Mus musculus

186 known processes

Kras

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

(Aliases: Kras-2,p21B,Kras2,Ki-ras,MGC7141,AI929937,ras,K-ras)

Kras biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
oocyte axis specification GO:0007309 2 1.000
Fly
macroautophagy GO:0016236 21 1.000
Fly
regulation of autophagy GO:0010506 30 0.999
Fly
negative regulation of fibroblast migration GO:0010764 2 0.999
regulation of kinase activity GO:0043549 249 0.999
Rat
negative regulation of synaptic vesicle exocytosis GO:2000301 3 0.998
oocyte differentiation GO:0009994 35 0.998
Fly
regulation of cell cycle GO:0051726 281 0.998
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.998
Worm
negative regulation of neuron apoptotic process GO:0043524 92 0.997
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 9 0.996
ras protein signal transduction GO:0007265 77 0.996
actin filament organization GO:0007015 113 0.995
protein autophosphorylation GO:0046777 61 0.995
visual behavior GO:0007632 45 0.995
actin cytoskeleton organization GO:0030036 220 0.995
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 16 0.995
negative regulation of synaptic vesicle transport GO:1902804 3 0.994
oocyte construction GO:0007308 2 0.994
Fly
negative regulation of organ growth GO:0046621 17 0.993
regionalization GO:0003002 337 0.992
Fly
cellular response to dna damage stimulus GO:0006974 207 0.992
regulation of ras protein signal transduction GO:0046578 114 0.992
regulation of neuron apoptotic process GO:0043523 122 0.991
intrinsic apoptotic signaling pathway GO:0097193 132 0.990
Mouse
regulation of synaptic plasticity GO:0048167 87 0.989
autophagy GO:0006914 45 0.989
Fly
negative regulation of protein phosphorylation GO:0001933 126 0.988
cellular response to growth factor stimulus GO:0071363 197 0.988
negative regulation of cell cycle GO:0045786 123 0.988
regulation of protein stability GO:0031647 52 0.987
response to light stimulus GO:0009416 135 0.987
purine containing compound biosynthetic process GO:0072522 70 0.986
Yeast
homeostasis of number of cells GO:0048872 210 0.986
Fly
respiratory tube development GO:0030323 167 0.984
negative regulation of neurotransmitter secretion GO:0046929 5 0.982
regulation of cellular amino acid metabolic process GO:0006521 5 0.982
negative regulation of macroautophagy GO:0016242 5 0.981
Fly
gastrulation GO:0007369 116 0.981
Fly
apoptotic signaling pathway GO:0097190 306 0.980
Mouse Fly
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 34 0.979
regulation of cellular amine metabolic process GO:0033238 20 0.978
striated muscle tissue development GO:0014706 293 0.977
Mouse
digestive tract development GO:0048565 190 0.976
Fly
germ cell development GO:0007281 185 0.974
Worm Fly
cell growth GO:0016049 130 0.971
Yeast Fly
mitotic cell cycle GO:0000278 195 0.968
embryonic organ morphogenesis GO:0048562 276 0.968
Zebrafish
positive regulation of mitotic sister chromatid separation GO:1901970 2 0.968
axon guidance GO:0007411 141 0.966
negative regulation of autophagy GO:0010507 9 0.966
Fly
purine ribonucleotide metabolic process GO:0009150 290 0.966
visual learning GO:0008542 44 0.965
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 13 0.964
negative regulation of cell motility GO:2000146 61 0.961
Mouse
dna metabolic process GO:0006259 303 0.960
regulation of mitotic cell cycle GO:0007346 126 0.960
regulation of cellular ketone metabolic process GO:0010565 66 0.959
ribonucleoside metabolic process GO:0009119 245 0.959
pole plasm assembly GO:0007315 2 0.958
stem cell development GO:0048864 219 0.958
cell adhesion GO:0007155 329 0.956
negative regulation of cell proliferation GO:0008285 296 0.955
axonogenesis GO:0007409 274 0.955
lung development GO:0030324 164 0.955
regulation of transferase activity GO:0051338 263 0.954
Rat
signal transduction by p53 class mediator GO:0072331 51 0.954
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 35 0.953
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 45 0.952
regulation of macroautophagy GO:0016241 12 0.950
Fly
small gtpase mediated signal transduction GO:0007264 97 0.948
