0090596 242 0.096
cell substrate adhesion GO:0031589 130 0.095
cellular macromolecule catabolic process GO:0044265 206 0.094
kidney epithelium development GO:0072073 121 0.094
Mouse
regulation of cell motility GO:2000145 236 0.093
Human
covalent chromatin modification GO:0016569 163 0.093
regulation of histone modification GO:0031056 56 0.092
heterocycle catabolic process GO:0046700 280 0.092
regulation of neuron differentiation GO:0045664 281 0.092
response to transforming growth factor beta GO:0071559 88 0.091
developmental growth involved in morphogenesis GO:0060560 138 0.090
stem cell differentiation GO:0048863 268 0.090
ectodermal cell differentiation GO:0010668 3 0.090
bmp signaling pathway GO:0030509 93 0.090
cellular response to peptide GO:1901653 92 0.090
cellular response to extracellular stimulus GO:0031668 81 0.089
positive regulation of epithelial cell proliferation GO:0050679 68 0.089
regulation of map kinase activity GO:0043405 120 0.089
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.089
purine nucleoside catabolic process GO:0006152 205 0.088
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.088
regulation of cell activation GO:0050865 289 0.088
negative regulation of immune system process GO:0002683 209 0.088
lymphocyte differentiation GO:0030098 242 0.087
response to reactive oxygen species GO:0000302 56 0.085
regulation of membrane potential GO:0042391 192 0.084
central nervous system neuron differentiation GO:0021953 162 0.084
hippocampus development GO:0021766 52 0.083
cytoplasmic transport GO:0016482 234 0.083
chromatin remodeling GO:0006338 32 0.083
Mouse
t cell activation GO:0042110 289 0.082
regulation of cellular component size GO:0032535 121 0.082
regulation of defense response GO:0031347 233 0.082
cardiac muscle adaptation GO:0014887 10 0.081
Mouse
organophosphate catabolic process GO:0046434 232 0.081
epidermis morphogenesis GO:0048730 33 0.080
cellular response to calcium ion GO:0071277 14 0.080
cation transport GO:0006812 399 0.079
germ cell development GO:0007281 185 0.079
monosaccharide transport GO:0015749 58 0.079
Mouse
positive regulation of protein serine threonine kinase activity GO:0071902 106 0.079
macromolecule methylation GO:0043414 120 0.078
negative regulation of peptidase activity GO:0010466 46 0.078
Human
post embryonic organ development GO:0048569 17 0.077
female gamete generation GO:0007292 74 0.077
tissue migration GO:0090130 68 0.077
Human
regulation of cysteine type endopeptidase activity GO:2000116 65 0.077
Human
organic cyclic compound catabolic process GO:1901361 295 0.077
multicellular organismal homeostasis GO:0048871 164 0.076
regulation of stress activated mapk cascade GO:0032872 69 0.076
negative regulation of neuron apoptotic process GO:0043524 92 0.076
skin morphogenesis GO:0043589 38 0.076
locomotory behavior GO:0007626 195 0.076
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.076
regulation of hydrolase activity GO:0051336 246 0.076
Human
multi multicellular organism process GO:0044706 109 0.075
histone deacetylation GO:0016575 26 0.075
dna metabolic process GO:0006259 303 0.075
positive regulation of organelle organization GO:0010638 128 0.074
epithelial cell morphogenesis GO:0003382 41 0.074
regionalization GO:0003002 337 0.074
epithelial cell differentiation involved in kidney development GO:0035850 23 0.074
Mouse
labyrinthine layer blood vessel development GO:0060716 21 0.073
innate immune response GO:0045087 157 0.073
Worm
labyrinthine layer development GO:0060711 49 0.072
intestinal epithelial cell differentiation GO:0060575 14 0.072
Mouse
membrane lipid metabolic process GO:0006643 53 0.072
regulation of myeloid cell differentiation GO:0045637 96 0.072
regulation of response to wounding GO:1903034 189 0.072
endothelial cell migration GO:0043542 44 0.071
Human
cell fate commitment GO:0045165 210 0.071
neural precursor cell proliferation GO:0061351 121 0.070
cellular response to growth factor stimulus GO:0071363 197 0.070
Human
intestinal epithelial cell development GO:0060576 12 0.070
Mouse
negative regulation of defense response GO:0031348 77 0.070
positive regulation of cell migration GO:0030335 109 0.070
regulation of cellular response to stress GO:0080135 159 0.070
protein localization to nucleus GO:0034504 121 0.069
