Mus musculus

0 known processes

Lair1

leukocyte-associated Ig-like receptor 1

(Aliases: 5133400O11Rik,D7Bwg0421e,mLair-1,Lair-1,BB115266)

Lair1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of mast cell activation GO:0033003 21 0.930
cell surface pattern recognition receptor signaling pathway GO:0002752 2 0.872
response to molecule of fungal origin GO:0002238 4 0.740
purinergic nucleotide receptor signaling pathway GO:0035590 3 0.710
negative regulation of immune system process GO:0002683 209 0.631
detection of fungus GO:0016046 2 0.613
t cell activation GO:0042110 289 0.590
defense response to other organism GO:0098542 197 0.571
g protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 1 0.534
regulation of cell activation GO:0050865 289 0.520
immune effector process GO:0002252 321 0.517
cytokine production GO:0001816 319 0.508
detection of external biotic stimulus GO:0098581 9 0.505
myeloid leukocyte activation GO:0002274 83 0.501
regulation of natural killer cell activation GO:0032814 22 0.493
toll like receptor 9 signaling pathway GO:0034162 6 0.488
leukocyte mediated immunity GO:0002443 174 0.469
cation transport GO:0006812 399 0.457
defense response to bacterium GO:0042742 119 0.445
cellular response to peptidoglycan GO:0071224 4 0.444
detection of biotic stimulus GO:0009595 10 0.430
positive regulation of immune effector process GO:0002699 107 0.421
leukocyte proliferation GO:0070661 172 0.407
toll like receptor signaling pathway GO:0002224 38 0.406
regulation of lymphocyte activation GO:0051249 240 0.378
reactive oxygen species metabolic process GO:0072593 84 0.373
innate immune response GO:0045087 157 0.369
immune response regulating signaling pathway GO:0002764 125 0.363
regulation of leukocyte mediated immunity GO:0002703 104 0.356
positive regulation of protein transport GO:0051222 93 0.355
immune response regulating cell surface receptor signaling pathway GO:0002768 80 0.353
serotonin secretion involved in inflammatory response GO:0002442 4 0.334
regulation of protein transport GO:0051223 163 0.331
activation of innate immune response GO:0002218 56 0.328
regulation of innate immune response GO:0045088 91 0.318
regulation of toll like receptor 9 signaling pathway GO:0034163 3 0.308
positive regulation of cytokine secretion GO:0050715 41 0.302
cellular response to biotic stimulus GO:0071216 92 0.300
protein secretion GO:0009306 111 0.296
regulation of protein secretion GO:0050708 82 0.287
detection of other organism GO:0098543 8 0.284
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.278
myeloid leukocyte mediated immunity GO:0002444 42 0.278
cytoplasmic transport GO:0016482 234 0.273
regulation of antigen receptor mediated signaling pathway GO:0050854 29 0.269
negative regulation of cell activation GO:0050866 111 0.262
positive regulation of leukocyte mediated immunity GO:0002705 70 0.259
regulation of cytokine production GO:0001817 266 0.259
activation of immune response GO:0002253 138 0.256
leukocyte degranulation GO:0043299 27 0.255
immune response activating signal transduction GO:0002757 116 0.253
regulation of intracellular transport GO:0032386 159 0.250
membrane organization GO:0061024 245 0.248
regulation of leukocyte mediated cytotoxicity GO:0001910 38 0.244
immune response activating cell surface receptor signaling pathway GO:0002429 72 0.243
reactive oxygen species biosynthetic process GO:1903409 8 0.239
serotonin secretion GO:0001820 8 0.235
positive regulation of secretion by cell GO:1903532 114 0.230
innate immune response activating signal transduction GO:0002758 50 0.229
positive regulation of defense response GO:0031349 124 0.229
regulation of reactive oxygen species biosynthetic process GO:1903426 2 0.218
regulation of protein localization GO:0032880 231 0.218
regulation of establishment of protein localization GO:0070201 181 0.216
cellular response to molecule of fungal origin GO:0071226 2 0.215
regulation of secretion GO:0051046 274 0.209
regulation of exocytosis GO:0017157 61 0.202
regulation of cellular amino acid metabolic process GO:0006521 5 0.201
inflammatory response GO:0006954 244 0.197
regulation of secretion by cell GO:1903530 249 0.197