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 43 0.948
negative regulation of epithelial cell proliferation GO:0050680 64 0.947
positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 1 0.947
intermediate filament based process GO:0045103 27 0.947
ribonucleotide metabolic process GO:0009259 291 0.946
cellular response to transforming growth factor beta stimulus GO:0071560 88 0.943
mapk cascade GO:0000165 281 0.942
Rat Fly
gland development GO:0048732 330 0.942
positive regulation of cell development GO:0010720 237 0.937
Fly
oogenesis GO:0048477 56 0.935
Worm Fly
gliogenesis GO:0042063 141 0.935
Fly
cellular amine metabolic process GO:0044106 44 0.934
cellular ketone metabolic process GO:0042180 84 0.934
regulation of protein kinase activity GO:0045859 232 0.932
Rat
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 194 0.931
long term synaptic potentiation GO:0060291 25 0.930
positive regulation of transcription by galactose GO:0000411 1 0.930
Yeast
peptidyl amino acid modification GO:0018193 336 0.929
chemotaxis GO:0006935 247 0.929
stem cell differentiation GO:0048863 268 0.927
Fly
negative regulation of phosphorylation GO:0042326 166 0.927
response to radiation GO:0009314 165 0.926
response to nutrient levels GO:0031667 109 0.926
Yeast Fly
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 23 0.924
carbon catabolite regulation of transcription GO:0045990 4 0.920
Yeast
response to extracellular stimulus GO:0009991 127 0.918
Yeast Fly
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 11 0.917
cellular response to extracellular stimulus GO:0031668 81 0.917
Yeast Fly
female gamete generation GO:0007292 74 0.915
Worm Fly
neuron projection guidance GO:0097485 141 0.914
epidermal growth factor receptor signaling pathway GO:0007173 28 0.914
Worm
cell type specific apoptotic process GO:0097285 268 0.910
nucleobase containing small molecule metabolic process GO:0055086 352 0.909
negative regulation of growth GO:0045926 99 0.908
negative regulation of mitotic cell cycle GO:0045930 58 0.907
negative regulation of ras protein signal transduction GO:0046580 18 0.904
nucleoside phosphate biosynthetic process GO:1901293 79 0.904
Yeast
negative regulation of transcription involved in g1 s transition of mitotic cell cycle GO:0071930 1 0.899
negative regulation of cellular amine metabolic process GO:0033239 1 0.899
establishment of organelle localization GO:0051656 122 0.899
associative learning GO:0008306 61 0.899
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 43 0.895
regulation of cellular response to stress GO:0080135 159 0.894
Fly
cellular response to drug GO:0035690 15 0.893
cellular response to external stimulus GO:0071496 88 0.892
Yeast Fly
neuron apoptotic process GO:0051402 142 0.891
regulation of neuronal synaptic plasticity GO:0048168 30 0.890
purine ribonucleoside metabolic process GO:0046128 241 0.889
t cell activation GO:0042110 289 0.889
intra s dna damage checkpoint GO:0031573 4 0.885
response to insulin GO:0032868 100 0.885
regulation of ras gtpase activity GO:0032318 88 0.884
Worm
regulation of cell morphogenesis involved in differentiation GO:0010769 151 0.883
nucleoside phosphate catabolic process GO:1901292 222 0.882
regulation of cell adhesion GO:0030155 154 0.881
cellular nitrogen compound catabolic process GO:0044270 280 0.881
negative regulation of protein serine threonine kinase activity GO:0071901 49 0.877
glycosyl compound metabolic process GO:1901657 246 0.872
negative regulation of rho protein signal transduction GO:0035024 7 0.870
activation of mapkk activity GO:0000186 15 0.870
positive regulation of ras protein signal transduction GO:0046579 13 0.867
negative regulation of cell cycle phase transition GO:1901988 48 0.866
intermediate filament cytoskeleton organization GO:0045104 26 0.866
response to starvation GO:0042594 65 0.865
Fly
cell substrate adhesion GO:0031589 130 0.865
stem cell proliferation GO:0072089 117 0.861
Fly
glycosyl compound catabolic process GO:1901658 206 0.861
oocyte development GO:0048599 33 0.861
Fly