single organismal cell cell adhesion GO:0016337 131 0.069
Human
mitochondrion organization GO:0007005 134 0.068
ribonucleotide catabolic process GO:0009261 208 0.068
positive regulation of growth GO:0045927 104 0.068
protein localization to organelle GO:0033365 185 0.068
extrinsic apoptotic signaling pathway GO:0097191 126 0.068
vitellogenesis GO:0007296 2 0.068
positive regulation of cell cycle GO:0045787 92 0.067
mesenchymal cell development GO:0014031 93 0.067
cellular response to external stimulus GO:0071496 88 0.067
membrane organization GO:0061024 245 0.067
post embryonic camera type eye development GO:0031077 8 0.066
negative regulation of cysteine type endopeptidase activity GO:2000117 22 0.066
Human
aromatic compound catabolic process GO:0019439 286 0.066
ear development GO:0043583 200 0.065
establishment of protein localization to organelle GO:0072594 118 0.065
regulation of cell substrate adhesion GO:0010810 73 0.065
negative regulation of intracellular signal transduction GO:1902532 167 0.065
immune effector process GO:0002252 321 0.065
negative regulation of cell cycle GO:0045786 123 0.065
purine nucleotide metabolic process GO:0006163 302 0.065
positive regulation of fibroblast proliferation GO:0048146 20 0.064
skeletal system development GO:0001501 356 0.064
positive regulation of cellular catabolic process GO:0031331 148 0.064
negative regulation of phosphorus metabolic process GO:0010563 184 0.064
cellular chemical homeostasis GO:0055082 215 0.064
response to hydrogen peroxide GO:0042542 32 0.063
protein targeting GO:0006605 143 0.063
apoptotic mitochondrial changes GO:0008637 48 0.063
nucleobase containing small molecule metabolic process GO:0055086 352 0.063
regulation of cell projection assembly GO:0060491 38 0.062
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.062
regulation of establishment of protein localization GO:0070201 181 0.062
response to radiation GO:0009314 165 0.062
blastocyst development GO:0001824 80 0.062
positive regulation of mapk cascade GO:0043410 170 0.062
brain segmentation GO:0035284 3 0.061
regulation of cellular catabolic process GO:0031329 242 0.061
lung epithelium development GO:0060428 37 0.061
Mouse
regulation of leukocyte apoptotic process GO:2000106 56 0.061
negative regulation of protein maturation GO:1903318 79 0.061
Human
organelle fission GO:0048285 170 0.060
cellular nitrogen compound catabolic process GO:0044270 280 0.060
regulation of cell migration GO:0030334 219 0.060
Human
cellular response to gamma radiation GO:0071480 4 0.060
cognition GO:0050890 149 0.060
intracellular protein transport GO:0006886 204 0.060
axon regeneration GO:0031103 12 0.059
ear morphogenesis GO:0042471 118 0.059
cell matrix adhesion GO:0007160 68 0.058
neuron maturation GO:0042551 29 0.058
regulation of chromatin organization GO:1902275 57 0.058
positive regulation of kinase activity GO:0033674 155 0.058
regulation of protein processing GO:0070613 96 0.058
Human
regulation of muscle tissue development GO:1901861 97 0.057
fibroblast proliferation GO:0048144 35 0.057
regulation of homeostatic process GO:0032844 182 0.057
negative regulation of apoptotic signaling pathway GO:2001234 104 0.057
lung epithelial cell differentiation GO:0060487 29 0.057
Mouse
respiratory tube development GO:0030323 167 0.056
Mouse
positive regulation of transferase activity GO:0051347 167 0.056
regulation of intracellular transport GO:0032386 159 0.056
macromolecule deacylation GO:0098732 37 0.056
protein processing GO:0016485 163 0.056
Human
negative regulation of cellular component organization GO:0051129 194 0.055
positive regulation of cell morphogenesis involved in differentiation GO:0010770 72 0.055
glycosyl compound metabolic process GO:1901657 246 0.055
transforming growth factor beta2 production GO:0032906 2 0.054
regulation of chromatin modification GO:1903308 57 0.054
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.054
Human
compound eye development GO:0048749 1 0.054
organonitrogen compound biosynthetic process GO:1901566 192 0.053
stress activated protein kinase signaling cascade GO:0031098 81 0.053
histone modification GO:0016570 159 0.053
response to light stimulus GO:0009416 135 0.053
neuron apoptotic process GO:0051402 142 0.053
central nervous system projection neuron axonogenesis GO:0021952 21 0.052