positive regulation of intracellular transport GO:0032388 70 0.193
leukocyte activation involved in immune response GO:0002366 126 0.193
cellular amine metabolic process GO:0044106 44 0.190
regulation of interleukin 6 production GO:0032675 55 0.188
natural killer cell activation GO:0030101 44 0.187
regulation of lymphocyte proliferation GO:0050670 117 0.186
mapk cascade GO:0000165 281 0.182
cytokine metabolic process GO:0042107 71 0.182
positive regulation of interleukin 18 production GO:0032741 2 0.178
stimulatory c type lectin receptor signaling pathway GO:0002223 2 0.177
nitrogen compound transport GO:0071705 271 0.176
reactive nitrogen species metabolic process GO:2001057 0 0.165
single organismal cell cell adhesion GO:0016337 131 0.161
regulation of vesicle mediated transport GO:0060627 139 0.159
detection of molecule of bacterial origin GO:0032490 2 0.159
i kappab kinase nf kappab signaling GO:0007249 85 0.159
myeloid cell differentiation GO:0030099 233 0.159
regulation of cell migration GO:0030334 219 0.158
negative regulation of serotonin secretion GO:0014063 2 0.158
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 50 0.156
positive regulation of cytokine production GO:0001819 174 0.154
calcium mediated signaling GO:0019722 46 0.154
regulation of defense response GO:0031347 233 0.152
tumor necrosis factor superfamily cytokine production GO:0071706 51 0.152
regulation of leukocyte proliferation GO:0070663 121 0.148
g protein coupled receptor signaling pathway GO:0007186 243 0.147
positive regulation of secretion GO:0051047 130 0.143
response to molecule of bacterial origin GO:0002237 143 0.142
positive regulation of cellular amine metabolic process GO:0033240 5 0.139
tumor necrosis factor production GO:0032640 50 0.139
regulation of tumor necrosis factor production GO:0032680 49 0.139
leukocyte mediated cytotoxicity GO:0001909 62 0.138
lymphocyte proliferation GO:0046651 164 0.135
second messenger mediated signaling GO:0019932 73 0.134
positive regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045425 2 0.132
toll like receptor 7 signaling pathway GO:0034154 4 0.132
pattern recognition receptor signaling pathway GO:0002221 47 0.132
regulation of ion transport GO:0043269 215 0.131
regulation of interferon gamma production GO:0032649 57 0.130
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 87 0.130
detection of stimulus GO:0051606 84 0.129
positive regulation of protein secretion GO:0050714 52 0.129
regulation of t cell activation GO:0050863 170 0.128
cellular amino acid metabolic process GO:0006520 103 0.127
mast cell activation GO:0045576 27 0.126
amine metabolic process GO:0009308 45 0.126
serotonin production involved in inflammatory response GO:0002351 4 0.126
detection of yeast GO:0001879 2 0.125
cytokine secretion GO:0050663 72 0.124
innate immune response activating cell surface receptor signaling pathway GO:0002220 4 0.124
positive regulation of reactive oxygen species metabolic process GO:2000379 11 0.124
regulation of kinase activity GO:0043549 249 0.122
negative t cell selection GO:0043383 13 0.120
cell activation involved in immune response GO:0002263 126 0.120
mast cell degranulation GO:0043303 19 0.120
cellular response to lipopolysaccharide GO:0071222 77 0.119
negative regulation of mast cell degranulation GO:0043305 4 0.117
positive regulation of calcium mediated signaling GO:0050850 15 0.111
lysosome localization GO:0032418 20 0.111
myeloid cell activation involved in immune response GO:0002275 34 0.110
positive regulation of leukocyte mediated cytotoxicity GO:0001912 31 0.110
regulation of protein kinase activity GO:0045859 232 0.110
regulation of cytokine biosynthetic process GO:0042035 59 0.110
cellular response to molecule of bacterial origin GO:0071219 83 0.107
mast cell mediated immunity GO:0002448 20 0.107
response to lipopolysaccharide GO:0032496 128 0.104
positive regulation of protein modification process GO:0031401 299 0.101
t cell proliferation GO:0042098 120 0.101
platelet activation GO:0030168 40 0.097
negative regulation of immune effector process GO:0002698 55 0.097
positive regulation by symbiont of host defense response GO:0052509 1 0.097
regulation of cytokine secretion GO:0050707 61 0.096