positive regulation of mitotic metaphase anaphase transition GO:0045842 2 0.860
regulation of muscle tissue development GO:1901861 97 0.858
Mouse
regulation of mitotic cell cycle phase transition GO:1901990 73 0.856
learning GO:0007612 98 0.855
negative regulation of apoptotic signaling pathway GO:2001234 104 0.853
Fly
cellular amino acid metabolic process GO:0006520 103 0.849
neural fold elevation formation GO:0021502 1 0.844
response to growth factor GO:0070848 198 0.844
cell cycle arrest GO:0007050 37 0.843
nucleotide biosynthetic process GO:0009165 78 0.841
Yeast
ribonucleoside catabolic process GO:0042454 206 0.841
negative regulation of glial cell proliferation GO:0060253 4 0.840
regulation of mapk cascade GO:0043408 248 0.832
Rat Fly
segmentation GO:0035282 93 0.829
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 31 0.828
rap protein signal transduction GO:0032486 3 0.828
regulation of smad protein import into nucleus GO:0060390 3 0.827
spermatid differentiation GO:0048515 115 0.826
skeletal muscle organ development GO:0060538 163 0.824
Mouse
cellular response to starvation GO:0009267 57 0.822
Fly
muscle cell differentiation GO:0042692 261 0.819
photoreceptor cell morphogenesis GO:0008594 3 0.818
Fly
myeloid cell differentiation GO:0030099 233 0.817
cardiac endothelial cell differentiation GO:0003348 4 0.817
ameboidal type cell migration GO:0001667 128 0.814
Fly
negative regulation of cell migration GO:0030336 59 0.814
Mouse
carbon catabolite activation of transcription GO:0045991 4 0.814
Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.812
regulation of cell substrate adhesion GO:0010810 73 0.803
dna damage checkpoint GO:0000077 26 0.803
dendrite development GO:0016358 115 0.803
purine ribonucleotide biosynthetic process GO:0009152 59 0.801
Yeast
mitotic cell cycle process GO:1903047 159 0.801
regulation of cardiac muscle cell proliferation GO:0060043 23 0.801
hypoxia inducible factor 1alpha signaling pathway GO:0097411 2 0.800
negative regulation of protein depolymerization GO:1901880 21 0.800
blood vessel morphogenesis GO:0048514 285 0.798
positive regulation of apoptotic signaling pathway GO:2001235 95 0.795
mitotic g1 dna damage checkpoint GO:0031571 4 0.790
neuron death GO:0070997 154 0.789
negative regulation of protein metabolic process GO:0051248 282 0.785
negative regulation of cellular catabolic process GO:0031330 47 0.785
Fly
positive regulation of kinase activity GO:0033674 155 0.785
Rat
regulation of long term neuronal synaptic plasticity GO:0048169 19 0.785
signal transduction involved in dna integrity checkpoint GO:0072401 3 0.784
genetic imprinting GO:0071514 27 0.783
epithelial tube morphogenesis GO:0060562 303 0.780
embryonic placenta development GO:0001892 98 0.779
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 24 0.775
Yeast
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 3 0.775
maternal process involved in female pregnancy GO:0060135 32 0.774
neuronal action potential GO:0019228 54 0.773
tor signaling GO:0031929 21 0.770
Fly
regulation of cell cycle phase transition GO:1901987 77 0.767
cardiac muscle tissue growth GO:0055017 37 0.765
guanosine containing compound catabolic process GO:1901069 144 0.764
regulation of purine nucleotide metabolic process GO:1900542 169 0.764
Yeast Worm
cell aging GO:0007569 35 0.760
Yeast Mouse
protein modification by small protein conjugation or removal GO:0070647 207 0.756
regulation of protein serine threonine kinase activity GO:0071900 157 0.753
Rat
exocytosis GO:0006887 121 0.750
regulation of neuron death GO:1901214 134 0.748
intracellular signal transduction involved in g1 dna damage checkpoint GO:1902400 3 0.747
purine nucleotide biosynthetic process GO:0006164 65 0.747
Yeast
carbohydrate derivative catabolic process GO:1901136 231 0.745
negative regulation of neuron death GO:1901215 98 0.745
regulation of cytoskeleton organization GO:0051493 122 0.743
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 4 0.741
transforming growth factor beta receptor signaling pathway GO:0007179 71 0.735
microtubule polymerization or depolymerization GO:0031109 26 0.732