morphogenesis of a branching structure GO:0001763 203 0.052
positive regulation of myeloid cell differentiation GO:0045639 43 0.052
positive regulation of cell motility GO:2000147 116 0.052
response to lipopolysaccharide GO:0032496 128 0.051
response to molecule of bacterial origin GO:0002237 143 0.051
skeletal system morphogenesis GO:0048705 203 0.051
epithelial to mesenchymal transition GO:0001837 47 0.051
rhombomere 5 development GO:0021571 4 0.051
cellular homeostasis GO:0019725 240 0.051
positive regulation of nucleocytoplasmic transport GO:0046824 30 0.050
transmission of nerve impulse GO:0019226 76 0.050
central nervous system segmentation GO:0035283 3 0.050
nitrogen compound transport GO:0071705 271 0.050
nuclear division GO:0000280 158 0.050
synaptic transmission GO:0007268 329 0.050
single organism nuclear import GO:1902593 95 0.049
regulation of nucleotide metabolic process GO:0006140 169 0.049
cell fate specification GO:0001708 72 0.049
intrinsic apoptotic signaling pathway GO:0097193 132 0.049
protein polymerization GO:0051258 57 0.049
protein methylation GO:0006479 81 0.049
regulation of ossification GO:0030278 112 0.049
nucleocytoplasmic transport GO:0006913 139 0.049
regulation of osteoblast differentiation GO:0045667 67 0.048
muscle adaptation GO:0043500 39 0.048
Mouse
male gamete generation GO:0048232 285 0.048
actin cytoskeleton organization GO:0030036 220 0.048
blood circulation GO:0008015 195 0.048
regulation of osteoclast differentiation GO:0045670 36 0.048
regulation of nucleoside metabolic process GO:0009118 130 0.048
neuron death GO:0070997 154 0.048
regulation of protein transport GO:0051223 163 0.048
regulation of protein deacetylation GO:0090311 17 0.048
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 62 0.047
Human
dna repair GO:0006281 107 0.047
nucleotide catabolic process GO:0009166 217 0.047
cellular response to hormone stimulus GO:0032870 150 0.046
mesoderm development GO:0007498 100 0.046
purine ribonucleotide metabolic process GO:0009150 290 0.046
positive regulation of map kinase activity GO:0043406 84 0.046
inner ear morphogenesis GO:0042472 101 0.045
neuronal action potential GO:0019228 54 0.045
regulation of cellular response to growth factor stimulus GO:0090287 82 0.045
wnt signaling pathway GO:0016055 188 0.045
positive regulation of cell activation GO:0050867 158 0.045
response to endoplasmic reticulum stress GO:0034976 53 0.044
negative regulation of hydrolase activity GO:0051346 71 0.044
Human
nuclear transport GO:0051169 139 0.044
positive regulation of neuron differentiation GO:0045666 141 0.044
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.044
positive regulation of ossification GO:0045778 47 0.044
nucleotide metabolic process GO:0009117 332 0.044
embryonic hemopoiesis GO:0035162 23 0.044
Mouse
rhythmic process GO:0048511 174 0.043
regulation of binding GO:0051098 111 0.043
regulation of brown fat cell differentiation GO:0090335 5 0.043
response to retinoic acid GO:0032526 56 0.043
divalent metal ion transport GO:0070838 172 0.043
posttranscriptional regulation of gene expression GO:0010608 155 0.043
cardiac chamber morphogenesis GO:0003206 93 0.042
regulation of stem cell differentiation GO:2000736 50 0.042
regulation of bmp signaling pathway GO:0030510 60 0.042
muscle contraction GO:0006936 101 0.042
ribonucleoside metabolic process GO:0009119 245 0.042
response to oxygen levels GO:0070482 62 0.041
protein alkylation GO:0008213 81 0.041
response to ionizing radiation GO:0010212 42 0.041
response to fluid shear stress GO:0034405 7 0.041
Human
microglial cell activation GO:0001774 3 0.041
keratinocyte differentiation GO:0030216 48 0.041
regulation of protein localization GO:0032880 231 0.040
canonical wnt signaling pathway GO:0060070 130 0.040
negative regulation of ovulation GO:0060280 1 0.040
actin filament organization GO:0007015 113 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 88 0.039
transmembrane transport GO:0055085 412 0.039
circulatory system process GO:0003013 197 0.039
peptidyl serine phosphorylation GO:0018105 74 0.039
methylation GO:0032259 134 0.039
regulation of neuron apoptotic process GO:0043523 122 0.039
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.039
regulation of lipid metabolic process GO:0019216 118 0.039