regulation of cellular ketone metabolic process GO:0010565 66 0.096
regulation of phagocytosis GO:0050764 33 0.094
cellular homeostasis GO:0019725 240 0.093
positive regulation of innate immune response GO:0045089 80 0.093
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.091
blood coagulation GO:0007596 76 0.088
production of molecular mediator involved in inflammatory response GO:0002532 21 0.087
single organism cell adhesion GO:0098602 156 0.086
leukocyte differentiation GO:0002521 342 0.086
regulation of cell motility GO:2000145 236 0.085
positive regulation of toll like receptor 9 signaling pathway GO:0034165 2 0.085
cellular ion homeostasis GO:0006873 165 0.084
negative regulation of leukocyte mediated immunity GO:0002704 29 0.084
negative regulation of phosphorylation GO:0042326 166 0.084
regulation of protein serine threonine kinase activity GO:0071900 157 0.083
regulation of t cell proliferation GO:0042129 92 0.083
positive regulation of lymphocyte mediated immunity GO:0002708 62 0.082
regulation of mast cell degranulation GO:0043304 16 0.082
serotonin transport GO:0006837 11 0.081
regulation of multi organism process GO:0043900 111 0.081
intracellular protein transport GO:0006886 204 0.080
detection of bacterium GO:0016045 7 0.080
regulation of transferase activity GO:0051338 263 0.079
positive regulation of endocytosis GO:0045807 42 0.076
phagocytosis GO:0006909 66 0.075
immunoglobulin transcytosis in epithelial cells GO:0002414 2 0.074
intestinal epithelial structure maintenance GO:0060729 4 0.074
exocytosis GO:0006887 121 0.073
protein targeting GO:0006605 143 0.072
interleukin 18 production GO:0032621 4 0.071
regulation of cellular amine metabolic process GO:0033238 20 0.071
t cell receptor signaling pathway GO:0050852 46 0.070
positive regulation of interferon alpha biosynthetic process GO:0045356 1 0.070
positive regulation of mast cell degranulation GO:0043306 10 0.070
negative regulation of phosphorus metabolic process GO:0010563 184 0.070
endocytosis GO:0006897 168 0.069
positive regulation by symbiont of defense related host nitric oxide production GO:0052347 1 0.069
unsaturated fatty acid metabolic process GO:0033559 31 0.068
regulation of inflammatory response GO:0050727 147 0.068
positive regulation of lymphocyte proliferation GO:0050671 70 0.067
negative regulation of phosphate metabolic process GO:0045936 184 0.067
positive regulation of transferase activity GO:0051347 167 0.066
mast cell activation involved in immune response GO:0002279 20 0.066
negative regulation of protein metabolic process GO:0051248 282 0.066
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 145 0.065
multicellular organismal homeostasis GO:0048871 164 0.065
regulation of body fluid levels GO:0050878 162 0.065
response to host GO:0075136 3 0.065
organic hydroxy compound transport GO:0015850 93 0.065
regulation of serotonin secretion GO:0014062 3 0.064
regulation of b cell proliferation GO:0030888 39 0.063
protein localization to organelle GO:0033365 185 0.063
establishment or maintenance of cytoskeleton polarity GO:0030952 2 0.062
tumor necrosis factor biosynthetic process GO:0042533 10 0.061
coagulation GO:0050817 78 0.061
cellular response to drug GO:0035690 15 0.061
positive regulation of hemostasis GO:1900048 10 0.060
sequestering of metal ion GO:0051238 19 0.060
negative regulation of cellular component organization GO:0051129 194 0.060
peptidyl amino acid modification GO:0018193 336 0.060
cell chemotaxis GO:0060326 81 0.059
maintenance of location GO:0051235 89 0.059
induction by symbiont of host immune response GO:0052559 1 0.059
regulation of natural killer cell mediated immunity GO:0002715 19 0.058
positive regulation of natural killer cell mediated immunity GO:0002717 16 0.058
divalent inorganic cation transport GO:0072511 178 0.057
antigen receptor mediated signaling pathway GO:0050851 64 0.057
leukotriene metabolic process GO:0006691 7 0.057
regulation of regulated secretory pathway GO:1903305 20 0.057
negative regulation of cellular protein metabolic process GO:0032269 247 0.057
blood vessel morphogenesis GO:0048514 285 0.056
toxin catabolic process GO:0009407 1 0.055