positive regulation of ras gtpase activity GO:0032320 65 0.732
Worm
organonitrogen compound catabolic process GO:1901565 264 0.731
heart morphogenesis GO:0003007 178 0.731
ion transmembrane transport GO:0034220 361 0.731
positive regulation of apoptotic process GO:0043065 217 0.730
leukocyte differentiation GO:0002521 342 0.728
negative regulation of dna replication GO:0008156 4 0.727
meiotic chromosome segregation GO:0045132 19 0.725
extrinsic apoptotic signaling pathway GO:0097191 126 0.724
response to ionizing radiation GO:0010212 42 0.717
positive t cell selection GO:0043368 23 0.716
positive regulation of cellular amine metabolic process GO:0033240 5 0.715
dna damage response signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 2 0.714
negative regulation of t cell proliferation GO:0042130 38 0.714
positive regulation of bmp signaling pathway GO:0030513 23 0.714
negative regulation of cell growth GO:0030308 44 0.712
regulation of cellular response to growth factor stimulus GO:0090287 82 0.711
regulation of sequence specific dna binding transcription factor activity GO:0051090 106 0.711
Rat
regulation of cellular component biogenesis GO:0044087 181 0.705
positive regulation of actin filament bundle assembly GO:0032233 11 0.703
regulation of vasculature development GO:1901342 88 0.699
mesenchymal cell differentiation GO:0048762 107 0.695
central nervous system neuron differentiation GO:0021953 162 0.695
positive regulation of rap gtpase activity GO:0032854 3 0.694
Worm
leukocyte proliferation GO:0070661 172 0.691
dna damage response signal transduction by p53 class mediator GO:0030330 19 0.688
multicellular organism growth GO:0035264 161 0.686
Fly
regulation of apoptotic signaling pathway GO:2001233 197 0.680
Fly
regulation of cell cycle process GO:0010564 160 0.678
regulation of cell size GO:0008361 72 0.677
Fly
positive regulation of nucleoside metabolic process GO:0045979 91 0.676
Worm
regulation of synaptic vesicle exocytosis GO:2000300 11 0.671
regulation of osteoclast differentiation GO:0045670 36 0.669
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 4 0.666
cognition GO:0050890 149 0.665
erythrocyte differentiation GO:0030218 88 0.659
somite specification GO:0001757 4 0.658
regulation of cardiac muscle tissue growth GO:0055021 26 0.649
negative regulation of intracellular signal transduction GO:1902532 167 0.649
positive regulation of stress fiber assembly GO:0051496 9 0.643
negative regulation of cellular protein metabolic process GO:0032269 247 0.642
respiratory system development GO:0060541 190 0.635
osteoclast differentiation GO:0030316 62 0.634
posttranscriptional regulation of gene expression GO:0010608 155 0.630
regulation of myeloid cell differentiation GO:0045637 96 0.630
endothelial cell apoptotic process GO:0072577 9 0.628
nucleoside metabolic process GO:0009116 246 0.626
regulation of organelle organization GO:0033043 289 0.623
response to peptide GO:1901652 136 0.622
cellular lipid metabolic process GO:0044255 323 0.620
guanosine containing compound metabolic process GO:1901068 144 0.620
regulation of epithelial cell proliferation involved in prostate gland development GO:0060768 10 0.619
regulation of nucleoside metabolic process GO:0009118 130 0.618
Worm
regulation of cardiac cell fate specification GO:2000043 1 0.618
activation of adenylate cyclase activity GO:0007190 4 0.614
Yeast
lymphocyte differentiation GO:0030098 242 0.613
epithelial cell proliferation GO:0050673 174 0.613
negative regulation of cell substrate adhesion GO:0010812 16 0.612
positive regulation of cell adhesion GO:0045785 80 0.611
amine metabolic process GO:0009308 45 0.608
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.606
purine containing compound metabolic process GO:0072521 311 0.604
digestive system development GO:0055123 200 0.604
Fly
regulation of actin filament bundle assembly GO:0032231 18 0.603
cation transport GO:0006812 399 0.602
regulation of photoreceptor cell differentiation GO:0046532 4 0.601
Fly
nuclear transport GO:0051169 139 0.601
Fly
cell fate commitment GO:0045165 210 0.601
Worm Fly