organonitrogen compound catabolic process GO:1901565 264 0.039
cellular response to radiation GO:0071478 28 0.039
oocyte differentiation GO:0009994 35 0.039
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 40 0.038
Human
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.038
purine nucleotide catabolic process GO:0006195 211 0.038
regulation of vasculature development GO:1901342 88 0.038
Human
regulation of neural precursor cell proliferation GO:2000177 70 0.038
ribonucleotide metabolic process GO:0009259 291 0.038
response to nutrient levels GO:0031667 109 0.038
activation of mapk activity GO:0000187 59 0.038
limbic system development GO:0021761 72 0.038
sensory perception GO:0007600 245 0.038
regulation of system process GO:0044057 200 0.038
cellular response to starvation GO:0009267 57 0.038
negative regulation of epithelial cell proliferation GO:0050680 64 0.037
circadian rhythm GO:0007623 114 0.037
peptidyl tyrosine phosphorylation GO:0018108 143 0.037
cellular ion homeostasis GO:0006873 165 0.037
negative regulation of cytokine production GO:0001818 84 0.037
Human
epithelial cell migration GO:0010631 63 0.037
Human
morphogenesis of a branching epithelium GO:0061138 193 0.037
cellular response to lipid GO:0071396 145 0.037
ureteric bud development GO:0001657 94 0.036
ribonucleoside catabolic process GO:0042454 206 0.036
negative regulation of mapk cascade GO:0043409 65 0.036
ovulation GO:0030728 15 0.036
small gtpase mediated signal transduction GO:0007264 97 0.036
negative regulation of mesoderm development GO:2000381 8 0.036
regulation of nucleocytoplasmic transport GO:0046822 73 0.036
endocytosis GO:0006897 168 0.036
protein import into nucleus GO:0006606 95 0.036
negative regulation of transcription from rna polymerase ii promoter in response to stress GO:0097201 1 0.036
kidney mesenchyme morphogenesis GO:0072131 4 0.036
metal ion homeostasis GO:0055065 189 0.035
spermatogenesis GO:0007283 284 0.035
fertilization GO:0009566 127 0.035
regulation of ras protein signal transduction GO:0046578 114 0.035
cellular metal ion homeostasis GO:0006875 151 0.035
adult locomotory behavior GO:0008344 91 0.035
regulation of sphingolipid biosynthetic process GO:0090153 1 0.035
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.035
developmental cell growth GO:0048588 84 0.035
chondrocyte differentiation GO:0002062 72 0.035
cellular response to fluid shear stress GO:0071498 4 0.035
Human
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.035
regulation of lymphocyte activation GO:0051249 240 0.035
glycosyl compound catabolic process GO:1901658 206 0.034
somatic stem cell maintenance GO:0035019 47 0.034
heart contraction GO:0060047 93 0.034
regulation of cytoplasmic transport GO:1903649 112 0.034
neuron projection regeneration GO:0031102 14 0.034
positive regulation of histone modification GO:0031058 28 0.034
connective tissue development GO:0061448 179 0.034
positive regulation of phospholipase activity GO:0010518 3 0.034
leukocyte apoptotic process GO:0071887 71 0.034
regulation of chondrocyte differentiation GO:0032330 33 0.034
negative regulation of inflammatory response GO:0050728 61 0.034
regulation of ion transport GO:0043269 215 0.034
metanephros development GO:0001656 79 0.034
sensory system development GO:0048880 3 0.034
regulation of endothelial cell proliferation GO:0001936 23 0.033
heart process GO:0003015 94 0.033
mesenchymal cell differentiation GO:0048762 107 0.033
endomembrane system organization GO:0010256 147 0.033
regulation of smad protein import into nucleus GO:0060390 3 0.033
purine ribonucleoside catabolic process GO:0046130 205 0.033
microtubule cytoskeleton organization GO:0000226 157 0.033

Klf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.090
disease of cellular proliferation DOID:14566 0 0.090
organ system cancer DOID:0050686 0 0.090
muscular disease DOID:0080000 0 0.081
disease of anatomical entity DOID:7 0 0.081
musculoskeletal system disease DOID:17 0 0.081
immune system disease DOID:2914 0 0.069
myopathy DOID:423 0 0.052
heart disease DOID:114 0 0.052
cardiomyopathy DOID:0050700 0 0.052
intrinsic cardiomyopathy DOID:0060036 0 0.052
cardiovascular system disease DOID:1287 0 0.052
muscle tissue disease DOID:66 0 0.052
hematopoietic system disease DOID:74 0 0.042