positive regulation of regulated secretory pathway GO:1903307 10 0.055
cellular metal ion homeostasis GO:0006875 151 0.055
cellular ketone metabolic process GO:0042180 84 0.054
regulation of chemokine production GO:0032642 30 0.054
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 31 0.054
protein import into nucleus GO:0006606 95 0.054
cellular response to lipid GO:0071396 145 0.053
cellular lipid metabolic process GO:0044255 323 0.052
positive regulation of interferon gamma production GO:0032729 39 0.052
regulation of erk1 and erk2 cascade GO:0070372 71 0.052
regulation of calcium mediated signaling GO:0050848 19 0.052
cell adhesion GO:0007155 329 0.052
regulation of cellular response to stress GO:0080135 159 0.051
inorganic cation transmembrane transport GO:0098662 207 0.051
positive regulation of kinase activity GO:0033674 155 0.051
activation of mapk activity GO:0000187 59 0.051
macrophage activation GO:0042116 27 0.051
negative regulation of intracellular signal transduction GO:1902532 167 0.049
regulation of reactive oxygen species metabolic process GO:2000377 40 0.049
positive regulation of cell killing GO:0031343 33 0.049
induction by organism of defense response of other organism involved in symbiotic interaction GO:0052251 1 0.049
positive regulation of tumor necrosis factor production GO:0032760 30 0.049
unsaturated fatty acid biosynthetic process GO:0006636 15 0.049
regulation of granulocyte macrophage colony stimulating factor production GO:0032645 3 0.049
thymic t cell selection GO:0045061 22 0.048
cellular response to organonitrogen compound GO:0071417 145 0.048
leukocyte migration GO:0050900 124 0.048
nitric oxide biosynthetic process GO:0006809 25 0.048
granulocyte macrophage colony stimulating factor production GO:0032604 3 0.048
regulation of cell killing GO:0031341 40 0.048
purinergic receptor signaling pathway GO:0035587 7 0.048
positive regulation of coagulation GO:0050820 13 0.047
positive regulation of phagocytosis GO:0050766 26 0.047
tissue homeostasis GO:0001894 115 0.047
ras protein signal transduction GO:0007265 77 0.047
detection of peptidoglycan GO:0032499 1 0.046
metal ion homeostasis GO:0055065 189 0.046
organelle localization GO:0051640 179 0.046
cellular chemical homeostasis GO:0055082 215 0.046
regulation of granulocyte macrophage colony stimulating factor biosynthetic process GO:0045423 2 0.045
protein import GO:0017038 101 0.045
protein ubiquitination GO:0016567 171 0.045
regulation of tumor necrosis factor biosynthetic process GO:0042534 10 0.045
negative regulation of mapk cascade GO:0043409 65 0.045
production of molecular mediator of immune response GO:0002440 103 0.044
cytokine biosynthetic process GO:0042089 68 0.044
regulation of mapk cascade GO:0043408 248 0.044
response to defense related nitric oxide production by other organism involved in symbiotic interaction GO:0052551 2 0.044
nitric oxide metabolic process GO:0046209 25 0.044
positive regulation of leukocyte degranulation GO:0043302 10 0.043
natural killer cell mediated immunity GO:0002228 29 0.043
response to host immune response GO:0052572 3 0.043
small molecule biosynthetic process GO:0044283 132 0.043
type i interferon production GO:0032606 29 0.043
sequestering of calcium ion GO:0051208 18 0.043
positive regulation of lymphocyte activation GO:0051251 140 0.043
interferon beta biosynthetic process GO:0045350 4 0.042
positive regulation of t cell extravasation GO:2000409 2 0.042
nuclear import GO:0051170 95 0.042
induction by organism of immune response of other organism involved in symbiotic interaction GO:0052558 1 0.042
natural killer cell mediated cytotoxicity GO:0042267 29 0.042
regulation of t cell costimulation GO:2000523 2 0.042
protein modification by small protein conjugation or removal GO:0070647 207 0.041
chemotaxis GO:0006935 247 0.041
divalent metal ion transport GO:0070838 172 0.041
cation transmembrane transport GO:0098655 266 0.041
positive regulation of interferon alpha production GO:0032727 4 0.041
regulation of jnk cascade GO:0046328 62 0.041
lipid biosynthetic process GO:0008610 179 0.041
cell recognition GO:0008037 83 0.040
regulation of map kinase activity GO:0043405 120 0.040
wound healing GO:0042060 157 0.040