mesenchyme development GO:0060485 152 0.596
purine ribonucleoside catabolic process GO:0046130 205 0.591
negative regulation of endothelial cell apoptotic process GO:2000352 7 0.589
cellular response to peptide hormone stimulus GO:0071375 92 0.588
heterocycle catabolic process GO:0046700 280 0.588
cellular response to nutrient levels GO:0031669 64 0.588
Yeast Fly
nucleotide catabolic process GO:0009166 217 0.585
heart growth GO:0060419 45 0.584
embryonic hemopoiesis GO:0035162 23 0.584
Fly
regulation of keratinocyte differentiation GO:0045616 11 0.580
muscle tissue development GO:0060537 308 0.578
Mouse
microtubule polymerization GO:0046785 12 0.577
development of primary sexual characteristics GO:0045137 143 0.575
Worm
myeloid leukocyte differentiation GO:0002573 119 0.573
cell growth involved in cardiac muscle cell development GO:0061049 3 0.573
negative regulation of neurotransmitter transport GO:0051589 7 0.570
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 22 0.567
urogenital system development GO:0001655 261 0.567
Fly
regulation of myeloid leukocyte differentiation GO:0002761 58 0.563
b cell differentiation GO:0030183 78 0.563
determination of adult lifespan GO:0008340 11 0.561
negative regulation of immature t cell proliferation GO:0033087 3 0.559
regulation of jak stat cascade GO:0046425 34 0.557
striated muscle cell proliferation GO:0014855 39 0.557
negative regulation of leukocyte differentiation GO:1902106 51 0.555
lactation GO:0007595 25 0.553
negative regulation of dendritic spine morphogenesis GO:0061002 3 0.552
protein targeting GO:0006605 143 0.552
Fly
vesicle localization GO:0051648 86 0.550
phosphatidylinositol metabolic process GO:0046488 45 0.548
positive regulation of nervous system development GO:0051962 221 0.548
Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 112 0.547
negative regulation of cellular amino acid metabolic process GO:0045763 0 0.547
cellular response to vitamin GO:0071295 2 0.545
purine nucleoside metabolic process GO:0042278 241 0.543
nucleoside phosphate metabolic process GO:0006753 338 0.541
regulation of reactive oxygen species metabolic process GO:2000377 40 0.541
cellular response to lipid GO:0071396 145 0.539
positive regulation of programmed cell death GO:0043068 218 0.537
negative regulation of kinase activity GO:0033673 81 0.536
regulation of cellular component size GO:0032535 121 0.536
Fly
g1 s transition of mitotic cell cycle GO:0000082 57 0.536
positive regulation of cellular catabolic process GO:0031331 148 0.532
Worm
epithelial tube branching involved in lung morphogenesis GO:0060441 28 0.529
negative regulation of phosphate metabolic process GO:0045936 184 0.528
regulation of cell motility GO:2000145 236 0.527
Mouse
regulation of microtubule polymerization GO:0031113 7 0.526
camp biosynthetic process GO:0006171 31 0.522
Yeast
negative regulation of bmp signaling pathway GO:0030514 35 0.522
ribonucleotide biosynthetic process GO:0009260 59 0.519
Yeast
stem cell maintenance GO:0019827 130 0.519
regulation of transmembrane transport GO:0034762 128 0.518
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.518
purine nucleoside catabolic process GO:0006152 205 0.518
mitochondrial dna repair GO:0043504 3 0.516
peptidyl serine modification GO:0018209 83 0.515
regulation of anatomical structure size GO:0090066 178 0.515
Fly
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.514
cardiac muscle tissue development GO:0048738 130 0.511
receptor biosynthetic process GO:0032800 3 0.511
body fluid secretion GO:0007589 53 0.510
regulation of chemotaxis GO:0050920 53 0.509
negative regulation of protein modification process GO:0031400 163 0.509
cell maturation GO:0048469 127 0.509
Fly
regulation of bmp signaling pathway GO:0030510 60 0.509
peptidyl serine phosphorylation GO:0018105 74 0.505
negative regulation of phosphatidylinositol 3 kinase activity GO:0043553 1 0.505
carbohydrate derivative biosynthetic process GO:1901137 183 0.505
Yeast
g protein coupled receptor signaling pathway GO:0007186 243 0.505
Yeast
branching morphogenesis of an epithelial tube GO:0048754 159 0.504
forebrain development GO:0030900 302 0.503
positive regulation of proteolysis GO:0045862 85 0.503
gtp catabolic process GO:0006184 143 0.503
appendage development GO:0048736 166 0.500
Fly
positive regulation of macroautophagy GO:0016239 3 0.500
keratinocyte differentiation GO:0030216 48 0.498
regulation of canonical wnt signaling pathway GO:0060828 82 0.497
columnar cuboidal epithelial cell differentiation GO:0002065 82 0.496
Fly
metanephric glomerular mesangium development GO:0072223 3 0.493
regulation of gliogenesis GO:0014013 50 0.492
regulation of epidermal growth factor receptor signaling pathway GO:0042058 13 0.490
protein kinase b signaling GO:0043491 74 0.490
canonical wnt signaling pathway involved in positive regulation of apoptotic process GO:0044337 3 0.488
muscle cell proliferation GO:0033002 52 0.484
purine ribonucleotide catabolic process GO:0009154 208 0.484
positive regulation of nucleotide metabolic process GO:0045981 114 0.481
Yeast Worm
positive regulation of rac protein signal transduction GO:0035022 1 0.481
dna integrity checkpoint GO:0031570 28 0.479
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 8 0.477
response to metal ion GO:0010038 47 0.477
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 6 0.476
regulation of epithelial cell proliferation GO:0050678 141 0.476
regulation of cell projection organization GO:0031344 206 0.476
Worm
immune effector process GO:0002252 321 0.470
cellular response to organic cyclic compound GO:0071407 87 0.467
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 4 0.465
response to oxidative stress GO:0006979 123 0.465
cellular protein catabolic process GO:0044257 155 0.463
positive regulation of wound healing GO:0090303 17 0.462
positive regulation of protein modification process GO:0031401 299 0.462
Human Rat
rho protein signal transduction GO:0007266 32 0.461
aromatic compound catabolic process GO:0019439 286 0.459
organ growth GO:0035265 117 0.459
positive regulation of leukocyte differentiation GO:1902107 86 0.459
b 1 b cell homeostasis GO:0001922 4 0.458
regulation of rac protein signal transduction GO:0035020 19 0.458
gtp metabolic process GO:0046039 144 0.457
blastoderm segmentation GO:0007350 13 0.456
nucleotide metabolic process GO:0009117 332 0.455
spermatogenesis GO:0007283 284 0.454
clara cell differentiation GO:0060486 4 0.454
multicellular organismal aging GO:0010259 24 0.453
organelle localization GO:0051640 179 0.453
negative regulation of thymocyte apoptotic process GO:0070244 8 0.449
regulation of microtubule polymerization or depolymerization GO:0031110 20 0.444
positive regulation of purine nucleotide metabolic process GO:1900544 114 0.443
Yeast Worm
regulation of ion transmembrane transport GO:0034765 119 0.441
positive regulation of hydrolase activity GO:0051345 148 0.439
Worm
positive regulation of cell death GO:0010942 224 0.436
negative regulation of tor signaling GO:0032007 13 0.436
regulation of nucleotide metabolic process GO:0006140 169 0.436
Yeast Worm
regulation of protein depolymerization GO:1901879 26 0.434
metaphase plate congression GO:0051310 2 0.432
positive regulation of cytoskeleton organization GO:0051495 49 0.425
regulation of lymphocyte proliferation GO:0050670 117 0.423
mitotic cell cycle arrest GO:0071850 4 0.422
formation of organ boundary GO:0010160 1 0.421
response to nutrient GO:0007584 12 0.420
Yeast
protein modification by small protein conjugation GO:0032446 187 0.418
negative regulation of mitotic cell cycle phase transition GO:1901991 45 0.417
protein catabolic process GO:0030163 221 0.415
regulation of hydrolase activity GO:0051336 246 0.414
Worm
establishment of vesicle localization GO:0051650 81 0.412
epithelial to mesenchymal transition GO:0001837 47 0.410
meiotic cell cycle process GO:1903046 77 0.410
Yeast
regulation of dna templated transcription in response to stress GO:0043620 9 0.409
cell proliferation involved in heart valve morphogenesis GO:0003249 1 0.407
digestive tract morphogenesis GO:0048546 147 0.406
Fly
regulation of cell migration GO:0030334 219 0.405
Mouse
dendrite regeneration GO:0031104 1 0.404