regulated secretory pathway GO:0045055 32 0.040
alpha beta t cell activation GO:0046631 91 0.039
positive regulation of homeostatic process GO:0032846 64 0.039
erk1 and erk2 cascade GO:0070371 77 0.039
t cell differentiation in thymus GO:0033077 77 0.039
anatomical structure homeostasis GO:0060249 145 0.039
stress activated protein kinase signaling cascade GO:0031098 81 0.038
regulation of response to wounding GO:1903034 189 0.038
microtubule based process GO:0007017 236 0.038
regulation of myeloid leukocyte mediated immunity GO:0002886 25 0.037
positive regulation of cell activation GO:0050867 158 0.037
nucleocytoplasmic transport GO:0006913 139 0.037
positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8 0.036
adaptive immune response GO:0002250 155 0.036
regulation of nitric oxide biosynthetic process GO:0045428 18 0.036
interferon gamma production GO:0032609 67 0.036
regulation of homeostatic process GO:0032844 182 0.036
cellular divalent inorganic cation homeostasis GO:0072503 127 0.036
cellular response to cytokine stimulus GO:0071345 189 0.036
regulation of organelle organization GO:0033043 289 0.035
embryonic placenta development GO:0001892 98 0.035
positive regulation of response to wounding GO:1903036 66 0.035
regulation of mast cell activation involved in immune response GO:0033006 17 0.035
regulation of endocytosis GO:0030100 69 0.035
lymphocyte mediated immunity GO:0002449 139 0.035
transmembrane transport GO:0055085 412 0.035
regulation of ion homeostasis GO:2000021 64 0.035
regulation of lymphocyte mediated immunity GO:0002706 84 0.034
response to defense related host nitric oxide production GO:0052565 2 0.034
hemostasis GO:0007599 78 0.034
protein localization to nucleus GO:0034504 121 0.034
positive regulation of mast cell activation GO:0033005 12 0.034
regulation of coagulation GO:0050818 31 0.033
ossification GO:0001503 216 0.033
neutrophil chemotaxis GO:0030593 36 0.033
nuclear transport GO:0051169 139 0.033
neutrophil mediated immunity GO:0002446 19 0.032
regulation of vesicle fusion GO:0031338 6 0.032
positive regulation of protein kinase activity GO:0045860 144 0.032
positive regulation of erk1 and erk2 cascade GO:0070374 47 0.032
positive regulation of leukocyte proliferation GO:0070665 73 0.032
positive regulation of natural killer cell mediated cytotoxicity GO:0045954 16 0.032
small gtpase mediated signal transduction GO:0007264 97 0.032
negative regulation of lymphocyte proliferation GO:0050672 45 0.032
regulation of adaptive immune response GO:0002819 90 0.032
monocarboxylic acid biosynthetic process GO:0072330 61 0.032
positive regulation of alpha beta t cell activation GO:0046635 39 0.032
regulation of interleukin 18 production GO:0032661 3 0.032
superoxide metabolic process GO:0006801 27 0.031
t cell differentiation GO:0030217 174 0.031
defense response to gram positive bacterium GO:0050830 50 0.031
negative regulation of phagocytosis GO:0050765 4 0.031
positive regulation of cell migration GO:0030335 109 0.031
sensory perception GO:0007600 245 0.031
placenta development GO:0001890 140 0.031
kidney development GO:0001822 213 0.031
interleukin 6 production GO:0032635 58 0.031
protein modification by small protein conjugation GO:0032446 187 0.030
response to bacterial lipoprotein GO:0032493 4 0.030
dna metabolic process GO:0006259 303 0.030
nucleobase containing small molecule metabolic process GO:0055086 352 0.030
inorganic ion transmembrane transport GO:0098660 234 0.030
negative regulation of ripoptosome assembly involved in necroptotic process GO:1902443 3 0.030
positive regulation of cytokine biosynthetic process GO:0042108 40 0.029
cation homeostasis GO:0055080 212 0.029
ameboidal type cell migration GO:0001667 128 0.029
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 5 0.029
oxidation reduction process GO:0055114 342 0.029
positive regulation of stress activated mapk cascade GO:0032874 48 0.028
negative regulation of regulated secretory pathway GO:1903306 7 0.028
regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070428 3 0.028
negative regulation of protein modification process GO:0031400 163 0.028
positive regulation of granulocyte macrophage colony stimulating factor production GO:0032725 3 0.028