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 61 0.402
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 2 0.401
purine containing compound catabolic process GO:0072523 213 0.400
mesenchymal cell development GO:0014031 93 0.398
stem cell fate commitment GO:0048865 5 0.396
Fly
odontogenesis GO:0042476 78 0.396
mesoderm development GO:0007498 100 0.394
regulation of cyclic nucleotide metabolic process GO:0030799 40 0.392
Yeast
regulation of exocytosis GO:0017157 61 0.390
positive regulation of mapk cascade GO:0043410 170 0.389
Rat Fly
positive regulation of transcription from rna polymerase ii promoter involved in smooth muscle cell differentiation GO:2000721 2 0.388
sprouting angiogenesis GO:0002040 26 0.388
regulation of neuron differentiation GO:0045664 281 0.385
Fly
establishment of synaptic vesicle localization GO:0097480 57 0.383
regulation of stem cell differentiation GO:2000736 50 0.382
cell matrix adhesion GO:0007160 68 0.382
negative regulation of dendrite development GO:2000171 9 0.381
cellular component assembly involved in morphogenesis GO:0010927 139 0.380
glial cell apoptotic process GO:0034349 3 0.378
neurotrophin trk receptor signaling pathway GO:0048011 8 0.373
blastocyst development GO:0001824 80 0.373
actin filament bundle assembly GO:0051017 40 0.368
bmp signaling pathway GO:0030509 93 0.365
regulation of lyase activity GO:0051339 13 0.364
Yeast
response to peptide hormone GO:0043434 127 0.362
molting cycle GO:0042303 90 0.359
developmental programmed cell death GO:0010623 41 0.357
Fly
regulation of stress fiber assembly GO:0051492 15 0.356
embryonic skeletal system development GO:0048706 120 0.356
Zebrafish
establishment or maintenance of bipolar cell polarity GO:0061245 21 0.355
Fly
male gamete generation GO:0048232 285 0.354
actomyosin structure organization GO:0031032 56 0.352
regulation of cardioblast differentiation GO:0051890 3 0.349
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 57 0.348
cyclic purine nucleotide metabolic process GO:0052652 43 0.347
Yeast
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.346
microtubule based process GO:0007017 236 0.344
negative regulation of cell size GO:0045792 3 0.341
regulation of neurotransmitter levels GO:0001505 87 0.340
negative regulation of transferase activity GO:0051348 85 0.339
dna replication GO:0006260 52 0.337
organic cyclic compound catabolic process GO:1901361 295 0.337
regulation of leukocyte differentiation GO:1902105 159 0.336
t cell differentiation GO:0030217 174 0.334
response to drug GO:0042493 75 0.334
attachment of spindle microtubules to kinetochore GO:0008608 4 0.332
regulation of synaptic vesicle transport GO:1902803 13 0.330
antral ovarian follicle growth GO:0001547 5 0.329
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.329
monocarboxylic acid metabolic process GO:0032787 191 0.328
oligodendrocyte differentiation GO:0048709 53 0.327
regulation of cell growth GO:0001558 91 0.327
erbb signaling pathway GO:0038127 32 0.326
Worm
regulation of translation GO:0006417 71 0.326
regulation of rho protein signal transduction GO:0035023 71 0.324
regulation of cell cycle g1 s phase transition GO:1902806 35 0.322
erk1 and erk2 cascade GO:0070371 77 0.322

Kras disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 1.000
Human
endocrine gland cancer DOID:170 0 1.000
Human
cancer DOID:162 0 1.000
Human
organ system cancer DOID:0050686 0 1.000
Human
noonan syndrome DOID:3490 0 0.999
Human
large intestine cancer DOID:5672 0 0.984
colon cancer DOID:219 0 0.984
gastrointestinal system cancer DOID:3119 0 0.984
Human
intestinal cancer DOID:10155 0 0.984
colorectal cancer DOID:9256 0 0.984
thyroid cancer DOID:1781 0 0.975
respiratory system cancer DOID:0050615 0 0.755
Human
lung cancer DOID:1324 0 0.755
Human
reproductive organ cancer DOID:193 0 0.524
immune system cancer DOID:0060083 0 0.497
hematologic cancer DOID:2531 0 0.497
colon carcinoma DOID:1520 0 0.471
nervous system cancer DOID:3093 0 0.368
central nervous system cancer DOID:3620 0 0.368
liver carcinoma DOID:686 0 0.362
liver cancer DOID:3571 0 0.362