regulation of leukocyte differentiation GO:1902105 159 0.028
purine ribonucleoside triphosphate metabolic process GO:0009205 220 0.028
cytosolic calcium ion homeostasis GO:0051480 70 0.028
response to host defenses GO:0052200 3 0.028
regulation of b cell activation GO:0050864 81 0.028
homeostasis of number of cells GO:0048872 210 0.028
positive regulation of myeloid leukocyte mediated immunity GO:0002888 14 0.028
organic cyclic compound catabolic process GO:1901361 295 0.027
nucleoside catabolic process GO:0009164 206 0.027
modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052552 1 0.027
erythrocyte differentiation GO:0030218 88 0.027
ribonucleoside metabolic process GO:0009119 245 0.027
ribose phosphate metabolic process GO:0019693 291 0.027
peptidyl tyrosine modification GO:0018212 145 0.027
positive regulation of interferon beta biosynthetic process GO:0045359 3 0.027
modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052255 1 0.027
lymphocyte differentiation GO:0030098 242 0.026
detection of lipopolysaccharide GO:0032497 1 0.026
positive regulation by organism of defense related nitric oxide production in other organism involved in symbiotic interaction GO:0052345 1 0.026
jnk cascade GO:0007254 72 0.026
negative regulation of interleukin 23 production GO:0032707 1 0.026
regulation of hemostasis GO:1900046 28 0.026
germ cell development GO:0007281 185 0.026
neutrophil degranulation GO:0043312 6 0.026
b cell activation involved in immune response GO:0002312 50 0.026
positive regulation of nervous system development GO:0051962 221 0.026
b cell activation GO:0042113 161 0.026
positive regulation of nitric oxide biosynthetic process GO:0045429 14 0.025
regulation of osteoclast differentiation GO:0045670 36 0.025
response to growth factor GO:0070848 198 0.025
regulation of leukocyte degranulation GO:0043300 20 0.025
carboxylic acid biosynthetic process GO:0046394 86 0.025
positive regulation of cell motility GO:2000147 116 0.025
regulation of metal ion transport GO:0010959 106 0.025
renal system development GO:0072001 225 0.025
peptidyl serine phosphorylation GO:0018105 74 0.025
monocarboxylic acid metabolic process GO:0032787 191 0.025
regulation of natural killer cell mediated cytotoxicity GO:0042269 19 0.024
cd8 positive alpha beta t cell extravasation GO:0035697 3 0.024
response to defenses of other organism involved in symbiotic interaction GO:0052173 3 0.024
gtp catabolic process GO:0006184 143 0.024
cellular calcium ion homeostasis GO:0006874 119 0.024
regulation of blood coagulation GO:0030193 28 0.024
positive regulation of nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070434 2 0.024
phagocytosis recognition GO:0006910 12 0.024
regulation of t cell receptor signaling pathway GO:0050856 21 0.024
negative regulation of hypersensitivity GO:0002884 3 0.024
positive regulation of t cell activation GO:0050870 101 0.024
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 61 0.024
negative regulation of erk1 and erk2 cascade GO:0070373 21 0.024
regulation of t cell extravasation GO:2000407 3 0.024
monoamine transport GO:0015844 33 0.024
positive regulation of jnk cascade GO:0046330 46 0.024
negative regulation of adaptive immune response GO:0002820 25 0.024
regulation of nucleotide binding oligomerization domain containing signaling pathway GO:0070424 3 0.023
t cell mediated immunity GO:0002456 50 0.023
negative regulation of lymphocyte activation GO:0051250 91 0.023
negative regulation of synapse assembly GO:0051964 3 0.023
positive regulation of mhc class ii biosynthetic process GO:0045348 4 0.023
nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070427 5 0.023
apoptotic signaling pathway GO:0097190 306 0.023
spermatogenesis GO:0007283 284 0.023
regulation of alpha beta t cell activation GO:0046634 53 0.023
regulation of calcium ion transport GO:0051924 69 0.023
neural precursor cell proliferation GO:0061351 121 0.023
regulation of interferon beta biosynthetic process GO:0045357 4 0.023
fatty acid metabolic process GO:0006631 121 0.023
phosphatidylinositol mediated signaling GO:0048015 41 0.023
positive regulation of t cell costimulation GO:2000525 2 0.022
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 54 0.022
regulation of monocyte chemotaxis GO:0090025 3 0.022
signal transduction in absence of ligand GO:0038034 55 0.022
microglial cell activation GO:0001774 3 0.022
regulation of peptidyl tyrosine phosphorylation GO:0050730 93 0.022
calcium ion transport GO:0006816 159 0.022
positive regulation of lymphocyte differentiation GO:0045621 61 0.022
positive regulation of chemokine secretion GO:0090197 4 0.022
cell killing GO:0001906 67 0.022
response to immune response of other organism involved in symbiotic interaction GO:0052564 3 0.022
organic acid biosynthetic process GO:0016053 86 0.022
divalent inorganic cation homeostasis GO:0072507 138 0.022
cytokine production involved in immune response GO:0002367 34 0.022
stress activated mapk cascade GO:0051403 80 0.022
regulation of platelet activation GO:0010543 17 0.022
positive regulation of cd8 positive alpha beta t cell extravasation GO:2000451 2 0.021
purine containing compound metabolic process GO:0072521 311 0.021
cellular response to lipoteichoic acid GO:0071223 6 0.021
regulation of ossification GO:0030278 112 0.021
positive regulation of exocytosis GO:0045921 20 0.021
regulation of synaptic growth at neuromuscular junction GO:0008582 4 0.021
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 6 0.021
chemokine production GO:0032602 34 0.021
fatty acid derivative metabolic process GO:1901568 33 0.021
negative regulation of cytokine production GO:0001818 84 0.021
eosinophil activation GO:0043307 1 0.021
positive regulation of leukocyte differentiation GO:1902107 86 0.021
negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002823 23 0.021
interferon alpha biosynthetic process GO:0045349 1 0.021
positive regulation of nucleotide binding oligomerization domain containing 1 signaling pathway GO:0070430 1 0.021
positive regulation of mast cell activation involved in immune response GO:0033008 10 0.021
regulation of hormone levels GO:0010817 211 0.021
negative thymic t cell selection GO:0045060 12 0.021
negative regulation of t cell activation GO:0050868 65 0.020
muscle cell differentiation GO:0042692 261 0.020
regulation of intracellular protein transport GO:0033157 82 0.020
regulation of membrane potential GO:0042391 192 0.020
regulation of myeloid leukocyte differentiation GO:0002761 58 0.020
intracellular mrna localization GO:0008298 4 0.020
regulation of cell cycle process GO:0010564 160 0.020
leukocyte chemotaxis GO:0030595 69 0.020
positive regulation of monocyte chemotaxis GO:0090026 2 0.020
calcium ion homeostasis GO:0055074 127 0.020
negative regulation of homeostatic process GO:0032845 71 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 199 0.020
negative regulation of transferase activity GO:0051348 85 0.020
positive regulation of interleukin 6 production GO:0032755 37 0.020
negative regulation of interferon gamma production GO:0032689 18 0.020
lateral inhibition GO:0046331 1 0.020
regulation of antimicrobial peptide biosynthetic process GO:0002805 1 0.020
negative regulation of defense response GO:0031348 77 0.020
monocyte extravasation GO:0035696 2 0.020
multicellular organismal signaling GO:0035637 91 0.020
positive regulation of monocyte extravasation GO:2000439 1 0.019
establishment of protein localization to organelle GO:0072594 118 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 247 0.019

Lair1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in mouse and predicted with the mouse functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.186
musculoskeletal system disease DOID:17 0 0.186
connective tissue disease DOID:65 0 0.186
disease of metabolism DOID:0014667 0 0.057
bone disease DOID:0080001 0 0.038
bone inflammation disease DOID:3342 0 0.033
arthritis DOID:848 0 0.033
lupus erythematosus DOID:8857 0 0.026
immune system disease DOID:2914 0 0.026
hypersensitivity reaction disease DOID:0060056 0 0.026
hypersensitivity reaction type ii disease DOID:417 0 0.026
acquired metabolic disease DOID:0060158 0 0.021
systemic lupus erythematosus DOID:9074 0 0.021
sensory system disease DOID:0050155 0 0.021
nervous system disease DOID:863 0 0.021
rheumatoid arthritis DOID:7148 0 0.020